Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort / S. RAZA in Journal of Autism and Developmental Disorders, 49-5 (May 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2210-2218 Titre : Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort Type de document : Texte imprimé et/ou numérique Auteurs : S. RAZA, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Lori-Ann R. SACREY, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; K. REID, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur Article en page(s) : p.2210-2218 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Behavioral signs  Classification accuracy  Early screening  Infant siblings Index. décimale : PER Périodiques Résumé : This study examined the potential of the short form of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) to identify autism spectrum disorder (ASD) in a high-risk sibling cohort. High-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers were assessed prospectively at 18 and 24 months of age using the Q-CHAT-10 and underwent blind diagnostic assessment for ASD at 36 months of age. The results indicated that at 18 and 24 months, total score differentiated between HR toddlers subsequently diagnosed with ASD from other HR and LR toddlers. The sensitivity at both time points was acceptable; however, the specificity was below the level recommended for clinical application. En ligne : http://dx.doi.org/10.1007/s10803-019-03897-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394 [article] Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort [Texte imprimé et/ou numérique] / S. RAZA, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Lori-Ann R. SACREY, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; K. REID, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur . - p.2210-2218. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2210-2218 Mots-clés : Autism  Autism spectrum disorder  Behavioral signs  Classification accuracy  Early screening  Infant siblings Index. décimale : PER Périodiques Résumé : This study examined the potential of the short form of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) to identify autism spectrum disorder (ASD) in a high-risk sibling cohort. High-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers were assessed prospectively at 18 and 24 months of age using the Q-CHAT-10 and underwent blind diagnostic assessment for ASD at 36 months of age. The results indicated that at 18 and 24 months, total score differentiated between HR toddlers subsequently diagnosed with ASD from other HR and LR toddlers. The sensitivity at both time points was acceptable; however, the specificity was below the level recommended for clinical application. En ligne : http://dx.doi.org/10.1007/s10803-019-03897-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394

Developmental trajectories of adaptive behavior in autism spectrum disorder: a high-risk sibling cohort / Lori-Ann R. SACREY in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.697-706 Titre : Developmental trajectories of adaptive behavior in autism spectrum disorder: a high-risk sibling cohort Type de document : Texte imprimé et/ou numérique Auteurs : Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; S. RAZA, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur Article en page(s) : p.697-706 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  adaptive behaviour  development  high risk studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) often experience impairments in adaptive behavior. METHODS: Developmental trajectories of adaptive behavior in ASD were examined in children from high-risk (siblings of children diagnosed with ASD, n = 403) and low-risk (no family history of ASD, n = 163) families. Children were assessed prospectively at 12, 18, 24, and 36 months of age using the Vineland Adaptive Behavior Scales and underwent a blind independent diagnostic assessment for ASD at 36 months of age. RESULTS: The semi-parametric group-based modeling approach using standard scores on the Adaptive Behavior Composite revealed three distinct developmental trajectories: (a) Group 1 (21.2% of sample) showed average performance at 12 months and a declining trajectory; (b) Group 2 (52.8% of the sample) showed average performance at 12 months with a slightly declining trajectory; and (c) Group 3 (26.0% of the sample) showed a higher level of adaptive behavior at 12 months and a stable trajectory. The Mullen Scales of Early Learning Early Learning Composite and the Autism Observation Scale for Infants total score at 6 and 12 months predicted trajectory membership. CONCLUSIONS: The results emphasize heterogeneous development associated with ASD and the need for interventions tailored to individual presentations. En ligne : http://dx.doi.org/10.1111/jcpp.12985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Developmental trajectories of adaptive behavior in autism spectrum disorder: a high-risk sibling cohort [Texte imprimé et/ou numérique] / Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; S. RAZA, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur . - p.697-706. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.697-706 Mots-clés : Autism spectrum disorders  adaptive behaviour  development  high risk studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) often experience impairments in adaptive behavior. METHODS: Developmental trajectories of adaptive behavior in ASD were examined in children from high-risk (siblings of children diagnosed with ASD, n = 403) and low-risk (no family history of ASD, n = 163) families. Children were assessed prospectively at 12, 18, 24, and 36 months of age using the Vineland Adaptive Behavior Scales and underwent a blind independent diagnostic assessment for ASD at 36 months of age. RESULTS: The semi-parametric group-based modeling approach using standard scores on the Adaptive Behavior Composite revealed three distinct developmental trajectories: (a) Group 1 (21.2% of sample) showed average performance at 12 months and a declining trajectory; (b) Group 2 (52.8% of the sample) showed average performance at 12 months with a slightly declining trajectory; and (c) Group 3 (26.0% of the sample) showed a higher level of adaptive behavior at 12 months and a stable trajectory. The Mullen Scales of Early Learning Early Learning Composite and the Autism Observation Scale for Infants total score at 6 and 12 months predicted trajectory membership. CONCLUSIONS: The results emphasize heterogeneous development associated with ASD and the need for interventions tailored to individual presentations. En ligne : http://dx.doi.org/10.1111/jcpp.12985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders / M. T. SIU in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3610-3623 Titre : DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : M. T. SIU, Auteur ; S. J. GOODMAN, Auteur ; I. YELLAN, Auteur ; D. T. BUTCHER, Auteur ; M. JANGJOO, Auteur ; D. GRAFODATSKAYA, Auteur ; R. RAJENDRAM, Auteur ; Y. LOU, Auteur ; R. ZHANG, Auteur ; C. ZHAO, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; P. SZATMARI, Auteur ; Stephen SCHERER, Auteur ; W. ROBERTS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. WEKSBERG, Auteur Article en page(s) : p.3610-3623 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics  Autism Spectrum Disorder/genetics  DNA Methylation  Female  Humans  Male  Obsessive-Compulsive Disorder  Oxytocin/metabolism  Receptors, Oxytocin/genetics  Adhd  Asd  Ocd  Oxtr Index. décimale : PER Périodiques Résumé : Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04792-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / M. T. SIU, Auteur ; S. J. GOODMAN, Auteur ; I. YELLAN, Auteur ; D. T. BUTCHER, Auteur ; M. JANGJOO, Auteur ; D. GRAFODATSKAYA, Auteur ; R. RAJENDRAM, Auteur ; Y. LOU, Auteur ; R. ZHANG, Auteur ; C. ZHAO, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; P. SZATMARI, Auteur ; Stephen SCHERER, Auteur ; W. ROBERTS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. WEKSBERG, Auteur . - p.3610-3623. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3610-3623 Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics  Autism Spectrum Disorder/genetics  DNA Methylation  Female  Humans  Male  Obsessive-Compulsive Disorder  Oxytocin/metabolism  Receptors, Oxytocin/genetics  Adhd  Asd  Ocd  Oxtr Index. décimale : PER Périodiques Résumé : Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04792-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder / Jessica BRIAN in Research in Autism Spectrum Disorders, 8-11 (November 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1557-1566 Titre : Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRIAN, Auteur ; C. RONCADIN, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; I. DRMIC, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.1557-1566 Langues : Anglais (eng) Mots-clés : High-risk siblings  Cognitive development  Infants  Toddlers  Developmental trajectories  ASD Index. décimale : PER Périodiques Résumé : This paper examined early developmental trajectories in a large, longitudinal sample at high-risk for ASD (‘HR’) and low-risk (‘LR’) controls, and the association of trajectories with 3-year diagnosis. Developmental assessments were conducted at 6, 12, 24 months, and 3 years, with blinded “clinical best-estimate” expert diagnosis at age 3. HR infants were enrolled based only on familial risk. LR infants, from community sources, had no first- or second-degree ASD relatives. All infants were born at 36–42 weeks, weighing ?2500 g, with no identifiable neurological, genetic, or severe sensory/motor disorders. Analytic phase I: semi-parametric group-based modeling to identify distinct developmental trajectories (n = 680; 487 HR; 193 LR); phase II: Trajectory membership in relation to 3-year diagnosis (n = 424; 310 HR; 114 LR). Three distinct trajectories emerged (1) inclining; (2) stable-average; (3) declining; trajectory membership predicted diagnosis (?2 = 99.40; p lt; .001). Most ASD cases were in stable-average (50.6%) or declining trajectories (33.8%); most non-ASD-HR infants were in inclining (51.9%) or stable-average (40.3%) trajectories. The majority of LR controls were in the inclining trajectory (78.9%). Within the declining trajectory, over half had ASD (57.8%), but 40% were non-ASD-HR infants. Declining/plateauing raw scores were associated with, but not exclusive to, ASD. Findings underscore the importance of monitoring the emergence of ASD symptoms and overall development in high-risk children. Evidence of developmental slowing or decline may be associated not only with ASD, but with other suboptimal outcomes, warranting careful clinical follow-up. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Jessica BRIAN, Auteur ; C. RONCADIN, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; I. DRMIC, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.1557-1566. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1557-1566 Mots-clés : High-risk siblings  Cognitive development  Infants  Toddlers  Developmental trajectories  ASD Index. décimale : PER Périodiques Résumé : This paper examined early developmental trajectories in a large, longitudinal sample at high-risk for ASD (‘HR’) and low-risk (‘LR’) controls, and the association of trajectories with 3-year diagnosis. Developmental assessments were conducted at 6, 12, 24 months, and 3 years, with blinded “clinical best-estimate” expert diagnosis at age 3. HR infants were enrolled based only on familial risk. LR infants, from community sources, had no first- or second-degree ASD relatives. All infants were born at 36–42 weeks, weighing ?2500 g, with no identifiable neurological, genetic, or severe sensory/motor disorders. Analytic phase I: semi-parametric group-based modeling to identify distinct developmental trajectories (n = 680; 487 HR; 193 LR); phase II: Trajectory membership in relation to 3-year diagnosis (n = 424; 310 HR; 114 LR). Three distinct trajectories emerged (1) inclining; (2) stable-average; (3) declining; trajectory membership predicted diagnosis (?2 = 99.40; p lt; .001). Most ASD cases were in stable-average (50.6%) or declining trajectories (33.8%); most non-ASD-HR infants were in inclining (51.9%) or stable-average (40.3%) trajectories. The majority of LR controls were in the inclining trajectory (78.9%). Within the declining trajectory, over half had ASD (57.8%), but 40% were non-ASD-HR infants. Declining/plateauing raw scores were associated with, but not exclusive to, ASD. Findings underscore the importance of monitoring the emergence of ASD symptoms and overall development in high-risk children. Evidence of developmental slowing or decline may be associated not only with ASD, but with other suboptimal outcomes, warranting careful clinical follow-up. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles / Teresa BENNETT in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2797-2808 Titre : Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles Type de document : Texte imprimé et/ou numérique Auteurs : Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; K. GEORGIADES, Auteur ; S. HANNA, Auteur ; M. JANUS, Auteur ; S. GEORGIADES, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; E. FOMBONNE, Auteur ; I. M. SMITH, Auteur ; P. MIRENDA, Auteur ; J. VOLDEN, Auteur ; C. WADDELL, Auteur ; W. ROBERTS, Auteur ; T. VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur Article en page(s) : p.2797-2808 Langues : Anglais (eng) Mots-clés : Social competence  Language impairment  DSM-5  Autism spectrum disorders  Longitudinal epidemiology Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and structural language impairment (LI) may be at risk of more adverse social-developmental outcomes. We examined trajectories of early social competence (using the Vineland-II) in 330 children aged 2–4 years recently diagnosed with ASD, and compared 3 subgroups classified by: language impairment (ASD/LI); intellectual disability (ASD/ID) and ASD without LI or ID (ASD/alone). Children with ASD/LI were significantly more socially impaired at baseline than the ASD/alone subgroup, and less impaired than those with ASD/ID. Growth in social competence was significantly slower for the ASD/ID group. Many preschool-aged children with ASD/LI at time of diagnosis resembled “late talkers” who appeared to catch up linguistically. Children with ASD/ID were more severely impaired and continued to lag further behind. En ligne : http://dx.doi.org/10.1007/s10803-014-2138-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles [Texte imprimé et/ou numérique] / Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; K. GEORGIADES, Auteur ; S. HANNA, Auteur ; M. JANUS, Auteur ; S. GEORGIADES, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; E. FOMBONNE, Auteur ; I. M. SMITH, Auteur ; P. MIRENDA, Auteur ; J. VOLDEN, Auteur ; C. WADDELL, Auteur ; W. ROBERTS, Auteur ; T. VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur . - p.2797-2808. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2797-2808 Mots-clés : Social competence  Language impairment  DSM-5  Autism spectrum disorders  Longitudinal epidemiology Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and structural language impairment (LI) may be at risk of more adverse social-developmental outcomes. We examined trajectories of early social competence (using the Vineland-II) in 330 children aged 2–4 years recently diagnosed with ASD, and compared 3 subgroups classified by: language impairment (ASD/LI); intellectual disability (ASD/ID) and ASD without LI or ID (ASD/alone). Children with ASD/LI were significantly more socially impaired at baseline than the ASD/alone subgroup, and less impaired than those with ASD/ID. Growth in social competence was significantly slower for the ASD/ID group. Many preschool-aged children with ASD/LI at time of diagnosis resembled “late talkers” who appeared to catch up linguistically. Children with ASD/ID were more severely impaired and continued to lag further behind. En ligne : http://dx.doi.org/10.1007/s10803-014-2138-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Parent and clinician agreement regarding early behavioral signs in 12- and 18-month-old infants at-risk of autism spectrum disorder / Lori-Ann R. SACREY in Autism Research, 11-3 (March 2018)  

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Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort / Lonnie ZWAIGENBAUM in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)  

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The Autism Parent Screen for Infants: Predicting risk of autism spectrum disorder based on parent-reported behavior observed at 6-24 months of age / Lori-Ann R. SACREY in Autism, 22-3 (April 2018)  

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Variability in Verbal and Nonverbal Communication in Infants at Risk for Autism Spectrum Disorder: Predictors and Outcomes / M. FRANCHINI in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

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