Developmental Changes in Brain Function Underlying Inhibitory Control in Autism Spectrum Disorders / Aarthi PADMANABHAN in Autism Research, 8-2 (April 2015)  

Public ISBD [article]  inAutism Research > 8-2 (April 2015) . - p.123-135 Titre : Developmental Changes in Brain Function Underlying Inhibitory Control in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Aarthi PADMANABHAN, Auteur ; Krista GARVER, Auteur ; Kirsten O'HEARN, Auteur ; Natalie NAWARAWONG, Auteur ; Ran LIU, Auteur ; Nancy MINSHEW, Auteur ; John SWEENEY, Auteur ; Beatriz LUNA, Auteur Article en page(s) : p.123-135 Langues : Anglais (eng) Mots-clés : autism  fMRI  inhibitory control  antisaccade  development  adolescence Index. décimale : PER Périodiques Résumé : The development of inhibitory control—the ability to suppress inappropriate actions in order to make goal-directed responses—is often impaired in autism spectrum disorders (ASD). In the present study, we examined whether the impairments in inhibitory control evident in ASD reflect—in part—differences in the development of the neural substrates of inhibitory control from adolescence into adulthood. We conducted a functional magnetic resonance imaging (fMRI) study on the anti-saccade task, a probe of inhibitory control, in high-functioning adolescents and adults with ASD compared to a matched group of typically developing (TD) individuals. The ASD group did not show the age-related improvements in behavioral performance from adolescence to adulthood evident in the typical group, consistent with previous behavioral work. The fMRI results indicated that much of the circuitry recruited by the ASD group was similar to the TD group. However, the ASD group demonstrated some unique patterns, including: (a) a failure to recruit the frontal eye field during response preparation in adolescence but comparable recruitment in adulthood; (b) greater recruitment of putamen in adolescence and precuneus in adolescence and adulthood than the TD group; and (c) decreased recruitment in the inferior parietal lobule relative to TD groups. Taken together, these results suggest that brain circuitry underlying inhibitory control develops differently from adolescence to adulthood in ASD. Specifically, there may be relative underdevelopment of brain processes underlying inhibitory control in ASD, which may lead to engagement of subcortical compensatory processes. En ligne : http://dx.doi.org/10.1002/aur.1398 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Developmental Changes in Brain Function Underlying Inhibitory Control in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Aarthi PADMANABHAN, Auteur ; Krista GARVER, Auteur ; Kirsten O'HEARN, Auteur ; Natalie NAWARAWONG, Auteur ; Ran LIU, Auteur ; Nancy MINSHEW, Auteur ; John SWEENEY, Auteur ; Beatriz LUNA, Auteur . - p.123-135. Langues : Anglais (eng) in Autism Research > 8-2 (April 2015) . - p.123-135 Mots-clés : autism  fMRI  inhibitory control  antisaccade  development  adolescence Index. décimale : PER Périodiques Résumé : The development of inhibitory control—the ability to suppress inappropriate actions in order to make goal-directed responses—is often impaired in autism spectrum disorders (ASD). In the present study, we examined whether the impairments in inhibitory control evident in ASD reflect—in part—differences in the development of the neural substrates of inhibitory control from adolescence into adulthood. We conducted a functional magnetic resonance imaging (fMRI) study on the anti-saccade task, a probe of inhibitory control, in high-functioning adolescents and adults with ASD compared to a matched group of typically developing (TD) individuals. The ASD group did not show the age-related improvements in behavioral performance from adolescence to adulthood evident in the typical group, consistent with previous behavioral work. The fMRI results indicated that much of the circuitry recruited by the ASD group was similar to the TD group. However, the ASD group demonstrated some unique patterns, including: (a) a failure to recruit the frontal eye field during response preparation in adolescence but comparable recruitment in adulthood; (b) greater recruitment of putamen in adolescence and precuneus in adolescence and adulthood than the TD group; and (c) decreased recruitment in the inferior parietal lobule relative to TD groups. Taken together, these results suggest that brain circuitry underlying inhibitory control develops differently from adolescence to adulthood in ASD. Specifically, there may be relative underdevelopment of brain processes underlying inhibitory control in ASD, which may lead to engagement of subcortical compensatory processes. En ligne : http://dx.doi.org/10.1002/aur.1398 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Fearful temperament in middle childhood predicts adolescent attention bias and anxiety symptoms: The moderating role of frontal EEG asymmetry / Ran LIU in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1335-1345 Titre : Fearful temperament in middle childhood predicts adolescent attention bias and anxiety symptoms: The moderating role of frontal EEG asymmetry Type de document : Texte imprimé et/ou numérique Auteurs : Ran LIU, Auteur ; Martha Ann BELL, Auteur Article en page(s) : p.1335-1345 Langues : Anglais (eng) Mots-clés : anxiety  attention bias to threat  fearful temperament  frontal EEG asymmetry Index. décimale : PER Périodiques Résumé : The current study provided first analyses of the moderating effect of baseline-to-task frontal EEG asymmetry on the associations between 9-year fearful temperament and adolescent attention bias to threat as well as anxiety symptoms. Participants include a community sample of 122 children (60 boys, 62 girls; Mage = 14.66 years; Range = 11.82-18.13 years). Baseline-to-task frontal EEG asymmetry at age 9 moderated the relation between fearful temperament at age 9 and adolescent anxiety symptoms. Specifically, fearful temperament predicted adolescent anxiety symptoms when children showed greater right activation from baseline to an executive function task, but not greater left activation. Baseline-to-task frontal EEG asymmetry moderated the association between fearful temperament and sustained (i.e., stimulus onset asynchrony is 1250 ms) but not automatic attention bias (i.e., stimulus onset asynchrony is 500 ms). Children with greater left frontal activation from baseline to task more efficiently direct attention away from threat. Adolescent automatic attention bias to threat was related to concurrent anxiety symptoms. These findings illustrate the importance of considering frontal EEG asymmetry to shape how fearful children process threat and to influence their behavioral problems. En ligne : http://dx.doi.org/10.1017/S0954579421001231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Fearful temperament in middle childhood predicts adolescent attention bias and anxiety symptoms: The moderating role of frontal EEG asymmetry [Texte imprimé et/ou numérique] / Ran LIU, Auteur ; Martha Ann BELL, Auteur . - p.1335-1345. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1335-1345 Mots-clés : anxiety  attention bias to threat  fearful temperament  frontal EEG asymmetry Index. décimale : PER Périodiques Résumé : The current study provided first analyses of the moderating effect of baseline-to-task frontal EEG asymmetry on the associations between 9-year fearful temperament and adolescent attention bias to threat as well as anxiety symptoms. Participants include a community sample of 122 children (60 boys, 62 girls; Mage = 14.66 years; Range = 11.82-18.13 years). Baseline-to-task frontal EEG asymmetry at age 9 moderated the relation between fearful temperament at age 9 and adolescent anxiety symptoms. Specifically, fearful temperament predicted adolescent anxiety symptoms when children showed greater right activation from baseline to an executive function task, but not greater left activation. Baseline-to-task frontal EEG asymmetry moderated the association between fearful temperament and sustained (i.e., stimulus onset asynchrony is 1250 ms) but not automatic attention bias (i.e., stimulus onset asynchrony is 500 ms). Children with greater left frontal activation from baseline to task more efficiently direct attention away from threat. Adolescent automatic attention bias to threat was related to concurrent anxiety symptoms. These findings illustrate the importance of considering frontal EEG asymmetry to shape how fearful children process threat and to influence their behavioral problems. En ligne : http://dx.doi.org/10.1017/S0954579421001231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Frontal EEG asymmetry moderates the associations between negative temperament and behavioral problems during childhood / Ran LIU in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.1016-1025 Titre : Frontal EEG asymmetry moderates the associations between negative temperament and behavioral problems during childhood Type de document : Texte imprimé et/ou numérique Auteurs : Ran LIU, Auteur ; Susan D. CALKINS, Auteur ; Martha Ann BELL, Auteur Article en page(s) : p.1016-1025 Langues : Anglais (eng) Mots-clés : externalizing  fearful inhibition  frontal EEG asymmetry  impulsivity-anger  internalizing Index. décimale : PER Périodiques Résumé : Fearful inhibition and impulsivity-anger significantly predict internalizing and externalizing problems, respectively. An important moderator that may affect these associations is frontal EEG asymmetry (FA). We examined how temperament and FA at 6 years interactively predicted behavioral problems at 9 years. A community sample of 186 children (93 boys, 93 girls) participated in the study. Results indicated that the effect of fearful inhibition on parent-reported internalizing problems increased as children exhibited greater right FA. The effect of impulsivity-anger on parent-reported externalizing problems increased as children showed greater left FA. Because FA was allowed to vary rather than children being dichotomized into membership in left FA and right FA groups, we observed that children’s FA contributed to the resilience process only when FA reached specific asymmetry levels. These findings highlight the importance of considering the different functions of FA in combination with specific dimensions of temperament in predicting children’s socioemotional outcomes. Clinical implications include providing suggestions for intervention services by demonstrating the role of FA in developing behavioral problems and inspiring research on whether it is possible to alter EEG activation and thus potentially improve developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579420000309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Frontal EEG asymmetry moderates the associations between negative temperament and behavioral problems during childhood [Texte imprimé et/ou numérique] / Ran LIU, Auteur ; Susan D. CALKINS, Auteur ; Martha Ann BELL, Auteur . - p.1016-1025. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.1016-1025 Mots-clés : externalizing  fearful inhibition  frontal EEG asymmetry  impulsivity-anger  internalizing Index. décimale : PER Périodiques Résumé : Fearful inhibition and impulsivity-anger significantly predict internalizing and externalizing problems, respectively. An important moderator that may affect these associations is frontal EEG asymmetry (FA). We examined how temperament and FA at 6 years interactively predicted behavioral problems at 9 years. A community sample of 186 children (93 boys, 93 girls) participated in the study. Results indicated that the effect of fearful inhibition on parent-reported internalizing problems increased as children exhibited greater right FA. The effect of impulsivity-anger on parent-reported externalizing problems increased as children showed greater left FA. Because FA was allowed to vary rather than children being dichotomized into membership in left FA and right FA groups, we observed that children’s FA contributed to the resilience process only when FA reached specific asymmetry levels. These findings highlight the importance of considering the different functions of FA in combination with specific dimensions of temperament in predicting children’s socioemotional outcomes. Clinical implications include providing suggestions for intervention services by demonstrating the role of FA in developing behavioral problems and inspiring research on whether it is possible to alter EEG activation and thus potentially improve developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579420000309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity / Ran LIU in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044 Titre : Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity Type de document : Texte imprimé et/ou numérique Auteurs : Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.1037-1044 Langues : Anglais (eng) Mots-clés : Air pollution  polycyclic aromatic hydrocarbons  prenatal  internalizing problems  shyness  anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity [Texte imprimé et/ou numérique] / Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur . - p.1037-1044. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044 Mots-clés : Air pollution  polycyclic aromatic hydrocarbons  prenatal  internalizing problems  shyness  anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development / Ran LIU in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1359-1367 Titre : Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development Type de document : Texte imprimé et/ou numérique Auteurs : Ran LIU, Auteur ; Mariah DESERISY, Auteur ; Nathan A. FOX, Auteur ; Julie B. HERBSTMAN, Auteur ; Virginia A. RAUH, Auteur ; Beatrice BEEBE, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.1359-1367 Langues : Anglais (eng) Mots-clés : Infant  Pregnancy  Male  Adolescent  Female  Humans  Prenatal Exposure Delayed Effects/psychology  Individuality  Air Pollution/adverse effects  Air Pollutants/adverse effects  Polycyclic Aromatic Hydrocarbons  Polycyclic aromatic hydrocarbons  infancy  maternal stress  reactivity and regulation  socioemotional development Index. décimale : PER Périodiques Résumé : BACKGROUND: Humans are ubiquitously exposed to air pollutants including polycyclic aromatic hydrocarbons (PAH). Although most studies of prenatal exposures have focused on psychopathology in childhood or adolescence, the effects of air pollutants on early emerging individual differences in reactivity and regulation are of growing concern. Our study is the first to report effects of prenatal exposure to PAH and maternal stress on infant reactivity and regulation. METHODS: Participants included 153 infants (74 girls and 79 boys). Prenatal exposure to PAH was measured via personal air monitoring during the third trimester of pregnancy. Maternal perceived stress was measured via self-report. We assessed infant orienting/regulation (OR), surgency (SE), and negative affectivity (NA) at 4 months using the Infant Behavior Questionnaire. We measured infant socioemotional outcomes at 12 months using the Brief Infant-Toddler Social & Emotional Assessment Questionnaire. RESULTS: Infants with higher prenatal PAH exposure and of mothers with higher stress had lower OR at 4 months, which predicted lower competence at 12 months. Infants with higher prenatal PAH exposure had lower SE at 4 months, which predicted more behavioral problems at 12 months. Prenatal exposure to PAH had no effects on infant NA at 4 months, although NA was associated with greater behavioral problems at 12 months. CONCLUSIONS: Infant reactivity and regulation, as early makers of child psychopathology, can facilitate timely and targeted screening and possibly prevention of disorders caused, in part, by environmental pollution. A multifaceted approach to improve environmental quality and reduce psychosocial stress is necessary to improve the developmental outcomes of children and most specially children from disadvantaged communities that disproportionately experience these environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13581 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development [Texte imprimé et/ou numérique] / Ran LIU, Auteur ; Mariah DESERISY, Auteur ; Nathan A. FOX, Auteur ; Julie B. HERBSTMAN, Auteur ; Virginia A. RAUH, Auteur ; Beatrice BEEBE, Auteur ; Amy E. MARGOLIS, Auteur . - p.1359-1367. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1359-1367 Mots-clés : Infant  Pregnancy  Male  Adolescent  Female  Humans  Prenatal Exposure Delayed Effects/psychology  Individuality  Air Pollution/adverse effects  Air Pollutants/adverse effects  Polycyclic Aromatic Hydrocarbons  Polycyclic aromatic hydrocarbons  infancy  maternal stress  reactivity and regulation  socioemotional development Index. décimale : PER Périodiques Résumé : BACKGROUND: Humans are ubiquitously exposed to air pollutants including polycyclic aromatic hydrocarbons (PAH). Although most studies of prenatal exposures have focused on psychopathology in childhood or adolescence, the effects of air pollutants on early emerging individual differences in reactivity and regulation are of growing concern. Our study is the first to report effects of prenatal exposure to PAH and maternal stress on infant reactivity and regulation. METHODS: Participants included 153 infants (74 girls and 79 boys). Prenatal exposure to PAH was measured via personal air monitoring during the third trimester of pregnancy. Maternal perceived stress was measured via self-report. We assessed infant orienting/regulation (OR), surgency (SE), and negative affectivity (NA) at 4 months using the Infant Behavior Questionnaire. We measured infant socioemotional outcomes at 12 months using the Brief Infant-Toddler Social & Emotional Assessment Questionnaire. RESULTS: Infants with higher prenatal PAH exposure and of mothers with higher stress had lower OR at 4 months, which predicted lower competence at 12 months. Infants with higher prenatal PAH exposure had lower SE at 4 months, which predicted more behavioral problems at 12 months. Prenatal exposure to PAH had no effects on infant NA at 4 months, although NA was associated with greater behavioral problems at 12 months. CONCLUSIONS: Infant reactivity and regulation, as early makers of child psychopathology, can facilitate timely and targeted screening and possibly prevention of disorders caused, in part, by environmental pollution. A multifaceted approach to improve environmental quality and reduce psychosocial stress is necessary to improve the developmental outcomes of children and most specially children from disadvantaged communities that disproportionately experience these environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13581 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

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