Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children / Luodi YU ; Lizhi BAN ; Aiwen YI ; Jing XIN ; Suping LI ; Suiping WANG ; Laurent MOTTRON in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.402-414 Titre : Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children : Autism Research Type de document : texte imprimé Auteurs : Luodi YU, Auteur ; Lizhi BAN, Auteur ; Aiwen YI, Auteur ; Jing XIN, Auteur ; Suping LI, Auteur ; Suiping WANG, Auteur ; Laurent MOTTRON, Auteur Article en page(s) : p.402-414 Langues : Anglais (eng) Mots-clés : auditory processing autism spectrum disorders EEG multivariate pattern analysis speech processing Index. décimale : PER Périodiques Résumé : ABSTRACT Child-directed speech (CDS), which amplifies acoustic and social features of speech during interactions with young children, promotes typical phonetic and language development. In autism, both behavioral and brain data indicate reduced sensitivity to human speech, which predicts absent, decreased, or atypical benefits of exaggerated speech signals such as CDS. This study investigates the impact of exaggerated fundamental frequency (F0) and voice-onset time on the neural processing of speech sounds in 22 Chinese-speaking autistic children aged 2 7 years old with a history of speech delays, compared with 25 typically developing (TD) peers. Electroencephalography (EEG) data were collected during passive listening to exaggerated and non-exaggerated syllables. A time-resolved multivariate pattern analysis (MVPA) was used to evaluate the potential effects of acoustic exaggeration on syllable discrimination in terms of neural decoding accuracy. For non-exaggerated syllables, neither the autism nor the TD group achieved above-chance decoding accuracy. In contrast, for exaggerated syllables, both groups achieved above-chance decoding, indicating significant syllable discrimination, with no difference in accuracy between the autism and TD groups. However, the temporal generalization patterns in the MVPA results revealed distinct neural mechanisms supporting syllable discrimination between the groups. Although the TD group demonstrated a left-hemisphere advantage for decoding and generalization, the autism group displayed similar decoding patterns between hemispheres. These findings highlight the potential of selective acoustic exaggeration to support speech learning in autistic children, underscoring the importance of tailored, sensory-based interventions. En ligne : https://doi.org/10.1002/aur.3301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children : Autism Research [texte imprimé] / Luodi YU, Auteur ; Lizhi BAN, Auteur ; Aiwen YI, Auteur ; Jing XIN, Auteur ; Suping LI, Auteur ; Suiping WANG, Auteur ; Laurent MOTTRON, Auteur . - p.402-414. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.402-414 Mots-clés : auditory processing autism spectrum disorders EEG multivariate pattern analysis speech processing Index. décimale : PER Périodiques Résumé : ABSTRACT Child-directed speech (CDS), which amplifies acoustic and social features of speech during interactions with young children, promotes typical phonetic and language development. In autism, both behavioral and brain data indicate reduced sensitivity to human speech, which predicts absent, decreased, or atypical benefits of exaggerated speech signals such as CDS. This study investigates the impact of exaggerated fundamental frequency (F0) and voice-onset time on the neural processing of speech sounds in 22 Chinese-speaking autistic children aged 2 7 years old with a history of speech delays, compared with 25 typically developing (TD) peers. Electroencephalography (EEG) data were collected during passive listening to exaggerated and non-exaggerated syllables. A time-resolved multivariate pattern analysis (MVPA) was used to evaluate the potential effects of acoustic exaggeration on syllable discrimination in terms of neural decoding accuracy. For non-exaggerated syllables, neither the autism nor the TD group achieved above-chance decoding accuracy. In contrast, for exaggerated syllables, both groups achieved above-chance decoding, indicating significant syllable discrimination, with no difference in accuracy between the autism and TD groups. However, the temporal generalization patterns in the MVPA results revealed distinct neural mechanisms supporting syllable discrimination between the groups. Although the TD group demonstrated a left-hemisphere advantage for decoding and generalization, the autism group displayed similar decoding patterns between hemispheres. These findings highlight the potential of selective acoustic exaggeration to support speech learning in autistic children, underscoring the importance of tailored, sensory-based interventions. En ligne : https://doi.org/10.1002/aur.3301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Brief Report: Atypical Visual Exploration in Autism Spectrum Disorder Cannot be Attributed to the Amygdala / Suiping WANG in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2605-2611 Titre : Brief Report: Atypical Visual Exploration in Autism Spectrum Disorder Cannot be Attributed to the Amygdala Type de document : texte imprimé Auteurs : Suiping WANG, Auteur Article en page(s) : p.2605-2611 Langues : Anglais (eng) Mots-clés : Amygdala  Attention  Autism spectrum disorder  Eye tracking  Saliency Index. décimale : PER Périodiques Résumé : Prior studies have emphasized the contribution of aberrant amygdala structure and function in social aspects of autism. However, it remains largely unknown whether amygdala dysfunction directly impairs visual attention and exploration as has been observed in people with autism spectrum disorders (ASD). Here, gaze patterns were directly compared between a rare amygdala lesion patient and adults with ASD when they freely viewed static images of complex natural scenes. The amygdala lesion patient showed a gaze pattern that was more similar to controls rather than that of the ASD group, which was independent of image content (social vs. objects) or complexity. This finding was further corroborated by analysis of temporal aspects of the gaze patterns and semantic category analysis. Together, the present results suggest that abnormal visual exploration observed in people with ASD is not likely primarily attributed to the amygdala. En ligne : https://dx.doi.org/10.1007/s10803-019-04009-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Brief Report: Atypical Visual Exploration in Autism Spectrum Disorder Cannot be Attributed to the Amygdala [texte imprimé] / Suiping WANG, Auteur . - p.2605-2611. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2605-2611 Mots-clés : Amygdala  Attention  Autism spectrum disorder  Eye tracking  Saliency Index. décimale : PER Périodiques Résumé : Prior studies have emphasized the contribution of aberrant amygdala structure and function in social aspects of autism. However, it remains largely unknown whether amygdala dysfunction directly impairs visual attention and exploration as has been observed in people with autism spectrum disorders (ASD). Here, gaze patterns were directly compared between a rare amygdala lesion patient and adults with ASD when they freely viewed static images of complex natural scenes. The amygdala lesion patient showed a gaze pattern that was more similar to controls rather than that of the ASD group, which was independent of image content (social vs. objects) or complexity. This finding was further corroborated by analysis of temporal aspects of the gaze patterns and semantic category analysis. Together, the present results suggest that abnormal visual exploration observed in people with ASD is not likely primarily attributed to the amygdala. En ligne : https://dx.doi.org/10.1007/s10803-019-04009-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood / Inês POTE in Autism Research, 12-4 (April 2019)  

Public ISBD [article]  inAutism Research > 12-4 (April 2019) . - p.614-627 Titre : Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood Type de document : texte imprimé Auteurs : Inês POTE, Auteur ; Suiping WANG, Auteur ; Vaheshta SETHNA, Auteur ; Anna BLASI, Auteur ; Eileen DALY, Auteur ; Maria KUKLISOVA-MURGASOVA, Auteur ; Sarah LLOYD-FOX, Auteur ; Evelyne MERCURE, Auteur ; Paula BUSUULWA, Auteur ; Vladimira STOENCHEVA, Auteur ; Tony CHARMAN, Auteur ; Steven C.R. WILLIAMS, Auteur ; Mark Henry JOHNSON, Auteur ; Declan G.M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur Article en page(s) : p.614-627 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cerebellum  familial risk  infants  magnetic resonance imaging-structural  mother-infant interaction  subcortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically developing siblings. Reports of differences in brain anatomy and function in high-risk infants which predict later autistic behaviors are emerging, but although cerebellar and subcortical brain regions have been frequently implicated in ASD, no high-risk study has examined these regions. Therefore, in this study, we compared regional MRI volumes across the whole brain in 4-6-month-old infants with (high-risk, n = 24) and without (low-risk, n = 26) a sibling with ASD. Within the high-risk group, we also examined whether any regional differences observed were associated with autistic behaviors at 36 months. We found that high-risk infants had significantly larger cerebellar and subcortical volumes at 4-6-months of age, relative to low-risk infants; and that larger volumes in high-risk infants were linked to more repetitive behaviors at 36 months. Our preliminary observations require replication in longitudinal studies of larger samples. If correct, they suggest that the early subcortex and cerebellum volumes may be predictive biomarkers for childhood repetitive behaviors. Autism Res 2019, 12: 614-627. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published byWiley Periodicals, Inc. LAY SUMMARY: Individuals with a family history of autism spectrum disorder (ASD) are at risk of ASD and related developmental difficulties. This study revealed that 4-6-month-old infants at high-risk of ASD have larger cerebellum and subcortical volumes than low-risk infants, and that larger volumes in high-risk infants are associated with more repetitive behaviors in childhood. En ligne : https://dx.doi.org/10.1002/aur.2083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood [texte imprimé] / Inês POTE, Auteur ; Suiping WANG, Auteur ; Vaheshta SETHNA, Auteur ; Anna BLASI, Auteur ; Eileen DALY, Auteur ; Maria KUKLISOVA-MURGASOVA, Auteur ; Sarah LLOYD-FOX, Auteur ; Evelyne MERCURE, Auteur ; Paula BUSUULWA, Auteur ; Vladimira STOENCHEVA, Auteur ; Tony CHARMAN, Auteur ; Steven C.R. WILLIAMS, Auteur ; Mark Henry JOHNSON, Auteur ; Declan G.M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur . - p.614-627. Langues : Anglais (eng) in Autism Research > 12-4 (April 2019) . - p.614-627 Mots-clés : autism spectrum disorder  cerebellum  familial risk  infants  magnetic resonance imaging-structural  mother-infant interaction  subcortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically developing siblings. Reports of differences in brain anatomy and function in high-risk infants which predict later autistic behaviors are emerging, but although cerebellar and subcortical brain regions have been frequently implicated in ASD, no high-risk study has examined these regions. Therefore, in this study, we compared regional MRI volumes across the whole brain in 4-6-month-old infants with (high-risk, n = 24) and without (low-risk, n = 26) a sibling with ASD. Within the high-risk group, we also examined whether any regional differences observed were associated with autistic behaviors at 36 months. We found that high-risk infants had significantly larger cerebellar and subcortical volumes at 4-6-months of age, relative to low-risk infants; and that larger volumes in high-risk infants were linked to more repetitive behaviors at 36 months. Our preliminary observations require replication in longitudinal studies of larger samples. If correct, they suggest that the early subcortex and cerebellum volumes may be predictive biomarkers for childhood repetitive behaviors. Autism Res 2019, 12: 614-627. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published byWiley Periodicals, Inc. LAY SUMMARY: Individuals with a family history of autism spectrum disorder (ASD) are at risk of ASD and related developmental difficulties. This study revealed that 4-6-month-old infants at high-risk of ASD have larger cerebellum and subcortical volumes than low-risk infants, and that larger volumes in high-risk infants are associated with more repetitive behaviors in childhood. En ligne : https://dx.doi.org/10.1002/aur.2083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis / Jishui ZHANG in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.34-43 Titre : McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis Type de document : texte imprimé Auteurs : Jishui ZHANG, Auteur ; Yaxuan MENG, Auteur ; Jason HE, Auteur ; Yutao XIANG, Auteur ; Chenggang WU, Auteur ; Suiping WANG, Auteur ; Zhen YUAN, Auteur Article en page(s) : p.34-43 Langues : Anglais (eng) Mots-clés : Age  Autism spectrum disorder  McGurk effect  Task scoring method  Typically developing controls Index. décimale : PER Périodiques Résumé : By synthesizing existing behavioural studies through a meta-analytic approach, the current study compared the performances of Autism spectrum disorder (ASD) and typically developing groups in audiovisual speech integration and investigated potential moderators that might contribute to the heterogeneity of the existing findings. In total, nine studies were included in the current study, and the pooled overall difference between the two groups was significant, g = - 0.835 (p < 0.001; 95% CI - 1.155 to - 0.516). Age and task scoring method were found to be associated with the inconsistencies of the findings reported by previous studies. These findings indicate that individuals with ASD show weaker McGurk effect than typically developing controls. En ligne : http://dx.doi.org/10.1007/s10803-018-3680-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis [texte imprimé] / Jishui ZHANG, Auteur ; Yaxuan MENG, Auteur ; Jason HE, Auteur ; Yutao XIANG, Auteur ; Chenggang WU, Auteur ; Suiping WANG, Auteur ; Zhen YUAN, Auteur . - p.34-43. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.34-43 Mots-clés : Age  Autism spectrum disorder  McGurk effect  Task scoring method  Typically developing controls Index. décimale : PER Périodiques Résumé : By synthesizing existing behavioural studies through a meta-analytic approach, the current study compared the performances of Autism spectrum disorder (ASD) and typically developing groups in audiovisual speech integration and investigated potential moderators that might contribute to the heterogeneity of the existing findings. In total, nine studies were included in the current study, and the pooled overall difference between the two groups was significant, g = - 0.835 (p < 0.001; 95% CI - 1.155 to - 0.516). Age and task scoring method were found to be associated with the inconsistencies of the findings reported by previous studies. These findings indicate that individuals with ASD show weaker McGurk effect than typically developing controls. En ligne : http://dx.doi.org/10.1007/s10803-018-3680-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Neural coding of formant-exaggerated speech and nonspeech in children with and without autism spectrum disorders / Fei CHEN in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1357-1374 Titre : Neural coding of formant-exaggerated speech and nonspeech in children with and without autism spectrum disorders Type de document : texte imprimé Auteurs : Fei CHEN, Auteur ; Hongyang ZHANG, Auteur ; Hongwei DING, Auteur ; Suiping WANG, Auteur ; Gang PENG, Auteur ; Yang ZHANG, Auteur Année de publication : 2021 Article en page(s) : p.1357-1374 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications  Child  Child, Preschool  Evoked Potentials  Humans  Language Development  Phonetics  Speech  Speech Perception  Asd  adult-directed speech  formant exaggeration  infant-directed speech  nonspeech Index. décimale : PER Périodiques Résumé : The presence of vowel exaggeration in infant-directed speech (IDS) may adapt to the age-appropriate demands in speech and language acquisition. Previous studies have provided behavioral evidence of atypical auditory processing towards IDS in children with autism spectrum disorders (ASD), while the underlying neurophysiological mechanisms remain unknown. This event-related potential (ERP) study investigated the neural coding of formant-exaggerated speech and nonspeech in 24 4- to 11-year-old children with ASD and 24 typically-developing (TD) peers. The EEG data were recorded using an alternating block design, in which each stimulus type (exaggerated/non-exaggerated sound) was presented with equal probability. ERP waveform analysis revealed an enhanced P1 for vowel formant exaggeration in the TD group but not in the ASD group. This speech-specific atypical processing in ASD was not found for the nonspeech stimuli which showed similar P1 enhancement in both ASD and TD groups. Moreover, the time-frequency analysis indicated that children with ASD showed differences in neural synchronization in the delta-theta bands for processing acoustic formant changes embedded in nonspeech. Collectively, the results add substantiating neurophysiological evidence (i.e., a lack of neural enhancement effect of vowel exaggeration) for atypical auditory processing of IDS in children with ASD, which may exert a negative effect on phonetic encoding and language learning. LAY SUMMARY: Atypical responses to motherese might act as a potential early marker of risk for children with ASD. This study investigated the neural responses to such socially relevant stimuli in the ASD brain, and the results suggested a lack of neural enhancement responding to the motherese even in individuals without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2509 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Neural coding of formant-exaggerated speech and nonspeech in children with and without autism spectrum disorders [texte imprimé] / Fei CHEN, Auteur ; Hongyang ZHANG, Auteur ; Hongwei DING, Auteur ; Suiping WANG, Auteur ; Gang PENG, Auteur ; Yang ZHANG, Auteur . - 2021 . - p.1357-1374. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1357-1374 Mots-clés : Autism Spectrum Disorder/complications  Child  Child, Preschool  Evoked Potentials  Humans  Language Development  Phonetics  Speech  Speech Perception  Asd  adult-directed speech  formant exaggeration  infant-directed speech  nonspeech Index. décimale : PER Périodiques Résumé : The presence of vowel exaggeration in infant-directed speech (IDS) may adapt to the age-appropriate demands in speech and language acquisition. Previous studies have provided behavioral evidence of atypical auditory processing towards IDS in children with autism spectrum disorders (ASD), while the underlying neurophysiological mechanisms remain unknown. This event-related potential (ERP) study investigated the neural coding of formant-exaggerated speech and nonspeech in 24 4- to 11-year-old children with ASD and 24 typically-developing (TD) peers. The EEG data were recorded using an alternating block design, in which each stimulus type (exaggerated/non-exaggerated sound) was presented with equal probability. ERP waveform analysis revealed an enhanced P1 for vowel formant exaggeration in the TD group but not in the ASD group. This speech-specific atypical processing in ASD was not found for the nonspeech stimuli which showed similar P1 enhancement in both ASD and TD groups. Moreover, the time-frequency analysis indicated that children with ASD showed differences in neural synchronization in the delta-theta bands for processing acoustic formant changes embedded in nonspeech. Collectively, the results add substantiating neurophysiological evidence (i.e., a lack of neural enhancement effect of vowel exaggeration) for atypical auditory processing of IDS in children with ASD, which may exert a negative effect on phonetic encoding and language learning. LAY SUMMARY: Atypical responses to motherese might act as a potential early marker of risk for children with ASD. This study investigated the neural responses to such socially relevant stimuli in the ASD brain, and the results suggested a lack of neural enhancement responding to the motherese even in individuals without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2509 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Pitch Processing in Tonal-Language-Speaking Children with Autism: An Event-Related Potential Study / Luodi YU in Journal of Autism and Developmental Disorders, 45-11 (November 2015)  

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Promoting a Collective Voice from Parents, Educators and Allied Health Professionals on the Educational Needs of Students on the Autism Spectrum / Beth SAGGERS in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

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Reduced Neural Specialization for Word-level Linguistic Prosody in Children with Autism / Luodi YU in Journal of Autism and Developmental Disorders, 53-11 (November 2023)  

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Sex differentiation of brain structures in autism: Findings from a gray matter asymmetry study / Zhizhou DENG in Autism Research, 14-6 (June 2021)  

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