Enhanced motor noise in an autism subtype with poor motor skills / Veronica MANDELLI in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 36p. Titre : Enhanced motor noise in an autism subtype with poor motor skills Type de document : Texte imprimé et/ou numérique Auteurs : Veronica MANDELLI, Auteur ; Isotta LANDI, Auteur ; Silvia Busti CECCARELLI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur ; Alessandro D'AUSILIO, Auteur ; Luciano FADIGA, Auteur ; Alessandro CRIPPA, Auteur ; Michael V. LOMBARDO, Auteur Article en page(s) : 36p. Langues : Anglais (eng) Mots-clés : Humans  Child  Male  Female  Adolescent  Motor Skills  Autistic Disorder/physiopathology  Child, Preschool  Biomechanical Phenomena  Clustering  Kinematics  Motor  Stratification  Subtypes  competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor difficulties are common in many, but not all, autistic individuals. These difficulties can co-occur with other problems, such as delays in language, intellectual, and adaptive functioning. Biological mechanisms underpinning such difficulties are less well understood. Poor motor skills tend to be more common in individuals carrying highly penetrant rare genetic mutations. Such mechanisms may have downstream consequences of altering neurophysiological excitation-inhibition balance and lead to enhanced behavioral motor noise. METHODS: This study combined publicly available and in-house datasets of autistic (n = 156), typically-developing (TD, n = 149), and developmental coordination disorder (DCD, n = 23) children (age 3-16 years). Autism motor subtypes were identified based on patterns of motor abilities measured from the Movement Assessment Battery for Children 2nd edition. Stability-based relative clustering validation was used to identify autism motor subtypes and evaluate generalization accuracy in held-out data. Autism motor subtypes were tested for differences in motor noise, operationalized as the degree of dissimilarity between repeated motor kinematic trajectories recorded during a simple reach-to-drop task. RESULTS: Relatively 'high' (n = 87) versus 'low' (n = 69) autism motor subtypes could be detected and which generalize with 89% accuracy in held-out data. The relatively 'low' subtype was lower in general intellectual ability and older at age of independent walking, but did not differ in age at first words or autistic traits or symptomatology. Motor noise was considerably higher in the 'low' subtype compared to 'high' (Cohen's d = 0.77) or TD children (Cohen's d = 0.85), but similar between autism 'high' and TD children (Cohen's d = 0.08). Enhanced motor noise in the 'low' subtype was also most pronounced during the feedforward phase of reaching actions. LIMITATIONS: The sample size of this work is limited. Future work in larger samples along with independent replication is important. Motor noise was measured only on one specific motor task. Thus, a more comprehensive assessment of motor noise on many other motor tasks is needed. CONCLUSIONS: Autism can be split into at least two discrete motor subtypes that are characterized by differing levels of motor noise. This suggests that autism motor subtypes may be underpinned by different biological mechanisms. En ligne : https://dx.doi.org/10.1186/s13229-024-00618-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Enhanced motor noise in an autism subtype with poor motor skills [Texte imprimé et/ou numérique] / Veronica MANDELLI, Auteur ; Isotta LANDI, Auteur ; Silvia Busti CECCARELLI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur ; Alessandro D'AUSILIO, Auteur ; Luciano FADIGA, Auteur ; Alessandro CRIPPA, Auteur ; Michael V. LOMBARDO, Auteur . - 36p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 36p. Mots-clés : Humans  Child  Male  Female  Adolescent  Motor Skills  Autistic Disorder/physiopathology  Child, Preschool  Biomechanical Phenomena  Clustering  Kinematics  Motor  Stratification  Subtypes  competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor difficulties are common in many, but not all, autistic individuals. These difficulties can co-occur with other problems, such as delays in language, intellectual, and adaptive functioning. Biological mechanisms underpinning such difficulties are less well understood. Poor motor skills tend to be more common in individuals carrying highly penetrant rare genetic mutations. Such mechanisms may have downstream consequences of altering neurophysiological excitation-inhibition balance and lead to enhanced behavioral motor noise. METHODS: This study combined publicly available and in-house datasets of autistic (n = 156), typically-developing (TD, n = 149), and developmental coordination disorder (DCD, n = 23) children (age 3-16 years). Autism motor subtypes were identified based on patterns of motor abilities measured from the Movement Assessment Battery for Children 2nd edition. Stability-based relative clustering validation was used to identify autism motor subtypes and evaluate generalization accuracy in held-out data. Autism motor subtypes were tested for differences in motor noise, operationalized as the degree of dissimilarity between repeated motor kinematic trajectories recorded during a simple reach-to-drop task. RESULTS: Relatively 'high' (n = 87) versus 'low' (n = 69) autism motor subtypes could be detected and which generalize with 89% accuracy in held-out data. The relatively 'low' subtype was lower in general intellectual ability and older at age of independent walking, but did not differ in age at first words or autistic traits or symptomatology. Motor noise was considerably higher in the 'low' subtype compared to 'high' (Cohen's d = 0.77) or TD children (Cohen's d = 0.85), but similar between autism 'high' and TD children (Cohen's d = 0.08). Enhanced motor noise in the 'low' subtype was also most pronounced during the feedforward phase of reaching actions. LIMITATIONS: The sample size of this work is limited. Future work in larger samples along with independent replication is important. Motor noise was measured only on one specific motor task. Thus, a more comprehensive assessment of motor noise on many other motor tasks is needed. CONCLUSIONS: Autism can be split into at least two discrete motor subtypes that are characterized by differing levels of motor noise. This suggests that autism motor subtypes may be underpinned by different biological mechanisms. En ligne : https://dx.doi.org/10.1186/s13229-024-00618-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Further evidence of complex motor dysfunction in drug naïve children with autism using automatic motion analysis of gait / Maria NOBILE in Autism, 15-3 (May 2011)  

Public ISBD [article]  inAutism > 15-3 (May 2011) . - p.263-283 Titre : Further evidence of complex motor dysfunction in drug naïve children with autism using automatic motion analysis of gait Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Paolo PEREGO, Auteur ; Luigi PICCININI, Auteur ; Elisa MANI, Auteur ; Agnese ROSSI, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur Année de publication : 2011 Article en page(s) : p.263-283 Langues : Anglais (eng) Mots-clés : autism  gait analysis  jerk  locomotion system  motor dysfunction Index. décimale : PER Périodiques Résumé : In order to increase the knowledge of locomotor disturbances in children with autism, and of the mechanism underlying them, the objective of this exploratory study was to reliably and quantitatively evaluate linear gait parameters (spatio-temporal and kinematic parameters), upper body kinematic parameters, walk orientation and smoothness using an automatic motion analyser (ELITE systems) in drug naïve children with Autistic Disorder (AD) and healthy controls. The children with AD showed a stiffer gait in which the usual fluidity of walking was lost, trunk postural abnormalities, highly significant difficulties to maintain a straight line and a marked loss of smoothness (increase of jerk index), compared to the healthy controls. As a whole, these data suggest a complex motor dysfunction involving both the cortical and the subcortical area or, maybe, a possible deficit in the integration of sensory-motor information within motor networks (i.e., anomalous connections within the fronto-cerebello-thalamo-frontal network). Although the underlying neural structures involved remain to be better defined, these data may contribute to highlighting the central role of motor impairment in autism and suggest the usefulness of taking into account motor difficulties when developing new diagnostic and rehabilitation programs. En ligne : http://dx.doi.org/10.1177/1362361309356929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 [article] Further evidence of complex motor dysfunction in drug naïve children with autism using automatic motion analysis of gait [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Paolo PEREGO, Auteur ; Luigi PICCININI, Auteur ; Elisa MANI, Auteur ; Agnese ROSSI, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur . - 2011 . - p.263-283. Langues : Anglais (eng) in Autism > 15-3 (May 2011) . - p.263-283 Mots-clés : autism  gait analysis  jerk  locomotion system  motor dysfunction Index. décimale : PER Périodiques Résumé : In order to increase the knowledge of locomotor disturbances in children with autism, and of the mechanism underlying them, the objective of this exploratory study was to reliably and quantitatively evaluate linear gait parameters (spatio-temporal and kinematic parameters), upper body kinematic parameters, walk orientation and smoothness using an automatic motion analyser (ELITE systems) in drug naïve children with Autistic Disorder (AD) and healthy controls. The children with AD showed a stiffer gait in which the usual fluidity of walking was lost, trunk postural abnormalities, highly significant difficulties to maintain a straight line and a marked loss of smoothness (increase of jerk index), compared to the healthy controls. As a whole, these data suggest a complex motor dysfunction involving both the cortical and the subcortical area or, maybe, a possible deficit in the integration of sensory-motor information within motor networks (i.e., anomalous connections within the fronto-cerebello-thalamo-frontal network). Although the underlying neural structures involved remain to be better defined, these data may contribute to highlighting the central role of motor impairment in autism and suggest the usefulness of taking into account motor difficulties when developing new diagnostic and rehabilitation programs. En ligne : http://dx.doi.org/10.1177/1362361309356929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder / Alessandro CRIPPA in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1481-1491 Titre : A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur Article en page(s) : p.1481-1491 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11?years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder [Texte imprimé et/ou numérique] / Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur . - p.1481-1491. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1481-1491 Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11?years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder / Alessandro CRIPPA in Autism, 26-5 (July 2022)  

Public ISBD [article]  inAutism > 26-5 (July 2022) . - p.1481-1491 Titre : A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur Article en page(s) : p.1481-1491 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  autism spectrum disorder  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder [Texte imprimé et/ou numérique] / Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur . - p.1481-1491. Langues : Anglais (eng) in Autism > 26-5 (July 2022) . - p.1481-1491 Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  autism spectrum disorder  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

A multimodal approach can identify specific motor profiles in autism and attention-deficit/hyperactivity disorder / Stefano DE FRANCESCO in Autism Research, 16-8 (August 2023)  

Public ISBD [article]  inAutism Research > 16-8 (August 2023) . - p.1550-1560 Titre : A multimodal approach can identify specific motor profiles in autism and attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Stefano DE FRANCESCO, Auteur ; Luisa MORELLO, Auteur ; Mariachiara FIORAVANTI, Auteur ; Cristina CASSARO, Auteur ; Silvia GRAZIOLI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur Article en page(s) : p.1550-1560 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract It is still unclear whether and to what extent the motor difficulties are specific to autism. This study aimed to determine whether a multimodal assessment of motor skills could accurately discriminate autistic children from attention-deficit/hyperactivity disorder (ADHD) and typically developing (TD) peers. Seventy-five children, aged 7-13, equally divided into three groups, were assessed with the developmental coordination disorder questionnaire (DCDQ), the movement assessment battery for children 2 (MABC2), the sensorimotor subtests of NEPSY-II, and the kinematic analysis of a reach-to-drop task. Principal component analysis (PCA) on DCDQ subscales revealed one factor-Caregiver Report-, whereas MABC2/NEPSY-II scores identified three factors-namely, Object Interception and Balance, Motor Imitation, and Fine-Motor Skills-. Lastly, PCA on kinematic variables identified four factors: PC1, loaded by the parameters of velocity and acceleration throughout the task, PC2 and PC3 involved the temporal parameters of the two submovements, and PC4 accounted for the wrist inclination at ball drop. When comparing autistic and TD children, Caregiver Report and Motor Imitation factors predicted membership with 87.2% of accuracy. In the model comparing ADHD and TD groups, Caregiver Report and Fine-Motor Skills predicted membership with an accuracy of 73.5%. In the last model, the Object Interception and Balance factor differentiated autistic children from ADHD with an accuracy of 73.5%. In line with our previous findings, kinematics did not differentiate school-aged autistic children from ADHD and TD peers. The present findings show that specific motor profiles in autism and ADHD can be isolated with a multimodal investigation of motor skills. En ligne : https://doi.org/10.1002/aur.2989 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] A multimodal approach can identify specific motor profiles in autism and attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Stefano DE FRANCESCO, Auteur ; Luisa MORELLO, Auteur ; Mariachiara FIORAVANTI, Auteur ; Cristina CASSARO, Auteur ; Silvia GRAZIOLI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur . - p.1550-1560. Langues : Anglais (eng) in Autism Research > 16-8 (August 2023) . - p.1550-1560 Index. décimale : PER Périodiques Résumé : Abstract It is still unclear whether and to what extent the motor difficulties are specific to autism. This study aimed to determine whether a multimodal assessment of motor skills could accurately discriminate autistic children from attention-deficit/hyperactivity disorder (ADHD) and typically developing (TD) peers. Seventy-five children, aged 7-13, equally divided into three groups, were assessed with the developmental coordination disorder questionnaire (DCDQ), the movement assessment battery for children 2 (MABC2), the sensorimotor subtests of NEPSY-II, and the kinematic analysis of a reach-to-drop task. Principal component analysis (PCA) on DCDQ subscales revealed one factor-Caregiver Report-, whereas MABC2/NEPSY-II scores identified three factors-namely, Object Interception and Balance, Motor Imitation, and Fine-Motor Skills-. Lastly, PCA on kinematic variables identified four factors: PC1, loaded by the parameters of velocity and acceleration throughout the task, PC2 and PC3 involved the temporal parameters of the two submovements, and PC4 accounted for the wrist inclination at ball drop. When comparing autistic and TD children, Caregiver Report and Motor Imitation factors predicted membership with 87.2% of accuracy. In the model comparing ADHD and TD groups, Caregiver Report and Fine-Motor Skills predicted membership with an accuracy of 73.5%. In the last model, the Object Interception and Balance factor differentiated autistic children from ADHD with an accuracy of 73.5%. In line with our previous findings, kinematics did not differentiate school-aged autistic children from ADHD and TD peers. The present findings show that specific motor profiles in autism and ADHD can be isolated with a multimodal investigation of motor skills. En ligne : https://doi.org/10.1002/aur.2989 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence / Maria NOBILE in Development and Psychopathology, 19-4 (Fall 2007)  

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The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years / Maria NOBILE in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

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Use of Machine Learning to Identify Children with Autism and Their Motor Abnormalities / Alessandro CRIPPA in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

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