Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis / Mirko ULJAREVIC in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1030-1042 Titre : Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis Type de document : Texte imprimé et/ou numérique Auteurs : Mirko ULJAREVIC, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Emma J. GLASSON, Auteur ; Murray T. MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Gail A. ALVARES, Auteur ; John WRAY, Auteur ; Susan R LEEKAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1030-1042 Langues : Anglais (eng) Mots-clés : Repetitive behaviours  autism  social and communication impairments Index. décimale : PER Périodiques Résumé : OBJECTIVE: Restricted and repetitive pattern of behaviours and interests (RRB) are a cardinal feature of autism spectrum disorder (ASD), but there remains uncertainty about how these diverse behaviours vary according to individual characteristics. This study provided the largest exploration to date of the relationship between Repetitive Motor Behaviours, Rigidity/Insistence on Sameness and Circumscribed Interests with other individual characteristics in newly diagnosed individuals with ASD. METHOD: Participants (N = 3,647; 17.7% females; Mage = 6.6 years [SD = 4.7]) were part of the Western Australian (WA) Register for ASD, an independent, prospective collection of demographic and diagnostic data of newly diagnosed cases of ASD in WA. Diagnosticians rated each of the DSM-IV-TR criteria on a 4-point Likert severity scale, and here we focused on the Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests symptoms. RESULTS: The associations between RRB domains, indexed by Kendall's Tau, were weak, ranging from non-significant for both Circumscribed Interests and Repetitive Motor Behaviours to significant (.20) for Insistence on Sameness and Repetitive Motor Behaviours. Older age at diagnosis was significantly associated with lower Circumscribed Interests and significantly associated with higher Insistence on Sameness and Repetitive Motor Behaviours. Male sex was significantly associated with higher Repetitive Motor Behaviours but not Insistence on Sameness or Circumscribed Interests. CONCLUSIONS: The pattern of associations identified in this study provides suggestive evidence for the distinctiveness of Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests, highlighting the potential utility of RRB domains for stratifying the larger ASD population into smaller, more phenotypically homogeneous subgroups that can help to facilitate efforts to understand diverse ASD aetiology and inform design of future interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis [Texte imprimé et/ou numérique] / Mirko ULJAREVIC, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Emma J. GLASSON, Auteur ; Murray T. MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Gail A. ALVARES, Auteur ; John WRAY, Auteur ; Susan R LEEKAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1030-1042. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1030-1042 Mots-clés : Repetitive behaviours  autism  social and communication impairments Index. décimale : PER Périodiques Résumé : OBJECTIVE: Restricted and repetitive pattern of behaviours and interests (RRB) are a cardinal feature of autism spectrum disorder (ASD), but there remains uncertainty about how these diverse behaviours vary according to individual characteristics. This study provided the largest exploration to date of the relationship between Repetitive Motor Behaviours, Rigidity/Insistence on Sameness and Circumscribed Interests with other individual characteristics in newly diagnosed individuals with ASD. METHOD: Participants (N = 3,647; 17.7% females; Mage = 6.6 years [SD = 4.7]) were part of the Western Australian (WA) Register for ASD, an independent, prospective collection of demographic and diagnostic data of newly diagnosed cases of ASD in WA. Diagnosticians rated each of the DSM-IV-TR criteria on a 4-point Likert severity scale, and here we focused on the Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests symptoms. RESULTS: The associations between RRB domains, indexed by Kendall's Tau, were weak, ranging from non-significant for both Circumscribed Interests and Repetitive Motor Behaviours to significant (.20) for Insistence on Sameness and Repetitive Motor Behaviours. Older age at diagnosis was significantly associated with lower Circumscribed Interests and significantly associated with higher Insistence on Sameness and Repetitive Motor Behaviours. Male sex was significantly associated with higher Repetitive Motor Behaviours but not Insistence on Sameness or Circumscribed Interests. CONCLUSIONS: The pattern of associations identified in this study provides suggestive evidence for the distinctiveness of Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests, highlighting the potential utility of RRB domains for stratifying the larger ASD population into smaller, more phenotypically homogeneous subgroups that can help to facilitate efforts to understand diverse ASD aetiology and inform design of future interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Diagnosis of Autism Spectrum Disorder According to Maternal-Race Ethnicity and Country of Birth: A Register-Based Study / Ifrah ABDULLAHI in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3611-3624 Titre : Diagnosis of Autism Spectrum Disorder According to Maternal-Race Ethnicity and Country of Birth: A Register-Based Study Type de document : Texte imprimé et/ou numérique Auteurs : Ifrah ABDULLAHI, Auteur ; K. WONG, Auteur ; Keely BEBBINGTON, Auteur ; R. MUTCH, Auteur ; N. DE KLERK, Auteur ; S. CHERIAN, Auteur ; J. DOWNS, Auteur ; H. LEONARD, Auteur ; E. J. GLASSON, Auteur Article en page(s) : p.3611-3624 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Immigrant  Intellectual disability  Severity  Symptomatology Index. décimale : PER Périodiques Résumé : An increased prevalence of autism spectrum disorder (ASD) among children of immigrant backgrounds has been observed but clinical profiles are rarely compared. Diagnostic data from children with ASD notified to the Western Australian Register for Autism Spectrum Disorders were analysed according to maternal-race ethnicity and country of birth. A total of 4776 children aged between 0 and 18 years diagnosed with ASD from 1999 to 2017 were included. Those born to immigrant mothers from lower income countries were younger at the time of diagnosis, had an increased risk of intellectual disability and poorer presentations in the social and communication domains. Further work is required to understand environmental influences that may affect children born to immigrant mothers and to improve monitoring and assessments. En ligne : http://dx.doi.org/10.1007/s10803-019-04068-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Diagnosis of Autism Spectrum Disorder According to Maternal-Race Ethnicity and Country of Birth: A Register-Based Study [Texte imprimé et/ou numérique] / Ifrah ABDULLAHI, Auteur ; K. WONG, Auteur ; Keely BEBBINGTON, Auteur ; R. MUTCH, Auteur ; N. DE KLERK, Auteur ; S. CHERIAN, Auteur ; J. DOWNS, Auteur ; H. LEONARD, Auteur ; E. J. GLASSON, Auteur . - p.3611-3624. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3611-3624 Mots-clés : Autism spectrum disorder  Immigrant  Intellectual disability  Severity  Symptomatology Index. décimale : PER Périodiques Résumé : An increased prevalence of autism spectrum disorder (ASD) among children of immigrant backgrounds has been observed but clinical profiles are rarely compared. Diagnostic data from children with ASD notified to the Western Australian Register for Autism Spectrum Disorders were analysed according to maternal-race ethnicity and country of birth. A total of 4776 children aged between 0 and 18 years diagnosed with ASD from 1999 to 2017 were included. Those born to immigrant mothers from lower income countries were younger at the time of diagnosis, had an increased risk of intellectual disability and poorer presentations in the social and communication domains. Further work is required to understand environmental influences that may affect children born to immigrant mothers and to improve monitoring and assessments. En ligne : http://dx.doi.org/10.1007/s10803-019-04068-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses / Andrew J. O. WHITEHOUSE in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.179-187 Titre : Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Gail A. ALVARES, Auteur ; Ashleigh LIN, Auteur ; John WRAY, Auteur ; Emma J. GLASSON, Auteur Article en page(s) : p.179-187 Langues : Anglais (eng) Mots-clés : autistic disorder  autism spectrum disorder  epidemiology  diagnosis  prevalence Index. décimale : PER Périodiques Résumé : The increasing prevalence of Autism Spectrum Disorders (ASD) may in part be due to a shift in the diagnostic threshold that has led to individuals with a less severe behavioral phenotype receiving a clinical diagnosis. This study examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder. Data were from a prospective register of new diagnoses in Western Australia (n?=?1252). From 2000 to 2006, we examined differences in both the percentage of newly diagnosed cases that met each criterion as well as severity ratings of the behaviors observed (not met, partially met, mild/moderate and extreme). Linear regression determined there was a statistically significant reduction from 2000 to 2006 in the percentage of new diagnoses meeting two of 12 criteria. There was also a reduction across the study period in the proportion of new cases rated as having extreme severity on six criteria. There was a reduction in the proportion of individuals with three or more criteria rated as extreme from 2000 (16.0%) to 2006 (1.6%), while percentage of new cases with no “extreme” rating on any criteria increased from 58.5% to 86.6% across the same period. This study provides the first clear evidence of a reduction over time in the behavioral severity of individuals diagnosed with Autistic Disorder during a period of stability in diagnostic criteria. A shift toward diagnosing individuals with less severe behavioral symptoms may have contributed to the increasing prevalence of Autistic Disorder diagnoses. En ligne : http://dx.doi.org/10.1002/aur.1740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Gail A. ALVARES, Auteur ; Ashleigh LIN, Auteur ; John WRAY, Auteur ; Emma J. GLASSON, Auteur . - p.179-187. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.179-187 Mots-clés : autistic disorder  autism spectrum disorder  epidemiology  diagnosis  prevalence Index. décimale : PER Périodiques Résumé : The increasing prevalence of Autism Spectrum Disorders (ASD) may in part be due to a shift in the diagnostic threshold that has led to individuals with a less severe behavioral phenotype receiving a clinical diagnosis. This study examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder. Data were from a prospective register of new diagnoses in Western Australia (n?=?1252). From 2000 to 2006, we examined differences in both the percentage of newly diagnosed cases that met each criterion as well as severity ratings of the behaviors observed (not met, partially met, mild/moderate and extreme). Linear regression determined there was a statistically significant reduction from 2000 to 2006 in the percentage of new diagnoses meeting two of 12 criteria. There was also a reduction across the study period in the proportion of new cases rated as having extreme severity on six criteria. There was a reduction in the proportion of individuals with three or more criteria rated as extreme from 2000 (16.0%) to 2006 (1.6%), while percentage of new cases with no “extreme” rating on any criteria increased from 58.5% to 86.6% across the same period. This study provides the first clear evidence of a reduction over time in the behavioral severity of individuals diagnosed with Autistic Disorder during a period of stability in diagnostic criteria. A shift toward diagnosing individuals with less severe behavioral symptoms may have contributed to the increasing prevalence of Autistic Disorder diagnoses. En ligne : http://dx.doi.org/10.1002/aur.1740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Investigating associations between birth order and autism diagnostic phenotypes / Gail A. ALVARES in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.961-970 Titre : Investigating associations between birth order and autism diagnostic phenotypes Type de document : Texte imprimé et/ou numérique Auteurs : Gail A. ALVARES, Auteur ; M. K. LICARI, Auteur ; P. G. STEVENSON, Auteur ; Keely BEBBINGTON, Auteur ; Matthew N. COOPER, Auteur ; E. J. GLASSON, Auteur ; D. W. TAN, Auteur ; M. ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.961-970 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Birth Order  Child, Preschool  Female  Humans  Male  Phenotype  Prospective Studies  Autism spectrum disorder  diagnosis  first birth  intellectual disability Index. décimale : PER Périodiques Résumé : BACKGROUND: Birth order effects have been linked to variability in intelligence, educational attainment and sexual orientation. First- and later-born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order. The present study investigated the potential association between birth order and ASD diagnostic phenotypes in a large and representative population sample. METHODS: Data were obtained from an ongoing prospective diagnostic registry, collected between 1999 and 2017, including children (1-18 years of age, n = 5,404) diagnosed with ASD in the state of Western Australia. Children with ASD were ranked relative to sibling's birth to establish birth order within families at time of ASD diagnosis. Information reported to the registry by health professionals at the time of diagnostic evaluation included demographic and family characteristics, functional abilities and intellectual capacity. RESULTS: Adaptive functioning and intelligence scores decreased with increasing birth order, with later-born children more likely to have an intellectual disability. Compared to first-born children with siblings, first-born children without siblings at the time of diagnosis also exhibited decreased cognitive functioning. CONCLUSIONS: These findings demonstrate for the first time an association between increasing birth order and variability in ASD clinical phenotypes at diagnosis, with potential evidence of reproductive curtailment in children without siblings. Taken together, these findings have significant implications for advancing understanding about the potential mechanisms that contribute to heterogeneity in ASD clinical presentations as a function of birth order and family size. En ligne : http://dx.doi.org/10.1111/jcpp.13349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Investigating associations between birth order and autism diagnostic phenotypes [Texte imprimé et/ou numérique] / Gail A. ALVARES, Auteur ; M. K. LICARI, Auteur ; P. G. STEVENSON, Auteur ; Keely BEBBINGTON, Auteur ; Matthew N. COOPER, Auteur ; E. J. GLASSON, Auteur ; D. W. TAN, Auteur ; M. ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.961-970. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.961-970 Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Birth Order  Child, Preschool  Female  Humans  Male  Phenotype  Prospective Studies  Autism spectrum disorder  diagnosis  first birth  intellectual disability Index. décimale : PER Périodiques Résumé : BACKGROUND: Birth order effects have been linked to variability in intelligence, educational attainment and sexual orientation. First- and later-born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order. The present study investigated the potential association between birth order and ASD diagnostic phenotypes in a large and representative population sample. METHODS: Data were obtained from an ongoing prospective diagnostic registry, collected between 1999 and 2017, including children (1-18 years of age, n = 5,404) diagnosed with ASD in the state of Western Australia. Children with ASD were ranked relative to sibling's birth to establish birth order within families at time of ASD diagnosis. Information reported to the registry by health professionals at the time of diagnostic evaluation included demographic and family characteristics, functional abilities and intellectual capacity. RESULTS: Adaptive functioning and intelligence scores decreased with increasing birth order, with later-born children more likely to have an intellectual disability. Compared to first-born children with siblings, first-born children without siblings at the time of diagnosis also exhibited decreased cognitive functioning. CONCLUSIONS: These findings demonstrate for the first time an association between increasing birth order and variability in ASD clinical phenotypes at diagnosis, with potential evidence of reproductive curtailment in children without siblings. Taken together, these findings have significant implications for advancing understanding about the potential mechanisms that contribute to heterogeneity in ASD clinical presentations as a function of birth order and family size. En ligne : http://dx.doi.org/10.1111/jcpp.13349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Prevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort / Melissa K. LICARI in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.298-306 Titre : Prevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort Type de document : Texte imprimé et/ou numérique Auteurs : Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Kandice J. VARCIN, Auteur ; Kiah EVANS, Auteur ; Dominique CLEARY, Auteur ; Siobhan L. REID, Auteur ; Emma J. GLASSON, Auteur ; Keely BEBBINGTON, Auteur ; Jess E. REYNOLDS, Auteur ; John WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.298-306 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental disabilities  motor disorders  motor skills  movement Index. décimale : PER Périodiques Résumé : Motor impairment is not currently included in the diagnostic criteria or evaluation of autism. This reflects the lack of large-scale studies demonstrating its prominence to advocate for change. We examined the prevalence of motor difficulties at the time of diagnosis in a large sample of children with autism utilizing standardized assessment, and the relationship between motor difficulties, core autism symptomology, and other prominent clinical features. Vineland Adaptive Behavior Scales were administered to children from the Western Australian Register for Autism Spectrum Disorders aged En ligne : http://dx.doi.org/10.1002/aur.2230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Prevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort [Texte imprimé et/ou numérique] / Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Kandice J. VARCIN, Auteur ; Kiah EVANS, Auteur ; Dominique CLEARY, Auteur ; Siobhan L. REID, Auteur ; Emma J. GLASSON, Auteur ; Keely BEBBINGTON, Auteur ; Jess E. REYNOLDS, Auteur ; John WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.298-306. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.298-306 Mots-clés : autism spectrum disorder  developmental disabilities  motor disorders  motor skills  movement Index. décimale : PER Périodiques Résumé : Motor impairment is not currently included in the diagnostic criteria or evaluation of autism. This reflects the lack of large-scale studies demonstrating its prominence to advocate for change. We examined the prevalence of motor difficulties at the time of diagnosis in a large sample of children with autism utilizing standardized assessment, and the relationship between motor difficulties, core autism symptomology, and other prominent clinical features. Vineland Adaptive Behavior Scales were administered to children from the Western Australian Register for Autism Spectrum Disorders aged En ligne : http://dx.doi.org/10.1002/aur.2230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

The misnomer of 'high functioning autism': Intelligence is an imprecise predictor of functional abilities at diagnosis / Gail A. ALVARES in Autism, 24-1 (January 2020)  

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