Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function / Eleni A. DEMETRIOU in Autism, 25-8 (November 2021)  

Public ISBD [article]  inAutism > 25-8 (November 2021) . - p.2223-2237 Titre : Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function Type de document : texte imprimé Auteurs : Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; S. H. PARK, Auteur ; L. PELLICANO, Auteur ; Y. J. C. SONG, Auteur ; S. L. NAISMITH, Auteur ; I. B. HICKIE, Auteur ; E. E. THOMAS, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : p.2223-2237 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Cognition  Executive Function  Female  Humans  Male  Neuropsychological Tests  Self Report  Sex Characteristics  Behavioural Rating Inventory of Executive Function  Cambridge Neuropsychological Test Automated Battery  autism spectrum disorder  executive function  sex differences Index. décimale : PER Périodiques Résumé : Research comparing females and males with a diagnosis of autism suggests that there are sex differences in some characteristics such as behaviour regulation. One area not studied in detail is whether females and males with autism perform differently in tests of cognitive ability. The results of previous research are quite mixed. One explanation may be that some research comparing females and males with autism did not include a neurotypical control group for comparison. As a result, it is not clear whether the sex differences in cognitive ability observed in people with autism are similar to differences between neurotypical males and females. To better understand whether there are unique differences between males and females with autism, it is important to also compare them with neurotypical males and females. In our research, we included a neurotypical group and compared males and females with and without a diagnosis of autism. We found that the sex differences in autism are similar to what we observe in males and females without autism. Our study showed that compared with males, females (with and without autism) do better in assessments of processing speed, cognitive flexibility, verbal learning and memory and semantic fluency. Our results suggest that although females show different cognitive performance to males, these sex differences were not specific to the group with a diagnosis of autism. En ligne : http://dx.doi.org/10.1177/13623613211014991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function [texte imprimé] / Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; S. H. PARK, Auteur ; L. PELLICANO, Auteur ; Y. J. C. SONG, Auteur ; S. L. NAISMITH, Auteur ; I. B. HICKIE, Auteur ; E. E. THOMAS, Auteur ; A. J. GUASTELLA, Auteur . - p.2223-2237. Langues : Anglais (eng) in Autism > 25-8 (November 2021) . - p.2223-2237 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Cognition  Executive Function  Female  Humans  Male  Neuropsychological Tests  Self Report  Sex Characteristics  Behavioural Rating Inventory of Executive Function  Cambridge Neuropsychological Test Automated Battery  autism spectrum disorder  executive function  sex differences Index. décimale : PER Périodiques Résumé : Research comparing females and males with a diagnosis of autism suggests that there are sex differences in some characteristics such as behaviour regulation. One area not studied in detail is whether females and males with autism perform differently in tests of cognitive ability. The results of previous research are quite mixed. One explanation may be that some research comparing females and males with autism did not include a neurotypical control group for comparison. As a result, it is not clear whether the sex differences in cognitive ability observed in people with autism are similar to differences between neurotypical males and females. To better understand whether there are unique differences between males and females with autism, it is important to also compare them with neurotypical males and females. In our research, we included a neurotypical group and compared males and females with and without a diagnosis of autism. We found that the sex differences in autism are similar to what we observe in males and females without autism. Our study showed that compared with males, females (with and without autism) do better in assessments of processing speed, cognitive flexibility, verbal learning and memory and semantic fluency. Our results suggest that although females show different cognitive performance to males, these sex differences were not specific to the group with a diagnosis of autism. En ligne : http://dx.doi.org/10.1177/13623613211014991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder / A. MASI in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 63p. Titre : Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder Type de document : texte imprimé Auteurs : A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : 63p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Behavior  Cytokine  Pediatric  Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder [texte imprimé] / A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur . - 63p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 63p. Mots-clés : Autism spectrum disorder  Behavior  Cytokine  Pediatric  Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress / S. H. PARK in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1675-1686 Titre : Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress Type de document : texte imprimé Auteurs : S. H. PARK, Auteur ; Y. J. C. SONG, Auteur ; Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; A. NORTON, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; D. F. HERMENS, Auteur ; N. GLOZIER, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : p.1675-1686 Langues : Anglais (eng) Mots-clés : developmental disorders  distress  health services  mental health  treatment  well being Index. décimale : PER Périodiques Résumé : In this study, we consecutively recruited treatment-seeking young autistic adults without intellectual impairment aged 16-30 years who presented to a mental health service and evaluated general health (distress, quality of life, and disability), functioning (work loss days and social functioning), and mood symptoms (depression, anxiety, and stress) in those diagnosed with autism spectrum disorder (n = 96). This group was compared to young adults presenting to the same service with primary mental health disorders (depression, n = 343; bipolar, n = 132; psychosis, n = 166; and anxiety, n = 303). This study also investigated the influence of mood symptoms on general health and functioning in the autism spectrum disorder group. Young autistic adults reported significant general health and functioning impairments that were of similar degree to those presenting with primary mental health disorders. Interestingly, the autistic group also reported similarly high levels of mood symptoms to those with primary depressive and anxiety disorders. In the autistic group, depressive symptoms were strongly associated with distress, quality of life, and work loss days, while stress symptoms were strongly associated with disability. This study highlights further research, and mental health services are required specifically targeting young autistic adults to address their significant unmet needs. En ligne : http://dx.doi.org/10.1177/1362361318823925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress [texte imprimé] / S. H. PARK, Auteur ; Y. J. C. SONG, Auteur ; Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; A. NORTON, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; D. F. HERMENS, Auteur ; N. GLOZIER, Auteur ; A. J. GUASTELLA, Auteur . - p.1675-1686. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1675-1686 Mots-clés : developmental disorders  distress  health services  mental health  treatment  well being Index. décimale : PER Périodiques Résumé : In this study, we consecutively recruited treatment-seeking young autistic adults without intellectual impairment aged 16-30 years who presented to a mental health service and evaluated general health (distress, quality of life, and disability), functioning (work loss days and social functioning), and mood symptoms (depression, anxiety, and stress) in those diagnosed with autism spectrum disorder (n = 96). This group was compared to young adults presenting to the same service with primary mental health disorders (depression, n = 343; bipolar, n = 132; psychosis, n = 166; and anxiety, n = 303). This study also investigated the influence of mood symptoms on general health and functioning in the autism spectrum disorder group. Young autistic adults reported significant general health and functioning impairments that were of similar degree to those presenting with primary mental health disorders. Interestingly, the autistic group also reported similarly high levels of mood symptoms to those with primary depressive and anxiety disorders. In the autistic group, depressive symptoms were strongly associated with distress, quality of life, and work loss days, while stress symptoms were strongly associated with disability. This study highlights further research, and mental health services are required specifically targeting young autistic adults to address their significant unmet needs. En ligne : http://dx.doi.org/10.1177/1362361318823925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? / A. J. GUASTELLA in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1323-1332 Titre : Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? Type de document : texte imprimé Auteurs : A. J. GUASTELLA, Auteur ; Matthew N. COOPER, Auteur ; C. R. H. WHITE, Auteur ; M. K. WHITE, Auteur ; C. E. PENNELL, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1323-1332 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  behaviour problems  developmental psychopathology  empathy  public health Index. décimale : PER Périodiques Résumé : BACKGROUND: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. METHODS: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring. The Child Behaviour Checklist was used to measure offspring behavioural difficulties at ages 5, 8, 10, 14 and 17 years. Autism spectrum disorder was formally diagnosed by consensus of a team of specialists. At 20 years, offspring completed a measure of autistic-like traits, the Autism Spectrum Quotient (AQ). Oxytocin exposure prior to birth was analysed using categorical and continuous approaches (maternal oxytocin dose) with univariate and multivariate statistical techniques. RESULTS: Categorical analyses of oxytocin exposure prior to birth demonstrated no group differences in any measures of child behaviour. A small in magnitude dose-response association was observed for clinically significant total behaviour symptoms (adjusted odds ratio 1.03; 95% CI: 1.01-1.06, p < .01). Exogenous oxytocin administration prior to birth was not associated with ASD (OR: 0.64; 95% CI: 0.15-2.12, p = .46) or high levels of autistic-like traits (p = .93), as assessed by the AQ. CONCLUSIONS: This study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour. The results do not provide evidence to support the theory that exogenous OT has a clinically significant negative impact on the long-term mental health of children. En ligne : http://dx.doi.org/10.1111/jcpp.12924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? [texte imprimé] / A. J. GUASTELLA, Auteur ; Matthew N. COOPER, Auteur ; C. R. H. WHITE, Auteur ; M. K. WHITE, Auteur ; C. E. PENNELL, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1323-1332. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1323-1332 Mots-clés : Autism spectrum disorders  behaviour problems  developmental psychopathology  empathy  public health Index. décimale : PER Périodiques Résumé : BACKGROUND: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. METHODS: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring. The Child Behaviour Checklist was used to measure offspring behavioural difficulties at ages 5, 8, 10, 14 and 17 years. Autism spectrum disorder was formally diagnosed by consensus of a team of specialists. At 20 years, offspring completed a measure of autistic-like traits, the Autism Spectrum Quotient (AQ). Oxytocin exposure prior to birth was analysed using categorical and continuous approaches (maternal oxytocin dose) with univariate and multivariate statistical techniques. RESULTS: Categorical analyses of oxytocin exposure prior to birth demonstrated no group differences in any measures of child behaviour. A small in magnitude dose-response association was observed for clinically significant total behaviour symptoms (adjusted odds ratio 1.03; 95% CI: 1.01-1.06, p < .01). Exogenous oxytocin administration prior to birth was not associated with ASD (OR: 0.64; 95% CI: 0.15-2.12, p = .46) or high levels of autistic-like traits (p = .93), as assessed by the AQ. CONCLUSIONS: This study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour. The results do not provide evidence to support the theory that exogenous OT has a clinically significant negative impact on the long-term mental health of children. En ligne : http://dx.doi.org/10.1111/jcpp.12924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Executive Function and Social Cognition Performance Predicts Social Difficulty for Autistic Adults / T. R. WONG in Autism Research, 18-9 (September 2025)  

Public ISBD [article]  inAutism Research > 18-9 (September 2025) . - p.1734-1745 Titre : Executive Function and Social Cognition Performance Predicts Social Difficulty for Autistic Adults Type de document : texte imprimé Auteurs : T. R. WONG, Auteur ; Kelsie A. BOULTON, Auteur ; E. A. DEMETRIOU, Auteur ; E. E. THOMAS, Auteur ; N. L. PHILLIPS, Auteur ; L. HANKIN, Auteur ; S. H. PARK, Auteur ; I. B. HICKIE, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : p.1734-1745 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT There has been limited research aimed at understanding the cognitive features that predict outcomes in autistic adults. Difficulties in social cognition and executive function (EF) processes have been proposed as important cognitive components underlying social functioning outcomes. In this study, 305 autistic adults were administered a battery of social cognition, EF, and social functioning assessments to determine the degree to which social cognition and EF factors predicted outcomes. For social cognition, hierarchical regressions showed that EF explained neither theory of mind scores nor emotion recognition scores. We then ran several mediation models to determine whether EF explained social functioning independently of social cognition. These exploratory analyses show that poorer performance-based EF and social cognition both predicted more clinician-observed social challenges, while poorer self-reported EF and social cognition predicted more self-reported social challenges. Effects on outcomes were independent of each other. Our results highlight the potential of bot EF and social cognition measures to provide clinically meaningful markers for social functioning, but via separate pathways. This study supports the utility of targeting EF and social cognition processes in autistic adults in assessment and support pathways. En ligne : https://doi.org/10.1002/aur.70090 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Executive Function and Social Cognition Performance Predicts Social Difficulty for Autistic Adults [texte imprimé] / T. R. WONG, Auteur ; Kelsie A. BOULTON, Auteur ; E. A. DEMETRIOU, Auteur ; E. E. THOMAS, Auteur ; N. L. PHILLIPS, Auteur ; L. HANKIN, Auteur ; S. H. PARK, Auteur ; I. B. HICKIE, Auteur ; A. J. GUASTELLA, Auteur . - p.1734-1745. Langues : Anglais (eng) in Autism Research > 18-9 (September 2025) . - p.1734-1745 Index. décimale : PER Périodiques Résumé : ABSTRACT There has been limited research aimed at understanding the cognitive features that predict outcomes in autistic adults. Difficulties in social cognition and executive function (EF) processes have been proposed as important cognitive components underlying social functioning outcomes. In this study, 305 autistic adults were administered a battery of social cognition, EF, and social functioning assessments to determine the degree to which social cognition and EF factors predicted outcomes. For social cognition, hierarchical regressions showed that EF explained neither theory of mind scores nor emotion recognition scores. We then ran several mediation models to determine whether EF explained social functioning independently of social cognition. These exploratory analyses show that poorer performance-based EF and social cognition both predicted more clinician-observed social challenges, while poorer self-reported EF and social cognition predicted more self-reported social challenges. Effects on outcomes were independent of each other. Our results highlight the potential of bot EF and social cognition measures to provide clinically meaningful markers for social functioning, but via separate pathways. This study supports the utility of targeting EF and social cognition processes in autistic adults in assessment and support pathways. En ligne : https://doi.org/10.1002/aur.70090 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Perceptions of social and work functioning are related to social anxiety and executive function in autistic adults / A. WOOLARD in Autism, 25-7 (October 2021)  

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Predictors of adaptive functioning in preschool aged children with autism spectrum disorder / M. A. HODGE in Autism Research, 14-7 (July 2021)  

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Reduced heart rate variability in adults with autism spectrum disorder / R. THAPA in Autism Research, 12-6 (June 2019)  

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Replication of the psychometric properties of the WHODAS-II in individuals with autism spectrum disorder / S. H. PARK in Autism Research, 12-12 (December)  

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Social anxiety symptoms in autism spectrum disorder and social anxiety disorder: Considering the reliability of self-report instruments in adult cohorts / Kelsie A. BOULTON in Autism Research, 14-11 (November 2021)  

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The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder / Marilena M. DEMAYO in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

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Validation of the 36-item and 12-item self-report World Health Organization Disability Assessment Schedule II (WHODAS-II) in individuals with autism spectrum disorder / S. H. PARK in Autism Research, 12-7 (July 2019)  

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