Association between CNTNAP2 polymorphisms and autism: A family-based study in the chinese han population and a meta-analysis combined with GWAS data of psychiatric genomics consortium / T. ZHANG in Autism Research, 12-4 (April 2019)  

Public ISBD [article]  inAutism Research > 12-4 (April 2019) . - p.553-561 Titre : Association between CNTNAP2 polymorphisms and autism: A family-based study in the chinese han population and a meta-analysis combined with GWAS data of psychiatric genomics consortium Type de document : Texte imprimé et/ou numérique Auteurs : T. ZHANG, Auteur ; J. ZHANG, Auteur ; Z. WANG, Auteur ; M. JIA, Auteur ; T. LU, Auteur ; H. WANG, Auteur ; W. YUE, Auteur ; D. ZHANG, Auteur ; J. LI, Auteur ; L. WANG, Auteur Article en page(s) : p.553-561 Langues : Anglais (eng) Mots-clés : Cntnap2  Pgc  autism  meta-analysis  polymorphism Index. décimale : PER Périodiques Résumé : Autism is a childhood neuropsychiatric disorder with evidence of a strong genetic component in the complex etiologies. Contactin-associated protein-like 2 (CNTNAP2), a member of the neurexin superfamily, plays an essential role in neural development. CNTNAP2 was considered as one of the most susceptible genes for autism spectrum disorder (ASD). Some studies indicated the association of CNTNAP2 with ASD, while others reported no association. Given the inconsistent results of the previous studies, we performed a family-based association study between 9 single-nucleotide polymorphisms (SNPs) of CNTNAP2 and autism in 640 autistic trios in the Chinese Han population. Then, an updated meta-analysis, combined with the data from Psychiatric Genomics Consortium (iPSYCH-PGC ASD, 2017) and available association studies, was conducted. No SNPs were significantly associated with autism in the Chinese Han population. In the meta-analysis, the two frequently reported SNPs (rs2710102 and rs7794745) showed no significant association with ASD. Therefore, CNTNAP2 polymorphisms might not be associated with autism. Autism Research 2019, 12: 553-561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In present family-based association study, no single-nucleotide polymorphisms (SNPs) were significantly associated with autism in the Chinese Han population. In the updated meta-analysis, the association between the two frequently reported SNPs (rs2710102 and rs7794745) in CNTNAP2 and the risk of ASD was explored. However, the results showed no significant association. Therefore, our study suggested that CNTNAP2 polymorphisms might not be associated with autism. En ligne : https://dx.doi.org/10.1002/aur.2078 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Association between CNTNAP2 polymorphisms and autism: A family-based study in the chinese han population and a meta-analysis combined with GWAS data of psychiatric genomics consortium [Texte imprimé et/ou numérique] / T. ZHANG, Auteur ; J. ZHANG, Auteur ; Z. WANG, Auteur ; M. JIA, Auteur ; T. LU, Auteur ; H. WANG, Auteur ; W. YUE, Auteur ; D. ZHANG, Auteur ; J. LI, Auteur ; L. WANG, Auteur . - p.553-561. Langues : Anglais (eng) in Autism Research > 12-4 (April 2019) . - p.553-561 Mots-clés : Cntnap2  Pgc  autism  meta-analysis  polymorphism Index. décimale : PER Périodiques Résumé : Autism is a childhood neuropsychiatric disorder with evidence of a strong genetic component in the complex etiologies. Contactin-associated protein-like 2 (CNTNAP2), a member of the neurexin superfamily, plays an essential role in neural development. CNTNAP2 was considered as one of the most susceptible genes for autism spectrum disorder (ASD). Some studies indicated the association of CNTNAP2 with ASD, while others reported no association. Given the inconsistent results of the previous studies, we performed a family-based association study between 9 single-nucleotide polymorphisms (SNPs) of CNTNAP2 and autism in 640 autistic trios in the Chinese Han population. Then, an updated meta-analysis, combined with the data from Psychiatric Genomics Consortium (iPSYCH-PGC ASD, 2017) and available association studies, was conducted. No SNPs were significantly associated with autism in the Chinese Han population. In the meta-analysis, the two frequently reported SNPs (rs2710102 and rs7794745) showed no significant association with ASD. Therefore, CNTNAP2 polymorphisms might not be associated with autism. Autism Research 2019, 12: 553-561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In present family-based association study, no single-nucleotide polymorphisms (SNPs) were significantly associated with autism in the Chinese Han population. In the updated meta-analysis, the association between the two frequently reported SNPs (rs2710102 and rs7794745) in CNTNAP2 and the risk of ASD was explored. However, the results showed no significant association. Therefore, our study suggested that CNTNAP2 polymorphisms might not be associated with autism. En ligne : https://dx.doi.org/10.1002/aur.2078 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Brief Report: Identifying Concerns of Military Caregivers with Children Diagnosed with ASD Following a Military Directed Relocation / B. E. FARLEY in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.447-453 Titre : Brief Report: Identifying Concerns of Military Caregivers with Children Diagnosed with ASD Following a Military Directed Relocation Type de document : Texte imprimé et/ou numérique Auteurs : B. E. FARLEY, Auteur ; A. GRIFFITH, Auteur ; A. MAHONEY, Auteur ; D. ZHANG, Auteur ; L. KRUSE, Auteur Article en page(s) : p.447-453 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Caregivers  Child  Humans  Military Personnel  Referral and Consultation  Surveys and Questionnaires  Autism  Barriers  Military  Relocation Index. décimale : PER Périodiques Résumé : Military families relocate three times more often than non-military families. Those whom have children diagnosed with Autism Spectrum Disorder face challenges related to inconsistencies in services, delay of services, and lack of continuity of care. The current study expands the limited research examining the experiences of military families with children with Autism by focusing on impact of relocation, specifically identifying potential causes of delays in services. An online survey of 25 military caregivers of children with autism suggests potential delays in service related to provider waitlists, obtaining new referrals, and lengthy intake processes. The impact of these inconsistencies is discussed in relation to child progress and the need for future research in this area. En ligne : http://dx.doi.org/10.1007/s10803-021-04936-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Brief Report: Identifying Concerns of Military Caregivers with Children Diagnosed with ASD Following a Military Directed Relocation [Texte imprimé et/ou numérique] / B. E. FARLEY, Auteur ; A. GRIFFITH, Auteur ; A. MAHONEY, Auteur ; D. ZHANG, Auteur ; L. KRUSE, Auteur . - p.447-453. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.447-453 Mots-clés : Autism Spectrum Disorder/diagnosis  Caregivers  Child  Humans  Military Personnel  Referral and Consultation  Surveys and Questionnaires  Autism  Barriers  Military  Relocation Index. décimale : PER Périodiques Résumé : Military families relocate three times more often than non-military families. Those whom have children diagnosed with Autism Spectrum Disorder face challenges related to inconsistencies in services, delay of services, and lack of continuity of care. The current study expands the limited research examining the experiences of military families with children with Autism by focusing on impact of relocation, specifically identifying potential causes of delays in services. An online survey of 25 military caregivers of children with autism suggests potential delays in service related to provider waitlists, obtaining new referrals, and lengthy intake processes. The impact of these inconsistencies is discussed in relation to child progress and the need for future research in this area. En ligne : http://dx.doi.org/10.1007/s10803-021-04936-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong / R. Y. F. HO in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4147-4159 Titre : Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong Type de document : Texte imprimé et/ou numérique Auteurs : R. Y. F. HO, Auteur ; D. ZHANG, Auteur ; S. K. C. CHAN, Auteur ; T. T. GAO, Auteur ; E. K. P. LEE, Auteur ; H. H. M. LO, Auteur ; P. AU YEUNG, Auteur ; Kelly Y. C. LAI, Auteur ; Susan M. BOGELS, Auteur ; E. I. DE BRUIN, Auteur ; S. Y. S. WONG, Auteur Article en page(s) : p.4147-4159 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/therapy  China  Hong Kong  Humans  Mindfulness  Parenting  Parents  Autism spectrum disorder  Effectiveness  Feasibility  MYmind Index. décimale : PER Périodiques Résumé : This study investigated the feasibility and preliminary effectiveness of a concurrent mindfulness program (MYmind) on Chinese adolescents with autism spectrum disorder and their parents in Hong Kong, China using a randomized controlled trial with a waitlist control group. Results showed the study had 80% compliance rate, 0% dropout rate, and 89% response rate. Between-group comparisons showed mindfulness had trend effects on parent's rumination (g?=?1.16), mindful parenting (d?=?0.6), parenting style (d?=?0.59), and parenting stress (d?=?0.5). The study demonstrated the feasibility of the MYmind program in the Chinese context. A larger trial with longer follow-up period is suggested to better examine the effect of mindfulness on adolescents with ASD and their parents. En ligne : http://dx.doi.org/10.1007/s10803-020-04729-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong [Texte imprimé et/ou numérique] / R. Y. F. HO, Auteur ; D. ZHANG, Auteur ; S. K. C. CHAN, Auteur ; T. T. GAO, Auteur ; E. K. P. LEE, Auteur ; H. H. M. LO, Auteur ; P. AU YEUNG, Auteur ; Kelly Y. C. LAI, Auteur ; Susan M. BOGELS, Auteur ; E. I. DE BRUIN, Auteur ; S. Y. S. WONG, Auteur . - p.4147-4159. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4147-4159 Mots-clés : Adolescent  Autism Spectrum Disorder/therapy  China  Hong Kong  Humans  Mindfulness  Parenting  Parents  Autism spectrum disorder  Effectiveness  Feasibility  MYmind Index. décimale : PER Périodiques Résumé : This study investigated the feasibility and preliminary effectiveness of a concurrent mindfulness program (MYmind) on Chinese adolescents with autism spectrum disorder and their parents in Hong Kong, China using a randomized controlled trial with a waitlist control group. Results showed the study had 80% compliance rate, 0% dropout rate, and 89% response rate. Between-group comparisons showed mindfulness had trend effects on parent's rumination (g?=?1.16), mindful parenting (d?=?0.6), parenting style (d?=?0.59), and parenting stress (d?=?0.5). The study demonstrated the feasibility of the MYmind program in the Chinese context. A larger trial with longer follow-up period is suggested to better examine the effect of mindfulness on adolescents with ASD and their parents. En ligne : http://dx.doi.org/10.1007/s10803-020-04729-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Identifying Atypical Development: A Role of Day-Care Workers? / D. ZHANG in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3685-3694 Titre : Identifying Atypical Development: A Role of Day-Care Workers? Type de document : Texte imprimé et/ou numérique Auteurs : D. ZHANG, Auteur ; I. KRIEBER-TOMANTSCHGER, Auteur ; L. POUSTKA, Auteur ; H. ROEYERS, Auteur ; J. SIGAFOOS, Auteur ; Sven BÖLTE, Auteur ; P. B. MARSCHIK, Auteur ; C. EINSPIELER, Auteur Article en page(s) : p.3685-3694 Langues : Anglais (eng) Mots-clés : Day-care workers  Developmental disability  Early identification  Fragile X syndrome  Retrospective video analysis Index. décimale : PER Périodiques Résumé : Identifying the early signs of developmental disability is important for ensuring timely diagnosis and early intervention. Day-care workers may be in a prime position to notice potential developmental deviations, but it is unclear if they can accurately recognize subtle early signs of atypical development. Sixty day-care workers examined home-videos of very young children with fragile X syndrome and typically developing children. Results indicated that most day-care workers can distinguish typical and atypical development in general and might therefore have an important role in early identification. Special work experience and advanced pedagogical training appeared to boost day-care workers' sensitivity to detect atypical features in early development and to provide effective daily surveillance. En ligne : http://dx.doi.org/10.1007/s10803-019-04056-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Identifying Atypical Development: A Role of Day-Care Workers? [Texte imprimé et/ou numérique] / D. ZHANG, Auteur ; I. KRIEBER-TOMANTSCHGER, Auteur ; L. POUSTKA, Auteur ; H. ROEYERS, Auteur ; J. SIGAFOOS, Auteur ; Sven BÖLTE, Auteur ; P. B. MARSCHIK, Auteur ; C. EINSPIELER, Auteur . - p.3685-3694. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3685-3694 Mots-clés : Day-care workers  Developmental disability  Early identification  Fragile X syndrome  Retrospective video analysis Index. décimale : PER Périodiques Résumé : Identifying the early signs of developmental disability is important for ensuring timely diagnosis and early intervention. Day-care workers may be in a prime position to notice potential developmental deviations, but it is unclear if they can accurately recognize subtle early signs of atypical development. Sixty day-care workers examined home-videos of very young children with fragile X syndrome and typically developing children. Results indicated that most day-care workers can distinguish typical and atypical development in general and might therefore have an important role in early identification. Special work experience and advanced pedagogical training appeared to boost day-care workers' sensitivity to detect atypical features in early development and to provide effective daily surveillance. En ligne : http://dx.doi.org/10.1007/s10803-019-04056-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

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