Exploring sensory phenotypes in autism spectrum disorder / N. E. SCHEERER in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 67 p. Titre : Exploring sensory phenotypes in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : N. E. SCHEERER, Auteur ; K. CURCIN, Auteur ; B. STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; E. KELLEY, Auteur ; S. GEORGIADES, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : ADHD traits  Adaptive behaviour  Autism spectrum disorder  Cluster analysis  OCD traits  Restrictive and repetitive behaviours  Sensory phenotypes  Sensory processing  Social communication  have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical reactions to the sensory environment are often reported in autistic individuals, with a high degree of variability across the sensory modalities. These sensory differences have been shown to promote challenging behaviours and distress in autistic individuals and are predictive of other functions including motor, social, and cognitive abilities. Preliminary research suggests that specific sensory differences may cluster together within individuals creating discrete sensory phenotypes. However, the manner in which these sensory differences cluster, and whether the resulting phenotypes are associated with specific cognitive and social challenges is unclear. METHODS: Short sensory profile data from 599 autistic children and adults between the ages of 1 and 21 years were subjected to a K-means cluster analysis. Analysis of variances compared age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder across the resultant clusters. RESULTS: A five-cluster model was found to minimize error variance and produce five sensory phenotypes: (1) sensory adaptive, (2) generalized sensory differences, (3) taste and smell sensitivity, (4) under-responsive and sensation seeking, and (5) movement difficulties with low energy. Age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder were found to differ significantly across the five phenotypes. LIMITATIONS: The results were based on parent-report measures of sensory processing, adaptive behaviour, traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder, which may limit the generalizability of the findings. Further, not all measures are standardized, or psychometrically validated with an autism population. Autistic individuals with an intellectual disability were underrepresented in this sample. Further, as these data were obtained from established records from a large provincial database, not all measures were completed for all individuals. CONCLUSIONS: These findings suggest that sensory difficulties in autistic individuals can be clustered into sensory phenotypes, and that these phenotypes are associated with behavioural differences. Given the large degree of heterogeneity in sensory difficulties seen in the autistic population, these sensory phenotypes represent an effective way to parse that heterogeneity and create phenotypes that may aid in the development of effective treatments and interventions for sensory difficulties. En ligne : http://dx.doi.org/10.1186/s13229-021-00471-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Exploring sensory phenotypes in autism spectrum disorder [Texte imprimé et/ou numérique] / N. E. SCHEERER, Auteur ; K. CURCIN, Auteur ; B. STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; E. KELLEY, Auteur ; S. GEORGIADES, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 67 p. Mots-clés : ADHD traits  Adaptive behaviour  Autism spectrum disorder  Cluster analysis  OCD traits  Restrictive and repetitive behaviours  Sensory phenotypes  Sensory processing  Social communication  have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical reactions to the sensory environment are often reported in autistic individuals, with a high degree of variability across the sensory modalities. These sensory differences have been shown to promote challenging behaviours and distress in autistic individuals and are predictive of other functions including motor, social, and cognitive abilities. Preliminary research suggests that specific sensory differences may cluster together within individuals creating discrete sensory phenotypes. However, the manner in which these sensory differences cluster, and whether the resulting phenotypes are associated with specific cognitive and social challenges is unclear. METHODS: Short sensory profile data from 599 autistic children and adults between the ages of 1 and 21 years were subjected to a K-means cluster analysis. Analysis of variances compared age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder across the resultant clusters. RESULTS: A five-cluster model was found to minimize error variance and produce five sensory phenotypes: (1) sensory adaptive, (2) generalized sensory differences, (3) taste and smell sensitivity, (4) under-responsive and sensation seeking, and (5) movement difficulties with low energy. Age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder were found to differ significantly across the five phenotypes. LIMITATIONS: The results were based on parent-report measures of sensory processing, adaptive behaviour, traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder, which may limit the generalizability of the findings. Further, not all measures are standardized, or psychometrically validated with an autism population. Autistic individuals with an intellectual disability were underrepresented in this sample. Further, as these data were obtained from established records from a large provincial database, not all measures were completed for all individuals. CONCLUSIONS: These findings suggest that sensory difficulties in autistic individuals can be clustered into sensory phenotypes, and that these phenotypes are associated with behavioural differences. Given the large degree of heterogeneity in sensory difficulties seen in the autistic population, these sensory phenotypes represent an effective way to parse that heterogeneity and create phenotypes that may aid in the development of effective treatments and interventions for sensory difficulties. En ligne : http://dx.doi.org/10.1186/s13229-021-00471-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder / N. J. BRIERLEY in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3391-3400 Titre : Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : N. J. BRIERLEY, Auteur ; C. G. MCDONNELL, Auteur ; K. M. A. PARKS, Auteur ; S. E. SCHULZ, Auteur ; T. C. DALAL, Auteur ; E. KELLEY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; J. CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : p.3391-3400 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/diagnosis/epidemiology  Autism Spectrum Disorder/diagnosis  Child  Female  Humans  Stereotyped Behavior  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Factor analysis  Restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Restricted interests and repetitive behaviors (RRBs) are core symptoms of autism spectrum disorder (ASD), and commonly occur in attention-deficit/hyperactivity disorder (ADHD). Little is known about how RRBs manifest in ADHD. We quantified and compared factor structures of RRBs in children with ASD (n?=?634) or ADHD (n?=?448), and related factors to sex and IQ. A four-factor solution emerged, including Stereotypy, Self-Injury, Compulsions, and Ritualistic/Sameness. Factor structures were equivalent across diagnoses, though symptoms were more severe in ASD. IQ negatively correlated with Stereotypy, Self-Injury, and Compulsions in ASD, and negatively correlated with Compulsions and Ritualistic/Sameness behaviors in ADHD. In ASD only, females exhibited higher Self-Injury. Thus, patterns of RRBs are preserved across ASD and ADHD, but severity and relationship with IQ differed. En ligne : http://dx.doi.org/10.1007/s10803-020-04800-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder [Texte imprimé et/ou numérique] / N. J. BRIERLEY, Auteur ; C. G. MCDONNELL, Auteur ; K. M. A. PARKS, Auteur ; S. E. SCHULZ, Auteur ; T. C. DALAL, Auteur ; E. KELLEY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; J. CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur . - p.3391-3400. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3391-3400 Mots-clés : Attention Deficit Disorder with Hyperactivity/diagnosis/epidemiology  Autism Spectrum Disorder/diagnosis  Child  Female  Humans  Stereotyped Behavior  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Factor analysis  Restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Restricted interests and repetitive behaviors (RRBs) are core symptoms of autism spectrum disorder (ASD), and commonly occur in attention-deficit/hyperactivity disorder (ADHD). Little is known about how RRBs manifest in ADHD. We quantified and compared factor structures of RRBs in children with ASD (n?=?634) or ADHD (n?=?448), and related factors to sex and IQ. A four-factor solution emerged, including Stereotypy, Self-Injury, Compulsions, and Ritualistic/Sameness. Factor structures were equivalent across diagnoses, though symptoms were more severe in ASD. IQ negatively correlated with Stereotypy, Self-Injury, and Compulsions in ASD, and negatively correlated with Compulsions and Ritualistic/Sameness behaviors in ADHD. In ASD only, females exhibited higher Self-Injury. Thus, patterns of RRBs are preserved across ASD and ADHD, but severity and relationship with IQ differed. En ligne : http://dx.doi.org/10.1007/s10803-020-04800-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression / X. LIU in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539 Titre : Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression Type de document : Texte imprimé et/ou numérique Auteurs : X. LIU, Auteur ; M. ZOU, Auteur ; C. SUN, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur Article en page(s) : p.522-539 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology  Diet  Dietary Supplements  Female  Folic Acid  Humans  Pregnancy  Vitamins  Autism spectrum disorder  Folic acid  Meta-analysis  Meta-regression  Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 ?g folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression [Texte imprimé et/ou numérique] / X. LIU, Auteur ; M. ZOU, Auteur ; C. SUN, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur . - p.522-539. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539 Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology  Diet  Dietary Supplements  Female  Folic Acid  Humans  Pregnancy  Vitamins  Autism spectrum disorder  Folic acid  Meta-analysis  Meta-regression  Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 ?g folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis / X. LIU in Autism, 26-1 (January 2022)  

Public ISBD [article]  inAutism > 26-1 (January 2022) . - p.33-50 Titre : Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : X. LIU, Auteur ; X. SUN, Auteur ; C. SUN, Auteur ; M. ZOU, Auteur ; Y. CHEN, Auteur ; J. HUANG, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur Article en page(s) : p.33-50 Langues : Anglais (eng) Mots-clés : adulthood  autism spectrum disorder (ASD)  childhood  co-occurrence  epilepsy  meta-analyses Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence. A total of 66 studies from 53 articles were included in this study. The results showed that epilepsy is more common in autistic individuals than in the general population. The prevalence of epilepsy in autistic individuals in the clinical sample-based studies was higher than that in the population-based based cross-sectional or cohort studies. The prevalence of epilepsy in autistic adults was higher than that in autistic children. A significantly increased prevalence of epilepsy was detected in the autistic adolescent group (11-17?years old), and a higher trend of prevalence of epilepsy was observed in the autistic pre-school group (??6?-years-old) than that of the autistic school-aged group (7-10?years-old). The prevalence of epilepsy increased with age, female rate, and low intellectual function rate of autistic individuals. However, the human development index of countries was negatively associated with the pooled prevalence, which could be attributed to the different levels of awareness, diagnostic technologies, and autism-service support worldwide. About 1/10 autistic individuals also had epilepsy, which was common in the clinical setting, adolescents, adults, females, or patients with intellectual disability and less common in the country with high human development index. Thus, these findings provided critical and innovative views on the prevalence of epilepsy in autistic individuals and contributed to the targeted clinical management and preventive measures. En ligne : http://dx.doi.org/10.1177/13623613211045029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / X. LIU, Auteur ; X. SUN, Auteur ; C. SUN, Auteur ; M. ZOU, Auteur ; Y. CHEN, Auteur ; J. HUANG, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur . - p.33-50. Langues : Anglais (eng) in Autism > 26-1 (January 2022) . - p.33-50 Mots-clés : adulthood  autism spectrum disorder (ASD)  childhood  co-occurrence  epilepsy  meta-analyses Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence. A total of 66 studies from 53 articles were included in this study. The results showed that epilepsy is more common in autistic individuals than in the general population. The prevalence of epilepsy in autistic individuals in the clinical sample-based studies was higher than that in the population-based based cross-sectional or cohort studies. The prevalence of epilepsy in autistic adults was higher than that in autistic children. A significantly increased prevalence of epilepsy was detected in the autistic adolescent group (11-17?years old), and a higher trend of prevalence of epilepsy was observed in the autistic pre-school group (??6?-years-old) than that of the autistic school-aged group (7-10?years-old). The prevalence of epilepsy increased with age, female rate, and low intellectual function rate of autistic individuals. However, the human development index of countries was negatively associated with the pooled prevalence, which could be attributed to the different levels of awareness, diagnostic technologies, and autism-service support worldwide. About 1/10 autistic individuals also had epilepsy, which was common in the clinical setting, adolescents, adults, females, or patients with intellectual disability and less common in the country with high human development index. Thus, these findings provided critical and innovative views on the prevalence of epilepsy in autistic individuals and contributed to the targeted clinical management and preventive measures. En ligne : http://dx.doi.org/10.1177/13623613211045029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

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