Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements / Xing-Lian LIU ; Li-Zi LIN ; Xin WANG ; Ming-Hui LI ; Mei-Xia DAI ; Mu-Qing CAO ; Xiu-Hong LI ; Jing JIN ; Hai-Qing XU ; Li CAI in Autism Research, 17-1 (January 2024)  

Public ISBD [article]  inAutism Research > 17-1 (January 2024) . - p.172-181 Titre : Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements Type de document : Texte imprimé et/ou numérique Auteurs : Xing-Lian LIU, Auteur ; Li-Zi LIN, Auteur ; Xin WANG, Auteur ; Ming-Hui LI, Auteur ; Mei-Xia DAI, Auteur ; Mu-Qing CAO, Auteur ; Xiu-Hong LI, Auteur ; Jing JIN, Auteur ; Hai-Qing XU, Auteur ; Li CAI, Auteur Article en page(s) : p.172-181 Index. décimale : PER Périodiques Résumé : Abstract There is limited evidence on the associations of unintended pregnancy with autism spectrum disorders (ASD). This study aimed to examine this relationship and the modification of pre-conceptional and prenatal folic acid supplements. Six thousand and five toddlers aged 16 to 30?months from seven cities of six provinces in China were eligible for participation. Information on unintended pregnancy and folic acid supplements was obtained via questionnaires from caregivers of toddlers. The diagnosis of ASD was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Chinese version of the Childhood Autism Rating Scale (CARS). Of the 6005 toddlers in the study (3337 boys and 2668 girls), 71 (1.18%) received the diagnosis of ASD. Generalized linear models with a logit link function showed unintended pregnancy was positively associated with ASD (odds ratios [OR]?=?1.69, 95% confidence interval [CI], 1.05?2.79). Stratified estimates indicated that the association remained stable among toddlers of mothers without pre-conceptional and prenatal folic acid supplements (OR?=?2.75, 95% CI, 1.04?7.27; n?=?1243, 20.70%). Unintended pregnancy was associated with higher odds of ASD in 16?30?months of toddlers, and the association was consistent among toddlers of mothers without prenatal folic acid supplements. Our findings emphasize the need to raise awareness of the risk of unintended pregnancy and the benefits of folic acid supplements among Chinese women. En ligne : https://doi.org/10.1002/aur.3070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements [Texte imprimé et/ou numérique] / Xing-Lian LIU, Auteur ; Li-Zi LIN, Auteur ; Xin WANG, Auteur ; Ming-Hui LI, Auteur ; Mei-Xia DAI, Auteur ; Mu-Qing CAO, Auteur ; Xiu-Hong LI, Auteur ; Jing JIN, Auteur ; Hai-Qing XU, Auteur ; Li CAI, Auteur . - p.172-181. in Autism Research > 17-1 (January 2024) . - p.172-181 Index. décimale : PER Périodiques Résumé : Abstract There is limited evidence on the associations of unintended pregnancy with autism spectrum disorders (ASD). This study aimed to examine this relationship and the modification of pre-conceptional and prenatal folic acid supplements. Six thousand and five toddlers aged 16 to 30?months from seven cities of six provinces in China were eligible for participation. Information on unintended pregnancy and folic acid supplements was obtained via questionnaires from caregivers of toddlers. The diagnosis of ASD was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Chinese version of the Childhood Autism Rating Scale (CARS). Of the 6005 toddlers in the study (3337 boys and 2668 girls), 71 (1.18%) received the diagnosis of ASD. Generalized linear models with a logit link function showed unintended pregnancy was positively associated with ASD (odds ratios [OR]?=?1.69, 95% confidence interval [CI], 1.05?2.79). Stratified estimates indicated that the association remained stable among toddlers of mothers without pre-conceptional and prenatal folic acid supplements (OR?=?2.75, 95% CI, 1.04?7.27; n?=?1243, 20.70%). Unintended pregnancy was associated with higher odds of ASD in 16?30?months of toddlers, and the association was consistent among toddlers of mothers without prenatal folic acid supplements. Our findings emphasize the need to raise awareness of the risk of unintended pregnancy and the benefits of folic acid supplements among Chinese women. En ligne : https://doi.org/10.1002/aur.3070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability / Ning PAN in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1348-1357 Titre : Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur Article en page(s) : p.1348-1357 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD?+?ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD?+?ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12?years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD?+?ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p? En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability [Texte imprimé et/ou numérique] / Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur . - p.1348-1357. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1348-1357 Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD?+?ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD?+?ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12?years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD?+?ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p? En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years / Xin WANG in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1675-1685 Titre : Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years Type de document : Texte imprimé et/ou numérique Auteurs : Xin WANG, Auteur ; Mei-Xia DAI, Auteur ; Aja MURRAY, Auteur ; Si-Yu LIU, Auteur ; Jia-Jie CHEN, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur ; Bonnie AUYEUNG, Auteur Article en page(s) : p.1675-1685 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/psychology  Child  Empathy  Female  Humans  Intelligence  Male  Psychometrics  Reproducibility of Results  autism spectrum disorder  children  empathy quotient  gender differences  systemizing quotient Index. décimale : PER Périodiques Résumé : We aimed to validate the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in Mainland China, which can reflect the profiles of empathizing and systemizing, and describing specific characteristics of autism spectrum disorder (ASD) and gender-typical behaviors in general population. A total of 800 typically developing (TD) children, aged 4-12years was recruited initially with whose parents/guardians complete the measurements, and 782 TD children who met inclusion criteria were finally included. A 23-item three-factor EQ-C and a 22-item four-factor SQ-C was developed with good internal consistency (Omega total values of 0.87 and 0.86) and test-retest reliability (Pearson correlation coefficients of 0.82 and 0.69). In TD children, girls scored significantly higher on EQ-C (31.4Â+7.8 vs. 28.2Â+7.7) but there were no gender differences in SQ-C scores. TD children showed different cognitive styles (empathizing-dominant for girls with 42.6% identified as Type E; systemizing-dominant for boys with 40.7% identified as Type S). A further sample of 222 children with ASD indicated that they scored lower on EQ/SQ-C compared to TD children (13.2Â+5.1 vs. 29.7Â+7.9, 12.4Â+5.8 vs. 23.5Â+8.3) and were generally systemizing-dominant (Type S: 50.8% for boys and 64.0% for girls). Autistic children scored higher on the SQ-C in those without intellectual disability and with higher paternal education level and family income (14.2Â+6.1 vs. 10.9Â+5.0, 13.3Â+6.2 vs. 11.5Â+5.1, 13.7Â+5.6 vs. 11.9Â+5.8), while there were no differences in the EQ-C. This study indicated good reliability and validity of the Chinese version of EQ/SQ-C, which can be used in Chinese children with and without ASD. LAY SUMMARY: We developed the Chinese version of the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in 782 typically developing (TD) children aged 4-12years in Mainland China, yielding a 23-item, 3-factor EQ-C and a 22-item, 4-factor SQ-C with good psychometric properties. In TD children, we found gender difference only in scores of EQ-C. Further analyses of 222 autistic children indicated that differences were found in scores of SQ-C when considering their gender, intelligence and socio-economic status. En ligne : http://dx.doi.org/10.1002/aur.2743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years [Texte imprimé et/ou numérique] / Xin WANG, Auteur ; Mei-Xia DAI, Auteur ; Aja MURRAY, Auteur ; Si-Yu LIU, Auteur ; Jia-Jie CHEN, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur ; Bonnie AUYEUNG, Auteur . - p.1675-1685. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1675-1685 Mots-clés : Autism Spectrum Disorder/psychology  Child  Empathy  Female  Humans  Intelligence  Male  Psychometrics  Reproducibility of Results  autism spectrum disorder  children  empathy quotient  gender differences  systemizing quotient Index. décimale : PER Périodiques Résumé : We aimed to validate the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in Mainland China, which can reflect the profiles of empathizing and systemizing, and describing specific characteristics of autism spectrum disorder (ASD) and gender-typical behaviors in general population. A total of 800 typically developing (TD) children, aged 4-12years was recruited initially with whose parents/guardians complete the measurements, and 782 TD children who met inclusion criteria were finally included. A 23-item three-factor EQ-C and a 22-item four-factor SQ-C was developed with good internal consistency (Omega total values of 0.87 and 0.86) and test-retest reliability (Pearson correlation coefficients of 0.82 and 0.69). In TD children, girls scored significantly higher on EQ-C (31.4Â+7.8 vs. 28.2Â+7.7) but there were no gender differences in SQ-C scores. TD children showed different cognitive styles (empathizing-dominant for girls with 42.6% identified as Type E; systemizing-dominant for boys with 40.7% identified as Type S). A further sample of 222 children with ASD indicated that they scored lower on EQ/SQ-C compared to TD children (13.2Â+5.1 vs. 29.7Â+7.9, 12.4Â+5.8 vs. 23.5Â+8.3) and were generally systemizing-dominant (Type S: 50.8% for boys and 64.0% for girls). Autistic children scored higher on the SQ-C in those without intellectual disability and with higher paternal education level and family income (14.2Â+6.1 vs. 10.9Â+5.0, 13.3Â+6.2 vs. 11.5Â+5.1, 13.7Â+5.6 vs. 11.9Â+5.8), while there were no differences in the EQ-C. This study indicated good reliability and validity of the Chinese version of EQ/SQ-C, which can be used in Chinese children with and without ASD. LAY SUMMARY: We developed the Chinese version of the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in 782 typically developing (TD) children aged 4-12years in Mainland China, yielding a 23-item, 3-factor EQ-C and a 22-item, 4-factor SQ-C with good psychometric properties. In TD children, we found gender difference only in scores of EQ-C. Further analyses of 222 autistic children indicated that differences were found in scores of SQ-C when considering their gender, intelligence and socio-economic status. En ligne : http://dx.doi.org/10.1002/aur.2743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire / Si-Yu LIU in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1732-1741 Titre : The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire Type de document : Texte imprimé et/ou numérique Auteurs : Si-Yu LIU, Auteur ; Xin WANG, Auteur ; Qiang CHEN, Auteur ; Jia-Jie CHEN, Auteur ; Cheng-Kai JIN, Auteur ; Xiao-Ling ZHAN, Auteur ; Cui-Hua GUO, Auteur ; Xiu-Hong LI, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur Article en page(s) : p.1732-1741 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  China  Communication  Humans  Psychometrics  Reproducibility of Results  Surveys and Questionnaires  Social Communication Questionnaire  autism spectrum disorder  reliability  validity Index. décimale : PER Périodiques Résumé : This study aims to validate the simplified Chinese version of the Social Communication Questionnaire (SCQ) in children aged 2-12years from both general and clinical populations. We recruited 819 Chinese children in this study, including 505 typically developing (TD) children, 202 children with autism spectrum disorder (ASD) and 112 children with non-ASD neurodevelopmental disorders. All the children's parents completed the simplified Chinese version of the SCQ and all children with ASD were additionally assessed for intelligence and the Childhood Autism Rating Scale to confirm their diagnosis. We have developed a 40-item, 4-factor structure of SCQ with two domains (social communication and social interaction; and restricted, repetitive, and stereotyped patterns of behavior), which showed adequate goodness of fit (comparative fit index [CFI] = 0.96, Tucker-Lewisindex [TLI] = 0.95, standardized root mean squared residual [SRMR] = 0.07, root mean square error of approximation [RMSEA] = 0.05), with good internal consistency (Cronbach's alpha = 0.92). We have provided different cut-offs to distinguish ASD cases from TD children (11 for children under 4years [sensitivity: 0.96, specificity: 0.95], 12 for children 4years and above [sensitivity: 0.93, specificity: 0.98]) or children with other neurodevelopmental disorders (14 [sensitivity: 0.85, specificity: 0.88]). Through this large sample validation, we confirmed that the simplified Chinese version of the SCQ could be used for children aged 2-12years with relatively good psychometric properties. LAY SUMMARY: We aimed to develop the simplified Chinese version of the Social Communication Questionnaire (SCQ) for Chinese children aged 2-12years as a screening tool to identified potential risk of autism spectrum disorder (ASD). We have developed a 40-item, 4-factor structure of SCQ with two domains, which showed adequate goodness of fit and good psychometric properties. We also provided different cut-offs to identify ASD cases in general or clinical populations. En ligne : http://dx.doi.org/10.1002/aur.2726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire [Texte imprimé et/ou numérique] / Si-Yu LIU, Auteur ; Xin WANG, Auteur ; Qiang CHEN, Auteur ; Jia-Jie CHEN, Auteur ; Cheng-Kai JIN, Auteur ; Xiao-Ling ZHAN, Auteur ; Cui-Hua GUO, Auteur ; Xiu-Hong LI, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur . - p.1732-1741. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1732-1741 Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  China  Communication  Humans  Psychometrics  Reproducibility of Results  Surveys and Questionnaires  Social Communication Questionnaire  autism spectrum disorder  reliability  validity Index. décimale : PER Périodiques Résumé : This study aims to validate the simplified Chinese version of the Social Communication Questionnaire (SCQ) in children aged 2-12years from both general and clinical populations. We recruited 819 Chinese children in this study, including 505 typically developing (TD) children, 202 children with autism spectrum disorder (ASD) and 112 children with non-ASD neurodevelopmental disorders. All the children's parents completed the simplified Chinese version of the SCQ and all children with ASD were additionally assessed for intelligence and the Childhood Autism Rating Scale to confirm their diagnosis. We have developed a 40-item, 4-factor structure of SCQ with two domains (social communication and social interaction; and restricted, repetitive, and stereotyped patterns of behavior), which showed adequate goodness of fit (comparative fit index [CFI] = 0.96, Tucker-Lewisindex [TLI] = 0.95, standardized root mean squared residual [SRMR] = 0.07, root mean square error of approximation [RMSEA] = 0.05), with good internal consistency (Cronbach's alpha = 0.92). We have provided different cut-offs to distinguish ASD cases from TD children (11 for children under 4years [sensitivity: 0.96, specificity: 0.95], 12 for children 4years and above [sensitivity: 0.93, specificity: 0.98]) or children with other neurodevelopmental disorders (14 [sensitivity: 0.85, specificity: 0.88]). Through this large sample validation, we confirmed that the simplified Chinese version of the SCQ could be used for children aged 2-12years with relatively good psychometric properties. LAY SUMMARY: We aimed to develop the simplified Chinese version of the Social Communication Questionnaire (SCQ) for Chinese children aged 2-12years as a screening tool to identified potential risk of autism spectrum disorder (ASD). We have developed a 40-item, 4-factor structure of SCQ with two domains, which showed adequate goodness of fit and good psychometric properties. We also provided different cut-offs to identify ASD cases in general or clinical populations. En ligne : http://dx.doi.org/10.1002/aur.2726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

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