Children with Autism Spectrum Disorder in Times of COVID-19: Examining Emotional and Behavioral Problems, Parental Well-Being, and Resilience / Donna A. de Maat ; Ruth VAN DER HALLEN ; Pieter F. A. DE NIJS ; Kirsten VISSER ; Dennis BASTIAANSEN ; Femke L. Truijens ; Elisabeth H. M. van Rijen ; Wietske Ester ; Peter PRINZIE ; Pauline W. JANSEN ; Linda P. DEKKER in Journal of Autism and Developmental Disorders, 55-2 (February 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-2 (February 2025) . - p.752-763 Titre : Children with Autism Spectrum Disorder in Times of COVID-19: Examining Emotional and Behavioral Problems, Parental Well-Being, and Resilience : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Donna A. de Maat, Auteur ; Ruth VAN DER HALLEN, Auteur ; Pieter F. A. DE NIJS, Auteur ; Kirsten VISSER, Auteur ; Dennis BASTIAANSEN, Auteur ; Femke L. Truijens, Auteur ; Elisabeth H. M. van Rijen, Auteur ; Wietske Ester, Auteur ; Peter PRINZIE, Auteur ; Pauline W. JANSEN, Auteur ; Linda P. DEKKER, Auteur Article en page(s) : p.752-763 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This longitudinal study assessed the impact of the COVID-19 pandemic on children with autism spectrum disorder (ASD; n = 62; Mage = 13 years) by measuring emotional and behavioral problems before and during the pandemic, and by comparing this change to a matched sample of children without ASD (n = 213; Mage = 16 years). Moreover, we examined whether indicators of parental well-being promoted resilience of children with ASD. Results showed that the mean change in problems did not differ between children with and without ASD. Importantly, some children showed an increase in problems, while others showed resilience. Parental well-being indicators were not related to resilience among children with ASD. The interindividual variability in responses, particularly among children with ASD, highlights the need for personalized support. En ligne : https://doi.org/10.1007/s10803-022-05846-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Children with Autism Spectrum Disorder in Times of COVID-19: Examining Emotional and Behavioral Problems, Parental Well-Being, and Resilience : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Donna A. de Maat, Auteur ; Ruth VAN DER HALLEN, Auteur ; Pieter F. A. DE NIJS, Auteur ; Kirsten VISSER, Auteur ; Dennis BASTIAANSEN, Auteur ; Femke L. Truijens, Auteur ; Elisabeth H. M. van Rijen, Auteur ; Wietske Ester, Auteur ; Peter PRINZIE, Auteur ; Pauline W. JANSEN, Auteur ; Linda P. DEKKER, Auteur . - p.752-763. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-2 (February 2025) . - p.752-763 Index. décimale : PER Périodiques Résumé : This longitudinal study assessed the impact of the COVID-19 pandemic on children with autism spectrum disorder (ASD; n = 62; Mage = 13 years) by measuring emotional and behavioral problems before and during the pandemic, and by comparing this change to a matched sample of children without ASD (n = 213; Mage = 16 years). Moreover, we examined whether indicators of parental well-being promoted resilience of children with ASD. Results showed that the mean change in problems did not differ between children with and without ASD. Importantly, some children showed an increase in problems, while others showed resilience. Parental well-being indicators were not related to resilience among children with ASD. The interindividual variability in responses, particularly among children with ASD, highlights the need for personalized support. En ligne : https://doi.org/10.1007/s10803-022-05846-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Is the association between mothers' autistic traits and childhood autistic traits moderated by maternal pre-pregnancy body mass index? / Alexandros TSOMPANIDIS ; Rama J. WAHAB ; Romy GAILLARD ; Ezra AYDIN ; Rosemary HOLT ; Carrie ALLISON ; Simon BARON-COHEN ; Marinus H. VAN IJZENDOORN ; Pauline W. JANSEN in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 46 p. Titre : Is the association between mothers' autistic traits and childhood autistic traits moderated by maternal pre-pregnancy body mass index? Type de document : Texte imprimé et/ou numérique Auteurs : Alexandros TSOMPANIDIS, Auteur ; Rama J. WAHAB, Auteur ; Romy GAILLARD, Auteur ; Ezra AYDIN, Auteur ; Rosemary HOLT, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Pauline W. JANSEN, Auteur Article en page(s) : 46 p. Langues : Anglais (eng) Mots-clés : Pregnancy  Female  Adolescent  Humans  Child, Preschool  Body Mass Index  *Autistic Disorder  Mothers  Parents  Autistic traits  Children  Pre-pregnancy body mass index Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous studies showed that there is a positive association between mothers' and children's autistic traits. We also tested if this association is more pronounced in mothers with a higher pre-pregnancy body mass index (BMI). METHOD: The study was embedded in two cohorts with information available for 4,659 participants from the Generation R and for 179 participants from the Cambridge Ultrasound Siblings and Parents Project (CUSP) cohort. In both cohorts, maternal autistic traits were assessed using the short form of the Autism Spectrum Quotient, and information about maternal height and weight before pregnancy was obtained by questionnaire. Child autistic traits were assessed with the short form of Social Responsiveness Scale in Generation R (M=13.5 years) and with the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in the CUSP cohort (M=1.6 years). RESULT: Higher maternal autistic traits were associated with higher autistic traits in toddlerhood (CUSP cohort; ?(adjusted)=0.20, p<0.01), in early childhood (Generation R; ?(adjusted)=0.19, p<0.01), and in early adolescence (Generation R; ?(adjusted)=0.16, p<0.01). Furthermore, a higher maternal pre-pregnancy BMI was associated with higher child autistic traits, but only in Generation R (?(adjusted)=0.03, p<0.01). There was no significant moderating effect of maternal pre-pregnancy BMI on the association between autistic traits of mothers and children, neither in Generation R nor in CUSP. In addition, child autistic traits scores were significantly higher in mothers who were underweight and in mothers who were overweight compared to mothers with a healthy weight. CONCLUSION: We confirm the association between maternal and child autistic traits in toddlerhood, early childhood, and early adolescence. Potential interacting neurobiological processes remain to be confirmed. En ligne : https://dx.doi.org/10.1186/s13229-023-00578-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Is the association between mothers' autistic traits and childhood autistic traits moderated by maternal pre-pregnancy body mass index? [Texte imprimé et/ou numérique] / Alexandros TSOMPANIDIS, Auteur ; Rama J. WAHAB, Auteur ; Romy GAILLARD, Auteur ; Ezra AYDIN, Auteur ; Rosemary HOLT, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Pauline W. JANSEN, Auteur . - 46 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 46 p. Mots-clés : Pregnancy  Female  Adolescent  Humans  Child, Preschool  Body Mass Index  *Autistic Disorder  Mothers  Parents  Autistic traits  Children  Pre-pregnancy body mass index Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous studies showed that there is a positive association between mothers' and children's autistic traits. We also tested if this association is more pronounced in mothers with a higher pre-pregnancy body mass index (BMI). METHOD: The study was embedded in two cohorts with information available for 4,659 participants from the Generation R and for 179 participants from the Cambridge Ultrasound Siblings and Parents Project (CUSP) cohort. In both cohorts, maternal autistic traits were assessed using the short form of the Autism Spectrum Quotient, and information about maternal height and weight before pregnancy was obtained by questionnaire. Child autistic traits were assessed with the short form of Social Responsiveness Scale in Generation R (M=13.5 years) and with the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in the CUSP cohort (M=1.6 years). RESULT: Higher maternal autistic traits were associated with higher autistic traits in toddlerhood (CUSP cohort; ?(adjusted)=0.20, p<0.01), in early childhood (Generation R; ?(adjusted)=0.19, p<0.01), and in early adolescence (Generation R; ?(adjusted)=0.16, p<0.01). Furthermore, a higher maternal pre-pregnancy BMI was associated with higher child autistic traits, but only in Generation R (?(adjusted)=0.03, p<0.01). There was no significant moderating effect of maternal pre-pregnancy BMI on the association between autistic traits of mothers and children, neither in Generation R nor in CUSP. In addition, child autistic traits scores were significantly higher in mothers who were underweight and in mothers who were overweight compared to mothers with a healthy weight. CONCLUSION: We confirm the association between maternal and child autistic traits in toddlerhood, early childhood, and early adolescence. Potential interacting neurobiological processes remain to be confirmed. En ligne : https://dx.doi.org/10.1186/s13229-023-00578-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort / Novika Purnama SARI in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 26 p. Titre : Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort Type de document : Texte imprimé et/ou numérique Auteurs : Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/epidemiology  Child  Female  Humans  Male  Maternal Age  Mentalization  Mothers  Netherlands/epidemiology  Pregnancy  Autistic-like traits  Children   Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort [Texte imprimé et/ou numérique] / Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur . - 26 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 26 p. Mots-clés : Autistic Disorder/epidemiology  Child  Female  Humans  Male  Maternal Age  Mentalization  Mothers  Netherlands/epidemiology  Pregnancy  Autistic-like traits  Children   Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population / Holly A. HARRIS ; Gordon D. WAITER ; Pauline W. JANSEN ; Justin H. G. WILLIAMS ; Tonya WHITE in Journal of Child Psychology and Psychiatry, 66-6 (June 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.785-795 Titre : Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population Type de document : Texte imprimé et/ou numérique Auteurs : Holly A. HARRIS, Auteur ; Gordon D. WAITER, Auteur ; Pauline W. JANSEN, Auteur ; Justin H. G. WILLIAMS, Auteur ; Tonya WHITE, Auteur Article en page(s) : p.785-795 Langues : Anglais (eng) Mots-clés : ARFID  eating disorders  MRI  neuroanatomy  BMI  hunger awareness Index. décimale : PER Périodiques Résumé : Background Avoidant restrictive food intake disorder (ARFID) is a recently recognised feeding and eating disorder and is characterised by a lack of interest and motivation to eat. Despite burgeoning research, few studies to date have explored the underlying neurobiology of ARFID. Research examining the neural underpinnings of ARFID can greatly assist in understanding different mechanisms that play disorder-specific roles. Methods We studied a total of 1,977 10-year-old participants from the Generation R Study, a population-based Dutch cohort, to cross-sectionally examine neuroanatomical differences between those with versus without ARFID-like symptoms. Children were classified with versus without ARFID symptoms using the ARFID Index, a validated evaluative tool comprised of parent-reported and researcher-assessed measurements of picky eating, energy intake, diet quality, growth and psychosocial impact to characterise ARFID symptoms in the paediatric population. Global and regional values of surface area, cortical thickness, and volume from T1-weighted structural magnetic resonance imaging (MRI) scans in those with ARFID symptoms were compared with children not exhibiting symptoms. Results We identified 121 (6.1%) individuals with ARFID symptoms relative to 1,865 (93.9%) individuals without ARFID symptoms. Neuroanatomical findings identified significantly greater frontal (p?=?.00743; d?=?0.21) and superior frontal (p?=?6.56E-04; d?=?0.28) cortical thickness among children with ARFID symptoms. Conclusions This first large-scale study of the neural correlates of ARFID identified greater thickness of frontal cortical regions in children with ARFID symptoms, suggesting a role for executive function in the aetiology of the condition. En ligne : https://doi.org/10.1111/jcpp.14086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population [Texte imprimé et/ou numérique] / Holly A. HARRIS, Auteur ; Gordon D. WAITER, Auteur ; Pauline W. JANSEN, Auteur ; Justin H. G. WILLIAMS, Auteur ; Tonya WHITE, Auteur . - p.785-795. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.785-795 Mots-clés : ARFID  eating disorders  MRI  neuroanatomy  BMI  hunger awareness Index. décimale : PER Périodiques Résumé : Background Avoidant restrictive food intake disorder (ARFID) is a recently recognised feeding and eating disorder and is characterised by a lack of interest and motivation to eat. Despite burgeoning research, few studies to date have explored the underlying neurobiology of ARFID. Research examining the neural underpinnings of ARFID can greatly assist in understanding different mechanisms that play disorder-specific roles. Methods We studied a total of 1,977 10-year-old participants from the Generation R Study, a population-based Dutch cohort, to cross-sectionally examine neuroanatomical differences between those with versus without ARFID-like symptoms. Children were classified with versus without ARFID symptoms using the ARFID Index, a validated evaluative tool comprised of parent-reported and researcher-assessed measurements of picky eating, energy intake, diet quality, growth and psychosocial impact to characterise ARFID symptoms in the paediatric population. Global and regional values of surface area, cortical thickness, and volume from T1-weighted structural magnetic resonance imaging (MRI) scans in those with ARFID symptoms were compared with children not exhibiting symptoms. Results We identified 121 (6.1%) individuals with ARFID symptoms relative to 1,865 (93.9%) individuals without ARFID symptoms. Neuroanatomical findings identified significantly greater frontal (p?=?.00743; d?=?0.21) and superior frontal (p?=?6.56E-04; d?=?0.28) cortical thickness among children with ARFID symptoms. Conclusions This first large-scale study of the neural correlates of ARFID identified greater thickness of frontal cortical regions in children with ARFID symptoms, suggesting a role for executive function in the aetiology of the condition. En ligne : https://doi.org/10.1111/jcpp.14086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

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