Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents / Christina BURROUGHS ; Jessica PAPPAGIANOPOULOS ; Eleonora SADIKOVA ; Emily FUHRMANN ; Genevieve BOHAC ; Robert CROSS ; Lauren WITTE ; Gabrielle BRINKMANN ; Rachel LEMLEY ; Denis G. SUKHODOLSKY ; Micah O. MAZUREK in Autism, 28-12 (December 2024)  

Public ISBD [article]  inAutism > 28-12 (December 2024) . - p.3021-3032 Titre : Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Christina BURROUGHS, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Eleonora SADIKOVA, Auteur ; Emily FUHRMANN, Auteur ; Genevieve BOHAC, Auteur ; Robert CROSS, Auteur ; Lauren WITTE, Auteur ; Gabrielle BRINKMANN, Auteur ; Rachel LEMLEY, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Micah O. MAZUREK, Auteur Article en page(s) : p.3021-3032 Langues : Anglais (eng) Mots-clés : anxiety  autism spectrum disorders  depression  interventions-psychosocial/behavioral  psychiatric comorbidity Index. décimale : PER Périodiques Résumé : Depression is common among autistic youth and is associated with worse quality of life in this group. Despite significant need for high-quality efficacious treatments, there has been very limited research on interventions for depression in autistic youth. This single-arm pilot study examined the feasibility and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A). BA-A is an individually delivered manualized 12-session treatment that utilizes established BA strategies and incorporates common mental health treatment adaptations for autistic young people. Of the 18 youth (11-16 years old) who enrolled, 15 completed all 12 treatment sessions, as well as pre-treatment, post-treatment, and follow-up assessment visits. Clinician treatment fidelity was quite high. Paired sample t-tests found that depression symptoms decreased pre- to post-BA-A according to multiple informants (i.e. self, caregiver, and independent evaluator), and treatment gains were maintained at 1-month follow-up. Paired sample t-tests also found that caregiver-reported anxiety symptoms and social skills improved pre-treatment to post-treatment. The results, although preliminary, indicate that BA-A may improve depression symptoms in autistic youth without intellectual disability. Furthermore, these promising findings suggest that a randomized controlled trial of BA-A is warranted. This trial was pre-registered at ClinicalTrials.gov (NCT05018169). Lay Abstract Depression is common among autistic youth and has a significant negative impact on quality of life and day-to-day functioning. Despite great need for efficacious treatments, there are currently limited research-supported interventions for depression symptoms in autistic young people. This study tested a novel, behavior-based approach or psychotherapy for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A) with 15 youth (11-16 years old). BA-A is an individually delivered 12-session therapy that was developed for and to meet the needs of autistic youth with depression. Results found that autistic youth and their caregivers were able to participate in BA-A therapy sessions, and clinicians were able to deliver BA-A in accordance with the treatment manual. Notably, results demonstrated that autistic youth depression symptoms significantly improved after participating in BA-A. Furthermore, anxiety symptoms and social skills significantly improved following BA-A. En ligne : https://dx.doi.org/10.1177/13623613241252470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543 [article] Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents [Texte imprimé et/ou numérique] / Christina BURROUGHS, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Eleonora SADIKOVA, Auteur ; Emily FUHRMANN, Auteur ; Genevieve BOHAC, Auteur ; Robert CROSS, Auteur ; Lauren WITTE, Auteur ; Gabrielle BRINKMANN, Auteur ; Rachel LEMLEY, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Micah O. MAZUREK, Auteur . - p.3021-3032. Langues : Anglais (eng) in Autism > 28-12 (December 2024) . - p.3021-3032 Mots-clés : anxiety  autism spectrum disorders  depression  interventions-psychosocial/behavioral  psychiatric comorbidity Index. décimale : PER Périodiques Résumé : Depression is common among autistic youth and is associated with worse quality of life in this group. Despite significant need for high-quality efficacious treatments, there has been very limited research on interventions for depression in autistic youth. This single-arm pilot study examined the feasibility and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A). BA-A is an individually delivered manualized 12-session treatment that utilizes established BA strategies and incorporates common mental health treatment adaptations for autistic young people. Of the 18 youth (11-16 years old) who enrolled, 15 completed all 12 treatment sessions, as well as pre-treatment, post-treatment, and follow-up assessment visits. Clinician treatment fidelity was quite high. Paired sample t-tests found that depression symptoms decreased pre- to post-BA-A according to multiple informants (i.e. self, caregiver, and independent evaluator), and treatment gains were maintained at 1-month follow-up. Paired sample t-tests also found that caregiver-reported anxiety symptoms and social skills improved pre-treatment to post-treatment. The results, although preliminary, indicate that BA-A may improve depression symptoms in autistic youth without intellectual disability. Furthermore, these promising findings suggest that a randomized controlled trial of BA-A is warranted. This trial was pre-registered at ClinicalTrials.gov (NCT05018169). Lay Abstract Depression is common among autistic youth and has a significant negative impact on quality of life and day-to-day functioning. Despite great need for efficacious treatments, there are currently limited research-supported interventions for depression symptoms in autistic young people. This study tested a novel, behavior-based approach or psychotherapy for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A) with 15 youth (11-16 years old). BA-A is an individually delivered 12-session therapy that was developed for and to meet the needs of autistic youth with depression. Results found that autistic youth and their caregivers were able to participate in BA-A therapy sessions, and clinicians were able to deliver BA-A in accordance with the treatment manual. Notably, results demonstrated that autistic youth depression symptoms significantly improved after participating in BA-A. Furthermore, anxiety symptoms and social skills significantly improved following BA-A. En ligne : https://dx.doi.org/10.1177/13623613241252470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543

Inner experiences, mental health, and well-being in autistic and non-autistic adults / Micah O. MAZUREK in Autism Research, 17-12 (December 2024)  

Public ISBD [article]  inAutism Research > 17-12 (December 2024) . - p.2676-2688 Titre : Inner experiences, mental health, and well-being in autistic and non-autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : Micah O. MAZUREK, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Sophie BRUNT, Auteur ; Rose NEVILL, Auteur ; Michelle MENEZES, Auteur ; Christina BURROUGHS, Auteur ; Eleonora SADIKOVA, Auteur ; Jessica V. SMITH, Auteur ; Mya HOWARD, Auteur Article en page(s) : p.2676-2688 Langues : Anglais (eng) Mots-clés : autism  inner speech  mental health  self-talk  verbal thinking  visual thinking Index. décimale : PER Périodiques Résumé : Abstract The nature of autistic adults' everyday inner experiences has been largely unstudied. The purpose of this study was to examine patterns of inner experiences and how they relate to mental health and wellness among autistic and non-autistic adults. Autistic (n?=?303) and non-autistic (n?=?289) adults (ages 21?82) completed online surveys assessing their anxiety, depression, happiness, life satisfaction, and inner thinking patterns, (inner speaking [i.e., verbal thinking], inner seeing [i.e., visual thinking], unsymbolized thinking, feelings, sensory awareness, self-talk). Group differences in inner thinking were examined using Mann?Whitney U and chi-square tests. Correlations and multiple linear regressions examined associations between inner experiences, mental health, and well-being. Autistic adults had greater use of inner speaking and sensory awareness, compared to non-autistic adults. The most common primary mode of inner experience for both groups was inner speaking, while fewer autistic adults reported that experiencing thoughts as feelings was their primary modality. Autistic adults reported greater use of self-talk for social assessment, self-criticism, and self-management purposes, compared to non-autistic adults. Experiencing thoughts as inner speech and as feelings were associated with anxiety in both groups. Using self-talk for social assessment and self-criticism purposes was correlated with anxiety and depression in both groups, while using self-talk for self-management was associated with depression and anxiety only among autistic adults. The results suggest that autistic and non-autistic adults have similarities in overall patterns of inner thinking, yet autistic adults may be more likely to engage in self-talk as a strategy to manage challenging day-to-day experiences. En ligne : https://dx.doi.org/10.1002/aur.3273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] Inner experiences, mental health, and well-being in autistic and non-autistic adults [Texte imprimé et/ou numérique] / Micah O. MAZUREK, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Sophie BRUNT, Auteur ; Rose NEVILL, Auteur ; Michelle MENEZES, Auteur ; Christina BURROUGHS, Auteur ; Eleonora SADIKOVA, Auteur ; Jessica V. SMITH, Auteur ; Mya HOWARD, Auteur . - p.2676-2688. Langues : Anglais (eng) in Autism Research > 17-12 (December 2024) . - p.2676-2688 Mots-clés : autism  inner speech  mental health  self-talk  verbal thinking  visual thinking Index. décimale : PER Périodiques Résumé : Abstract The nature of autistic adults' everyday inner experiences has been largely unstudied. The purpose of this study was to examine patterns of inner experiences and how they relate to mental health and wellness among autistic and non-autistic adults. Autistic (n?=?303) and non-autistic (n?=?289) adults (ages 21?82) completed online surveys assessing their anxiety, depression, happiness, life satisfaction, and inner thinking patterns, (inner speaking [i.e., verbal thinking], inner seeing [i.e., visual thinking], unsymbolized thinking, feelings, sensory awareness, self-talk). Group differences in inner thinking were examined using Mann?Whitney U and chi-square tests. Correlations and multiple linear regressions examined associations between inner experiences, mental health, and well-being. Autistic adults had greater use of inner speaking and sensory awareness, compared to non-autistic adults. The most common primary mode of inner experience for both groups was inner speaking, while fewer autistic adults reported that experiencing thoughts as feelings was their primary modality. Autistic adults reported greater use of self-talk for social assessment, self-criticism, and self-management purposes, compared to non-autistic adults. Experiencing thoughts as inner speech and as feelings were associated with anxiety in both groups. Using self-talk for social assessment and self-criticism purposes was correlated with anxiety and depression in both groups, while using self-talk for self-management was associated with depression and anxiety only among autistic adults. The results suggest that autistic and non-autistic adults have similarities in overall patterns of inner thinking, yet autistic adults may be more likely to engage in self-talk as a strategy to manage challenging day-to-day experiences. En ligne : https://dx.doi.org/10.1002/aur.3273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder / Blythe A. CORBETT ; Alexandra P. KEY ; Mark E. KLEMENCIC ; Rachael A. MUSCATELLO ; Dorita JONES ; Jennifer Pilkington ; Christina BURROUGHS ; Simon VANDEKAR in Journal of Autism and Developmental Disorders, 55-1 (January 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.130-146 Titre : Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Mark E. KLEMENCIC, Auteur ; Rachael A. MUSCATELLO, Auteur ; Dorita JONES, Auteur ; Jennifer Pilkington, Auteur ; Christina BURROUGHS, Auteur ; Simon VANDEKAR, Auteur Article en page(s) : p.130-146 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by challenges in social competence that persist in adulthood, yet few treatment options exist. A pilot randomized clinical trial (RCT) of a peer-mediated, theatre-based intervention with established efficacy in youth with ASD was examined in autistic adults. The final sample consisted of forty-seven 18-to-40-year-old participants randomized to the experimental (EXP N = 23) or waitlist control (WLC N = 24) condition. A multimodal, social interdependent model was employed to examine social competence changes in brain (incidental face memory (IFM) using event-related potentials), cognition (Wechsler Memory Scale-III), behavior (Contextual Assessment of Social Skills) and function (Social Responsiveness Scale (SRS); Adaptive Behavior Assessment Scale (ABAS) Social Composite). Using analysis of covariance in which pretest was controlled in the model, posttest between-group differences were observed on IFM (p = 0.016, ?2 = 0.139, d = 0.79) and several social and adaptive functional (SRS, ABAS) outcomes in social communication and interaction (SCI) (p = 0.019, ?2 = 0.121, d = -00.45), communication (p = 0.044 ?2 = 0.09, d = -00.31), and motivation (p = 0.001, ?2 = 0.229, d = -0.79) domains. At two-month follow-up, gains in social motivation remained (p = 0.041, ?2 = 0.100, d = -0.77). The results offer preliminary support for a unique theatre-based social skills intervention for autistic adults who have few treatment options to enhance social competence. The trial was pre-registered with ClinicalTrials.gov (Identifier: NCT04349644). En ligne : https://doi.org/10.1007/s10803-023-06214-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Mark E. KLEMENCIC, Auteur ; Rachael A. MUSCATELLO, Auteur ; Dorita JONES, Auteur ; Jennifer Pilkington, Auteur ; Christina BURROUGHS, Auteur ; Simon VANDEKAR, Auteur . - p.130-146. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.130-146 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by challenges in social competence that persist in adulthood, yet few treatment options exist. A pilot randomized clinical trial (RCT) of a peer-mediated, theatre-based intervention with established efficacy in youth with ASD was examined in autistic adults. The final sample consisted of forty-seven 18-to-40-year-old participants randomized to the experimental (EXP N = 23) or waitlist control (WLC N = 24) condition. A multimodal, social interdependent model was employed to examine social competence changes in brain (incidental face memory (IFM) using event-related potentials), cognition (Wechsler Memory Scale-III), behavior (Contextual Assessment of Social Skills) and function (Social Responsiveness Scale (SRS); Adaptive Behavior Assessment Scale (ABAS) Social Composite). Using analysis of covariance in which pretest was controlled in the model, posttest between-group differences were observed on IFM (p = 0.016, ?2 = 0.139, d = 0.79) and several social and adaptive functional (SRS, ABAS) outcomes in social communication and interaction (SCI) (p = 0.019, ?2 = 0.121, d = -00.45), communication (p = 0.044 ?2 = 0.09, d = -00.31), and motivation (p = 0.001, ?2 = 0.229, d = -0.79) domains. At two-month follow-up, gains in social motivation remained (p = 0.041, ?2 = 0.100, d = -0.77). The results offer preliminary support for a unique theatre-based social skills intervention for autistic adults who have few treatment options to enhance social competence. The trial was pre-registered with ClinicalTrials.gov (Identifier: NCT04349644). En ligne : https://doi.org/10.1007/s10803-023-06214-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth / Blythe A. CORBETT in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 18p. Titre : Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Trey MCGONIGLE, Auteur ; Simon VANDEKAR, Auteur ; Christina BURROUGHS, Auteur ; Sloane SPARKS, Auteur Article en page(s) : 18p. Langues : Anglais (eng) Mots-clés : Humans  Female  Male  Adolescent  Depression/epidemiology  Child  Longitudinal Studies  Autism Spectrum Disorder/psychology/epidemiology  Autistic Disorder/psychology/epidemiology  Puberty/psychology  Adolescence  Autism  Depression  Development  Puberty Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence coincides with a dramatic rise in the onset of psychiatric conditions including depression. Depression symptoms may be particularly prevalent and impairing for youth with autism spectrum disorder (ASD). While prior research suggests adolescence is associated with worsening depression symptoms for typically developing (TD) and autistic youth, it is unclear if they follow a similar course. METHOD: The study examined the trajectory of depressive symptoms in autistic and neurotypical youth over a 4-year longitudinal study using linear and logistic mixed effects models. In youth with clinically relevant depressive scores (t-score > 65), moderating factors (i.e., diagnosis, age, puberty, sex) were explored. During Year 1, the sample included 244 youth 10-to-13 years: 140 in the ASD group (36 females) and 104 in the TD group (46 females). RESULTS: Autistic youth had elevated depression scores compared to TD peers (p < 0.001) and females were higher than males in both groups (p = 0.001). There was significant diagnosis by age (p < 0.001) and diagnosis by pubertal stage (p < 0.05) interactions. In the ASD group, elevated depressive scores presented in early adolescence and decreased during middle adolescence and puberty, whereas the TD group showed the opposite trend with an increase in depression symptoms with advancing development. LIMITATIONS: Limitations include an unequal sex distribution (fewer females), non-representative autistic sample (e.g., cognition and race/ethnicity), and potential confound of the COVID-19 pandemic. CONCLUSIONS: Autistic youth present with higher rates of depressive symptoms early in development; yet, approaching middle adolescence and puberty, the symptom trajectory in the autistic youth declines coinciding with an increase in the TD youth. While group trajectories are divergent, they lead to similar levels of depression in late adolescence with higher symptoms in females. Findings suggest a period of quiescence in depressive symptomology influenced by biopsychosocial factors impacting affective profiles. En ligne : https://dx.doi.org/10.1186/s13229-024-00600-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Trey MCGONIGLE, Auteur ; Simon VANDEKAR, Auteur ; Christina BURROUGHS, Auteur ; Sloane SPARKS, Auteur . - 18p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 18p. Mots-clés : Humans  Female  Male  Adolescent  Depression/epidemiology  Child  Longitudinal Studies  Autism Spectrum Disorder/psychology/epidemiology  Autistic Disorder/psychology/epidemiology  Puberty/psychology  Adolescence  Autism  Depression  Development  Puberty Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence coincides with a dramatic rise in the onset of psychiatric conditions including depression. Depression symptoms may be particularly prevalent and impairing for youth with autism spectrum disorder (ASD). While prior research suggests adolescence is associated with worsening depression symptoms for typically developing (TD) and autistic youth, it is unclear if they follow a similar course. METHOD: The study examined the trajectory of depressive symptoms in autistic and neurotypical youth over a 4-year longitudinal study using linear and logistic mixed effects models. In youth with clinically relevant depressive scores (t-score > 65), moderating factors (i.e., diagnosis, age, puberty, sex) were explored. During Year 1, the sample included 244 youth 10-to-13 years: 140 in the ASD group (36 females) and 104 in the TD group (46 females). RESULTS: Autistic youth had elevated depression scores compared to TD peers (p < 0.001) and females were higher than males in both groups (p = 0.001). There was significant diagnosis by age (p < 0.001) and diagnosis by pubertal stage (p < 0.05) interactions. In the ASD group, elevated depressive scores presented in early adolescence and decreased during middle adolescence and puberty, whereas the TD group showed the opposite trend with an increase in depression symptoms with advancing development. LIMITATIONS: Limitations include an unequal sex distribution (fewer females), non-representative autistic sample (e.g., cognition and race/ethnicity), and potential confound of the COVID-19 pandemic. CONCLUSIONS: Autistic youth present with higher rates of depressive symptoms early in development; yet, approaching middle adolescence and puberty, the symptom trajectory in the autistic youth declines coinciding with an increase in the TD youth. While group trajectories are divergent, they lead to similar levels of depression in late adolescence with higher symptoms in females. Findings suggest a period of quiescence in depressive symptomology influenced by biopsychosocial factors impacting affective profiles. En ligne : https://dx.doi.org/10.1186/s13229-024-00600-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

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