Alternative treatments for autism: Prevalence and predictors / Kim M. JONKMAN in Research in Autism Spectrum Disorders, 98 (October 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 98 (October 2022) . - 102046 Titre : Alternative treatments for autism: Prevalence and predictors Type de document : Texte imprimé et/ou numérique Auteurs : Kim M. JONKMAN, Auteur ; Elisa BACK, Auteur ; Wouter G. STAAL, Auteur ; Lotte BENARD, Auteur ; Daniël M. VAN DER DOELEN, Auteur ; Sander BEGEER, Auteur Article en page(s) : 102046 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Complementary and alternative medicine  Complementary health approaches Index. décimale : PER Périodiques Résumé : Autism is a heterogeneous neurodevelopmental disorder for which a large variety of treatments are offered, including alternative treatments. Vaccine-related treatments (treatments falsely claiming to cure autism by addressing its alleged cause: routine childhood vaccines such as MMR) continue to be offered worldwide, despite widespread evidence against the effectiveness and even possible harm related to these treatments. We analysed the use of alternative treatments in two studies: a survey study (N = 1989, autistic adults and parents/legal representatives of individuals with autism) and a clinical care study (N = 4520, patient files from a treatment center for autism). Both studies found a relatively high frequency of alternative treatments (23.0-30.7%) - in children even 46.4% -, mostly in combination with mainstream treatment. In the survey study vaccine-related treatments were used by 3.2% of all individuals with autism (and 6.7% of autistic children), and alternative treatment use was predicted by co-occurring diagnoses, younger age of diagnosis and mainstream treatment use. In the clinical care study, patients who had received treatment from a homeo-/osteopath more often had highly educated parents from Dutch/Western background and were more often enrolled in special education. Alternative treatments are widely used and should be included in treatment guidelines. Parents, practitioners and individuals with autism should be both advised and warned about the benefits and risks of these treatments. More research is needed to better understand the choice for and effect of alternative treatments for autism, and mainstream care should be improved. En ligne : https://doi.org/10.1016/j.rasd.2022.102046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Alternative treatments for autism: Prevalence and predictors [Texte imprimé et/ou numérique] / Kim M. JONKMAN, Auteur ; Elisa BACK, Auteur ; Wouter G. STAAL, Auteur ; Lotte BENARD, Auteur ; Daniël M. VAN DER DOELEN, Auteur ; Sander BEGEER, Auteur . - 102046. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 98 (October 2022) . - 102046 Mots-clés : Autism spectrum disorder  Complementary and alternative medicine  Complementary health approaches Index. décimale : PER Périodiques Résumé : Autism is a heterogeneous neurodevelopmental disorder for which a large variety of treatments are offered, including alternative treatments. Vaccine-related treatments (treatments falsely claiming to cure autism by addressing its alleged cause: routine childhood vaccines such as MMR) continue to be offered worldwide, despite widespread evidence against the effectiveness and even possible harm related to these treatments. We analysed the use of alternative treatments in two studies: a survey study (N = 1989, autistic adults and parents/legal representatives of individuals with autism) and a clinical care study (N = 4520, patient files from a treatment center for autism). Both studies found a relatively high frequency of alternative treatments (23.0-30.7%) - in children even 46.4% -, mostly in combination with mainstream treatment. In the survey study vaccine-related treatments were used by 3.2% of all individuals with autism (and 6.7% of autistic children), and alternative treatment use was predicted by co-occurring diagnoses, younger age of diagnosis and mainstream treatment use. In the clinical care study, patients who had received treatment from a homeo-/osteopath more often had highly educated parents from Dutch/Western background and were more often enrolled in special education. Alternative treatments are widely used and should be included in treatment guidelines. Parents, practitioners and individuals with autism should be both advised and warned about the benefits and risks of these treatments. More research is needed to better understand the choice for and effect of alternative treatments for autism, and mainstream care should be improved. En ligne : https://doi.org/10.1016/j.rasd.2022.102046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) / Wouter G. STAAL in Journal of Autism and Developmental Disorders, 42-5 (May 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.885-888 Titre : Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Wouter G. STAAL, Auteur ; Mariken DE KROM, Auteur ; Maretha V. DE JONGE, Auteur Année de publication : 2012 Article en page(s) : p.885-888 Langues : Anglais (eng) Mots-clés : DRD3  rs167771  Autism  Stereotyped behavior Index. décimale : PER Périodiques Résumé : Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor “insistence on sameness” (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing. En ligne : http://dx.doi.org/10.1007/s10803-011-1312-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 [article] Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / Wouter G. STAAL, Auteur ; Mariken DE KROM, Auteur ; Maretha V. DE JONGE, Auteur . - 2012 . - p.885-888. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.885-888 Mots-clés : DRD3  rs167771  Autism  Stereotyped behavior Index. décimale : PER Périodiques Résumé : Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor “insistence on sameness” (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing. En ligne : http://dx.doi.org/10.1007/s10803-011-1312-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154

Morphological Features in Children with Autism Spectrum Disorders: A Matched Case–Control Study / Heval M. OZGEN in Journal of Autism and Developmental Disorders, 41-1 (January 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.23-31 Titre : Morphological Features in Children with Autism Spectrum Disorders: A Matched Case–Control Study Type de document : Texte imprimé et/ou numérique Auteurs : Heval M. OZGEN, Auteur ; Gerhard S. HELLEMAN, Auteur ; Rebecca K. STELLATO, Auteur ; Bertine LAHUIS, Auteur ; Emma VAN DAALEN, Auteur ; Wouter G. STAAL, Auteur ; Marije ROZENDAL, Auteur ; Raoul C. HENNEKAM, Auteur ; Frits A. BEEMER, Auteur ; Herman VAN ENGELAND, Auteur Année de publication : 2011 Article en page(s) : p.23-31 Langues : Anglais (eng) Mots-clés : Minor anomalies  Common variants  Dysmorphology  Heterogeneity  Etiology  Biological marker Index. décimale : PER Périodiques Résumé : This study was designed to examine morphological features in a large group of children with autism spectrum disorder versus normal controls. Amongst 421 patients and 1,007 controls, 224 matched pairs were created. Prevalence rates and odds ratios were analyzed by conditional regression analysis, McNemar test or paired t-test matched pairs. Morphological abnormalities were significantly more prevalent in patients with autism than in the normal control group and 48 morphological features distinguished patients from controls. Our findings show that morphological features are associated with autism. Exploring potential underlying genetic mechanisms of this association might lead to a better understanding of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1018-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Morphological Features in Children with Autism Spectrum Disorders: A Matched Case–Control Study [Texte imprimé et/ou numérique] / Heval M. OZGEN, Auteur ; Gerhard S. HELLEMAN, Auteur ; Rebecca K. STELLATO, Auteur ; Bertine LAHUIS, Auteur ; Emma VAN DAALEN, Auteur ; Wouter G. STAAL, Auteur ; Marije ROZENDAL, Auteur ; Raoul C. HENNEKAM, Auteur ; Frits A. BEEMER, Auteur ; Herman VAN ENGELAND, Auteur . - 2011 . - p.23-31. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.23-31 Mots-clés : Minor anomalies  Common variants  Dysmorphology  Heterogeneity  Etiology  Biological marker Index. décimale : PER Périodiques Résumé : This study was designed to examine morphological features in a large group of children with autism spectrum disorder versus normal controls. Amongst 421 patients and 1,007 controls, 224 matched pairs were created. Prevalence rates and odds ratios were analyzed by conditional regression analysis, McNemar test or paired t-test matched pairs. Morphological abnormalities were significantly more prevalent in patients with autism than in the normal control group and 48 morphological features distinguished patients from controls. Our findings show that morphological features are associated with autism. Exploring potential underlying genetic mechanisms of this association might lead to a better understanding of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1018-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

A Novel 6.14 Mb Duplication of Chromosome 8p21 in a Patient with Autism and Self Mutilation / Heval M. OZGEN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.322-329 Titre : A Novel 6.14 Mb Duplication of Chromosome 8p21 in a Patient with Autism and Self Mutilation Type de document : Texte imprimé et/ou numérique Auteurs : Heval M. OZGEN, Auteur ; Maretha V. DE JONGE, Auteur ; Wouter G. STAAL, Auteur ; John C. BARBER, Auteur ; Marc J. ELEVELD, Auteur ; Frits A. BEEMER, Auteur ; Ron HOCHSTENBACH, Auteur ; Martin POOT, Auteur Année de publication : 2009 Article en page(s) : p.322-329 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorder Array-comparative-genomic-hybridization Developmental-delay Fluorescent-in-situ-hybridization Self-mutilation STMN4 DPYSL2 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders with a strong genetic etiology. Cytogenetic abnormalities have been detected in 5–10% of the patients with autism. In this study, we present the clinical, cytogenetic and array-comparative genomic hybridization (array-CGH) evaluation of a 13-year-old male with severe developmental delay, facial dysmorphic features, autism and self mutilation. The patient was found to carry a de novo duplication of chromosome region 8p21 of minimally 6.14 and maximally 6.58 Mb as ascertained by bacterial artificial chromosome (BAC)-based array-CGH. Hitherto, only a few patients with autism with cytogenetically visible duplications involving the chromosome 8p21 region have been described, but the extent of these duplications has not been determined at the molecular level. This represents the smallest rearrangement of chromosomal region 8p21 as yet found in a patient with autism. For 11 of the 36 genes with known functions located within this duplication clear transcription in the brain was found. Of those the STMN4 and DPYSL2 genes are the most likely candidate genes to be involved in neuronal development, and, if altered in gene-dosage, in the autistic phenotype of our patient. En ligne : http://dx.doi.org/10.1007/s10803-008-0627-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=684 [article] A Novel 6.14 Mb Duplication of Chromosome 8p21 in a Patient with Autism and Self Mutilation [Texte imprimé et/ou numérique] / Heval M. OZGEN, Auteur ; Maretha V. DE JONGE, Auteur ; Wouter G. STAAL, Auteur ; John C. BARBER, Auteur ; Marc J. ELEVELD, Auteur ; Frits A. BEEMER, Auteur ; Ron HOCHSTENBACH, Auteur ; Martin POOT, Auteur . - 2009 . - p.322-329. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.322-329 Mots-clés : Autism-spectrum-disorder Array-comparative-genomic-hybridization Developmental-delay Fluorescent-in-situ-hybridization Self-mutilation STMN4 DPYSL2 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders with a strong genetic etiology. Cytogenetic abnormalities have been detected in 5–10% of the patients with autism. In this study, we present the clinical, cytogenetic and array-comparative genomic hybridization (array-CGH) evaluation of a 13-year-old male with severe developmental delay, facial dysmorphic features, autism and self mutilation. The patient was found to carry a de novo duplication of chromosome region 8p21 of minimally 6.14 and maximally 6.58 Mb as ascertained by bacterial artificial chromosome (BAC)-based array-CGH. Hitherto, only a few patients with autism with cytogenetically visible duplications involving the chromosome 8p21 region have been described, but the extent of these duplications has not been determined at the molecular level. This represents the smallest rearrangement of chromosomal region 8p21 as yet found in a patient with autism. For 11 of the 36 genes with known functions located within this duplication clear transcription in the brain was found. Of those the STMN4 and DPYSL2 genes are the most likely candidate genes to be involved in neuronal development, and, if altered in gene-dosage, in the autistic phenotype of our patient. En ligne : http://dx.doi.org/10.1007/s10803-008-0627-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=684

Pivotal Response Treatment (PRT) - Parent Group Training for Young Children with Autism Spectrum Disorder: A Qualitative Study on Perspectives of Parents / Manon W. P. DE KORTE in Journal of Autism and Developmental Disorders, 52-12 (December 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5414-5427 Titre : Pivotal Response Treatment (PRT) - Parent Group Training for Young Children with Autism Spectrum Disorder: A Qualitative Study on Perspectives of Parents Type de document : Texte imprimé et/ou numérique Auteurs : Manon W. P. DE KORTE, Auteur ; Shireen P. T. KAIJADOE, Auteur ; Jan K. BUITELAAR, Auteur ; Wouter G. STAAL, Auteur ; Martine VAN DONGEN-BOOMSMA, Auteur Année de publication : 2022 Article en page(s) : p.5414-5427 Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/therapy  Parents/education  Qualitative Research  Social Skills  Communication  Autism spectrum disorder (ASD)  Parent group  Parent-mediated  Pivotal response treatment (PRT)  Young children  advisory board of/and/or speaker for Takeda/Shire, Roche, Medice, Janssen Cilag,  Angelini, and Servier. He is not an employee of any of these companies, and not a  stock shareholder of any of these companies. He has no other financial or  material support, including expert testimony, patents, royalties. All other  authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : Pivotal Response Treatment (PRT) is considered to be an empirically supported parent-mediated treatment for children with autism spectrum disorder (ASD), but research on parental experiences is lacking. This qualitative study examined the perspectives of parents of young children with ASD who participated in a 14-week PRT with parent group training (PRT-PG). Semi-structured interviews (n=12) were carried out, based on Grounded Theory principles. Results indicated that facilitators and barriers were related to timing and expectations, training setting and characteristics, and participant characteristics. Perceived effects were related to improved child's social-communication skills and well-being, parental insights into their child's needs and own habitual patterns in communication and behavior, and positive changes in family cohesion. The findings indicate that in general parents value PRT-PG as feasible and effective. En ligne : http://dx.doi.org/10.1007/s10803-021-05397-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Pivotal Response Treatment (PRT) - Parent Group Training for Young Children with Autism Spectrum Disorder: A Qualitative Study on Perspectives of Parents [Texte imprimé et/ou numérique] / Manon W. P. DE KORTE, Auteur ; Shireen P. T. KAIJADOE, Auteur ; Jan K. BUITELAAR, Auteur ; Wouter G. STAAL, Auteur ; Martine VAN DONGEN-BOOMSMA, Auteur . - 2022 . - p.5414-5427. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5414-5427 Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/therapy  Parents/education  Qualitative Research  Social Skills  Communication  Autism spectrum disorder (ASD)  Parent group  Parent-mediated  Pivotal response treatment (PRT)  Young children  advisory board of/and/or speaker for Takeda/Shire, Roche, Medice, Janssen Cilag,  Angelini, and Servier. He is not an employee of any of these companies, and not a  stock shareholder of any of these companies. He has no other financial or  material support, including expert testimony, patents, royalties. All other  authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : Pivotal Response Treatment (PRT) is considered to be an empirically supported parent-mediated treatment for children with autism spectrum disorder (ASD), but research on parental experiences is lacking. This qualitative study examined the perspectives of parents of young children with ASD who participated in a 14-week PRT with parent group training (PRT-PG). Semi-structured interviews (n=12) were carried out, based on Grounded Theory principles. Results indicated that facilitators and barriers were related to timing and expectations, training setting and characteristics, and participant characteristics. Perceived effects were related to improved child's social-communication skills and well-being, parental insights into their child's needs and own habitual patterns in communication and behavior, and positive changes in family cohesion. The findings indicate that in general parents value PRT-PG as feasible and effective. En ligne : http://dx.doi.org/10.1007/s10803-021-05397-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Self-regulation and quality of life in high-functioning young adults with autism / Renee R. DIJKHUIS in Autism, 21-7 (October 2017)  

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Stop and Change: Inhibition and Flexibility Skills Are Related to Repetitive Behavior in Children and Young Adults with Autism Spectrum Disorders / Mandy A. L. MOSTERT-KERCKHOFFS in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

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