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Auteur Meng-Chuan LAI |
Documents disponibles écrits par cet auteur (57)
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Neural self-representation in autistic women and association with 'compensatory camouflaging' / Meng-Chuan LAI in Autism, 23-5 (July 2019)
[article]
Titre : Neural self-representation in autistic women and association with 'compensatory camouflaging' Type de document : Texte imprimé et/ou numérique Auteurs : Meng-Chuan LAI, Auteur ; M. V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur ; A. N. RUIGROK, Auteur ; Edward T. BULLMORE, Auteur ; J. SUCKLING, Auteur ; Bonnie AUYEUNG, Auteur ; Francesca HAPPE, Auteur ; P. SZATMARI, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : p.1210-1223 Langues : Anglais (eng) Mots-clés : adult autism camouflaging compensation functional magnetic resonance imaging gender heterogeneity mentalizing self sex Index. décimale : PER Périodiques Résumé : Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neural sex/gender differences are related to behavioural sex/gender differences in autism. Here, we examined whether atypical neural responses during mentalizing and self-representation are sex/gender-dependent in autistic adults and explored whether 'camouflaging' (acting as if behaviourally neurotypical) is associated with sex/gender-dependent neural responses. In total, N = 119 adults (33 typically developing males, 29 autistic males, 29 typically developing females and 28 autistic females) participated in a task-related functional magnetic resonance imaging paradigm to assess neural activation within right temporo-parietal junction and ventromedial prefrontal cortex during mentalizing and self-representation. Camouflaging in autism was quantified as the discrepancy between extrinsic behaviour in social-interpersonal contexts and intrinsic status. While autistic men showed hypoactive right temporo-parietal junction mentalizing and ventromedial prefrontal cortex self-representation responses compared to typically developing men, such neural responses in autistic women were not different from typically developing women. In autistic women only, increasing camouflaging was associated with heightened ventromedial prefrontal cortex self-representation response. There is a lack of impaired neural self-representation and mentalizing in autistic women compared to typically developing women. Camouflaging is heightened in autistic women and may relate to neural self-representation response. These results reveal brain-behaviour relations that help explain sex/gender-heterogeneity in social brain function in autism. En ligne : http://dx.doi.org/10.1177/1362361318807159 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Autism > 23-5 (July 2019) . - p.1210-1223[article] Neural self-representation in autistic women and association with 'compensatory camouflaging' [Texte imprimé et/ou numérique] / Meng-Chuan LAI, Auteur ; M. V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur ; A. N. RUIGROK, Auteur ; Edward T. BULLMORE, Auteur ; J. SUCKLING, Auteur ; Bonnie AUYEUNG, Auteur ; Francesca HAPPE, Auteur ; P. SZATMARI, Auteur ; Simon BARON-COHEN, Auteur . - p.1210-1223.
Langues : Anglais (eng)
in Autism > 23-5 (July 2019) . - p.1210-1223
Mots-clés : adult autism camouflaging compensation functional magnetic resonance imaging gender heterogeneity mentalizing self sex Index. décimale : PER Périodiques Résumé : Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neural sex/gender differences are related to behavioural sex/gender differences in autism. Here, we examined whether atypical neural responses during mentalizing and self-representation are sex/gender-dependent in autistic adults and explored whether 'camouflaging' (acting as if behaviourally neurotypical) is associated with sex/gender-dependent neural responses. In total, N = 119 adults (33 typically developing males, 29 autistic males, 29 typically developing females and 28 autistic females) participated in a task-related functional magnetic resonance imaging paradigm to assess neural activation within right temporo-parietal junction and ventromedial prefrontal cortex during mentalizing and self-representation. Camouflaging in autism was quantified as the discrepancy between extrinsic behaviour in social-interpersonal contexts and intrinsic status. While autistic men showed hypoactive right temporo-parietal junction mentalizing and ventromedial prefrontal cortex self-representation responses compared to typically developing men, such neural responses in autistic women were not different from typically developing women. In autistic women only, increasing camouflaging was associated with heightened ventromedial prefrontal cortex self-representation response. There is a lack of impaired neural self-representation and mentalizing in autistic women compared to typically developing women. Camouflaging is heightened in autistic women and may relate to neural self-representation response. These results reveal brain-behaviour relations that help explain sex/gender-heterogeneity in social brain function in autism. En ligne : http://dx.doi.org/10.1177/1362361318807159 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 Physical health of autistic girls and women: a scoping review / Caroline KASSEE in Molecular Autism, 11 (2020)
[article]
Titre : Physical health of autistic girls and women: a scoping review Type de document : Texte imprimé et/ou numérique Auteurs : Caroline KASSEE, Auteur ; Stephanie BABINSKI, Auteur ; Ami TINT, Auteur ; Yona LUNSKY, Auteur ; Hilary K. BROWN, Auteur ; Stephanie H. AMEIS, Auteur ; Peter SZATMARI, Auteur ; Meng-Chuan LAI, Auteur ; Gillian EINSTEIN, Auteur Langues : Anglais (eng) Mots-clés : Autism Gender Girls Physical health Scoping review Sex differences Women Index. décimale : PER Périodiques Résumé : BACKGROUND: There is a growing recognition of sex and gender influences in autism. Increasingly, studies include comparisons between sexes or genders, but few have focused on clarifying the characteristics of autistic girls'/women's physical health. METHODS: A scoping review was conducted to determine what is currently known about the physical health of autistic girls/women. We screened 1112 unique articles, with 40 studies meeting the inclusion criteria. We used a convergent iterative process to synthesize this content into broad thematic areas. RESULTS: Autistic girls/women experience more overall physical health challenges compared to non-autistic girls/women and to autistic boys/men. Emerging evidence suggests increased prevalence of epilepsy in autistic girls/women compared to non-autistic girls/women and to autistic boys/men. The literature also suggests increased endocrine and reproductive health conditions in autistic girls/women compared to non-autistic girls/women. Findings regarding gastrointestinal, metabolic, nutritional, and immune-related conditions are preliminary and inconsistent. LIMITATIONS: The literature has substantial heterogeneity in how physical health conditions were assessed and reported. Further, our explicit focus on physical health may have constrained the ability to examine interactions between mental and physical health. The widely differing research aims and methodologies make it difficult to reach definitive conclusions. Nevertheless, in keeping with the goals of a scoping review, we were able to identify key themes to guide future research. CONCLUSIONS: The emerging literature suggests that autistic girls/women have heightened rates of physical health challenges compared to non-autistic girls/women and to autistic boys/men. Clinicians should seek to provide holistic care that includes a focus on physical health and develop a women's health lens when providing clinical care to autistic girls/women. En ligne : http://dx.doi.org/10.1186/s13229-020-00380-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Molecular Autism > 11 (2020)[article] Physical health of autistic girls and women: a scoping review [Texte imprimé et/ou numérique] / Caroline KASSEE, Auteur ; Stephanie BABINSKI, Auteur ; Ami TINT, Auteur ; Yona LUNSKY, Auteur ; Hilary K. BROWN, Auteur ; Stephanie H. AMEIS, Auteur ; Peter SZATMARI, Auteur ; Meng-Chuan LAI, Auteur ; Gillian EINSTEIN, Auteur.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020)
Mots-clés : Autism Gender Girls Physical health Scoping review Sex differences Women Index. décimale : PER Périodiques Résumé : BACKGROUND: There is a growing recognition of sex and gender influences in autism. Increasingly, studies include comparisons between sexes or genders, but few have focused on clarifying the characteristics of autistic girls'/women's physical health. METHODS: A scoping review was conducted to determine what is currently known about the physical health of autistic girls/women. We screened 1112 unique articles, with 40 studies meeting the inclusion criteria. We used a convergent iterative process to synthesize this content into broad thematic areas. RESULTS: Autistic girls/women experience more overall physical health challenges compared to non-autistic girls/women and to autistic boys/men. Emerging evidence suggests increased prevalence of epilepsy in autistic girls/women compared to non-autistic girls/women and to autistic boys/men. The literature also suggests increased endocrine and reproductive health conditions in autistic girls/women compared to non-autistic girls/women. Findings regarding gastrointestinal, metabolic, nutritional, and immune-related conditions are preliminary and inconsistent. LIMITATIONS: The literature has substantial heterogeneity in how physical health conditions were assessed and reported. Further, our explicit focus on physical health may have constrained the ability to examine interactions between mental and physical health. The widely differing research aims and methodologies make it difficult to reach definitive conclusions. Nevertheless, in keeping with the goals of a scoping review, we were able to identify key themes to guide future research. CONCLUSIONS: The emerging literature suggests that autistic girls/women have heightened rates of physical health challenges compared to non-autistic girls/women and to autistic boys/men. Clinicians should seek to provide holistic care that includes a focus on physical health and develop a women's health lens when providing clinical care to autistic girls/women. En ligne : http://dx.doi.org/10.1186/s13229-020-00380-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis / R. RODRIGUES in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)
[article]
Titre : Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : R. RODRIGUES, Auteur ; Meng-Chuan LAI, Auteur ; A. BESWICK, Auteur ; D. A. GORMAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; P. SZATMARI, Auteur ; K. K. ANDERSON, Auteur ; Stephanie H. AMEIS, Auteur Article en page(s) : p.680-700 Langues : Anglais (eng) Mots-clés : Adolescent Atomoxetine Hydrochloride/therapeutic use Attention Deficit Disorder with Hyperactivity/drug therapy Autism Spectrum Disorder/drug therapy Central Nervous System Stimulants/adverse effects Child Guanfacine Humans Methylphenidate/adverse effects Adhd Attention-deficit/hyperactivity disorder alpha-2 agonists antipsychotics atomoxetine autism spectrum disorder bupropion hyperactivity impulsivity inattention modafinil. pervasive developmental disorder pharmacotherapy stimulants tricyclic antidepressants venlafaxine Index. décimale : PER Périodiques Résumé : BACKGROUND: Clinically significant attention-deficit/hyperactivity disorder (ADHD) symptoms are common and impairing in children and youth with autism spectrum disorder(ASD). The aim of this systematic review and meta-analysis was to (a) evaluate the efficacy and safety of pharmacotherapy for the treatment of ADHD symptoms in ASD and (b) distil findings for clinical translation. METHODS: We searched electronic databases and clinical trial registries (1992 onwards). We selected randomized controlled trials conducted in participants <25 years of age, diagnosed with ASD that evaluated ADHD outcomes (hyperactivity/impulsivity and inattention) following treatment with stimulants (methylphenidate or amphetamines), atomoxetine, alpha-2 adrenergic receptor agonists, antipsychotics, tricyclic antidepressants, bupropion, modafinil, venlafaxine, or a combination, in comparison with placebo, any of the listed medications, or behavioral therapies. Data were pooled using a random-effects model. RESULTS: Twenty-five studies (4 methylphenidate, 4 atomoxetine, 1 guanfacine, 14 antipsychotic, 1 venlafaxine, and 1 tianeptine) were included. Methylphenidate reduced hyperactivity (parent-rated: standardized mean difference [SMD] = -.63, 95%CI = -.95,-.30; teacher-rated: SMD = -.81, 95%CI = -1.43,-.19) and inattention (parent-rated: SMD = -.36, 95%CI = -.64,-.07; teacher-rated: SMD = -.30, 95%CI = -.49,-.11). Atomoxetine reduced inattention (parent-rated: SMD = -.54, 95%CI = -.98,-.09; teacher/investigator-rated: SMD = -0.38, 95%CI = -0.75, -0.01) and parent-rated hyperactivity (parent-rated: SMD = -.49, 95%CI = -.76,-.23; teacher-rated: SMD = -.43, 95%CI = -.92, .06). Indirect evidence for significant reductions in hyperactivity with second-generation antipsychotics was also found. Quality of evidence for all interventions was low/very low. Methylphenidate was associated with a nonsignificant elevated risk of dropout due to adverse events. CONCLUSIONS: Direct pooled evidence supports the efficacy and tolerability of methylphenidate or atomoxetine for treatment of ADHD symptoms in children and youth with ASD. The current review highlights the efficacy of standard ADHD pharmacotherapy for treatment of ADHD symptoms in children and youth with ASD. Consideration of the benefits weighed against the limitations of safety/efficacy data and lack of data evaluating long-term continuation is undertaken to help guide clinical decision-making regarding treatment of co-occurring ADHD symptoms in children and youth with ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13305 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.680-700[article] Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis [Texte imprimé et/ou numérique] / R. RODRIGUES, Auteur ; Meng-Chuan LAI, Auteur ; A. BESWICK, Auteur ; D. A. GORMAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; P. SZATMARI, Auteur ; K. K. ANDERSON, Auteur ; Stephanie H. AMEIS, Auteur . - p.680-700.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.680-700
Mots-clés : Adolescent Atomoxetine Hydrochloride/therapeutic use Attention Deficit Disorder with Hyperactivity/drug therapy Autism Spectrum Disorder/drug therapy Central Nervous System Stimulants/adverse effects Child Guanfacine Humans Methylphenidate/adverse effects Adhd Attention-deficit/hyperactivity disorder alpha-2 agonists antipsychotics atomoxetine autism spectrum disorder bupropion hyperactivity impulsivity inattention modafinil. pervasive developmental disorder pharmacotherapy stimulants tricyclic antidepressants venlafaxine Index. décimale : PER Périodiques Résumé : BACKGROUND: Clinically significant attention-deficit/hyperactivity disorder (ADHD) symptoms are common and impairing in children and youth with autism spectrum disorder(ASD). The aim of this systematic review and meta-analysis was to (a) evaluate the efficacy and safety of pharmacotherapy for the treatment of ADHD symptoms in ASD and (b) distil findings for clinical translation. METHODS: We searched electronic databases and clinical trial registries (1992 onwards). We selected randomized controlled trials conducted in participants <25 years of age, diagnosed with ASD that evaluated ADHD outcomes (hyperactivity/impulsivity and inattention) following treatment with stimulants (methylphenidate or amphetamines), atomoxetine, alpha-2 adrenergic receptor agonists, antipsychotics, tricyclic antidepressants, bupropion, modafinil, venlafaxine, or a combination, in comparison with placebo, any of the listed medications, or behavioral therapies. Data were pooled using a random-effects model. RESULTS: Twenty-five studies (4 methylphenidate, 4 atomoxetine, 1 guanfacine, 14 antipsychotic, 1 venlafaxine, and 1 tianeptine) were included. Methylphenidate reduced hyperactivity (parent-rated: standardized mean difference [SMD] = -.63, 95%CI = -.95,-.30; teacher-rated: SMD = -.81, 95%CI = -1.43,-.19) and inattention (parent-rated: SMD = -.36, 95%CI = -.64,-.07; teacher-rated: SMD = -.30, 95%CI = -.49,-.11). Atomoxetine reduced inattention (parent-rated: SMD = -.54, 95%CI = -.98,-.09; teacher/investigator-rated: SMD = -0.38, 95%CI = -0.75, -0.01) and parent-rated hyperactivity (parent-rated: SMD = -.49, 95%CI = -.76,-.23; teacher-rated: SMD = -.43, 95%CI = -.92, .06). Indirect evidence for significant reductions in hyperactivity with second-generation antipsychotics was also found. Quality of evidence for all interventions was low/very low. Methylphenidate was associated with a nonsignificant elevated risk of dropout due to adverse events. CONCLUSIONS: Direct pooled evidence supports the efficacy and tolerability of methylphenidate or atomoxetine for treatment of ADHD symptoms in children and youth with ASD. The current review highlights the efficacy of standard ADHD pharmacotherapy for treatment of ADHD symptoms in children and youth with ASD. Consideration of the benefits weighed against the limitations of safety/efficacy data and lack of data evaluating long-term continuation is undertaken to help guide clinical decision-making regarding treatment of co-occurring ADHD symptoms in children and youth with ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13305 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Premature mortality in a population-based cohort of autistic adults in Canada / Yona LUNSKY in Autism Research, 15-8 (August 2022)
[article]
Titre : Premature mortality in a population-based cohort of autistic adults in Canada Type de document : Texte imprimé et/ou numérique Auteurs : Yona LUNSKY, Auteur ; Meng-Chuan LAI, Auteur ; Robert BALOGH, Auteur ; Hannah CHUNG, Auteur ; Anna DURBIN, Auteur ; Patrick JACHYRA, Auteur ; Ami TINT, Auteur ; Jonathan WEISS, Auteur ; Elizabeth LIN, Auteur Article en page(s) : p.1550-1559 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/epidemiology Autistic Disorder/epidemiology Child Cohort Studies Developmental Disabilities/epidemiology Female Humans Infant, Newborn Male Mortality, Premature Ontario/epidemiology autism developmental disabilities premature mortality sex differences Index. décimale : PER Périodiques Résumé : Research from different countries suggests that autistic adults are more likely to die prematurely than non-autistic adults, but these studies do not always investigate male and female individuals separately and do not consider whether this pattern is unique to autistic people or is also an issue for people with other developmental disabilities. We examined premature mortality in autistic males and females (assigned at birth) in a population-based cohort, compared to males and females with and without other developmental disabilities. Using linked administrative health and social services population data from Ontario, Canada, age-matched males and females aged 19-65years were followed between 2010 and 2016, and causes of death were determined. Over the 6-year observation period, 330 of 42,607 persons (0.77%) in the group without developmental disabilities had died compared to 259 of 10,646 persons (2.43%) in the autism group and 419 of 10,615 persons (3.95%) in the other developmental disabilities group. Autistic males and females were more likely to die than non-autistic males (adjusted risk ratio, RR 3.13, 95%CI 2.58-3.79) and non-autistic females (adjusted RR 3.12, 95%CI 2.35-4.13) without developmental disabilities, but were less likely to die than adults with other developmental disabilities (males: adjusted RR 0.66, 95%CI 0.55-0.79; females: adjusted RR 0.55, 95%CI 0.43-0.71). Most common causes of death varied depending on a person's sex and diagnosis. Given the greater likelihood of premature mortality in adults with developmental disabilities including autism, greater attention and resources directed toward their health and social care are needed, tailored to their sex and diagnosis-informed needs. LAY SUMMARY: This study looked at how many autistic men and women died over 6years (2010-2016), along with how they died, and compared this to adults who did not have autism living in Ontario, Canada. It found that autistic men and women were more than three times as likely to die as people of the same age who did not have a developmental disability. However, adults with other developmental disabilities besides autism were even more likely to die than autistic adults. This means that we have to pay more attention and invest in better social and health care for autistic people, along with people who have other types of developmental disabilities. En ligne : http://dx.doi.org/10.1002/aur.2741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483
in Autism Research > 15-8 (August 2022) . - p.1550-1559[article] Premature mortality in a population-based cohort of autistic adults in Canada [Texte imprimé et/ou numérique] / Yona LUNSKY, Auteur ; Meng-Chuan LAI, Auteur ; Robert BALOGH, Auteur ; Hannah CHUNG, Auteur ; Anna DURBIN, Auteur ; Patrick JACHYRA, Auteur ; Ami TINT, Auteur ; Jonathan WEISS, Auteur ; Elizabeth LIN, Auteur . - p.1550-1559.
Langues : Anglais (eng)
in Autism Research > 15-8 (August 2022) . - p.1550-1559
Mots-clés : Adult Autism Spectrum Disorder/epidemiology Autistic Disorder/epidemiology Child Cohort Studies Developmental Disabilities/epidemiology Female Humans Infant, Newborn Male Mortality, Premature Ontario/epidemiology autism developmental disabilities premature mortality sex differences Index. décimale : PER Périodiques Résumé : Research from different countries suggests that autistic adults are more likely to die prematurely than non-autistic adults, but these studies do not always investigate male and female individuals separately and do not consider whether this pattern is unique to autistic people or is also an issue for people with other developmental disabilities. We examined premature mortality in autistic males and females (assigned at birth) in a population-based cohort, compared to males and females with and without other developmental disabilities. Using linked administrative health and social services population data from Ontario, Canada, age-matched males and females aged 19-65years were followed between 2010 and 2016, and causes of death were determined. Over the 6-year observation period, 330 of 42,607 persons (0.77%) in the group without developmental disabilities had died compared to 259 of 10,646 persons (2.43%) in the autism group and 419 of 10,615 persons (3.95%) in the other developmental disabilities group. Autistic males and females were more likely to die than non-autistic males (adjusted risk ratio, RR 3.13, 95%CI 2.58-3.79) and non-autistic females (adjusted RR 3.12, 95%CI 2.35-4.13) without developmental disabilities, but were less likely to die than adults with other developmental disabilities (males: adjusted RR 0.66, 95%CI 0.55-0.79; females: adjusted RR 0.55, 95%CI 0.43-0.71). Most common causes of death varied depending on a person's sex and diagnosis. Given the greater likelihood of premature mortality in adults with developmental disabilities including autism, greater attention and resources directed toward their health and social care are needed, tailored to their sex and diagnosis-informed needs. LAY SUMMARY: This study looked at how many autistic men and women died over 6years (2010-2016), along with how they died, and compared this to adults who did not have autism living in Ontario, Canada. It found that autistic men and women were more than three times as likely to die as people of the same age who did not have a developmental disability. However, adults with other developmental disabilities besides autism were even more likely to die than autistic adults. This means that we have to pay more attention and invest in better social and health care for autistic people, along with people who have other types of developmental disabilities. En ligne : http://dx.doi.org/10.1002/aur.2741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 Psychometric properties of the Chinese version of the Social Communication Questionnaire / Susan Shur-Fen GAU in Research in Autism Spectrum Disorders, 5-2 (April-June 2011)
[article]
Titre : Psychometric properties of the Chinese version of the Social Communication Questionnaire Type de document : Texte imprimé et/ou numérique Auteurs : Susan Shur-Fen GAU, Auteur ; Chi-Mei LEE, Auteur ; Meng-Chuan LAI, Auteur ; Yen-Nan CHIU, Auteur ; Ya-Fen HUANG, Auteur ; Jen-Der KAO, Auteur ; Yu-Yu WU, Auteur Année de publication : 2011 Article en page(s) : p.809-818 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study aimed to examine the psychometric properties of the Chinese version of the Social Communication Questionnaire (SCQ). We assessed 736 participants (male, 80.1%) aged 2–18, who were clinically diagnosed with autism spectrum disorders (ASD) including autistic disorder, Asperger's disorder, or pervasive developmental disorders, not otherwise specified according to the DSM-IV diagnostic criteria. All the parents completed the Chinese versions of the SCQ. Among them, parents of 317 participants were interviewed by using the Chinese version of the Autism Diagnostic Interview-Revised (ADI-R). The exploratory factor analysis revealed a three-factor structure (social interaction, repetitive behaviors, and communication), which was further validated by the confirmatory factor analyses with an adequate fit (Goodness-of-Fit Index = 0.923; Comparative Fit Index = 0.983; root mean square error of approximation = 0.034). The test–retest reliability (intra-class correlations = 0.77–0.78), internal consistency (α = 0.73–0.91), and concurrent validity (Pearson correlation up to 0.65) were satisfactory. Children with autistic disorder had the highest scores, followed by children with Asperger's disorder who had intermediate scores and then non-ASD participants who had the lowest scores. Our findings suggest that the Chinese SCQ is a reliable and valid instrument for rating autistic symptoms in Chinese-speaking population (ClinicalTrials.gov number: NCT00494754). En ligne : http://dx.doi.org/10.1016/j.rasd.2010.09.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Research in Autism Spectrum Disorders > 5-2 (April-June 2011) . - p.809-818[article] Psychometric properties of the Chinese version of the Social Communication Questionnaire [Texte imprimé et/ou numérique] / Susan Shur-Fen GAU, Auteur ; Chi-Mei LEE, Auteur ; Meng-Chuan LAI, Auteur ; Yen-Nan CHIU, Auteur ; Ya-Fen HUANG, Auteur ; Jen-Der KAO, Auteur ; Yu-Yu WU, Auteur . - 2011 . - p.809-818.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 5-2 (April-June 2011) . - p.809-818
Index. décimale : PER Périodiques Résumé : This study aimed to examine the psychometric properties of the Chinese version of the Social Communication Questionnaire (SCQ). We assessed 736 participants (male, 80.1%) aged 2–18, who were clinically diagnosed with autism spectrum disorders (ASD) including autistic disorder, Asperger's disorder, or pervasive developmental disorders, not otherwise specified according to the DSM-IV diagnostic criteria. All the parents completed the Chinese versions of the SCQ. Among them, parents of 317 participants were interviewed by using the Chinese version of the Autism Diagnostic Interview-Revised (ADI-R). The exploratory factor analysis revealed a three-factor structure (social interaction, repetitive behaviors, and communication), which was further validated by the confirmatory factor analyses with an adequate fit (Goodness-of-Fit Index = 0.923; Comparative Fit Index = 0.983; root mean square error of approximation = 0.034). The test–retest reliability (intra-class correlations = 0.77–0.78), internal consistency (α = 0.73–0.91), and concurrent validity (Pearson correlation up to 0.65) were satisfactory. Children with autistic disorder had the highest scores, followed by children with Asperger's disorder who had intermediate scores and then non-ASD participants who had the lowest scores. Our findings suggest that the Chinese SCQ is a reliable and valid instrument for rating autistic symptoms in Chinese-speaking population (ClinicalTrials.gov number: NCT00494754). En ligne : http://dx.doi.org/10.1016/j.rasd.2010.09.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Publishing standards for promoting excellence in autism research / Sue FLETCHER-WATSON in Autism, 25-6 (August 2021)
PermalinkPublishing standards for promoting excellence in autism research / Sue FLETCHER-WATSON in Autism, 26-6 (August 2022)
Permalink“Putting on My Best Normal”: Social Camouflaging in Adults with Autism Spectrum Conditions / Laura HULL in Journal of Autism and Developmental Disorders, 47-8 (August 2017)
PermalinkQuantifying and exploring camouflaging in men and women with autism / Meng-Chuan LAI in Autism, 21-6 (August 2017)
PermalinkRecognition of Girls on the Autism Spectrum by Primary School Educators: An Experimental Study / Alana WHITLOCK in Autism Research, 13-8 (August 2020)
PermalinkRegional brain volume differences between males with and without autism spectrum disorder are highly age-dependent / Hsiang-Yuan LIN in Molecular Autism, (May 2015)
PermalinkPermalinkRethinking autism spectrum disorder assessment for children during COVID-19 and beyond / Lonnie ZWAIGENBAUM in Autism Research, 14-11 (November 2021)
Permalink"Revêtir ma meilleure panoplie de normalité" : camouflage social chez les adultes présentant une condition du spectre autistique / L. HULL in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 150 (Novembre/Décembre 2017)
PermalinkRigor in science and science reporting: updated guidelines for submissions to Molecular Autism / Joseph D. BUXBAUM in Molecular Autism, 10 (2019)
Permalink