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Auteur A. PICKLES |
Documents disponibles écrits par cet auteur (19)
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Synergy between callous–unemotional traits and aggression in preschool children: Cross-informant and cross-cultural replication in the UK Wirral Child Health and Development Study, and the Colombian La Sabana Parent–Child Study / D. OBANDO in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Synergy between callous–unemotional traits and aggression in preschool children: Cross-informant and cross-cultural replication in the UK Wirral Child Health and Development Study, and the Colombian La Sabana Parent–Child Study Type de document : Texte imprimé et/ou numérique Auteurs : D. OBANDO, Auteur ; J. HILL, Auteur ; H. SHARP, Auteur ; A. PICKLES, Auteur ; L. FISHER, Auteur ; N. WRIGHT, Auteur Article en page(s) : p.1079-1087 Langues : Anglais (eng) Mots-clés : aggression callous–unemotional traits cross-cultural cross-informant preschool Index. décimale : PER Périodiques Résumé : Incremental prediction of aggression from callous “unemotional (CU) traits is well established, but cross-cultural replication and studies of young children are needed. Little is understood about the contribution of CU traits in children who are already aggressive. We addressed these issues in prospective studies in the United Kingdom and Colombia. In a UK epidemiological cohort, CU traits and aggression were assessed at age 3.5 years, and aggression at 5.0 years by mothers (N = 687) and partners (N = 397). In a Colombian general population sample, CU traits were assessed at age 3.5 years and aggression at 3.5 and 5.0 years by mother report (N = 220). Analyses consistently showed prediction of age-5.0 aggression by age-3.5 CU traits controlling for age-3.5 aggression. Associations between age-3.5 CU traits and age-5.0 aggression were moderated by aggression at 3.5 years, with UK interaction terms, same informant,Î2 = .07 p = .014 cross-informant,Î2 = .14 p = .002, and in Colombia,Î2 = .09 p = .128. The interactions arose from stronger associations between CU traits and later aggression in those already aggressive. Our findings with preschoolers replicated across culturally diverse settings imply a major role for CU traits in the maintenance and amplification of already established aggression, and cast doubt on their contribution to its origins. En ligne : http://dx.doi.org/10.1017/S0954579420002114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Development and Psychopathology > 34-3 (August 2022) . - p.1079-1087[article] Synergy between callous–unemotional traits and aggression in preschool children: Cross-informant and cross-cultural replication in the UK Wirral Child Health and Development Study, and the Colombian La Sabana Parent–Child Study [Texte imprimé et/ou numérique] / D. OBANDO, Auteur ; J. HILL, Auteur ; H. SHARP, Auteur ; A. PICKLES, Auteur ; L. FISHER, Auteur ; N. WRIGHT, Auteur . - p.1079-1087.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.1079-1087
Mots-clés : aggression callous–unemotional traits cross-cultural cross-informant preschool Index. décimale : PER Périodiques Résumé : Incremental prediction of aggression from callous “unemotional (CU) traits is well established, but cross-cultural replication and studies of young children are needed. Little is understood about the contribution of CU traits in children who are already aggressive. We addressed these issues in prospective studies in the United Kingdom and Colombia. In a UK epidemiological cohort, CU traits and aggression were assessed at age 3.5 years, and aggression at 5.0 years by mothers (N = 687) and partners (N = 397). In a Colombian general population sample, CU traits were assessed at age 3.5 years and aggression at 3.5 and 5.0 years by mother report (N = 220). Analyses consistently showed prediction of age-5.0 aggression by age-3.5 CU traits controlling for age-3.5 aggression. Associations between age-3.5 CU traits and age-5.0 aggression were moderated by aggression at 3.5 years, with UK interaction terms, same informant,Î2 = .07 p = .014 cross-informant,Î2 = .14 p = .002, and in Colombia,Î2 = .09 p = .128. The interactions arose from stronger associations between CU traits and later aggression in those already aggressive. Our findings with preschoolers replicated across culturally diverse settings imply a major role for CU traits in the maintenance and amplification of already established aggression, and cast doubt on their contribution to its origins. En ligne : http://dx.doi.org/10.1017/S0954579420002114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 The Association Between Child and Family Characteristics and the Mental Health and Wellbeing of Caregivers of Children with Autism in Mid-Childhood / E. SALOMONE in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
[article]
Titre : The Association Between Child and Family Characteristics and the Mental Health and Wellbeing of Caregivers of Children with Autism in Mid-Childhood Type de document : Texte imprimé et/ou numérique Auteurs : E. SALOMONE, Auteur ; K. LEADBITTER, Auteur ; Catherine ALDRED, Auteur ; B. BARRETT, Auteur ; Sarah BYFORD, Auteur ; Tony CHARMAN, Auteur ; P. HOWLIN, Auteur ; J. GREEN, Auteur ; A. LE COUTEUR, Auteur ; H. MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur ; A. PICKLES, Auteur ; V. SLONIMS, Auteur Article en page(s) : p.1189-1198 Langues : Anglais (eng) Mots-clés : Autism Caregiver Daily living skills Emotional and behavioural difficulties Mental health Mental wellbeing Index. décimale : PER Périodiques Résumé : We examined predictors of mental health difficulties and wellbeing in caregivers of children with autism in the Pre-school Autism Communication Trial cohort in middle childhood (N = 104). Child's intellectual disability, daily living skills impairment, elevated emotional and behavioural difficulties, high educational level of caregiver and household income below the median significantly predicted caregivers' mental health difficulties, but autism severity, child communication skills and family circumstances did not. Lower caregiver mental wellbeing was predicted by elevated child emotional and behavioural difficulties. The need to support the mental health and wellbeing of caregivers of children with autism is discussed in light of the results. En ligne : http://dx.doi.org/10.1007/s10803-017-3392-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1189-1198[article] The Association Between Child and Family Characteristics and the Mental Health and Wellbeing of Caregivers of Children with Autism in Mid-Childhood [Texte imprimé et/ou numérique] / E. SALOMONE, Auteur ; K. LEADBITTER, Auteur ; Catherine ALDRED, Auteur ; B. BARRETT, Auteur ; Sarah BYFORD, Auteur ; Tony CHARMAN, Auteur ; P. HOWLIN, Auteur ; J. GREEN, Auteur ; A. LE COUTEUR, Auteur ; H. MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur ; A. PICKLES, Auteur ; V. SLONIMS, Auteur . - p.1189-1198.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1189-1198
Mots-clés : Autism Caregiver Daily living skills Emotional and behavioural difficulties Mental health Mental wellbeing Index. décimale : PER Périodiques Résumé : We examined predictors of mental health difficulties and wellbeing in caregivers of children with autism in the Pre-school Autism Communication Trial cohort in middle childhood (N = 104). Child's intellectual disability, daily living skills impairment, elevated emotional and behavioural difficulties, high educational level of caregiver and household income below the median significantly predicted caregivers' mental health difficulties, but autism severity, child communication skills and family circumstances did not. Lower caregiver mental wellbeing was predicted by elevated child emotional and behavioural difficulties. The need to support the mental health and wellbeing of caregivers of children with autism is discussed in light of the results. En ligne : http://dx.doi.org/10.1007/s10803-017-3392-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 The association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder / M. J. HOLLOCKS in Autism Research, 14-8 (August 2021)
[article]
Titre : The association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. J. HOLLOCKS, Auteur ; R. MEISER-STEDMAN, Auteur ; R. KENT, Auteur ; S. LUKITO, Auteur ; Jackie BRISKMAN, Auteur ; D. STRINGER, Auteur ; C. LORD, Auteur ; A. PICKLES, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; E. SIMONOFF, Auteur Article en page(s) : p.1724-1735 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/complications Child Emotions Humans Longitudinal Studies Mental Health Parents Young Adult anxiety co-morbid conditions depression environmental risk factors stress Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) are at increased risk of developing co-occurring mental health difficulties across the lifespan. Exposure to adverse life events and parental mental health difficulties are known risk factors for developing a range of mental health difficulties. This study investigates the association of adverse life events, parental stress and mental health with emotional and behavioral problems in young adults with ASD. One hundred and fifteen young adults with ASD derived from a population-based longitudinal study were assessed at three time-points (12-, 16-, and 23-year) on questionnaire measures of emotional and behavioral problems. Parent-reported exposure to adverse life events and parental stress/mental health were measured at age 23. We used structural equation modeling to investigate the stability of emotional and behavioral problems over time, and the association between adverse life events and parental stress and mental health and emotional and behavioral outcomes at 23-year. Our results indicate that exposure to adverse life events was significantly associated with increased emotional and behavioral problems in young adults with ASD, while controlling for symptoms in childhood and adolescence. Higher reported parental stress and mental health difficulties were associated with a higher frequency of behavioral, but not emotional problems, and did not mediate the impact of adverse life events. These results suggest that child and adolescent emotional and behavioral problems, exposure to life events and parent stress and mental health are independently associated, to differing degrees, with emotional or behavioral outcomes in early adulthood. LAY SUMMARY: People with autism experience high rates of mental health difficulties throughout childhood and into adult life. Adverse life events and parental stress and mental health may contribute to poor mental health in adulthood. We used data at three time points (12-, 16-, and 23-year) to understand how these factors relate to symptoms at 23-year. We found that emotional and behavioral problems in childhood, adverse life events and parent mental health were all associated with increased emotional and behavioral problems in adulthood. En ligne : http://dx.doi.org/10.1002/aur.2548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1724-1735[article] The association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder [Texte imprimé et/ou numérique] / M. J. HOLLOCKS, Auteur ; R. MEISER-STEDMAN, Auteur ; R. KENT, Auteur ; S. LUKITO, Auteur ; Jackie BRISKMAN, Auteur ; D. STRINGER, Auteur ; C. LORD, Auteur ; A. PICKLES, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; E. SIMONOFF, Auteur . - p.1724-1735.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1724-1735
Mots-clés : Adolescent Adult Autism Spectrum Disorder/complications Child Emotions Humans Longitudinal Studies Mental Health Parents Young Adult anxiety co-morbid conditions depression environmental risk factors stress Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) are at increased risk of developing co-occurring mental health difficulties across the lifespan. Exposure to adverse life events and parental mental health difficulties are known risk factors for developing a range of mental health difficulties. This study investigates the association of adverse life events, parental stress and mental health with emotional and behavioral problems in young adults with ASD. One hundred and fifteen young adults with ASD derived from a population-based longitudinal study were assessed at three time-points (12-, 16-, and 23-year) on questionnaire measures of emotional and behavioral problems. Parent-reported exposure to adverse life events and parental stress/mental health were measured at age 23. We used structural equation modeling to investigate the stability of emotional and behavioral problems over time, and the association between adverse life events and parental stress and mental health and emotional and behavioral outcomes at 23-year. Our results indicate that exposure to adverse life events was significantly associated with increased emotional and behavioral problems in young adults with ASD, while controlling for symptoms in childhood and adolescence. Higher reported parental stress and mental health difficulties were associated with a higher frequency of behavioral, but not emotional problems, and did not mediate the impact of adverse life events. These results suggest that child and adolescent emotional and behavioral problems, exposure to life events and parent stress and mental health are independently associated, to differing degrees, with emotional or behavioral outcomes in early adulthood. LAY SUMMARY: People with autism experience high rates of mental health difficulties throughout childhood and into adult life. Adverse life events and parental stress and mental health may contribute to poor mental health in adulthood. We used data at three time points (12-, 16-, and 23-year) to understand how these factors relate to symptoms at 23-year. We found that emotional and behavioral problems in childhood, adverse life events and parent mental health were all associated with increased emotional and behavioral problems in adulthood. En ligne : http://dx.doi.org/10.1002/aur.2548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 The subcortical correlates of autistic traits in school-age children: a population-based neuroimaging study / M. ELSABBAGH ; A. PICKLES ; R. BEDFORD in Molecular Autism, 14 (2023)
[article]
Titre : The subcortical correlates of autistic traits in school-age children: a population-based neuroimaging study Type de document : Texte imprimé et/ou numérique Auteurs : M. ELSABBAGH, Auteur ; A. PICKLES, Auteur ; R. BEDFORD, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: There is emerging evidence that the neuroanatomy of autism forms a spectrum which extends into the general population. However, whilst several studies have identified cortical morphology correlates of autistic traits, it is not established whether morphological differences are present in the subcortical structures of the brain. Additionally, it is not clear to what extent previously reported structural associations may be confounded by co-occurring psychopathology. To address these questions, we utilised neuroimaging data from the Adolescent Brain Cognitive Development Study to assess whether a measure of autistic traits was associated with differences in child subcortical morphology, and if any observed differences persisted after adjustment for child internalising and externalising symptoms. METHODS: Our analyses included data from 7005 children aged 9-10 years (female: 47.19%) participating in the Adolescent Brain Cognitive Development Study. Autistic traits were assessed using scores from the Social Responsiveness Scale (SRS). Volumes of subcortical regions of interest were derived from structural magnetic resonance imaging data. RESULTS: Overall, we did not find strong evidence for an association of autistic traits with differences in subcortical morphology in this sample of school-aged children. Whilst lower absolute volumes of the nucleus accumbens and putamen were associated with higher scores of autistic traits, these differences did not persist once a global measure of brain size was accounted for. LIMITATIONS: It is important to note that autistic traits were assessed using the SRS, of which higher scores are associated with general behavioural problems, and therefore may not be wholly indicative of autism-specific symptoms. In addition, individuals with a moderate or severe autism diagnosis were excluded from the ABCD study, and thus, the average level of autistic traits will be lower than in the general population which may bias findings towards the null. CONCLUSIONS: These findings from our well-powered study suggest that other metrics of brain morphology, such as cortical morphology or shape-based phenotypes, may be stronger candidates to prioritise when attempting to identify robust neuromarkers of autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-023-00538-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Molecular Autism > 14 (2023) . - 6 p.[article] The subcortical correlates of autistic traits in school-age children: a population-based neuroimaging study [Texte imprimé et/ou numérique] / M. ELSABBAGH, Auteur ; A. PICKLES, Auteur ; R. BEDFORD, Auteur . - 6 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 6 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND: There is emerging evidence that the neuroanatomy of autism forms a spectrum which extends into the general population. However, whilst several studies have identified cortical morphology correlates of autistic traits, it is not established whether morphological differences are present in the subcortical structures of the brain. Additionally, it is not clear to what extent previously reported structural associations may be confounded by co-occurring psychopathology. To address these questions, we utilised neuroimaging data from the Adolescent Brain Cognitive Development Study to assess whether a measure of autistic traits was associated with differences in child subcortical morphology, and if any observed differences persisted after adjustment for child internalising and externalising symptoms. METHODS: Our analyses included data from 7005 children aged 9-10 years (female: 47.19%) participating in the Adolescent Brain Cognitive Development Study. Autistic traits were assessed using scores from the Social Responsiveness Scale (SRS). Volumes of subcortical regions of interest were derived from structural magnetic resonance imaging data. RESULTS: Overall, we did not find strong evidence for an association of autistic traits with differences in subcortical morphology in this sample of school-aged children. Whilst lower absolute volumes of the nucleus accumbens and putamen were associated with higher scores of autistic traits, these differences did not persist once a global measure of brain size was accounted for. LIMITATIONS: It is important to note that autistic traits were assessed using the SRS, of which higher scores are associated with general behavioural problems, and therefore may not be wholly indicative of autism-specific symptoms. In addition, individuals with a moderate or severe autism diagnosis were excluded from the ABCD study, and thus, the average level of autistic traits will be lower than in the general population which may bias findings towards the null. CONCLUSIONS: These findings from our well-powered study suggest that other metrics of brain morphology, such as cortical morphology or shape-based phenotypes, may be stronger candidates to prioritise when attempting to identify robust neuromarkers of autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-023-00538-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513