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Responding to Other People's Direct Gaze: Alterations in Gaze Behavior in Infants at Risk for Autism Occur on Very Short Timescales / P. NYSTROM in Journal of Autism and Developmental Disorders, 47-11 (November 2017)
[article]
Titre : Responding to Other People's Direct Gaze: Alterations in Gaze Behavior in Infants at Risk for Autism Occur on Very Short Timescales Type de document : Texte imprimé et/ou numérique Auteurs : P. NYSTROM, Auteur ; Sven BÖLTE, Auteur ; T. FALCK-YTTER, Auteur Article en page(s) : p.3498-3509 Langues : Anglais (eng) Mots-clés : Autism Eye tracking Neurodevelopmental disorders Risk assessment Sensorimotor development Index. décimale : PER Périodiques Résumé : Atypical gaze processing has been reported in children with autism spectrum disorders (ASD). Here we explored how infants at risk for ASD respond behaviorally to others' direct gaze. We assessed 10-month-olds with a sibling with ASD (high risk group; n = 61) and a control group (n = 18) during interaction with an adult. Eye-tracking revealed less looking at the adult in the high risk group during 300-1000 ms after the adult initiated direct gaze: a short alteration that is likely to go unnoticed by the naked eye. Data aggregated over longer segments (the traditional eye-tracking approach) showed no group differences. Although findings are limited by lack of outcome data, they are in line with theories linking atypical eye processing to the emergence of ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3253-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3498-3509[article] Responding to Other People's Direct Gaze: Alterations in Gaze Behavior in Infants at Risk for Autism Occur on Very Short Timescales [Texte imprimé et/ou numérique] / P. NYSTROM, Auteur ; Sven BÖLTE, Auteur ; T. FALCK-YTTER, Auteur . - p.3498-3509.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3498-3509
Mots-clés : Autism Eye tracking Neurodevelopmental disorders Risk assessment Sensorimotor development Index. décimale : PER Périodiques Résumé : Atypical gaze processing has been reported in children with autism spectrum disorders (ASD). Here we explored how infants at risk for ASD respond behaviorally to others' direct gaze. We assessed 10-month-olds with a sibling with ASD (high risk group; n = 61) and a control group (n = 18) during interaction with an adult. Eye-tracking revealed less looking at the adult in the high risk group during 300-1000 ms after the adult initiated direct gaze: a short alteration that is likely to go unnoticed by the naked eye. Data aggregated over longer segments (the traditional eye-tracking approach) showed no group differences. Although findings are limited by lack of outcome data, they are in line with theories linking atypical eye processing to the emergence of ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3253-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study / B. Y. PARK in Molecular Autism, 8 (2017)
[article]
Titre : Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study Type de document : Texte imprimé et/ou numérique Auteurs : B. Y. PARK, Auteur ; Brian K. LEE, Auteur ; Igor BURSTYN, Auteur ; Loni P. TABB, Auteur ; J. A. KEELAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Lisa A. CROEN, Auteur ; M. D. FALLIN, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; O. MONTGOMERY, Auteur ; C. J. NEWSCHAFFER, Auteur Article en page(s) : 3p. Langues : Anglais (eng) Mots-clés : Adult Androstenedione/*metabolism Autism Spectrum Disorder/metabolism/*psychology Chromatography, Liquid Cohort Studies Dehydroepiandrosterone/*metabolism Female Fetal Blood/*metabolism Humans Infant Linear Models Longitudinal Studies Male Pregnancy Prospective Studies Risk Assessment Severity of Illness Index Siblings/*psychology Tandem Mass Spectrometry Testosterone/*metabolism *Autism *Sex difference *Sibling *Testosterone *Umbilical cord blood Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) affects more than 1% of children in the USA. The male-to-female prevalence ratio of roughly 4:1 in ASD is a well-recognized but poorly understood phenomenon. An explicit focus on potential etiologic pathways consistent with this sex difference, such as those involving prenatal androgen exposure, may help elucidate causes of ASD. Furthermore, the multi-threshold liability model suggests that the genetic mechanisms in females with ASD may be distinct and may modulate ASD risk in families with female ASD in the pedigree. METHODS: We examined umbilical cord blood from 137 children in the Early Autism Risk Longitudinal Investigation (EARLI) cohort. EARLI is an ASD-enriched risk cohort with all children having an older sibling already diagnosed with ASD. Fetal testosterone (T), androstenedione (A4), and dehyroepiandrosterone (DHEA) levels were measured in cord blood using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Robust linear regression models were used to determine associations between cord blood androgen levels and 12-month Autism Observation Scales for Infants (AOSI) scores and 36-month Social Responsiveness Scale (SRS) scores adjusting for potential confounders. RESULTS: Increasing androgens were not associated with increasing 12-month AOSI score or 36-month total SRS score in either boys or girls. However, the association between T and autistic traits among subjects with a female older affected sibling was greater at 12 months (test of interaction, P = 0.008) and deficits in reciprocal social behavior at 36 months were also greater (test of interaction, P = 0.006) than in subjects whose older affected sibling was male. CONCLUSIONS: While increased prenatal testosterone levels were not associated with autistic traits at 12 or 36 months, our findings of a positive association in infants whose older ASD-affected siblings were female suggests an androgen-related mechanism that may be dependent on, or related to, genetic liability factors present more often in families containing female ASD cases. However, this initial finding, based on a small subgroup of our sample, should be interpreted with considerable caution. En ligne : http://dx.doi.org/10.1186/s13229-017-0118-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 3p.[article] Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study [Texte imprimé et/ou numérique] / B. Y. PARK, Auteur ; Brian K. LEE, Auteur ; Igor BURSTYN, Auteur ; Loni P. TABB, Auteur ; J. A. KEELAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Lisa A. CROEN, Auteur ; M. D. FALLIN, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; O. MONTGOMERY, Auteur ; C. J. NEWSCHAFFER, Auteur . - 3p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 3p.
Mots-clés : Adult Androstenedione/*metabolism Autism Spectrum Disorder/metabolism/*psychology Chromatography, Liquid Cohort Studies Dehydroepiandrosterone/*metabolism Female Fetal Blood/*metabolism Humans Infant Linear Models Longitudinal Studies Male Pregnancy Prospective Studies Risk Assessment Severity of Illness Index Siblings/*psychology Tandem Mass Spectrometry Testosterone/*metabolism *Autism *Sex difference *Sibling *Testosterone *Umbilical cord blood Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) affects more than 1% of children in the USA. The male-to-female prevalence ratio of roughly 4:1 in ASD is a well-recognized but poorly understood phenomenon. An explicit focus on potential etiologic pathways consistent with this sex difference, such as those involving prenatal androgen exposure, may help elucidate causes of ASD. Furthermore, the multi-threshold liability model suggests that the genetic mechanisms in females with ASD may be distinct and may modulate ASD risk in families with female ASD in the pedigree. METHODS: We examined umbilical cord blood from 137 children in the Early Autism Risk Longitudinal Investigation (EARLI) cohort. EARLI is an ASD-enriched risk cohort with all children having an older sibling already diagnosed with ASD. Fetal testosterone (T), androstenedione (A4), and dehyroepiandrosterone (DHEA) levels were measured in cord blood using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Robust linear regression models were used to determine associations between cord blood androgen levels and 12-month Autism Observation Scales for Infants (AOSI) scores and 36-month Social Responsiveness Scale (SRS) scores adjusting for potential confounders. RESULTS: Increasing androgens were not associated with increasing 12-month AOSI score or 36-month total SRS score in either boys or girls. However, the association between T and autistic traits among subjects with a female older affected sibling was greater at 12 months (test of interaction, P = 0.008) and deficits in reciprocal social behavior at 36 months were also greater (test of interaction, P = 0.006) than in subjects whose older affected sibling was male. CONCLUSIONS: While increased prenatal testosterone levels were not associated with autistic traits at 12 or 36 months, our findings of a positive association in infants whose older ASD-affected siblings were female suggests an androgen-related mechanism that may be dependent on, or related to, genetic liability factors present more often in families containing female ASD cases. However, this initial finding, based on a small subgroup of our sample, should be interpreted with considerable caution. En ligne : http://dx.doi.org/10.1186/s13229-017-0118-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 Early Pandemic Experiences of Autistic Adults: Predictors of Psychological Distress / Vanessa H. BAL in Autism Research, 14-6 (June 2021)
[article]
Titre : Early Pandemic Experiences of Autistic Adults: Predictors of Psychological Distress Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa H. BAL, Auteur ; E. WILKINSON, Auteur ; L. C. WHITE, Auteur ; J. K. LAW, Auteur ; P. FELICIANO, Auteur ; W. K. CHUNG, Auteur Article en page(s) : p.1209-1219 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autistic Disorder/psychology COVID-19/epidemiology Female Health Surveys Hope Humans Internet Male Pandemics Psychological Distress Risk Assessment Stress, Psychological/psychology Young Adult COVID-19 pandemic adults co-morbid conditions gender/female ASD hope loneliness funding from Novartis, Roche, Pfizer, Biogen, Ipsen, LAM Therapeutics, Astellas, Bridgebio and Quadrant Biosciences and has served on the Scientific Advisory Boards for Sage Therapeutics, Roche, Celgene, Aeovian, Regenxbio and Takeda. Robin Kochel has a contract with Yamo Pharmaceuticals, Inc., to consult on the design of clinical trials for individuals with ASD. Suma Jacobs has been an investigator in multisite treatment trials by Roche and served on an autism advisory board for Roche. Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic has disrupted lives around the world. Autistic adults are at higher risk for co-occurring medical and psychiatric conditions and may be more prone to difficulties adapting to pandemic-related changes and social distancing mandates and coping with ongoing uncertainties. On the other hand, the pandemic may lead to greater understanding and acceptance of accommodations in the broader community that may facilitate supports for autistic adults beyond the pandemic. To learn more about their early pandemic experiences, online surveys were sent to independent adults enrolled in the Simons Powering Autism Research Knowledge (SPARK). The first survey was open from March 30 to April 19, 2020; a follow-up survey sent to original responders was open from May 27 to June 6, yielding 396 participants with data for both surveys. We found that adults who were female, younger, had prior diagnoses of a mental health condition, personal COVID-19 experience (i.e., knowing someone who had symptoms or tested positive) or less frequent hope for the future reported the greatest negative impacts. Decrease in feelings of hopefulness over time predicted greater psychological distress at T2, accounting for T1 impact and distress levels and increases in total COVID-19 impact. Less perceived benefit of online services also predicted later distress. Although there tends to be a focus on coping with negative effects of the pandemic, mental health providers may consider approaches that focus on positives, such as fostering hope and understanding factors that facilitate benefit from online services. LAY SUMMARY: Autistic adults may be at risk for psychological distress during the COVID-19 pandemic. The current study suggests that autistic adults who were younger, female, had a mental health diagnosis before the pandemic and knew someone who showed symptoms or tested positive for COVID-19 reported more areas negatively impacted by COVID-19 and greater difficulty coping with those effects. Decreases in hope over time were associated with greater psychological distress. Less perceived benefit from online services also predicted distress 2?months later. These results suggest important areas to further explore as we develop supports for autistic adults during the pandemic. En ligne : http://dx.doi.org/10.1002/aur.2480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-6 (June 2021) . - p.1209-1219[article] Early Pandemic Experiences of Autistic Adults: Predictors of Psychological Distress [Texte imprimé et/ou numérique] / Vanessa H. BAL, Auteur ; E. WILKINSON, Auteur ; L. C. WHITE, Auteur ; J. K. LAW, Auteur ; P. FELICIANO, Auteur ; W. K. CHUNG, Auteur . - p.1209-1219.
Langues : Anglais (eng)
in Autism Research > 14-6 (June 2021) . - p.1209-1219
Mots-clés : Adolescent Adult Autistic Disorder/psychology COVID-19/epidemiology Female Health Surveys Hope Humans Internet Male Pandemics Psychological Distress Risk Assessment Stress, Psychological/psychology Young Adult COVID-19 pandemic adults co-morbid conditions gender/female ASD hope loneliness funding from Novartis, Roche, Pfizer, Biogen, Ipsen, LAM Therapeutics, Astellas, Bridgebio and Quadrant Biosciences and has served on the Scientific Advisory Boards for Sage Therapeutics, Roche, Celgene, Aeovian, Regenxbio and Takeda. Robin Kochel has a contract with Yamo Pharmaceuticals, Inc., to consult on the design of clinical trials for individuals with ASD. Suma Jacobs has been an investigator in multisite treatment trials by Roche and served on an autism advisory board for Roche. Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic has disrupted lives around the world. Autistic adults are at higher risk for co-occurring medical and psychiatric conditions and may be more prone to difficulties adapting to pandemic-related changes and social distancing mandates and coping with ongoing uncertainties. On the other hand, the pandemic may lead to greater understanding and acceptance of accommodations in the broader community that may facilitate supports for autistic adults beyond the pandemic. To learn more about their early pandemic experiences, online surveys were sent to independent adults enrolled in the Simons Powering Autism Research Knowledge (SPARK). The first survey was open from March 30 to April 19, 2020; a follow-up survey sent to original responders was open from May 27 to June 6, yielding 396 participants with data for both surveys. We found that adults who were female, younger, had prior diagnoses of a mental health condition, personal COVID-19 experience (i.e., knowing someone who had symptoms or tested positive) or less frequent hope for the future reported the greatest negative impacts. Decrease in feelings of hopefulness over time predicted greater psychological distress at T2, accounting for T1 impact and distress levels and increases in total COVID-19 impact. Less perceived benefit of online services also predicted later distress. Although there tends to be a focus on coping with negative effects of the pandemic, mental health providers may consider approaches that focus on positives, such as fostering hope and understanding factors that facilitate benefit from online services. LAY SUMMARY: Autistic adults may be at risk for psychological distress during the COVID-19 pandemic. The current study suggests that autistic adults who were younger, female, had a mental health diagnosis before the pandemic and knew someone who showed symptoms or tested positive for COVID-19 reported more areas negatively impacted by COVID-19 and greater difficulty coping with those effects. Decreases in hope over time were associated with greater psychological distress. Less perceived benefit from online services also predicted distress 2?months later. These results suggest important areas to further explore as we develop supports for autistic adults during the pandemic. En ligne : http://dx.doi.org/10.1002/aur.2480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies / Michelle I. J. SNIJDER in Journal of Autism and Developmental Disorders, 52-8 (August 2022)
[article]
Titre : Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies Type de document : Texte imprimé et/ou numérique Auteurs : Michelle I. J. SNIJDER, Auteur ; Ilse P. C. LANGERAK, Auteur ; Shireen P. T. KAIJADOE, Auteur ; Marrit E. BURUMA, Auteur ; Rianne VERSCHUUR, Auteur ; Claudine DIETZ, Auteur ; Jan K. BUITELAAR, Auteur ; Iris J. OOSTERLING, Auteur Article en page(s) : p.3473-3485 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/therapy Autistic Disorder/diagnosis/therapy Child Early Diagnosis Humans Parents Risk Assessment Autism spectrum disorder Early detection Improvement strategies Parental experiences Preventive care board of/and/or speaker for Takeda/Shire, Roche, Medice, Angelini, Janssen, and Servier. He is not an employee of any of these companies, and not a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patents, royalties. Index. décimale : PER Périodiques Résumé : Whereas it is well documented how parents experience the diagnostic process of their child with autism spectrum disorder (ASD), less is known about parental experiences with the course of the early identification process and first steps in receiving care for their child with ASD symptoms. This mixed-method study investigated these experiences as well as barriers and improvement strategies regarding early detection in the Netherlands. A parental survey (N=45) showed that, on average, initial concerns started at 22Â months. A focus group (N=10) revealed multiple barriers and proposed strategies of improvement in three domains: "Knowledge and Expertise", "Attention to Parental Needs" and "System and Organization". Strategies to improve early identification will be discussed based on parental perspectives and professional perspectives. En ligne : http://dx.doi.org/10.1007/s10803-021-05226-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Journal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3473-3485[article] Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies [Texte imprimé et/ou numérique] / Michelle I. J. SNIJDER, Auteur ; Ilse P. C. LANGERAK, Auteur ; Shireen P. T. KAIJADOE, Auteur ; Marrit E. BURUMA, Auteur ; Rianne VERSCHUUR, Auteur ; Claudine DIETZ, Auteur ; Jan K. BUITELAAR, Auteur ; Iris J. OOSTERLING, Auteur . - p.3473-3485.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3473-3485
Mots-clés : Autism Spectrum Disorder/diagnosis/therapy Autistic Disorder/diagnosis/therapy Child Early Diagnosis Humans Parents Risk Assessment Autism spectrum disorder Early detection Improvement strategies Parental experiences Preventive care board of/and/or speaker for Takeda/Shire, Roche, Medice, Angelini, Janssen, and Servier. He is not an employee of any of these companies, and not a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patents, royalties. Index. décimale : PER Périodiques Résumé : Whereas it is well documented how parents experience the diagnostic process of their child with autism spectrum disorder (ASD), less is known about parental experiences with the course of the early identification process and first steps in receiving care for their child with ASD symptoms. This mixed-method study investigated these experiences as well as barriers and improvement strategies regarding early detection in the Netherlands. A parental survey (N=45) showed that, on average, initial concerns started at 22Â months. A focus group (N=10) revealed multiple barriers and proposed strategies of improvement in three domains: "Knowledge and Expertise", "Attention to Parental Needs" and "System and Organization". Strategies to improve early identification will be discussed based on parental perspectives and professional perspectives. En ligne : http://dx.doi.org/10.1007/s10803-021-05226-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485