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Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review / N. M. TALGE in Autism Research, 11-6 (June 2018)
[article]
Titre : Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review Type de document : Texte imprimé et/ou numérique Auteurs : N. M. TALGE, Auteur ; B. M. TUDOR, Auteur ; P. R. KILENY, Auteur Article en page(s) : p.916-927 Langues : Anglais (eng) Mots-clés : auditory autism spectrum disorder brain stem evoked potentials Index. décimale : PER Périodiques Résumé : Behavior does not differentiate ASD risk prior to 12 months of age, but biomarkers may inform risk before symptoms emerge. Click-evoked auditory brainstem responses (ABRs) may be worth consideration due to their measurement properties (noninvasiveness; reliability) and conceptual features (well-characterized neural generators), but participant characteristics and assessment protocols vary considerably across studies. Our goal is to perform a meta-analysis of the association between ABRs and ASD. Following an electronic database search (PubMed, Medline, PsycInfo, PsycArticles), we included papers that were written in English, included ASD and typically-developing (TD) groups, and reported the information needed to calculate standardized mean differences (Hedges's g) for at least one ABR latency component (I, III, V, I-III, III-V, I-V). We weighted and averaged effect sizes across conditions and subsets of participants to yield one estimate per component per study. We then performed random-effects regressions to generate component-specific estimates. ASD was associated with longer ABR latencies for Waves III (g = 0.5, 95% CI 0.1, 0.9), V (g = 0.7, 95% CI 0.3, 1.1), I-III (g = 0.7, 95% CI 0.2, 1.2), and I-V (g = 0.6, 95% CI 0.2, 1.0). All components showed significant heterogeneity. Associations were strongest among participants =8 years of age and those without middle ear abnormalities or elevated auditory thresholds. In sum, associations between ABRs and ASD are medium-to-large in size, but exhibit heterogeneity. Identifying sources of heterogeneity is challenging, however, due to power limitations and co-occurrence of sample/design characteristics across studies. Research addressing the above limitations is crucial to determining the etiologic and/or prognostic value of ABRs for ASD. Autism Res 2018, 11: 916-927. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Auditory brainstem responses (ABR) may be associated with ASD, but participant characteristics and assessment protocols vary considerably across individual studies. Our goal is to combine the results across these studies to facilitate clarity on the topic. Doing so represents a first step in evaluating whether ABRs yield potential for informing the etiology of ASD risk and/or ASD symptom profiles. En ligne : http://dx.doi.org/10.1002/aur.1946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Autism Research > 11-6 (June 2018) . - p.916-927[article] Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review [Texte imprimé et/ou numérique] / N. M. TALGE, Auteur ; B. M. TUDOR, Auteur ; P. R. KILENY, Auteur . - p.916-927.
Langues : Anglais (eng)
in Autism Research > 11-6 (June 2018) . - p.916-927
Mots-clés : auditory autism spectrum disorder brain stem evoked potentials Index. décimale : PER Périodiques Résumé : Behavior does not differentiate ASD risk prior to 12 months of age, but biomarkers may inform risk before symptoms emerge. Click-evoked auditory brainstem responses (ABRs) may be worth consideration due to their measurement properties (noninvasiveness; reliability) and conceptual features (well-characterized neural generators), but participant characteristics and assessment protocols vary considerably across studies. Our goal is to perform a meta-analysis of the association between ABRs and ASD. Following an electronic database search (PubMed, Medline, PsycInfo, PsycArticles), we included papers that were written in English, included ASD and typically-developing (TD) groups, and reported the information needed to calculate standardized mean differences (Hedges's g) for at least one ABR latency component (I, III, V, I-III, III-V, I-V). We weighted and averaged effect sizes across conditions and subsets of participants to yield one estimate per component per study. We then performed random-effects regressions to generate component-specific estimates. ASD was associated with longer ABR latencies for Waves III (g = 0.5, 95% CI 0.1, 0.9), V (g = 0.7, 95% CI 0.3, 1.1), I-III (g = 0.7, 95% CI 0.2, 1.2), and I-V (g = 0.6, 95% CI 0.2, 1.0). All components showed significant heterogeneity. Associations were strongest among participants =8 years of age and those without middle ear abnormalities or elevated auditory thresholds. In sum, associations between ABRs and ASD are medium-to-large in size, but exhibit heterogeneity. Identifying sources of heterogeneity is challenging, however, due to power limitations and co-occurrence of sample/design characteristics across studies. Research addressing the above limitations is crucial to determining the etiologic and/or prognostic value of ABRs for ASD. Autism Res 2018, 11: 916-927. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Auditory brainstem responses (ABR) may be associated with ASD, but participant characteristics and assessment protocols vary considerably across individual studies. Our goal is to combine the results across these studies to facilitate clarity on the topic. Doing so represents a first step in evaluating whether ABRs yield potential for informing the etiology of ASD risk and/or ASD symptom profiles. En ligne : http://dx.doi.org/10.1002/aur.1946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder / Kaela E. SCOTT in Autism Research, 14-7 (July 2021)
[article]
Titre : Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kaela E. SCOTT, Auteur ; S. E. SCHULZ, Auteur ; D. MOEHRLE, Auteur ; Brian L. ALLMAN, Auteur ; Janis ORAM CARDY, Auteur ; R. A. STEVENSON, Auteur ; S. SCHMID, Auteur Article en page(s) : p.1322-1331 Langues : Anglais (eng) Mots-clés : Animals Autism Spectrum Disorder Cognition Evoked Potentials Humans Mice Perception Sensation auditory processing experimental design framework sensory phenotypes species translation Index. décimale : PER Périodiques Résumé : The study of sensory phenotypes has great potential for increasing research translation between species, a necessity to decipher the neural mechanisms that contribute to higher-order differences in neurological conditions such as autism spectrum disorder (ASD). Over the past decade, despite separate advances in our understanding of the structural and functional differences within the brain of autistic and non-autistic individuals and in rodent models for ASD, researchers have had difficulty translating the findings in murine species to humans, mostly due to incompatibility in experimental methodologies used to screen for ASD phenotypes. Focusing on sensory phenotypes offers an avenue to close the species gap because sensory pathways are highly conserved across species and are affected by the same risk-factors as the higher-order brain areas mostly responsible for the diagnostic criteria for ASD. By first reviewing how sensory processing has been studied to date, we direct our focus to electrophysiological and behavioral techniques that can be used to study sensory phenotypes consistently across species. Using auditory sensory phenotypes as a template, we seek to improve the accessibility of translational methods by providing a framework for collecting cohesive data in both rodents and humans. Specifically, evoked-potentials, acoustic startle paradigms, and psychophysical detection/discrimination paradigms can be created and implemented in a coordinated and systematic fashion across species. Through careful protocol design and collaboration, sensory processing phenotypes can be harnessed to bridge the gap that exists between preclinical animal studies and human testing, so that mutually held questions in autism research can be answered. LAY SUMMARY: It has always been difficult to relate results from animal research to humans. We try to close this gap by studying changes in sensory processing using careful protocol design and collaboration between clinicians and researchers. Sensory pathways are comparable between animals and humans, and are affected in the same way as the rest of the brain in ASD. Using changes in hearing as a template, we point the field in an innovative direction by providing a framework for collecting cohesive data in rodents and humans. En ligne : http://dx.doi.org/10.1002/aur.2533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-7 (July 2021) . - p.1322-1331[article] Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder [Texte imprimé et/ou numérique] / Kaela E. SCOTT, Auteur ; S. E. SCHULZ, Auteur ; D. MOEHRLE, Auteur ; Brian L. ALLMAN, Auteur ; Janis ORAM CARDY, Auteur ; R. A. STEVENSON, Auteur ; S. SCHMID, Auteur . - p.1322-1331.
Langues : Anglais (eng)
in Autism Research > 14-7 (July 2021) . - p.1322-1331
Mots-clés : Animals Autism Spectrum Disorder Cognition Evoked Potentials Humans Mice Perception Sensation auditory processing experimental design framework sensory phenotypes species translation Index. décimale : PER Périodiques Résumé : The study of sensory phenotypes has great potential for increasing research translation between species, a necessity to decipher the neural mechanisms that contribute to higher-order differences in neurological conditions such as autism spectrum disorder (ASD). Over the past decade, despite separate advances in our understanding of the structural and functional differences within the brain of autistic and non-autistic individuals and in rodent models for ASD, researchers have had difficulty translating the findings in murine species to humans, mostly due to incompatibility in experimental methodologies used to screen for ASD phenotypes. Focusing on sensory phenotypes offers an avenue to close the species gap because sensory pathways are highly conserved across species and are affected by the same risk-factors as the higher-order brain areas mostly responsible for the diagnostic criteria for ASD. By first reviewing how sensory processing has been studied to date, we direct our focus to electrophysiological and behavioral techniques that can be used to study sensory phenotypes consistently across species. Using auditory sensory phenotypes as a template, we seek to improve the accessibility of translational methods by providing a framework for collecting cohesive data in both rodents and humans. Specifically, evoked-potentials, acoustic startle paradigms, and psychophysical detection/discrimination paradigms can be created and implemented in a coordinated and systematic fashion across species. Through careful protocol design and collaboration, sensory processing phenotypes can be harnessed to bridge the gap that exists between preclinical animal studies and human testing, so that mutually held questions in autism research can be answered. LAY SUMMARY: It has always been difficult to relate results from animal research to humans. We try to close this gap by studying changes in sensory processing using careful protocol design and collaboration between clinicians and researchers. Sensory pathways are comparable between animals and humans, and are affected in the same way as the rest of the brain in ASD. Using changes in hearing as a template, we point the field in an innovative direction by providing a framework for collecting cohesive data in rodents and humans. En ligne : http://dx.doi.org/10.1002/aur.2533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Audiovisual Speech Perception in Children with Autism Spectrum Disorders: Evidence from Visual Phonemic Restoration / J. IRWIN in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
[article]
Titre : Audiovisual Speech Perception in Children with Autism Spectrum Disorders: Evidence from Visual Phonemic Restoration Type de document : Texte imprimé et/ou numérique Auteurs : J. IRWIN, Auteur ; T. AVERY, Auteur ; D. KLEINMAN, Auteur ; N. LANDI, Auteur Article en page(s) : p.28-37 Langues : Anglais (eng) Mots-clés : Auditory Perception Autism Spectrum Disorder Child Cues Evoked Potentials Humans Speech Speech Perception Visual Perception Audiovisual Autism Phonemic restoration Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders have been reported to be less influenced by a speaker's face during speech perception than those with typically development. To more closely examine these reported differences, a novel visual phonemic restoration paradigm was used to assess neural signatures (event-related potentials [ERPs]) of audiovisual processing in typically developing children and in children with autism spectrum disorder. Video of a speaker saying the syllable /ba/ was paired with (1) a synthesized /ba/ or (2) a synthesized syllable derived from /ba/ in which auditory cues for the consonant were substantially weakened, thereby sounding more like /a/. The auditory stimuli are easily discriminable; however, in the context of a visual /ba/, the auditory /a/ is typically perceived as /ba/, producing a visual phonemic restoration. Only children with ASD showed a large /ba/-/a/ discrimination response in the presence of a speaker producing /ba/, suggesting reduced influence of visual speech. En ligne : http://dx.doi.org/10.1007/s10803-021-04916-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.28-37[article] Audiovisual Speech Perception in Children with Autism Spectrum Disorders: Evidence from Visual Phonemic Restoration [Texte imprimé et/ou numérique] / J. IRWIN, Auteur ; T. AVERY, Auteur ; D. KLEINMAN, Auteur ; N. LANDI, Auteur . - p.28-37.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.28-37
Mots-clés : Auditory Perception Autism Spectrum Disorder Child Cues Evoked Potentials Humans Speech Speech Perception Visual Perception Audiovisual Autism Phonemic restoration Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders have been reported to be less influenced by a speaker's face during speech perception than those with typically development. To more closely examine these reported differences, a novel visual phonemic restoration paradigm was used to assess neural signatures (event-related potentials [ERPs]) of audiovisual processing in typically developing children and in children with autism spectrum disorder. Video of a speaker saying the syllable /ba/ was paired with (1) a synthesized /ba/ or (2) a synthesized syllable derived from /ba/ in which auditory cues for the consonant were substantially weakened, thereby sounding more like /a/. The auditory stimuli are easily discriminable; however, in the context of a visual /ba/, the auditory /a/ is typically perceived as /ba/, producing a visual phonemic restoration. Only children with ASD showed a large /ba/-/a/ discrimination response in the presence of a speaker producing /ba/, suggesting reduced influence of visual speech. En ligne : http://dx.doi.org/10.1007/s10803-021-04916-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study / O. V. SYSOEVA in Molecular Autism, 9 (2018)
[article]
Titre : Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study Type de document : Texte imprimé et/ou numérique Auteurs : O. V. SYSOEVA, Auteur ; John N. CONSTANTINO, Auteur ; Andrey P. ANOKHIN, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/physiopathology Child Electroencephalography Evoked Potentials Face Fathers Humans Male Middle Aged Pattern Recognition, Visual Siblings Young Adult Autistic disorder erp Electrophysiology Endophenotype N170 Index. décimale : PER Périodiques Résumé : Background: Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potentials (ERP) elicited by faces. Methods: We examined familial aggregation of face processing ERP abnormalities previously implicated in ASD in 49 verbal individuals with ASD, 36 unaffected siblings (US), 18 unaffected fathers (UF), and 53 unrelated controls (UC). The ASD, US, and UC groups ranged in age from 12 to 21 years, the UF group ranged in age from 30 to 56 years. ERP responses to images of upright and inverted faces and houses were analyzed under disparate EEG reference schemes. Results: Face-sensitive features of N170 and P1 were readily observed in all groups. Differences between ASD and control groups depended upon the EEG reference scheme. Notably, the superiority of face over object for N170 latency was attenuated in ASD subjects, but not their relatives; this occurred exclusively with the average reference. The difference in N170 amplitude between inverted and upright faces was reduced in both ASD and US groups relative to UC, but this effect was significant only with the vertex reference. Furthermore, similar group differences were observed for both inverted faces and inverted houses, suggesting a lack of face specificity for the attenuation of the N170 inversion effect in ASD. Conclusion: The present findings refine understanding of face processing ERPs in ASD. These data provide only modest evidence for highly-selective ASD-sensitive ERP features, and underscore the sensitivity of these biomarkers to ERP reference scheme. These schemes have varied across published studies and must be accounted for in future studies of the relationship between these commonly acquired ERP characteristics, genotype, and ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0220-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Molecular Autism > 9 (2018) . - 41p.[article] Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study [Texte imprimé et/ou numérique] / O. V. SYSOEVA, Auteur ; John N. CONSTANTINO, Auteur ; Andrey P. ANOKHIN, Auteur . - 41p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 41p.
Mots-clés : Adolescent Adult Autism Spectrum Disorder/physiopathology Child Electroencephalography Evoked Potentials Face Fathers Humans Male Middle Aged Pattern Recognition, Visual Siblings Young Adult Autistic disorder erp Electrophysiology Endophenotype N170 Index. décimale : PER Périodiques Résumé : Background: Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potentials (ERP) elicited by faces. Methods: We examined familial aggregation of face processing ERP abnormalities previously implicated in ASD in 49 verbal individuals with ASD, 36 unaffected siblings (US), 18 unaffected fathers (UF), and 53 unrelated controls (UC). The ASD, US, and UC groups ranged in age from 12 to 21 years, the UF group ranged in age from 30 to 56 years. ERP responses to images of upright and inverted faces and houses were analyzed under disparate EEG reference schemes. Results: Face-sensitive features of N170 and P1 were readily observed in all groups. Differences between ASD and control groups depended upon the EEG reference scheme. Notably, the superiority of face over object for N170 latency was attenuated in ASD subjects, but not their relatives; this occurred exclusively with the average reference. The difference in N170 amplitude between inverted and upright faces was reduced in both ASD and US groups relative to UC, but this effect was significant only with the vertex reference. Furthermore, similar group differences were observed for both inverted faces and inverted houses, suggesting a lack of face specificity for the attenuation of the N170 inversion effect in ASD. Conclusion: The present findings refine understanding of face processing ERPs in ASD. These data provide only modest evidence for highly-selective ASD-sensitive ERP features, and underscore the sensitivity of these biomarkers to ERP reference scheme. These schemes have varied across published studies and must be accounted for in future studies of the relationship between these commonly acquired ERP characteristics, genotype, and ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0220-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Effect of presentation rate on auditory processing in Rett syndrome: event-related potential study / Anna REBREIKINA ; Victoria VOINOVA ; Olga SYSOEVA in Molecular Autism, 14 (2023)
[article]
Titre : Effect of presentation rate on auditory processing in Rett syndrome: event-related potential study Type de document : Texte imprimé et/ou numérique Auteurs : Anna REBREIKINA, Auteur ; Victoria VOINOVA, Auteur ; Olga SYSOEVA, Auteur Article en page(s) : 40 p. Langues : Anglais (eng) Mots-clés : Child Humans Child, Preschool Adolescent *Rett Syndrome/diagnosis/genetics Evoked Potentials, Auditory/physiology Acoustic Stimulation Evoked Potentials Electroencephalography Auditory Perception/physiology Auditory event-related potential (ERP) Presentation rate Rett syndrome Stimulus-specific adaptation Index. décimale : PER Périodiques Résumé : BACKGROUND: Rett syndrome (RS) is a rare neurodevelopmental disorder characterized by mutations in the MECP2 gene. Patients with RS have severe motor abnormalities and are often unable to walk, use hands and speak. The preservation of perceptual and cognitive functions is hard to assess, while clinicians and care-givers point out that these patients need more time to process information than typically developing peers. Neurophysiological correlates of auditory processing have been also found to be distorted in RS, but sound presentation rates were relatively quick in these studies (stimulus onset asynchrony, SOA<1000 ms). As auditory event-related potential (ERP) is typically increased with prolongation of SOA we aim to study if SOA prolongation might compensate for observed abnormalities. METHODS: We presented a repetitive stimulus (1000 Hz) at three different SOAs of 900 ms, 1800 ms, and 3600 ms in children with RS (N=24, Mean age=9.0?+?3.1) and their typical development (TD) peers (N=27, Mean age=9.7?+?3.4) while recording 28-channels electroencephalogram, EEG. Some RS participants (n=10) did not show clear ERP and were excluded from the analysis. RESULTS: Major ERP components (here assessed as N1P1 and P2N1 peak-to-peak values) were smaller at SOA 900 than at longer SOAs in both groups, pointing out that the basic mechanism of adaptation in the auditory system is preserved in at least in RS patients with evident ERPs. At the same time the latencies of these components were significantly delayed in the RS than in TD. Moreover, late components (P2N1 and N2P2) were drastically reduced in Rett syndrome irrespective of the SOA, suggesting a largely affected mechanism of integration of upcoming sensory input with memory. Moreover, developmental stagnation of auditory ERP characterized patients with RS: absence of typical P2N1 enlargement and P1 and N1 shortening with age at least for shortest SOA. LIMITATIONS: We could not figure out the cause for the high percentage of no-evident ERP RS participants and our final sample of the RS group was rather small. Also, our study did not include a control clinical group. CONCLUSIONS: Thus, auditory ERPs inform us about abnormalities within auditory processing that cannot be fully overcomed by slowing presentation rate. En ligne : https://dx.doi.org/10.1186/s13229-023-00566-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518
in Molecular Autism > 14 (2023) . - 40 p.[article] Effect of presentation rate on auditory processing in Rett syndrome: event-related potential study [Texte imprimé et/ou numérique] / Anna REBREIKINA, Auteur ; Victoria VOINOVA, Auteur ; Olga SYSOEVA, Auteur . - 40 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 40 p.
Mots-clés : Child Humans Child, Preschool Adolescent *Rett Syndrome/diagnosis/genetics Evoked Potentials, Auditory/physiology Acoustic Stimulation Evoked Potentials Electroencephalography Auditory Perception/physiology Auditory event-related potential (ERP) Presentation rate Rett syndrome Stimulus-specific adaptation Index. décimale : PER Périodiques Résumé : BACKGROUND: Rett syndrome (RS) is a rare neurodevelopmental disorder characterized by mutations in the MECP2 gene. Patients with RS have severe motor abnormalities and are often unable to walk, use hands and speak. The preservation of perceptual and cognitive functions is hard to assess, while clinicians and care-givers point out that these patients need more time to process information than typically developing peers. Neurophysiological correlates of auditory processing have been also found to be distorted in RS, but sound presentation rates were relatively quick in these studies (stimulus onset asynchrony, SOA<1000 ms). As auditory event-related potential (ERP) is typically increased with prolongation of SOA we aim to study if SOA prolongation might compensate for observed abnormalities. METHODS: We presented a repetitive stimulus (1000 Hz) at three different SOAs of 900 ms, 1800 ms, and 3600 ms in children with RS (N=24, Mean age=9.0?+?3.1) and their typical development (TD) peers (N=27, Mean age=9.7?+?3.4) while recording 28-channels electroencephalogram, EEG. Some RS participants (n=10) did not show clear ERP and were excluded from the analysis. RESULTS: Major ERP components (here assessed as N1P1 and P2N1 peak-to-peak values) were smaller at SOA 900 than at longer SOAs in both groups, pointing out that the basic mechanism of adaptation in the auditory system is preserved in at least in RS patients with evident ERPs. At the same time the latencies of these components were significantly delayed in the RS than in TD. Moreover, late components (P2N1 and N2P2) were drastically reduced in Rett syndrome irrespective of the SOA, suggesting a largely affected mechanism of integration of upcoming sensory input with memory. Moreover, developmental stagnation of auditory ERP characterized patients with RS: absence of typical P2N1 enlargement and P1 and N1 shortening with age at least for shortest SOA. LIMITATIONS: We could not figure out the cause for the high percentage of no-evident ERP RS participants and our final sample of the RS group was rather small. Also, our study did not include a control clinical group. CONCLUSIONS: Thus, auditory ERPs inform us about abnormalities within auditory processing that cannot be fully overcomed by slowing presentation rate. En ligne : https://dx.doi.org/10.1186/s13229-023-00566-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 Autistic Adults are Not Impaired at Maintaining or Switching Between Counterfactual and Factual Worlds: An ERP Study / H. J. FERGUSON in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
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