Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex / J. Christopher EDGAR in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-14 Titre : Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex Type de document : Texte imprimé et/ou numérique Auteurs : J. Christopher EDGAR, Auteur ; Charles L. FISK IV, Auteur ; Jeffrey I. BERMAN, Auteur ; Darina CHUDNOVSKAYA, Auteur ; Song LIU, Auteur ; Juhi PANDEY, Auteur ; John D. HERRINGTON, Auteur ; Russell G. PORT, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus auditory responses, pre- and post-stimulus superior temporal gyrus (STG) auditory oscillatory abnormalities, and atypical hemispheric lateralization. These abnormalities are likely associated with abnormal brain maturation. To better understand changes in brain activity as a function of age, the present study investigated associations between age and STG auditory time-domain and time-frequency neural activity. En ligne : http://dx.doi.org/10.1186/s13229-015-0065-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex [Texte imprimé et/ou numérique] / J. Christopher EDGAR, Auteur ; Charles L. FISK IV, Auteur ; Jeffrey I. BERMAN, Auteur ; Darina CHUDNOVSKAYA, Auteur ; Song LIU, Auteur ; Juhi PANDEY, Auteur ; John D. HERRINGTON, Auteur ; Russell G. PORT, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus auditory responses, pre- and post-stimulus superior temporal gyrus (STG) auditory oscillatory abnormalities, and atypical hemispheric lateralization. These abnormalities are likely associated with abnormal brain maturation. To better understand changes in brain activity as a function of age, the present study investigated associations between age and STG auditory time-domain and time-frequency neural activity. En ligne : http://dx.doi.org/10.1186/s13229-015-0065-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development / Heather L. GREEN in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089 Titre : Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development Type de document : Texte imprimé et/ou numérique Auteurs : Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P. L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur Article en page(s) : p.4076-4089 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~?18 months later at Time 2 (T2), and?~?36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development [Texte imprimé et/ou numérique] / Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P. L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur . - p.4076-4089. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089 Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~?18 months later at Time 2 (T2), and?~?36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

DTI and Tractography in the Autistic Brain / Timothy P.L. ROBERTS

Public ISBD in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM Titre : DTI and Tractography in the Autistic Brain Type de document : Texte imprimé et/ou numérique Auteurs : Timothy P.L. ROBERTS, Auteur ; Jeffrey I. BERMAN, Auteur ; Ragini VERMA, Auteur Année de publication : 2013 Importance : p.267-279 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Diffusion tensor imaging (DTI) and associated fiber tractography are an emerging MRI technique for studying white matter of the brain. This chapter presents an introduction to the physical and biological bases of diffusion in white matter and the development and analysis of diffusion tensor imaging. It also includes visualization of white matter fiber tracts and quantification of physical diffusion parameters, such as the mean diffusivity (MD) and fractional anisotropy (FA) that might be used to index white matter maturation. A review of the recent findings made using DTI in ASD (autism spectrum disorder) is presented, focusing on studies with large (gt;20) sample sizes. Common themes of elevated mean diffusivity and diminished fractional anisotropy emerge, especially in structures of the frontal and temporal lobes, but also in the corpus callosum. Voxel-based as well as regional connectivity approaches to extracting quantitative information from DTI are discussed along with approaches involving machine learning of pattern classifiers to distinguish ASD from TD and also identify key features (structures, regions or connections) that contribute most to that discrimination ability. Limitations of tractography based on DTI are discussed along with the emerging advance of high angular resolution diffusion imaging (HARDI) as a means to overcome DTI limitations in regions of complex white matter organization. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM DTI and Tractography in the Autistic Brain [Texte imprimé et/ou numérique] / Timothy P.L. ROBERTS, Auteur ; Jeffrey I. BERMAN, Auteur ; Ragini VERMA, Auteur . - 2013 . - p.267-279. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Diffusion tensor imaging (DTI) and associated fiber tractography are an emerging MRI technique for studying white matter of the brain. This chapter presents an introduction to the physical and biological bases of diffusion in white matter and the development and analysis of diffusion tensor imaging. It also includes visualization of white matter fiber tracts and quantification of physical diffusion parameters, such as the mean diffusivity (MD) and fractional anisotropy (FA) that might be used to index white matter maturation. A review of the recent findings made using DTI in ASD (autism spectrum disorder) is presented, focusing on studies with large (gt;20) sample sizes. Common themes of elevated mean diffusivity and diminished fractional anisotropy emerge, especially in structures of the frontal and temporal lobes, but also in the corpus callosum. Voxel-based as well as regional connectivity approaches to extracting quantitative information from DTI are discussed along with approaches involving machine learning of pattern classifiers to distinguish ASD from TD and also identify key features (structures, regions or connections) that contribute most to that discrimination ability. Limitations of tractography based on DTI are discussed along with the emerging advance of high angular resolution diffusion imaging (HARDI) as a means to overcome DTI limitations in regions of complex white matter organization. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189

Exemplaires

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A Multimodal Study of the Contributions of Conduction Velocity to the Auditory Evoked Neuromagnetic Response: Anomalies in Autism Spectrum Disorder / Timothy P. L. ROBERTS in Autism Research, 13-10 (October 2020)  

Public ISBD [article]  inAutism Research > 13-10 (October 2020) . - p.1730-1745 Titre : A Multimodal Study of the Contributions of Conduction Velocity to the Auditory Evoked Neuromagnetic Response: Anomalies in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Timothy P. L. ROBERTS, Auteur ; Luke BLOY, Auteur ; Matt KU, Auteur ; Lisa BLASKEY, Auteur ; Carissa R. JACKEL, Auteur ; James Christopher EDGAR, Auteur ; Jeffrey I. BERMAN, Auteur Article en page(s) : p.1730-1745 Langues : Anglais (eng) Mots-clés : MR spectroscopy  autism spectrum disorder  conduction velocity  diffusion MRI  magnetoencephalography  multimodal imaging Index. décimale : PER Périodiques Résumé : This multimodal imaging study used magnetoencephalography, diffusion magnetic resonance imaging (MRI), and gamma-aminobutyric acid (GABA) magnetic resonance spectroscopy (MRS) to identify and contrast the multiple physiological mechanisms associated with auditory processing efficiency in typically developing (TD) children and children with autism spectrum disorder (ASD). Efficient transmission of auditory input between the ear and auditory cortex is necessary for rapid encoding of auditory sensory information. It was hypothesized that the M50 auditory evoked response latency would be modulated by white matter microstructure (indexed by diffusion MRI) and by tonic inhibition (indexed by GABA MRS). Participants were 77 children diagnosed with ASD and 40 TD controls aged 7-17?years. A model of M50 latency with auditory radiation fractional anisotropy and age as independent variables was able to predict 52% of M50 latency variance in TD children, but only 12% of variance in ASD. The ASD group exhibited altered patterns of M50 latency modulation characterized by both higher variance and deviation from the expected structure-function relationship established with the TD group. The TD M50 latency model was used to identify a subpopulation of ASD who are significant "outliers" to the TD model. The ASD outlier group exhibited unexpectedly long M50 latencies in conjunction with significantly lower GABA levels. These findings indicate the dependence of electrophysiologic sensory response latency on underlying microstructure (white matter) and neurochemistry (synaptic activity). This study demonstrates the use of biologically based measures to stratify ASD according to their brain-level "building blocks" as an alternative to their behavioral phenotype. LAY SUMMARY: Children with ASD often have a slower brain response when hearing sounds. This study used multiple brain imaging techniques to examine the structural and neurochemical factors which control the brain's response time to auditory tones in children with ASD and TD children. The relationship between brain imaging measures and brain response time was also used to identify ASD subgroups. Autism Res 2020, 13: 1730-1745. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] A Multimodal Study of the Contributions of Conduction Velocity to the Auditory Evoked Neuromagnetic Response: Anomalies in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Timothy P. L. ROBERTS, Auteur ; Luke BLOY, Auteur ; Matt KU, Auteur ; Lisa BLASKEY, Auteur ; Carissa R. JACKEL, Auteur ; James Christopher EDGAR, Auteur ; Jeffrey I. BERMAN, Auteur . - p.1730-1745. Langues : Anglais (eng) in Autism Research > 13-10 (October 2020) . - p.1730-1745 Mots-clés : MR spectroscopy  autism spectrum disorder  conduction velocity  diffusion MRI  magnetoencephalography  multimodal imaging Index. décimale : PER Périodiques Résumé : This multimodal imaging study used magnetoencephalography, diffusion magnetic resonance imaging (MRI), and gamma-aminobutyric acid (GABA) magnetic resonance spectroscopy (MRS) to identify and contrast the multiple physiological mechanisms associated with auditory processing efficiency in typically developing (TD) children and children with autism spectrum disorder (ASD). Efficient transmission of auditory input between the ear and auditory cortex is necessary for rapid encoding of auditory sensory information. It was hypothesized that the M50 auditory evoked response latency would be modulated by white matter microstructure (indexed by diffusion MRI) and by tonic inhibition (indexed by GABA MRS). Participants were 77 children diagnosed with ASD and 40 TD controls aged 7-17?years. A model of M50 latency with auditory radiation fractional anisotropy and age as independent variables was able to predict 52% of M50 latency variance in TD children, but only 12% of variance in ASD. The ASD group exhibited altered patterns of M50 latency modulation characterized by both higher variance and deviation from the expected structure-function relationship established with the TD group. The TD M50 latency model was used to identify a subpopulation of ASD who are significant "outliers" to the TD model. The ASD outlier group exhibited unexpectedly long M50 latencies in conjunction with significantly lower GABA levels. These findings indicate the dependence of electrophysiologic sensory response latency on underlying microstructure (white matter) and neurochemistry (synaptic activity). This study demonstrates the use of biologically based measures to stratify ASD according to their brain-level "building blocks" as an alternative to their behavioral phenotype. LAY SUMMARY: Children with ASD often have a slower brain response when hearing sounds. This study used multiple brain imaging techniques to examine the structural and neurochemical factors which control the brain's response time to auditory tones in children with ASD and TD children. The relationship between brain imaging measures and brain response time was also used to identify ASD subgroups. Autism Res 2020, 13: 1730-1745. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Peak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder / H. L. GREEN in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.103-112 Titre : Peak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : H. L. GREEN, Auteur ; M. DIPIERO, Auteur ; S. KOPPERS, Auteur ; Jeffrey I. BERMAN, Auteur ; Luke BLOY, Auteur ; S. LIU, Auteur ; E. MCBRIDE, Auteur ; M. KU, Auteur ; Lisa BLASKEY, Auteur ; E. KUSCHNER, Auteur ; M. AIREY, Auteur ; M. KIM, Auteur ; K. KONKA, Auteur ; T. P. L. ROBERTS, Auteur ; J. C. EDGAR, Auteur Article en page(s) : p.103-112 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Alpha  Autism spectrum disorder  Magnetoencephalography  Maturation  Resting-state  Thalamic volume Index. décimale : PER Périodiques Résumé : Associations between age, resting-state (RS) peak-alpha-frequency (PAF?=?frequency showing largest amplitude alpha activity), and thalamic volume (thalamus thought to modulate alpha activity) were examined to understand differences in RS alpha activity between children with autism spectrum disorder (ASD) and typically-developing children (TDC) noted in prior studies. RS MEG and structural-MRI data were obtained from 51 ASD and 70 TDC 6- to 18-year-old males. PAF and thalamic volume maturation were observed in TDC but not ASD. Although PAF was associated with right thalamic volume in TDC (R(2)?=?0.12, p?=?0.01) but not ASD (R(2)?=?0.01, p?=?0.35), this group difference was not large enough to reach significance. Findings thus showed unusual maturation of brain function and structure in ASD as well as an across-group thalamic contribution to alpha rhythms. En ligne : http://dx.doi.org/10.1007/s10803-021-04926-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Peak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder [Texte imprimé et/ou numérique] / H. L. GREEN, Auteur ; M. DIPIERO, Auteur ; S. KOPPERS, Auteur ; Jeffrey I. BERMAN, Auteur ; Luke BLOY, Auteur ; S. LIU, Auteur ; E. MCBRIDE, Auteur ; M. KU, Auteur ; Lisa BLASKEY, Auteur ; E. KUSCHNER, Auteur ; M. AIREY, Auteur ; M. KIM, Auteur ; K. KONKA, Auteur ; T. P. L. ROBERTS, Auteur ; J. C. EDGAR, Auteur . - p.103-112. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.103-112 Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Alpha  Autism spectrum disorder  Magnetoencephalography  Maturation  Resting-state  Thalamic volume Index. décimale : PER Périodiques Résumé : Associations between age, resting-state (RS) peak-alpha-frequency (PAF?=?frequency showing largest amplitude alpha activity), and thalamic volume (thalamus thought to modulate alpha activity) were examined to understand differences in RS alpha activity between children with autism spectrum disorder (ASD) and typically-developing children (TDC) noted in prior studies. RS MEG and structural-MRI data were obtained from 51 ASD and 70 TDC 6- to 18-year-old males. PAF and thalamic volume maturation were observed in TDC but not ASD. Although PAF was associated with right thalamic volume in TDC (R(2)?=?0.12, p?=?0.01) but not ASD (R(2)?=?0.01, p?=?0.35), this group difference was not large enough to reach significance. Findings thus showed unusual maturation of brain function and structure in ASD as well as an across-group thalamic contribution to alpha rhythms. En ligne : http://dx.doi.org/10.1007/s10803-021-04926-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Resting-State Activity in Children: Replicating and Extending Findings of Early Maturation of Alpha Rhythms in Autism Spectrum Disorder / Guannan SHEN in Journal of Autism and Developmental Disorders, 54-5 (May 2024)  

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