Dépouillements

Psychological distress among parents of children with autism spectrum disorders: A randomized control trial of cognitive behavioural therapy / Charity Neejide ONYISHI in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102070 Titre : Psychological distress among parents of children with autism spectrum disorders: A randomized control trial of cognitive behavioural therapy Type de document : Texte imprimé et/ou numérique Auteurs : Charity Neejide ONYISHI, Auteur ; Maximus Monaheng SEFOTHO, Auteur ; Vera VICTOR-AIBODION, Auteur Article en page(s) : 102070 Langues : Anglais (eng) Mots-clés : Cognitive Behavioural Therapy  Depression  Anxiety  Stress  Autism Spectrum Disorders  Psychological distress  Parenting Index. décimale : PER Périodiques Résumé : High psychological distress that ranges from stress reactions to anxiety and depression are prevalent among parents and caregivers of children with Autism Spectrum Disorder (ASD) and undermine positive parenting and health outcomes. The current study sought to investigate cognitive-behavioral therapy (CBT) in curtailing psychological distress in a sample of those parenting children with autism. We conducted the study in Enugu state, Nigeria, with 97 parents of children with ASD. Participants were randomly allocated into CBT (N = 48) and waitlist comparison (WLC) (N = 49) groups. The CBT group participated in a 120 min CBT program weekly for 12 weeks. Data were collected using Demographic Questionnaire; Depression, Anxiety, and Stress Scale-21 items (DASS-21) and Satisfaction with therapy and therapist scale- revised (STTS-R). Three data sets were collected at baseline, post-test, and follow-up. Descriptive statistics, Repeated measures Multivariate Analysis of Variance (MANOVA), and t-test statistics were used to analyze the data. Raincloud plots were also used to illustrate results. Results revealed that all dimensions of psychological distress (DASS-depressive symptoms, DASS-anxiety, and DASS-stress) reduced significantly at post-CBT intervention and follow-up assessments in the CBT group, compared to the WLC. Multivariate analysis showed that the global psychological distress score was responsive to CBT intervention. We concluded that stress, anxiety, and depression among those parenting children with autism could be lessened with CBT. En ligne : https://doi.org/10.1016/j.rasd.2022.102070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Psychological distress among parents of children with autism spectrum disorders: A randomized control trial of cognitive behavioural therapy [Texte imprimé et/ou numérique] / Charity Neejide ONYISHI, Auteur ; Maximus Monaheng SEFOTHO, Auteur ; Vera VICTOR-AIBODION, Auteur . - 102070. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102070 Mots-clés : Cognitive Behavioural Therapy  Depression  Anxiety  Stress  Autism Spectrum Disorders  Psychological distress  Parenting Index. décimale : PER Périodiques Résumé : High psychological distress that ranges from stress reactions to anxiety and depression are prevalent among parents and caregivers of children with Autism Spectrum Disorder (ASD) and undermine positive parenting and health outcomes. The current study sought to investigate cognitive-behavioral therapy (CBT) in curtailing psychological distress in a sample of those parenting children with autism. We conducted the study in Enugu state, Nigeria, with 97 parents of children with ASD. Participants were randomly allocated into CBT (N = 48) and waitlist comparison (WLC) (N = 49) groups. The CBT group participated in a 120 min CBT program weekly for 12 weeks. Data were collected using Demographic Questionnaire; Depression, Anxiety, and Stress Scale-21 items (DASS-21) and Satisfaction with therapy and therapist scale- revised (STTS-R). Three data sets were collected at baseline, post-test, and follow-up. Descriptive statistics, Repeated measures Multivariate Analysis of Variance (MANOVA), and t-test statistics were used to analyze the data. Raincloud plots were also used to illustrate results. Results revealed that all dimensions of psychological distress (DASS-depressive symptoms, DASS-anxiety, and DASS-stress) reduced significantly at post-CBT intervention and follow-up assessments in the CBT group, compared to the WLC. Multivariate analysis showed that the global psychological distress score was responsive to CBT intervention. We concluded that stress, anxiety, and depression among those parenting children with autism could be lessened with CBT. En ligne : https://doi.org/10.1016/j.rasd.2022.102070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

How to measure camouflaging? A conceptual replication of the validation of the Camouflaging Autistic Traits Questionnaire in Dutch adults / Wikke J. VAN DER PUTTEN in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102072 Titre : How to measure camouflaging? A conceptual replication of the validation of the Camouflaging Autistic Traits Questionnaire in Dutch adults Type de document : Texte imprimé et/ou numérique Auteurs : Wikke J. VAN DER PUTTEN, Auteur ; Joost A. AGELINK VAN RENTERGEM, Auteur ; Tulsi A. RADHOE, Auteur ; Carolien TORENVLIET, Auteur ; Annabeth P. GROENMAN, Auteur ; Audrey J. J. MOL, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : 102072 Langues : Anglais (eng) Mots-clés : Camouflaging  Autism  Sex differences  Psychometric properties  Discrepancy approach Index. décimale : PER Périodiques Résumé : Background Camouflaging behavior is often defined as using strategies to hide autistic characteristics. In this study, we investigated how to measure camouflaging behavior by performing a conceptual replication of the original study of the Camouflaging Autistic Traits Questionnaire (CAT-Q) and testing whether the self-reported camouflaging behavior is measuring the same construct as the second most used manner to measure camouflaging behavior, the discrepancy method. Method In total, 674 individuals (356 autistic) aged 30 “92 years, filled out the Dutch translation of the CAT-Q (CAT-Q-NL) and the Autism Spectrum Quotient (AQ). In 90 autistic adults the Autism Diagnostic Observation Schedule (ADOS-2) was administered. We executed preregistered analyses (AsPredicted #37800) to investigate the factor structure, measurement invariance, internal consistency, convergent validity and group differences. Results Our analyses showed that the original three-factor structure had an acceptable fit and internal consistency ranged from sufficient to good. However, there was no measurement invariance between autistic and non-autistic individuals and correlations between CAT-Q-NL-scores and the discrepancy between AQ and ADOS-2 varied between low to mediocre (r = 0.04 to.28). Conclusions The CAT-Q-NL can be used to measure camouflaging between and within autistic adults, but not between autistic and non-autistic adults and its convergent validity is limited. Despite these caveats, the CAT-Q-NL can serve as a useful addition to the clinical assessment toolbox because gaining insight in the level of camouflaging of autistic adults may help provide better mental health care. However, more research is needed into how to optimally measure the camouflaging construct. En ligne : https://doi.org/10.1016/j.rasd.2022.102072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] How to measure camouflaging? A conceptual replication of the validation of the Camouflaging Autistic Traits Questionnaire in Dutch adults [Texte imprimé et/ou numérique] / Wikke J. VAN DER PUTTEN, Auteur ; Joost A. AGELINK VAN RENTERGEM, Auteur ; Tulsi A. RADHOE, Auteur ; Carolien TORENVLIET, Auteur ; Annabeth P. GROENMAN, Auteur ; Audrey J. J. MOL, Auteur ; Hilde M. GEURTS, Auteur . - 102072. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102072 Mots-clés : Camouflaging  Autism  Sex differences  Psychometric properties  Discrepancy approach Index. décimale : PER Périodiques Résumé : Background Camouflaging behavior is often defined as using strategies to hide autistic characteristics. In this study, we investigated how to measure camouflaging behavior by performing a conceptual replication of the original study of the Camouflaging Autistic Traits Questionnaire (CAT-Q) and testing whether the self-reported camouflaging behavior is measuring the same construct as the second most used manner to measure camouflaging behavior, the discrepancy method. Method In total, 674 individuals (356 autistic) aged 30 “92 years, filled out the Dutch translation of the CAT-Q (CAT-Q-NL) and the Autism Spectrum Quotient (AQ). In 90 autistic adults the Autism Diagnostic Observation Schedule (ADOS-2) was administered. We executed preregistered analyses (AsPredicted #37800) to investigate the factor structure, measurement invariance, internal consistency, convergent validity and group differences. Results Our analyses showed that the original three-factor structure had an acceptable fit and internal consistency ranged from sufficient to good. However, there was no measurement invariance between autistic and non-autistic individuals and correlations between CAT-Q-NL-scores and the discrepancy between AQ and ADOS-2 varied between low to mediocre (r = 0.04 to.28). Conclusions The CAT-Q-NL can be used to measure camouflaging between and within autistic adults, but not between autistic and non-autistic adults and its convergent validity is limited. Despite these caveats, the CAT-Q-NL can serve as a useful addition to the clinical assessment toolbox because gaining insight in the level of camouflaging of autistic adults may help provide better mental health care. However, more research is needed into how to optimally measure the camouflaging construct. En ligne : https://doi.org/10.1016/j.rasd.2022.102072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Mimicry and social affiliation with virtual partner are decreased in autism / Bahar TUNCGENC in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102073 Titre : Mimicry and social affiliation with virtual partner are decreased in autism Type de document : Texte imprimé et/ou numérique Auteurs : Bahar TUNCGENC, Auteur ; Carolyn KOCH, Auteur ; Inge-Marie EIGSTI, Auteur ; Stewart H. MOSTOFSKY, Auteur Article en page(s) : 102073 Langues : Anglais (eng) Mots-clés : Mimicry  Social affiliation  Social interactions  Autism  Children Index. décimale : PER Périodiques Résumé : Copying other people’s mannerisms (i.e., mimicry) occurs spontaneously during social interactions, and is thought to contribute to sharing emotions, affiliation with partners and interaction quality. While previous research shows decreased mimicry of emotional facial expressions in autism spectrum disorders (ASD), we know relatively little about how non-emotional, non-facial behavioural mimicry manifests and, more importantly, what it means for autistic individuals’ social interactions. In a controlled, semi-naturalistic interaction setting, this study examined how often autistic and neurotypical (NT) children mimicked a virtual partner’s non-facial mannerisms as they engaged in an interactive story-telling activity. Subsequently, children reported how affiliated they felt towards their interaction partner using an established implicit measure of closeness and a set of questions. Results revealed reduced mimicry (p = .001, φ = 0.38) and less affiliation (p = .01, φ = 0.33) in ASD relative to NT children. Mimicry was associated with affiliation for NT (r(23) = 0.64, p = .0009), but not ASD, children (r(31) = 0.07, p = .72). These results suggest an autism-associated reduction in mimicry and that mimicry during social interactions may not substantially contribute to affiliation in autism. En ligne : https://doi.org/10.1016/j.rasd.2022.102073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Mimicry and social affiliation with virtual partner are decreased in autism [Texte imprimé et/ou numérique] / Bahar TUNCGENC, Auteur ; Carolyn KOCH, Auteur ; Inge-Marie EIGSTI, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 102073. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102073 Mots-clés : Mimicry  Social affiliation  Social interactions  Autism  Children Index. décimale : PER Périodiques Résumé : Copying other people’s mannerisms (i.e., mimicry) occurs spontaneously during social interactions, and is thought to contribute to sharing emotions, affiliation with partners and interaction quality. While previous research shows decreased mimicry of emotional facial expressions in autism spectrum disorders (ASD), we know relatively little about how non-emotional, non-facial behavioural mimicry manifests and, more importantly, what it means for autistic individuals’ social interactions. In a controlled, semi-naturalistic interaction setting, this study examined how often autistic and neurotypical (NT) children mimicked a virtual partner’s non-facial mannerisms as they engaged in an interactive story-telling activity. Subsequently, children reported how affiliated they felt towards their interaction partner using an established implicit measure of closeness and a set of questions. Results revealed reduced mimicry (p = .001, φ = 0.38) and less affiliation (p = .01, φ = 0.33) in ASD relative to NT children. Mimicry was associated with affiliation for NT (r(23) = 0.64, p = .0009), but not ASD, children (r(31) = 0.07, p = .72). These results suggest an autism-associated reduction in mimicry and that mimicry during social interactions may not substantially contribute to affiliation in autism. En ligne : https://doi.org/10.1016/j.rasd.2022.102073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

A scoping review of behavioral interventions for promoting social gaze in individuals with autism spectrum disorder and other developmental disabilities / Kristin M. HUSTYI in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102074 Titre : A scoping review of behavioral interventions for promoting social gaze in individuals with autism spectrum disorder and other developmental disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Kristin M. HUSTYI, Auteur ; Alexa H. RYAN, Auteur ; Scott S. HALL, Auteur Article en page(s) : 102074 Langues : Anglais (eng) Mots-clés : Eye contact  Social gaze  Autism spectrum disorder  Developmental disabilities  Scoping review Index. décimale : PER Périodiques Résumé : Background Individuals diagnosed with autism spectrum disorder (ASD) commonly experience difficulties maintaining social gaze with others during interactions. Although behavioral interventions targeted to promote social gaze in ASD are evident in the literature, to our knowledge, no review of the literature has been conducted to summarize and evaluate the evidence for these interventions. Methods We reviewed and summarized behavioral intervention studies designed to promote social gaze in individuals diagnosed with ASD and other developmental disabilities published in English between 1977 and January 2022 using PsychINFO and PubMed databases. Results 41 studies met the inclusion criteria describing interventions conducted on 608 individuals. A variety of intervention strategies were employed to promote social gaze in these individuals including discrete trial instruction, prompting, modeling, and imitation. Most studies employed single-case research designs and reported successful outcomes, but limited data were available concerning the generalization, maintenance and social validity of these interventions. An increasing number of studies utilized technology-based procedures including computer application gameplay, gaze-contingent eye tracking devices and humanoid robots. Conclusions The present review indicates that behavioral interventions can be successfully employed to promote social gaze in individuals with ASD and other developmental disabilities. However, future research is needed to establish the generalization, maintenance and social validity of these interventions. There are also important ethical issues to be addressed given the increasing divide between treatment advocates and proponents of the neurodiversity movement. En ligne : https://doi.org/10.1016/j.rasd.2022.102074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] A scoping review of behavioral interventions for promoting social gaze in individuals with autism spectrum disorder and other developmental disabilities [Texte imprimé et/ou numérique] / Kristin M. HUSTYI, Auteur ; Alexa H. RYAN, Auteur ; Scott S. HALL, Auteur . - 102074. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102074 Mots-clés : Eye contact  Social gaze  Autism spectrum disorder  Developmental disabilities  Scoping review Index. décimale : PER Périodiques Résumé : Background Individuals diagnosed with autism spectrum disorder (ASD) commonly experience difficulties maintaining social gaze with others during interactions. Although behavioral interventions targeted to promote social gaze in ASD are evident in the literature, to our knowledge, no review of the literature has been conducted to summarize and evaluate the evidence for these interventions. Methods We reviewed and summarized behavioral intervention studies designed to promote social gaze in individuals diagnosed with ASD and other developmental disabilities published in English between 1977 and January 2022 using PsychINFO and PubMed databases. Results 41 studies met the inclusion criteria describing interventions conducted on 608 individuals. A variety of intervention strategies were employed to promote social gaze in these individuals including discrete trial instruction, prompting, modeling, and imitation. Most studies employed single-case research designs and reported successful outcomes, but limited data were available concerning the generalization, maintenance and social validity of these interventions. An increasing number of studies utilized technology-based procedures including computer application gameplay, gaze-contingent eye tracking devices and humanoid robots. Conclusions The present review indicates that behavioral interventions can be successfully employed to promote social gaze in individuals with ASD and other developmental disabilities. However, future research is needed to establish the generalization, maintenance and social validity of these interventions. There are also important ethical issues to be addressed given the increasing divide between treatment advocates and proponents of the neurodiversity movement. En ligne : https://doi.org/10.1016/j.rasd.2022.102074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Age and sex differences in problem behaviours in youth with autism spectrum disorder / Gemma GRAZIOSI in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102075 Titre : Age and sex differences in problem behaviours in youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gemma GRAZIOSI, Auteur ; Adrienne PERRY, Auteur Article en page(s) : 102075 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Problem Behaviour  Age  Sex  Developmental level Index. décimale : PER Périodiques Résumé : Background Many youth with autism spectrum disorder (ASD) display problem behaviours. Although previous studies have examined age and sex differences in problem behaviours in youth with ASD, most have done so with samples that exhibited a limited range of adaptive or intellectual functioning. This study sought to examine age and sex differences in problem behaviours in youth with ASD who were diverse in age and developmental level. Method Levels of problem behaviour, as measured by the Aberrant Behavior Checklist, were examined according to age, sex, and developmental level using data from 457 inpatients (4 “20 years old; 94 females) enrolled in the SFARI Autism Inpatient Collection. Multiple regression analyses were conducted to determine the extent to which participant characteristics predict problem behaviours. Results Age was somewhat negatively correlated with irritability and total problem behaviours and moderately negatively correlated with hyperactivity. Females exhibited significantly greater scores for irritability than males. Developmental level was negatively correlated with most problem behaviours. Age, sex, and developmental level in combination accounted for a small amount of variance in most problem behaviours. Conclusions Specific problem behaviours in youth with ASD showed some age- and sex-related differences. Higher levels of problem behaviours were also associated with lower developmental level. The generalizability of these findings may be limited due to the sample consisting exclusively of inpatients. Nonetheless, recognizing differences in levels and types of problem behaviour among youth with ASD can be useful for the development and implementation of effective intervention strategies, especially in those with lower adaptive or intellectual functioning. En ligne : https://doi.org/10.1016/j.rasd.2022.102075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Age and sex differences in problem behaviours in youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Gemma GRAZIOSI, Auteur ; Adrienne PERRY, Auteur . - 102075. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102075 Mots-clés : Autism spectrum disorder  Problem Behaviour  Age  Sex  Developmental level Index. décimale : PER Périodiques Résumé : Background Many youth with autism spectrum disorder (ASD) display problem behaviours. Although previous studies have examined age and sex differences in problem behaviours in youth with ASD, most have done so with samples that exhibited a limited range of adaptive or intellectual functioning. This study sought to examine age and sex differences in problem behaviours in youth with ASD who were diverse in age and developmental level. Method Levels of problem behaviour, as measured by the Aberrant Behavior Checklist, were examined according to age, sex, and developmental level using data from 457 inpatients (4 “20 years old; 94 females) enrolled in the SFARI Autism Inpatient Collection. Multiple regression analyses were conducted to determine the extent to which participant characteristics predict problem behaviours. Results Age was somewhat negatively correlated with irritability and total problem behaviours and moderately negatively correlated with hyperactivity. Females exhibited significantly greater scores for irritability than males. Developmental level was negatively correlated with most problem behaviours. Age, sex, and developmental level in combination accounted for a small amount of variance in most problem behaviours. Conclusions Specific problem behaviours in youth with ASD showed some age- and sex-related differences. Higher levels of problem behaviours were also associated with lower developmental level. The generalizability of these findings may be limited due to the sample consisting exclusively of inpatients. Nonetheless, recognizing differences in levels and types of problem behaviour among youth with ASD can be useful for the development and implementation of effective intervention strategies, especially in those with lower adaptive or intellectual functioning. En ligne : https://doi.org/10.1016/j.rasd.2022.102075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Screening for intellectual disability in autistic people: A brief report / Karen MCKENZIE in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102076 Titre : Screening for intellectual disability in autistic people: A brief report Type de document : Texte imprimé et/ou numérique Auteurs : Karen MCKENZIE, Auteur ; Dale METCALFE, Auteur ; Aja L. MURRAY, Auteur Article en page(s) : 102076 Langues : Anglais (eng) Mots-clés : Intellectual disability  Autism spectrum disorder  Screening  Child and adolescent intellectual disability screening questionnaire Index. décimale : PER Périodiques Résumé : Background There is high co-occurrence between intellectual disability and Autism Spectrum Disorder (ASD). It is important to identify people who have both conditions for clinical and research reasons. This study explored if the Child and Adolescent Intellectual Disability Screening Questionnaire (CAIDS-Q) and Learning Disability Screening Questionnaire (LDSQ) could accurately identify intellectual disability in autistic children and adults respectively. Method Pre-existing CAIDS-Q data for 40 autistic children and LDSQ data for 27 autistic adults were used. The participants were classified as likely to have an intellectual disability or not based on the age-appropriate cut-off score on the relevant screening tools. This was compared with their clinical diagnosis of intellectual disability. Results The sensitivity, specificity, and positive and negative predictive values, for the CAIDS-Q were 93.1 %, 88.5 %, 90 % and 92 % respectively. The corresponding figures for the LDSQ were 75 %, 95.6 %, 75 %, and 95.6 %. Conclusions The values for the CAIDS-Q were broadly consistent with figures found in previous research. The sensitivity and PPV figures for the LDSQ, were somewhat lower. The specificity and sensitivity values for both measures were above the threshold for levels that are generally considered to be acceptable for a developmental screening tool. The results suggest that the CAIDS-Q and LDSQ may be appropriate measures to screen for intellectual disability in autistic people. En ligne : https://doi.org/10.1016/j.rasd.2022.102076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Screening for intellectual disability in autistic people: A brief report [Texte imprimé et/ou numérique] / Karen MCKENZIE, Auteur ; Dale METCALFE, Auteur ; Aja L. MURRAY, Auteur . - 102076. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102076 Mots-clés : Intellectual disability  Autism spectrum disorder  Screening  Child and adolescent intellectual disability screening questionnaire Index. décimale : PER Périodiques Résumé : Background There is high co-occurrence between intellectual disability and Autism Spectrum Disorder (ASD). It is important to identify people who have both conditions for clinical and research reasons. This study explored if the Child and Adolescent Intellectual Disability Screening Questionnaire (CAIDS-Q) and Learning Disability Screening Questionnaire (LDSQ) could accurately identify intellectual disability in autistic children and adults respectively. Method Pre-existing CAIDS-Q data for 40 autistic children and LDSQ data for 27 autistic adults were used. The participants were classified as likely to have an intellectual disability or not based on the age-appropriate cut-off score on the relevant screening tools. This was compared with their clinical diagnosis of intellectual disability. Results The sensitivity, specificity, and positive and negative predictive values, for the CAIDS-Q were 93.1 %, 88.5 %, 90 % and 92 % respectively. The corresponding figures for the LDSQ were 75 %, 95.6 %, 75 %, and 95.6 %. Conclusions The values for the CAIDS-Q were broadly consistent with figures found in previous research. The sensitivity and PPV figures for the LDSQ, were somewhat lower. The specificity and sensitivity values for both measures were above the threshold for levels that are generally considered to be acceptable for a developmental screening tool. The results suggest that the CAIDS-Q and LDSQ may be appropriate measures to screen for intellectual disability in autistic people. En ligne : https://doi.org/10.1016/j.rasd.2022.102076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Mortality rate and age of death among Medicare-enrolled autistic older adults / Morgan KRANTZ in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102077 Titre : Mortality rate and age of death among Medicare-enrolled autistic older adults Type de document : Texte imprimé et/ou numérique Auteurs : Morgan KRANTZ, Auteur ; Djhenne DALMACY, Auteur ; Lauren BISHOP, Auteur ; J. Madison HYER, Auteur ; Brittany N. HAND, Auteur Article en page(s) : 102077 Langues : Anglais (eng) Mots-clés : Autism  Older adulthood  Survival  Mortality Index. décimale : PER Périodiques Résumé : Background An emerging body of evidence suggests that autistic people are at greater risk for mortality than non-autistic people. Yet, relatively little is known about mortality rates among autistic people during older adulthood (i.e., age 65 or older). Methods We examined 5-year mortality among a national US sample of Medicare-enrolled autistic (n = 3308) and non-autistic (n = 33,080) adults aged 65 or older. Results Autistic older adults had 2.87 times greater rate of mortality (95 % CI = 2.61 “3.07) than non-autistic older adults. Among decedents (39.6 % of autistic and 15.1 % of non-autistic older adults), the median age of death was 72 years (IQR = 69 “78) for autistic and 75 years (IQR=70 “83) for non-autistic older adults. Among autistic older adults, those with intellectual disability had 1.57 times greater rate of mortality (95 % CI = 1.41 “1.76) than those without, and males had 1.27 times greater rate of mortality (95 % CI = 1.12 “1.43) than females. Conclusions Many trends regarding mortality observed in younger samples of autistic people were also observed in our study. However, we found only a three-year difference in median age at death between autistic and non-autistic decedents, which is a much smaller disparity than reported in some other studies. This potentially suggests that when autistic people live to the age of 65, they may live to a more similar age as non-autistic peers. En ligne : https://doi.org/10.1016/j.rasd.2022.102077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Mortality rate and age of death among Medicare-enrolled autistic older adults [Texte imprimé et/ou numérique] / Morgan KRANTZ, Auteur ; Djhenne DALMACY, Auteur ; Lauren BISHOP, Auteur ; J. Madison HYER, Auteur ; Brittany N. HAND, Auteur . - 102077. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102077 Mots-clés : Autism  Older adulthood  Survival  Mortality Index. décimale : PER Périodiques Résumé : Background An emerging body of evidence suggests that autistic people are at greater risk for mortality than non-autistic people. Yet, relatively little is known about mortality rates among autistic people during older adulthood (i.e., age 65 or older). Methods We examined 5-year mortality among a national US sample of Medicare-enrolled autistic (n = 3308) and non-autistic (n = 33,080) adults aged 65 or older. Results Autistic older adults had 2.87 times greater rate of mortality (95 % CI = 2.61 “3.07) than non-autistic older adults. Among decedents (39.6 % of autistic and 15.1 % of non-autistic older adults), the median age of death was 72 years (IQR = 69 “78) for autistic and 75 years (IQR=70 “83) for non-autistic older adults. Among autistic older adults, those with intellectual disability had 1.57 times greater rate of mortality (95 % CI = 1.41 “1.76) than those without, and males had 1.27 times greater rate of mortality (95 % CI = 1.12 “1.43) than females. Conclusions Many trends regarding mortality observed in younger samples of autistic people were also observed in our study. However, we found only a three-year difference in median age at death between autistic and non-autistic decedents, which is a much smaller disparity than reported in some other studies. This potentially suggests that when autistic people live to the age of 65, they may live to a more similar age as non-autistic peers. En ligne : https://doi.org/10.1016/j.rasd.2022.102077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Mitochondrial DNA involvement in patients with autism spectrum disorders and intellectual disability / Carmela SCUDERI in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102084 Titre : Mitochondrial DNA involvement in patients with autism spectrum disorders and intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Carmela SCUDERI, Auteur ; Sandro SANTA PAOLA, Auteur ; Mariangela LO GIUDICE, Auteur ; Francesco Domenico DI BLASI, Auteur ; Stefania GIUSTO, Auteur ; Giuseppa DI VITA, Auteur ; Rosa PETTINATO, Auteur ; Girolamo Aurelio VITELLO, Auteur ; Corrado ROMANO, Auteur ; Serafino BUONO, Auteur ; Vincenzo SALPIETRO, Auteur ; Henry HOULDEN, Auteur ; Eugenia BORGIONE, Auteur Article en page(s) : 102084 Langues : Anglais (eng) Mots-clés : Autism  Intellectual disability  MtDNA  Mitochondrial disease Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) are neurodevelopmental disorders, with heterogeneous etiology, characterized by deficiencies in social interaction, communication, and by repetitive and stereotyped behaviors. Mitochondrial encephalomyopathies are inherited disorders of oxidative metabolism, with a wide clinical, biochemical and genetic heterogeneity, requiring a complex diagnostic flow-chart. Infantile forms often occur with defects in development, intellectual disabilities and dysmorphisms. ASD has been associated with mitochondrial respiratory chain deficiency and/or mitochondrial DNA (mtDNA) mutations. However, few studies carried out detailed clinical, instrumental, morphological, biochemical investigations, and mtDNA sequencing in ASD patients. Method The purpose of this study was the identification of mitochondrial dysfunction due to mtDNA variants in 19 selected subjects presenting ASD and clinical features of mitochondrial disease. For these patients we adopted a multidisciplinary approach combining clinical and laboratory investigations on muscle biopsy, with biochemical, histological and genetic techniques. Results The histological examination showed myogenic or neurogenic changes in 79 % of patients; furthermore, 58 % of the patients had lipid accumulation, mitochondrial proliferation and COX deficient fibers. The biochemical investigations reported in three patients impairments involving one or more of the respiratory chain complexes. In addition, genetic studies revealed in one patient with normal histology and biochemistry multiple mtDNA deletions, and in four patients different mtDNA point mutations. Conclusions The present study confirms the hypothesis of an association between ASD and mitochondrial dysfunction. However, further studies in a larger group of subjects are needed. En ligne : https://doi.org/10.1016/j.rasd.2022.102084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Mitochondrial DNA involvement in patients with autism spectrum disorders and intellectual disability [Texte imprimé et/ou numérique] / Carmela SCUDERI, Auteur ; Sandro SANTA PAOLA, Auteur ; Mariangela LO GIUDICE, Auteur ; Francesco Domenico DI BLASI, Auteur ; Stefania GIUSTO, Auteur ; Giuseppa DI VITA, Auteur ; Rosa PETTINATO, Auteur ; Girolamo Aurelio VITELLO, Auteur ; Corrado ROMANO, Auteur ; Serafino BUONO, Auteur ; Vincenzo SALPIETRO, Auteur ; Henry HOULDEN, Auteur ; Eugenia BORGIONE, Auteur . - 102084. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102084 Mots-clés : Autism  Intellectual disability  MtDNA  Mitochondrial disease Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) are neurodevelopmental disorders, with heterogeneous etiology, characterized by deficiencies in social interaction, communication, and by repetitive and stereotyped behaviors. Mitochondrial encephalomyopathies are inherited disorders of oxidative metabolism, with a wide clinical, biochemical and genetic heterogeneity, requiring a complex diagnostic flow-chart. Infantile forms often occur with defects in development, intellectual disabilities and dysmorphisms. ASD has been associated with mitochondrial respiratory chain deficiency and/or mitochondrial DNA (mtDNA) mutations. However, few studies carried out detailed clinical, instrumental, morphological, biochemical investigations, and mtDNA sequencing in ASD patients. Method The purpose of this study was the identification of mitochondrial dysfunction due to mtDNA variants in 19 selected subjects presenting ASD and clinical features of mitochondrial disease. For these patients we adopted a multidisciplinary approach combining clinical and laboratory investigations on muscle biopsy, with biochemical, histological and genetic techniques. Results The histological examination showed myogenic or neurogenic changes in 79 % of patients; furthermore, 58 % of the patients had lipid accumulation, mitochondrial proliferation and COX deficient fibers. The biochemical investigations reported in three patients impairments involving one or more of the respiratory chain complexes. In addition, genetic studies revealed in one patient with normal histology and biochemistry multiple mtDNA deletions, and in four patients different mtDNA point mutations. Conclusions The present study confirms the hypothesis of an association between ASD and mitochondrial dysfunction. However, further studies in a larger group of subjects are needed. En ligne : https://doi.org/10.1016/j.rasd.2022.102084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Heterogeneity and imbalance of reading profiles in Autism Spectrum Disorders / Juan LIU in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102088 Titre : Heterogeneity and imbalance of reading profiles in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Juan LIU, Auteur ; Ying WANG, Auteur ; Li YI, Auteur Article en page(s) : 102088 Langues : Anglais (eng) Mots-clés : Hyperlexia  Word decoding  Listening comprehension  Morphological awareness  Orthographic awareness Index. décimale : PER Périodiques Résumé : This study aimed to identify distinct reading profiles in 4 “11-year-old Chinese autistic and neurotypical (NT) children and to examine the unique characteristics of each group. Forty-five autistic children and 45 NT comparisons matched on nonverbal IQ and age were assessed in a comprehensive reading battery including word reading, listening comprehension, and reading-related language skills. Using latent profile analysis, four reading profiles of autistic children emerged: readers with good decoding and listening comprehension skills (GDGL, 33.3 %), good decoders with poor listening comprehension skills (GDPL, 35.7 %), readers with average decoding and listening comprehension skills (ADAL, 20 %), and readers with poor decoding and listening comprehension skills (PDPL, 20 %). Furthermore, the results indicated an imbalanced pattern of reading profiles with over 50 % of autistic children performing well in certain reading abilities but poorly in other skills. The findings highlight the urgent need for designing individualized reading supports for autistic children. En ligne : https://doi.org/10.1016/j.rasd.2022.102088 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Heterogeneity and imbalance of reading profiles in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Juan LIU, Auteur ; Ying WANG, Auteur ; Li YI, Auteur . - 102088. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102088 Mots-clés : Hyperlexia  Word decoding  Listening comprehension  Morphological awareness  Orthographic awareness Index. décimale : PER Périodiques Résumé : This study aimed to identify distinct reading profiles in 4 “11-year-old Chinese autistic and neurotypical (NT) children and to examine the unique characteristics of each group. Forty-five autistic children and 45 NT comparisons matched on nonverbal IQ and age were assessed in a comprehensive reading battery including word reading, listening comprehension, and reading-related language skills. Using latent profile analysis, four reading profiles of autistic children emerged: readers with good decoding and listening comprehension skills (GDGL, 33.3 %), good decoders with poor listening comprehension skills (GDPL, 35.7 %), readers with average decoding and listening comprehension skills (ADAL, 20 %), and readers with poor decoding and listening comprehension skills (PDPL, 20 %). Furthermore, the results indicated an imbalanced pattern of reading profiles with over 50 % of autistic children performing well in certain reading abilities but poorly in other skills. The findings highlight the urgent need for designing individualized reading supports for autistic children. En ligne : https://doi.org/10.1016/j.rasd.2022.102088 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491