Dépouillements

Factor Structure and Psychometric Properties of the BIS/BAS Scales in Children and Adolescents With Autism / Lacey CHETCUTI in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70171 Titre : Factor Structure and Psychometric Properties of the BIS/BAS Scales in Children and Adolescents With Autism Type de document : texte imprimé Auteurs : Lacey CHETCUTI, Auteur ; Antonio HARDAN, Auteur ; Emily SPACKMAN, Auteur ; Luke SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Mirko ULJAREVIĆ, Auteur Article en page(s) : e70171 Langues : Anglais (eng) Mots-clés : autism  behavioral activation  behavioral avoidance  factor analysis  measurement invariance  psychometrics  reward sensitivity theory Index. décimale : PER Périodiques Résumé : ABSTRACT The Behavioral Inhibition System and Behavioral Activation System (BIS/BAS) Scales offer a framework for assessing individual differences in sensitivity to reward and punishment?processes theorized to underlie key autism features. Despite widespread use, the psychometric properties of the BIS/BAS Scales have yet to be evaluated in the autistic population. Therefore, this study sought to evaluate the factor structure and psychometric properties of the BIS/BAS Scales in a sample of children and adolescents with autism. Parents of N?=?709 autistic youth (Mage [SD]?=?11.22?years [3.54]; 75% male) completed the BIS/BAS Scales alongside additional convergent/divergent validity measures. Factor structures ranging from one to eight specific factors were tested, including bifactor and hierarchical models with and without general factors. Measurement invariance was assessed across age groups ( En ligne : https://doi.org/10.1002/aur.70171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Factor Structure and Psychometric Properties of the BIS/BAS Scales in Children and Adolescents With Autism [texte imprimé] / Lacey CHETCUTI, Auteur ; Antonio HARDAN, Auteur ; Emily SPACKMAN, Auteur ; Luke SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Mirko ULJAREVIĆ, Auteur . - e70171. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70171 Mots-clés : autism  behavioral activation  behavioral avoidance  factor analysis  measurement invariance  psychometrics  reward sensitivity theory Index. décimale : PER Périodiques Résumé : ABSTRACT The Behavioral Inhibition System and Behavioral Activation System (BIS/BAS) Scales offer a framework for assessing individual differences in sensitivity to reward and punishment?processes theorized to underlie key autism features. Despite widespread use, the psychometric properties of the BIS/BAS Scales have yet to be evaluated in the autistic population. Therefore, this study sought to evaluate the factor structure and psychometric properties of the BIS/BAS Scales in a sample of children and adolescents with autism. Parents of N?=?709 autistic youth (Mage [SD]?=?11.22?years [3.54]; 75% male) completed the BIS/BAS Scales alongside additional convergent/divergent validity measures. Factor structures ranging from one to eight specific factors were tested, including bifactor and hierarchical models with and without general factors. Measurement invariance was assessed across age groups ( En ligne : https://doi.org/10.1002/aur.70171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Bilingualism Enhances Metalinguistic Awareness in Autism: Extending the Two-Dimensional Grammaticality Judgment Task / Pauline WOLFER in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70173 Titre : Bilingualism Enhances Metalinguistic Awareness in Autism: Extending the Two-Dimensional Grammaticality Judgment Task Type de document : texte imprimé Auteurs : Pauline WOLFER, Auteur ; Franziska BAUMEISTER, Auteur ; Stephanie DURRLEMAN, Auteur Article en page(s) : e70173 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  bilingualism  grammaticality judgment task  metalinguistic awareness Index. décimale : PER Périodiques Résumé : ABSTRACT Bilingualism has been associated with enhanced metalinguistic awareness (MA), the ability to reflect upon language. However, findings remain mixed, and little is known about how proficiency in the most proficient (L1) and second-best language (L2) contribute to MA, especially in children with autism spectrum disorder (ASD), who often present heterogeneous cognitive and linguistic profiles. We tested 270 children aged 5?12 (90 autistic, 180 neurotypical) using a two-dimensional Grammaticality Judgment Task (GJT) requiring two components of MA: analyzed knowledge (understanding of grammatical rules) and cognitive control (suppressing irrelevant semantic cues). Bilingualism was examined both categorically (monolingual vs. bilingual) and continuously (L2 proficiency), using generalized linear mixed-effects models controlling for age, nonverbal IQ, and L1 proficiency. Among neurotypical children, no significant bilingual advantage was found. In contrast, bilingual autistic children significantly outperformed monolingual peers on items requiring cognitive control, and higher L2 proficiency was associated with better overall GJT performance. These findings advance understanding of how bilingualism relates to metalinguistic abilities in autism and suggest that it is not only non-detrimental but may confer specific metalinguistic benefits. The study underscores the importance of combining categorical and continuous approaches to bilingualism to better capture individual variability in neurodiverse populations. En ligne : https://doi.org/10.1002/aur.70173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Bilingualism Enhances Metalinguistic Awareness in Autism: Extending the Two-Dimensional Grammaticality Judgment Task [texte imprimé] / Pauline WOLFER, Auteur ; Franziska BAUMEISTER, Auteur ; Stephanie DURRLEMAN, Auteur . - e70173. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70173 Mots-clés : autism spectrum disorder  bilingualism  grammaticality judgment task  metalinguistic awareness Index. décimale : PER Périodiques Résumé : ABSTRACT Bilingualism has been associated with enhanced metalinguistic awareness (MA), the ability to reflect upon language. However, findings remain mixed, and little is known about how proficiency in the most proficient (L1) and second-best language (L2) contribute to MA, especially in children with autism spectrum disorder (ASD), who often present heterogeneous cognitive and linguistic profiles. We tested 270 children aged 5?12 (90 autistic, 180 neurotypical) using a two-dimensional Grammaticality Judgment Task (GJT) requiring two components of MA: analyzed knowledge (understanding of grammatical rules) and cognitive control (suppressing irrelevant semantic cues). Bilingualism was examined both categorically (monolingual vs. bilingual) and continuously (L2 proficiency), using generalized linear mixed-effects models controlling for age, nonverbal IQ, and L1 proficiency. Among neurotypical children, no significant bilingual advantage was found. In contrast, bilingual autistic children significantly outperformed monolingual peers on items requiring cognitive control, and higher L2 proficiency was associated with better overall GJT performance. These findings advance understanding of how bilingualism relates to metalinguistic abilities in autism and suggest that it is not only non-detrimental but may confer specific metalinguistic benefits. The study underscores the importance of combining categorical and continuous approaches to bilingualism to better capture individual variability in neurodiverse populations. En ligne : https://doi.org/10.1002/aur.70173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Cognitive and Affective Predictors of Restricted and Repetitive Behaviors and Interests in Very Young Autistic Children / Nasim SHEIKHI in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70175 Titre : Cognitive and Affective Predictors of Restricted and Repetitive Behaviors and Interests in Very Young Autistic Children Type de document : texte imprimé Auteurs : Nasim SHEIKHI, Auteur ; Gina SCHNUR, Auteur ; Susan FAJA, Auteur Article en page(s) : e70175 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  child development  executive function  mental health  repetitive behavior  temperament Index. décimale : PER Périodiques Résumé : ABSTRACT The development of distinct restricted and repetitive behaviors and interests (RRBIs) is well-studied in autism, but their relationship to cognitive and affective development in young autistic children is unknown. This cross-sectional study examined how higher-order RRBIs (e.g., circumscribed interests and insistence on sameness) and sensorimotor RRBIs (e.g., stereotyped movements and sensory preoccupations) relate to concurrent developmental level, executive function, temperament, and internalizing and externalizing behaviors in autistic toddlers and preschoolers. 143 2- and 4-year-old autistic children with developmental levels of at least 12?months completed a battery of executive function tasks, and caregivers completed interviews and questionnaires regarding their children's autistic features and affective functioning. Higher-order RRBIs, but not sensorimotor RRBIs, were related to age and developmental level. In the 2-year cohort, discomfort and executive function related to higher-order RRBIs, as well. Hyperactivity related to sensorimotor RRBIs in both cohorts, and discomfort also related to sensorimotor RRBIs in the 4-year-olds. These findings suggest that temperamental markers and features of mental health conditions may contribute to the expression of distinct RRBI subdomains. Child cognitive capacity may also underlie parental ability to report on RRBIs for young children. This study highlights the importance of distinguishing RRBI subdomains in young autistic children due to their distinct relationships to functioning and wellbeing. En ligne : https://doi.org/10.1002/aur.70175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Cognitive and Affective Predictors of Restricted and Repetitive Behaviors and Interests in Very Young Autistic Children [texte imprimé] / Nasim SHEIKHI, Auteur ; Gina SCHNUR, Auteur ; Susan FAJA, Auteur . - e70175. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70175 Mots-clés : autism spectrum disorder  child development  executive function  mental health  repetitive behavior  temperament Index. décimale : PER Périodiques Résumé : ABSTRACT The development of distinct restricted and repetitive behaviors and interests (RRBIs) is well-studied in autism, but their relationship to cognitive and affective development in young autistic children is unknown. This cross-sectional study examined how higher-order RRBIs (e.g., circumscribed interests and insistence on sameness) and sensorimotor RRBIs (e.g., stereotyped movements and sensory preoccupations) relate to concurrent developmental level, executive function, temperament, and internalizing and externalizing behaviors in autistic toddlers and preschoolers. 143 2- and 4-year-old autistic children with developmental levels of at least 12?months completed a battery of executive function tasks, and caregivers completed interviews and questionnaires regarding their children's autistic features and affective functioning. Higher-order RRBIs, but not sensorimotor RRBIs, were related to age and developmental level. In the 2-year cohort, discomfort and executive function related to higher-order RRBIs, as well. Hyperactivity related to sensorimotor RRBIs in both cohorts, and discomfort also related to sensorimotor RRBIs in the 4-year-olds. These findings suggest that temperamental markers and features of mental health conditions may contribute to the expression of distinct RRBI subdomains. Child cognitive capacity may also underlie parental ability to report on RRBIs for young children. This study highlights the importance of distinguishing RRBI subdomains in young autistic children due to their distinct relationships to functioning and wellbeing. En ligne : https://doi.org/10.1002/aur.70175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Spontaneous Play Profiles in Mandarin-Speaking Preschool Children With Autism, Developmental Delay, and Typical Development: A Fine-Grained Comparative Analysis / Tongxin YIN in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70178 Titre : Spontaneous Play Profiles in Mandarin-Speaking Preschool Children With Autism, Developmental Delay, and Typical Development: A Fine-Grained Comparative Analysis Type de document : texte imprimé Auteurs : Tongxin YIN, Auteur ; Min LIU, Auteur ; Jie WANG, Auteur ; Xuling HAN, Auteur ; Yanxia WANG, Auteur ; Xinyu HU, Auteur ; Yuran LUO, Auteur ; Ziying DENG, Auteur ; Mudi SUN, Auteur ; Lu QU, Auteur ; Saige QIN, Auteur ; Haidan LU, Auteur ; Qiaoyun LIU, Auteur ; Hang ZHAO, Auteur Article en page(s) : e70178 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  child  developmental delay  spontaneous play  symbolic Index. décimale : PER Périodiques Résumé : ABSTRACT This study examined the spontaneous play behaviors of Mandarin-speaking preschool children with autism spectrum disorder (ASD), developmental delay (DD), and typical development (TD) during naturalistic parent?child interactions. Ninety children aged 36?72?months (30 per group) participated in a 15-min parent?child free-play session, and a standardized 10-min segment from each session (minutes 3?13) was coded and analyzed. Play behaviors were coded using a fine-grained developmental framework and analyzed using both unidimensional (duration and frequency) and multidimensional (variety, highest mastered play level and weighted average mastered play levels) indicators. After adjusting for FSIQ, spontaneous play duration (F(2, 86)?=?14.54, p? En ligne : https://doi.org/10.1002/aur.70178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Spontaneous Play Profiles in Mandarin-Speaking Preschool Children With Autism, Developmental Delay, and Typical Development: A Fine-Grained Comparative Analysis [texte imprimé] / Tongxin YIN, Auteur ; Min LIU, Auteur ; Jie WANG, Auteur ; Xuling HAN, Auteur ; Yanxia WANG, Auteur ; Xinyu HU, Auteur ; Yuran LUO, Auteur ; Ziying DENG, Auteur ; Mudi SUN, Auteur ; Lu QU, Auteur ; Saige QIN, Auteur ; Haidan LU, Auteur ; Qiaoyun LIU, Auteur ; Hang ZHAO, Auteur . - e70178. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70178 Mots-clés : autism spectrum disorder  child  developmental delay  spontaneous play  symbolic Index. décimale : PER Périodiques Résumé : ABSTRACT This study examined the spontaneous play behaviors of Mandarin-speaking preschool children with autism spectrum disorder (ASD), developmental delay (DD), and typical development (TD) during naturalistic parent?child interactions. Ninety children aged 36?72?months (30 per group) participated in a 15-min parent?child free-play session, and a standardized 10-min segment from each session (minutes 3?13) was coded and analyzed. Play behaviors were coded using a fine-grained developmental framework and analyzed using both unidimensional (duration and frequency) and multidimensional (variety, highest mastered play level and weighted average mastered play levels) indicators. After adjusting for FSIQ, spontaneous play duration (F(2, 86)?=?14.54, p? En ligne : https://doi.org/10.1002/aur.70178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Machine Learning-Based Early Prediction Model for Autism Spectrum Disorder in Infants Using Acoustic Feature / Shengjian YIN in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70179 Titre : Machine Learning-Based Early Prediction Model for Autism Spectrum Disorder in Infants Using Acoustic Feature Type de document : texte imprimé Auteurs : Shengjian YIN, Auteur ; Zhijia LI, Auteur ; Luyang GUAN, Auteur ; Zenghe YUE, Auteur ; Jincen WANG, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Qian LI, Auteur ; Lan LIN, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Yun LI, Auteur ; Xiaoyan KE, Auteur Article en page(s) : e70179 Langues : Anglais (eng) Mots-clés : acoustic features  autism spectrum disorder  machine learning  model  support vector machine Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to create a machine learning-based predictive model for early detection of autism spectrum disorder (ASD) in infants using acoustic features. Conducted as a prospective cohort at Nanjing Medical University from 2019 to 2024, infants aged 9?18?months from an ASD sibling cohort participated. Behavioral and vocalization data were gathered during the Still-Face Paradigm, with ASD diagnoses confirmed at 36?months through ADOS and ADI-R assessments. Researchers extracted 4368 acoustic features from the recordings and applied LASSO regression for dimensionality reduction, identifying 39 key features. A support vector machine (SVM) classifier was then developed, tested with four kernel functions?linear, radial basis function, polynomial, and sigmoid?via tenfold cross-validation. The final sample included 88 infants, 28 of whom were diagnosed with ASD. The sigmoid kernel yielded the best results, achieving a 92.86% sensitivity, 93.33% specificity, and a 93.18% accuracy. Notably, spectral and energy-related features were significantly higher in ASD infants (p? En ligne : https://doi.org/10.1002/aur.70179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Machine Learning-Based Early Prediction Model for Autism Spectrum Disorder in Infants Using Acoustic Feature [texte imprimé] / Shengjian YIN, Auteur ; Zhijia LI, Auteur ; Luyang GUAN, Auteur ; Zenghe YUE, Auteur ; Jincen WANG, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Qian LI, Auteur ; Lan LIN, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Yun LI, Auteur ; Xiaoyan KE, Auteur . - e70179. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70179 Mots-clés : acoustic features  autism spectrum disorder  machine learning  model  support vector machine Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to create a machine learning-based predictive model for early detection of autism spectrum disorder (ASD) in infants using acoustic features. Conducted as a prospective cohort at Nanjing Medical University from 2019 to 2024, infants aged 9?18?months from an ASD sibling cohort participated. Behavioral and vocalization data were gathered during the Still-Face Paradigm, with ASD diagnoses confirmed at 36?months through ADOS and ADI-R assessments. Researchers extracted 4368 acoustic features from the recordings and applied LASSO regression for dimensionality reduction, identifying 39 key features. A support vector machine (SVM) classifier was then developed, tested with four kernel functions?linear, radial basis function, polynomial, and sigmoid?via tenfold cross-validation. The final sample included 88 infants, 28 of whom were diagnosed with ASD. The sigmoid kernel yielded the best results, achieving a 92.86% sensitivity, 93.33% specificity, and a 93.18% accuracy. Notably, spectral and energy-related features were significantly higher in ASD infants (p? En ligne : https://doi.org/10.1002/aur.70179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Reduced Hand Specialization and Idiosyncratic Visuomotor Strategies in Autism During Naturalistic Object Manipulation / Emily FEWSTER in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70180 Titre : Reduced Hand Specialization and Idiosyncratic Visuomotor Strategies in Autism During Naturalistic Object Manipulation Type de document : texte imprimé Auteurs : Emily FEWSTER, Auteur ; Bat-Sheva HADAD, Auteur ; Erez FREUD, Auteur Article en page(s) : e70180 Langues : Anglais (eng) Mots-clés : grasping  handedness  lateralization  specilization   visuomotor control Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals exhibit altered perceptual and visuomotor behaviors, potentially due to reduced cortical specialization. The current study focuses on handedness, a robust marker of cerebral specialization, which is less right-biased in autism. Previous studies have typically assessed handedness via questionnaires or simple manual tasks that do not characterize the dynamic, on-going nature of real-life actions. To address this gap, autistic and non-autistic right-handed adults recreated LEGO models from blocks placed on a standardized tabletop, enabling analysis of dynamic, real-world visuomotor behaviors. Autistic participants displayed a lower proportion of right-hand grasps and fewer contralateral movements (i.e., crossing the body midline) with their right hand. Additionally, we observed differences in 3D space utilization, such that autistic participants exhibited a stronger preference for blocks placed closer to their hands. Finally, autistic participants were slower, and their movement trajectories were more idiosyncratic when compared with non-autistic participants. These results reveal reduced hand specialization and profound visuomotor control differences in autism, highlighting potential clinical utility for early, objective autism markers. En ligne : https://doi.org/10.1002/aur.70180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Reduced Hand Specialization and Idiosyncratic Visuomotor Strategies in Autism During Naturalistic Object Manipulation [texte imprimé] / Emily FEWSTER, Auteur ; Bat-Sheva HADAD, Auteur ; Erez FREUD, Auteur . - e70180. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70180 Mots-clés : grasping  handedness  lateralization  specilization   visuomotor control Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals exhibit altered perceptual and visuomotor behaviors, potentially due to reduced cortical specialization. The current study focuses on handedness, a robust marker of cerebral specialization, which is less right-biased in autism. Previous studies have typically assessed handedness via questionnaires or simple manual tasks that do not characterize the dynamic, on-going nature of real-life actions. To address this gap, autistic and non-autistic right-handed adults recreated LEGO models from blocks placed on a standardized tabletop, enabling analysis of dynamic, real-world visuomotor behaviors. Autistic participants displayed a lower proportion of right-hand grasps and fewer contralateral movements (i.e., crossing the body midline) with their right hand. Additionally, we observed differences in 3D space utilization, such that autistic participants exhibited a stronger preference for blocks placed closer to their hands. Finally, autistic participants were slower, and their movement trajectories were more idiosyncratic when compared with non-autistic participants. These results reveal reduced hand specialization and profound visuomotor control differences in autism, highlighting potential clinical utility for early, objective autism markers. En ligne : https://doi.org/10.1002/aur.70180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Cerebrospinal Fluid Vasopressin Concentration Is a Biomarker of Autistic Social Impairment and Hypothalamic Vasopressin Gene Expression in Humans / Ozge OZTAN in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70181 Titre : Cerebrospinal Fluid Vasopressin Concentration Is a Biomarker of Autistic Social Impairment and Hypothalamic Vasopressin Gene Expression in Humans Type de document : texte imprimé Auteurs : Ozge OZTAN, Auteur ; Chunfang ZHU, Auteur ; Duyen K. K. NGUYEN, Auteur ; Robert B. WEST, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur Article en page(s) : e70181 Langues : Anglais (eng) Mots-clés : arginine vasopressin  autism spectrum disorder  cerebrospinal fluid  hypothalamus  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social interaction difficulties and restricted, repetitive behaviors. Recent ASD biomarker discovery efforts have found that cerebrospinal fluid (CSF) concentration of vasopressin, a hypothalamic neuropeptide critical for mammalian social functioning, is significantly lower in children with ASD and newborns later diagnosed with ASD. Low CSF vasopressin concentration is also linked to ASD social (but not repetitive) behavior symptom severity. These findings suggest that CSF vasopressin measurement may have clinical utility, but CSF surveillance requires invasive sampling procedures that will be difficult to integrate into routine clinical care without strong justification (i.e., CSF vasopressin is a valid proxy for hypothalamic vasopressin production, whereas blood vasopressin is not). We therefore obtained neuropathological specimens and patient data (N?=?18) to investigate this possibility. In Study 1, we capitalized on the unique opportunity to test the reproducibility and robustness of the relationship between CSF vasopressin concentration and ASD behavioral symptoms in a sample demographically and methodologically distinct from prior work. This relationship held across age, antemortem to postmortem biospecimens, quantification platforms, clinical instruments, evaluators, and symptom type. In Study 2, we found in concomitantly collected postmortem samples that CSF vasopressin concentration significantly and positively predicted hypothalamic vasopressin gene expression, whereas blood vasopressin concentration did not. These findings establish CSF vasopressin as a brain-derived, mechanistically relevant biomarker of social difficulties in ASD, and suggest that CSF vasopressin measurement may be useful for ASD detection and/or identification of individuals who will benefit from pharmacological enhancement of brain vasopressin signaling. En ligne : https://doi.org/10.1002/aur.70181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Cerebrospinal Fluid Vasopressin Concentration Is a Biomarker of Autistic Social Impairment and Hypothalamic Vasopressin Gene Expression in Humans [texte imprimé] / Ozge OZTAN, Auteur ; Chunfang ZHU, Auteur ; Duyen K. K. NGUYEN, Auteur ; Robert B. WEST, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur . - e70181. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70181 Mots-clés : arginine vasopressin  autism spectrum disorder  cerebrospinal fluid  hypothalamus  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social interaction difficulties and restricted, repetitive behaviors. Recent ASD biomarker discovery efforts have found that cerebrospinal fluid (CSF) concentration of vasopressin, a hypothalamic neuropeptide critical for mammalian social functioning, is significantly lower in children with ASD and newborns later diagnosed with ASD. Low CSF vasopressin concentration is also linked to ASD social (but not repetitive) behavior symptom severity. These findings suggest that CSF vasopressin measurement may have clinical utility, but CSF surveillance requires invasive sampling procedures that will be difficult to integrate into routine clinical care without strong justification (i.e., CSF vasopressin is a valid proxy for hypothalamic vasopressin production, whereas blood vasopressin is not). We therefore obtained neuropathological specimens and patient data (N?=?18) to investigate this possibility. In Study 1, we capitalized on the unique opportunity to test the reproducibility and robustness of the relationship between CSF vasopressin concentration and ASD behavioral symptoms in a sample demographically and methodologically distinct from prior work. This relationship held across age, antemortem to postmortem biospecimens, quantification platforms, clinical instruments, evaluators, and symptom type. In Study 2, we found in concomitantly collected postmortem samples that CSF vasopressin concentration significantly and positively predicted hypothalamic vasopressin gene expression, whereas blood vasopressin concentration did not. These findings establish CSF vasopressin as a brain-derived, mechanistically relevant biomarker of social difficulties in ASD, and suggest that CSF vasopressin measurement may be useful for ASD detection and/or identification of individuals who will benefit from pharmacological enhancement of brain vasopressin signaling. En ligne : https://doi.org/10.1002/aur.70181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Clarifying the ABA Comparison and Equivalence Claims in Schaaf et al. () / Wen-Pin CHANG in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70184 Titre : Clarifying the ABA Comparison and Equivalence Claims in Schaaf et al. () Type de document : texte imprimé Auteurs : Wen-Pin CHANG, Auteur Article en page(s) : e70184 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Clarifying the ABA Comparison and Equivalence Claims in Schaaf et al. () [texte imprimé] / Wen-Pin CHANG, Auteur . - e70184. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70184 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Examining the Relationship Between Social Motivation and Internalizing Symptoms in Autistic People: A Systematic Review and Meta-Analysis / Katie LINDSAY-WEBB in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70185 Titre : Examining the Relationship Between Social Motivation and Internalizing Symptoms in Autistic People: A Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Katie LINDSAY-WEBB, Auteur ; Poppy CLAYTON, Auteur ; Emily SIMONOFF, Auteur ; Matthew J. HOLLOCKS, Auteur Article en page(s) : e70185 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT The social motivation theory hypothesizes that autistic individuals' experience diminished social motivation due to reduced social reward, social orienting, and social maintaining. Low social motivation has been linked to increased vulnerability to internalizing difficulties within this population. This systematic review and meta-analysis examined the relationship between social motivation and internalizing symptoms across the lifespan in autistic individuals. Relevant research papers until February 2025 were identified by searching EMBASE, PsycINFO, PubMed, and Web of Science databases (PROSPERO protocol: CRD42024547863). The systematic review included 14 studies (n?=?4590). A total of three meta-analyses were run using Pearson's correlation coefficients between social motivation and (1) anxiety, (2) depression, and (3) social anxiety, and the moderating effect of age, sex, and study quality were assessed using meta-regressions. Sensitivity analyses were run to assess whether one study was influencing the results of the meta-analysis. Greater difficulties with social motivation are associated with increased anxiety, depression, and social anxiety, with a moderate pooled effect size across all domains. Sensitivity analyses did not significantly alter any of the results. Age, sex, and quality of study were nonsignificant moderators. Reduced social motivation may be associated with an increased vulnerability to internalizing difficulties in autistic individuals. The stability across age, sex, and study quality highlights social motivation as a potential transdiagnostic target for intervention in autistic individuals. En ligne : https://doi.org/10.1002/aur.70185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Examining the Relationship Between Social Motivation and Internalizing Symptoms in Autistic People: A Systematic Review and Meta-Analysis [texte imprimé] / Katie LINDSAY-WEBB, Auteur ; Poppy CLAYTON, Auteur ; Emily SIMONOFF, Auteur ; Matthew J. HOLLOCKS, Auteur . - e70185. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70185 Index. décimale : PER Périodiques Résumé : ABSTRACT The social motivation theory hypothesizes that autistic individuals' experience diminished social motivation due to reduced social reward, social orienting, and social maintaining. Low social motivation has been linked to increased vulnerability to internalizing difficulties within this population. This systematic review and meta-analysis examined the relationship between social motivation and internalizing symptoms across the lifespan in autistic individuals. Relevant research papers until February 2025 were identified by searching EMBASE, PsycINFO, PubMed, and Web of Science databases (PROSPERO protocol: CRD42024547863). The systematic review included 14 studies (n?=?4590). A total of three meta-analyses were run using Pearson's correlation coefficients between social motivation and (1) anxiety, (2) depression, and (3) social anxiety, and the moderating effect of age, sex, and study quality were assessed using meta-regressions. Sensitivity analyses were run to assess whether one study was influencing the results of the meta-analysis. Greater difficulties with social motivation are associated with increased anxiety, depression, and social anxiety, with a moderate pooled effect size across all domains. Sensitivity analyses did not significantly alter any of the results. Age, sex, and quality of study were nonsignificant moderators. Reduced social motivation may be associated with an increased vulnerability to internalizing difficulties in autistic individuals. The stability across age, sex, and study quality highlights social motivation as a potential transdiagnostic target for intervention in autistic individuals. En ligne : https://doi.org/10.1002/aur.70185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Gene–Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility / Eduardo QUIÑONES-MEDINA in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70186 Titre : Gene–Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility Type de document : texte imprimé Auteurs : Eduardo QUIÑONES-MEDINA, Auteur ; Felipe GALLEGUILLOS, Auteur ; Valentina PARRA, Auteur ; Gloria ARRIAGADA, Auteur ; Fernando J. BUSTOS, Auteur Article en page(s) : e70186 Langues : Anglais (eng) Mots-clés : ASD  Bisphenol-A  BPA  environment Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition shaped by both genetic and environmental factors. While genetic studies have identified monogenic and polygenic contributions to ASD, growing evidence suggests that environmental exposures can modulate genetic susceptibility. Among these, bisphenol A (BPA), a widely studied endocrine-disrupting chemical, has drawn attention due to its ability to cross the blood?brain barrier and placenta. BPA can influence neurodevelopment through epigenetic modifications, mitochondrial dysfunction, and oxidative stress. Elevated BPA levels have been detected in serum and urine of individuals with ASD, correlating with altered gene expression in brain regions critical for cognition and behavior. Experimental models indicate that BPA exposure disrupts neuronal viability, synaptic connectivity, and neurotransmitter regulation, potentially exacerbating ASD-like phenotypes in genetically predisposed individuals. This review explores the interaction between genetic risk factors and environmental toxins, particularly BPA, in ASD pathogenesis. By integrating findings from epidemiological studies, molecular analyses, and animal models, we highlight the need for further research into gene?environment interactions to refine ASD risk assessment and therapeutic strategies. En ligne : https://doi.org/10.1002/aur.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Gene–Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility [texte imprimé] / Eduardo QUIÑONES-MEDINA, Auteur ; Felipe GALLEGUILLOS, Auteur ; Valentina PARRA, Auteur ; Gloria ARRIAGADA, Auteur ; Fernando J. BUSTOS, Auteur . - e70186. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70186 Mots-clés : ASD  Bisphenol-A  BPA  environment Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition shaped by both genetic and environmental factors. While genetic studies have identified monogenic and polygenic contributions to ASD, growing evidence suggests that environmental exposures can modulate genetic susceptibility. Among these, bisphenol A (BPA), a widely studied endocrine-disrupting chemical, has drawn attention due to its ability to cross the blood?brain barrier and placenta. BPA can influence neurodevelopment through epigenetic modifications, mitochondrial dysfunction, and oxidative stress. Elevated BPA levels have been detected in serum and urine of individuals with ASD, correlating with altered gene expression in brain regions critical for cognition and behavior. Experimental models indicate that BPA exposure disrupts neuronal viability, synaptic connectivity, and neurotransmitter regulation, potentially exacerbating ASD-like phenotypes in genetically predisposed individuals. This review explores the interaction between genetic risk factors and environmental toxins, particularly BPA, in ASD pathogenesis. By integrating findings from epidemiological studies, molecular analyses, and animal models, we highlight the need for further research into gene?environment interactions to refine ASD risk assessment and therapeutic strategies. En ligne : https://doi.org/10.1002/aur.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Cognitive Abilities and Irritability Are the Main Factors Influencing Initial Placement of Autistic Preschoolers in Special or Mainstream Education in Israel / Moran BACHRACH in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70188 Titre : Cognitive Abilities and Irritability Are the Main Factors Influencing Initial Placement of Autistic Preschoolers in Special or Mainstream Education in Israel Type de document : texte imprimé Auteurs : Moran BACHRACH, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Analya MICHAELOVSKY, Auteur ; Dikla ZAGDON, Auteur ; Yair SADAKA, Auteur ; Omer Bar YOSEF, Auteur ; Adi ARAN, Auteur ; Michal BEGIN, Auteur ; Ditza ZACHOR, Auteur ; Einat AVNI, Auteur ; Judah KOLLER, Auteur ; Idan MENASHE, Auteur ; Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur Article en page(s) : e70188 Langues : Anglais (eng) Mots-clés : autism  cognitive abilities  irritability  mainstream education  preschool placement  special education Index. décimale : PER Périodiques Résumé : ABSTRACT Following diagnosis, autistic children are often placed in preschool settings that vary along a continuum from exclusive special education to inclusive mainstream education. These settings differ in their staff composition and expertise, ability to implement structured autism interventions, ability to integrate autistic and typically developing children, and costs. Here, we examined whether there were significant differences in the behavioral abilities and developmental difficulties of children placed in special versus mainstream public education in Israel, where there is a systematic dichotomy between the two educational settings. We analyzed data from 165 autistic children, 120 in special and 45 in mainstream education, who completed comprehensive behavioral assessments at a mean age of 37.8?months, as they entered their first preschool setting. Children placed in special education exhibited significantly poorer cognitive abilities and higher irritability and hyperactivity than children in mainstream education while there were no significant differences in autism severity or adaptive behaviors across groups. Moreover, cognitive and irritability scores were sufficient for classifying children across the two settings with an average accuracy of 76.4% when using a pruned decision tree algorithm and a 5-fold cross-validation procedure. These findings extend previous research by demonstrating that cognitive abilities and irritability are the strongest predictors of preschool educational placement. Further longitudinal research is needed to determine whether these placement decisions benefit the children as they develop. En ligne : https://doi.org/10.1002/aur.70188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Cognitive Abilities and Irritability Are the Main Factors Influencing Initial Placement of Autistic Preschoolers in Special or Mainstream Education in Israel [texte imprimé] / Moran BACHRACH, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Analya MICHAELOVSKY, Auteur ; Dikla ZAGDON, Auteur ; Yair SADAKA, Auteur ; Omer Bar YOSEF, Auteur ; Adi ARAN, Auteur ; Michal BEGIN, Auteur ; Ditza ZACHOR, Auteur ; Einat AVNI, Auteur ; Judah KOLLER, Auteur ; Idan MENASHE, Auteur ; Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur . - e70188. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70188 Mots-clés : autism  cognitive abilities  irritability  mainstream education  preschool placement  special education Index. décimale : PER Périodiques Résumé : ABSTRACT Following diagnosis, autistic children are often placed in preschool settings that vary along a continuum from exclusive special education to inclusive mainstream education. These settings differ in their staff composition and expertise, ability to implement structured autism interventions, ability to integrate autistic and typically developing children, and costs. Here, we examined whether there were significant differences in the behavioral abilities and developmental difficulties of children placed in special versus mainstream public education in Israel, where there is a systematic dichotomy between the two educational settings. We analyzed data from 165 autistic children, 120 in special and 45 in mainstream education, who completed comprehensive behavioral assessments at a mean age of 37.8?months, as they entered their first preschool setting. Children placed in special education exhibited significantly poorer cognitive abilities and higher irritability and hyperactivity than children in mainstream education while there were no significant differences in autism severity or adaptive behaviors across groups. Moreover, cognitive and irritability scores were sufficient for classifying children across the two settings with an average accuracy of 76.4% when using a pruned decision tree algorithm and a 5-fold cross-validation procedure. These findings extend previous research by demonstrating that cognitive abilities and irritability are the strongest predictors of preschool educational placement. Further longitudinal research is needed to determine whether these placement decisions benefit the children as they develop. En ligne : https://doi.org/10.1002/aur.70188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Parental Stress and Caregiver Role Modulate Child–Caregiver Prosodic Synchrony in Autism: A Computational Analysis / Maria Grazia LOGRIECO in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70189 Titre : Parental Stress and Caregiver Role Modulate Child–Caregiver Prosodic Synchrony in Autism: A Computational Analysis Type de document : texte imprimé Auteurs : Maria Grazia LOGRIECO, Auteur ; Giulio BERTAMINI, Auteur ; Laura CASULA, Auteur ; Mohamed CHETOUANI, Auteur ; Silvia GUERRERA, Auteur ; Mirco FASOLO, Auteur ; Paola VENUTI, Auteur ; Maria Luisa SCATTONI, Auteur ; Francesca FULCERI, Auteur ; Stefano VICARI, Auteur ; David COHEN, Auteur ; Giovanni VALERI, Auteur Article en page(s) : e70189 Langues : Anglais (eng) Mots-clés : artificial intelligence  autism  caregiver role  interaction  parents  prosodic synchrony  stress Index. décimale : PER Périodiques Résumé : ABSTRACT Parental stress influences parent?child interactions in typical development and is a prognostic factor of autism outcome. However, we still do not know to what extent parental stress affects parent?child interactions and whether caregiver role matters. This study explored the relationship between parental stress and prosodic synchrony in parent?child vocal interactions, drawing on complex dynamic systems and affective computing frameworks. We assessed 62 dyads (31 autistic preschoolers, interacting separately with their mother and father) during structured play interactions at two time points (12?months apart) along with perceived parental stress. We used a Deep Learning model to segment child-caregiver acoustic interactions with high accuracy automatically. Downstream, prosodic synchrony was modeled through cross-recurrence quantification analysis. Linear mixed-effects models were used to assess the impact of parental stress, caregiver role, and time on synchrony metrics. Models showed significant associations between parental stress and synchrony metrics for spectral and formant amplitude features. Higher stress levels were linked to less stable, predictable, and structured interactions. These effects were more pronounced in father?child dyads compared to mother?child dyads. Permutation analyses confirmed that these associations were specific to moment-to-moment coordination rather than general acoustic similarity. In autistic children, parental stress levels are linked with the temporal dynamics of parent?child prosodic synchrony, specifically affective speech and moment-to-moment coordination. It appears to be more pronounced in fathers. The results underscore the importance of fostering parental well-being and tailoring interventions to account for differences between maternal and paternal interaction patterns in autism. En ligne : https://doi.org/10.1002/aur.70189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Parental Stress and Caregiver Role Modulate Child–Caregiver Prosodic Synchrony in Autism: A Computational Analysis [texte imprimé] / Maria Grazia LOGRIECO, Auteur ; Giulio BERTAMINI, Auteur ; Laura CASULA, Auteur ; Mohamed CHETOUANI, Auteur ; Silvia GUERRERA, Auteur ; Mirco FASOLO, Auteur ; Paola VENUTI, Auteur ; Maria Luisa SCATTONI, Auteur ; Francesca FULCERI, Auteur ; Stefano VICARI, Auteur ; David COHEN, Auteur ; Giovanni VALERI, Auteur . - e70189. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70189 Mots-clés : artificial intelligence  autism  caregiver role  interaction  parents  prosodic synchrony  stress Index. décimale : PER Périodiques Résumé : ABSTRACT Parental stress influences parent?child interactions in typical development and is a prognostic factor of autism outcome. However, we still do not know to what extent parental stress affects parent?child interactions and whether caregiver role matters. This study explored the relationship between parental stress and prosodic synchrony in parent?child vocal interactions, drawing on complex dynamic systems and affective computing frameworks. We assessed 62 dyads (31 autistic preschoolers, interacting separately with their mother and father) during structured play interactions at two time points (12?months apart) along with perceived parental stress. We used a Deep Learning model to segment child-caregiver acoustic interactions with high accuracy automatically. Downstream, prosodic synchrony was modeled through cross-recurrence quantification analysis. Linear mixed-effects models were used to assess the impact of parental stress, caregiver role, and time on synchrony metrics. Models showed significant associations between parental stress and synchrony metrics for spectral and formant amplitude features. Higher stress levels were linked to less stable, predictable, and structured interactions. These effects were more pronounced in father?child dyads compared to mother?child dyads. Permutation analyses confirmed that these associations were specific to moment-to-moment coordination rather than general acoustic similarity. In autistic children, parental stress levels are linked with the temporal dynamics of parent?child prosodic synchrony, specifically affective speech and moment-to-moment coordination. It appears to be more pronounced in fathers. The results underscore the importance of fostering parental well-being and tailoring interventions to account for differences between maternal and paternal interaction patterns in autism. En ligne : https://doi.org/10.1002/aur.70189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Optimizing Measurement of Communication in Autistic Children and Their Caregivers: Dependability of the Caregiver-Child Interaction / Lauren H. HAMPTON in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70191 Titre : Optimizing Measurement of Communication in Autistic Children and Their Caregivers: Dependability of the Caregiver-Child Interaction Type de document : texte imprimé Auteurs : Lauren H. HAMPTON, Auteur ; Anna-Mari FALL, Auteur ; Jerrica BUTLER, Auteur ; Greg ROBERTS, Auteur ; Younghwa NOH, Auteur Article en page(s) : e70191 Langues : Anglais (eng) Mots-clés : autism  generalizability theory  measurement  parent-mediated intervention  social communication Index. décimale : PER Périodiques Résumé : ABSTRACT Despite widespread use of caregiver-child interactions (CCX) to evaluate outcomes in autism interventions, little research has examined the dependability of this measure. This study applied generalizability theory to determine optimal conditions for dependable assessment of child communication and caregiver implementation of communication intervention strategies. Twenty caregiver-child dyads participated in structured interactions across six daily activities on two occasions. Young autistic child communication was measured via tele-health using the Individual Growth and Development Indicators (IGDI) and caregiver implementation using the Naturalistic Developmental Behavioral Intervention Fidelity (NDBI-Fi) scale. Both measures demonstrated strong generalizability when multiple observations were conducted, but significantly lower dependability with single observations. For child communication, three to five activities across two occasions provided optimal dependability (Φ?=?0.69?0.82). For caregiver implementation, either four activities on one occasion (Φ?=?0.80) or two activities across two occasions (Φ?=?0.81) yielded dependable estimates. The greatest sources of error variance were person-by-occasion (54%?59%) and person-by-activity interactions (20%?28%), with all six activities contributing similarly to measurement error. Results indicate that researchers should prioritize collecting multiple CCX observations across different activities and occasions when sampling via telehealth. For optimal feasibility and generalizability, we recommend two observations of 3?4 play-based activities to balance measurement precision with participant burden and intervention relevance. En ligne : https://doi.org/10.1002/aur.70191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Optimizing Measurement of Communication in Autistic Children and Their Caregivers: Dependability of the Caregiver-Child Interaction [texte imprimé] / Lauren H. HAMPTON, Auteur ; Anna-Mari FALL, Auteur ; Jerrica BUTLER, Auteur ; Greg ROBERTS, Auteur ; Younghwa NOH, Auteur . - e70191. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70191 Mots-clés : autism  generalizability theory  measurement  parent-mediated intervention  social communication Index. décimale : PER Périodiques Résumé : ABSTRACT Despite widespread use of caregiver-child interactions (CCX) to evaluate outcomes in autism interventions, little research has examined the dependability of this measure. This study applied generalizability theory to determine optimal conditions for dependable assessment of child communication and caregiver implementation of communication intervention strategies. Twenty caregiver-child dyads participated in structured interactions across six daily activities on two occasions. Young autistic child communication was measured via tele-health using the Individual Growth and Development Indicators (IGDI) and caregiver implementation using the Naturalistic Developmental Behavioral Intervention Fidelity (NDBI-Fi) scale. Both measures demonstrated strong generalizability when multiple observations were conducted, but significantly lower dependability with single observations. For child communication, three to five activities across two occasions provided optimal dependability (Φ?=?0.69?0.82). For caregiver implementation, either four activities on one occasion (Φ?=?0.80) or two activities across two occasions (Φ?=?0.81) yielded dependable estimates. The greatest sources of error variance were person-by-occasion (54%?59%) and person-by-activity interactions (20%?28%), with all six activities contributing similarly to measurement error. Results indicate that researchers should prioritize collecting multiple CCX observations across different activities and occasions when sampling via telehealth. For optimal feasibility and generalizability, we recommend two observations of 3?4 play-based activities to balance measurement precision with participant burden and intervention relevance. En ligne : https://doi.org/10.1002/aur.70191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

ToM2 : Parental Perception of Theory of Mind Abilities in Autistic Children / Liraz Sasportas JOSEPH in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70192 Titre : ToM2 : Parental Perception of Theory of Mind Abilities in Autistic Children Type de document : texte imprimé Auteurs : Liraz Sasportas JOSEPH, Auteur ; Michal PEREZ, Auteur ; Anat PERRY, Auteur ; Judah KOLLER, Auteur Article en page(s) : e70192 Langues : Anglais (eng) Mots-clés : autism  mentalization  parent–child interaction  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Understanding how parents perceive their children's abilities is crucial for family dynamics and intervention strategies, particularly in autism, where accurate parental assessment of social-cognitive capabilities can influence support approaches and developmental outcomes. This study introduces ToM2, a novel measure examining parents' ability to predict their autistic child's Theory of Mind (ToM) performance, representing a form of mentalization that requires parents to evaluate how their child understands others' mental states. We recruited 54 parent?child dyads (43 included in final analyses) from families with children diagnosed with autism (ages 42?70?months). Children completed a six-task ToM scale, while parents predicted their child's responses to each task. ToM2 accuracy was calculated based on the match between parental predictions and child performance. We examined the relationships between ToM2 accuracy and family accommodation for restricted and repetitive behaviors, autism symptom severity, and parental broader autism phenotype characteristics using logistic mixed-effects modeling. Results revealed that parents with higher levels of family accommodation demonstrated significantly lower ToM2 accuracy (p?=?0.030), suggesting that higher accommodation is associated with reduced accuracy in perceiving social-cognitive abilities, consistent with bidirectional parent?child interaction patterns. Greater autism symptom severity showed a trend toward reduced ToM2 accuracy (p?=?0.051), possibly suggesting that more pronounced autism characteristics may present greater challenges for parental mentalization. Parental broader autism phenotype was not associated with ToM2 accuracy. These findings suggest that ToM2 represents a useful framework for parental mentalization in autism and may inform family-centered interventions targeting both accommodation behaviors and parental perception accuracy. En ligne : https://doi.org/10.1002/aur.70192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] ToM2 : Parental Perception of Theory of Mind Abilities in Autistic Children [texte imprimé] / Liraz Sasportas JOSEPH, Auteur ; Michal PEREZ, Auteur ; Anat PERRY, Auteur ; Judah KOLLER, Auteur . - e70192. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70192 Mots-clés : autism  mentalization  parent–child interaction  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Understanding how parents perceive their children's abilities is crucial for family dynamics and intervention strategies, particularly in autism, where accurate parental assessment of social-cognitive capabilities can influence support approaches and developmental outcomes. This study introduces ToM2, a novel measure examining parents' ability to predict their autistic child's Theory of Mind (ToM) performance, representing a form of mentalization that requires parents to evaluate how their child understands others' mental states. We recruited 54 parent?child dyads (43 included in final analyses) from families with children diagnosed with autism (ages 42?70?months). Children completed a six-task ToM scale, while parents predicted their child's responses to each task. ToM2 accuracy was calculated based on the match between parental predictions and child performance. We examined the relationships between ToM2 accuracy and family accommodation for restricted and repetitive behaviors, autism symptom severity, and parental broader autism phenotype characteristics using logistic mixed-effects modeling. Results revealed that parents with higher levels of family accommodation demonstrated significantly lower ToM2 accuracy (p?=?0.030), suggesting that higher accommodation is associated with reduced accuracy in perceiving social-cognitive abilities, consistent with bidirectional parent?child interaction patterns. Greater autism symptom severity showed a trend toward reduced ToM2 accuracy (p?=?0.051), possibly suggesting that more pronounced autism characteristics may present greater challenges for parental mentalization. Parental broader autism phenotype was not associated with ToM2 accuracy. These findings suggest that ToM2 represents a useful framework for parental mentalization in autism and may inform family-centered interventions targeting both accommodation behaviors and parental perception accuracy. En ligne : https://doi.org/10.1002/aur.70192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Urban–Rural Differences and Sex-Specific Cognitive Effects on Autism Symptom Trajectories: A Longitudinal Study of Autistic Children in Taiwan / Yun-Ju CHEN in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70193 Titre : Urban–Rural Differences and Sex-Specific Cognitive Effects on Autism Symptom Trajectories: A Longitudinal Study of Autistic Children in Taiwan Type de document : texte imprimé Auteurs : Yun-Ju CHEN, Auteur ; Hsiang-Yuan LIN, Auteur ; Ching-Lin CHU, Auteur ; Chin-Chin WU, Auteur ; Tzu-Ling LIN, Auteur ; Hsing-Chang NI, Auteur ; Jiun-Horng LIU, Auteur ; Yuh-Ming HOU, Auteur ; Chung-Hsin CHIANG, Auteur Article en page(s) : e70193 Langues : Anglais (eng) Mots-clés : autism  IQ  longitudinal  multilevel modeling  severity change  sex differences Index. décimale : PER Périodiques Résumé : ABSTRACT Few longitudinal studies have mapped autism symptom trajectories outside Western contexts. This study aimed to characterize trajectories of autism symptoms, assessed using the Autism Diagnostic Observation Schedule (ADOS), and associated child and family factors among autistic children from two regions in Taiwan that differ by urbanicity. Another aim was to examine the time-varying effects of children's cognitive abilities on autism symptoms, which remain understudied due to prior reliance on baseline proxies. Children with a confirmed autism diagnosis (n?=?180, 87.8% male) were followed across three waves of data collection from ages 2 to 11?years. Linear multilevel growth models with random intercepts and slopes were used to estimate symptom trajectories at the total and domain levels of the ADOS. On average, total and social-affect symptoms increased significantly with age, while restricted and repetitive behaviors (RRBs) remained stable. Children from urban areas showed higher baseline RRBs and smaller increases in social-affect symptoms compared to those from rural areas. Additionally, children diagnosed under DSM-5 criteria showed lower baseline symptoms but greater increases in total/social-affect symptoms over time than their DSM-IV counterparts. A sex interaction effect was observed in the time-varying associations between IQ (particularly verbal IQ) and total/social-affect symptoms, with girls showing stronger negative IQ-symptom associations. These findings highlight the developmental complexity underlying the manifestation of autism symptoms, particularly at the intersection of sex and cognition. The distinct patterns by urbanicity also underscore the need to mitigate urban?rural disparities in service access to better support autistic children's long-term outcomes. En ligne : https://doi.org/10.1002/aur.70193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Urban–Rural Differences and Sex-Specific Cognitive Effects on Autism Symptom Trajectories: A Longitudinal Study of Autistic Children in Taiwan [texte imprimé] / Yun-Ju CHEN, Auteur ; Hsiang-Yuan LIN, Auteur ; Ching-Lin CHU, Auteur ; Chin-Chin WU, Auteur ; Tzu-Ling LIN, Auteur ; Hsing-Chang NI, Auteur ; Jiun-Horng LIU, Auteur ; Yuh-Ming HOU, Auteur ; Chung-Hsin CHIANG, Auteur . - e70193. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70193 Mots-clés : autism  IQ  longitudinal  multilevel modeling  severity change  sex differences Index. décimale : PER Périodiques Résumé : ABSTRACT Few longitudinal studies have mapped autism symptom trajectories outside Western contexts. This study aimed to characterize trajectories of autism symptoms, assessed using the Autism Diagnostic Observation Schedule (ADOS), and associated child and family factors among autistic children from two regions in Taiwan that differ by urbanicity. Another aim was to examine the time-varying effects of children's cognitive abilities on autism symptoms, which remain understudied due to prior reliance on baseline proxies. Children with a confirmed autism diagnosis (n?=?180, 87.8% male) were followed across three waves of data collection from ages 2 to 11?years. Linear multilevel growth models with random intercepts and slopes were used to estimate symptom trajectories at the total and domain levels of the ADOS. On average, total and social-affect symptoms increased significantly with age, while restricted and repetitive behaviors (RRBs) remained stable. Children from urban areas showed higher baseline RRBs and smaller increases in social-affect symptoms compared to those from rural areas. Additionally, children diagnosed under DSM-5 criteria showed lower baseline symptoms but greater increases in total/social-affect symptoms over time than their DSM-IV counterparts. A sex interaction effect was observed in the time-varying associations between IQ (particularly verbal IQ) and total/social-affect symptoms, with girls showing stronger negative IQ-symptom associations. These findings highlight the developmental complexity underlying the manifestation of autism symptoms, particularly at the intersection of sex and cognition. The distinct patterns by urbanicity also underscore the need to mitigate urban?rural disparities in service access to better support autistic children's long-term outcomes. En ligne : https://doi.org/10.1002/aur.70193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome / Mélodie PROTEAU-LEMIEUX in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70194 Titre : Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome Type de document : texte imprimé Auteurs : Mélodie PROTEAU-LEMIEUX, Auteur ; Inga S. KNOTH, Auteur ; Saeideh DAVOUDI, Auteur ; Rae BUCKSER, Auteur ; Charles-Olivier MARTIN, Auteur ; Anne-Marie BÉLANGER, Auteur ; Valérie K. FONTAINE, Auteur ; Hazel Maridith Barlahan BIAG, Auteur ; Leonard ABBEDUTO, Auteur ; Sébastien JACQUEMONT, Auteur ; David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Andrea SCHNEIDER, Auteur ; Francois V. BOLDUC, Auteur ; Sarah LIPPE, Auteur Article en page(s) : e70194 Langues : Anglais (eng) Mots-clés : behavior  cognition  EEG  fragile X syndrome  PSD  resting state  signal complexity Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X Syndrome (FXS), an X-linked genetic condition, is associated with a wide range of phenotypic manifestations, namely intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and atypical behaviors. Individuals with FXS present robust electrophysiological (EEG) alterations, notably on signal complexity and power spectral density (PSD) resting state measures. To which extent they are associated to specific behavioral phenotypes in the FXS population remains to be comprehensively addressed. This study aimed to investigate the relations between resting state EEG markers and the most frequently observed symptoms in FXS. EEG and behavioral data from 41 individuals with FXS aged between 7 and 34?years old were collected, and correlational approaches were used to analyze the associations between EEG markers and symptomatology. We observed positive associations between complexity in higher scales and non-verbal intelligence quotient (NVIQ). Reduced alpha power, a robust biomarker in FXS, was associated with more social avoidance, a hallmark in FXS. Decreased high gamma power was linked to hyperactive symptoms. Our results suggest powerful relations between known biomarkers and core symptoms in FXS, highlighting that EEG biomarkers correspond to symptom severity which further supports their potential as objective, translational treatment outcome measures. En ligne : https://doi.org/10.1002/aur.70194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome [texte imprimé] / Mélodie PROTEAU-LEMIEUX, Auteur ; Inga S. KNOTH, Auteur ; Saeideh DAVOUDI, Auteur ; Rae BUCKSER, Auteur ; Charles-Olivier MARTIN, Auteur ; Anne-Marie BÉLANGER, Auteur ; Valérie K. FONTAINE, Auteur ; Hazel Maridith Barlahan BIAG, Auteur ; Leonard ABBEDUTO, Auteur ; Sébastien JACQUEMONT, Auteur ; David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Andrea SCHNEIDER, Auteur ; Francois V. BOLDUC, Auteur ; Sarah LIPPE, Auteur . - e70194. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70194 Mots-clés : behavior  cognition  EEG  fragile X syndrome  PSD  resting state  signal complexity Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X Syndrome (FXS), an X-linked genetic condition, is associated with a wide range of phenotypic manifestations, namely intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and atypical behaviors. Individuals with FXS present robust electrophysiological (EEG) alterations, notably on signal complexity and power spectral density (PSD) resting state measures. To which extent they are associated to specific behavioral phenotypes in the FXS population remains to be comprehensively addressed. This study aimed to investigate the relations between resting state EEG markers and the most frequently observed symptoms in FXS. EEG and behavioral data from 41 individuals with FXS aged between 7 and 34?years old were collected, and correlational approaches were used to analyze the associations between EEG markers and symptomatology. We observed positive associations between complexity in higher scales and non-verbal intelligence quotient (NVIQ). Reduced alpha power, a robust biomarker in FXS, was associated with more social avoidance, a hallmark in FXS. Decreased high gamma power was linked to hyperactive symptoms. Our results suggest powerful relations between known biomarkers and core symptoms in FXS, highlighting that EEG biomarkers correspond to symptom severity which further supports their potential as objective, translational treatment outcome measures. En ligne : https://doi.org/10.1002/aur.70194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583