Association of cognitive and adaptive skills with internalizing and externalizing problems in autistic children and adolescents / Javiera DONOSO in Autism Research, 17-3 (March 2024)  

Public ISBD [article]  inAutism Research > 17-3 (March 2024) . - p.596-609 Titre : Association of cognitive and adaptive skills with internalizing and externalizing problems in autistic children and adolescents Type de document : texte imprimé Auteurs : Javiera DONOSO, Auteur ; Fiona RATTRAY, Auteur ; Annelies A. DE BILDT, Auteur ; Julian TILLMANN, Auteur ; Penny WILLIAMS, Auteur ; Michael ABSOUD, Auteur ; Vasiliki TOTSIKA, Auteur Article en page(s) : p.596-609 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The presence of an intellectual disability (ID) alongside autism is considered to increase the risk for mental health and behavior problems in children and adolescents. Existing evidence is restricted by looking at ID as a categorical classification. The study aimed to examine the association of cognitive and adaptive behavior skills with internalizing and externalizing problems in a large sample of autistic children and adolescents, across a wide range of cognitive skills. Participants were 2759 children and adolescents aged between 4 and 18 years recruited as part of the Simons Simplex Collection (SSC), of whom 709 (approximately 25%) had ID. Multiple regression models examined associations of internalizing and externalizing problems with cognitive and adaptive skills (communication, daily living, and socialization skills). Cognitive skills were not associated with externalizing problems but were associated with more internalizing problems in autistic children without ID (Cog ?: 0.126). All adaptive skill domains were inversely associated with externalizing (Communication ?: 0.145; Daily-Living ?: 0.132; Socialization ?: 0.289) and internalizing problems (Communication ?: 0.074; Daily-Living ?: 0.064; Socialization ?: 0.213) in those without ID. Daily living (?: 0.158) and socialization skills (?: 0.104) were inversely correlated with externalizing problems in autistic children with ID, while only socialization problems (?: 0.099) were associated with internalizing problems in this group. Socialization skills were systematically associated with internalizing and externalizing problems across all levels of cognitive functioning. Supporting social skills development may benefit all aspects of child mental health, while recognizing that children with higher cognitive skills are more vulnerable to internalizing problems might assist with earlier identification of these problems. En ligne : https://doi.org/10.1002/aur.3056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525 [article] Association of cognitive and adaptive skills with internalizing and externalizing problems in autistic children and adolescents [texte imprimé] / Javiera DONOSO, Auteur ; Fiona RATTRAY, Auteur ; Annelies A. DE BILDT, Auteur ; Julian TILLMANN, Auteur ; Penny WILLIAMS, Auteur ; Michael ABSOUD, Auteur ; Vasiliki TOTSIKA, Auteur . - p.596-609. Langues : Anglais (eng) in Autism Research > 17-3 (March 2024) . - p.596-609 Index. décimale : PER Périodiques Résumé : Abstract The presence of an intellectual disability (ID) alongside autism is considered to increase the risk for mental health and behavior problems in children and adolescents. Existing evidence is restricted by looking at ID as a categorical classification. The study aimed to examine the association of cognitive and adaptive behavior skills with internalizing and externalizing problems in a large sample of autistic children and adolescents, across a wide range of cognitive skills. Participants were 2759 children and adolescents aged between 4 and 18 years recruited as part of the Simons Simplex Collection (SSC), of whom 709 (approximately 25%) had ID. Multiple regression models examined associations of internalizing and externalizing problems with cognitive and adaptive skills (communication, daily living, and socialization skills). Cognitive skills were not associated with externalizing problems but were associated with more internalizing problems in autistic children without ID (Cog ?: 0.126). All adaptive skill domains were inversely associated with externalizing (Communication ?: 0.145; Daily-Living ?: 0.132; Socialization ?: 0.289) and internalizing problems (Communication ?: 0.074; Daily-Living ?: 0.064; Socialization ?: 0.213) in those without ID. Daily living (?: 0.158) and socialization skills (?: 0.104) were inversely correlated with externalizing problems in autistic children with ID, while only socialization problems (?: 0.099) were associated with internalizing problems in this group. Socialization skills were systematically associated with internalizing and externalizing problems across all levels of cognitive functioning. Supporting social skills development may benefit all aspects of child mental health, while recognizing that children with higher cognitive skills are more vulnerable to internalizing problems might assist with earlier identification of these problems. En ligne : https://doi.org/10.1002/aur.3056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525

Contrasting the Effects of Task Difficulty and Perceptual Load on Auditory Detection Sensitivity in Individuals with Autism / Julian TILLMANN in Journal of Autism and Developmental Disorders, 49-2 (February 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.762-772 Titre : Contrasting the Effects of Task Difficulty and Perceptual Load on Auditory Detection Sensitivity in Individuals with Autism Type de document : texte imprimé Auteurs : Julian TILLMANN, Auteur ; J. SWETTENHAM, Auteur Article en page(s) : p.762-772 Langues : Anglais (eng) Mots-clés : Auditory detection sensitivity  Autism spectrum disorder  Perceptual load  Selective attention  Task difficulty Index. décimale : PER Périodiques Résumé : To test a central assumption of the increased perceptual capacity account in individuals with Autism Spectrum Disorder (ASD), the effects of perceptual load and target-stimulus degradation on auditory detection sensitivity were contrasted. Fourteen adolescents with ASD and 16 neurotypical controls performed a visual letter search task under three conditions: low perceptual load, high perceptual load and low perceptual load with a degraded target while simultaneously detecting an auditory tone in noise. For both participants with ASD and neurotypical controls, increasing perceptual load and target degradation increased task difficulty as indexed by reaction times and accuracy. However, only increasing perceptual load reduced subsequent auditory detection sensitivity. The study confirms that perceptual load, and not task difficulty, modulates selective attention in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3766-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 [article] Contrasting the Effects of Task Difficulty and Perceptual Load on Auditory Detection Sensitivity in Individuals with Autism [texte imprimé] / Julian TILLMANN, Auteur ; J. SWETTENHAM, Auteur . - p.762-772. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.762-772 Mots-clés : Auditory detection sensitivity  Autism spectrum disorder  Perceptual load  Selective attention  Task difficulty Index. décimale : PER Périodiques Résumé : To test a central assumption of the increased perceptual capacity account in individuals with Autism Spectrum Disorder (ASD), the effects of perceptual load and target-stimulus degradation on auditory detection sensitivity were contrasted. Fourteen adolescents with ASD and 16 neurotypical controls performed a visual letter search task under three conditions: low perceptual load, high perceptual load and low perceptual load with a degraded target while simultaneously detecting an auditory tone in noise. For both participants with ASD and neurotypical controls, increasing perceptual load and target degradation increased task difficulty as indexed by reaction times and accuracy. However, only increasing perceptual load reduced subsequent auditory detection sensitivity. The study confirms that perceptual load, and not task difficulty, modulates selective attention in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3766-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach / Julian TILLMANN in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 67 p. Titre : Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach Type de document : texte imprimé Auteurs : Julian TILLMANN, Auteur ; Mirko ULJAREVIĆ, Auteur ; Daisy CRAWLEY, Auteur ; Guillaume DUMAS, Auteur ; Eva LOTH, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tony CHARMAN, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Anxiety  Autism spectrum disorder  Heterogeneity  Phenotype  Sensory features  Social-communication symptoms  of/and/or speaker for Takeda/Shire, Roche, Medice, Servier and Angelini. He is not  an employee of any of these companies, and not a stock shareholder of any of these  companies. He has no other financial or material support, including expert  testimony, patents and royalties. Julian Tillmann is a consultant to F. Hoffmann-La  Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intrinsically in their severity along continuous factor scores. We also investigated sensory subgroups in relation to clinical variables: sex, age, IQ, social-communication symptoms, restricted and repetitive behaviours, adaptive functioning and symptoms of anxiety and attention-deficit/hyperactivity disorder. METHODS: Three hundred thirty-two children and adults with ASD between the ages of 6 and 30 years with IQs varying between 40 and 148 were included. First, three different confirmatory factor models were fit to the 38 items of the Short Sensory Profile (SSP). Then, latent class models (with two-to-six subgroups) were evaluated. The best performing factor model, the 7-factor structure, was subsequently used in two FMMs that varied in the number of subgroups: a two-subgroup, seven-factor model and a three-subgroup and seven-factor model. RESULTS: The 'three-subgroup/seven-factor' FMM was superior to all other models based on different fit criteria. Identified subgroups differed in sensory severity from severe, moderate to low. Accounting for the potential confounding effects of age and IQ, participants in these sensory subgroups had different levels of social-communicative symptoms, restricted and repetitive behaviours, adaptive functioning skills and symptoms of inattention and anxiety. LIMITATIONS: Results were derived using a single parent-report measure of sensory features, the SSP, which limits the generalisability of findings. CONCLUSION: Sensory features can be best described by three homogeneous sensory subgroups that differ in sensory severity gradients along seven continuous factor scores. Identified sensory subgroups were further differentiated by the severity of core and co-occurring symptoms, and level of adaptive functioning, providing novel evidence on the associated clinical correlates of sensory subgroups. These sensory subgroups provide a platform to further interrogate the neurobiological and genetic correlates of altered sensory processing in ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00367-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach [texte imprimé] / Julian TILLMANN, Auteur ; Mirko ULJAREVIĆ, Auteur ; Daisy CRAWLEY, Auteur ; Guillaume DUMAS, Auteur ; Eva LOTH, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tony CHARMAN, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 67 p. Mots-clés : Anxiety  Autism spectrum disorder  Heterogeneity  Phenotype  Sensory features  Social-communication symptoms  of/and/or speaker for Takeda/Shire, Roche, Medice, Servier and Angelini. He is not  an employee of any of these companies, and not a stock shareholder of any of these  companies. He has no other financial or material support, including expert  testimony, patents and royalties. Julian Tillmann is a consultant to F. Hoffmann-La  Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intrinsically in their severity along continuous factor scores. We also investigated sensory subgroups in relation to clinical variables: sex, age, IQ, social-communication symptoms, restricted and repetitive behaviours, adaptive functioning and symptoms of anxiety and attention-deficit/hyperactivity disorder. METHODS: Three hundred thirty-two children and adults with ASD between the ages of 6 and 30 years with IQs varying between 40 and 148 were included. First, three different confirmatory factor models were fit to the 38 items of the Short Sensory Profile (SSP). Then, latent class models (with two-to-six subgroups) were evaluated. The best performing factor model, the 7-factor structure, was subsequently used in two FMMs that varied in the number of subgroups: a two-subgroup, seven-factor model and a three-subgroup and seven-factor model. RESULTS: The 'three-subgroup/seven-factor' FMM was superior to all other models based on different fit criteria. Identified subgroups differed in sensory severity from severe, moderate to low. Accounting for the potential confounding effects of age and IQ, participants in these sensory subgroups had different levels of social-communicative symptoms, restricted and repetitive behaviours, adaptive functioning skills and symptoms of inattention and anxiety. LIMITATIONS: Results were derived using a single parent-report measure of sensory features, the SSP, which limits the generalisability of findings. CONCLUSION: Sensory features can be best described by three homogeneous sensory subgroups that differ in sensory severity gradients along seven continuous factor scores. Identified sensory subgroups were further differentiated by the severity of core and co-occurring symptoms, and level of adaptive functioning, providing novel evidence on the associated clinical correlates of sensory subgroups. These sensory subgroups provide a platform to further interrogate the neurobiological and genetic correlates of altered sensory processing in ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00367-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder / Julian TILLMANN in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2490-2505 Titre : Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Julian TILLMANN, Auteur ; K. ASHWOOD, Auteur ; Michael ABSOUD, Auteur ; Sven BÖLTE, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Jan K. BUITELAAR, Auteur ; Sara CALDERONI, Auteur ; R. CALVO, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Roberto CANITANO, Auteur ; Annelies A. DE BILDT, Auteur ; Marie GOMOT, Auteur ; Pieter J. HOEKSTRA, Auteur ; A. KAALE, Auteur ; H. MCCONACHIE, Auteur ; Declan G.M. MURPHY, Auteur ; Antonio NARZISI, Auteur ; Iris J. OOSTERLING, Auteur ; M. PEJOVIC-MILOVANCEVIC, Auteur ; Antonio M. PERSICO, Auteur ; O. PUIG, Auteur ; H. ROEYERS, Auteur ; Nanda N. ROMMELSE, Auteur ; Roberto SACCO, Auteur ; V. SCANDURRA, Auteur ; Andrew C. STANFIELD, Auteur ; E. ZANDER, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.2490-2505 Langues : Anglais (eng) Mots-clés : Age  Autism Spectrum Disorder  Phenotype  Sex  Symptom severity Index. décimale : PER Périodiques Résumé : Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology. En ligne : http://dx.doi.org/10.1007/s10803-018-3510-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder [texte imprimé] / Julian TILLMANN, Auteur ; K. ASHWOOD, Auteur ; Michael ABSOUD, Auteur ; Sven BÖLTE, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Jan K. BUITELAAR, Auteur ; Sara CALDERONI, Auteur ; R. CALVO, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Roberto CANITANO, Auteur ; Annelies A. DE BILDT, Auteur ; Marie GOMOT, Auteur ; Pieter J. HOEKSTRA, Auteur ; A. KAALE, Auteur ; H. MCCONACHIE, Auteur ; Declan G.M. MURPHY, Auteur ; Antonio NARZISI, Auteur ; Iris J. OOSTERLING, Auteur ; M. PEJOVIC-MILOVANCEVIC, Auteur ; Antonio M. PERSICO, Auteur ; O. PUIG, Auteur ; H. ROEYERS, Auteur ; Nanda N. ROMMELSE, Auteur ; Roberto SACCO, Auteur ; V. SCANDURRA, Auteur ; Andrew C. STANFIELD, Auteur ; E. ZANDER, Auteur ; Tony CHARMAN, Auteur . - p.2490-2505. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2490-2505 Mots-clés : Age  Autism Spectrum Disorder  Phenotype  Sex  Symptom severity Index. décimale : PER Périodiques Résumé : Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology. En ligne : http://dx.doi.org/10.1007/s10803-018-3510-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Facial expression recognition is linked to clinical and neurofunctional differences in autism / Hannah MEYER-LINDENBERG in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 43 p. Titre : Facial expression recognition is linked to clinical and neurofunctional differences in autism Type de document : texte imprimé Auteurs : Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Hannah HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary J. HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G.M. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur Article en page(s) : 43 p. Langues : Anglais (eng) Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Facial expression recognition is linked to clinical and neurofunctional differences in autism [texte imprimé] / Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Hannah HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary J. HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G.M. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur . - 43 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 43 p. Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Gray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project / Ting MEI in Molecular Autism, 11 (2020)  

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How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project / Bethany OAKLEY in Autism, 25-2 (February 2021)  

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Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project / Julian TILLMANN in Autism Research, 12-4 (April 2019)  

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Mapping the link between socio-economic factors, autistic traits and mental health across different settings / Teresa DEL BIANCO in Autism, 28-5 (May 2024)  

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Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers / Luke MASON in Molecular Autism, 12 (2021)  

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Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)  

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Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project / Carolin MOESSNANG in Molecular Autism, 11 (2020)  

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Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways / Julian TILLMANN ; Freddy CLIQUET ; Frédérique AMSELLEM ; Anna MARUANI ; Claire S. LEBLOND ; Anita BEGGIATO ; David GERMANAUD ; Anouck AMESTOY ; Myriam Ly LE-MOAL ; Daniel UMBRICHT ; Christopher H. CHATHAM ; Lorraine MURTAGH ; Manuel P. BOUVARD ; Marion LEBOYER ; Tony CHARMAN ; Thomas BOURGERON ; Richard DELORME ; Guillaume DUMAS ; EU-AIMS LEAP GROUP in Autism Research, 16-2 (February 2023)  

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The Effect of Visual Perceptual Load on Auditory Awareness in Autism Spectrum Disorder / Julian TILLMANN in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

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The Effect of Visual Perceptual Load on Auditory Awareness of Social vs. Non-social Stimuli in Individuals with Autism / Julian TILLMANN in Journal of Autism and Developmental Disorders, 51-4 (April 2021)  

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