Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder / Nancy E. ADLEMAN in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1149-1156 Titre : Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nancy E. ADLEMAN, Auteur ; Stephen J. FROMM, Auteur ; Varun RAZDAN, Auteur ; Reilly KAYSER, Auteur ; Daniel P. DICKSTEIN, Auteur ; Melissa A. BROTMAN, Auteur ; Daniel Samuel PINE, Auteur ; Ellen LEIBENLUFT, Auteur Année de publication : 2012 Article en page(s) : p.1149-1156 Langues : Anglais (eng) Mots-clés : Severe mood dysregulation  bipolar disorder  pediatric  longitudinal  neuroimaging  voxel-based morphometry  Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Background:  There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV. Methods:  An optimized, modulated voxel-based morphometry (VBM) analysis was conducted on structural MRI scans from 201 children (78 SMD, 55 BD, and 68 HV). In addition, 92 children (31 SMD, 34 BD, and 27 HV) were rescanned after 2 years (mean interval 1.99 ± 0.94 years), to compare time-related changes among the three groups. Results:  Cross-sectionally, the groups differed in gray matter (GM) volume in presupplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), insula, and globus pallidus. The cortical differences were driven mainly by increased GM volume in HV compared with BD and SMD. In globus pallidus, there was increased GM in BD compared with HV and SMD. Longitudinally, group-by-time interactions were evident in two clusters in the superior/inferior parietal lobule (R SPL/IPL) and in the precuneus. In both clusters, the interactions were driven by an abnormal increase in volume in BD. Conclusions:  Cross-sectionally, both BD and SMD are associated with structural abnormalities in frontal cortex, insula, and basal ganglia. Although some of these deficits overlap (insula and DLPFC), others differentiate SMD and BD (pre-SMA and globus pallidus). Abnormal developmental trajectories in lateral parietal cortex and precuneus are present in, and unique to, BD. Because of the high proportion of co-occurring ADHD in the SMD subjects, we could not separate effects of ADHD from those of SMD, and future research including a nonirritable ADHD group must address this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder [Texte imprimé et/ou numérique] / Nancy E. ADLEMAN, Auteur ; Stephen J. FROMM, Auteur ; Varun RAZDAN, Auteur ; Reilly KAYSER, Auteur ; Daniel P. DICKSTEIN, Auteur ; Melissa A. BROTMAN, Auteur ; Daniel Samuel PINE, Auteur ; Ellen LEIBENLUFT, Auteur . - 2012 . - p.1149-1156. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1149-1156 Mots-clés : Severe mood dysregulation  bipolar disorder  pediatric  longitudinal  neuroimaging  voxel-based morphometry  Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Background:  There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV. Methods:  An optimized, modulated voxel-based morphometry (VBM) analysis was conducted on structural MRI scans from 201 children (78 SMD, 55 BD, and 68 HV). In addition, 92 children (31 SMD, 34 BD, and 27 HV) were rescanned after 2 years (mean interval 1.99 ± 0.94 years), to compare time-related changes among the three groups. Results:  Cross-sectionally, the groups differed in gray matter (GM) volume in presupplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), insula, and globus pallidus. The cortical differences were driven mainly by increased GM volume in HV compared with BD and SMD. In globus pallidus, there was increased GM in BD compared with HV and SMD. Longitudinally, group-by-time interactions were evident in two clusters in the superior/inferior parietal lobule (R SPL/IPL) and in the precuneus. In both clusters, the interactions were driven by an abnormal increase in volume in BD. Conclusions:  Cross-sectionally, both BD and SMD are associated with structural abnormalities in frontal cortex, insula, and basal ganglia. Although some of these deficits overlap (insula and DLPFC), others differentiate SMD and BD (pre-SMA and globus pallidus). Abnormal developmental trajectories in lateral parietal cortex and precuneus are present in, and unique to, BD. Because of the high proportion of co-occurring ADHD in the SMD subjects, we could not separate effects of ADHD from those of SMD, and future research including a nonirritable ADHD group must address this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

Family-focused cognitive behavioral treatment for depressed adolescents in suicidal crisis with co-occurring risk factors: a randomized trial / C. ESPOSITO-SMYTHERS in Journal of Child Psychology and Psychiatry, 60-10 (October 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1133-1141 Titre : Family-focused cognitive behavioral treatment for depressed adolescents in suicidal crisis with co-occurring risk factors: a randomized trial Type de document : Texte imprimé et/ou numérique Auteurs : C. ESPOSITO-SMYTHERS, Auteur ; J. C. WOLFF, Auteur ; R. T. LIU, Auteur ; J. I. HUNT, Auteur ; L. ADAMS, Auteur ; K. KIM, Auteur ; E. A. FRAZIER, Auteur ; S. YEN, Auteur ; Daniel P. DICKSTEIN, Auteur ; A. SPIRITO, Auteur Article en page(s) : p.1133-1141 Langues : Anglais (eng) Mots-clés : Suicide  adolescent  clinical trial  cognitive behavioral therapy Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicide is the second leading cause of death among adolescents. The purpose of this study was to test a family-focused outpatient cognitive behavioral treatment (F-CBT) protocol for depressed adolescents following psychiatric hospitalization for a suicide attempt or suicidal ideation, and who had a co-occurring risk factor (suicidal behavior prior to the index admission, nonsuicidal self-injury, and/or a substance use disorder), in a randomized Phase 2 efficacy trial. METHOD: One hundred forty-seven adolescents (mean age = 14.91 years; 76.2% female, 85.5% White) and their families, recruited primarily from an inpatient psychiatric hospitalization program, were randomly assigned to F-CBT or enhanced treatment-as-usual (E-TAU). A suicide attempt was the primary outcome variable. Depression, suicidal ideation, and nonsuicidal self-injury are also reported here. Assessments were completed at pretreatment as well as 6, 12, and 18-months postrandomization (Trial Registration ClinicalTrials.gov Identifier: NCT01732601). RESULTS: In the sample as a whole, rates of attempts decreased from 20% at 6 months to 9% at 12 months to 7% at 18 months. There was no evidence of a significant difference between treatment arms in rates of suicide attempts, major depressive disorder, suicidal ideation, or nonsuicidal self-injury at any of the postrandomization assessment points. CONCLUSIONS: Though F-CBT was associated with reductions in suicidality, depression, and nonsuicidal self-injury, E-TAU showed an equally strong effect. Greater frequency of F-CBT treatment sessions, particularly at the start of care, and alternative approaches to transitioning to care at 12 months, may be necessary when using F-CBT with this population. En ligne : http://dx.doi.org/10.1111/jcpp.13095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Family-focused cognitive behavioral treatment for depressed adolescents in suicidal crisis with co-occurring risk factors: a randomized trial [Texte imprimé et/ou numérique] / C. ESPOSITO-SMYTHERS, Auteur ; J. C. WOLFF, Auteur ; R. T. LIU, Auteur ; J. I. HUNT, Auteur ; L. ADAMS, Auteur ; K. KIM, Auteur ; E. A. FRAZIER, Auteur ; S. YEN, Auteur ; Daniel P. DICKSTEIN, Auteur ; A. SPIRITO, Auteur . - p.1133-1141. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1133-1141 Mots-clés : Suicide  adolescent  clinical trial  cognitive behavioral therapy Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicide is the second leading cause of death among adolescents. The purpose of this study was to test a family-focused outpatient cognitive behavioral treatment (F-CBT) protocol for depressed adolescents following psychiatric hospitalization for a suicide attempt or suicidal ideation, and who had a co-occurring risk factor (suicidal behavior prior to the index admission, nonsuicidal self-injury, and/or a substance use disorder), in a randomized Phase 2 efficacy trial. METHOD: One hundred forty-seven adolescents (mean age = 14.91 years; 76.2% female, 85.5% White) and their families, recruited primarily from an inpatient psychiatric hospitalization program, were randomly assigned to F-CBT or enhanced treatment-as-usual (E-TAU). A suicide attempt was the primary outcome variable. Depression, suicidal ideation, and nonsuicidal self-injury are also reported here. Assessments were completed at pretreatment as well as 6, 12, and 18-months postrandomization (Trial Registration ClinicalTrials.gov Identifier: NCT01732601). RESULTS: In the sample as a whole, rates of attempts decreased from 20% at 6 months to 9% at 12 months to 7% at 18 months. There was no evidence of a significant difference between treatment arms in rates of suicide attempts, major depressive disorder, suicidal ideation, or nonsuicidal self-injury at any of the postrandomization assessment points. CONCLUSIONS: Though F-CBT was associated with reductions in suicidality, depression, and nonsuicidal self-injury, E-TAU showed an equally strong effect. Greater frequency of F-CBT treatment sessions, particularly at the start of care, and alternative approaches to transitioning to care at 12 months, may be necessary when using F-CBT with this population. En ligne : http://dx.doi.org/10.1111/jcpp.13095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit / Brendan A. RICH in Journal of Child Psychology and Psychiatry, 49-1 (January 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-1 (January 2008) . - p.88–96 Titre : Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit Type de document : Texte imprimé et/ou numérique Auteurs : Brendan A. RICH, Auteur ; Daniel Samuel PINE, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Stephen J. FROMM, Auteur ; Lisa H. BERGHORST, Auteur ; Daniel P. DICKSTEIN, Auteur Année de publication : 2007 Article en page(s) : p.88–96 Langues : Anglais (eng) Mots-clés : Bipolar-disorder children face-perception neural-connectivity amygdala Index. décimale : PER Périodiques Résumé : Background: Pediatric bipolar disorder (BD), a highly debilitating illness, is characterized by amygdala abnormalities, i.e., volume reduction and hyperactivation during face processing. Evidence of perturbed amygdala functional connectivity with other brain regions would implicate a distributed neural circuit in the pathophysiology of BD, and would further elucidate the neural mechanisms associated with BD face emotion misinterpretation. Methods: Thirty-three BD and 24 healthy age, gender, and IQ-matched subjects completed a functional magnetic resonance imaging (fMRI) task of face emotion identification in which attention was directed to emotional (hostility, fearfulness) and nonemotional (nose width) aspects of faces. Voxel-wise analyses examined whole brain functional connectivity with the left amygdala. Results: Compared to healthy subjects, BD subjects had significantly reduced connectivity between the left amygdala and two regions: right posterior cingulate/precuneus and right fusiform gyrus/parahippocampal gyrus. Deficits were evident regardless of mood state and comorbid diagnoses. Conclusions: BD youth exhibit deficient connectivity between the amygdala and temporal association cortical regions previously implicated in processing facial expressions and social stimuli. In conjunction with previously documented volumetric and functional perturbations in these brain regions, dysfunction in this distributed neural circuit may begin to clarify the pathophysiology of the face emotion misperceptions and social deficits seen in BD youth. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01819.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit [Texte imprimé et/ou numérique] / Brendan A. RICH, Auteur ; Daniel Samuel PINE, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Stephen J. FROMM, Auteur ; Lisa H. BERGHORST, Auteur ; Daniel P. DICKSTEIN, Auteur . - 2007 . - p.88–96. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-1 (January 2008) . - p.88–96 Mots-clés : Bipolar-disorder children face-perception neural-connectivity amygdala Index. décimale : PER Périodiques Résumé : Background: Pediatric bipolar disorder (BD), a highly debilitating illness, is characterized by amygdala abnormalities, i.e., volume reduction and hyperactivation during face processing. Evidence of perturbed amygdala functional connectivity with other brain regions would implicate a distributed neural circuit in the pathophysiology of BD, and would further elucidate the neural mechanisms associated with BD face emotion misinterpretation. Methods: Thirty-three BD and 24 healthy age, gender, and IQ-matched subjects completed a functional magnetic resonance imaging (fMRI) task of face emotion identification in which attention was directed to emotional (hostility, fearfulness) and nonemotional (nose width) aspects of faces. Voxel-wise analyses examined whole brain functional connectivity with the left amygdala. Results: Compared to healthy subjects, BD subjects had significantly reduced connectivity between the left amygdala and two regions: right posterior cingulate/precuneus and right fusiform gyrus/parahippocampal gyrus. Deficits were evident regardless of mood state and comorbid diagnoses. Conclusions: BD youth exhibit deficient connectivity between the amygdala and temporal association cortical regions previously implicated in processing facial expressions and social stimuli. In conjunction with previously documented volumetric and functional perturbations in these brain regions, dysfunction in this distributed neural circuit may begin to clarify the pathophysiology of the face emotion misperceptions and social deficits seen in BD youth. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01819.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

Self-injurious implicit attitudes among adolescent suicide attempters versus those engaged in nonsuicidal self-injury / Daniel P. DICKSTEIN in Journal of Child Psychology and Psychiatry, 56-10 (October 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-10 (October 2015) . - p.1127-1136 Titre : Self-injurious implicit attitudes among adolescent suicide attempters versus those engaged in nonsuicidal self-injury Type de document : Texte imprimé et/ou numérique Auteurs : Daniel P. DICKSTEIN, Auteur ; Megan E. PUZIA, Auteur ; Grace K. CUSHMAN, Auteur ; Alexandra B. WEISSMAN, Auteur ; Ezra WEGBREIT, Auteur ; Kerri L. KIM, Auteur ; Matthew K. NOCK, Auteur ; Anthony SPIRITO, Auteur Article en page(s) : p.1127-1136 Langues : Anglais (eng) Mots-clés : Suicide  nonsuicidal self-injury  adolescent  cognition Index. décimale : PER Périodiques Résumé : Background Suicide is among the most important mental health issues affecting adolescents today despite much research on its detection and prevention. Beyond suicide attempts (SAs), clinicians are increasingly confronted with another, potentially related problem: non-suicidal self-injury (NSSI)—defined as the deliberate destruction of body tissue without intent to die. NSSI may increase risk for making an SA by sevenfold, but many studies examining this link have involved youths engaging in both NSSI and SAs. Thus, there is a need to compare homogeneous groups of adolescents engaged in NSSI-only or SA-only, but not both, to advance what is known about each form of self-harm. The self-injurious implicit association task (SI-IAT) is a particularly important computerized behavioral task to study such adolescents because the SI-IAT provides objective behavioral data about problems for which people may lack insight or be motivated to conceal, such as SAs and NSSI. Methods We evaluated implicit associations with cutting and death/suicide using the computerized SI-IAT in three mutually exclusive groups: (1) adolescents who made an SA but had never engaged in NSSI (n = 47); (2) adolescents who engaged in NSSI but had never made an SA (n = 46); and (3) typically developing control (TDC) adolescents without history of psychiatric problems (n = 43). Results Nonsuicidal self-injury participants had stronger identification with cutting versus no cutting than either SA or TDC participants. Contrary to our hypothesis, NSSI participants had stronger identification with suicide/death versus life than either SA or TDC participants. Conclusions Strong implicit attitudes towards suicide/death among adolescents with NSSI without a prior SA suggest that clinicians should not dismiss NSSI as not serious. Further work is required to elucidate the mechanism by which youths engaged in NSSI acquire these stronger identifications and make a first-time SA to develop novel treatment and prevention strategies blocking this transformation, ultimately reducing youth suicide. En ligne : http://dx.doi.org/10.1111/jcpp.12385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269 [article] Self-injurious implicit attitudes among adolescent suicide attempters versus those engaged in nonsuicidal self-injury [Texte imprimé et/ou numérique] / Daniel P. DICKSTEIN, Auteur ; Megan E. PUZIA, Auteur ; Grace K. CUSHMAN, Auteur ; Alexandra B. WEISSMAN, Auteur ; Ezra WEGBREIT, Auteur ; Kerri L. KIM, Auteur ; Matthew K. NOCK, Auteur ; Anthony SPIRITO, Auteur . - p.1127-1136. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-10 (October 2015) . - p.1127-1136 Mots-clés : Suicide  nonsuicidal self-injury  adolescent  cognition Index. décimale : PER Périodiques Résumé : Background Suicide is among the most important mental health issues affecting adolescents today despite much research on its detection and prevention. Beyond suicide attempts (SAs), clinicians are increasingly confronted with another, potentially related problem: non-suicidal self-injury (NSSI)—defined as the deliberate destruction of body tissue without intent to die. NSSI may increase risk for making an SA by sevenfold, but many studies examining this link have involved youths engaging in both NSSI and SAs. Thus, there is a need to compare homogeneous groups of adolescents engaged in NSSI-only or SA-only, but not both, to advance what is known about each form of self-harm. The self-injurious implicit association task (SI-IAT) is a particularly important computerized behavioral task to study such adolescents because the SI-IAT provides objective behavioral data about problems for which people may lack insight or be motivated to conceal, such as SAs and NSSI. Methods We evaluated implicit associations with cutting and death/suicide using the computerized SI-IAT in three mutually exclusive groups: (1) adolescents who made an SA but had never engaged in NSSI (n = 47); (2) adolescents who engaged in NSSI but had never made an SA (n = 46); and (3) typically developing control (TDC) adolescents without history of psychiatric problems (n = 43). Results Nonsuicidal self-injury participants had stronger identification with cutting versus no cutting than either SA or TDC participants. Contrary to our hypothesis, NSSI participants had stronger identification with suicide/death versus life than either SA or TDC participants. Conclusions Strong implicit attitudes towards suicide/death among adolescents with NSSI without a prior SA suggest that clinicians should not dismiss NSSI as not serious. Further work is required to elucidate the mechanism by which youths engaged in NSSI acquire these stronger identifications and make a first-time SA to develop novel treatment and prevention strategies blocking this transformation, ultimately reducing youth suicide. En ligne : http://dx.doi.org/10.1111/jcpp.12385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269

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