Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum / Stephanie PEDRAHITA in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70208 Titre : Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum Type de document : texte imprimé Auteurs : Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur Article en page(s) : e70208 Langues : Anglais (eng) Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum [texte imprimé] / Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur . - e70208. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70208 Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Externalizing Behaviors are Associated with Increased Parenting Stress in Caregivers of Young Children with Autism / Lindsay OLSON in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.975-986 Titre : Externalizing Behaviors are Associated with Increased Parenting Stress in Caregivers of Young Children with Autism Type de document : texte imprimé Auteurs : Lindsay OLSON, Auteur ; Bosi CHEN, Auteur ; Cynthia IBARRA, Auteur ; Tiffany WANG, Auteur ; Lisa E. MASH, Auteur ; Annika LINKE, Auteur ; Mikaela KINNEAR, Auteur ; Inna FISHMAN, Auteur Article en page(s) : p.975-986 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Caregivers  Child  Child, Preschool  Humans  Parenting  Parents  Asd  Early childhood  Externalizing behaviors  Parental stress Index. décimale : PER Périodiques Résumé : Parents of children diagnosed with autism spectrum disorder (ASD) report higher levels of stress than parents of typically developing children. Few studies have examined factors associated with parental stress in early childhood. Even fewer have investigated the simultaneous influence of sociodemographic, clinical, and developmental variables on parental stress. We examined factors associated with stress in parents of young children with ASD. Multiple regression models were used to test for associations between socioeconomic indices, developmental measures, and parental stress. Externalizing behaviors, communication, and socialization skills accounted for variance in parental stress, controlling for ASD diagnosis. Results highlight the importance of interventions aimed at reducing externalizing behaviors in young children as well as addressing stress in caregivers of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04995-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Externalizing Behaviors are Associated with Increased Parenting Stress in Caregivers of Young Children with Autism [texte imprimé] / Lindsay OLSON, Auteur ; Bosi CHEN, Auteur ; Cynthia IBARRA, Auteur ; Tiffany WANG, Auteur ; Lisa E. MASH, Auteur ; Annika LINKE, Auteur ; Mikaela KINNEAR, Auteur ; Inna FISHMAN, Auteur . - p.975-986. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.975-986 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Caregivers  Child  Child, Preschool  Humans  Parenting  Parents  Asd  Early childhood  Externalizing behaviors  Parental stress Index. décimale : PER Périodiques Résumé : Parents of children diagnosed with autism spectrum disorder (ASD) report higher levels of stress than parents of typically developing children. Few studies have examined factors associated with parental stress in early childhood. Even fewer have investigated the simultaneous influence of sociodemographic, clinical, and developmental variables on parental stress. We examined factors associated with stress in parents of young children with ASD. Multiple regression models were used to test for associations between socioeconomic indices, developmental measures, and parental stress. Externalizing behaviors, communication, and socialization skills accounted for variance in parental stress, controlling for ASD diagnosis. Results highlight the importance of interventions aimed at reducing externalizing behaviors in young children as well as addressing stress in caregivers of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04995-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism / Ryan TUNG in Autism Research, 14-10 (October 2021)  

Public ISBD [article]  inAutism Research > 14-10 (October 2021) . - p.2100-2112 Titre : Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism Type de document : texte imprimé Auteurs : Ryan TUNG, Auteur ; Maya A. REITER, Auteur ; Annika LINKE, Auteur ; Jiwandeep S. KOHLI, Auteur ; Mikaela KINNEAR, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth A. CARPER, Auteur Article en page(s) : p.2100-2112 Langues : Anglais (eng) Mots-clés : Adult  Anxiety/complications/diagnostic imaging  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder/complications/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Humans  Magnetic Resonance Imaging  Male  Middle Aged  Neural Pathways/diagnostic imaging  Asd  adults  anxiety  autism  functional connectivity  resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q < 0.1 (corrected) and p < 0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism [texte imprimé] / Ryan TUNG, Auteur ; Maya A. REITER, Auteur ; Annika LINKE, Auteur ; Jiwandeep S. KOHLI, Auteur ; Mikaela KINNEAR, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth A. CARPER, Auteur . - p.2100-2112. Langues : Anglais (eng) in Autism Research > 14-10 (October 2021) . - p.2100-2112 Mots-clés : Adult  Anxiety/complications/diagnostic imaging  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder/complications/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Humans  Magnetic Resonance Imaging  Male  Middle Aged  Neural Pathways/diagnostic imaging  Asd  adults  anxiety  autism  functional connectivity  resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q < 0.1 (corrected) and p < 0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Greater functional connectivity between sensory networks is related to symptom severity in toddlers with autism spectrum disorder / Bosi CHEN in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.160-170 Titre : Greater functional connectivity between sensory networks is related to symptom severity in toddlers with autism spectrum disorder Type de document : texte imprimé Auteurs : Bosi CHEN, Auteur ; Annika LINKE, Auteur ; Lindsay OLSON, Auteur ; Cynthia IBARRA, Auteur ; Sarah REYNOLDS, Auteur ; Ralph-Axel MULLER, Auteur ; Mikaela KINNEAR, Auteur ; Inna FISHMAN, Auteur Année de publication : 2021 Article en page(s) : p.160-170 Langues : Anglais (eng) Mots-clés : Brain networks  autism spectrum disorders  early childhood  functional connectivity  neuroimaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Symptoms of autism spectrum disorder (ASD) emerge in the first years of life. Yet, little is known about the organization and development of functional brain networks in ASD proximally to the symptom onset. Further, the relationship between brain network connectivity and emerging ASD symptoms and overall functioning in early childhood is not well understood. METHODS: Resting-state fMRI data were acquired during natural sleep from 24 young children with ASD and 23 typically developing (TD) children, aged 17-45 months. Intrinsic functional connectivity (iFC) within and between resting-state functional networks was derived with independent component analysis (ICA). RESULTS: Increased iFC between visual and sensorimotor networks was found in young children with ASD compared to TD participants. Within the ASD group, the degree of overconnectivity between visual and sensorimotor networks was associated with greater autism symptoms. Age-related weakening of the visual-auditory between-network connectivity was observed in the ASD but not the TD group. CONCLUSIONS: Taken together, these results provide evidence for disrupted functional network maturation and differentiation, particularly involving visual and sensorimotor networks, during the first years of life in ASD. The observed pattern of greater visual-sensorimotor between-network connectivity associated with poorer clinical outcomes suggests that disruptions in multisensory brain circuitry may play a critical role for early development of behavioral skills and autism symptomatology in young children with ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13268 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Greater functional connectivity between sensory networks is related to symptom severity in toddlers with autism spectrum disorder [texte imprimé] / Bosi CHEN, Auteur ; Annika LINKE, Auteur ; Lindsay OLSON, Auteur ; Cynthia IBARRA, Auteur ; Sarah REYNOLDS, Auteur ; Ralph-Axel MULLER, Auteur ; Mikaela KINNEAR, Auteur ; Inna FISHMAN, Auteur . - 2021 . - p.160-170. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.160-170 Mots-clés : Brain networks  autism spectrum disorders  early childhood  functional connectivity  neuroimaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Symptoms of autism spectrum disorder (ASD) emerge in the first years of life. Yet, little is known about the organization and development of functional brain networks in ASD proximally to the symptom onset. Further, the relationship between brain network connectivity and emerging ASD symptoms and overall functioning in early childhood is not well understood. METHODS: Resting-state fMRI data were acquired during natural sleep from 24 young children with ASD and 23 typically developing (TD) children, aged 17-45 months. Intrinsic functional connectivity (iFC) within and between resting-state functional networks was derived with independent component analysis (ICA). RESULTS: Increased iFC between visual and sensorimotor networks was found in young children with ASD compared to TD participants. Within the ASD group, the degree of overconnectivity between visual and sensorimotor networks was associated with greater autism symptoms. Age-related weakening of the visual-auditory between-network connectivity was observed in the ASD but not the TD group. CONCLUSIONS: Taken together, these results provide evidence for disrupted functional network maturation and differentiation, particularly involving visual and sensorimotor networks, during the first years of life in ASD. The observed pattern of greater visual-sensorimotor between-network connectivity associated with poorer clinical outcomes suggests that disruptions in multisensory brain circuitry may play a critical role for early development of behavioral skills and autism symptomatology in young children with ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13268 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

Sex-related patterns of intrinsic functional connectivity in children and adolescents with autism spectrum disorders / Lindsay OLSON in Autism, 24-8 (November 2020)  

Public ISBD [article]  inAutism > 24-8 (November 2020) . - p.2190-2201 Titre : Sex-related patterns of intrinsic functional connectivity in children and adolescents with autism spectrum disorders Type de document : texte imprimé Auteurs : Lindsay OLSON, Auteur ; Lisa E. MASH, Auteur ; Annika LINKE, Auteur ; Christopher H. FONG, Auteur ; Ralph-Axel MULLER, Auteur ; Inna FISHMAN, Auteur Article en page(s) : p.2190-2201 Langues : Anglais (eng) Mots-clés : *autism spectrum disorders  *brain function  *school-age children  interest to report. Index. décimale : PER Périodiques Résumé : We investigated whether children and adolescents with autism spectrum disorders show sex-specific patterns of brain function (using functional magnetic resonance imaging) that are well documented in typically developing males and females. We found, unexpectedly, that boys and girls with autism do not differ in their brain functional connectivity, whereas typically developing boys and girls showed differences in a brain network involved in thinking about self and others (the default mode network). Results suggest that autism may be characterized by a lack of brain sex differentiation. En ligne : http://dx.doi.org/10.1177/1362361320938194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Sex-related patterns of intrinsic functional connectivity in children and adolescents with autism spectrum disorders [texte imprimé] / Lindsay OLSON, Auteur ; Lisa E. MASH, Auteur ; Annika LINKE, Auteur ; Christopher H. FONG, Auteur ; Ralph-Axel MULLER, Auteur ; Inna FISHMAN, Auteur . - p.2190-2201. Langues : Anglais (eng) in Autism > 24-8 (November 2020) . - p.2190-2201 Mots-clés : *autism spectrum disorders  *brain function  *school-age children  interest to report. Index. décimale : PER Périodiques Résumé : We investigated whether children and adolescents with autism spectrum disorders show sex-specific patterns of brain function (using functional magnetic resonance imaging) that are well documented in typically developing males and females. We found, unexpectedly, that boys and girls with autism do not differ in their brain functional connectivity, whereas typically developing boys and girls showed differences in a brain network involved in thinking about self and others (the default mode network). Results suggest that autism may be characterized by a lack of brain sex differentiation. En ligne : http://dx.doi.org/10.1177/1362361320938194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

The language network in autism: Atypical functional connectivity with default mode and visual regions / Yangfeifei GAO in Autism Research, 12-9 (September 2019)  

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