Atypical maturation of the functional connectome hierarchy in autism / Sunghun KIM ; Shinwon PARK ; Hyoungshin CHOI ; Bo-Yong PARK ; Hyunjin PARK in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 21 Titre : Atypical maturation of the functional connectome hierarchy in autism Type de document : Texte imprimé et/ou numérique Auteurs : Sunghun KIM, Auteur ; Shinwon PARK, Auteur ; Hyoungshin CHOI, Auteur ; Bo-Yong PARK, Auteur ; Hyunjin PARK, Auteur Article en page(s) : 21 Langues : Anglais (eng) Mots-clés : Humans  Connectome  Adolescent  Child  Male  Young Adult  Female  Magnetic Resonance Imaging  Brain/diagnostic imaging/physiopathology  Child, Preschool  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Autistic Disorder/physiopathology/diagnostic imaging  Adult  Autism spectrum disorder  Cortical hierarchy  Integration and segregation  Normative modeling Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is marked by disruptions in low-level sensory processing and higher-order sociocognitive functions, suggesting a complex interplay between different brain regions across the cortical hierarchy. However, the developmental trajectory of this hierarchical organization in ASD remains underexplored. Herein, we investigated the maturational abnormalities in the cortical hierarchy among individuals with ASD. METHODS: Resting-state functional magnetic resonance imaging data from three large-scale datasets were analyzed: Autism Brain Imaging Data Exchange I and II and Lifespan Human Connectome Project Development (aged 5-22 years). The principal functional connectivity gradient representing cortical hierarchy was estimated using diffusion map embedding. By applying normative modeling with the generalized additive model for location, scale, and shape (GAMLSS), we captured the nonlinear trajectories of the developing functional gradient, as well as the individual-level deviations in ASD from typical development based on centile scores measured as deviations from the normative curves. A whole-brain summary metric, the functional hierarchy score, was derived to measure the extent of abnormal maturation in individuals with ASD. Finally, through a series of mediation analyses, we examined the potential role of network-level connectomic disruptions between the diagnoses and deviations in the cortical hierarchy. RESULTS: The maturation of cortical hierarchy in individuals with ASD followed a non-linear trajectory, showing delayed maturation during childhood compared to that of typically developing individuals, followed by an accelerated "catch-up" phase during adolescence and a subsequent decline in young adulthood. The nature of these deviations varied across networks, with sensory and attention networks displaying the most pronounced abnormalities in childhood, while higher-order networks, particularly the default mode network (DMN), remaining impaired from childhood to adolescence. Mediation analyses revealed that the persistent reduction in DMN segregation throughout development was a key contributor to the atypical development of cortical hierarchy in ASD. LIMITATIONS: The uneven distribution of samples across age groups, particularly in the later stages of development, limited our ability to fully capture developmental trajectories among older individuals. CONCLUSIONS: These findings highlight the importance of understanding the developmental trajectories of cortical organization in ASD, collectively suggesting that early interventions aimed at promoting the normative development of higher-order networks may be critical for improving outcomes in individuals with ASD. En ligne : https://dx.doi.org/10.1186/s13229-025-00641-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Atypical maturation of the functional connectome hierarchy in autism [Texte imprimé et/ou numérique] / Sunghun KIM, Auteur ; Shinwon PARK, Auteur ; Hyoungshin CHOI, Auteur ; Bo-Yong PARK, Auteur ; Hyunjin PARK, Auteur . - 21. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 21 Mots-clés : Humans  Connectome  Adolescent  Child  Male  Young Adult  Female  Magnetic Resonance Imaging  Brain/diagnostic imaging/physiopathology  Child, Preschool  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Autistic Disorder/physiopathology/diagnostic imaging  Adult  Autism spectrum disorder  Cortical hierarchy  Integration and segregation  Normative modeling Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is marked by disruptions in low-level sensory processing and higher-order sociocognitive functions, suggesting a complex interplay between different brain regions across the cortical hierarchy. However, the developmental trajectory of this hierarchical organization in ASD remains underexplored. Herein, we investigated the maturational abnormalities in the cortical hierarchy among individuals with ASD. METHODS: Resting-state functional magnetic resonance imaging data from three large-scale datasets were analyzed: Autism Brain Imaging Data Exchange I and II and Lifespan Human Connectome Project Development (aged 5-22 years). The principal functional connectivity gradient representing cortical hierarchy was estimated using diffusion map embedding. By applying normative modeling with the generalized additive model for location, scale, and shape (GAMLSS), we captured the nonlinear trajectories of the developing functional gradient, as well as the individual-level deviations in ASD from typical development based on centile scores measured as deviations from the normative curves. A whole-brain summary metric, the functional hierarchy score, was derived to measure the extent of abnormal maturation in individuals with ASD. Finally, through a series of mediation analyses, we examined the potential role of network-level connectomic disruptions between the diagnoses and deviations in the cortical hierarchy. RESULTS: The maturation of cortical hierarchy in individuals with ASD followed a non-linear trajectory, showing delayed maturation during childhood compared to that of typically developing individuals, followed by an accelerated "catch-up" phase during adolescence and a subsequent decline in young adulthood. The nature of these deviations varied across networks, with sensory and attention networks displaying the most pronounced abnormalities in childhood, while higher-order networks, particularly the default mode network (DMN), remaining impaired from childhood to adolescence. Mediation analyses revealed that the persistent reduction in DMN segregation throughout development was a key contributor to the atypical development of cortical hierarchy in ASD. LIMITATIONS: The uneven distribution of samples across age groups, particularly in the later stages of development, limited our ability to fully capture developmental trajectories among older individuals. CONCLUSIONS: These findings highlight the importance of understanding the developmental trajectories of cortical organization in ASD, collectively suggesting that early interventions aimed at promoting the normative development of higher-order networks may be critical for improving outcomes in individuals with ASD. En ligne : https://dx.doi.org/10.1186/s13229-025-00641-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Contracted functional connectivity profiles in autism / Clara F. WEBER in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 38p. Titre : Contracted functional connectivity profiles in autism Type de document : Texte imprimé et/ou numérique Auteurs : Clara F. WEBER, Auteur ; Valeria KEBETS, Auteur ; Oualid BENKARIM, Auteur ; Sara LARIVIERE, Auteur ; Yezhou WANG, Auteur ; Alexander NGO, Auteur ; Hongxiu JIANG, Auteur ; Xiaoqian CHAI, Auteur ; Bo-Yong PARK, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur ; Sofie VALK, Auteur ; Seok-Jun HONG, Auteur ; Boris C. BERNHARDT, Auteur Article en page(s) : 38p. Langues : Anglais (eng) Mots-clés : Humans  Male  Connectome  Young Adult  Adult  Magnetic Resonance Imaging  Adolescent  Autism Spectrum Disorder/physiopathology/diagnostic imaging  Autistic Disorder/physiopathology/diagnostic imaging  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Nerve Net/diagnostic imaging/physiopathology  Neural Pathways/physiopathology/diagnostic imaging  Autism spectrum disorder  Connectivity disruptions  Distance profiling  Functional connectivity  Magnetic resonance imaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : OBJECTIVE: Autism spectrum disorder (ASD) is a neurodevelopmental condition that is associated with atypical brain network organization, with prior work suggesting differential connectivity alterations with respect to functional connection length. Here, we tested whether functional connectopathy in ASD specifically relates to disruptions in long- relative to short-range functional connections. Our approach combined functional connectomics with geodesic distance mapping, and we studied associations to macroscale networks, microarchitectural patterns, as well as socio-demographic and clinical phenotypes. METHODS: We studied 211 males from three sites of the ABIDE-I dataset comprising 103 participants with an ASD diagnosis (mean?+?SD age = 20.8?+?8.1 years) and 108 neurotypical controls (NT, 19.2?+?7.2 years). For each participant, we computed cortex-wide connectivity distance (CD) measures by combining geodesic distance mapping with resting-state functional connectivity profiling. We compared CD between ASD and NT participants using surface-based linear models, and studied associations with age, symptom severity, and intelligence scores. We contextualized CD alterations relative to canonical networks and explored spatial associations with functional and microstructural cortical gradients as well as cytoarchitectonic cortical types. RESULTS: Compared to NT, ASD participants presented with widespread reductions in CD, generally indicating shorter average connection length and thus suggesting reduced long-range connectivity but increased short-range connections. Peak reductions were localized in transmodal systems (i.e., heteromodal and paralimbic regions in the prefrontal, temporal, and parietal and temporo-parieto-occipital cortex), and effect sizes correlated with the sensory-transmodal gradient of brain function. ASD-related CD reductions appeared consistent across inter-individual differences in age and symptom severity, and we observed a positive correlation of CD to IQ scores. LIMITATIONS: Despite rigorous harmonization across the three different acquisition sites, heterogeneity in autism poses a potential limitation to the generalizability of our results. Additionally, we focussed male participants, warranting future studies in more balanced cohorts. CONCLUSIONS: Our study showed reductions in CD as a relatively stable imaging phenotype of ASD that preferentially impacted paralimbic and heteromodal association systems. CD reductions in ASD corroborate previous reports of ASD-related imbalance between short-range overconnectivity and long-range underconnectivity. En ligne : https://dx.doi.org/10.1186/s13229-024-00616-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Contracted functional connectivity profiles in autism [Texte imprimé et/ou numérique] / Clara F. WEBER, Auteur ; Valeria KEBETS, Auteur ; Oualid BENKARIM, Auteur ; Sara LARIVIERE, Auteur ; Yezhou WANG, Auteur ; Alexander NGO, Auteur ; Hongxiu JIANG, Auteur ; Xiaoqian CHAI, Auteur ; Bo-Yong PARK, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur ; Sofie VALK, Auteur ; Seok-Jun HONG, Auteur ; Boris C. BERNHARDT, Auteur . - 38p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 38p. Mots-clés : Humans  Male  Connectome  Young Adult  Adult  Magnetic Resonance Imaging  Adolescent  Autism Spectrum Disorder/physiopathology/diagnostic imaging  Autistic Disorder/physiopathology/diagnostic imaging  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Nerve Net/diagnostic imaging/physiopathology  Neural Pathways/physiopathology/diagnostic imaging  Autism spectrum disorder  Connectivity disruptions  Distance profiling  Functional connectivity  Magnetic resonance imaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : OBJECTIVE: Autism spectrum disorder (ASD) is a neurodevelopmental condition that is associated with atypical brain network organization, with prior work suggesting differential connectivity alterations with respect to functional connection length. Here, we tested whether functional connectopathy in ASD specifically relates to disruptions in long- relative to short-range functional connections. Our approach combined functional connectomics with geodesic distance mapping, and we studied associations to macroscale networks, microarchitectural patterns, as well as socio-demographic and clinical phenotypes. METHODS: We studied 211 males from three sites of the ABIDE-I dataset comprising 103 participants with an ASD diagnosis (mean?+?SD age = 20.8?+?8.1 years) and 108 neurotypical controls (NT, 19.2?+?7.2 years). For each participant, we computed cortex-wide connectivity distance (CD) measures by combining geodesic distance mapping with resting-state functional connectivity profiling. We compared CD between ASD and NT participants using surface-based linear models, and studied associations with age, symptom severity, and intelligence scores. We contextualized CD alterations relative to canonical networks and explored spatial associations with functional and microstructural cortical gradients as well as cytoarchitectonic cortical types. RESULTS: Compared to NT, ASD participants presented with widespread reductions in CD, generally indicating shorter average connection length and thus suggesting reduced long-range connectivity but increased short-range connections. Peak reductions were localized in transmodal systems (i.e., heteromodal and paralimbic regions in the prefrontal, temporal, and parietal and temporo-parieto-occipital cortex), and effect sizes correlated with the sensory-transmodal gradient of brain function. ASD-related CD reductions appeared consistent across inter-individual differences in age and symptom severity, and we observed a positive correlation of CD to IQ scores. LIMITATIONS: Despite rigorous harmonization across the three different acquisition sites, heterogeneity in autism poses a potential limitation to the generalizability of our results. Additionally, we focussed male participants, warranting future studies in more balanced cohorts. CONCLUSIONS: Our study showed reductions in CD as a relatively stable imaging phenotype of ASD that preferentially impacted paralimbic and heteromodal association systems. CD reductions in ASD corroborate previous reports of ASD-related imbalance between short-range overconnectivity and long-range underconnectivity. En ligne : https://dx.doi.org/10.1186/s13229-024-00616-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

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