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Auteur Evdokia ANAGNOSTOU |
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Development of a patient-centered conceptual model of the impact of living with autism spectrum disorder / F. MCDOUGALL in Autism, 22-8 (November 2018)
[article]
Titre : Development of a patient-centered conceptual model of the impact of living with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : F. MCDOUGALL, Auteur ; T. WILLGOSS, Auteur ; S. HWANG, Auteur ; Federico BOLOGNANI, Auteur ; L. MURTAGH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; D. ROFAIL, Auteur Article en page(s) : p.953-969 Langues : Anglais (eng) Mots-clés : autism spectrum disorder conceptual model qualitative research Index. décimale : PER Périodiques Résumé : The aim of this study was to generate a patient-centered conceptual model of the impact of living with autism spectrum disorder, which can be used to support the selection of outcome measures for clinical trials. Following an initial literature review to identify preliminary concepts and inform an interview guide, in-depth face-to-face interviews were conducted with adolescents and adults with autism spectrum disorder (IQ 70) (n = 10), as well as parents of children, adolescents, and adults with autism spectrum disorder (IQ 70) (n = 26). Data were analyzed using established qualitative research methods. The resultant conceptual model contains three interrelated domains reflecting core symptoms of autism spectrum disorder (communication deficits, socialization deficits, and restrictive, repetitive patterns of behavior), three domains reflecting associated symptoms of autism spectrum disorder (physical, cognitive, and emotional/behavioral), and three domains representing the impacts of living with autism spectrum disorder (impacts on activities of daily living, school/work, and social life). Interview respondents also cited social communication deficits as priority targets for new treatments. The conceptual model provides a patient-centered perspective of relevant concepts of autism spectrum disorder from the perspectives of people with autism spectrum disorder and their parents and offers a valuable tool for identifying valid patient-centered outcome measures for future clinical trials. En ligne : http://dx.doi.org/10.1177/1362361317718987 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370
in Autism > 22-8 (November 2018) . - p.953-969[article] Development of a patient-centered conceptual model of the impact of living with autism spectrum disorder [Texte imprimé et/ou numérique] / F. MCDOUGALL, Auteur ; T. WILLGOSS, Auteur ; S. HWANG, Auteur ; Federico BOLOGNANI, Auteur ; L. MURTAGH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; D. ROFAIL, Auteur . - p.953-969.
Langues : Anglais (eng)
in Autism > 22-8 (November 2018) . - p.953-969
Mots-clés : autism spectrum disorder conceptual model qualitative research Index. décimale : PER Périodiques Résumé : The aim of this study was to generate a patient-centered conceptual model of the impact of living with autism spectrum disorder, which can be used to support the selection of outcome measures for clinical trials. Following an initial literature review to identify preliminary concepts and inform an interview guide, in-depth face-to-face interviews were conducted with adolescents and adults with autism spectrum disorder (IQ 70) (n = 10), as well as parents of children, adolescents, and adults with autism spectrum disorder (IQ 70) (n = 26). Data were analyzed using established qualitative research methods. The resultant conceptual model contains three interrelated domains reflecting core symptoms of autism spectrum disorder (communication deficits, socialization deficits, and restrictive, repetitive patterns of behavior), three domains reflecting associated symptoms of autism spectrum disorder (physical, cognitive, and emotional/behavioral), and three domains representing the impacts of living with autism spectrum disorder (impacts on activities of daily living, school/work, and social life). Interview respondents also cited social communication deficits as priority targets for new treatments. The conceptual model provides a patient-centered perspective of relevant concepts of autism spectrum disorder from the perspectives of people with autism spectrum disorder and their parents and offers a valuable tool for identifying valid patient-centered outcome measures for future clinical trials. En ligne : http://dx.doi.org/10.1177/1362361317718987 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders / M. T. SIU in Journal of Autism and Developmental Disorders, 51-10 (October 2021)
[article]
Titre : DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : M. T. SIU, Auteur ; S. J. GOODMAN, Auteur ; I. YELLAN, Auteur ; D. T. BUTCHER, Auteur ; M. JANGJOO, Auteur ; D. GRAFODATSKAYA, Auteur ; R. RAJENDRAM, Auteur ; Y. LOU, Auteur ; R. ZHANG, Auteur ; C. ZHAO, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; P. SZATMARI, Auteur ; Stephen SCHERER, Auteur ; W. ROBERTS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. WEKSBERG, Auteur Article en page(s) : p.3610-3623 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics Autism Spectrum Disorder/genetics DNA Methylation Female Humans Male Obsessive-Compulsive Disorder Oxytocin/metabolism Receptors, Oxytocin/genetics Adhd Asd Ocd Oxtr Index. décimale : PER Périodiques Résumé : Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04792-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3610-3623[article] DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / M. T. SIU, Auteur ; S. J. GOODMAN, Auteur ; I. YELLAN, Auteur ; D. T. BUTCHER, Auteur ; M. JANGJOO, Auteur ; D. GRAFODATSKAYA, Auteur ; R. RAJENDRAM, Auteur ; Y. LOU, Auteur ; R. ZHANG, Auteur ; C. ZHAO, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; P. SZATMARI, Auteur ; Stephen SCHERER, Auteur ; W. ROBERTS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. WEKSBERG, Auteur . - p.3610-3623.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3610-3623
Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics Autism Spectrum Disorder/genetics DNA Methylation Female Humans Male Obsessive-Compulsive Disorder Oxytocin/metabolism Receptors, Oxytocin/genetics Adhd Asd Ocd Oxtr Index. décimale : PER Périodiques Résumé : Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04792-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 Effectiveness of a modified group cognitive behavioral therapy program for anxiety in children with ASD delivered in a community context / Abbie SOLISH in Molecular Autism, 11 (2020)
[article]
Titre : Effectiveness of a modified group cognitive behavioral therapy program for anxiety in children with ASD delivered in a community context Type de document : Texte imprimé et/ou numérique Auteurs : Abbie SOLISH, Auteur ; Nora KLEMENCIC, Auteur ; Anne RITZEMA, Auteur ; Vicki NOLAN, Auteur ; Martha PILKINGTON, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jessica BRIAN, Auteur Article en page(s) : 34 p. Langues : Anglais (eng) Mots-clés : Anxiety Autism Autism spectrum disorder Cognitive behavioral therapy Community Group Implementation Intervention Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with autism spectrum disorder (ASD) experience high rates (approximately 50-79%) of comorbid anxiety problems. Given the significant interference and distress that excessive anxiety can cause, evidence-based intervention is necessary in order to reduce long-term negative effects. Cognitive behavioral therapy (CBT) has demonstrated efficacy for treating anxiety disorders across the lifespan, both in individual and group formats. Recently, modified CBT programs for youth with ASD have been developed, showing positive outcomes. To date, these modified CBT programs have primarily been evaluated in controlled research settings. METHODS: The current community effectiveness study investigated the effectiveness of a modified group CBT program (Facing Your Fears) delivered in a tertiary care hospital and across six community-based agencies providing services for youth with ASD. Data were collected over six years (N = 105 youth with ASD; ages 6-15 years). RESULTS: Hospital and community samples did not differ significantly, except in terms of age (hospital M = 10.08 years; community M = 10.87 years). Results indicated significant improvements in anxiety levels from baseline to post-treatment across measures, with medium effect sizes. An attempt to uncover individual characteristics that predict response to treatment was unsuccessful. CONCLUSIONS: Overall, this study demonstrated that community implementation of a modified group CBT program for youth with ASD is feasible and effective for treating elevated anxiety. En ligne : http://dx.doi.org/10.1186/s13229-020-00341-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 34 p.[article] Effectiveness of a modified group cognitive behavioral therapy program for anxiety in children with ASD delivered in a community context [Texte imprimé et/ou numérique] / Abbie SOLISH, Auteur ; Nora KLEMENCIC, Auteur ; Anne RITZEMA, Auteur ; Vicki NOLAN, Auteur ; Martha PILKINGTON, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jessica BRIAN, Auteur . - 34 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 34 p.
Mots-clés : Anxiety Autism Autism spectrum disorder Cognitive behavioral therapy Community Group Implementation Intervention Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with autism spectrum disorder (ASD) experience high rates (approximately 50-79%) of comorbid anxiety problems. Given the significant interference and distress that excessive anxiety can cause, evidence-based intervention is necessary in order to reduce long-term negative effects. Cognitive behavioral therapy (CBT) has demonstrated efficacy for treating anxiety disorders across the lifespan, both in individual and group formats. Recently, modified CBT programs for youth with ASD have been developed, showing positive outcomes. To date, these modified CBT programs have primarily been evaluated in controlled research settings. METHODS: The current community effectiveness study investigated the effectiveness of a modified group CBT program (Facing Your Fears) delivered in a tertiary care hospital and across six community-based agencies providing services for youth with ASD. Data were collected over six years (N = 105 youth with ASD; ages 6-15 years). RESULTS: Hospital and community samples did not differ significantly, except in terms of age (hospital M = 10.08 years; community M = 10.87 years). Results indicated significant improvements in anxiety levels from baseline to post-treatment across measures, with medium effect sizes. An attempt to uncover individual characteristics that predict response to treatment was unsuccessful. CONCLUSIONS: Overall, this study demonstrated that community implementation of a modified group CBT program for youth with ASD is feasible and effective for treating elevated anxiety. En ligne : http://dx.doi.org/10.1186/s13229-020-00341-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Effects of Age and Attention on Auditory Global–Local Processing in Children with Autism Spectrum Disorder / Nicholas E. V. FOSTER in Journal of Autism and Developmental Disorders, 46-4 (April 2016)
[article]
Titre : Effects of Age and Attention on Auditory Global–Local Processing in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas E. V. FOSTER, Auteur ; Tia OUIMET, Auteur ; Ana TRYFON, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Krista L. HYDE, Auteur Article en page(s) : p.1415-1428 Langues : Anglais (eng) Mots-clés : Autism Auditory Development Attention Index. décimale : PER Périodiques Résumé : In vision, typically-developing (TD) individuals perceive “global” (whole) before “local” (detailed) features, whereas individuals with autism spectrum disorder (ASD) exhibit a local bias. However, auditory global–local distinctions are less clear in ASD, particularly in terms of age and attention effects. To these aims, here ASD and TD children judged local and global pitch structure in nine-tone melodies. Both groups showed a similar global precedence effect, but ASD children were less sensitive to global interference than TD children at younger ages. There was no effect of attention task. These findings provide novel evidence of developmental differences in auditory perception and may help to refine sensory phenotypes in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2684-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284
in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1415-1428[article] Effects of Age and Attention on Auditory Global–Local Processing in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Nicholas E. V. FOSTER, Auteur ; Tia OUIMET, Auteur ; Ana TRYFON, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Krista L. HYDE, Auteur . - p.1415-1428.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1415-1428
Mots-clés : Autism Auditory Development Attention Index. décimale : PER Périodiques Résumé : In vision, typically-developing (TD) individuals perceive “global” (whole) before “local” (detailed) features, whereas individuals with autism spectrum disorder (ASD) exhibit a local bias. However, auditory global–local distinctions are less clear in ASD, particularly in terms of age and attention effects. To these aims, here ASD and TD children judged local and global pitch structure in nine-tone melodies. Both groups showed a similar global precedence effect, but ASD children were less sensitive to global interference than TD children at younger ages. There was no effect of attention task. These findings provide novel evidence of developmental differences in auditory perception and may help to refine sensory phenotypes in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2684-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284 Effects of age and symptomatology on cortical thickness in autism spectrum disorders / Krissy A. R. DOYLE-THOMAS in Research in Autism Spectrum Disorders, 7-1 (January 2013)
[article]
Titre : Effects of age and symptomatology on cortical thickness in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Krissy A. R. DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur Année de publication : 2013 Article en page(s) : p.141-50 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Structural MRI Cortical thickness Social impairment Developmental changes Index. décimale : PER Périodiques Résumé : Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179
in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50[article] Effects of age and symptomatology on cortical thickness in autism spectrum disorders [Texte imprimé et/ou numérique] / Krissy A. R. DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2013 . - p.141-50.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50
Mots-clés : Autism spectrum disorders Structural MRI Cortical thickness Social impairment Developmental changes Index. décimale : PER Périodiques Résumé : Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 Erratum to: Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review / Azadeh KUSHKI in Journal of Autism and Developmental Disorders, 41-12 (December 2011)
PermalinkExamining the effect of a wearable, anxiety detection technology on improving the awareness of anxiety signs in autism spectrum disorder: a pilot randomized controlled trial / J. NGUYEN in Molecular Autism, 12 (2021)
PermalinkExploring sensory phenotypes in autism spectrum disorder / N. E. SCHEERER in Molecular Autism, 12 (2021)
PermalinkExploring the association between social skills struggles and social communication difficulties and depression in youth with autism spectrum disorder / Kaitlyn FORBES ; Laura DE LA ROCHE ; Brianne DERBY ; Elaine PSARADELLIS ; Evdokia ANAGNOSTOU ; Rob NICOLSON ; Stelios GEORGIADES ; Elizabeth KELLEY in Autism Research, 16-11 (November 2023)
PermalinkExploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders / Victoria HALLETT in Journal of Autism and Developmental Disorders, 43-10 (October 2013)
PermalinkExploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder / Leticia RIBEIRO DE OLIVEIRA in Research in Autism Spectrum Disorders, 73 (May 2019)
PermalinkFactor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder / N. J. BRIERLEY in Journal of Autism and Developmental Disorders, 51-10 (October 2021)
PermalinkFunctional autonomic nervous system profile in children with autism spectrum disorder / Azadeh KUSHKI in Molecular Autism, (July 2014)
PermalinkFuture directions / Jessica BRIAN
PermalinkFuture Directions in the Treatment of Autism Spectrum Disorders / Evdokia ANAGNOSTOU
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