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Auteur John N. CONSTANTINO |
Documents disponibles écrits par cet auteur (42)
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New guidance to seekers of autism biomarkers: an update from studies of identical twins / John N. CONSTANTINO in Molecular Autism, 12 (2021)
[article]
Titre : New guidance to seekers of autism biomarkers: an update from studies of identical twins Type de document : Texte imprimé et/ou numérique Auteurs : John N. CONSTANTINO, Auteur Article en page(s) : 28 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: The autism spectrum disorders (ASD) are common neuropsychiatric conditions of childhood for which the vast proportion of population risk is attributable to inheritance, and for which there exist few if any replicated biomarkers. MAIN BODY: This commentary summarizes a set of recent studies involving identical (monozygotic, MZ) twins which, taken together, have significant implications for the search for biomarkers of inherited susceptibility to autism. A first is that variation-in-severity of the condition (above the threshold for clinical diagnosis) appears more strongly influenced by stochastic/non-shared environmental influences than by heredity. Second is that there exist disparate early behavioral predictors of the familial recurrence of autism, which are themselves strongly genetically influenced but largely independent from one another. The nature of these postnatal predictors is that they are trait-like, continuously distributed in the general population, and largely independent from variation in general cognition, thereby reflecting a developmental substructure for familial autism. A corollary of these findings is that autism may arise as a developmental consequence of an allostatic load of earlier-occurring liabilities, indexed by early behavioral endophenotypes, in varying permutations and combinations. The clinical threshold can be viewed as a "tipping point" at which stochastic influences and/or other non-shared environmental influences assert much stronger influence on variation-in-severity (a) than do the genetic factors which contributed to the condition in the first place, and (b) than is observed in typical development. CONCLUSION: Biomarkers identified on the basis of association with clinical symptom severity in ASD may reflect effects rather than causes of autism. The search for biomarkers of pathogenesis may benefit from a greater focus on traits that predict autism recurrence, among both clinical and general populations. In case-control studies, salient developmental liabilities should be systematically measured in both cases and controls, to avoid the erosion in statistical power (i.e., to detect differences) that can occur if control subjects carry sub-clinical aggregations of the same unmeasured traits that exert causal influences on the development of autism. En ligne : http://dx.doi.org/10.1186/s13229-021-00434-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 28 p.[article] New guidance to seekers of autism biomarkers: an update from studies of identical twins [Texte imprimé et/ou numérique] / John N. CONSTANTINO, Auteur . - 28 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 28 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND: The autism spectrum disorders (ASD) are common neuropsychiatric conditions of childhood for which the vast proportion of population risk is attributable to inheritance, and for which there exist few if any replicated biomarkers. MAIN BODY: This commentary summarizes a set of recent studies involving identical (monozygotic, MZ) twins which, taken together, have significant implications for the search for biomarkers of inherited susceptibility to autism. A first is that variation-in-severity of the condition (above the threshold for clinical diagnosis) appears more strongly influenced by stochastic/non-shared environmental influences than by heredity. Second is that there exist disparate early behavioral predictors of the familial recurrence of autism, which are themselves strongly genetically influenced but largely independent from one another. The nature of these postnatal predictors is that they are trait-like, continuously distributed in the general population, and largely independent from variation in general cognition, thereby reflecting a developmental substructure for familial autism. A corollary of these findings is that autism may arise as a developmental consequence of an allostatic load of earlier-occurring liabilities, indexed by early behavioral endophenotypes, in varying permutations and combinations. The clinical threshold can be viewed as a "tipping point" at which stochastic influences and/or other non-shared environmental influences assert much stronger influence on variation-in-severity (a) than do the genetic factors which contributed to the condition in the first place, and (b) than is observed in typical development. CONCLUSION: Biomarkers identified on the basis of association with clinical symptom severity in ASD may reflect effects rather than causes of autism. The search for biomarkers of pathogenesis may benefit from a greater focus on traits that predict autism recurrence, among both clinical and general populations. In case-control studies, salient developmental liabilities should be systematically measured in both cases and controls, to avoid the erosion in statistical power (i.e., to detect differences) that can occur if control subjects carry sub-clinical aggregations of the same unmeasured traits that exert causal influences on the development of autism. En ligne : http://dx.doi.org/10.1186/s13229-021-00434-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families / Thomas W. FRAZIER in Molecular Autism, (October 2015)
[article]
Titre : Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Eric A. YOUNGSTROM, Auteur ; Antonio Y. HARDAN, Auteur ; Stelios GEORGIADES, Auteur ; John N. CONSTANTINO, Auteur ; Charis ENG, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous studies have demonstrated aggregation of autistic traits in undiagnosed family members of children with autism spectrum disorder (ASD), which has significant implications for ASD risk in their offspring. This study capitalizes upon a large, quantitatively characterized clinical-epidemiologic family sample to establish the extent to which family transmission pattern and sex modulate ASD trait aggregation. En ligne : http://dx.doi.org/10.1186/s13229-015-0050-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (October 2015) . - p.1-12[article] Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Eric A. YOUNGSTROM, Auteur ; Antonio Y. HARDAN, Auteur ; Stelios GEORGIADES, Auteur ; John N. CONSTANTINO, Auteur ; Charis ENG, Auteur . - p.1-12.
Langues : Anglais (eng)
in Molecular Autism > (October 2015) . - p.1-12
Index. décimale : PER Périodiques Résumé : Previous studies have demonstrated aggregation of autistic traits in undiagnosed family members of children with autism spectrum disorder (ASD), which has significant implications for ASD risk in their offspring. This study capitalizes upon a large, quantitatively characterized clinical-epidemiologic family sample to establish the extent to which family transmission pattern and sex modulate ASD trait aggregation. En ligne : http://dx.doi.org/10.1186/s13229-015-0050-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families / J. PAGE in Molecular Autism, 7 (2016)
[article]
Titre : Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families Type de document : Texte imprimé et/ou numérique Auteurs : J. PAGE, Auteur ; John N. CONSTANTINO, Auteur ; K. ZAMBRANA, Auteur ; E. MARTIN, Auteur ; I. TUNC, Auteur ; Y. ZHANG, Auteur ; Anna ABBACCHI, Auteur ; D. MESSINGER, Auteur Article en page(s) : 39p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Child Child, Preschool Female Genetic Predisposition to Disease Hispanic Americans/genetics Humans Male Parents Phenotype Siblings Ancestry Assortative mating Hispanic Measurement Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies have indicated that quantitative autistic traits (QATs) of parents reflect inherited liabilities that may index background genetic risk for clinical autism spectrum disorder (ASD) in their offspring. Moreover, preferential mating for QATs has been observed as a potential factor in concentrating autistic liabilities in some families across generations. Heretofore, intergenerational studies of QATs have focused almost exclusively on Caucasian populations-the present study explored these phenomena in a well-characterized Hispanic population. METHODS: The present study examined QAT scores in siblings and parents of 83 Hispanic probands meeting research diagnostic criteria for ASD, and 64 non-ASD controls, using the Social Responsiveness Scale-2 (SRS-2). Ancestry of the probands was characterized by genotype, using information from 541,929 single nucleotide polymorphic markers. RESULTS: In families of Hispanic children with an ASD diagnosis, the pattern of quantitative trait correlations observed between ASD-affected children and their first-degree relatives (ICCs on the order of 0.20), between unaffected first-degree relatives in ASD-affected families (sibling/mother ICC = 0.36; sibling/father ICC = 0.53), and between spouses (mother/father ICC = 0.48) were in keeping with the influence of transmitted background genetic risk and strong preferential mating for variation in quantitative autistic trait burden. Results from analysis of ancestry-informative genetic markers among probands in this sample were consistent with that from other Hispanic populations. CONCLUSIONS: Quantitative autistic traits represent measurable indices of inherited liability to ASD in Hispanic families. The accumulation of autistic traits occurs within generations, between spouses, and across generations, among Hispanic families affected by ASD. The occurrence of preferential mating for QATs-the magnitude of which may vary across cultures-constitutes a mechanism by which background genetic liability for ASD can accumulate in a given family in successive generations. En ligne : http://dx.doi.org/10.1186/s13229-016-0100-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 39p.[article] Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families [Texte imprimé et/ou numérique] / J. PAGE, Auteur ; John N. CONSTANTINO, Auteur ; K. ZAMBRANA, Auteur ; E. MARTIN, Auteur ; I. TUNC, Auteur ; Y. ZHANG, Auteur ; Anna ABBACCHI, Auteur ; D. MESSINGER, Auteur . - 39p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 39p.
Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Child Child, Preschool Female Genetic Predisposition to Disease Hispanic Americans/genetics Humans Male Parents Phenotype Siblings Ancestry Assortative mating Hispanic Measurement Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies have indicated that quantitative autistic traits (QATs) of parents reflect inherited liabilities that may index background genetic risk for clinical autism spectrum disorder (ASD) in their offspring. Moreover, preferential mating for QATs has been observed as a potential factor in concentrating autistic liabilities in some families across generations. Heretofore, intergenerational studies of QATs have focused almost exclusively on Caucasian populations-the present study explored these phenomena in a well-characterized Hispanic population. METHODS: The present study examined QAT scores in siblings and parents of 83 Hispanic probands meeting research diagnostic criteria for ASD, and 64 non-ASD controls, using the Social Responsiveness Scale-2 (SRS-2). Ancestry of the probands was characterized by genotype, using information from 541,929 single nucleotide polymorphic markers. RESULTS: In families of Hispanic children with an ASD diagnosis, the pattern of quantitative trait correlations observed between ASD-affected children and their first-degree relatives (ICCs on the order of 0.20), between unaffected first-degree relatives in ASD-affected families (sibling/mother ICC = 0.36; sibling/father ICC = 0.53), and between spouses (mother/father ICC = 0.48) were in keeping with the influence of transmitted background genetic risk and strong preferential mating for variation in quantitative autistic trait burden. Results from analysis of ancestry-informative genetic markers among probands in this sample were consistent with that from other Hispanic populations. CONCLUSIONS: Quantitative autistic traits represent measurable indices of inherited liability to ASD in Hispanic families. The accumulation of autistic traits occurs within generations, between spouses, and across generations, among Hispanic families affected by ASD. The occurrence of preferential mating for QATs-the magnitude of which may vary across cultures-constitutes a mechanism by which background genetic liability for ASD can accumulate in a given family in successive generations. En ligne : http://dx.doi.org/10.1186/s13229-016-0100-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study / Natasha MARRUS in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)
[article]
Titre : Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study Type de document : Texte imprimé et/ou numérique Auteurs : Natasha MARRUS, Auteur ; Anne L. GLOWINSKI, Auteur ; Theodore JACOB, Auteur ; Ami KLIN, Auteur ; Warren JONES, Auteur ; Caroline E. DRAIN, Auteur ; Kieran E. HOLZHAUER, Auteur ; Vaishnavi HARIPRASAD, Auteur ; Robert T. FITZGERALD, Auteur ; Erika L. MORTENSON, Auteur ; Sayli M. SANT, Auteur ; Lyndsey COLE, Auteur ; Satchel A. SIEGEL, Auteur ; Yi ZHANG, Auteur ; Arpana AGRAWAL, Auteur ; Andrew C. HEATH, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.1338-1346 Langues : Anglais (eng) Mots-clés : Autism reciprocal social behavior video twins toddlers Index. décimale : PER Périodiques Résumé : Background Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories and incremental responses to intervention. Methods We developed and validated a 20-min video-referenced rating scale, the video-referenced rating of reciprocal social behavior (vrRSB), for untrained caregivers to provide standardized ratings of quantitative variation in RSB. Parents of 252 toddler twins [Monozygotic (MZ) = 31 pairs, Dizygotic (DZ) = 95 pairs] ascertained through birth records, rated their twins’ RSB at two time points, on average 6 months apart, and completed two developmental measures, the Modified Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s). Results Scores on the vrRSB were fully continuously distributed, with excellent 6-month test–retest reliability ([intraclass correlation coefficient] ICC = 0.704, p < .000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC = 0.863, p < .000, DZ ICC = 0.231, p < .012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t = ?8.588, df = 31, p < .000), incrementally improved from 18–24 months, and were inversely correlated with receptive and expressive vocabulary on the MCDI-s. Conclusions Like quantitative autistic trait ratings in school-aged children and adults, toddler scores on the vrRSB are continuously distributed and appear highly heritable. These ratings exhibited minimal measurement error, high inter-individual stability, and developmental progression in RSB as children matured from 18–24 months, supporting their potential utility for serially quantifying the severity of early autistic syndromes over time and in response to intervention. In addition, these findings inform the genetic-environmental structure of RSB in early typical development. En ligne : http://dx.doi.org/10.1111/jcpp.12391 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273
in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1338-1346[article] Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study [Texte imprimé et/ou numérique] / Natasha MARRUS, Auteur ; Anne L. GLOWINSKI, Auteur ; Theodore JACOB, Auteur ; Ami KLIN, Auteur ; Warren JONES, Auteur ; Caroline E. DRAIN, Auteur ; Kieran E. HOLZHAUER, Auteur ; Vaishnavi HARIPRASAD, Auteur ; Robert T. FITZGERALD, Auteur ; Erika L. MORTENSON, Auteur ; Sayli M. SANT, Auteur ; Lyndsey COLE, Auteur ; Satchel A. SIEGEL, Auteur ; Yi ZHANG, Auteur ; Arpana AGRAWAL, Auteur ; Andrew C. HEATH, Auteur ; John N. CONSTANTINO, Auteur . - p.1338-1346.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1338-1346
Mots-clés : Autism reciprocal social behavior video twins toddlers Index. décimale : PER Périodiques Résumé : Background Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories and incremental responses to intervention. Methods We developed and validated a 20-min video-referenced rating scale, the video-referenced rating of reciprocal social behavior (vrRSB), for untrained caregivers to provide standardized ratings of quantitative variation in RSB. Parents of 252 toddler twins [Monozygotic (MZ) = 31 pairs, Dizygotic (DZ) = 95 pairs] ascertained through birth records, rated their twins’ RSB at two time points, on average 6 months apart, and completed two developmental measures, the Modified Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s). Results Scores on the vrRSB were fully continuously distributed, with excellent 6-month test–retest reliability ([intraclass correlation coefficient] ICC = 0.704, p < .000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC = 0.863, p < .000, DZ ICC = 0.231, p < .012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t = ?8.588, df = 31, p < .000), incrementally improved from 18–24 months, and were inversely correlated with receptive and expressive vocabulary on the MCDI-s. Conclusions Like quantitative autistic trait ratings in school-aged children and adults, toddler scores on the vrRSB are continuously distributed and appear highly heritable. These ratings exhibited minimal measurement error, high inter-individual stability, and developmental progression in RSB as children matured from 18–24 months, supporting their potential utility for serially quantifying the severity of early autistic syndromes over time and in response to intervention. In addition, these findings inform the genetic-environmental structure of RSB in early typical development. En ligne : http://dx.doi.org/10.1111/jcpp.12391 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis / M. MICHELETTI in Journal of Child Psychology and Psychiatry, 61-1 (January 2020)
[article]
Titre : Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : M. MICHELETTI, Auteur ; C. MCCRACKEN, Auteur ; John N. CONSTANTINO, Auteur ; D. MANDELL, Auteur ; W. JONES, Auteur ; A. KLIN, Auteur Article en page(s) : p.4-17 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder meta-analysis outcomes sampling bias surveillance systematic review toddlers Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite widespread recommendations for early surveillance of risk for autism spectrum disorder (ASD), no research to date has shown that early surveillance leads to better clinical outcomes. Preliminary research has suggested that children with ASD ascertained via prospective follow-up have better outcomes than those ascertained via community referral. Because prospective studies include early surveillance, by comparing outcomes of children with ASD across ascertainment strategies, we may gain insight into the effects of early surveillance relative to its absence. METHODS: A systematic review was conducted to identify studies reporting outcomes of 24- to 36-month-olds with ASD ascertained via prospective follow-up, community referral, or universal screening. A meta-analysis using a random effects model was used to calculate overall effect size estimates for developmental level and symptom severity across ascertainment cohorts. RESULTS: Eleven prospective, ten community referral, and eight universal screening studies were identified, reporting on 1,658 toddlers with ASD. We found no differences in outcomes between community referral and universal screening studies. Relative to both, prospective studies reported significantly higher developmental levels and lower symptom severities. CONCLUSIONS: Outcomes of young children with ASD ascertained via prospective follow-up are better than those of children with ASD recruited via community referral or universal screening. Although we discuss why sampling bias is not likely the driving force behind these findings, we cannot rule out the possibility that sampling bias contributes to the observed differences; future studies should probe the effects of sociodemographic variables on clinical outcomes as a function of ascertainment strategy. This limitation notwithstanding, our results raise the possibility that prospective follow-up may confer a 'surveillance effect' that contributes to improved developmental and diagnostic outcomes in children with ASD. Future research should test this hypothesis and determine the specific mechanism by which surveillance may improve outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.13057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413
in Journal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.4-17[article] Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis [Texte imprimé et/ou numérique] / M. MICHELETTI, Auteur ; C. MCCRACKEN, Auteur ; John N. CONSTANTINO, Auteur ; D. MANDELL, Auteur ; W. JONES, Auteur ; A. KLIN, Auteur . - p.4-17.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.4-17
Mots-clés : Autism spectrum disorder meta-analysis outcomes sampling bias surveillance systematic review toddlers Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite widespread recommendations for early surveillance of risk for autism spectrum disorder (ASD), no research to date has shown that early surveillance leads to better clinical outcomes. Preliminary research has suggested that children with ASD ascertained via prospective follow-up have better outcomes than those ascertained via community referral. Because prospective studies include early surveillance, by comparing outcomes of children with ASD across ascertainment strategies, we may gain insight into the effects of early surveillance relative to its absence. METHODS: A systematic review was conducted to identify studies reporting outcomes of 24- to 36-month-olds with ASD ascertained via prospective follow-up, community referral, or universal screening. A meta-analysis using a random effects model was used to calculate overall effect size estimates for developmental level and symptom severity across ascertainment cohorts. RESULTS: Eleven prospective, ten community referral, and eight universal screening studies were identified, reporting on 1,658 toddlers with ASD. We found no differences in outcomes between community referral and universal screening studies. Relative to both, prospective studies reported significantly higher developmental levels and lower symptom severities. CONCLUSIONS: Outcomes of young children with ASD ascertained via prospective follow-up are better than those of children with ASD recruited via community referral or universal screening. Although we discuss why sampling bias is not likely the driving force behind these findings, we cannot rule out the possibility that sampling bias contributes to the observed differences; future studies should probe the effects of sociodemographic variables on clinical outcomes as a function of ascertainment strategy. This limitation notwithstanding, our results raise the possibility that prospective follow-up may confer a 'surveillance effect' that contributes to improved developmental and diagnostic outcomes in children with ASD. Future research should test this hypothesis and determine the specific mechanism by which surveillance may improve outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.13057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 Response to "A Radical Change in Our Autism Research Strategy is Needed: Back to Prototypes" by Mottron et al. (2021) / John N. CONSTANTINO in Autism Research, 14-10 (October 2021)
PermalinkSensory Responsiveness in Siblings of Children with Autism Spectrum Disorders / Claudia L. HILTON in Journal of Autism and Developmental Disorders, 46-12 (December 2016)
PermalinkSex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority / Alycia K. HALLADAY in Molecular Autism, (June 2015)
PermalinkSocial and Non-Social Cueing of Visuospatial Attention in Autism and Typical Development / John R. PRUETT in Journal of Autism and Developmental Disorders, 41-6 (June 2011)
PermalinkSocial motivation in infancy is associated with familial recurrence of ASD / Natasha MARRUS in Development and Psychopathology, 36-1 (February 2024)
PermalinkSocial Responsiveness Scale, Second Edition (SRS-2) / John N. CONSTANTINO
PermalinkSRS-2 : Echelle de réciprocité sociale / John N. CONSTANTINO
PermalinkSymptoms of autism spectrum disorder and anxiety: shared familial transmission and cross-assortative mating / Jorieke DUVEKOT in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)
PermalinkTaking stock of critical clues to understanding sex differences in the prevalence and recurrence of autism / John N. CONSTANTINO in Autism, 21-6 (August 2017)
PermalinkThe female protective effect in autism spectrum disorder is not mediated by a single genetic locus / Jake GOCKLEY in Molecular Autism, (May 2015)
PermalinkThe social responsiveness scale in relation to DSM IV and DSM5 ASD in Korean children / Keun-Ah CHEON in Autism Research, 9-9 (September 2016)
PermalinkA video-based measure to identify autism risk in infancy / Gregory S. YOUNG in Journal of Child Psychology and Psychiatry, 61-1 (January 2020)
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