Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder / Ghizlane GAOUGAOU in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder Type de document : texte imprimé Auteurs : Ghizlane GAOUGAOU, Auteur ; Riham ZAHRA, Auteur ; Sophia MOREL, Auteur ; Véronique BÉLANGER, Auteur ; Inga Sophia KNOTH, Auteur ; Dominique COUSINEAU, Auteur ; Baudouin Forgeot D'ARC, Auteur ; Kelly GRZYWACZ, Auteur ; Guy ROUSSEAU, Auteur ; Eric DÉZIEL, Auteur ; Roger GODBOUT, Auteur ; Sarah LIPPE, Auteur ; Mathieu MILLETTE, Auteur ; Valérie MARCIL, Auteur Langues : Anglais (eng) Mots-clés : Humans  Autism Spectrum Disorder/diet therapy/complications  Probiotics/administration & dosage/adverse effects/therapeutic use  Male  Child  Female  Child, Preschool  Feasibility Studies  Gastrointestinal Diseases  Sleep Wake Disorders  Dietary Supplements  Beverages  Patient Acceptance of Health Care  Acceptability  Autism spectrum disorders  Autistic symptoms  Children  Feasibility  Gastrointestinal symptoms  Probiotics  Safety  Sleep disorder  by the ethics review board of the CHU Sainte-Justine (#2021–3412). Informed  consent was obtained from all participants and parents involved in the study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication and social interaction. ASD is associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms and sleep disorders. Evidence supports an association between intestinal dysbiosis and the severity of ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis and decrease neurobehavioral, GI and sleep symptoms in individuals diagnosed with autism. METHODS: This study aims to evaluate the acceptability and safety of a Bio-K + probiotics beverage in autistic children aged 4 to 11 years and the feasibility of the proposed research protocol to measure its impact on behaviors and comorbidities. The 30-week study consisted of daily supplementation with Bio-K + probiotics for 14 weeks. Acceptability and safety were monitored throughout the study. Feasibility was assessed by comparing recruitment and completion rates to pre-established thresholds. Preliminary impact of supplementation on behaviors (Autism Treatment Evaluation Checklist (ATEC) score), GI symptoms and sleep disorders was evaluated. RESULTS: Of the 23 children recruited (mean age 6.7 ± 2.2 years, 70% males), 65% had GI problems and 91% had sleep disorders. Probiotic supplementation was accepted by all participants and no product-related adverse event was reported. Feasibility rates exceeded pre-established thresholds for almost all study outcomes including recruitment rate, compliance, electroencephalography, actigraphy and completion of questionnaires. Preliminary data suggest an improvement in behaviors associated with autism assessed with the total ATEC score, and in GI symptoms and sleep disorders. CONCLUSION: This study demonstrates probiotic beverage acceptability and safety and protocol feasibility in autistic children. To further support our data, a double-blinded placebo-controlled study is needed to determine its efficacy. En ligne : https://dx.doi.org/10.1186/s11689-025-09617-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder [texte imprimé] / Ghizlane GAOUGAOU, Auteur ; Riham ZAHRA, Auteur ; Sophia MOREL, Auteur ; Véronique BÉLANGER, Auteur ; Inga Sophia KNOTH, Auteur ; Dominique COUSINEAU, Auteur ; Baudouin Forgeot D'ARC, Auteur ; Kelly GRZYWACZ, Auteur ; Guy ROUSSEAU, Auteur ; Eric DÉZIEL, Auteur ; Roger GODBOUT, Auteur ; Sarah LIPPE, Auteur ; Mathieu MILLETTE, Auteur ; Valérie MARCIL, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Autism Spectrum Disorder/diet therapy/complications  Probiotics/administration & dosage/adverse effects/therapeutic use  Male  Child  Female  Child, Preschool  Feasibility Studies  Gastrointestinal Diseases  Sleep Wake Disorders  Dietary Supplements  Beverages  Patient Acceptance of Health Care  Acceptability  Autism spectrum disorders  Autistic symptoms  Children  Feasibility  Gastrointestinal symptoms  Probiotics  Safety  Sleep disorder  by the ethics review board of the CHU Sainte-Justine (#2021–3412). Informed  consent was obtained from all participants and parents involved in the study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication and social interaction. ASD is associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms and sleep disorders. Evidence supports an association between intestinal dysbiosis and the severity of ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis and decrease neurobehavioral, GI and sleep symptoms in individuals diagnosed with autism. METHODS: This study aims to evaluate the acceptability and safety of a Bio-K + probiotics beverage in autistic children aged 4 to 11 years and the feasibility of the proposed research protocol to measure its impact on behaviors and comorbidities. The 30-week study consisted of daily supplementation with Bio-K + probiotics for 14 weeks. Acceptability and safety were monitored throughout the study. Feasibility was assessed by comparing recruitment and completion rates to pre-established thresholds. Preliminary impact of supplementation on behaviors (Autism Treatment Evaluation Checklist (ATEC) score), GI symptoms and sleep disorders was evaluated. RESULTS: Of the 23 children recruited (mean age 6.7 ± 2.2 years, 70% males), 65% had GI problems and 91% had sleep disorders. Probiotic supplementation was accepted by all participants and no product-related adverse event was reported. Feasibility rates exceeded pre-established thresholds for almost all study outcomes including recruitment rate, compliance, electroencephalography, actigraphy and completion of questionnaires. Preliminary data suggest an improvement in behaviors associated with autism assessed with the total ATEC score, and in GI symptoms and sleep disorders. CONCLUSION: This study demonstrates probiotic beverage acceptability and safety and protocol feasibility in autistic children. To further support our data, a double-blinded placebo-controlled study is needed to determine its efficacy. En ligne : https://dx.doi.org/10.1186/s11689-025-09617-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health / Kerri WHITLOCK ; Cory ROSENFELT ; Julie SHATTO ; Brittany FINLAY ; Jennifer ZWICKER ; Sarah LIPPE ; Sébastien JACQUEMONT ; Randi J. HAGERMAN ; Kara MURIAS ; Francois V. BOLDUC in Journal of Autism and Developmental Disorders, 55-5 (May 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1910-1922 Titre : Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health Type de document : texte imprimé Auteurs : Kerri WHITLOCK, Auteur ; Cory ROSENFELT, Auteur ; Julie SHATTO, Auteur ; Brittany FINLAY, Auteur ; Jennifer ZWICKER, Auteur ; Sarah LIPPE, Auteur ; Sébastien JACQUEMONT, Auteur ; Randi J. HAGERMAN, Auteur ; Kara MURIAS, Auteur ; Francois V. BOLDUC, Auteur Article en page(s) : p.1910-1922 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The purpose of this paper was to examine the physical, emotional, social and school functioning domains of quality of life of individuals with Fragile X Syndrome, in relation to mental health and sleep patterns to gain a better understanding of how these aspects are affected by the disorder. This study included 119 individuals with Fragile X Syndrome who were given different cognitive examinations by a neuropsychologist or by parent-proxy questionnaires. This study focused on the Pediatric Quality of Life Inventory (PedsQoL), the Anxiety, Depression and Mood Scale (ADAMS), the Children s Sleep Habits Questionnaire (CSHQ), but did include other cognitive tests (Vineland Adaptive Behaviour Scales, Nonverbal IQ, Autism Diagnostic Observation Schedule). We identified significant associations between decreases in emotional, social and school domains of PedsQoL and the ADAMS subtests of Generalized Anxiety, Manic/Hyperactivity and Obsessive/Compulsivity, with the subtest of Depressed Mood having associations with lower physical and emotional domains. We also identified a significant impact between CSHQ subtests of Sleep Anxiety, Night Wakings, Daytime Sleepiness, and Parasomnia with the emotional and school domains of PedsQoL. There were associations connecting school functioning with Bedtime Resistance, and additional associations connecting emotional functioning with Sleep Duration and Sleep Onset Delay. Physical functioning was also associated with Sleep Anxiety. Our study shows how mental health and sleep defects impact improper sleep patterns and mental health which leads to decreases in the quality of life for individuals with FXS, and how it is important to screen for these symptoms in order to alleviate issues. En ligne : https://doi.org/10.1007/s10803-024-06317-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health [texte imprimé] / Kerri WHITLOCK, Auteur ; Cory ROSENFELT, Auteur ; Julie SHATTO, Auteur ; Brittany FINLAY, Auteur ; Jennifer ZWICKER, Auteur ; Sarah LIPPE, Auteur ; Sébastien JACQUEMONT, Auteur ; Randi J. HAGERMAN, Auteur ; Kara MURIAS, Auteur ; Francois V. BOLDUC, Auteur . - p.1910-1922. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1910-1922 Index. décimale : PER Périodiques Résumé : The purpose of this paper was to examine the physical, emotional, social and school functioning domains of quality of life of individuals with Fragile X Syndrome, in relation to mental health and sleep patterns to gain a better understanding of how these aspects are affected by the disorder. This study included 119 individuals with Fragile X Syndrome who were given different cognitive examinations by a neuropsychologist or by parent-proxy questionnaires. This study focused on the Pediatric Quality of Life Inventory (PedsQoL), the Anxiety, Depression and Mood Scale (ADAMS), the Children s Sleep Habits Questionnaire (CSHQ), but did include other cognitive tests (Vineland Adaptive Behaviour Scales, Nonverbal IQ, Autism Diagnostic Observation Schedule). We identified significant associations between decreases in emotional, social and school domains of PedsQoL and the ADAMS subtests of Generalized Anxiety, Manic/Hyperactivity and Obsessive/Compulsivity, with the subtest of Depressed Mood having associations with lower physical and emotional domains. We also identified a significant impact between CSHQ subtests of Sleep Anxiety, Night Wakings, Daytime Sleepiness, and Parasomnia with the emotional and school domains of PedsQoL. There were associations connecting school functioning with Bedtime Resistance, and additional associations connecting emotional functioning with Sleep Duration and Sleep Onset Delay. Physical functioning was also associated with Sleep Anxiety. Our study shows how mental health and sleep defects impact improper sleep patterns and mental health which leads to decreases in the quality of life for individuals with FXS, and how it is important to screen for these symptoms in order to alleviate issues. En ligne : https://doi.org/10.1007/s10803-024-06317-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome / Mélodie PROTEAU-LEMIEUX in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70194 Titre : Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome Type de document : texte imprimé Auteurs : Mélodie PROTEAU-LEMIEUX, Auteur ; Inga S. KNOTH, Auteur ; Saeideh DAVOUDI, Auteur ; Rae BUCKSER, Auteur ; Charles-Olivier MARTIN, Auteur ; Anne-Marie BÉLANGER, Auteur ; Valérie K. FONTAINE, Auteur ; Hazel Maridith Barlahan BIAG, Auteur ; Leonard ABBEDUTO, Auteur ; Sébastien JACQUEMONT, Auteur ; David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Andrea SCHNEIDER, Auteur ; Francois V. BOLDUC, Auteur ; Sarah LIPPE, Auteur Article en page(s) : e70194 Langues : Anglais (eng) Mots-clés : behavior  cognition  EEG  fragile X syndrome  PSD  resting state  signal complexity Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X Syndrome (FXS), an X-linked genetic condition, is associated with a wide range of phenotypic manifestations, namely intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and atypical behaviors. Individuals with FXS present robust electrophysiological (EEG) alterations, notably on signal complexity and power spectral density (PSD) resting state measures. To which extent they are associated to specific behavioral phenotypes in the FXS population remains to be comprehensively addressed. This study aimed to investigate the relations between resting state EEG markers and the most frequently observed symptoms in FXS. EEG and behavioral data from 41 individuals with FXS aged between 7 and 34?years old were collected, and correlational approaches were used to analyze the associations between EEG markers and symptomatology. We observed positive associations between complexity in higher scales and non-verbal intelligence quotient (NVIQ). Reduced alpha power, a robust biomarker in FXS, was associated with more social avoidance, a hallmark in FXS. Decreased high gamma power was linked to hyperactive symptoms. Our results suggest powerful relations between known biomarkers and core symptoms in FXS, highlighting that EEG biomarkers correspond to symptom severity which further supports their potential as objective, translational treatment outcome measures. En ligne : https://doi.org/10.1002/aur.70194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome [texte imprimé] / Mélodie PROTEAU-LEMIEUX, Auteur ; Inga S. KNOTH, Auteur ; Saeideh DAVOUDI, Auteur ; Rae BUCKSER, Auteur ; Charles-Olivier MARTIN, Auteur ; Anne-Marie BÉLANGER, Auteur ; Valérie K. FONTAINE, Auteur ; Hazel Maridith Barlahan BIAG, Auteur ; Leonard ABBEDUTO, Auteur ; Sébastien JACQUEMONT, Auteur ; David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Andrea SCHNEIDER, Auteur ; Francois V. BOLDUC, Auteur ; Sarah LIPPE, Auteur . - e70194. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70194 Mots-clés : behavior  cognition  EEG  fragile X syndrome  PSD  resting state  signal complexity Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X Syndrome (FXS), an X-linked genetic condition, is associated with a wide range of phenotypic manifestations, namely intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and atypical behaviors. Individuals with FXS present robust electrophysiological (EEG) alterations, notably on signal complexity and power spectral density (PSD) resting state measures. To which extent they are associated to specific behavioral phenotypes in the FXS population remains to be comprehensively addressed. This study aimed to investigate the relations between resting state EEG markers and the most frequently observed symptoms in FXS. EEG and behavioral data from 41 individuals with FXS aged between 7 and 34?years old were collected, and correlational approaches were used to analyze the associations between EEG markers and symptomatology. We observed positive associations between complexity in higher scales and non-verbal intelligence quotient (NVIQ). Reduced alpha power, a robust biomarker in FXS, was associated with more social avoidance, a hallmark in FXS. Decreased high gamma power was linked to hyperactive symptoms. Our results suggest powerful relations between known biomarkers and core symptoms in FXS, highlighting that EEG biomarkers correspond to symptom severity which further supports their potential as objective, translational treatment outcome measures. En ligne : https://doi.org/10.1002/aur.70194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

L'évaluation psychologique ou neuropsychologique du TDAH / Sarah LIPPE

Public ISBD in Le trouble de déficit de l'attention avec ou sans hyperactivité / Stacey BELANGER Titre : L'évaluation psychologique ou neuropsychologique du TDAH Type de document : texte imprimé Auteurs : Sarah LIPPE, Auteur ; Catherine-Marie VANASSE, Auteur Année de publication : 2019 Importance : p.51-74 Langues : Français (fre) Index. décimale : TRO-E TRO-E - TDA-H Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 in Le trouble de déficit de l'attention avec ou sans hyperactivité / Stacey BELANGER L'évaluation psychologique ou neuropsychologique du TDAH [texte imprimé] / Sarah LIPPE, Auteur ; Catherine-Marie VANASSE, Auteur . - 2019 . - p.51-74. Langues : Français (fre) Index. décimale : TRO-E TRO-E - TDA-H Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

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Neuropsychologie de l'enfant épileptique / Sarah LIPPE

Public ISBD contenu dans Neuropsychologie / Pierre NOLIN Titre : Neuropsychologie de l'enfant épileptique Type de document : texte imprimé Auteurs : Sarah LIPPE, Auteur ; Hannelore C. SAUERWEIN, Auteur ; Maryse LASSONDE, Auteur Année de publication : 2004 Importance : p.137-162 Langues : Français (fre) Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=760 contenu dans Neuropsychologie / Pierre NOLIN Neuropsychologie de l'enfant épileptique [texte imprimé] / Sarah LIPPE, Auteur ; Hannelore C. SAUERWEIN, Auteur ; Maryse LASSONDE, Auteur . - 2004 . - p.137-162. Langues : Français (fre) Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=760

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Specific EEG resting state biomarkers in FXS and ASD / Mélodie PROTEAU-LEMIEUX in Journal of Neurodevelopmental Disorders, 16 (2024)  

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Steady-state visual evoked potentials in children with neurofibromatosis type 1: associations with behavioral rating scales and impact of psychostimulant medication / Eve LALANCETTE in Journal of Neurodevelopmental Disorders, 14 (2022)  

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Le trouble du déficit de l'attention avec ou sans hyperactivité / Stacey BELANGER

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