A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort / Keely CHESLACK-POSTAVA in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2444-2453 Titre : A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort Type de document : texte imprimé Auteurs : Keely CHESLACK-POSTAVA, Auteur ; Andre SOURANDER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Alan S. BROWN, Auteur Article en page(s) : p.2444-2453 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Biomarkers  Case-Control Studies  Child  Female  Finland/epidemiology  Humans  Maternal Exposure  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology  Smoking  autism  cotinine  prenatal exposure delayed effects  smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30 days), sex, and place of birth (N = 962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort [texte imprimé] / Keely CHESLACK-POSTAVA, Auteur ; Andre SOURANDER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Alan S. BROWN, Auteur . - p.2444-2453. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2444-2453 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Biomarkers  Case-Control Studies  Child  Female  Finland/epidemiology  Humans  Maternal Exposure  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology  Smoking  autism  cotinine  prenatal exposure delayed effects  smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30 days), sex, and place of birth (N = 962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort / Laura TIMONEN-SOIVIO in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2780-2784 Titre : Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort Type de document : texte imprimé Auteurs : Laura TIMONEN-SOIVIO, Auteur ; Raija VANHALA, Auteur ; Heli MALM, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur Article en page(s) : p.2780-2784 Langues : Anglais (eng) Mots-clés : Syndromic autism  Chromosomal abnormalities  Autism spectrum disorder  Single gene disorders Index. décimale : PER Périodiques Résumé : We studied the association between specific congenital syndromes and autism spectrum disorders (ASD) in the large Finnish Register material. Our data include all children diagnosed with ASD (n = 4441) according to Finnish Hospital Discharge Register in 1987–2000. Four controls per each case were matched to sex, birthplace, date of birth (±30 days) and residence in Finland (n = 17,695). The prevalence of specific congenital syndromes in the Finnish Register of Congenital Malformations was evaluated among the ASD group and the controls by sex. The results of this study suggest that there is an association between several etiologically different syndromes and ASD when compared to controls without ASD. Statistically significant associations were observed with 47,XYY, Sotos syndrome, neurofibromatosis I, and syndrome not otherwise specified. Syndromes were more common among males with ASD compared to controls. These results support the previous studies of etiological heterogeneity of ASD and have importance in clinical examination, management and rehabilitation. En ligne : http://dx.doi.org/10.1007/s10803-016-2789-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort [texte imprimé] / Laura TIMONEN-SOIVIO, Auteur ; Raija VANHALA, Auteur ; Heli MALM, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur . - p.2780-2784. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2780-2784 Mots-clés : Syndromic autism  Chromosomal abnormalities  Autism spectrum disorder  Single gene disorders Index. décimale : PER Périodiques Résumé : We studied the association between specific congenital syndromes and autism spectrum disorders (ASD) in the large Finnish Register material. Our data include all children diagnosed with ASD (n = 4441) according to Finnish Hospital Discharge Register in 1987–2000. Four controls per each case were matched to sex, birthplace, date of birth (±30 days) and residence in Finland (n = 17,695). The prevalence of specific congenital syndromes in the Finnish Register of Congenital Malformations was evaluated among the ASD group and the controls by sex. The results of this study suggest that there is an association between several etiologically different syndromes and ASD when compared to controls without ASD. Statistically significant associations were observed with 47,XYY, Sotos syndrome, neurofibromatosis I, and syndrome not otherwise specified. Syndromes were more common among males with ASD compared to controls. These results support the previous studies of etiological heterogeneity of ASD and have importance in clinical examination, management and rehabilitation. En ligne : http://dx.doi.org/10.1007/s10803-016-2789-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study / Elina JOKIRANTA in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557 Titre : Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study Type de document : texte imprimé Auteurs : Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur Article en page(s) : p.2547-2557 Langues : Anglais (eng) Mots-clés : Epilepsy  Autism spectrum disorders  Intellectual disability  Gender  Age at onset  Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 [article] Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study [texte imprimé] / Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur . - p.2547-2557. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557 Mots-clés : Epilepsy  Autism spectrum disorders  Intellectual disability  Gender  Age at onset  Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240

Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design / Katja M. LAMPI in Journal of Autism and Developmental Disorders, 41-8 (August 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1090-1096 Titre : Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design Type de document : texte imprimé Auteurs : Katja M. LAMPI, Auteur ; P. Nina BANERJEE, Auteur ; Mika GISSLER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Jukka HUTTUNEN, Auteur ; Ulla KULMALA, Auteur ; Jarna LINDROOS, Auteur ; Solja NIEMELA, Auteur ; Maria RIHKO, Auteur ; Terja RISTKARI, Auteur ; Kristiina SAANAKORPI, Auteur ; Tanja SARLIN, Auteur ; Lauri SILLANMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Hans HELENIUS, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur Année de publication : 2011 Article en page(s) : p.1090-1096 Langues : Anglais (eng) Mots-clés : Autism  Register study  Prenatal risk factors  Epidemiology  Methodology Index. décimale : PER Périodiques Résumé : This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between births from 1987 to 2005 ascertained from the Finnish Medical Birth Register (FMBR) and other national registers on treatment for this group of disorders. All subjects were members of the Finnish Maternity Cohort (FMC), which consists of virtually all births in Finland from 1983 to the present, and which includes archived maternal serum samples. This study also capitalizes on other registry information, such as systematically collected data on pregnancy, prenatal and neonatal complications and manual data collection from well-child clinics providing developmental data from birth to the age of 7 years. In this paper, we describe the methods used in the FIPS-A study, including a description of the national registers, available data and case ascertainment procedures. Finally, we discuss implications of the data for future work on uncovering putative aetiologies of ASD and key strengths and limitations of the design. En ligne : http://dx.doi.org/10.1007/s10803-010-1132-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design [texte imprimé] / Katja M. LAMPI, Auteur ; P. Nina BANERJEE, Auteur ; Mika GISSLER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Jukka HUTTUNEN, Auteur ; Ulla KULMALA, Auteur ; Jarna LINDROOS, Auteur ; Solja NIEMELA, Auteur ; Maria RIHKO, Auteur ; Terja RISTKARI, Auteur ; Kristiina SAANAKORPI, Auteur ; Tanja SARLIN, Auteur ; Lauri SILLANMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Hans HELENIUS, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur . - 2011 . - p.1090-1096. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1090-1096 Mots-clés : Autism  Register study  Prenatal risk factors  Epidemiology  Methodology Index. décimale : PER Périodiques Résumé : This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between births from 1987 to 2005 ascertained from the Finnish Medical Birth Register (FMBR) and other national registers on treatment for this group of disorders. All subjects were members of the Finnish Maternity Cohort (FMC), which consists of virtually all births in Finland from 1983 to the present, and which includes archived maternal serum samples. This study also capitalizes on other registry information, such as systematically collected data on pregnancy, prenatal and neonatal complications and manual data collection from well-child clinics providing developmental data from birth to the age of 7 years. In this paper, we describe the methods used in the FIPS-A study, including a description of the national registers, available data and case ascertainment procedures. Finally, we discuss implications of the data for future work on uncovering putative aetiologies of ASD and key strengths and limitations of the design. En ligne : http://dx.doi.org/10.1007/s10803-010-1132-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort / Katja M. LAMPI in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2526-2535 Titre : Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort Type de document : texte imprimé Auteurs : Katja M. LAMPI, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Venla LEHTI, Auteur ; Hans HELENIUS, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur Article en page(s) : p.2526-2535 Langues : Anglais (eng) Mots-clés : Epidemiology  Autism spectrum disorders  Parental age Index. décimale : PER Périodiques Résumé : Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger’s syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35–49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger’s syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1801-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort [texte imprimé] / Katja M. LAMPI, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Venla LEHTI, Auteur ; Hans HELENIUS, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur . - p.2526-2535. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2526-2535 Mots-clés : Epidemiology  Autism spectrum disorders  Parental age Index. décimale : PER Périodiques Résumé : Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger’s syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35–49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger’s syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1801-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

Prenatal toxoplasmosis antibody and childhood autism / Marisa N. SPANN in Autism Research, 10-5 (May 2017)  

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The Association Between Autism Spectrum Disorders and Congenital Anomalies by Organ Systems in a Finnish National Birth Cohort / Laura TIMONEN-SOIVIO in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

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