Access to services for autistic people across Europe / Siti Nurnadhirah BINTE MOHD IKHSAN in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 35 Titre : Access to services for autistic people across Europe Type de document : texte imprimé Auteurs : Siti Nurnadhirah BINTE MOHD IKHSAN, Auteur ; Rosemary HOLT, Auteur ; Joyce MAN, Auteur ; Tracey PARSONS, Auteur ; Rik SCHALBROECK, Auteur ; Amber RUIGROK, Auteur ; Aurélie BARANGER, Auteur ; Carrie ALLISON, Auteur ; Mary DOHERTY, Auteur ; Katrien VAN DEN BOSCH, Auteur ; Jerneja TERÄŒON, Auteur ; Pierre VIOLLAND, Auteur ; Anjuli GHOSH, Auteur ; James CUSACK, Auteur ; Simon BARON-COHEN, Auteur ; Siti Nurnadhirah BINTE MOHD IKHSAN, Auteur ; Rosemary HOLT, Auteur ; Joyce MAN, Auteur ; Tracey PARSONS, Auteur ; Rik SCHALBROECK, Auteur ; Amber RUIGROK, Auteur ; Aurélie BARANGER, Auteur ; Carrie ALLISON, Auteur ; Mary DOHERTY, Auteur ; Katrien VAN DEN BOSCH, Auteur ; Jerneja TERÄŒON, Auteur ; Pierre VIOLLAND, Auteur ; Anjuli GHOSH, Auteur ; James CUSACK, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 35 Langues : Anglais (eng) Mots-clés : Humans  Male  Health Services Accessibility/statistics & numerical data  Female  Adult  Autistic Disorder/therapy/epidemiology/diagnosis  Europe/epidemiology  Adolescent  Middle Aged  Child  Young Adult  Surveys and Questionnaires  United Kingdom  Autism  Europe  Policy  Service access  Service barriers  Services  Survey  conducted in accordance with the principles outlined in the Declaration of  Helsinki. All participants gave written informed consent in the ACCESS-EU study,  which was approved by the Cambridge Psychology Research Ethics Committee  (reference number PRE.2019.088). As this research involved an online survey, it  adhered to ethical standards for informed consent, participant confidentiality,  and data protection. All participants were provided with a clear informed consent  form and assured that their participation was voluntary, anonymous, and  confidential. Consent for publication: Not applicable. Competing interests: Simon  Baron-Cohen is the previous Editor-in-Chief of Molecular Autism. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic communities in Europe continue to face difficulties accessing services despite increasing rates of autism diagnosis in recent years. METHODS: To investigate autistic people's access to services in Europe and reasons for unsuccessful access, we conducted the ACCESS-EU survey comprising of 2322 formally diagnosed autistic people and family carers living within the European Union (EU) and the United Kingdom (UK). The survey also examined age group (adult vs. child) and gender (male vs. female) differences in results. RESULTS: Overall, autistic people reported access to therapy (33.38%), mental health (29.89%), educational (27.05%), medical (34.28%), financial (26.66%), needs assessment (14.90%), information/referral (14.73%), social care (14.43%), employment (7.54%), housing (6.80%), legal (3.96%), helpline (3.40%) and other services (0.26%), and most (≥ 57.61%) had waited up to 6 months from referral to access most services. Several respondents were also unable to access therapeutic (13.53%), mental health (11.90%), autism diagnostic (5.92%), needs assessment (8.32%), financial (9.62%), educational (8.10%), social care (7.39%), information/referral (6.14%), medical (7.28%), housing (5.92%), employment (5.43%), legal (3.42%), and helpline services (2.34%). Reasons cited by respondents for their unsuccessful service access included service unavailability (23.08%), service unsuitability or participant ineligibility (20.04%), long waitlists (17.42%), service unaffordability (11.80%), and rejection from service due to autism diagnosis (9.87%), along with other reasons not listed in the survey (18.42%). Significant age group and gender differences were observed for successful access to services, waiting time, unsuccessful access and reasons for unsuccessful access. Among the five most represented countries in the survey-the UK (33.33%), Spain (14.04%), Poland (13.87%), France (11.07%) and Germany (6.03%)-overall service access was most inconsistent in Poland and the UK, highest in Germany and Spain but poorest in France. LIMITATIONS: Issues related to survey presentation such as the languages in which the survey was conducted and the phrasing of some questions should be considered, as well as issues regarding subjectivity and ambiguity of data analysis such as translation of non-English responses into English. CONCLUSIONS: Our findings suggest that service access among autistic people in Europe is inconsistent. Significant improvement to current policies is required to enhance access to services across Europe. En ligne : https://dx.doi.org/10.1186/s13229-025-00664-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Access to services for autistic people across Europe [texte imprimé] / Siti Nurnadhirah BINTE MOHD IKHSAN, Auteur ; Rosemary HOLT, Auteur ; Joyce MAN, Auteur ; Tracey PARSONS, Auteur ; Rik SCHALBROECK, Auteur ; Amber RUIGROK, Auteur ; Aurélie BARANGER, Auteur ; Carrie ALLISON, Auteur ; Mary DOHERTY, Auteur ; Katrien VAN DEN BOSCH, Auteur ; Jerneja TERÄŒON, Auteur ; Pierre VIOLLAND, Auteur ; Anjuli GHOSH, Auteur ; James CUSACK, Auteur ; Simon BARON-COHEN, Auteur ; Siti Nurnadhirah BINTE MOHD IKHSAN, Auteur ; Rosemary HOLT, Auteur ; Joyce MAN, Auteur ; Tracey PARSONS, Auteur ; Rik SCHALBROECK, Auteur ; Amber RUIGROK, Auteur ; Aurélie BARANGER, Auteur ; Carrie ALLISON, Auteur ; Mary DOHERTY, Auteur ; Katrien VAN DEN BOSCH, Auteur ; Jerneja TERÄŒON, Auteur ; Pierre VIOLLAND, Auteur ; Anjuli GHOSH, Auteur ; James CUSACK, Auteur ; Simon BARON-COHEN, Auteur . - 35. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 35 Mots-clés : Humans  Male  Health Services Accessibility/statistics & numerical data  Female  Adult  Autistic Disorder/therapy/epidemiology/diagnosis  Europe/epidemiology  Adolescent  Middle Aged  Child  Young Adult  Surveys and Questionnaires  United Kingdom  Autism  Europe  Policy  Service access  Service barriers  Services  Survey  conducted in accordance with the principles outlined in the Declaration of  Helsinki. All participants gave written informed consent in the ACCESS-EU study,  which was approved by the Cambridge Psychology Research Ethics Committee  (reference number PRE.2019.088). As this research involved an online survey, it  adhered to ethical standards for informed consent, participant confidentiality,  and data protection. All participants were provided with a clear informed consent  form and assured that their participation was voluntary, anonymous, and  confidential. Consent for publication: Not applicable. Competing interests: Simon  Baron-Cohen is the previous Editor-in-Chief of Molecular Autism. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic communities in Europe continue to face difficulties accessing services despite increasing rates of autism diagnosis in recent years. METHODS: To investigate autistic people's access to services in Europe and reasons for unsuccessful access, we conducted the ACCESS-EU survey comprising of 2322 formally diagnosed autistic people and family carers living within the European Union (EU) and the United Kingdom (UK). The survey also examined age group (adult vs. child) and gender (male vs. female) differences in results. RESULTS: Overall, autistic people reported access to therapy (33.38%), mental health (29.89%), educational (27.05%), medical (34.28%), financial (26.66%), needs assessment (14.90%), information/referral (14.73%), social care (14.43%), employment (7.54%), housing (6.80%), legal (3.96%), helpline (3.40%) and other services (0.26%), and most (≥ 57.61%) had waited up to 6 months from referral to access most services. Several respondents were also unable to access therapeutic (13.53%), mental health (11.90%), autism diagnostic (5.92%), needs assessment (8.32%), financial (9.62%), educational (8.10%), social care (7.39%), information/referral (6.14%), medical (7.28%), housing (5.92%), employment (5.43%), legal (3.42%), and helpline services (2.34%). Reasons cited by respondents for their unsuccessful service access included service unavailability (23.08%), service unsuitability or participant ineligibility (20.04%), long waitlists (17.42%), service unaffordability (11.80%), and rejection from service due to autism diagnosis (9.87%), along with other reasons not listed in the survey (18.42%). Significant age group and gender differences were observed for successful access to services, waiting time, unsuccessful access and reasons for unsuccessful access. Among the five most represented countries in the survey-the UK (33.33%), Spain (14.04%), Poland (13.87%), France (11.07%) and Germany (6.03%)-overall service access was most inconsistent in Poland and the UK, highest in Germany and Spain but poorest in France. LIMITATIONS: Issues related to survey presentation such as the languages in which the survey was conducted and the phrasing of some questions should be considered, as well as issues regarding subjectivity and ambiguity of data analysis such as translation of non-English responses into English. CONCLUSIONS: Our findings suggest that service access among autistic people in Europe is inconsistent. Significant improvement to current policies is required to enhance access to services across Europe. En ligne : https://dx.doi.org/10.1186/s13229-025-00664-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Autistic People?s Perinatal Experiences I: A Survey of Pregnancy Experiences / Carrie ALLISON ; Simon BARON-COHEN ; Rosemary HOLT in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.211-223 Titre : Autistic People?s Perinatal Experiences I: A Survey of Pregnancy Experiences Type de document : texte imprimé Auteurs : Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Rosemary HOLT, Auteur Article en page(s) : p.211-223 Index. décimale : PER Périodiques Résumé : Qualitative studies of autistic people?s pregnancy experiences have indicated sensory and communication related barriers to accessing adequate prenatal healthcare. However, quantitative work on the topic is scarce. This online survey study explored pregnancy experiences among 417 autistic and 524 non-autistic people. Compared with non-autistic people, autistic people reported heightened sensory and physical experiences during pregnancy and were more likely to experience prenatal depression and anxiety. Autistic people experienced lower satisfaction with prenatal healthcare, including having lower perceptions of their relationships with healthcare professionals and greater difficulties with antenatal classes. This study identifies key adjustments that can be made to prenatal healthcare, including sensory and communication adjustments. The findings highlight the need for greater autism understanding and awareness among professionals. En ligne : https://doi.org/10.1007/s10803-022-05754-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] Autistic People?s Perinatal Experiences I: A Survey of Pregnancy Experiences [texte imprimé] / Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Rosemary HOLT, Auteur . - p.211-223. in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.211-223 Index. décimale : PER Périodiques Résumé : Qualitative studies of autistic people?s pregnancy experiences have indicated sensory and communication related barriers to accessing adequate prenatal healthcare. However, quantitative work on the topic is scarce. This online survey study explored pregnancy experiences among 417 autistic and 524 non-autistic people. Compared with non-autistic people, autistic people reported heightened sensory and physical experiences during pregnancy and were more likely to experience prenatal depression and anxiety. Autistic people experienced lower satisfaction with prenatal healthcare, including having lower perceptions of their relationships with healthcare professionals and greater difficulties with antenatal classes. This study identifies key adjustments that can be made to prenatal healthcare, including sensory and communication adjustments. The findings highlight the need for greater autism understanding and awareness among professionals. En ligne : https://doi.org/10.1007/s10803-022-05754-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

Facial expression recognition is linked to clinical and neurofunctional differences in autism / Hannah MEYER-LINDENBERG in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 43 p. Titre : Facial expression recognition is linked to clinical and neurofunctional differences in autism Type de document : texte imprimé Auteurs : Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J. H. JONES, Auteur ; Hannah L. HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur Article en page(s) : 43 p. Langues : Anglais (eng) Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Facial expression recognition is linked to clinical and neurofunctional differences in autism [texte imprimé] / Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J. H. JONES, Auteur ; Hannah L. HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur . - 43 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 43 p. Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Failure to deactivate the default mode network indicates a possible endophenotype of autism / Michael D. SPENCER in Molecular Autism, (December 2012)  

Public ISBD [article]  inMolecular Autism > (December 2012) . - 9 p. Titre : Failure to deactivate the default mode network indicates a possible endophenotype of autism Type de document : texte imprimé Auteurs : Michael D. SPENCER, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary HOLT, Auteur ; John SUCKLING, Auteur ; Andrew J. CALDER, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur Année de publication : 2012 Article en page(s) : 9 p. Langues : Anglais (eng) Mots-clés : Autism  Default mode network  Functional MRI  Endophenotype Index. décimale : PER Périodiques Résumé : BACKGROUND:Reduced activity during cognitively demanding tasks has been reported in the default mode network in typically developing controls and individuals with autism. However, no study has investigated the default mode network (DMN) in first-degree relatives of those with autism (such as siblings) and it is not known whether atypical activation of the DMN is specific to autism or whether it is also present in unaffected relatives. Here we use functional magnetic resonance imaging to investigate the pattern of task-related deactivation during completion of a visual search task, the Embedded Figures Task, in teenagers with autism, their unaffected siblings and typically developing controls.FINDINGS:We identified striking reductions in deactivation during the Embedded Figures Task in unaffected siblings compared to controls in brain regions corresponding to the default mode network. Adolescents with autism and their unaffected siblings similarly failed to deactivate regions, including posterior cingulate and bilateral inferior parietal cortex.CONCLUSIONS:This suggests that a failure to deactivate these regions is a functional endophenotype of autism, related to familial risk for the condition shared between individuals with autism and their siblings. En ligne : http://dx.doi.org/10.1186/2040-2392-3-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Failure to deactivate the default mode network indicates a possible endophenotype of autism [texte imprimé] / Michael D. SPENCER, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary HOLT, Auteur ; John SUCKLING, Auteur ; Andrew J. CALDER, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur . - 2012 . - 9 p. Langues : Anglais (eng) in Molecular Autism > (December 2012) . - 9 p. Mots-clés : Autism  Default mode network  Functional MRI  Endophenotype Index. décimale : PER Périodiques Résumé : BACKGROUND:Reduced activity during cognitively demanding tasks has been reported in the default mode network in typically developing controls and individuals with autism. However, no study has investigated the default mode network (DMN) in first-degree relatives of those with autism (such as siblings) and it is not known whether atypical activation of the DMN is specific to autism or whether it is also present in unaffected relatives. Here we use functional magnetic resonance imaging to investigate the pattern of task-related deactivation during completion of a visual search task, the Embedded Figures Task, in teenagers with autism, their unaffected siblings and typically developing controls.FINDINGS:We identified striking reductions in deactivation during the Embedded Figures Task in unaffected siblings compared to controls in brain regions corresponding to the default mode network. Adolescents with autism and their unaffected siblings similarly failed to deactivate regions, including posterior cingulate and bilateral inferior parietal cortex.CONCLUSIONS:This suggests that a failure to deactivate these regions is a functional endophenotype of autism, related to familial risk for the condition shared between individuals with autism and their siblings. En ligne : http://dx.doi.org/10.1186/2040-2392-3-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Fetal brain growth and infant autistic traits / Ezra AYDIN in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 11p. Titre : Fetal brain growth and infant autistic traits Type de document : texte imprimé Auteurs : Ezra AYDIN, Auteur ; Alex TSOMPANIDIS, Auteur ; Daren CHAPLIN, Auteur ; Rebecca HAWKES, Auteur ; Carrie ALLISON, Auteur ; Gerald HACKETT, Auteur ; Topun AUSTIN, Auteur ; EglÄ— PADAIGAITÄ–, Auteur ; Lidia V. GABIS, Auteur ; John SUCKING, Auteur ; Rosemary HOLT, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 11p. Langues : Anglais (eng) Mots-clés : Male  Infant  Pregnancy  Female  Humans  Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  Gestational Age  Autistic traits  Early brain development  Q-chat  Transcerebellar diameter  Ultrasound Index. décimale : PER Périodiques Résumé : BACKGROUND: Structural differences exist in the brains of autistic individuals. To date only a few studies have explored the relationship between fetal brain growth and later infant autistic traits, and some have used fetal head circumference (HC) as a proxy for brain development. These findings have been inconsistent. Here we investigate whether fetal subregional brain measurements correlate with autistic traits in toddlers. METHODS: A total of 219 singleton pregnancies (104 males and 115 females) were recruited at the Rosie Hospital, Cambridge, UK. 2D ultrasound was performed at 12-, 20- and between 26 and 30 weeks of pregnancy, measuring head circumference (HC), ventricular atrium (VA) and transcerebellar diameter (TCD). A total of 179 infants were followed up at 18-20 months of age and completed the quantitative checklist for autism in toddlers (Q-CHAT) to measure autistic traits. RESULTS: Q-CHAT scores at 18-20 months of age were positively associated with TCD size at 20 weeks and with HC at 28 weeks, in univariate analyses, and in multiple regression models which controlled for sex, maternal age and birth weight. LIMITATIONS: Due to the nature and location of the study, ascertainment bias could also have contributed to the recruitment of volunteer mothers with a higher than typical range of autistic traits and/or with a significant interest in the neurodevelopment of their children. CONCLUSION: Prenatal brain growth is associated with toddler autistic traits and this can be ascertained via ultrasound starting at 20 weeks gestation. En ligne : https://dx.doi.org/10.1186/s13229-024-00586-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Fetal brain growth and infant autistic traits [texte imprimé] / Ezra AYDIN, Auteur ; Alex TSOMPANIDIS, Auteur ; Daren CHAPLIN, Auteur ; Rebecca HAWKES, Auteur ; Carrie ALLISON, Auteur ; Gerald HACKETT, Auteur ; Topun AUSTIN, Auteur ; EglÄ— PADAIGAITÄ–, Auteur ; Lidia V. GABIS, Auteur ; John SUCKING, Auteur ; Rosemary HOLT, Auteur ; Simon BARON-COHEN, Auteur . - 11p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 11p. Mots-clés : Male  Infant  Pregnancy  Female  Humans  Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  Gestational Age  Autistic traits  Early brain development  Q-chat  Transcerebellar diameter  Ultrasound Index. décimale : PER Périodiques Résumé : BACKGROUND: Structural differences exist in the brains of autistic individuals. To date only a few studies have explored the relationship between fetal brain growth and later infant autistic traits, and some have used fetal head circumference (HC) as a proxy for brain development. These findings have been inconsistent. Here we investigate whether fetal subregional brain measurements correlate with autistic traits in toddlers. METHODS: A total of 219 singleton pregnancies (104 males and 115 females) were recruited at the Rosie Hospital, Cambridge, UK. 2D ultrasound was performed at 12-, 20- and between 26 and 30 weeks of pregnancy, measuring head circumference (HC), ventricular atrium (VA) and transcerebellar diameter (TCD). A total of 179 infants were followed up at 18-20 months of age and completed the quantitative checklist for autism in toddlers (Q-CHAT) to measure autistic traits. RESULTS: Q-CHAT scores at 18-20 months of age were positively associated with TCD size at 20 weeks and with HC at 28 weeks, in univariate analyses, and in multiple regression models which controlled for sex, maternal age and birth weight. LIMITATIONS: Due to the nature and location of the study, ascertainment bias could also have contributed to the recruitment of volunteer mothers with a higher than typical range of autistic traits and/or with a significant interest in the neurodevelopment of their children. CONCLUSION: Prenatal brain growth is associated with toddler autistic traits and this can be ascertained via ultrasound starting at 20 weeks gestation. En ligne : https://dx.doi.org/10.1186/s13229-024-00586-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project / Bethany OAKLEY in Autism, 25-2 (February 2021)  

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Is the association between mothers' autistic traits and childhood autistic traits moderated by maternal pre-pregnancy body mass index? / Alexandros TSOMPANIDIS ; Rama J. WAHAB ; Romy GAILLARD ; Ezra AYDIN ; Rosemary HOLT ; Carrie ALLISON ; Simon BARON-COHEN ; Marinus H. VAN IJZENDOORN ; Pauline W. JANSEN in Molecular Autism, 14 (2023)  

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Moral foundations in autistic people and people with systemizing minds / Yeshaya David M. GREENBERG in Molecular Autism, 15 (2024)  

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A qualitative exploration of autistic mothers' experiences I: Pregnancy experiences / Sarah HAMPTON in Autism, 27-5 (July 2023)  

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Revised scored Sensory Perception Quotient reveals sensory hypersensitivity in women with autism / Emily TAYLOR in Molecular Autism, 11 (2020)  

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Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project / Carolin MOESSNANG in Molecular Autism, 11 (2020)  

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