Dépouillements

Toilet training interventions for children with autism spectrum disorder: A systematic review / Megan SIMON in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102049 Titre : Toilet training interventions for children with autism spectrum disorder: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Megan SIMON, Auteur ; Sarah WILKES-GILLAN, Auteur ; Yu-Wei RYAN CHEN, Auteur ; Reinie CORDIER, Auteur ; Alycia CANTRILL, Auteur ; Lauren PARSONS, Auteur ; Jia Jun PHUA, Auteur Article en page(s) : 102049 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Autistic disorder  Children  Toilet training  Systematic review Index. décimale : PER Périodiques Résumé : Background Children on the autism spectrum can often reach independence in toileting at a later age than nonautistic children, which impacts their health outcomes, independence and social participation. This study aimed to systematically review evidence-based toilet training interventions for children on the autism spectrum, and assess the quality of existing evidence. Method Guided by the PRISMA statement, a search of scholarly databases was conducted and the study characteristics, methodological quality and intervention components of included studies were examined. Results This systematic review identified 26 studies that evaluated toilet training interventions for children on the autism spectrum. Results identified that while Azrin and Foxx’s (1971) Rapid Toilet Training approach is most widely researched for children on the autism spectrum, investigating the effects of current toilet training approaches is limited by small sample sizes, low-level study designs and variable methods of reporting outcomes. Conclusion Greater consideration of parent-child communication, children’s developmental and toileting skill level may facilitate development of toileting approaches that better meet the needs of children on the autism spectrum and their families. En ligne : https://doi.org/10.1016/j.rasd.2022.102049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Toilet training interventions for children with autism spectrum disorder: A systematic review [Texte imprimé et/ou numérique] / Megan SIMON, Auteur ; Sarah WILKES-GILLAN, Auteur ; Yu-Wei RYAN CHEN, Auteur ; Reinie CORDIER, Auteur ; Alycia CANTRILL, Auteur ; Lauren PARSONS, Auteur ; Jia Jun PHUA, Auteur . - 102049. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102049 Mots-clés : Autism spectrum disorder  Autistic disorder  Children  Toilet training  Systematic review Index. décimale : PER Périodiques Résumé : Background Children on the autism spectrum can often reach independence in toileting at a later age than nonautistic children, which impacts their health outcomes, independence and social participation. This study aimed to systematically review evidence-based toilet training interventions for children on the autism spectrum, and assess the quality of existing evidence. Method Guided by the PRISMA statement, a search of scholarly databases was conducted and the study characteristics, methodological quality and intervention components of included studies were examined. Results This systematic review identified 26 studies that evaluated toilet training interventions for children on the autism spectrum. Results identified that while Azrin and Foxx’s (1971) Rapid Toilet Training approach is most widely researched for children on the autism spectrum, investigating the effects of current toilet training approaches is limited by small sample sizes, low-level study designs and variable methods of reporting outcomes. Conclusion Greater consideration of parent-child communication, children’s developmental and toileting skill level may facilitate development of toileting approaches that better meet the needs of children on the autism spectrum and their families. En ligne : https://doi.org/10.1016/j.rasd.2022.102049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Parenting stress within mother-father dyads raising a young child with autism spectrum disorder / Shaneha PATEL in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102051 Titre : Parenting stress within mother-father dyads raising a young child with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Shaneha PATEL, Auteur ; Mélina RIVARD, Auteur ; Catherine MELLO, Auteur ; Diane MORIN, Auteur Article en page(s) : 102051 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  children  parenting stress  longitudinal  specialized intervention services Index. décimale : PER Périodiques Résumé : Background The present study assessed different facets of parenting stress in families with a child with ASD (perceptions of parenting-related roles, parent-child interactions, and the child’s behaviors) at three timepoints: right after receiving an ASD diagnosis, immediately following specialized intervention services, and one year after receiving services, upon primary school entry. Method Participants were 258 mother-father dyads and their child. Parents provided demographic information and completed measures on their parenting stress and their child’s autism symptom severity. Results Partial correlations revealed that, at the time of diagnosis, after controlling for children’s age and autism symptom severity, mothers’ and fathers’ stress was positively and significantly associated with each other, suggesting a bidirectional relation between partners’ psychological adjustment. Cross-lagged panel analyses demonstrated different longitudinal and transactional links, depending on the dimension of stress examined. Conclusions Findings are discussed in terms of supports that could assist mothers and fathers of children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102051 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Parenting stress within mother-father dyads raising a young child with autism spectrum disorder [Texte imprimé et/ou numérique] / Shaneha PATEL, Auteur ; Mélina RIVARD, Auteur ; Catherine MELLO, Auteur ; Diane MORIN, Auteur . - 102051. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102051 Mots-clés : Autism spectrum disorder  children  parenting stress  longitudinal  specialized intervention services Index. décimale : PER Périodiques Résumé : Background The present study assessed different facets of parenting stress in families with a child with ASD (perceptions of parenting-related roles, parent-child interactions, and the child’s behaviors) at three timepoints: right after receiving an ASD diagnosis, immediately following specialized intervention services, and one year after receiving services, upon primary school entry. Method Participants were 258 mother-father dyads and their child. Parents provided demographic information and completed measures on their parenting stress and their child’s autism symptom severity. Results Partial correlations revealed that, at the time of diagnosis, after controlling for children’s age and autism symptom severity, mothers’ and fathers’ stress was positively and significantly associated with each other, suggesting a bidirectional relation between partners’ psychological adjustment. Cross-lagged panel analyses demonstrated different longitudinal and transactional links, depending on the dimension of stress examined. Conclusions Findings are discussed in terms of supports that could assist mothers and fathers of children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102051 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

PDE3 inhibition by cilostazol attenuated developmental hyperserotonemia induced behavioural and biochemical deficits in a rat model of autism spectrum disorder / Kanishk LUHACH in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102052 Titre : PDE3 inhibition by cilostazol attenuated developmental hyperserotonemia induced behavioural and biochemical deficits in a rat model of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kanishk LUHACH, Auteur ; Bhagwat SINGH, Auteur ; Himanshu AGGARWAL, Auteur ; Bhupesh SHARMA, Auteur Article en page(s) : 102052 Langues : Anglais (eng) Mots-clés : Developmental hyperserotonemia  Phosphodiesterase 3  BDNF  Neuroinflammation  Oxidative stress Index. décimale : PER Périodiques Résumé : Background Hyperserotonemia, in the early developmental phase generates behavioural and biochemical phenotypes associated with autism spectrum disorder (ASD) in rats. Phosphodiesterase-3 (PDE3) inhibition by cilostazol has been shown to provide benefits in various brain conditions. We investigated the role of a selective PDE3 inhibitor cilostazol on ASD related behavioural phenotypes. Method Administration of 5-Methoxytryptamine (5-MT) to rats perinatally (GD12-Parturition) and in early developmental stages (PND0-PND20), resulted into developmental hyperserotonemia (DHS). DHS associated behavioural changes (social behaviour deficits, repetitive behaviour, anxiety and hyperlocomotion) were assessed using a battery of behavioural examinations. Also, effect on biochemical markers related with neuronal function (BDNF - neuronal survival and pCREB - neuronal transcription factor), inflammation (IL-6, IL-10 and TNF-Î+) and oxidative stress (TBARS and GSH) were studied in important brain areas (frontal cortex, cerebellum, hippocampus, and striatum). Cilostazol was administered in two doses 30 & 60 mg.kg-1 p.o. each day to male rats from PND21 to PND48. Result Administration of cilostazol to 5-MT rats resulted in improvement of behavioural deficits. Also, cilostazol administration significantly increased the levels of BDNF, pCREB, IL-10, GSH and significantly decreased TNF-Î+, IL-6 and TBARS levels in different brain areas. Conclusion DHS during prenatal and early postnatal developmental stages leads to pervasive harm to the serotonergic system, leading to prolonged effects as observed via behavioural and biochemical outcomes of the study. Serotonin regulates early brain neurogenesis, synaptogenesis, and neuronal differentiation probably via the CREB/BDNF pathway and DHS is known to reduce the activity of CREB/BDNF pathway. Cilostazol administration to pups exposed to DHS perinatally has resulted in increase of neurotrophic factors, reduced inflammation and reduced oxidative stress, probably via increased cAMP/CREB/BDNF signalling. Also, improvement in behavioural profile of animals subjected to DHS. Thus, PDE3 and its inhibitors could be considered as molecules of interest for research in developmental disorders. En ligne : https://doi.org/10.1016/j.rasd.2022.102052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] PDE3 inhibition by cilostazol attenuated developmental hyperserotonemia induced behavioural and biochemical deficits in a rat model of autism spectrum disorder [Texte imprimé et/ou numérique] / Kanishk LUHACH, Auteur ; Bhagwat SINGH, Auteur ; Himanshu AGGARWAL, Auteur ; Bhupesh SHARMA, Auteur . - 102052. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102052 Mots-clés : Developmental hyperserotonemia  Phosphodiesterase 3  BDNF  Neuroinflammation  Oxidative stress Index. décimale : PER Périodiques Résumé : Background Hyperserotonemia, in the early developmental phase generates behavioural and biochemical phenotypes associated with autism spectrum disorder (ASD) in rats. Phosphodiesterase-3 (PDE3) inhibition by cilostazol has been shown to provide benefits in various brain conditions. We investigated the role of a selective PDE3 inhibitor cilostazol on ASD related behavioural phenotypes. Method Administration of 5-Methoxytryptamine (5-MT) to rats perinatally (GD12-Parturition) and in early developmental stages (PND0-PND20), resulted into developmental hyperserotonemia (DHS). DHS associated behavioural changes (social behaviour deficits, repetitive behaviour, anxiety and hyperlocomotion) were assessed using a battery of behavioural examinations. Also, effect on biochemical markers related with neuronal function (BDNF - neuronal survival and pCREB - neuronal transcription factor), inflammation (IL-6, IL-10 and TNF-Î+) and oxidative stress (TBARS and GSH) were studied in important brain areas (frontal cortex, cerebellum, hippocampus, and striatum). Cilostazol was administered in two doses 30 & 60 mg.kg-1 p.o. each day to male rats from PND21 to PND48. Result Administration of cilostazol to 5-MT rats resulted in improvement of behavioural deficits. Also, cilostazol administration significantly increased the levels of BDNF, pCREB, IL-10, GSH and significantly decreased TNF-Î+, IL-6 and TBARS levels in different brain areas. Conclusion DHS during prenatal and early postnatal developmental stages leads to pervasive harm to the serotonergic system, leading to prolonged effects as observed via behavioural and biochemical outcomes of the study. Serotonin regulates early brain neurogenesis, synaptogenesis, and neuronal differentiation probably via the CREB/BDNF pathway and DHS is known to reduce the activity of CREB/BDNF pathway. Cilostazol administration to pups exposed to DHS perinatally has resulted in increase of neurotrophic factors, reduced inflammation and reduced oxidative stress, probably via increased cAMP/CREB/BDNF signalling. Also, improvement in behavioural profile of animals subjected to DHS. Thus, PDE3 and its inhibitors could be considered as molecules of interest for research in developmental disorders. En ligne : https://doi.org/10.1016/j.rasd.2022.102052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

The association between motor coordination impairment and restricted/repetitive behaviors in autistic children: The partial mediating effect of executive function / Chengkai JIN in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102053 Titre : The association between motor coordination impairment and restricted/repetitive behaviors in autistic children: The partial mediating effect of executive function Type de document : Texte imprimé et/ou numérique Auteurs : Chengkai JIN, Auteur ; Tingfeng GU, Auteur ; Bijun SHI, Auteur ; Xin WANG, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur Article en page(s) : 102053 Langues : Anglais (eng) Mots-clés : Motor coordination  Motor impairment  Restricted/repetitive behaviors  Executive function  Autism Index. décimale : PER Périodiques Résumé : Background It has been strongly argued that impaired motor function contributes to the restricted/repetitive behaviors (RRBs) of autistic children, but the mechanism exploration of these claims has been limited by the absence of potential confounders such as executive function. Method We investigated the role that executive function (EF) plays in the relationship between motor coordination, EF, and RRBs in a school-aged autism population (n = 188, age = 7.42 Â+ 1.46 years, 86.7% males) via a structural equation model in a statistically robust way. The Developmental Coordination Disorder Questionnaire, Behavior Rating Inventory of Executive Function, and Restrictive Behavior Scale-Revised were collected to measure motor coordination, EF, and RRBs, respectively. Results Among the participants, 33.5% (n = 63) were classified as intellectual disability, 46.8% (n = 88) had EF dysfunction and 35.1% (n = 66) had motor coordination impairment. We found a direct effect of motor coordination impairment on RRBs among children with ASD and without intellectual disability (Î2= -0.334, p<0.001), as well as an indirect effect through EF, which was a partial mediator of the relationship (Î2= â’0.140, p = 0.001). Conclusions Motor coordination impairment should be included in the routine evaluation of autism surveillance and rehabilitation procedure, to address the ASD children who need additional support. It is important to add motor skills and motor coordination training in the daily intervention of autism, which could also improve EF and decrease RRBs in these children. En ligne : https://doi.org/10.1016/j.rasd.2022.102053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] The association between motor coordination impairment and restricted/repetitive behaviors in autistic children: The partial mediating effect of executive function [Texte imprimé et/ou numérique] / Chengkai JIN, Auteur ; Tingfeng GU, Auteur ; Bijun SHI, Auteur ; Xin WANG, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur . - 102053. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102053 Mots-clés : Motor coordination  Motor impairment  Restricted/repetitive behaviors  Executive function  Autism Index. décimale : PER Périodiques Résumé : Background It has been strongly argued that impaired motor function contributes to the restricted/repetitive behaviors (RRBs) of autistic children, but the mechanism exploration of these claims has been limited by the absence of potential confounders such as executive function. Method We investigated the role that executive function (EF) plays in the relationship between motor coordination, EF, and RRBs in a school-aged autism population (n = 188, age = 7.42 Â+ 1.46 years, 86.7% males) via a structural equation model in a statistically robust way. The Developmental Coordination Disorder Questionnaire, Behavior Rating Inventory of Executive Function, and Restrictive Behavior Scale-Revised were collected to measure motor coordination, EF, and RRBs, respectively. Results Among the participants, 33.5% (n = 63) were classified as intellectual disability, 46.8% (n = 88) had EF dysfunction and 35.1% (n = 66) had motor coordination impairment. We found a direct effect of motor coordination impairment on RRBs among children with ASD and without intellectual disability (Î2= -0.334, p<0.001), as well as an indirect effect through EF, which was a partial mediator of the relationship (Î2= â’0.140, p = 0.001). Conclusions Motor coordination impairment should be included in the routine evaluation of autism surveillance and rehabilitation procedure, to address the ASD children who need additional support. It is important to add motor skills and motor coordination training in the daily intervention of autism, which could also improve EF and decrease RRBs in these children. En ligne : https://doi.org/10.1016/j.rasd.2022.102053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study / Lauren GRANILLO in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102054 Titre : Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Lauren GRANILLO, Auteur ; Ana-Maria IOSIF, Auteur ; Amanda GOODRICH, Auteur ; Nathaniel W. SNYDER, Auteur ; Rebecca J. SCHMIDT, Auteur Article en page(s) : 102054 Langues : Anglais (eng) Mots-clés : Testosterone  Androstenedione  Autism  Pregnancy  Prospective study Index. décimale : PER Périodiques Résumé : Background Maternal hormonal risk factors for autism spectrum disorder (ASD) in offspring could intersect genetic and environmental risk factors. Objectives This analysis explored ASD risk in association with maternal testosterone, androstenedione, and dehydroepiandrosterone (DHEA) measured in first, second, and third trimesters of pregnancy. Methods MARBLES is a prospective pregnancy cohort study based at the MIND Institute in Northern California that enrolls mothers who have at least one child previously diagnosed with ASD and are expecting, or planning to have another child. At 36 months the younger sibling is clinically classified as having ASD, or as non-typically developing (Non-TD), or typically developing (TD). Maternal androgens during pregnancy were measured in serum samples from 196 mothers. Multivariable logistic regression models estimated risk of ASD and Non-TD in offspring compared to TD, in relation to the log-transformed maternal androgen concentrations, at each trimester. Results Non-significant associations were observed, and borderline significant associations were only observed in some stratified unadjusted models. Second trimester maternal testosterone was non-significantly associated with ASD in female offspring, although not after adjustment, aRR 1.54 (95% CI 0.71, 3.33), and second trimester maternal DHEA was non-significantly associated with non-TD in male offspring, again not after adjustment, aRR 0.50 (95% CI 0.21, 1.21). Secondary analysis suggested that third trimester androgen concentrations in mothers with male offspring had significant or near significant associations with their child’s Social Responsiveness Scale score. Conclusion No significant associations were found between maternal androgen concentrations and risk of ASD or Non-TD in the child. En ligne : https://doi.org/10.1016/j.rasd.2022.102054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study [Texte imprimé et/ou numérique] / Lauren GRANILLO, Auteur ; Ana-Maria IOSIF, Auteur ; Amanda GOODRICH, Auteur ; Nathaniel W. SNYDER, Auteur ; Rebecca J. SCHMIDT, Auteur . - 102054. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102054 Mots-clés : Testosterone  Androstenedione  Autism  Pregnancy  Prospective study Index. décimale : PER Périodiques Résumé : Background Maternal hormonal risk factors for autism spectrum disorder (ASD) in offspring could intersect genetic and environmental risk factors. Objectives This analysis explored ASD risk in association with maternal testosterone, androstenedione, and dehydroepiandrosterone (DHEA) measured in first, second, and third trimesters of pregnancy. Methods MARBLES is a prospective pregnancy cohort study based at the MIND Institute in Northern California that enrolls mothers who have at least one child previously diagnosed with ASD and are expecting, or planning to have another child. At 36 months the younger sibling is clinically classified as having ASD, or as non-typically developing (Non-TD), or typically developing (TD). Maternal androgens during pregnancy were measured in serum samples from 196 mothers. Multivariable logistic regression models estimated risk of ASD and Non-TD in offspring compared to TD, in relation to the log-transformed maternal androgen concentrations, at each trimester. Results Non-significant associations were observed, and borderline significant associations were only observed in some stratified unadjusted models. Second trimester maternal testosterone was non-significantly associated with ASD in female offspring, although not after adjustment, aRR 1.54 (95% CI 0.71, 3.33), and second trimester maternal DHEA was non-significantly associated with non-TD in male offspring, again not after adjustment, aRR 0.50 (95% CI 0.21, 1.21). Secondary analysis suggested that third trimester androgen concentrations in mothers with male offspring had significant or near significant associations with their child’s Social Responsiveness Scale score. Conclusion No significant associations were found between maternal androgen concentrations and risk of ASD or Non-TD in the child. En ligne : https://doi.org/10.1016/j.rasd.2022.102054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Copy-number variants in the contactin-5 gene are a potential risk factor for autism spectrum disorder / Zoe SCHMILOVICH in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102055 Titre : Copy-number variants in the contactin-5 gene are a potential risk factor for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Zoe SCHMILOVICH, Auteur ; Guillaume HUGUET, Auteur ; Qin HE, Auteur ; Amélie MUSA-JOHNSON, Auteur ; Elise DOUARD, Auteur ; Mor Absa LOUM, Auteur ; Calwing LIAO, Auteur ; Jay P. ROSS, Auteur ; Alexandre DIONNE-LAPORTE, Auteur ; Dan SPIEGELMAN, Auteur ; Martineau JEAN-LOUIS, Auteur ; Zohra SACI, Auteur ; Caroline HAYWARD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Herve LEMAITRE, Auteur ; Gunter SCHUMANN, Auteur ; Lan XIONG, Auteur ; Patrick A. DION, Auteur ; Sébastien JACQUEMONT, Auteur ; Boris CHAUMETTE, Auteur ; Guy A. ROULEAU, Auteur Article en page(s) : 102055 Langues : Anglais (eng) Mots-clés : CNTN5  CNV  intronic deletions  neurodevelopment  inherited Index. décimale : PER Périodiques Résumé : Background Contactin-5 (CNTN5) is a candidate risk gene for autism spectrum disorder (ASD). Previous attempts to associate CNTN5 CNVs with ASD-susceptibility were limited by insufficient statistical power. Here, we aim to clarify the putative association between CNTN5 CNVs and ASD-risk using large-scale case-control analyses. Method A CNTN5 CNV, shared by four brothers in a multiplex family with ASD, was initially identified. We calculated the prevalence and transmission of CNTN5 CNVs in cases across five ASD cohorts (n=15,784). Second, we compared the prevalence of CNTN5 CNVs in cases to their unaffected siblings (n=4,996). Third, we assessed the enrichment of CNTN5 CNVs in cases to extrafamilial controls across three cohorts (n=24,886) and the UK Biobank (n = 459,862). Finally, we evaluated the clinical impact of CNTN5 CNVs in a broad neurodevelopmental disorder cohort and the DECIPHER database. Results Most (96.7%) CNTN5 CNV deletions (0.193%) and duplications (0.03%) in cases were inherited by a parent that transmitted the variant to their affected and unaffected children at the same rate. We identified a significant enrichment of intronic CNTN5 CNV deletions in cases compared to extrafamilial controls (0.178% versus 0.019%; p-value=1.68E-05; OR:8.51; 95%CI=[2.58-44.21]). There was no difference in CNTN5 CNV enrichment between cases and individuals with NDDs. Conclusions Intronic CNTN5 CNV deletions are rare, inherited, and intermediate effect size ASD-susceptibility variants that may also confer risk for other neuropsychiatric disorders. We offer a framework to characterize candidate variants that may not be detected through small-scale approaches to implicate intermediate effect size variants in the etiology of ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Copy-number variants in the contactin-5 gene are a potential risk factor for autism spectrum disorder [Texte imprimé et/ou numérique] / Zoe SCHMILOVICH, Auteur ; Guillaume HUGUET, Auteur ; Qin HE, Auteur ; Amélie MUSA-JOHNSON, Auteur ; Elise DOUARD, Auteur ; Mor Absa LOUM, Auteur ; Calwing LIAO, Auteur ; Jay P. ROSS, Auteur ; Alexandre DIONNE-LAPORTE, Auteur ; Dan SPIEGELMAN, Auteur ; Martineau JEAN-LOUIS, Auteur ; Zohra SACI, Auteur ; Caroline HAYWARD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Herve LEMAITRE, Auteur ; Gunter SCHUMANN, Auteur ; Lan XIONG, Auteur ; Patrick A. DION, Auteur ; Sébastien JACQUEMONT, Auteur ; Boris CHAUMETTE, Auteur ; Guy A. ROULEAU, Auteur . - 102055. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102055 Mots-clés : CNTN5  CNV  intronic deletions  neurodevelopment  inherited Index. décimale : PER Périodiques Résumé : Background Contactin-5 (CNTN5) is a candidate risk gene for autism spectrum disorder (ASD). Previous attempts to associate CNTN5 CNVs with ASD-susceptibility were limited by insufficient statistical power. Here, we aim to clarify the putative association between CNTN5 CNVs and ASD-risk using large-scale case-control analyses. Method A CNTN5 CNV, shared by four brothers in a multiplex family with ASD, was initially identified. We calculated the prevalence and transmission of CNTN5 CNVs in cases across five ASD cohorts (n=15,784). Second, we compared the prevalence of CNTN5 CNVs in cases to their unaffected siblings (n=4,996). Third, we assessed the enrichment of CNTN5 CNVs in cases to extrafamilial controls across three cohorts (n=24,886) and the UK Biobank (n = 459,862). Finally, we evaluated the clinical impact of CNTN5 CNVs in a broad neurodevelopmental disorder cohort and the DECIPHER database. Results Most (96.7%) CNTN5 CNV deletions (0.193%) and duplications (0.03%) in cases were inherited by a parent that transmitted the variant to their affected and unaffected children at the same rate. We identified a significant enrichment of intronic CNTN5 CNV deletions in cases compared to extrafamilial controls (0.178% versus 0.019%; p-value=1.68E-05; OR:8.51; 95%CI=[2.58-44.21]). There was no difference in CNTN5 CNV enrichment between cases and individuals with NDDs. Conclusions Intronic CNTN5 CNV deletions are rare, inherited, and intermediate effect size ASD-susceptibility variants that may also confer risk for other neuropsychiatric disorders. We offer a framework to characterize candidate variants that may not be detected through small-scale approaches to implicate intermediate effect size variants in the etiology of ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Methodological considerations in the use of standardized motor assessment tools for children with autism spectrum disorder: A scoping review / Osnat ATUN-EINY in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102064 Titre : Methodological considerations in the use of standardized motor assessment tools for children with autism spectrum disorder: A scoping review Type de document : Texte imprimé et/ou numérique Auteurs : Osnat ATUN-EINY, Auteur ; Siham AMIR-KAWAS, Auteur ; Tal KRASOVSKY, Auteur Article en page(s) : 102064 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  ASD  standardized motor assessment tools  motor development  scoping review Index. décimale : PER Périodiques Résumé : Background This scoping review identified methodological parameters affecting evaluation when administering standardized motor assessment tools among children with autism spectrum disorder (ASD). Method PubMed, CINAHL, PsycINFO, Scopus, ERIC and Web of Science were searched for English-language articles published 1/1990-8/2022. Studies of children with ASD, 3-18-years old, using performance-based standardized motor assessment tools, were included. ASD sample characteristics, enrollment criteria, accommodations and missing motor outcome data were synthesized. Results Among 5,432 references, 180 studies using 11 assessments were included. The most frequently used tools were the Movement Assessment Battery for Children, Bruininks-Oseretsky Test of Motor Proficiency and the Test of Gross Motor Development. Large-scale studies were lacking, and girls underrepresented. Low cognitive level was an exclusion criterion explicitly or as a related criterion in 87 (48%) studies. Behavioral issues were noted anecdotally. Methodological detail varied, particularly regarding missing data, administrators’ professions, training and inter-rater reliability. Seventy-four studies reported a total of 197 accommodations, related mainly to modifications of the tasks, accommodations to the testing procedure and changes in the physical setting in which the test was conducted. Conclusions The findings, building on previous reports, indicate that children and adolescents with ASD cannot be approached uniformly over the entire spectrum of intelligence (IQ) and behavioral profiles in motor assessments. Administration challenges may stem from ASD characteristics beyond cognitive ability. Inconsistency relating to the IQ variable and incomplete methodological reports continue to be obstacles to comparative conclusions. ASD-specific versions of the tools with a supplementary report, describing cooperation, off-task behaviors and engagement, and combining several tools are recommended. This review could inform development of guidelines regarding motor assessments for children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102064 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Methodological considerations in the use of standardized motor assessment tools for children with autism spectrum disorder: A scoping review [Texte imprimé et/ou numérique] / Osnat ATUN-EINY, Auteur ; Siham AMIR-KAWAS, Auteur ; Tal KRASOVSKY, Auteur . - 102064. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102064 Mots-clés : Autism spectrum disorder  ASD  standardized motor assessment tools  motor development  scoping review Index. décimale : PER Périodiques Résumé : Background This scoping review identified methodological parameters affecting evaluation when administering standardized motor assessment tools among children with autism spectrum disorder (ASD). Method PubMed, CINAHL, PsycINFO, Scopus, ERIC and Web of Science were searched for English-language articles published 1/1990-8/2022. Studies of children with ASD, 3-18-years old, using performance-based standardized motor assessment tools, were included. ASD sample characteristics, enrollment criteria, accommodations and missing motor outcome data were synthesized. Results Among 5,432 references, 180 studies using 11 assessments were included. The most frequently used tools were the Movement Assessment Battery for Children, Bruininks-Oseretsky Test of Motor Proficiency and the Test of Gross Motor Development. Large-scale studies were lacking, and girls underrepresented. Low cognitive level was an exclusion criterion explicitly or as a related criterion in 87 (48%) studies. Behavioral issues were noted anecdotally. Methodological detail varied, particularly regarding missing data, administrators’ professions, training and inter-rater reliability. Seventy-four studies reported a total of 197 accommodations, related mainly to modifications of the tasks, accommodations to the testing procedure and changes in the physical setting in which the test was conducted. Conclusions The findings, building on previous reports, indicate that children and adolescents with ASD cannot be approached uniformly over the entire spectrum of intelligence (IQ) and behavioral profiles in motor assessments. Administration challenges may stem from ASD characteristics beyond cognitive ability. Inconsistency relating to the IQ variable and incomplete methodological reports continue to be obstacles to comparative conclusions. ASD-specific versions of the tools with a supplementary report, describing cooperation, off-task behaviors and engagement, and combining several tools are recommended. This review could inform development of guidelines regarding motor assessments for children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102064 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Predicting typically-developing siblings’ acceptance of their sibling with ASD during emerging adulthood / Raaya ALON in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102065 Titre : Predicting typically-developing siblings’ acceptance of their sibling with ASD during emerging adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Raaya ALON, Auteur Article en page(s) : 102065 Langues : Anglais (eng) Mots-clés : siblings  acceptance  ASD  emerging adulthood  social support Index. décimale : PER Périodiques Résumé : Background Typically-developing siblings’ (TDS) acceptance of a brother or sister with AutismSpectrum Disorder (ASD) has been minimally explored, despite the life-long nature ofthese relationships and the potential impact on future involvement with and care of thesibling. This study focused on TDS during the complicated time of emerging adulthood, which is characterized by increasing independence and identity formation. Aims Grounded in Siblings Embedded Systems Framework, the study examined emergingadult TDS’ acceptance of their sibling with ASD, and variables predicting acceptance. Specifically, demographic variables, including those relating to emerging adulthood (marital status, occupation), internal resources (emotions towards siblings, optimism, sense of coherence) and social support were examined. Methods & procedures The study included 237 TDS (Mage=22) of children with ASD (Mage=17), andsome with ASD and intellectual developmental disorder (IDD). Participants completedsix self-report questionnaires. Results En ligne : https://doi.org/10.1016/j.rasd.2022.102065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Predicting typically-developing siblings’ acceptance of their sibling with ASD during emerging adulthood [Texte imprimé et/ou numérique] / Raaya ALON, Auteur . - 102065. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102065 Mots-clés : siblings  acceptance  ASD  emerging adulthood  social support Index. décimale : PER Périodiques Résumé : Background Typically-developing siblings’ (TDS) acceptance of a brother or sister with AutismSpectrum Disorder (ASD) has been minimally explored, despite the life-long nature ofthese relationships and the potential impact on future involvement with and care of thesibling. This study focused on TDS during the complicated time of emerging adulthood, which is characterized by increasing independence and identity formation. Aims Grounded in Siblings Embedded Systems Framework, the study examined emergingadult TDS’ acceptance of their sibling with ASD, and variables predicting acceptance. Specifically, demographic variables, including those relating to emerging adulthood (marital status, occupation), internal resources (emotions towards siblings, optimism, sense of coherence) and social support were examined. Methods & procedures The study included 237 TDS (Mage=22) of children with ASD (Mage=17), andsome with ASD and intellectual developmental disorder (IDD). Participants completedsix self-report questionnaires. Results En ligne : https://doi.org/10.1016/j.rasd.2022.102065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Meeting 24-hour movement guidelines: Their relationships with overweight and obesity among Chinese children with autism spectrum disorder / Wen Hong XU in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102066 Titre : Meeting 24-hour movement guidelines: Their relationships with overweight and obesity among Chinese children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Wen Hong XU, Auteur ; Jing QI, Auteur Article en page(s) : 102066 Langues : Anglais (eng) Mots-clés : Physical activity  Screen time  Sleep duration  Overweight  Obesity  Children  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Canada's and Australia's 24-hour movement guidelines for children and youth provide daily recommendations for physical activity (PA), screen time (ST), and sleep for optimal health. Previous studies have examined the associations between meeting these 24-hour movement guidelines and overweight and obesity among children without disabilities. Less is known about potential associations between the 24-hour movement behaviors and the weight status of children with disabilities. Therefore, the purpose of this study was to examine whether meeting movement behavior recommendations (i.e. ⥠60 min of Moderate-to-vigorous activity [MVPA] per day, 2 h of recreational ST per day, and 9-11 h of sleep for those aged 5-13 years [or 8-10 h for children aged 14-17 years]), and combinations of these recommendations, are associated with overweight and obesity in Chinese children with ASD. Method Participants were 99 children with autism spectrum disorder (ASD) 7-17 years old recruited from one Chinese special school. MVPA and nightly sleep duration were measured using 24-hour wrist-worn accelerometer. ST was reported by parents by using reliable and valid items derived from the Health Behavior in School-aged Children (Chinese version). A series of binary logical regression analyses were performed for analysis. Results Only 16.2% met all the three movement behavior recommendations. The proportions of children with ASD who met the recommendation for PA, ST, and sleep were 32.3%, 52.5%, and 65.7%, respectively. The children with ASD who met the MVPA (OR = 0.37, 95% CI: 0.15-0.94), MVPA + Sleep (OR = 0.27, 95% CI: 0.09-0.81), and all three 24-hour movement guidelines (OR = 0.14, 95% CI: 0.03-0.77), had significantly lower odds ratios for overweight/obesity than those who did not meet the respective recommendations. Conclusions Meeting the MVPA, MVPA + Sleep, and all three of the guidelines was associated with lower odds ratios for overweight and obesity in children with ASD, and MVPA was the single most important activity for weight control among this population. Therefore, meeting the 24-hour movement guidelines, especially the MVPA guideline should be considered an effective intervention and can inform the design of strategies and policies for the prevention of overweight and obesity in children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Meeting 24-hour movement guidelines: Their relationships with overweight and obesity among Chinese children with autism spectrum disorder [Texte imprimé et/ou numérique] / Wen Hong XU, Auteur ; Jing QI, Auteur . - 102066. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102066 Mots-clés : Physical activity  Screen time  Sleep duration  Overweight  Obesity  Children  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Canada's and Australia's 24-hour movement guidelines for children and youth provide daily recommendations for physical activity (PA), screen time (ST), and sleep for optimal health. Previous studies have examined the associations between meeting these 24-hour movement guidelines and overweight and obesity among children without disabilities. Less is known about potential associations between the 24-hour movement behaviors and the weight status of children with disabilities. Therefore, the purpose of this study was to examine whether meeting movement behavior recommendations (i.e. ⥠60 min of Moderate-to-vigorous activity [MVPA] per day, 2 h of recreational ST per day, and 9-11 h of sleep for those aged 5-13 years [or 8-10 h for children aged 14-17 years]), and combinations of these recommendations, are associated with overweight and obesity in Chinese children with ASD. Method Participants were 99 children with autism spectrum disorder (ASD) 7-17 years old recruited from one Chinese special school. MVPA and nightly sleep duration were measured using 24-hour wrist-worn accelerometer. ST was reported by parents by using reliable and valid items derived from the Health Behavior in School-aged Children (Chinese version). A series of binary logical regression analyses were performed for analysis. Results Only 16.2% met all the three movement behavior recommendations. The proportions of children with ASD who met the recommendation for PA, ST, and sleep were 32.3%, 52.5%, and 65.7%, respectively. The children with ASD who met the MVPA (OR = 0.37, 95% CI: 0.15-0.94), MVPA + Sleep (OR = 0.27, 95% CI: 0.09-0.81), and all three 24-hour movement guidelines (OR = 0.14, 95% CI: 0.03-0.77), had significantly lower odds ratios for overweight/obesity than those who did not meet the respective recommendations. Conclusions Meeting the MVPA, MVPA + Sleep, and all three of the guidelines was associated with lower odds ratios for overweight and obesity in children with ASD, and MVPA was the single most important activity for weight control among this population. Therefore, meeting the 24-hour movement guidelines, especially the MVPA guideline should be considered an effective intervention and can inform the design of strategies and policies for the prevention of overweight and obesity in children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Markers related to oxidative stress in peripheral blood in children with autism spectrum disorder / Xiaoping LIN in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102067 Titre : Markers related to oxidative stress in peripheral blood in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoping LIN, Auteur ; Yingyu ZHOU, Auteur ; Shaowen LI, Auteur ; Haohan ZHOU, Auteur ; Binjie MA, Auteur ; Zheqing ZHANG, Auteur ; Jingjing LIANG, Auteur Article en page(s) : 102067 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Oxidative stress  Vitamin A  Vitamin E  Mitochondrial DNA copy number  Telomere length Index. décimale : PER Périodiques Résumé : Background Oxidative stress in the brain contributes to neuronal damage in genetically susceptible children, which might be involved in the pathophysiology of autism spectrum disorder(ASD). However, clinical data were inconsistent. The goal of this study was to investigate whether oxidative stress markers (vitamin A and vitamin E concentrations and leukocyte mitochondrial DNA copy number and telomere length) in peripheral blood are related to ASD in Chinese children aged 6-9 years. Method Sixty seven individuals with ASD and 134 sex- and age-matched neurotypical controls participated. The relative mitochondrial DNA copy number (mtDNAcn) and telomere length of leukocytes in peripheral blood were measured using quantitative real-time polymerase chain reaction. The vitamin A and vitamin E concentrations in plasma were determined using reversed-phase high-performance liquid chromatography. Results ASD group had a higher leukocyte mtDNAcn (1.36 Â+ 0.49 vs. 1.03 Â+ 0.24, p < 0.001) and vitamin E concentration (5.79 Â+ 1.70 ng/ml vs. 5.30 Â+ 0.96 ng/ml, p = 0.044) than the control group, but no significant differences in vitamin A concentration and leukocyte telomere length were detected between groups. Leukocyte mtDNAcn in the highest tertile increased the risk of ASD by 4.259 times (odds ratio:4.259, 95% confidence interval: 1.427-12.707, p = 0.009) compared with the lowest tertile after adjustment for confounders, and a significant dose-response relationship between mtDNAcn and ASD risk was observed (p-trend = 0.032). Conclusions Children with ASD had higher levels of leukocyte mtDNAcn. En ligne : https://doi.org/10.1016/j.rasd.2022.102067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Markers related to oxidative stress in peripheral blood in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Xiaoping LIN, Auteur ; Yingyu ZHOU, Auteur ; Shaowen LI, Auteur ; Haohan ZHOU, Auteur ; Binjie MA, Auteur ; Zheqing ZHANG, Auteur ; Jingjing LIANG, Auteur . - 102067. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102067 Mots-clés : Autism spectrum disorders  Oxidative stress  Vitamin A  Vitamin E  Mitochondrial DNA copy number  Telomere length Index. décimale : PER Périodiques Résumé : Background Oxidative stress in the brain contributes to neuronal damage in genetically susceptible children, which might be involved in the pathophysiology of autism spectrum disorder(ASD). However, clinical data were inconsistent. The goal of this study was to investigate whether oxidative stress markers (vitamin A and vitamin E concentrations and leukocyte mitochondrial DNA copy number and telomere length) in peripheral blood are related to ASD in Chinese children aged 6-9 years. Method Sixty seven individuals with ASD and 134 sex- and age-matched neurotypical controls participated. The relative mitochondrial DNA copy number (mtDNAcn) and telomere length of leukocytes in peripheral blood were measured using quantitative real-time polymerase chain reaction. The vitamin A and vitamin E concentrations in plasma were determined using reversed-phase high-performance liquid chromatography. Results ASD group had a higher leukocyte mtDNAcn (1.36 Â+ 0.49 vs. 1.03 Â+ 0.24, p < 0.001) and vitamin E concentration (5.79 Â+ 1.70 ng/ml vs. 5.30 Â+ 0.96 ng/ml, p = 0.044) than the control group, but no significant differences in vitamin A concentration and leukocyte telomere length were detected between groups. Leukocyte mtDNAcn in the highest tertile increased the risk of ASD by 4.259 times (odds ratio:4.259, 95% confidence interval: 1.427-12.707, p = 0.009) compared with the lowest tertile after adjustment for confounders, and a significant dose-response relationship between mtDNAcn and ASD risk was observed (p-trend = 0.032). Conclusions Children with ASD had higher levels of leukocyte mtDNAcn. En ligne : https://doi.org/10.1016/j.rasd.2022.102067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Treatment of anxiety in autistic adults: A systematic review / Michelle MENEZES in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102068 Titre : Treatment of anxiety in autistic adults: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Michelle MENEZES, Auteur ; Christina HARKINS, Auteur ; Melissa F. ROBINSON, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Robert CROSS, Auteur ; Roma A. VASA, Auteur ; Micah O. MAZUREK, Auteur Article en page(s) : 102068 Langues : Anglais (eng) Mots-clés : Autism  ASD  Anxiety  Mental health  Treatment Index. décimale : PER Périodiques Résumé : Background Autistic adults are more likely than adults without autism spectrum disorder (ASD) to experience clinically significant anxiety. In addition, anxiety in autistic adults is associated with poorer quality of life and myriad negative outcomes (e.g., unemployment, suicidality). Therefore, this systematic review aimed to summarize and evaluate the literature on the psychotherapeutic and psychopharmacological treatment of anxiety in autistic adults to inform clinical decision-making. Method Several online databases were searched for peer-reviewed journal articles with any combination of the following terms in the abstract: (1) autism, autistic, Asperger, Asperger’s, or œpervasive developmental disorder � (2) anxiety, anxious, phobia, mutism, panic, agoraphobia, or worry and (3) treatment, intervention, trial, therapy, psychotherapy, pharmacotherapy, medication, drug, antidepressant, sedative, or anti-anxiety. Data were extracted from articles meeting the inclusion criteria, and the strength of the evidence was assessed for treatments. Results Fifteen psychosocial treatment studies, one pharmacological treatment study, and one combined psychosocial and pharmacological treatment study met the inclusion criteria. The most investigated treatment for anxiety in adults with ASD was cognitive behavioral therapy (CBT). Conclusions Few studies have investigated the treatment of anxiety in autistic adults. Additionally, findings have been inconsistent across studies regarding the potential effectiveness of particular psychosocial and pharmacological treatments. More research is certainly needed before clinically useful conclusions can be made. En ligne : https://doi.org/10.1016/j.rasd.2022.102068 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Treatment of anxiety in autistic adults: A systematic review [Texte imprimé et/ou numérique] / Michelle MENEZES, Auteur ; Christina HARKINS, Auteur ; Melissa F. ROBINSON, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Robert CROSS, Auteur ; Roma A. VASA, Auteur ; Micah O. MAZUREK, Auteur . - 102068. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102068 Mots-clés : Autism  ASD  Anxiety  Mental health  Treatment Index. décimale : PER Périodiques Résumé : Background Autistic adults are more likely than adults without autism spectrum disorder (ASD) to experience clinically significant anxiety. In addition, anxiety in autistic adults is associated with poorer quality of life and myriad negative outcomes (e.g., unemployment, suicidality). Therefore, this systematic review aimed to summarize and evaluate the literature on the psychotherapeutic and psychopharmacological treatment of anxiety in autistic adults to inform clinical decision-making. Method Several online databases were searched for peer-reviewed journal articles with any combination of the following terms in the abstract: (1) autism, autistic, Asperger, Asperger’s, or œpervasive developmental disorder � (2) anxiety, anxious, phobia, mutism, panic, agoraphobia, or worry and (3) treatment, intervention, trial, therapy, psychotherapy, pharmacotherapy, medication, drug, antidepressant, sedative, or anti-anxiety. Data were extracted from articles meeting the inclusion criteria, and the strength of the evidence was assessed for treatments. Results Fifteen psychosocial treatment studies, one pharmacological treatment study, and one combined psychosocial and pharmacological treatment study met the inclusion criteria. The most investigated treatment for anxiety in adults with ASD was cognitive behavioral therapy (CBT). Conclusions Few studies have investigated the treatment of anxiety in autistic adults. Additionally, findings have been inconsistent across studies regarding the potential effectiveness of particular psychosocial and pharmacological treatments. More research is certainly needed before clinically useful conclusions can be made. En ligne : https://doi.org/10.1016/j.rasd.2022.102068 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

“I want to fit in… but I don’t want to change myself fundamentally”: A qualitative exploration of the relationship between masking and mental health for autistic teenagers / Louise CHAPMAN in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102069 Titre : “I want to fit in… but I don’t want to change myself fundamentally”: A qualitative exploration of the relationship between masking and mental health for autistic teenagers Type de document : Texte imprimé et/ou numérique Auteurs : Louise CHAPMAN, Auteur ; Kieran ROSE, Auteur ; Laura HULL, Auteur ; William MANDY, Auteur Année de publication : 2022 Article en page(s) : 102069 Langues : Anglais (eng) Mots-clés : Autism  Masking  Authenticity  Mental health  Young people Index. décimale : PER Périodiques Résumé : Background Previous research has identified an association between masking and mental health for autistic people. However, the direction of causality and mechanisms involved in this relationship are not well understood. This qualitative study aimed to investigate autistic teenagers’ experiences of masking, mental health and how the two develop and interact. Methods Twenty autistic teenagers took part in a semi-structured interview. The interviews were analysed using Reflexive Thematic Analysis. Results From the analysis, one theme was identified to conceptualise masking as described by participants. Five more inter-related themes were identified, each involved both in the relationship between masking and mental health and conversely in the relationship between authenticity and mental health. Participants described how masking and mental health both influence each other, and both are influenced by social and environmental factors. Conclusions The findings are consistent with previous research indicating that masking is associated with mental health difficulties. Our analysis presents a broader conceptualisation of masking than previously defined in the literature, placing social oppression of autistic people at the heart of the relationship between masking and mental health. The findings have implications for diagnostic services, post-diagnostic support and therapeutic interventions, highlighting the need to challenge deficit-based narratives of autism. En ligne : https://doi.org/10.1016/j.rasd.2022.102069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] “I want to fit in… but I don’t want to change myself fundamentally”: A qualitative exploration of the relationship between masking and mental health for autistic teenagers [Texte imprimé et/ou numérique] / Louise CHAPMAN, Auteur ; Kieran ROSE, Auteur ; Laura HULL, Auteur ; William MANDY, Auteur . - 2022 . - 102069. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102069 Mots-clés : Autism  Masking  Authenticity  Mental health  Young people Index. décimale : PER Périodiques Résumé : Background Previous research has identified an association between masking and mental health for autistic people. However, the direction of causality and mechanisms involved in this relationship are not well understood. This qualitative study aimed to investigate autistic teenagers’ experiences of masking, mental health and how the two develop and interact. Methods Twenty autistic teenagers took part in a semi-structured interview. The interviews were analysed using Reflexive Thematic Analysis. Results From the analysis, one theme was identified to conceptualise masking as described by participants. Five more inter-related themes were identified, each involved both in the relationship between masking and mental health and conversely in the relationship between authenticity and mental health. Participants described how masking and mental health both influence each other, and both are influenced by social and environmental factors. Conclusions The findings are consistent with previous research indicating that masking is associated with mental health difficulties. Our analysis presents a broader conceptualisation of masking than previously defined in the literature, placing social oppression of autistic people at the heart of the relationship between masking and mental health. The findings have implications for diagnostic services, post-diagnostic support and therapeutic interventions, highlighting the need to challenge deficit-based narratives of autism. En ligne : https://doi.org/10.1016/j.rasd.2022.102069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Positive psychology in neurodiversity: An investigation of character strengths in autistic adults in the United Kingdom in a community setting / Alicja Sabina NOCON in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102071 Titre : Positive psychology in neurodiversity: An investigation of character strengths in autistic adults in the United Kingdom in a community setting Type de document : Texte imprimé et/ou numérique Auteurs : Alicja Sabina NOCON, Auteur ; Amanda ROESTORF, Auteur ; Luz Maria Gutiérrez MENÃNDEZ, Auteur Article en page(s) : 102071 Langues : Anglais (eng) Mots-clés : Autistic adults  Autism spectrum  Character strengths  Positive Psychology  Strengths-based Interventions  Satisfaction with Life Index. décimale : PER Périodiques Résumé : Background The positive psychology and neurodiversity movements both aim to promote and improve wellbeing through strengths-based approaches. However, little is known about how positive psychology can support the wellbeing of autistic people. The present study investigated character strengths profiles as a potential tool to identify strengths-based interventions that could enhance wellbeing outcomes for autistic adults. To our knowledge, this is first study to use this method as a possible way of improving the wellbeing of autistic adults in the community in the UK. Method Forty-seven self-reported formally diagnosed (83%) and self-identifying (17%) autistic adults completed online self-rated standardised questionnaires about their character strengths and life satisfaction. Descriptive statistics and correlational analyses were used to evaluate the profile of character strengths and their relationship to overall life satisfaction. Results Character strengths most frequently reported by autistic adults were Honesty, Appreciation of Beauty and Excellence, Love of Learning, Fairness, and Kindness. Higher levels of life satisfaction were associated with character strengths of Gratitude, Hope, and Honesty. Conclusions The most frequent character strengths were consistent with autistic traits reported in the wider body of autism literature, such as intense interests and strong attention to detail. The present study provides preliminary findings and recommendations for potential future strengths-based interventions that could enhance life satisfaction of autistic adults in a community setting. Further investigation with larger samples is needed to replicate the emerging findings on this topic. En ligne : https://doi.org/10.1016/j.rasd.2022.102071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Positive psychology in neurodiversity: An investigation of character strengths in autistic adults in the United Kingdom in a community setting [Texte imprimé et/ou numérique] / Alicja Sabina NOCON, Auteur ; Amanda ROESTORF, Auteur ; Luz Maria Gutiérrez MENÃNDEZ, Auteur . - 102071. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102071 Mots-clés : Autistic adults  Autism spectrum  Character strengths  Positive Psychology  Strengths-based Interventions  Satisfaction with Life Index. décimale : PER Périodiques Résumé : Background The positive psychology and neurodiversity movements both aim to promote and improve wellbeing through strengths-based approaches. However, little is known about how positive psychology can support the wellbeing of autistic people. The present study investigated character strengths profiles as a potential tool to identify strengths-based interventions that could enhance wellbeing outcomes for autistic adults. To our knowledge, this is first study to use this method as a possible way of improving the wellbeing of autistic adults in the community in the UK. Method Forty-seven self-reported formally diagnosed (83%) and self-identifying (17%) autistic adults completed online self-rated standardised questionnaires about their character strengths and life satisfaction. Descriptive statistics and correlational analyses were used to evaluate the profile of character strengths and their relationship to overall life satisfaction. Results Character strengths most frequently reported by autistic adults were Honesty, Appreciation of Beauty and Excellence, Love of Learning, Fairness, and Kindness. Higher levels of life satisfaction were associated with character strengths of Gratitude, Hope, and Honesty. Conclusions The most frequent character strengths were consistent with autistic traits reported in the wider body of autism literature, such as intense interests and strong attention to detail. The present study provides preliminary findings and recommendations for potential future strengths-based interventions that could enhance life satisfaction of autistic adults in a community setting. Further investigation with larger samples is needed to replicate the emerging findings on this topic. En ligne : https://doi.org/10.1016/j.rasd.2022.102071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491