Dépouillements

Building Capacity: A Systematic Review of Training in the Diagnosis of Autism for Community-Based Clinicians / Mya HOWARD ; Michelle MENEZES ; Christina BURROUGHS ; Jessica PAPPAGIANOPOULOS ; Vibha SASTRI ; Sophie BRUNT ; Ryan MILLER ; Anzhelika PARENCHUK ; Jocelyn KUHN ; Micah O. MAZUREK in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.690-709 Titre : Building Capacity: A Systematic Review of Training in the Diagnosis of Autism for Community-Based Clinicians Type de document : Texte imprimé et/ou numérique Auteurs : Mya HOWARD, Auteur ; Michelle MENEZES, Auteur ; Christina BURROUGHS, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Vibha SASTRI, Auteur ; Sophie BRUNT, Auteur ; Ryan MILLER, Auteur ; Anzhelika PARENCHUK, Auteur ; Jocelyn KUHN, Auteur ; Micah O. MAZUREK, Auteur Article en page(s) : p.690-709 Langues : Anglais (eng) Mots-clés : autism diagnosis  capacity-building  clinician training  diagnostic training  systematic review Index. décimale : PER Périodiques Résumé : ABSTRACT In an effort to reduce the ?waitlist crisis,? researchers have developed training programs to educate community-based clinicians in best-practice autism diagnostic assessments. This systematic review aims to synthesize the effectiveness and implementation outcomes of such trainings. The following databases were searched from inception until August 2023: PubMed, Web of Science, APA PsycINFO, CINAHL, ERIC, and a select number from Google Scholar. Ten studies were included in the present review because they met the following criteria: development and/or evaluation of a training for practicing community-based clinicians to diagnose autism, published full-text in English, and original research. Risk of bias was assessed through an adapted NIH quality assessment tool. Only seven distinct training programs in autism diagnosis for practicing community-based clinicians were identified. Trainings demonstrated preliminary efficacy in the improvement of clinician knowledge, self-efficacy, practice behavior, and diagnostic accuracy. Many of the trainings had a reported positive impact on the community and were feasible to participate in; however, systems-level factors (e.g., time and reimbursement) remain as barriers to community-based diagnosis. Findings from the present review position clinician training as a promising strategy to increase families' timely access to an autism diagnosis. More research on training models is needed due to both the limited number of trainings and the limited reported effectiveness and implementation outcomes. Future implementation studies are also needed to reduce systems-level barriers and to aid in the determination of what trainings best fit the needs of different contexts. En ligne : https://doi.org/10.1002/aur.70014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Building Capacity: A Systematic Review of Training in the Diagnosis of Autism for Community-Based Clinicians [Texte imprimé et/ou numérique] / Mya HOWARD, Auteur ; Michelle MENEZES, Auteur ; Christina BURROUGHS, Auteur ; Jessica PAPPAGIANOPOULOS, Auteur ; Vibha SASTRI, Auteur ; Sophie BRUNT, Auteur ; Ryan MILLER, Auteur ; Anzhelika PARENCHUK, Auteur ; Jocelyn KUHN, Auteur ; Micah O. MAZUREK, Auteur . - p.690-709. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.690-709 Mots-clés : autism diagnosis  capacity-building  clinician training  diagnostic training  systematic review Index. décimale : PER Périodiques Résumé : ABSTRACT In an effort to reduce the ?waitlist crisis,? researchers have developed training programs to educate community-based clinicians in best-practice autism diagnostic assessments. This systematic review aims to synthesize the effectiveness and implementation outcomes of such trainings. The following databases were searched from inception until August 2023: PubMed, Web of Science, APA PsycINFO, CINAHL, ERIC, and a select number from Google Scholar. Ten studies were included in the present review because they met the following criteria: development and/or evaluation of a training for practicing community-based clinicians to diagnose autism, published full-text in English, and original research. Risk of bias was assessed through an adapted NIH quality assessment tool. Only seven distinct training programs in autism diagnosis for practicing community-based clinicians were identified. Trainings demonstrated preliminary efficacy in the improvement of clinician knowledge, self-efficacy, practice behavior, and diagnostic accuracy. Many of the trainings had a reported positive impact on the community and were feasible to participate in; however, systems-level factors (e.g., time and reimbursement) remain as barriers to community-based diagnosis. Findings from the present review position clinician training as a promising strategy to increase families' timely access to an autism diagnosis. More research on training models is needed due to both the limited number of trainings and the limited reported effectiveness and implementation outcomes. Future implementation studies are also needed to reduce systems-level barriers and to aid in the determination of what trainings best fit the needs of different contexts. En ligne : https://doi.org/10.1002/aur.70014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Expanding Research on Contextual Factors in Autism Research: What Took Us So Long? / Teresa BENNETT ; Leann Smith DAWALT ; Maureen S. DURKIN ; Gordon FORBES ; Patricia HOWLIN ; Catherine LORD ; Anat ZAIDMAN-ZAIT ; Lonnie ZWAIGENBAUM ; Vanessa BAL ; Somer BISHOP ; Chung-Hsin CHIANG ; Adriana DIMARTINO ; Christine M. FREITAG ; Stelios GEORGIADES ; Matthew HOLLOCKS ; Meng-Chuan LAI ; Matthew J. MAENNER ; Patrick S. POWELL ; Julie Lounds TAYLOR ; Alycia HALLADAY in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.710-716 Titre : Expanding Research on Contextual Factors in Autism Research: What Took Us So Long? Type de document : Texte imprimé et/ou numérique Auteurs : Teresa BENNETT, Auteur ; Leann Smith DAWALT, Auteur ; Maureen S. DURKIN, Auteur ; Gordon FORBES, Auteur ; Patricia HOWLIN, Auteur ; Catherine LORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Vanessa BAL, Auteur ; Somer BISHOP, Auteur ; Chung-Hsin CHIANG, Auteur ; Adriana DIMARTINO, Auteur ; Christine M. FREITAG, Auteur ; Stelios GEORGIADES, Auteur ; Matthew HOLLOCKS, Auteur ; Meng-Chuan LAI, Auteur ; Matthew J. MAENNER, Auteur ; Patrick S. POWELL, Auteur ; Julie Lounds TAYLOR, Auteur ; Alycia HALLADAY, Auteur Article en page(s) : p.710-716 Langues : Anglais (eng) Mots-clés : autism  behavior  contextual  longitudinal  outcomes  research Index. décimale : PER Périodiques Résumé : ABSTRACT Although autism is a childhood-onset neurodevelopmental disorder, its features change across the life course due to a combination of individual and contextual influences. However, the influence of contextual factors on development during childhood and beyond is less frequently studied than individual factors such as genetic variants that increase autism risk, IQ, language, and autistic features. Potentially important contexts include the family environment and socioeconomic status, social networks, school, work, services, neighborhood characteristics, environmental events, and sociocultural factors. Here, we articulate the benefit of studying contextual factors, and we offer selected examples of published longitudinal autism studies that have focused on how individuals develop within context. Expanding the autism research agenda to include the broader context in which autism emerges and changes across the life course can enhance understanding of how contexts influence the heterogeneity of autism, support strengths and resilience, or amplify disabilities. We describe challenges and opportunities for future research on contextual influences and provide a list of digital resources that can be integrated into autism data sets. It is important to conceptualize contextual influences on autism development as main exposures, not only as descriptive variables or factors needing statistical control. En ligne : https://doi.org/10.1002/aur.3312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Expanding Research on Contextual Factors in Autism Research: What Took Us So Long? [Texte imprimé et/ou numérique] / Teresa BENNETT, Auteur ; Leann Smith DAWALT, Auteur ; Maureen S. DURKIN, Auteur ; Gordon FORBES, Auteur ; Patricia HOWLIN, Auteur ; Catherine LORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Vanessa BAL, Auteur ; Somer BISHOP, Auteur ; Chung-Hsin CHIANG, Auteur ; Adriana DIMARTINO, Auteur ; Christine M. FREITAG, Auteur ; Stelios GEORGIADES, Auteur ; Matthew HOLLOCKS, Auteur ; Meng-Chuan LAI, Auteur ; Matthew J. MAENNER, Auteur ; Patrick S. POWELL, Auteur ; Julie Lounds TAYLOR, Auteur ; Alycia HALLADAY, Auteur . - p.710-716. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.710-716 Mots-clés : autism  behavior  contextual  longitudinal  outcomes  research Index. décimale : PER Périodiques Résumé : ABSTRACT Although autism is a childhood-onset neurodevelopmental disorder, its features change across the life course due to a combination of individual and contextual influences. However, the influence of contextual factors on development during childhood and beyond is less frequently studied than individual factors such as genetic variants that increase autism risk, IQ, language, and autistic features. Potentially important contexts include the family environment and socioeconomic status, social networks, school, work, services, neighborhood characteristics, environmental events, and sociocultural factors. Here, we articulate the benefit of studying contextual factors, and we offer selected examples of published longitudinal autism studies that have focused on how individuals develop within context. Expanding the autism research agenda to include the broader context in which autism emerges and changes across the life course can enhance understanding of how contexts influence the heterogeneity of autism, support strengths and resilience, or amplify disabilities. We describe challenges and opportunities for future research on contextual influences and provide a list of digital resources that can be integrated into autism data sets. It is important to conceptualize contextual influences on autism development as main exposures, not only as descriptive variables or factors needing statistical control. En ligne : https://doi.org/10.1002/aur.3312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Identifying and Responding to Gaps in the Academic Research Pipeline: Findings From the International Society for Autism Research (INSAR) Early Career Committee / Giacomo VIVANTI ; Subhashini JAYANATH ; Kimberly CARPENTER ; Mark D. SHEN ; Frederick SHIC ; Jill LOCKE in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.717-724 Titre : Identifying and Responding to Gaps in the Academic Research Pipeline: Findings From the International Society for Autism Research (INSAR) Early Career Committee Type de document : Texte imprimé et/ou numérique Auteurs : Giacomo VIVANTI, Auteur ; Subhashini JAYANATH, Auteur ; Kimberly CARPENTER, Auteur ; Mark D. SHEN, Auteur ; Frederick SHIC, Auteur ; Jill LOCKE, Auteur Article en page(s) : p.717-724 Langues : Anglais (eng) Mots-clés : autism  career development  early career researcher  global training resources Index. décimale : PER Périodiques Résumé : ABSTRACT The International Society for Autism Research (INSAR) was established in 2001 with the purpose of providing researchers in the field of autism a specific venue to enhance the quality of multidisciplinary research and elevate the field among the sciences. The autism field and size of the society has now expanded greatly to include over 5000 members, 29% of whom identify as early career researchers. In 2016, a survey was conducted with these early career researchers to identify existing supports and areas of need necessary for a successful and sustained autism research career. Results clearly identified three areas of need: (1) networking opportunities with ?change makers,? including funding agencies, journal editors, and senior autism researchers; (2) ensuring early career researchers in the autism research field were diverse and representative of the world; and (3) support from senior researchers to help early career researchers secure their first independent grant and move through promotion. The INSAR Early Career Committee (ECC) was established and developed three initiatives to address the aforementioned gaps: Research Rapid Rounds, the Global Representatives Initiative Pilot (GRIP), and the Mentoring Initiative. The ECC has successfully connected over 34 early career researchers and 40 students/trainees to mentors in 19 unique countries through networking programs and events and has established representatives in seven different countries outside the US and UK. These initiatives are a step towards supporting early career academics in the autism field and bring together autism researchers from around the world to share their work and create professional collaborations to forge our field forward. En ligne : https://doi.org/10.1002/aur.70028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Identifying and Responding to Gaps in the Academic Research Pipeline: Findings From the International Society for Autism Research (INSAR) Early Career Committee [Texte imprimé et/ou numérique] / Giacomo VIVANTI, Auteur ; Subhashini JAYANATH, Auteur ; Kimberly CARPENTER, Auteur ; Mark D. SHEN, Auteur ; Frederick SHIC, Auteur ; Jill LOCKE, Auteur . - p.717-724. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.717-724 Mots-clés : autism  career development  early career researcher  global training resources Index. décimale : PER Périodiques Résumé : ABSTRACT The International Society for Autism Research (INSAR) was established in 2001 with the purpose of providing researchers in the field of autism a specific venue to enhance the quality of multidisciplinary research and elevate the field among the sciences. The autism field and size of the society has now expanded greatly to include over 5000 members, 29% of whom identify as early career researchers. In 2016, a survey was conducted with these early career researchers to identify existing supports and areas of need necessary for a successful and sustained autism research career. Results clearly identified three areas of need: (1) networking opportunities with ?change makers,? including funding agencies, journal editors, and senior autism researchers; (2) ensuring early career researchers in the autism research field were diverse and representative of the world; and (3) support from senior researchers to help early career researchers secure their first independent grant and move through promotion. The INSAR Early Career Committee (ECC) was established and developed three initiatives to address the aforementioned gaps: Research Rapid Rounds, the Global Representatives Initiative Pilot (GRIP), and the Mentoring Initiative. The ECC has successfully connected over 34 early career researchers and 40 students/trainees to mentors in 19 unique countries through networking programs and events and has established representatives in seven different countries outside the US and UK. These initiatives are a step towards supporting early career academics in the autism field and bring together autism researchers from around the world to share their work and create professional collaborations to forge our field forward. En ligne : https://doi.org/10.1002/aur.70028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults / Radek MARE?EK ; Rostislav STAN?K ; Calum HARTLEY ; Klaus KESSLER ; Pavlína HLAVATÁ ; Hana O?LEJ?KOVÁ ; Milan BRÁZDIL ; Daniel Joel SHAW in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.725-740 Titre : Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults Type de document : Texte imprimé et/ou numérique Auteurs : Radek MARE?EK, Auteur ; Rostislav STAN?K, Auteur ; Calum HARTLEY, Auteur ; Klaus KESSLER, Auteur ; Pavlína HLAVATÁ, Auteur ; Hana O?LEJ?KOVÁ, Auteur ; Milan BRÁZDIL, Auteur ; Daniel Joel SHAW, Auteur Article en page(s) : p.725-740 Langues : Anglais (eng) Mots-clés : autism  dynamic functional connectivity  reciprocity  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non-autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)?an interactive task that emulates the reciprocal characteristic of naturalistic interpersonal exchanges. Two age-matched sets of male?male dyads were investigated: 16 comprised an autistic Responder and a non-autistic Proposer, and 19 comprised non-autistic pairs of Responder and Proposer. Players' round-by-round behavior on the iUG was modeled as reciprocal choices, and dynamic functional connectivity (dFC) was measured to identify the neural mechanisms underpinning reciprocal behaviors. Behavioral expressions of reciprocity were significantly reduced in autistic compared with non-autistic Responders, yet no such differences were observed between the non-autistic Proposers in either set of dyads. Furthermore, we identified latent dFC states with temporal properties associated with reciprocity. Autistic interactants spent less time in brain states characterized by dynamic inter-network integration and segregation among the Default Mode Network and cognitive control networks, suggesting that their reduced expressions of social?emotional reciprocity reflect less efficient reconfigurations among brain networks supporting flexible cognition and behavior. These findings advance our mechanistic understanding of the social difficulties characterizing autism. En ligne : https://doi.org/10.1002/aur.70010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults [Texte imprimé et/ou numérique] / Radek MARE?EK, Auteur ; Rostislav STAN?K, Auteur ; Calum HARTLEY, Auteur ; Klaus KESSLER, Auteur ; Pavlína HLAVATÁ, Auteur ; Hana O?LEJ?KOVÁ, Auteur ; Milan BRÁZDIL, Auteur ; Daniel Joel SHAW, Auteur . - p.725-740. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.725-740 Mots-clés : autism  dynamic functional connectivity  reciprocity  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non-autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)?an interactive task that emulates the reciprocal characteristic of naturalistic interpersonal exchanges. Two age-matched sets of male?male dyads were investigated: 16 comprised an autistic Responder and a non-autistic Proposer, and 19 comprised non-autistic pairs of Responder and Proposer. Players' round-by-round behavior on the iUG was modeled as reciprocal choices, and dynamic functional connectivity (dFC) was measured to identify the neural mechanisms underpinning reciprocal behaviors. Behavioral expressions of reciprocity were significantly reduced in autistic compared with non-autistic Responders, yet no such differences were observed between the non-autistic Proposers in either set of dyads. Furthermore, we identified latent dFC states with temporal properties associated with reciprocity. Autistic interactants spent less time in brain states characterized by dynamic inter-network integration and segregation among the Default Mode Network and cognitive control networks, suggesting that their reduced expressions of social?emotional reciprocity reflect less efficient reconfigurations among brain networks supporting flexible cognition and behavior. These findings advance our mechanistic understanding of the social difficulties characterizing autism. En ligne : https://doi.org/10.1002/aur.70010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder / Chao CHE ; Dong LI ; Xiaoli LI ; Xiaoxiao YU ; Lianhu YU ; Qin SUN ; Yaofang NIU ; Aihua Cao in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.741-751 Titre : Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chao CHE, Auteur ; Dong LI, Auteur ; Xiaoli LI, Auteur ; Xiaoxiao YU, Auteur ; Lianhu YU, Auteur ; Qin SUN, Auteur ; Yaofang NIU, Auteur ; Aihua Cao, Auteur Article en page(s) : p.741-751 Langues : Anglais (eng) Mots-clés : 16S rRNA sequencing  attention deficit hyperactivity disorder  autism spectrum disorder  gut microbiota  metabolic functions Index. décimale : PER Périodiques Résumé : ABSTRACT The potential etiological and diagnostic values of the gut microbiota in children with neurodevelopmental disorders are encouraging but controversial. In particular, the composition and characteristics of the gut microbiota in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) remain largely unidentified. Herein, we analyzed stool samples from 113 participants with a clinical diagnosis of ASD, 43 with ADHD, 8 with both ASD and ADHD, and 120 healthy controls between 2 and 11?years of age using 16S rRNA sequencing. We observed that clinical diagnosis, age, comorbidities, food sensitivities, and antibiotic use significantly affected the gut microbiota. The enriched genera in the control group were relatively common and dominant human gut bacteria, such as Bacteroides, Faecalibacterium, and Roseburia. The genera present in children with neurodevelopmental disorders showed greater heterogeneity, and the abundance of Bifidobacterium was consistently increased. We found 4899 deregulated microbial metabolic functions and revealed the formation of a divergent genus-level network in patients. This analysis demonstrated that the gut microbial signatures efficiently discriminated patients from healthy participants in both the discovery (area under the curve [AUC]: 0.95?0.98) and validation (AUC: 0.69?0.74) sets. Importantly, although ASD and ADHD share several gut microbial characteristics, specific bacteria that contribute to the disease pathogenesis may have different metabolic functions. En ligne : https://doi.org/10.1002/aur.70016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder [Texte imprimé et/ou numérique] / Chao CHE, Auteur ; Dong LI, Auteur ; Xiaoli LI, Auteur ; Xiaoxiao YU, Auteur ; Lianhu YU, Auteur ; Qin SUN, Auteur ; Yaofang NIU, Auteur ; Aihua Cao, Auteur . - p.741-751. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.741-751 Mots-clés : 16S rRNA sequencing  attention deficit hyperactivity disorder  autism spectrum disorder  gut microbiota  metabolic functions Index. décimale : PER Périodiques Résumé : ABSTRACT The potential etiological and diagnostic values of the gut microbiota in children with neurodevelopmental disorders are encouraging but controversial. In particular, the composition and characteristics of the gut microbiota in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) remain largely unidentified. Herein, we analyzed stool samples from 113 participants with a clinical diagnosis of ASD, 43 with ADHD, 8 with both ASD and ADHD, and 120 healthy controls between 2 and 11?years of age using 16S rRNA sequencing. We observed that clinical diagnosis, age, comorbidities, food sensitivities, and antibiotic use significantly affected the gut microbiota. The enriched genera in the control group were relatively common and dominant human gut bacteria, such as Bacteroides, Faecalibacterium, and Roseburia. The genera present in children with neurodevelopmental disorders showed greater heterogeneity, and the abundance of Bifidobacterium was consistently increased. We found 4899 deregulated microbial metabolic functions and revealed the formation of a divergent genus-level network in patients. This analysis demonstrated that the gut microbial signatures efficiently discriminated patients from healthy participants in both the discovery (area under the curve [AUC]: 0.95?0.98) and validation (AUC: 0.69?0.74) sets. Importantly, although ASD and ADHD share several gut microbial characteristics, specific bacteria that contribute to the disease pathogenesis may have different metabolic functions. En ligne : https://doi.org/10.1002/aur.70016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder / Jingying WANG ; Desirae J. SHIRLEY ; Hanna M. GEMMELL ; Danielle CHRISTENSEN ; Ann-Marie ORLANDO ; Regilda A. ROMERO ; Brandon A. ZIELINSKI ; Zheng WANG in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.752-764 Titre : Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jingying WANG, Auteur ; Desirae J. SHIRLEY, Auteur ; Hanna M. GEMMELL, Auteur ; Danielle CHRISTENSEN, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; Brandon A. ZIELINSKI, Auteur ; Zheng WANG, Auteur Article en page(s) : p.752-764 Langues : Anglais (eng) Mots-clés : aging  autism spectrum disorder  dynamic postural sway  middle aged and older  postural control  static stance Index. décimale : PER Périodiques Résumé : ABSTRACT Postural control deviations remain largely unexplored in middle aged and older autistic adults. With the increased prevalence of neurodegenerative conditions and heightened fall risk, precise quantification of postural variability and coordination may provide valuable insights into aging associated neuromotor deviations in autistic adults. Forty-seven autistic and 48 non-autistic individuals completed static stance, anterior?posterior (AP), and mediolateral (ML) postural sway on a force platform. Center of pressure (COP) metrics were derived and interpreted using ANCOVAs for between-group comparisons and multilinear regressions for group? ? ?age interaction. Correlations between clinical measures and COP variables that differentiated groups were explored. Compared to non-autistic individuals, autistic adults exhibited greater COP standard deviation (COPSD) and COP trajectory length during static stance and demonstrated significant COPSD-AP reductions in older age. Autistic adults also exhibited decreased COP range of motion (ROM) but increased ROM variability in the target direction during dynamic stance. Autistic adults' postural sway was jerkier during dynamic stance, and increased ROM variability during dynamic AP sway was moderately associated with lower verbal IQ in autistic adults. Our findings highlight persistent postural control deviations in middle aged and older autistic adults. Static and dynamic stance are differentially associated with unique profiles of postural control in ASD. Specifically, autistic adults demonstrated pronounced increases in postural sway variability during static stance, while reducing coordination during dynamic conditions. The extent to which postural control deviations found in autistic adults are predictive to the onset of neurodegenerative conditions and the severity of falls warrants future longitudinal research. En ligne : https://doi.org/10.1002/aur.70024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jingying WANG, Auteur ; Desirae J. SHIRLEY, Auteur ; Hanna M. GEMMELL, Auteur ; Danielle CHRISTENSEN, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; Brandon A. ZIELINSKI, Auteur ; Zheng WANG, Auteur . - p.752-764. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.752-764 Mots-clés : aging  autism spectrum disorder  dynamic postural sway  middle aged and older  postural control  static stance Index. décimale : PER Périodiques Résumé : ABSTRACT Postural control deviations remain largely unexplored in middle aged and older autistic adults. With the increased prevalence of neurodegenerative conditions and heightened fall risk, precise quantification of postural variability and coordination may provide valuable insights into aging associated neuromotor deviations in autistic adults. Forty-seven autistic and 48 non-autistic individuals completed static stance, anterior?posterior (AP), and mediolateral (ML) postural sway on a force platform. Center of pressure (COP) metrics were derived and interpreted using ANCOVAs for between-group comparisons and multilinear regressions for group? ? ?age interaction. Correlations between clinical measures and COP variables that differentiated groups were explored. Compared to non-autistic individuals, autistic adults exhibited greater COP standard deviation (COPSD) and COP trajectory length during static stance and demonstrated significant COPSD-AP reductions in older age. Autistic adults also exhibited decreased COP range of motion (ROM) but increased ROM variability in the target direction during dynamic stance. Autistic adults' postural sway was jerkier during dynamic stance, and increased ROM variability during dynamic AP sway was moderately associated with lower verbal IQ in autistic adults. Our findings highlight persistent postural control deviations in middle aged and older autistic adults. Static and dynamic stance are differentially associated with unique profiles of postural control in ASD. Specifically, autistic adults demonstrated pronounced increases in postural sway variability during static stance, while reducing coordination during dynamic conditions. The extent to which postural control deviations found in autistic adults are predictive to the onset of neurodegenerative conditions and the severity of falls warrants future longitudinal research. En ligne : https://doi.org/10.1002/aur.70024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Atypical Developmental Patterns of Sensorimotor-Related Networks in Autism Spectrum Disorder: A BrainAGE Study Based on Resting-State fMRI / Chunying LU ; Min LI ; Bowen LI ; Xing SHANG ; Guifen JIAN ; Qianyue ZHANG ; Xue CHEN ; Xuan CAO ; Bifang HE ; Jia WANG ; Heng LIU ; Heng CHEN in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.765-773 Titre : Atypical Developmental Patterns of Sensorimotor-Related Networks in Autism Spectrum Disorder: A BrainAGE Study Based on Resting-State fMRI Type de document : Texte imprimé et/ou numérique Auteurs : Chunying LU, Auteur ; Min LI, Auteur ; Bowen LI, Auteur ; Xing SHANG, Auteur ; Guifen JIAN, Auteur ; Qianyue ZHANG, Auteur ; Xue CHEN, Auteur ; Xuan CAO, Auteur ; Bifang HE, Auteur ; Jia WANG, Auteur ; Heng LIU, Auteur ; Heng CHEN, Auteur Article en page(s) : p.765-773 Langues : Anglais (eng) Mots-clés : amplitude of low-frequency fluctuation  autism spectrum disorder  BrainAGE  resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder characterized by atypical brain development. Previous whole-brain BrainAGE studies have unveiled the presence of accelerated or delayed brain function developmental patterns in individuals with ASD. However, it remains unclear whether these patterns manifest at a global level throughout the entire brain or are specific to certain functional sub-networks. The study included resting-state functional magnetic resonance imaging (fMRI) data from 127 individuals with ASD and 135 healthy controls (aged between 5 and 40?years). ALFF maps were measured for each participant. Then, sub-network-level BrainAGE analyses were conducted across 10 sub-networks using the Individual-weighted Multilayer Perceptron Network (ILWMLP) regression method. The BrainAGE analyses revealed atypical developmental trajectories in sensorimotor-related sub-networks, encompassing auditory, motor, and sensorimotor sub-networks. In individuals with ASD, delayed brain function development was observed in the auditory and sensorimotor networks, with a more pronounced delay observed in older individuals. Conversely, the motor network exhibited accelerated development in younger individuals but delayed development in older individuals. Our findings unveiled aberrant developmental patterns in sensorimotor-related sub-networks among individuals with ASD, exhibiting distinct atypical profiles across different sub-networks. These results might contribute to a deeper understanding of the deviant brain development observed in ASD. En ligne : https://doi.org/10.1002/aur.70008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Atypical Developmental Patterns of Sensorimotor-Related Networks in Autism Spectrum Disorder: A BrainAGE Study Based on Resting-State fMRI [Texte imprimé et/ou numérique] / Chunying LU, Auteur ; Min LI, Auteur ; Bowen LI, Auteur ; Xing SHANG, Auteur ; Guifen JIAN, Auteur ; Qianyue ZHANG, Auteur ; Xue CHEN, Auteur ; Xuan CAO, Auteur ; Bifang HE, Auteur ; Jia WANG, Auteur ; Heng LIU, Auteur ; Heng CHEN, Auteur . - p.765-773. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.765-773 Mots-clés : amplitude of low-frequency fluctuation  autism spectrum disorder  BrainAGE  resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder characterized by atypical brain development. Previous whole-brain BrainAGE studies have unveiled the presence of accelerated or delayed brain function developmental patterns in individuals with ASD. However, it remains unclear whether these patterns manifest at a global level throughout the entire brain or are specific to certain functional sub-networks. The study included resting-state functional magnetic resonance imaging (fMRI) data from 127 individuals with ASD and 135 healthy controls (aged between 5 and 40?years). ALFF maps were measured for each participant. Then, sub-network-level BrainAGE analyses were conducted across 10 sub-networks using the Individual-weighted Multilayer Perceptron Network (ILWMLP) regression method. The BrainAGE analyses revealed atypical developmental trajectories in sensorimotor-related sub-networks, encompassing auditory, motor, and sensorimotor sub-networks. In individuals with ASD, delayed brain function development was observed in the auditory and sensorimotor networks, with a more pronounced delay observed in older individuals. Conversely, the motor network exhibited accelerated development in younger individuals but delayed development in older individuals. Our findings unveiled aberrant developmental patterns in sensorimotor-related sub-networks among individuals with ASD, exhibiting distinct atypical profiles across different sub-networks. These results might contribute to a deeper understanding of the deviant brain development observed in ASD. En ligne : https://doi.org/10.1002/aur.70008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Camera Movement Impacts on Mu-Wave Activity During Action Observation in Adults With Autism Spectrum Disorders Without Intellectual Disabilities / Renata DEL GIUDICE ; Francesca SERIO ; Giovanni BOIDO ; Gianmarco INGROSSO ; Francesco LOMBARDI ; Claudio SANGUINETI ; Valeria CASULA ; Adelaide BACCARA ; Elia CHIUDINELLI ; Francesca VAIRANO ; Federica Maria PANZERI ; Mauro GIORI ; Paolo Maria INGHILLERI DI VILLADAURO ; Raffaella FAGGIOLI ; Orsola GAMBINI ; Tomaso SUBINI ; Benedetta DEMARTINI in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.774-787 Titre : Camera Movement Impacts on Mu-Wave Activity During Action Observation in Adults With Autism Spectrum Disorders Without Intellectual Disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Renata DEL GIUDICE, Auteur ; Francesca SERIO, Auteur ; Giovanni BOIDO, Auteur ; Gianmarco INGROSSO, Auteur ; Francesco LOMBARDI, Auteur ; Claudio SANGUINETI, Auteur ; Valeria CASULA, Auteur ; Adelaide BACCARA, Auteur ; Elia CHIUDINELLI, Auteur ; Francesca VAIRANO, Auteur ; Federica Maria PANZERI, Auteur ; Mauro GIORI, Auteur ; Paolo Maria INGHILLERI DI VILLADAURO, Auteur ; Raffaella FAGGIOLI, Auteur ; Orsola GAMBINI, Auteur ; Tomaso SUBINI, Auteur ; Benedetta DEMARTINI, Auteur Article en page(s) : p.774-787 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  EEG  Mirror neuron system  mu-wave  perspective-taking Index. décimale : PER Périodiques Résumé : ABSTRACT The aim of this study was to investigate differences in mu-wave modulation in individuals diagnosed with autism spectrum disorder (ASD) without intellectual disabilities compared to a group of neurotypical controls (NT). Thirty autistic individuals and 30 NT underwent an EEG recording while watching short videos depicting goal-oriented action filmed from a fixed position, zooming in on the scene, and approaching the scene by means of a steadycam. Then, participants underwent a rating task to evaluate their subjective viewing experience. We found that steadycam videos elicited enhanced event-related desynchronization (ERD), suggestive of enhanced neural activity, in the NT group, and a reduced ERD in the autistic group, compared to the other filming conditions. Autistic participants also showed difficulties in returning to baseline mu-power levels after watching videos filmed from a fixed position. Finally, NT reported feeling more comfortable watching videos with movement, whereas autistic participants did not exhibit differences between conditions. We speculated that static, less naturalistic stimuli might impose higher and prolonged cognitive demands on autistic individuals. Understanding these differences might help develop tailored interventions to support perceptual, cognitive, and social processes of autistic people. En ligne : https://doi.org/10.1002/aur.70012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Camera Movement Impacts on Mu-Wave Activity During Action Observation in Adults With Autism Spectrum Disorders Without Intellectual Disabilities [Texte imprimé et/ou numérique] / Renata DEL GIUDICE, Auteur ; Francesca SERIO, Auteur ; Giovanni BOIDO, Auteur ; Gianmarco INGROSSO, Auteur ; Francesco LOMBARDI, Auteur ; Claudio SANGUINETI, Auteur ; Valeria CASULA, Auteur ; Adelaide BACCARA, Auteur ; Elia CHIUDINELLI, Auteur ; Francesca VAIRANO, Auteur ; Federica Maria PANZERI, Auteur ; Mauro GIORI, Auteur ; Paolo Maria INGHILLERI DI VILLADAURO, Auteur ; Raffaella FAGGIOLI, Auteur ; Orsola GAMBINI, Auteur ; Tomaso SUBINI, Auteur ; Benedetta DEMARTINI, Auteur . - p.774-787. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.774-787 Mots-clés : autism spectrum disorders  EEG  Mirror neuron system  mu-wave  perspective-taking Index. décimale : PER Périodiques Résumé : ABSTRACT The aim of this study was to investigate differences in mu-wave modulation in individuals diagnosed with autism spectrum disorder (ASD) without intellectual disabilities compared to a group of neurotypical controls (NT). Thirty autistic individuals and 30 NT underwent an EEG recording while watching short videos depicting goal-oriented action filmed from a fixed position, zooming in on the scene, and approaching the scene by means of a steadycam. Then, participants underwent a rating task to evaluate their subjective viewing experience. We found that steadycam videos elicited enhanced event-related desynchronization (ERD), suggestive of enhanced neural activity, in the NT group, and a reduced ERD in the autistic group, compared to the other filming conditions. Autistic participants also showed difficulties in returning to baseline mu-power levels after watching videos filmed from a fixed position. Finally, NT reported feeling more comfortable watching videos with movement, whereas autistic participants did not exhibit differences between conditions. We speculated that static, less naturalistic stimuli might impose higher and prolonged cognitive demands on autistic individuals. Understanding these differences might help develop tailored interventions to support perceptual, cognitive, and social processes of autistic people. En ligne : https://doi.org/10.1002/aur.70012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Waiting Times and Influencing Factors in Children and Adults Undergoing Assessment for Autism, ADHD, and Other Neurodevelopmental Differences / Anusua Singh ROY ; Lorna JOHNSTON ; Marie BOILSON ; Eleanor CURNOW ; Victoria JOHNSTONE-COOKE ; Marion RUTHERFORD in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.788-801 Titre : Waiting Times and Influencing Factors in Children and Adults Undergoing Assessment for Autism, ADHD, and Other Neurodevelopmental Differences Type de document : Texte imprimé et/ou numérique Auteurs : Anusua Singh ROY, Auteur ; Lorna JOHNSTON, Auteur ; Marie BOILSON, Auteur ; Eleanor CURNOW, Auteur ; Victoria JOHNSTONE-COOKE, Auteur ; Marion RUTHERFORD, Auteur Article en page(s) : p.788-801 Langues : Anglais (eng) Mots-clés : assessment  autism  diagnosis  neurodevelopmental  pathway Index. décimale : PER Périodiques Résumé : ABSTRACT This study explored waiting times and the factors influencing them in child and adult populations undergoing assessment for autism, ADHD, and other neurodevelopmental differences. The analysis focused on a retrospective review of 408 cases with assessments completed between October 2021 and May 2022, conducted by 30 diagnosing teams in Scotland. Data included age, final diagnosis, demographics, medical and developmental history, contact frequency, and assessment service adherence to best-practice standards. Waiting times were calculated, and relationships were analyzed using linear regression. Median waiting times were 525?days (IQR 329?857) for children/adolescents and 252?days (IQR 106?611) for adults. Only 20% of children's and 47% of adult assessments met the proposed 252-day diagnostic time target. Autism and ADHD were the most common diagnoses. Receiving >?1 neurodevelopmental diagnosis on completion was uncommon. Demographic factors did not significantly affect waiting times. Children/adolescents with more complex developmental and medical histories experienced longer waits (100.3?weeks vs. 67.7?weeks; p? En ligne : https://doi.org/10.1002/aur.70011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Waiting Times and Influencing Factors in Children and Adults Undergoing Assessment for Autism, ADHD, and Other Neurodevelopmental Differences [Texte imprimé et/ou numérique] / Anusua Singh ROY, Auteur ; Lorna JOHNSTON, Auteur ; Marie BOILSON, Auteur ; Eleanor CURNOW, Auteur ; Victoria JOHNSTONE-COOKE, Auteur ; Marion RUTHERFORD, Auteur . - p.788-801. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.788-801 Mots-clés : assessment  autism  diagnosis  neurodevelopmental  pathway Index. décimale : PER Périodiques Résumé : ABSTRACT This study explored waiting times and the factors influencing them in child and adult populations undergoing assessment for autism, ADHD, and other neurodevelopmental differences. The analysis focused on a retrospective review of 408 cases with assessments completed between October 2021 and May 2022, conducted by 30 diagnosing teams in Scotland. Data included age, final diagnosis, demographics, medical and developmental history, contact frequency, and assessment service adherence to best-practice standards. Waiting times were calculated, and relationships were analyzed using linear regression. Median waiting times were 525?days (IQR 329?857) for children/adolescents and 252?days (IQR 106?611) for adults. Only 20% of children's and 47% of adult assessments met the proposed 252-day diagnostic time target. Autism and ADHD were the most common diagnoses. Receiving >?1 neurodevelopmental diagnosis on completion was uncommon. Demographic factors did not significantly affect waiting times. Children/adolescents with more complex developmental and medical histories experienced longer waits (100.3?weeks vs. 67.7?weeks; p? En ligne : https://doi.org/10.1002/aur.70011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Slow but Steady: Similarities and Differences in Executive Functioning Between Autistic and Non-Autistic Adults / Sander BEGEER ; Hilde M. GEURTS ; Bhismadev CHAKRABARTI ; Erik VAN DER BURG in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.802-819 Titre : Slow but Steady: Similarities and Differences in Executive Functioning Between Autistic and Non-Autistic Adults Type de document : Texte imprimé et/ou numérique Auteurs : Sander BEGEER, Auteur ; Hilde M. GEURTS, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Erik VAN DER BURG, Auteur Article en page(s) : p.802-819 Langues : Anglais (eng) Mots-clés : ADHD  attentional orienting  autism  cognitive flexibility  executive function  inhibition  working memory Index. décimale : PER Périodiques Résumé : ABSTRACT Prior research has established differences between autistic and non-autistic individuals across the domains of executive function (EF). While some early theories portrayed these differences as universal to the autism spectrum, recent findings have been quite mixed. Factors like small samples, the components of EF being measured, and the age and intelligence quotient (IQ) of those being compared may contribute to this diversity in results. Moreover, research suggests performance over time might fluctuate in different patterns for autistic and non-autistic individuals. To test EF differences and the possible influence of these factors upon them, we recruited a sample of over 900 autistic and non-autistic participants (with generally average/above average IQ levels) from 18 to 77?years of age. They completed a battery of tasks measuring inhibition, cognitive flexibility, working memory, and attentional orienting to social and nonsocial cues. We found that performance was similar between groups in our primary measures of EF, although autistic participants were consistently slower, more susceptible to the effects of spatial cueing, and more prone to certain errors in the working memory task. Differences between groups were generally not influenced by participants' age, gender, or IQ. Performance over time varied only in the working memory task. While autistic adults may still face related challenges in real life, these findings suggest that being autistic does not necessarily imply executive dysfunction on a basic cognitive level, contradicting theories assuming universal impairments therein. Moreover, the lack of influence of included demographic factors suggests that explanations for discrepancies in the literature lie elsewhere. En ligne : https://doi.org/10.1002/aur.70015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Slow but Steady: Similarities and Differences in Executive Functioning Between Autistic and Non-Autistic Adults [Texte imprimé et/ou numérique] / Sander BEGEER, Auteur ; Hilde M. GEURTS, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Erik VAN DER BURG, Auteur . - p.802-819. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.802-819 Mots-clés : ADHD  attentional orienting  autism  cognitive flexibility  executive function  inhibition  working memory Index. décimale : PER Périodiques Résumé : ABSTRACT Prior research has established differences between autistic and non-autistic individuals across the domains of executive function (EF). While some early theories portrayed these differences as universal to the autism spectrum, recent findings have been quite mixed. Factors like small samples, the components of EF being measured, and the age and intelligence quotient (IQ) of those being compared may contribute to this diversity in results. Moreover, research suggests performance over time might fluctuate in different patterns for autistic and non-autistic individuals. To test EF differences and the possible influence of these factors upon them, we recruited a sample of over 900 autistic and non-autistic participants (with generally average/above average IQ levels) from 18 to 77?years of age. They completed a battery of tasks measuring inhibition, cognitive flexibility, working memory, and attentional orienting to social and nonsocial cues. We found that performance was similar between groups in our primary measures of EF, although autistic participants were consistently slower, more susceptible to the effects of spatial cueing, and more prone to certain errors in the working memory task. Differences between groups were generally not influenced by participants' age, gender, or IQ. Performance over time varied only in the working memory task. While autistic adults may still face related challenges in real life, these findings suggest that being autistic does not necessarily imply executive dysfunction on a basic cognitive level, contradicting theories assuming universal impairments therein. Moreover, the lack of influence of included demographic factors suggests that explanations for discrepancies in the literature lie elsewhere. En ligne : https://doi.org/10.1002/aur.70015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Sex-Differential Trajectories of Domain-Specific Associations Between Autistic Traits and Co-Occurring Emotional-Behavioral Concerns in Autistic Children / Thomas W. FRAZIER ; Peter SZATMARI ; Eric DUKU ; Annie E. RICHARD ; Isabel M. SMITH ; Lonnie ZWAIGENBAUM ; Rachael BEDFORD ; Connor M. KERNS ; Anat ZAIDMAN-ZAIT ; Terry BENNETT ; Mayada ELSABBAGH ; Tracy VAILLANCOURT ; Stelios GEORGIADES in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.820-832 Titre : Sex-Differential Trajectories of Domain-Specific Associations Between Autistic Traits and Co-Occurring Emotional-Behavioral Concerns in Autistic Children Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Peter SZATMARI, Auteur ; Eric DUKU, Auteur ; Annie E. RICHARD, Auteur ; Isabel M. SMITH, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Rachael BEDFORD, Auteur ; Connor M. KERNS, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Terry BENNETT, Auteur ; Mayada ELSABBAGH, Auteur ; Tracy VAILLANCOURT, Auteur ; Stelios GEORGIADES, Auteur Article en page(s) : p.820-832 Langues : Anglais (eng) Mots-clés : autism  co-occurring emotional/behavioral concerns  longitudinal  measurement invariance  time-varying associations Index. décimale : PER Périodiques Résumé : ABSTRACT Assessing autistic traits alongside co-occurring emotional/behavioral concerns (EBCs) is challenging due to their overlap in clinical presentations, which can vary by age and sex. This study aimed to investigate domain-specific associations between autistic traits and EBCs?including anxiety, affective, attention-deficit/hyperactivity, and oppositional-defiant problems?across childhood in autistic boys and girls. We prospectively followed 389 children (84% male) diagnosed with autism at ages 2?5?years, using the Social Responsiveness Scale (SRS) and Child Behavior Checklist (CBCL) across eight timepoints until age 12. Moderated nonlinear factor analysis was used to identify and adjust for measurement non-invariance of SRS items by age, sex, and EBCs. The adjusted scores were then used for sex-moderated time-varying modeling of associations between autistic traits and EBCs. Several SRS items in the domains of social-interaction difficulties and repetitive mannerisms showed significant intercept bias by age and level of co-occurring anxiety and ADHD (effect size r?>?0.20). In autistic boys, strong associations were observed between social-communication difficulties and EBCs around ages 7?9, which tended to diminish in late childhood. In contrast, autistic girls showed stable or intensifying associations, particularly with anxiety, into late childhood. Results revealed significant associations between autistic traits and EBCs after addressing item-level measurement biases. The varying associations over time highlight the importance of continuous monitoring to promptly address autistic children's sex-differential mental health needs. These findings emphasize the benefits of refining behavioral constructs and adopting a nuanced developmental approach to identify critical periods of symptom coupling/decoupling for informing evaluation and service provision. En ligne : https://doi.org/10.1002/aur.70018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Sex-Differential Trajectories of Domain-Specific Associations Between Autistic Traits and Co-Occurring Emotional-Behavioral Concerns in Autistic Children [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Peter SZATMARI, Auteur ; Eric DUKU, Auteur ; Annie E. RICHARD, Auteur ; Isabel M. SMITH, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Rachael BEDFORD, Auteur ; Connor M. KERNS, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Terry BENNETT, Auteur ; Mayada ELSABBAGH, Auteur ; Tracy VAILLANCOURT, Auteur ; Stelios GEORGIADES, Auteur . - p.820-832. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.820-832 Mots-clés : autism  co-occurring emotional/behavioral concerns  longitudinal  measurement invariance  time-varying associations Index. décimale : PER Périodiques Résumé : ABSTRACT Assessing autistic traits alongside co-occurring emotional/behavioral concerns (EBCs) is challenging due to their overlap in clinical presentations, which can vary by age and sex. This study aimed to investigate domain-specific associations between autistic traits and EBCs?including anxiety, affective, attention-deficit/hyperactivity, and oppositional-defiant problems?across childhood in autistic boys and girls. We prospectively followed 389 children (84% male) diagnosed with autism at ages 2?5?years, using the Social Responsiveness Scale (SRS) and Child Behavior Checklist (CBCL) across eight timepoints until age 12. Moderated nonlinear factor analysis was used to identify and adjust for measurement non-invariance of SRS items by age, sex, and EBCs. The adjusted scores were then used for sex-moderated time-varying modeling of associations between autistic traits and EBCs. Several SRS items in the domains of social-interaction difficulties and repetitive mannerisms showed significant intercept bias by age and level of co-occurring anxiety and ADHD (effect size r?>?0.20). In autistic boys, strong associations were observed between social-communication difficulties and EBCs around ages 7?9, which tended to diminish in late childhood. In contrast, autistic girls showed stable or intensifying associations, particularly with anxiety, into late childhood. Results revealed significant associations between autistic traits and EBCs after addressing item-level measurement biases. The varying associations over time highlight the importance of continuous monitoring to promptly address autistic children's sex-differential mental health needs. These findings emphasize the benefits of refining behavioral constructs and adopting a nuanced developmental approach to identify critical periods of symptom coupling/decoupling for informing evaluation and service provision. En ligne : https://doi.org/10.1002/aur.70018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Semi-Automated Multi-Label Classification of Autistic Mannerisms by Machine Learning on Post Hoc Skeletal Tracking / Solvejg K. KLEBER ; Leonie POLZER ; Naisan RAJI ; Janina KITZEROW-CLEVEN ; Ziyon KIM ; Simeon PLATTE ; Christine M. FREITAG ; Nico BAST in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.833-844 Titre : Semi-Automated Multi-Label Classification of Autistic Mannerisms by Machine Learning on Post Hoc Skeletal Tracking Type de document : Texte imprimé et/ou numérique Auteurs : Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Naisan RAJI, Auteur ; Janina KITZEROW-CLEVEN, Auteur ; Ziyon KIM, Auteur ; Simeon PLATTE, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur Article en page(s) : p.833-844 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  machine learning  mannerisms  multi-label classification  stereotypic behavior Index. décimale : PER Périodiques Résumé : ABSTRACT Mannerisms describe repetitive or unconventional body movements like arm flapping. These movements are early markers of restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD). However, assessing mannerisms reliably is challenging. Even after extensive training in behavioral observations, inter-rater agreements for mannerism items remain insufficient. The current study used machine learning (ML) to classify mannerisms from videotaped behavioral observations in children with ASD. We developed a classification scheme for mannerisms as ground truth and applied it to videotaped behavioral observations from an early intervention study. ML was used in two steps: First, the OpenPose algorithm post hoc extracted features based on body movements in the videos. Second, a long short-term memory (LSTM) neural network classified the features in a multi-label approach to distinguish between the absence of mannerisms, flapping, jumping, and both flapping + jumping. The trained models achieved 70.2% accuracy (F1 score: 31.8%) using nested cross-validation. The analysis improves on previous videotaped ML classification studies by splitting training and test data subject-wise, highlighting its clinical applicability. The LSTM models are made publicly available for use with other video datasets. Our results show that ML-based classification of mannerisms is a promising tool for enhancing objective diagnostic methods of behavioral observations. En ligne : https://doi.org/10.1002/aur.70020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Semi-Automated Multi-Label Classification of Autistic Mannerisms by Machine Learning on Post Hoc Skeletal Tracking [Texte imprimé et/ou numérique] / Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Naisan RAJI, Auteur ; Janina KITZEROW-CLEVEN, Auteur ; Ziyon KIM, Auteur ; Simeon PLATTE, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur . - p.833-844. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.833-844 Mots-clés : autism spectrum disorder  machine learning  mannerisms  multi-label classification  stereotypic behavior Index. décimale : PER Périodiques Résumé : ABSTRACT Mannerisms describe repetitive or unconventional body movements like arm flapping. These movements are early markers of restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD). However, assessing mannerisms reliably is challenging. Even after extensive training in behavioral observations, inter-rater agreements for mannerism items remain insufficient. The current study used machine learning (ML) to classify mannerisms from videotaped behavioral observations in children with ASD. We developed a classification scheme for mannerisms as ground truth and applied it to videotaped behavioral observations from an early intervention study. ML was used in two steps: First, the OpenPose algorithm post hoc extracted features based on body movements in the videos. Second, a long short-term memory (LSTM) neural network classified the features in a multi-label approach to distinguish between the absence of mannerisms, flapping, jumping, and both flapping + jumping. The trained models achieved 70.2% accuracy (F1 score: 31.8%) using nested cross-validation. The analysis improves on previous videotaped ML classification studies by splitting training and test data subject-wise, highlighting its clinical applicability. The LSTM models are made publicly available for use with other video datasets. Our results show that ML-based classification of mannerisms is a promising tool for enhancing objective diagnostic methods of behavioral observations. En ligne : https://doi.org/10.1002/aur.70020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Paths to Common Ground in ASD / Nirit Bauminger ZVIELY ; Yael ESTRUGO ; Maya SABAG ; Ronny GEVA in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.845-856 Titre : Paths to Common Ground in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Nirit Bauminger ZVIELY, Auteur ; Yael ESTRUGO, Auteur ; Maya SABAG, Auteur ; Ronny GEVA, Auteur Article en page(s) : p.845-856 Langues : Anglais (eng) Mots-clés : autism  common ground  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT Common ground (CG), the shared contextual knowledge serving everyday situations like conversations, is crucial for effective communication. This study delved into CG generation between peers with autism spectrum disorder (ASD, N?=?84) compared to Controls (N?=?56) children and adolescents (ages 6?16?years) paired into peer dyads. We aimed to deepen the understanding of the mechanism involved in CG efficacy among peers by exploring the roles of Theory of Mind (ToM) and Vocabulary in CG formation during play. Participants engaged in a structured task probing CG production in an ambiguous setting. Findings show that ASD and Control dyads generate CG spontaneously, yet the Control group demonstrated greater efficiency by achieving common conceptualization faster and with fewer words. Age and CG measures were correlated, outlining CG development, and Path analysis models suggested independent contributions from Vocabulary and ToM to CG efficiency. Limitations include the task's structured nature, precluding a comprehensive assessment of language and visual perception abilities. Taken together, the findings highlight the potential for interventions targeting CG acquisition in ASD, which is crucial for daily life participation. Interventions could harness cognitive processes like vocabulary and ToM to enhance dialogue efficacy among children with ASD. En ligne : https://doi.org/10.1002/aur.70006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Paths to Common Ground in ASD [Texte imprimé et/ou numérique] / Nirit Bauminger ZVIELY, Auteur ; Yael ESTRUGO, Auteur ; Maya SABAG, Auteur ; Ronny GEVA, Auteur . - p.845-856. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.845-856 Mots-clés : autism  common ground  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT Common ground (CG), the shared contextual knowledge serving everyday situations like conversations, is crucial for effective communication. This study delved into CG generation between peers with autism spectrum disorder (ASD, N?=?84) compared to Controls (N?=?56) children and adolescents (ages 6?16?years) paired into peer dyads. We aimed to deepen the understanding of the mechanism involved in CG efficacy among peers by exploring the roles of Theory of Mind (ToM) and Vocabulary in CG formation during play. Participants engaged in a structured task probing CG production in an ambiguous setting. Findings show that ASD and Control dyads generate CG spontaneously, yet the Control group demonstrated greater efficiency by achieving common conceptualization faster and with fewer words. Age and CG measures were correlated, outlining CG development, and Path analysis models suggested independent contributions from Vocabulary and ToM to CG efficiency. Limitations include the task's structured nature, precluding a comprehensive assessment of language and visual perception abilities. Taken together, the findings highlight the potential for interventions targeting CG acquisition in ASD, which is crucial for daily life participation. Interventions could harness cognitive processes like vocabulary and ToM to enhance dialogue efficacy among children with ASD. En ligne : https://doi.org/10.1002/aur.70006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Evaluating the CELF-5 Screening Test and Vineland-3 for Identifying Language Difficulties in Autism and Attention Deficit Hyperactivity Disorder / Amanda BRIGNELL ; Mia MOSES ; Kathryn KALLADY ; Mark A. BELLGROVE ; Beth P. JOHNSON in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.857-869 Titre : Evaluating the CELF-5 Screening Test and Vineland-3 for Identifying Language Difficulties in Autism and Attention Deficit Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Amanda BRIGNELL, Auteur ; Mia MOSES, Auteur ; Kathryn KALLADY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur Article en page(s) : p.857-869 Langues : Anglais (eng) Mots-clés : ADHD  autism  expressive language  receptive language  screening accuracy  screening tool Index. décimale : PER Périodiques Résumé : ABSTRACT Language screening tools are frequently used to identify children with potential undiagnosed language difficulties. These difficulties are more prevalent in autistic children and those with attention deficit hyperactivity disorder (ADHD) compared to neurotypical peers. Despite the widespread use of tools like the Clinical Evaluation of Language Fundamentals, Fifth Edition Screening Test (CELF-5 Screener) and the Vineland Adaptive Behavior Scales, Third Edition (Vineland-3), their sensitivity and specificity for this population have not been empirically validated. This study aimed to evaluate the screening accuracy of the CELF-5 Screener and Vineland-3 in children diagnosed with autism and/or ADHD and compare their performance to the gold standard measure. The sample consisted of 132 participants (n autism?=?25; n ADHD?=?29, and n autism+ADHD?=?78; M age in years?=?9.6; % male?=?59) from the Monash Autism-ADHD Genetics and Neurodevelopment Project. The sensitivity, specificity, positive predictive value, and negative predictive value of the CELF-5 Screener and Vineland-3 receptive and expressive language subdomain scores were compared against those of the clinician-administered CELF-5 receptive and expressive language composite scores. The screening accuracy of each tool was further evaluated through Receiver Operating Characteristic analyses and calculations of Youden's J statistic. The CELF-5 Screener demonstrated poor sensitivity for receptive language difficulties (35.6%) while demonstrating high specificity (95.3%). Similarly, for expressive language difficulties, the sensitivity was low (37.9%), and the specificity was high (91.1%). The Vineland-3 showed high sensitivity (93.3%) but low specificity (48%) for expressive language difficulties and inadequate sensitivity (80.9%) and specificity (22.4%) for receptive language difficulties. Both the CELF-5 Screener and Vineland-3 may miss a significant number of children with co-occurring language difficulties related to autism and/or ADHD. Examiners must understand these tools' strengths and limitations, especially when assessing neurodivergent children whose language development might not follow a normative trajectory. En ligne : https://doi.org/10.1002/aur.70021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Evaluating the CELF-5 Screening Test and Vineland-3 for Identifying Language Difficulties in Autism and Attention Deficit Hyperactivity Disorder [Texte imprimé et/ou numérique] / Amanda BRIGNELL, Auteur ; Mia MOSES, Auteur ; Kathryn KALLADY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur . - p.857-869. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.857-869 Mots-clés : ADHD  autism  expressive language  receptive language  screening accuracy  screening tool Index. décimale : PER Périodiques Résumé : ABSTRACT Language screening tools are frequently used to identify children with potential undiagnosed language difficulties. These difficulties are more prevalent in autistic children and those with attention deficit hyperactivity disorder (ADHD) compared to neurotypical peers. Despite the widespread use of tools like the Clinical Evaluation of Language Fundamentals, Fifth Edition Screening Test (CELF-5 Screener) and the Vineland Adaptive Behavior Scales, Third Edition (Vineland-3), their sensitivity and specificity for this population have not been empirically validated. This study aimed to evaluate the screening accuracy of the CELF-5 Screener and Vineland-3 in children diagnosed with autism and/or ADHD and compare their performance to the gold standard measure. The sample consisted of 132 participants (n autism?=?25; n ADHD?=?29, and n autism+ADHD?=?78; M age in years?=?9.6; % male?=?59) from the Monash Autism-ADHD Genetics and Neurodevelopment Project. The sensitivity, specificity, positive predictive value, and negative predictive value of the CELF-5 Screener and Vineland-3 receptive and expressive language subdomain scores were compared against those of the clinician-administered CELF-5 receptive and expressive language composite scores. The screening accuracy of each tool was further evaluated through Receiver Operating Characteristic analyses and calculations of Youden's J statistic. The CELF-5 Screener demonstrated poor sensitivity for receptive language difficulties (35.6%) while demonstrating high specificity (95.3%). Similarly, for expressive language difficulties, the sensitivity was low (37.9%), and the specificity was high (91.1%). The Vineland-3 showed high sensitivity (93.3%) but low specificity (48%) for expressive language difficulties and inadequate sensitivity (80.9%) and specificity (22.4%) for receptive language difficulties. Both the CELF-5 Screener and Vineland-3 may miss a significant number of children with co-occurring language difficulties related to autism and/or ADHD. Examiners must understand these tools' strengths and limitations, especially when assessing neurodivergent children whose language development might not follow a normative trajectory. En ligne : https://doi.org/10.1002/aur.70021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Age-Related Trajectories of Autistic Traits in Children With Angelman Syndrome / Sabine E. MOUS ; Leontine W. TEN HOOPEN ; André B. RIETMAN ; Kamil R. HIRALAL ; Karen G. C. B. BINDELS-DE HEUS ; Pieter F. A. DE NIJS ; Theresa C. MOHR ; Eline J. LENS ; Manon H. J. HILLEGERS ; Henriette A. MOLL ; Marie-Claire Y. DE WIT ; Gwen C. DIELEMAN in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.870-880 Titre : Age-Related Trajectories of Autistic Traits in Children With Angelman Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Sabine E. MOUS, Auteur ; Leontine W. TEN HOOPEN, Auteur ; André B. RIETMAN, Auteur ; Kamil R. HIRALAL, Auteur ; Karen G. C. B. BINDELS-DE HEUS, Auteur ; Pieter F. A. DE NIJS, Auteur ; Theresa C. MOHR, Auteur ; Eline J. LENS, Auteur ; Manon H. J. HILLEGERS, Auteur ; Henriette A. MOLL, Auteur ; Marie-Claire Y. DE WIT, Auteur ; Gwen C. DIELEMAN, Auteur Article en page(s) : p.870-880 Langues : Anglais (eng) Mots-clés : Angelman syndrome  Autism Spectrum Disorder  autistic traits  longitudinal  repeated measures  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Angelman syndrome (AS) is a rare neurogenetic disorder. Previous studies indicate a high prevalence of autism spectrum disorder (ASD) with considerable variability. Little is known regarding the longitudinal trajectory of autistic traits. We aim to investigate autistic traits, the effect of age on these traits, and associated features in AS children. This (partly) longitudinal clinical record study at the ENCORE Expertise Center involved 107 AS children aged 2?18 with one (N?=?107), two (N?=?49), or three (N?=?14) measurements. Autistic traits and sensory processing issues were assessed using various instruments, and DSM classifications were used descriptively. Covariates were genotype, gender, and epilepsy. Results indicate a high prevalence of autistic traits and sensory processing issues. Children with the deletion genotype exhibited more autistic traits. Autism Diagnostic Observation Schedule (ADOS) classifications indicated higher rates of ASD compared to clinician DSM classifications. Autistic traits generally remained stable over time, except that ADOS scores significantly decreased for children with the UBE3A mutation genotype, and in the social affect domain for the entire group. In conclusion, incorporating the assessment of autistic traits and sensory processing into clinical practice for AS is important to inform adaptations of the environment to meet the child?s needs. Additionally, clinicians and researchers should be mindful of the potential for overestimating ASD traits in AS when relying on the ADOS. ASD diagnosis in AS should integrate multiple diagnostic instruments, diverse hetero-anamnestic sources, and multidisciplinary expert opinions. En ligne : https://doi.org/10.1002/aur.70017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Age-Related Trajectories of Autistic Traits in Children With Angelman Syndrome [Texte imprimé et/ou numérique] / Sabine E. MOUS, Auteur ; Leontine W. TEN HOOPEN, Auteur ; André B. RIETMAN, Auteur ; Kamil R. HIRALAL, Auteur ; Karen G. C. B. BINDELS-DE HEUS, Auteur ; Pieter F. A. DE NIJS, Auteur ; Theresa C. MOHR, Auteur ; Eline J. LENS, Auteur ; Manon H. J. HILLEGERS, Auteur ; Henriette A. MOLL, Auteur ; Marie-Claire Y. DE WIT, Auteur ; Gwen C. DIELEMAN, Auteur . - p.870-880. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.870-880 Mots-clés : Angelman syndrome  Autism Spectrum Disorder  autistic traits  longitudinal  repeated measures  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Angelman syndrome (AS) is a rare neurogenetic disorder. Previous studies indicate a high prevalence of autism spectrum disorder (ASD) with considerable variability. Little is known regarding the longitudinal trajectory of autistic traits. We aim to investigate autistic traits, the effect of age on these traits, and associated features in AS children. This (partly) longitudinal clinical record study at the ENCORE Expertise Center involved 107 AS children aged 2?18 with one (N?=?107), two (N?=?49), or three (N?=?14) measurements. Autistic traits and sensory processing issues were assessed using various instruments, and DSM classifications were used descriptively. Covariates were genotype, gender, and epilepsy. Results indicate a high prevalence of autistic traits and sensory processing issues. Children with the deletion genotype exhibited more autistic traits. Autism Diagnostic Observation Schedule (ADOS) classifications indicated higher rates of ASD compared to clinician DSM classifications. Autistic traits generally remained stable over time, except that ADOS scores significantly decreased for children with the UBE3A mutation genotype, and in the social affect domain for the entire group. In conclusion, incorporating the assessment of autistic traits and sensory processing into clinical practice for AS is important to inform adaptations of the environment to meet the child?s needs. Additionally, clinicians and researchers should be mindful of the potential for overestimating ASD traits in AS when relying on the ADOS. ASD diagnosis in AS should integrate multiple diagnostic instruments, diverse hetero-anamnestic sources, and multidisciplinary expert opinions. En ligne : https://doi.org/10.1002/aur.70017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Household Income, Maternal Allostatic Load During Pregnancy, and Offspring With Autism Spectrum Disorders / Shoji F. NAKAYAMA ; Takeo FUJIWARA ; Environment THE JAPAN ; Group CHILDREN'S STUDY in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.881-890 Titre : Household Income, Maternal Allostatic Load During Pregnancy, and Offspring With Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Shoji F. NAKAYAMA, Auteur ; Takeo FUJIWARA, Auteur ; Environment THE JAPAN, Auteur ; Group CHILDREN'S STUDY, Auteur Article en page(s) : p.881-890 Langues : Anglais (eng) Mots-clés : allostasis  autistic disorder  income  poverty Index. décimale : PER Périodiques Résumé : ABSTRACT Relative maternal poverty is a suggested social determinant of autism spectrum disorders (ASDs) in offspring; however, this association may be confounded by the maternal broader autism phenotype (BAP). The biological mechanisms underlying this association are largely understudied. We examined the association between household income during pregnancy and ASDs in offspring, adjusting for confounders including maternal BAP, and explored whether maternal chronic stress, measured by allostatic load (AL) during pregnancy, mediates this association. Data on 59,998 mother?child dyads were obtained from the Japan Environment and Children's Study, a nationwide birth cohort. Household income was categorized into tertiles (?6 million JPY) and offspring ASD diagnosis by age four was assessed via guardian's report. Bayesian logistic regression models indicated that mothers from low- and middle-income households had a 58% (95% credible interval [CI]: 28%?98%) and a 37% (95% CI: 12%?70%) higher risk of offspring ASDs, respectively, compared to those from high-income households. AL, defined as three or more out of 10 biomarkers in the highest risk quartile, did not mediate these associations. Low and middle household income during pregnancy was associated with a higher risk of ASD diagnosis, and high AL did not mediate this association. En ligne : https://doi.org/10.1002/aur.70022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Household Income, Maternal Allostatic Load During Pregnancy, and Offspring With Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Shoji F. NAKAYAMA, Auteur ; Takeo FUJIWARA, Auteur ; Environment THE JAPAN, Auteur ; Group CHILDREN'S STUDY, Auteur . - p.881-890. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.881-890 Mots-clés : allostasis  autistic disorder  income  poverty Index. décimale : PER Périodiques Résumé : ABSTRACT Relative maternal poverty is a suggested social determinant of autism spectrum disorders (ASDs) in offspring; however, this association may be confounded by the maternal broader autism phenotype (BAP). The biological mechanisms underlying this association are largely understudied. We examined the association between household income during pregnancy and ASDs in offspring, adjusting for confounders including maternal BAP, and explored whether maternal chronic stress, measured by allostatic load (AL) during pregnancy, mediates this association. Data on 59,998 mother?child dyads were obtained from the Japan Environment and Children's Study, a nationwide birth cohort. Household income was categorized into tertiles (?6 million JPY) and offspring ASD diagnosis by age four was assessed via guardian's report. Bayesian logistic regression models indicated that mothers from low- and middle-income households had a 58% (95% credible interval [CI]: 28%?98%) and a 37% (95% CI: 12%?70%) higher risk of offspring ASDs, respectively, compared to those from high-income households. AL, defined as three or more out of 10 biomarkers in the highest risk quartile, did not mediate these associations. Low and middle household income during pregnancy was associated with a higher risk of ASD diagnosis, and high AL did not mediate this association. En ligne : https://doi.org/10.1002/aur.70022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554