Dépouillements

Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis / Xingxing LIAO ; Kaiyue HAN ; Maoyuan NIU ; Jiarou CHEN ; Xianna Wang ; Jianjun LIU ; Yan ZHANG ; Hao Zhang in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1497-1512 Titre : Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Xingxing LIAO, Auteur ; Kaiyue HAN, Auteur ; Maoyuan NIU, Auteur ; Jiarou CHEN, Auteur ; Xianna Wang, Auteur ; Jianjun LIU, Auteur ; Yan ZHANG, Auteur ; Hao Zhang, Auteur Article en page(s) : p.1497-1512 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  insulin-like growth factor-1  meta-analysis  systematic review  thyroid hormone Index. décimale : PER Périodiques Résumé : ABSTRACT The action of the thyroid hormones and insulin-like growth factor 1 (IGF-1) is interdependent. The levels of thyroid hormone and IGF-1 were reported to be altered in individuals with autism spectrum disorder (ASD), but the results were controversial. This study aims to compare levels of thyroxine, triiodothyronine, thyroid stimulating hormone, and IGF-1 between the ASD group and neurotypical controls. PubMed, Web of Science, Cochrane, and Embase databases were searched for eligible observational studies. We calculated pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) of our data using a random or fixed effect model. The search strategy provided a total of 1710 articles, of which 16 articles were quantitatively analyzed. The total number of included participants was 2399 (1285 cases and 1114 controls). The meta-analysis revealed no significantly changed blood levels of thyroxine, free triiodothyronine, free thyroxine, and IGF-1 of subjects with ASD compared to non-autistic controls. The blood TSH levels were significantly lower in ASD subjects than in controls (n?=?859, Hedges' g?=??1.18, 95% CI: ?2.17 to ?0.20, p?=?0.02). Subgroup-analysis results showed that blood free triiodothyronine (n?=?153, Hedges' g?=??0.74, 95% CI: ?1.08 to ?0.40, p? En ligne : https://doi.org/10.1002/aur.70052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Xingxing LIAO, Auteur ; Kaiyue HAN, Auteur ; Maoyuan NIU, Auteur ; Jiarou CHEN, Auteur ; Xianna Wang, Auteur ; Jianjun LIU, Auteur ; Yan ZHANG, Auteur ; Hao Zhang, Auteur . - p.1497-1512. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1497-1512 Mots-clés : autism spectrum disorder  insulin-like growth factor-1  meta-analysis  systematic review  thyroid hormone Index. décimale : PER Périodiques Résumé : ABSTRACT The action of the thyroid hormones and insulin-like growth factor 1 (IGF-1) is interdependent. The levels of thyroid hormone and IGF-1 were reported to be altered in individuals with autism spectrum disorder (ASD), but the results were controversial. This study aims to compare levels of thyroxine, triiodothyronine, thyroid stimulating hormone, and IGF-1 between the ASD group and neurotypical controls. PubMed, Web of Science, Cochrane, and Embase databases were searched for eligible observational studies. We calculated pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) of our data using a random or fixed effect model. The search strategy provided a total of 1710 articles, of which 16 articles were quantitatively analyzed. The total number of included participants was 2399 (1285 cases and 1114 controls). The meta-analysis revealed no significantly changed blood levels of thyroxine, free triiodothyronine, free thyroxine, and IGF-1 of subjects with ASD compared to non-autistic controls. The blood TSH levels were significantly lower in ASD subjects than in controls (n?=?859, Hedges' g?=??1.18, 95% CI: ?2.17 to ?0.20, p?=?0.02). Subgroup-analysis results showed that blood free triiodothyronine (n?=?153, Hedges' g?=??0.74, 95% CI: ?1.08 to ?0.40, p? En ligne : https://doi.org/10.1002/aur.70052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Developing Inner Speech to Help Autistic Individuals Improve Their Self-Regulation Ability: A Pilot Randomized-Controlled Trial / Janice NATHAN ; Barry R. NATHAN ; Miriam SHEYNBLYUM ; Valire Carr COPELAND ; Carla A. MAZEFSKY ; Shaun M. EACK in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1489-1496 Titre : Developing Inner Speech to Help Autistic Individuals Improve Their Self-Regulation Ability: A Pilot Randomized-Controlled Trial Type de document : Texte imprimé et/ou numérique Auteurs : Janice NATHAN, Auteur ; Barry R. NATHAN, Auteur ; Miriam SHEYNBLYUM, Auteur ; Valire Carr COPELAND, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur Article en page(s) : p.1489-1496 Langues : Anglais (eng) Mots-clés : autistic children  emotional dysregulation  inner speech  neurocognitive  self-regulation  therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Some autistic children often have difficulty regulating their emotions. This pilot study evaluated the effectiveness of an intervention to reduce emotional dysregulation by developing inner speech in autistic children. The therapy is called Thinking in Speech (TiS). Nine certified speech-language pathologists were trained remotely. They, in turn, remotely administered TiS to 22 autistic children. Participating children were randomly assigned to either a therapy immediate or a waitlist control condition. Both groups received sixteen 30-min therapy sessions over 8?10?weeks. Parents rated the amount of emotional dysregulation on three measures before the intervention and after the sixteen 30-min therapy sessions. Results showed significant results on the Emotion Dysregulation Inventory-Dysphoria Scale (F?=?5.49, n?=?11, p?=?0.008), and marginally significant results on the Emotion Dysregulation Inventory Index Regulation Index-Reactivity Scale (F?=?2.57, n?=?11, p?=?0.089). Such findings suggest a potential impact of developing inner speech to reduce emotion dysregulation in autistic children. En ligne : https://doi.org/10.1002/aur.70053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Developing Inner Speech to Help Autistic Individuals Improve Their Self-Regulation Ability: A Pilot Randomized-Controlled Trial [Texte imprimé et/ou numérique] / Janice NATHAN, Auteur ; Barry R. NATHAN, Auteur ; Miriam SHEYNBLYUM, Auteur ; Valire Carr COPELAND, Auteur ; Carla A. MAZEFSKY, Auteur ; Shaun M. EACK, Auteur . - p.1489-1496. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1489-1496 Mots-clés : autistic children  emotional dysregulation  inner speech  neurocognitive  self-regulation  therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Some autistic children often have difficulty regulating their emotions. This pilot study evaluated the effectiveness of an intervention to reduce emotional dysregulation by developing inner speech in autistic children. The therapy is called Thinking in Speech (TiS). Nine certified speech-language pathologists were trained remotely. They, in turn, remotely administered TiS to 22 autistic children. Participating children were randomly assigned to either a therapy immediate or a waitlist control condition. Both groups received sixteen 30-min therapy sessions over 8?10?weeks. Parents rated the amount of emotional dysregulation on three measures before the intervention and after the sixteen 30-min therapy sessions. Results showed significant results on the Emotion Dysregulation Inventory-Dysphoria Scale (F?=?5.49, n?=?11, p?=?0.008), and marginally significant results on the Emotion Dysregulation Inventory Index Regulation Index-Reactivity Scale (F?=?2.57, n?=?11, p?=?0.089). Such findings suggest a potential impact of developing inner speech to reduce emotion dysregulation in autistic children. En ligne : https://doi.org/10.1002/aur.70053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Identifying Daily Living Skills From Childhood and Adolescence Predictive of Adult Outcomes in a Longitudinal Study of Autism and Related Developmental Conditions / Catherine LORD in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1474-1488 Titre : Identifying Daily Living Skills From Childhood and Adolescence Predictive of Adult Outcomes in a Longitudinal Study of Autism and Related Developmental Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Catherine LORD, Auteur Article en page(s) : p.1474-1488 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Challenges in daily living skills (DLS) are well-documented in autism and other developmental conditions. Research has also cataloged challenges in adult outcome attainment among autistic individuals and those with other developmental conditions; stronger DLS are associated with a higher likelihood of attaining some adult outcomes. Little work has examined whether competency in specific DLS increases the likelihood of attaining adult outcomes. The current study examined mean item set scores from the DLS domain of the first and second editions of the Vineland Adaptive Behavior Scales (VABS) in a sample (n?=?230) drawn from a well-characterized longitudinal cohort. Differences in growth patterns in DLS item set scores based on cognitive ability were examined from ages 5?18. The utility of DLS item set scores from ages 5, 9, 14, and 18 for predicting adult employment, relationship, living, and well-being outcomes at approximately age 33 was then tested. For all participants, DLS item sets from the community subdomain (i.e., eating out skills, pre-job skills) were low throughout childhood and showed the least growth over time. For participants with IQ??70, community subdomain item sets had the most predictive utility. Competency in personal DLS may promote positive outcomes for autistic individuals with IQ? En ligne : https://doi.org/10.1002/aur.70056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Identifying Daily Living Skills From Childhood and Adolescence Predictive of Adult Outcomes in a Longitudinal Study of Autism and Related Developmental Conditions [Texte imprimé et/ou numérique] / Catherine LORD, Auteur . - p.1474-1488. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1474-1488 Index. décimale : PER Périodiques Résumé : ABSTRACT Challenges in daily living skills (DLS) are well-documented in autism and other developmental conditions. Research has also cataloged challenges in adult outcome attainment among autistic individuals and those with other developmental conditions; stronger DLS are associated with a higher likelihood of attaining some adult outcomes. Little work has examined whether competency in specific DLS increases the likelihood of attaining adult outcomes. The current study examined mean item set scores from the DLS domain of the first and second editions of the Vineland Adaptive Behavior Scales (VABS) in a sample (n?=?230) drawn from a well-characterized longitudinal cohort. Differences in growth patterns in DLS item set scores based on cognitive ability were examined from ages 5?18. The utility of DLS item set scores from ages 5, 9, 14, and 18 for predicting adult employment, relationship, living, and well-being outcomes at approximately age 33 was then tested. For all participants, DLS item sets from the community subdomain (i.e., eating out skills, pre-job skills) were low throughout childhood and showed the least growth over time. For participants with IQ??70, community subdomain item sets had the most predictive utility. Competency in personal DLS may promote positive outcomes for autistic individuals with IQ? En ligne : https://doi.org/10.1002/aur.70056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Maternal Touch During Mother-Infant Interactions in Infants With and Without an Elevated Likelihood for Autism: Links With Symptom-Level Difficulties of Maternal Psychological Stress / P. WARREYN ; F. MOERMAN ; T. VAN LIERDE ; A. ZANATTA ; H. ROEYERS in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1461-1473 Titre : Maternal Touch During Mother-Infant Interactions in Infants With and Without an Elevated Likelihood for Autism: Links With Symptom-Level Difficulties of Maternal Psychological Stress Type de document : Texte imprimé et/ou numérique Auteurs : P. WARREYN, Auteur ; F. MOERMAN, Auteur ; T. VAN LIERDE, Auteur ; A. ZANATTA, Auteur ; H. ROEYERS, Auteur Article en page(s) : p.1461-1473 Langues : Anglais (eng) Mots-clés : autism  elevated likelihood  premature  psychological stress  siblings  touch Index. décimale : PER Périodiques Résumé : ABSTRACT Infants at elevated likelihood for autism (EL infants) have varied developmental outcomes. This exposes parents to a unique parenting journey, and in some, heightened psychological stress. This study investigated how maternal psychological stress is linked to variations in mother?infant interactions, specifically touch. We focused on mothers of EL infants, including infants with an older autistic sibling and infants born preterm ( En ligne : https://doi.org/10.1002/aur.70067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Maternal Touch During Mother-Infant Interactions in Infants With and Without an Elevated Likelihood for Autism: Links With Symptom-Level Difficulties of Maternal Psychological Stress [Texte imprimé et/ou numérique] / P. WARREYN, Auteur ; F. MOERMAN, Auteur ; T. VAN LIERDE, Auteur ; A. ZANATTA, Auteur ; H. ROEYERS, Auteur . - p.1461-1473. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1461-1473 Mots-clés : autism  elevated likelihood  premature  psychological stress  siblings  touch Index. décimale : PER Périodiques Résumé : ABSTRACT Infants at elevated likelihood for autism (EL infants) have varied developmental outcomes. This exposes parents to a unique parenting journey, and in some, heightened psychological stress. This study investigated how maternal psychological stress is linked to variations in mother?infant interactions, specifically touch. We focused on mothers of EL infants, including infants with an older autistic sibling and infants born preterm ( En ligne : https://doi.org/10.1002/aur.70067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Prospective Memory Performance of Autistic Adults in Everyday Life: The Role of Stress and Motivation / Mareike ALTGASSEN in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1447-1460 Titre : Prospective Memory Performance of Autistic Adults in Everyday Life: The Role of Stress and Motivation Type de document : Texte imprimé et/ou numérique Auteurs : Mareike ALTGASSEN, Auteur Article en page(s) : p.1447-1460 Langues : Anglais (eng) Mots-clés : autism  everyday life  experience sampling method  high-functioning autism  motivation  prospective memory  stress Index. décimale : PER Périodiques Résumé : ABSTRACT Prospective memory (PM) is the ability to remember to carry out intended actions in the future. The present study investigated the PM performance of autistic adults in everyday life. A total of 29 autistic participants and 30 controls matched for age, gender, and cognitive abilities completed various PM tasks (time-based vs. event-based; externally-assigned vs. self-assigned), integrated into a three-day Experience Sampling Method (ESM) assessment. The ESM survey assessed other activities performed during the 3?days, participants' motivation, daily routine, and perceived daily-life stress. No group differences were found between autistic and control participants in any of the various PM tasks. Autistic participants did not differ from control participants in the types of everyday activities performed or in motivation, but showed higher levels of perceived stress. This is the first study to investigate PM performance of autistic individuals in everyday life. The results suggest that autistic adults show no PM difficulties in naturalistic PM tasks. En ligne : https://doi.org/10.1002/aur.70057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Prospective Memory Performance of Autistic Adults in Everyday Life: The Role of Stress and Motivation [Texte imprimé et/ou numérique] / Mareike ALTGASSEN, Auteur . - p.1447-1460. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1447-1460 Mots-clés : autism  everyday life  experience sampling method  high-functioning autism  motivation  prospective memory  stress Index. décimale : PER Périodiques Résumé : ABSTRACT Prospective memory (PM) is the ability to remember to carry out intended actions in the future. The present study investigated the PM performance of autistic adults in everyday life. A total of 29 autistic participants and 30 controls matched for age, gender, and cognitive abilities completed various PM tasks (time-based vs. event-based; externally-assigned vs. self-assigned), integrated into a three-day Experience Sampling Method (ESM) assessment. The ESM survey assessed other activities performed during the 3?days, participants' motivation, daily routine, and perceived daily-life stress. No group differences were found between autistic and control participants in any of the various PM tasks. Autistic participants did not differ from control participants in the types of everyday activities performed or in motivation, but showed higher levels of perceived stress. This is the first study to investigate PM performance of autistic individuals in everyday life. The results suggest that autistic adults show no PM difficulties in naturalistic PM tasks. En ligne : https://doi.org/10.1002/aur.70057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Feedback-Driven Learning Through Eye Movements in Autism Spectrum Disorder / David SALDANA ; Mila VULCHANOVA ; Maria Luisa SCATTONI ; Martina MICAI in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1431-1446 Titre : Feedback-Driven Learning Through Eye Movements in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : David SALDANA, Auteur ; Mila VULCHANOVA, Auteur ; Maria Luisa SCATTONI, Auteur ; Martina MICAI, Auteur Article en page(s) : p.1431-1446 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  executive function  eye movements  feedback  neuropsychological tests Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with Autism Spectrum Disorder (ASD) face challenges in cognitive flexibility and rule-shifting. This study investigated a computerized Wisconsin Card Sorting Task (WCST) paired with eye-tracking to understand the cognitive dynamics of set-shifting difficulties in autistic children and adolescents. The study included 21 Spanish-speaking autistic children and adolescents (mean age: 14.5?years) and 22 typically developing peers (mean age: 15.1), matched by gender, age, language, working memory, and intelligence. Participants sorted cards by number, color, or shape, receiving feedback after each trial. The sorting criterion changed after 10 correct responses without participants' prior knowledge. The task included 128 trials, followed by three strategy-related verbal questions. Behavioral and eye movement data showed that the autistic group performed worse, completing fewer sets and making more errors. Both groups had increased fixations and dwell time after feedback, but controls had a greater increase after incorrect responses. Autistic individuals may struggle with error monitoring and response inhibition, impacting their adaptability and less efficient learning of sorting rules. They engaged less in error analysis and correction than controls. Targeted interventions to enhance feedback processing and adaptive learning strategies could benefit autistic individuals. Future research should explore mechanisms behind eye-movement differences and the effectiveness of related interventions. En ligne : https://doi.org/10.1002/aur.70060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Feedback-Driven Learning Through Eye Movements in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / David SALDANA, Auteur ; Mila VULCHANOVA, Auteur ; Maria Luisa SCATTONI, Auteur ; Martina MICAI, Auteur . - p.1431-1446. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1431-1446 Mots-clés : autism spectrum disorder  executive function  eye movements  feedback  neuropsychological tests Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with Autism Spectrum Disorder (ASD) face challenges in cognitive flexibility and rule-shifting. This study investigated a computerized Wisconsin Card Sorting Task (WCST) paired with eye-tracking to understand the cognitive dynamics of set-shifting difficulties in autistic children and adolescents. The study included 21 Spanish-speaking autistic children and adolescents (mean age: 14.5?years) and 22 typically developing peers (mean age: 15.1), matched by gender, age, language, working memory, and intelligence. Participants sorted cards by number, color, or shape, receiving feedback after each trial. The sorting criterion changed after 10 correct responses without participants' prior knowledge. The task included 128 trials, followed by three strategy-related verbal questions. Behavioral and eye movement data showed that the autistic group performed worse, completing fewer sets and making more errors. Both groups had increased fixations and dwell time after feedback, but controls had a greater increase after incorrect responses. Autistic individuals may struggle with error monitoring and response inhibition, impacting their adaptability and less efficient learning of sorting rules. They engaged less in error analysis and correction than controls. Targeted interventions to enhance feedback processing and adaptive learning strategies could benefit autistic individuals. Future research should explore mechanisms behind eye-movement differences and the effectiveness of related interventions. En ligne : https://doi.org/10.1002/aur.70060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Assessing the Validity and Reliability of the Chinese Vineland Adaptive Behavior Scales for Children With Autism Spectrum Disorder Aged 1-6 / Mingyu XU ; Yubin HU ; Yuqi LIU ; Zilin CHEN ; Hangyu TAN ; Wenchong DU ; Yaqiong XIAO ; Fei Li in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1412-1430 Titre : Assessing the Validity and Reliability of the Chinese Vineland Adaptive Behavior Scales for Children With Autism Spectrum Disorder Aged 1-6 Type de document : Texte imprimé et/ou numérique Auteurs : Mingyu XU, Auteur ; Yubin HU, Auteur ; Yuqi LIU, Auteur ; Zilin CHEN, Auteur ; Hangyu TAN, Auteur ; Wenchong DU, Auteur ; Yaqiong XIAO, Auteur ; Fei Li, Auteur Article en page(s) : p.1412-1430 Langues : Anglais (eng) Mots-clés : adaptive behaviors  cross cultural comparison  developmental neuropsychological assessment  reliability and validity  translating Index. décimale : PER Périodiques Résumé : ABSTRACT The Vineland Adaptive Behavior Scales (VABS), a widely used assessment tool for assessing developmental profiles of children, has been adapted to various cultural contexts with proven efficacy. This study evaluated the applicability and efficacy of the Chinese Vineland Adaptive Behavior Scales (CVABS-III) in assessing children with different developmental profiles within the context of Chinese culture. The VABS items were meticulously translated and modified to reflect cultural relevancy. We assessed 2118 Chinese preschoolers aged 1?6?years, including those with typical development (TD; n?=?943), and various clinical subgroups including autism spectrum disorder (ASD; n?=?449), developmental delay (DD; n?=?477), and speech and language developmental delay (SLDD; n?=?249). Internal reliability, construct validity, and discriminant validity with the Gesell Developmental Schedules were assessed. The CVABS-III demonstrated excellent internal consistency and construct validity. It effectively distinguished between TD children and those with ASD, DD, or SLDD. It also showed progressively stronger correlations with the Gesell Developmental Schedules especially in children aged 3?6?years. These findings confirm that the CVABS-III retains the robust psychometric properties of its original VABS while being suitably adapted for the Chinese context. This adaptation enhances the scale's utility for early identification and intervention in developmental delays within diverse Chinese populations. Future research might explore further refinement to improve its applicability across all ages and developmental conditions. En ligne : https://doi.org/10.1002/aur.70045 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Assessing the Validity and Reliability of the Chinese Vineland Adaptive Behavior Scales for Children With Autism Spectrum Disorder Aged 1-6 [Texte imprimé et/ou numérique] / Mingyu XU, Auteur ; Yubin HU, Auteur ; Yuqi LIU, Auteur ; Zilin CHEN, Auteur ; Hangyu TAN, Auteur ; Wenchong DU, Auteur ; Yaqiong XIAO, Auteur ; Fei Li, Auteur . - p.1412-1430. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1412-1430 Mots-clés : adaptive behaviors  cross cultural comparison  developmental neuropsychological assessment  reliability and validity  translating Index. décimale : PER Périodiques Résumé : ABSTRACT The Vineland Adaptive Behavior Scales (VABS), a widely used assessment tool for assessing developmental profiles of children, has been adapted to various cultural contexts with proven efficacy. This study evaluated the applicability and efficacy of the Chinese Vineland Adaptive Behavior Scales (CVABS-III) in assessing children with different developmental profiles within the context of Chinese culture. The VABS items were meticulously translated and modified to reflect cultural relevancy. We assessed 2118 Chinese preschoolers aged 1?6?years, including those with typical development (TD; n?=?943), and various clinical subgroups including autism spectrum disorder (ASD; n?=?449), developmental delay (DD; n?=?477), and speech and language developmental delay (SLDD; n?=?249). Internal reliability, construct validity, and discriminant validity with the Gesell Developmental Schedules were assessed. The CVABS-III demonstrated excellent internal consistency and construct validity. It effectively distinguished between TD children and those with ASD, DD, or SLDD. It also showed progressively stronger correlations with the Gesell Developmental Schedules especially in children aged 3?6?years. These findings confirm that the CVABS-III retains the robust psychometric properties of its original VABS while being suitably adapted for the Chinese context. This adaptation enhances the scale's utility for early identification and intervention in developmental delays within diverse Chinese populations. Future research might explore further refinement to improve its applicability across all ages and developmental conditions. En ligne : https://doi.org/10.1002/aur.70045 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Mechanisms of Altered Imitation in Autism Spectrum Disorders / Ata KOLDAY ; Ericka L. WODKA ; Stewart H. MOSTOFSKY ; Brian S. CAFFO ; Joshua B. EWEN in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1397-1411 Titre : Mechanisms of Altered Imitation in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ata KOLDAY, Auteur ; Ericka L. WODKA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Brian S. CAFFO, Auteur ; Joshua B. EWEN, Auteur Article en page(s) : p.1397-1411 Langues : Anglais (eng) Mots-clés : autism  autism spectrum disorder  cognition  executive function  mediation analysis  movement Index. décimale : PER Périodiques Résumé : ABSTRACT Imitation plays a critical role in enhancing social reciprocity and social/non-social skill learning. Accordingly, impaired imitation may have downstream implications on skill acquisition in autism. Social, motor, representational, and executive processes contribute to imitation performance, but it is unknown the degree to which differences in these domains contribute to imitation differences in autism. In the present study, we evaluated the role of various psychological mechanisms of autism-related imitation differences using mediation models. We assessed autistic and non-autistic 7?12-year-old children (n?=?708) with FSIQ ??80, using a wide battery of performance-based and parent-report tests that measured meaningful and non-meaningful gesture imitation performance, motor execution, action representation, social motivation, and executive function processes. Multiple marginal mediation analyses revealed that motor execution tests most strongly mediated imitation deficits in autism, though effects from social motivation, action representation, and executive function also partially mediated the relationship between autism diagnosis and imitation performance. Using cross-validated regression models, the domains tested here accounted for 39% of the variation in imitation performance. Results are contextualized across a broad range of experimental and observational studies with respect to the prompted imitation task utilized here. Future research will require longitudinal data, particularly from earlier stages of development. En ligne : https://doi.org/10.1002/aur.70046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Mechanisms of Altered Imitation in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Ata KOLDAY, Auteur ; Ericka L. WODKA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Brian S. CAFFO, Auteur ; Joshua B. EWEN, Auteur . - p.1397-1411. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1397-1411 Mots-clés : autism  autism spectrum disorder  cognition  executive function  mediation analysis  movement Index. décimale : PER Périodiques Résumé : ABSTRACT Imitation plays a critical role in enhancing social reciprocity and social/non-social skill learning. Accordingly, impaired imitation may have downstream implications on skill acquisition in autism. Social, motor, representational, and executive processes contribute to imitation performance, but it is unknown the degree to which differences in these domains contribute to imitation differences in autism. In the present study, we evaluated the role of various psychological mechanisms of autism-related imitation differences using mediation models. We assessed autistic and non-autistic 7?12-year-old children (n?=?708) with FSIQ ??80, using a wide battery of performance-based and parent-report tests that measured meaningful and non-meaningful gesture imitation performance, motor execution, action representation, social motivation, and executive function processes. Multiple marginal mediation analyses revealed that motor execution tests most strongly mediated imitation deficits in autism, though effects from social motivation, action representation, and executive function also partially mediated the relationship between autism diagnosis and imitation performance. Using cross-validated regression models, the domains tested here accounted for 39% of the variation in imitation performance. Results are contextualized across a broad range of experimental and observational studies with respect to the prompted imitation task utilized here. Future research will require longitudinal data, particularly from earlier stages of development. En ligne : https://doi.org/10.1002/aur.70046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Factor Structure and Psychometric Properties of the Child Social Preference Scale-3 in Children With Autism / Antonio Y. HARDAN ; Emily SPACKMAN ; Emma BAKER ; Thomas W. FRAZIER ; Mirko ULJAREVIC in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1389-1396 Titre : Factor Structure and Psychometric Properties of the Child Social Preference Scale-3 in Children With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Antonio Y. HARDAN, Auteur ; Emily SPACKMAN, Auteur ; Emma BAKER, Auteur ; Thomas W. FRAZIER, Auteur ; Mirko ULJAREVIC, Auteur Article en page(s) : p.1389-1396 Langues : Anglais (eng) Mots-clés : approach  autism  avoidance  factor analysis  social withdrawal Index. décimale : PER Périodiques Résumé : ABSTRACT Considerable variability in social engagement among individuals with autism is well documented. Since multiple processes may contribute to this heterogeneity, validating tools to assess these differences is crucial. Originally developed in the general population, the Child Social Preference Scale (CSPS-3) aims to assess distinct forms of social disengagement arising from different combinations of approach and avoidance motivations and holds promise for delineating variability in social behaviors within autism spectrum disorder (ASD). This study investigated the factor structure and psychometric properties of the CSPS-3 in a sample of 689 children diagnosed with autism (Mage?=?11.23, SD?=?3.56; 76% male). The results suggest that a bifactor model, consisting of a general factor and three subscales (shyness, unsociability, and social avoidance), provided the best fit to the data, with the general factor accounting for most of the variance. While the subscales demonstrated adequate internal consistency, their construct reliability and stability varied, with much of the reliable variance attributed to the general factor. The structure was consistent across age and sex subgroups, and the subscales showed distinct patterns of associations with key clinical correlates. These findings support the CSPS-3's utility in assessing diverse forms of social disengagement in the autism population, while indicating that the subscales could be refined to better capture their unique aspects. En ligne : https://doi.org/10.1002/aur.70059 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Factor Structure and Psychometric Properties of the Child Social Preference Scale-3 in Children With Autism [Texte imprimé et/ou numérique] / Antonio Y. HARDAN, Auteur ; Emily SPACKMAN, Auteur ; Emma BAKER, Auteur ; Thomas W. FRAZIER, Auteur ; Mirko ULJAREVIC, Auteur . - p.1389-1396. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1389-1396 Mots-clés : approach  autism  avoidance  factor analysis  social withdrawal Index. décimale : PER Périodiques Résumé : ABSTRACT Considerable variability in social engagement among individuals with autism is well documented. Since multiple processes may contribute to this heterogeneity, validating tools to assess these differences is crucial. Originally developed in the general population, the Child Social Preference Scale (CSPS-3) aims to assess distinct forms of social disengagement arising from different combinations of approach and avoidance motivations and holds promise for delineating variability in social behaviors within autism spectrum disorder (ASD). This study investigated the factor structure and psychometric properties of the CSPS-3 in a sample of 689 children diagnosed with autism (Mage?=?11.23, SD?=?3.56; 76% male). The results suggest that a bifactor model, consisting of a general factor and three subscales (shyness, unsociability, and social avoidance), provided the best fit to the data, with the general factor accounting for most of the variance. While the subscales demonstrated adequate internal consistency, their construct reliability and stability varied, with much of the reliable variance attributed to the general factor. The structure was consistent across age and sex subgroups, and the subscales showed distinct patterns of associations with key clinical correlates. These findings support the CSPS-3's utility in assessing diverse forms of social disengagement in the autism population, while indicating that the subscales could be refined to better capture their unique aspects. En ligne : https://doi.org/10.1002/aur.70059 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Screening for Avoidant/Restrictive Food Intake Disorder Symptoms Among Autistic Adults: Measurement Invariance With a Comparison General Sample / Goldie A. MCQUAID ; Gregory L. WALLACE ; Hana F. ZICKGRAF in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1381-1388 Titre : Screening for Avoidant/Restrictive Food Intake Disorder Symptoms Among Autistic Adults: Measurement Invariance With a Comparison General Sample Type de document : Texte imprimé et/ou numérique Auteurs : Goldie A. MCQUAID, Auteur ; Gregory L. WALLACE, Auteur ; Hana F. ZICKGRAF, Auteur Article en page(s) : p.1381-1388 Langues : Anglais (eng) Mots-clés : adults  autism spectrum disorder  avoidant/restrictive food intake disorder  general population  measurement invariance Index. décimale : PER Périodiques Résumé : ABSTRACT Research suggests a higher prevalence of avoidant/restrictive food intake disorder (ARFID) in autistic people across the lifespan compared to the general population. However, ARFID symptoms in autistic people may be misattributed to core autistic traits and gastrointestinal symptoms that often co-occur with autism. This diagnostic overshadowing could lead to the under-recognition and under-treatment of modifiable symptoms of psychopathology in autistic people. Validating ARFID symptom measures in this population is essential to screening for ARFID and tracking treatment outcomes in this population. Multigroup confirmatory factor analysis was used to evaluate the equivalence of the factor structure, factor loadings, and item intercepts of the Nine-Item ARFID Screen (NIAS) between a sample of autistic adults (n?=?248) who self-disclosed their diagnosis and a comparison general sample (n?=?398). There was support for strong measurement invariance (configural, metric, and scalar) on the NIAS. Autistic adults scored significantly higher on each of the three subscales: selective eating (d?=?0.54), appetite impairment (d?=?0.27), and fear-driven avoidance of eating (d?=?0.37). The NIAS is a valid instrument for measuring ARFID symptomatology in autistic adults. Autistic adults experience elevated symptomatology across all three ARFID eating restrictions. Future research should address whether evidence-based ARFID treatments are efficacious for autistic adults or need to be modified. En ligne : https://doi.org/10.1002/aur.70039 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Screening for Avoidant/Restrictive Food Intake Disorder Symptoms Among Autistic Adults: Measurement Invariance With a Comparison General Sample [Texte imprimé et/ou numérique] / Goldie A. MCQUAID, Auteur ; Gregory L. WALLACE, Auteur ; Hana F. ZICKGRAF, Auteur . - p.1381-1388. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1381-1388 Mots-clés : adults  autism spectrum disorder  avoidant/restrictive food intake disorder  general population  measurement invariance Index. décimale : PER Périodiques Résumé : ABSTRACT Research suggests a higher prevalence of avoidant/restrictive food intake disorder (ARFID) in autistic people across the lifespan compared to the general population. However, ARFID symptoms in autistic people may be misattributed to core autistic traits and gastrointestinal symptoms that often co-occur with autism. This diagnostic overshadowing could lead to the under-recognition and under-treatment of modifiable symptoms of psychopathology in autistic people. Validating ARFID symptom measures in this population is essential to screening for ARFID and tracking treatment outcomes in this population. Multigroup confirmatory factor analysis was used to evaluate the equivalence of the factor structure, factor loadings, and item intercepts of the Nine-Item ARFID Screen (NIAS) between a sample of autistic adults (n?=?248) who self-disclosed their diagnosis and a comparison general sample (n?=?398). There was support for strong measurement invariance (configural, metric, and scalar) on the NIAS. Autistic adults scored significantly higher on each of the three subscales: selective eating (d?=?0.54), appetite impairment (d?=?0.27), and fear-driven avoidance of eating (d?=?0.37). The NIAS is a valid instrument for measuring ARFID symptomatology in autistic adults. Autistic adults experience elevated symptomatology across all three ARFID eating restrictions. Future research should address whether evidence-based ARFID treatments are efficacious for autistic adults or need to be modified. En ligne : https://doi.org/10.1002/aur.70039 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Sleep-Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions / Ana María GARCÍA-MUÑOZ ; María Luisa Sánchez DE OCAÑA-MORENO ; Amanda L. RICHDALE ; Laura GISBERT-GUSTEMPS ; Jorge LUGO-MARÍN ; Beatriz RODRÍGUEZ-MORILLAS ; Ana María PEIRÓ-PEIRÓ ; Desirée VICTORIA-MONTESINOS ; Cristina LÓPEZ-ANGUAS ; María Dolores MESEGUER-ILLÁN ; Pura BALLESTER-NAVARRO in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1369-1380 Titre : Sleep-Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Ana María GARCÍA-MUÑOZ, Auteur ; María Luisa Sánchez DE OCAÑA-MORENO, Auteur ; Amanda L. RICHDALE, Auteur ; Laura GISBERT-GUSTEMPS, Auteur ; Jorge LUGO-MARÍN, Auteur ; Beatriz RODRÍGUEZ-MORILLAS, Auteur ; Ana María PEIRÓ-PEIRÓ, Auteur ; Desirée VICTORIA-MONTESINOS, Auteur ; Cristina LÓPEZ-ANGUAS, Auteur ; María Dolores MESEGUER-ILLÁN, Auteur ; Pura BALLESTER-NAVARRO, Auteur Article en page(s) : p.1369-1380 Langues : Anglais (eng) Mots-clés : age  ambulatory circadian monitoring  autism spectrum disorder  intellectual disability  sleep problems Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep problems among individuals with autism spectrum disorder (ASD) are a persistent issue that spans from early childhood to adulthood. The present study aimed to objectively investigate sleep continuity and alignment using ambulatory circadian monitoring (ACM) in a group of autistic individuals, with and without intellectual disabilities. We studied 214 participants. Sleep continuity and alignment were assessed using a minimum of 3?days of ACM. Participants were divided into four groups: (1) age? En ligne : https://doi.org/10.1002/aur.70058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Sleep-Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions [Texte imprimé et/ou numérique] / Ana María GARCÍA-MUÑOZ, Auteur ; María Luisa Sánchez DE OCAÑA-MORENO, Auteur ; Amanda L. RICHDALE, Auteur ; Laura GISBERT-GUSTEMPS, Auteur ; Jorge LUGO-MARÍN, Auteur ; Beatriz RODRÍGUEZ-MORILLAS, Auteur ; Ana María PEIRÓ-PEIRÓ, Auteur ; Desirée VICTORIA-MONTESINOS, Auteur ; Cristina LÓPEZ-ANGUAS, Auteur ; María Dolores MESEGUER-ILLÁN, Auteur ; Pura BALLESTER-NAVARRO, Auteur . - p.1369-1380. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1369-1380 Mots-clés : age  ambulatory circadian monitoring  autism spectrum disorder  intellectual disability  sleep problems Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep problems among individuals with autism spectrum disorder (ASD) are a persistent issue that spans from early childhood to adulthood. The present study aimed to objectively investigate sleep continuity and alignment using ambulatory circadian monitoring (ACM) in a group of autistic individuals, with and without intellectual disabilities. We studied 214 participants. Sleep continuity and alignment were assessed using a minimum of 3?days of ACM. Participants were divided into four groups: (1) age? En ligne : https://doi.org/10.1002/aur.70058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Changes in Early Aperiodic EEG Activity Are Linked to Autism Diagnosis and Language Development in Infants With Family History of Autism / Haerin CHUNG ; Amy DAVE ; Helen TAGER-FLUSBERG ; Charles A. NELSON in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1356-1368 Titre : Changes in Early Aperiodic EEG Activity Are Linked to Autism Diagnosis and Language Development in Infants With Family History of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Haerin CHUNG, Auteur ; Amy DAVE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Charles A. NELSON, Auteur Article en page(s) : p.1356-1368 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of language delays, the neurobiology underlying such language challenges remains unclear. Prior research has shown reduced EEG power across multiple frequency bands in 3-to-6-month-old infants with an autistic sibling, followed by accelerated increases in power with age. In this study, we decompose the power spectra into aperiodic (broad band neural firing) and periodic (oscillations) activity to explore possible links between aperiodic changes in the first year of life and later language outcomes. Combining EEG data across two longitudinal studies of infants with and without autistic siblings, we assessed whether infants with an elevated familial likelihood (EFL) exhibit altered changes in both periodic and aperiodic EEG activity at 3 and 12?months of age, compared to those with a low likelihood (LL), and whether developmental change in activity is associated with language development. At 3?months of age (n?=?LL 59, EFL 57), we observed that EFL infants have significantly lower aperiodic activity from 6.7 to 55?Hz (p? En ligne : https://doi.org/10.1002/aur.70063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Changes in Early Aperiodic EEG Activity Are Linked to Autism Diagnosis and Language Development in Infants With Family History of Autism [Texte imprimé et/ou numérique] / Haerin CHUNG, Auteur ; Amy DAVE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Charles A. NELSON, Auteur . - p.1356-1368. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1356-1368 Index. décimale : PER Périodiques Résumé : ABSTRACT Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of language delays, the neurobiology underlying such language challenges remains unclear. Prior research has shown reduced EEG power across multiple frequency bands in 3-to-6-month-old infants with an autistic sibling, followed by accelerated increases in power with age. In this study, we decompose the power spectra into aperiodic (broad band neural firing) and periodic (oscillations) activity to explore possible links between aperiodic changes in the first year of life and later language outcomes. Combining EEG data across two longitudinal studies of infants with and without autistic siblings, we assessed whether infants with an elevated familial likelihood (EFL) exhibit altered changes in both periodic and aperiodic EEG activity at 3 and 12?months of age, compared to those with a low likelihood (LL), and whether developmental change in activity is associated with language development. At 3?months of age (n?=?LL 59, EFL 57), we observed that EFL infants have significantly lower aperiodic activity from 6.7 to 55?Hz (p? En ligne : https://doi.org/10.1002/aur.70063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition / Yong REN ; Kin Wai TAM ; Megan CONROW-GRAHAM ; Zhen YAN in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1342-1355 Titre : Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition Type de document : Texte imprimé et/ou numérique Auteurs : Yong REN, Auteur ; Kin Wai TAM, Auteur ; Megan CONROW-GRAHAM, Auteur ; Zhen YAN, Auteur Article en page(s) : p.1342-1355 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT ADNP (Activity-dependent neuroprotective protein) is a top-ranking autism risk gene. Here we examined synaptic alterations in heterozygous mice carrying an autism mutation on Adnp C-terminus (Adnpmut). We found that PFC pyramidal neurons in Adnpmut mice exhibited significantly diminished glutamatergic and GABAergic synaptic transmission, as indicated by markedly reduced excitatory postsynaptic currents (EPSC) and inhibitory postsynaptic currents (IPSC). Given the key role of ADNP in chromatin regulation and the constitutive association of the ADNP complex with lysine-specific demethylase 1 (LSD1), we examined the therapeutic effects of LSD1 inhibition in Adnpmut mice. We found that treatment with an LSD1 inhibitor significantly elevated EPSC and IPSC in PFC pyramidal neurons of Adnpmut mice, and the rescuing effect was particularly prominent in females. Biochemical assays revealed increased H3K4me2 and decreased H3K9me2/3 by LSD1 inhibitor treatment in female Adnpmut mice, which were correlated with the elevated expression of synaptic genes linked to glutamatergic and GABAergic transmission after the treatment. These data have revealed synaptic deficits in PFC induced by a loss-of-function mutation of Adnp and uncovered the therapeutic potential of LSD1 inhibition in ADNP-deficient conditions, especially for females. En ligne : https://doi.org/10.1002/aur.70069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition [Texte imprimé et/ou numérique] / Yong REN, Auteur ; Kin Wai TAM, Auteur ; Megan CONROW-GRAHAM, Auteur ; Zhen YAN, Auteur . - p.1342-1355. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1342-1355 Index. décimale : PER Périodiques Résumé : ABSTRACT ADNP (Activity-dependent neuroprotective protein) is a top-ranking autism risk gene. Here we examined synaptic alterations in heterozygous mice carrying an autism mutation on Adnp C-terminus (Adnpmut). We found that PFC pyramidal neurons in Adnpmut mice exhibited significantly diminished glutamatergic and GABAergic synaptic transmission, as indicated by markedly reduced excitatory postsynaptic currents (EPSC) and inhibitory postsynaptic currents (IPSC). Given the key role of ADNP in chromatin regulation and the constitutive association of the ADNP complex with lysine-specific demethylase 1 (LSD1), we examined the therapeutic effects of LSD1 inhibition in Adnpmut mice. We found that treatment with an LSD1 inhibitor significantly elevated EPSC and IPSC in PFC pyramidal neurons of Adnpmut mice, and the rescuing effect was particularly prominent in females. Biochemical assays revealed increased H3K4me2 and decreased H3K9me2/3 by LSD1 inhibitor treatment in female Adnpmut mice, which were correlated with the elevated expression of synaptic genes linked to glutamatergic and GABAergic transmission after the treatment. These data have revealed synaptic deficits in PFC induced by a loss-of-function mutation of Adnp and uncovered the therapeutic potential of LSD1 inhibition in ADNP-deficient conditions, especially for females. En ligne : https://doi.org/10.1002/aur.70069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data / Seung-Woo YANG ; Sohee LEE ; Kwang-Sig LEE ; Ki Hoon AHN in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1330-1341 Titre : Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data Type de document : Texte imprimé et/ou numérique Auteurs : Seung-Woo YANG, Auteur ; Sohee LEE, Auteur ; Kwang-Sig LEE, Auteur ; Ki Hoon AHN, Auteur Article en page(s) : p.1330-1341 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  machine learning  risk factors  sex Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder influenced by genetic, epigenetic, and environmental factors. ASD is characterized by a higher prevalence in males compared to females, highlighting the potential role of sex-specific risk factors in its development. This study aimed to develop sex-specific prenatal and perinatal prediction models for ASD using machine learning and a national population database. A retrospective cohort design was employed, utilizing data from the Korea National Health Insurance Service claims database. The study included 75,105 children born as singletons in 2007 and their mothers, with follow-up data from 2007 to 2021. Twenty prenatal and perinatal risk factors from 2002 to 2007 were analyzed. Random forest models were used to predict ASD, with performance metrics including accuracy and area under the curve (AUC). Random forest variable importance and SHapley Additive exPlanation (SHAP) values were used to identify major predictors and analyze associations. The random forest models achieved high accuracy (0.996) and AUC (0.997) for the total population as well as for the male and female groups. Major predictors included pregestational body mass index (BMI) (0.3679), socioeconomic status (0.2164), maternal age at birth (0.1735), sex (0.0682), and delivery institution (0.0549). SHAP analysis showed that low maternal BMI increased ASD risk in both sexes, while high BMI was associated with greater risk in females. A U-shaped relationship between socioeconomic status and ASD risk was observed, with increased risk in males from lower socioeconomic backgrounds and females from higher ones. These findings highlight the importance of sex-specific risk factors, particularly pregestational BMI, and socioeconomic status, in predicting ASD risk. En ligne : https://doi.org/10.1002/aur.70054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data [Texte imprimé et/ou numérique] / Seung-Woo YANG, Auteur ; Sohee LEE, Auteur ; Kwang-Sig LEE, Auteur ; Ki Hoon AHN, Auteur . - p.1330-1341. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1330-1341 Mots-clés : autism spectrum disorder  machine learning  risk factors  sex Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder influenced by genetic, epigenetic, and environmental factors. ASD is characterized by a higher prevalence in males compared to females, highlighting the potential role of sex-specific risk factors in its development. This study aimed to develop sex-specific prenatal and perinatal prediction models for ASD using machine learning and a national population database. A retrospective cohort design was employed, utilizing data from the Korea National Health Insurance Service claims database. The study included 75,105 children born as singletons in 2007 and their mothers, with follow-up data from 2007 to 2021. Twenty prenatal and perinatal risk factors from 2002 to 2007 were analyzed. Random forest models were used to predict ASD, with performance metrics including accuracy and area under the curve (AUC). Random forest variable importance and SHapley Additive exPlanation (SHAP) values were used to identify major predictors and analyze associations. The random forest models achieved high accuracy (0.996) and AUC (0.997) for the total population as well as for the male and female groups. Major predictors included pregestational body mass index (BMI) (0.3679), socioeconomic status (0.2164), maternal age at birth (0.1735), sex (0.0682), and delivery institution (0.0549). SHAP analysis showed that low maternal BMI increased ASD risk in both sexes, while high BMI was associated with greater risk in females. A U-shaped relationship between socioeconomic status and ASD risk was observed, with increased risk in males from lower socioeconomic backgrounds and females from higher ones. These findings highlight the importance of sex-specific risk factors, particularly pregestational BMI, and socioeconomic status, in predicting ASD risk. En ligne : https://doi.org/10.1002/aur.70054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Facial Expression Databases and Autism Spectrum Disorder: A Scoping Review / Braj BHUSHAN in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1314-1329 Titre : Facial Expression Databases and Autism Spectrum Disorder: A Scoping Review Type de document : Texte imprimé et/ou numérique Auteurs : Braj BHUSHAN, Auteur Article en page(s) : p.1314-1329 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  database  emotion recognition  intervention Index. décimale : PER Périodiques Résumé : ABSTRACT Emotion recognition (ER) deficit in autism spectrum disorder (ASD) is widely accepted, and a variety of research was done to assess the deficit in ER under various conditions and intervention research to augment emotion recognition in mostly children with ASD. This scoping review attempted to summarize the diverse research in the context of ER in ASD with a focus on the facial expression databases used for research and intervention. PRISMA-ScR guidelines were followed, and 80 studies were selected after a search from electronic research databases like Web of Science and PubMed with predefined inclusion and exclusion criteria. The trends indicate a small sample size with mostly children as a sample and the ASD group with their matched counterparts. The results show mixed findings; the majority of work indicates a deficit in facial emotion recognition in ASD, but under certain stimuli and conditions, ASD performs well in facial emotion recognition. The interventions showed promising results with increased ER ability in children with ASD. The review also focused on the moderating factors in the study of ER, such as age, IQ, comorbidity, task paradigm, and cultural factors. A small subset of facial expression databases was widely used in the research and intervention, and it has been developed and validated in Western countries. Research gaps were highlighted, and recommendations for future directions were mentioned. En ligne : https://doi.org/10.1002/aur.70030 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Facial Expression Databases and Autism Spectrum Disorder: A Scoping Review [Texte imprimé et/ou numérique] / Braj BHUSHAN, Auteur . - p.1314-1329. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1314-1329 Mots-clés : autism spectrum disorder  database  emotion recognition  intervention Index. décimale : PER Périodiques Résumé : ABSTRACT Emotion recognition (ER) deficit in autism spectrum disorder (ASD) is widely accepted, and a variety of research was done to assess the deficit in ER under various conditions and intervention research to augment emotion recognition in mostly children with ASD. This scoping review attempted to summarize the diverse research in the context of ER in ASD with a focus on the facial expression databases used for research and intervention. PRISMA-ScR guidelines were followed, and 80 studies were selected after a search from electronic research databases like Web of Science and PubMed with predefined inclusion and exclusion criteria. The trends indicate a small sample size with mostly children as a sample and the ASD group with their matched counterparts. The results show mixed findings; the majority of work indicates a deficit in facial emotion recognition in ASD, but under certain stimuli and conditions, ASD performs well in facial emotion recognition. The interventions showed promising results with increased ER ability in children with ASD. The review also focused on the moderating factors in the study of ER, such as age, IQ, comorbidity, task paradigm, and cultural factors. A small subset of facial expression databases was widely used in the research and intervention, and it has been developed and validated in Western countries. Research gaps were highlighted, and recommendations for future directions were mentioned. En ligne : https://doi.org/10.1002/aur.70030 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565