Behavior problems among school-aged children with autism spectrum disorder: Associations with children's communication difficulties and parenting behaviors / Hannah BOONEN in Research in Autism Spectrum Disorders, 8-6 (June 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-6 (June 2014) . - p.716-725 Titre : Behavior problems among school-aged children with autism spectrum disorder: Associations with children's communication difficulties and parenting behaviors Type de document : texte imprimé Auteurs : Hannah BOONEN, Auteur ; Jarymke MALJAARS, Auteur ; Greet LAMBRECHTS, Auteur ; Inge ZINK, Auteur ; Karla VAN LEEUWEN, Auteur ; Ilse NOENS, Auteur Article en page(s) : p.716-725 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Externalizing behavior problems  Internalizing behavior problems  Communication difficulties  Parenting behaviors Index. décimale : PER Périodiques Résumé : Research has clearly demonstrated that behavior problems are common among children with ASD. These co-occurring behavior problems place children with ASD and their families at risk for a range of negative outcomes. This questionnaire study aimed to investigate whether and how age, gender, and communication difficulties at the child level and parenting behaviors at the family level are associated with externalizing and internalizing problems among children with ASD (n = 206) and without ASD (n = 187) aged 6–12 years. Results indicated that pragmatic language difficulties of the child and negative controlling parenting behaviors both made a significant and unique contribution to externalizing behavior problems for the ASD group. In the control group, chronological age and pragmatic language difficulties were the most robust concurrent predictors of externalizing problems. With regard to internalizing problems, pragmatic language difficulties and ASD adapted parenting behaviors were significant predictors for both the ASD and control group. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Behavior problems among school-aged children with autism spectrum disorder: Associations with children's communication difficulties and parenting behaviors [texte imprimé] / Hannah BOONEN, Auteur ; Jarymke MALJAARS, Auteur ; Greet LAMBRECHTS, Auteur ; Inge ZINK, Auteur ; Karla VAN LEEUWEN, Auteur ; Ilse NOENS, Auteur . - p.716-725. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-6 (June 2014) . - p.716-725 Mots-clés : Autism spectrum disorder  Externalizing behavior problems  Internalizing behavior problems  Communication difficulties  Parenting behaviors Index. décimale : PER Périodiques Résumé : Research has clearly demonstrated that behavior problems are common among children with ASD. These co-occurring behavior problems place children with ASD and their families at risk for a range of negative outcomes. This questionnaire study aimed to investigate whether and how age, gender, and communication difficulties at the child level and parenting behaviors at the family level are associated with externalizing and internalizing problems among children with ASD (n = 206) and without ASD (n = 187) aged 6–12 years. Results indicated that pragmatic language difficulties of the child and negative controlling parenting behaviors both made a significant and unique contribution to externalizing behavior problems for the ASD group. In the control group, chronological age and pragmatic language difficulties were the most robust concurrent predictors of externalizing problems. With regard to internalizing problems, pragmatic language difficulties and ASD adapted parenting behaviors were significant predictors for both the ASD and control group. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

Developmental milestones and cognitive trajectories in school-aged children with 16p11.2 deletion / Jente VERBESSELT in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Developmental milestones and cognitive trajectories in school-aged children with 16p11.2 deletion Type de document : texte imprimé Auteurs : Jente VERBESSELT, Auteur ; Jeroen BRECKPOT, Auteur ; Inge ZINK, Auteur ; Ann SWILLEN, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Adolescent  Female  Male  Chromosomes, Human, Pair 16/genetics  Child, Preschool  Intellectual Disability/physiopathology/genetics  Longitudinal Studies  Chromosome Deletion  Chromosome Disorders/physiopathology/complications/genetics  Intelligence  Cognition/physiology  Child Development/physiology  Developmental Disabilities/genetics/physiopathology  Fecal Incontinence/physiopathology  Intelligence Tests  Autistic Disorder  16p11.2 deletion syndrome  Cognition  Copy number variants  Deep phenotyping  Developmental trajectories  Early development  in accordance with the Declaration of Helsinki and approved by the Ethics  Committee Research of University Hospitals Leuven (protocol code S54485, 6  December 2012 and 26 March 2021). Patients and their parents were directly  informed about the aims of the research project, and all participants signed  informed consent. Consent for publication: Not applicable. Competing interests:  The authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: 16p11.2 deletion syndrome (16p11.2DS) is a recurrent CNV that occurs de novo in approximately 70% of cases and confers risk for neurodevelopmental disorders, including intellectual disability (ID) and autism spectrum disorders (ASD). The current study focusses on developmental milestones, cognitive profiles and longitudinal cognitive trajectories. METHODS: In-person assessments, digital medical records and parental interviews on developmental history of 24 children (5-16 years) with a confirmed BP4-BP5 16p11.2DS were reviewed and analysed for developmental milestones (motor, language, continence). Standardised intelligence tests were administered in all children, and longitudinal IQ-data were available for a subgroup (79%, 19/24). RESULTS: Motor, language, and continence milestones were delayed. Average IQ was in the borderline range (IQ 71) with 46% (11/24) having borderline IQ (IQ 70-84). Both intra- and interindividual variability were found across the five cognitive domains with significant discrepancies between verbal and non-verbal skills in 55% (11/20). Longitudinal IQ-data indicate that school-aged children with 16p11.2DS perform statistically significantly lower at the second time point (p < 0.001) with 58% showing a growing into deficit trajectory. CONCLUSION: Delayed motor, language and continence milestones are common in 16p11.2DS carriers. School-aged children with 16p11.2DS show increasing cognitive impairments over time, pointing to the need for early diagnosis, regular cognitive follow-up and individualised intervention. The high prevalence of disharmonic IQ-profiles highlights the importance of expanding the focus beyond full-scale IQ (FSIQ) outcomes. Future studies in larger cohorts including carrier relatives are needed to gain more insight into the penetrance and phenotypic variability of 16p11.2DS. En ligne : https://dx.doi.org/10.1186/s11689-025-09615-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Developmental milestones and cognitive trajectories in school-aged children with 16p11.2 deletion [texte imprimé] / Jente VERBESSELT, Auteur ; Jeroen BRECKPOT, Auteur ; Inge ZINK, Auteur ; Ann SWILLEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Child  Adolescent  Female  Male  Chromosomes, Human, Pair 16/genetics  Child, Preschool  Intellectual Disability/physiopathology/genetics  Longitudinal Studies  Chromosome Deletion  Chromosome Disorders/physiopathology/complications/genetics  Intelligence  Cognition/physiology  Child Development/physiology  Developmental Disabilities/genetics/physiopathology  Fecal Incontinence/physiopathology  Intelligence Tests  Autistic Disorder  16p11.2 deletion syndrome  Cognition  Copy number variants  Deep phenotyping  Developmental trajectories  Early development  in accordance with the Declaration of Helsinki and approved by the Ethics  Committee Research of University Hospitals Leuven (protocol code S54485, 6  December 2012 and 26 March 2021). Patients and their parents were directly  informed about the aims of the research project, and all participants signed  informed consent. Consent for publication: Not applicable. Competing interests:  The authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: 16p11.2 deletion syndrome (16p11.2DS) is a recurrent CNV that occurs de novo in approximately 70% of cases and confers risk for neurodevelopmental disorders, including intellectual disability (ID) and autism spectrum disorders (ASD). The current study focusses on developmental milestones, cognitive profiles and longitudinal cognitive trajectories. METHODS: In-person assessments, digital medical records and parental interviews on developmental history of 24 children (5-16 years) with a confirmed BP4-BP5 16p11.2DS were reviewed and analysed for developmental milestones (motor, language, continence). Standardised intelligence tests were administered in all children, and longitudinal IQ-data were available for a subgroup (79%, 19/24). RESULTS: Motor, language, and continence milestones were delayed. Average IQ was in the borderline range (IQ 71) with 46% (11/24) having borderline IQ (IQ 70-84). Both intra- and interindividual variability were found across the five cognitive domains with significant discrepancies between verbal and non-verbal skills in 55% (11/20). Longitudinal IQ-data indicate that school-aged children with 16p11.2DS perform statistically significantly lower at the second time point (p < 0.001) with 58% showing a growing into deficit trajectory. CONCLUSION: Delayed motor, language and continence milestones are common in 16p11.2DS carriers. School-aged children with 16p11.2DS show increasing cognitive impairments over time, pointing to the need for early diagnosis, regular cognitive follow-up and individualised intervention. The high prevalence of disharmonic IQ-profiles highlights the importance of expanding the focus beyond full-scale IQ (FSIQ) outcomes. Future studies in larger cohorts including carrier relatives are needed to gain more insight into the penetrance and phenotypic variability of 16p11.2DS. En ligne : https://dx.doi.org/10.1186/s11689-025-09615-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Exploring receptive and expressive language components at the age of 36 months in siblings at risk for autism spectrum disorder / Eva BRUYNEEL in Research in Autism Spectrum Disorders, 66 (October 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 66 (October 2019) . - p.101419 Titre : Exploring receptive and expressive language components at the age of 36 months in siblings at risk for autism spectrum disorder Type de document : texte imprimé Auteurs : Eva BRUYNEEL, Auteur ; Ellen DEMURIE, Auteur ; Inge ZINK, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.101419 Langues : Anglais (eng) Mots-clés : Receptive language  Expressive language  Language components  High-risk siblings  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Language difficulties are highly prevalent in children with autism spectrum disorder (ASD) as well as in their younger siblings (high-risk (HR) sibs). Children with ASD show substantial heterogeneity in difficulties with different language components, but it remains unknown whether this variability is also present in HR-sibs. Method Receptive (RL) and expressive language (EL) were evaluated in siblings of typically developing children (low-risk (LR) sibs, N = 33) and HR-sibs (N = 30) at 36 months, using the Mullen Scales of Early Learning (MSEL), the Dutch version of the Reynell Developmental Language Scales – 2nd edition (RDLS-2) and spontaneous language analysis (SL). Next, composite scores for receptive and expressive phonology, grammar, semantics and pragmatics were formed. Group comparisons were performed and delays in the different language components were explored. Results En ligne : https://doi.org/10.1016/j.rasd.2019.101419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 [article] Exploring receptive and expressive language components at the age of 36 months in siblings at risk for autism spectrum disorder [texte imprimé] / Eva BRUYNEEL, Auteur ; Ellen DEMURIE, Auteur ; Inge ZINK, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - p.101419. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 66 (October 2019) . - p.101419 Mots-clés : Receptive language  Expressive language  Language components  High-risk siblings  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Language difficulties are highly prevalent in children with autism spectrum disorder (ASD) as well as in their younger siblings (high-risk (HR) sibs). Children with ASD show substantial heterogeneity in difficulties with different language components, but it remains unknown whether this variability is also present in HR-sibs. Method Receptive (RL) and expressive language (EL) were evaluated in siblings of typically developing children (low-risk (LR) sibs, N = 33) and HR-sibs (N = 30) at 36 months, using the Mullen Scales of Early Learning (MSEL), the Dutch version of the Reynell Developmental Language Scales – 2nd edition (RDLS-2) and spontaneous language analysis (SL). Next, composite scores for receptive and expressive phonology, grammar, semantics and pragmatics were formed. Group comparisons were performed and delays in the different language components were explored. Results En ligne : https://doi.org/10.1016/j.rasd.2019.101419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404

Mothers’ Parenting Behaviors in Families of School-Aged Children with Autism Spectrum Disorder: An Observational and Questionnaire Study / Hannah BOONEN in Journal of Autism and Developmental Disorders, 45-11 (November 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3580-3593 Titre : Mothers’ Parenting Behaviors in Families of School-Aged Children with Autism Spectrum Disorder: An Observational and Questionnaire Study Type de document : texte imprimé Auteurs : Hannah BOONEN, Auteur ; Lotte VAN ESCH, Auteur ; Greet LAMBRECHTS, Auteur ; Jarymke MALJAARS, Auteur ; Inge ZINK, Auteur ; Karla VAN LEEUWEN, Auteur ; Ilse NOENS, Auteur Article en page(s) : p.3580-3593 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Parenting behaviors  Observation  Questionnaire  Parenting stress Index. décimale : PER Périodiques Résumé : Although parents of children with ASD face specific challenges in parenting, only a few studies have empirically investigated parenting behaviors among these parents. The current study examined differences in parenting behaviors between mothers of school-aged children with ASD (n = 30) and mothers of typically developing children (n = 39), using both an observational measure and a self-report questionnaire. Results indicated that mothers of children with ASD obtained significantly lower scores on Sensitivity and Provision of structure as measured during the observation. They reported significantly higher scores on Material rewarding and Adapting the environment on the questionnaire. When controlling for parenting stress, the group differences on Sensitivity and Material rewarding did not remain significant. En ligne : http://dx.doi.org/10.1007/s10803-015-2506-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Mothers’ Parenting Behaviors in Families of School-Aged Children with Autism Spectrum Disorder: An Observational and Questionnaire Study [texte imprimé] / Hannah BOONEN, Auteur ; Lotte VAN ESCH, Auteur ; Greet LAMBRECHTS, Auteur ; Jarymke MALJAARS, Auteur ; Inge ZINK, Auteur ; Karla VAN LEEUWEN, Auteur ; Ilse NOENS, Auteur . - p.3580-3593. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3580-3593 Mots-clés : Autism spectrum disorder  Parenting behaviors  Observation  Questionnaire  Parenting stress Index. décimale : PER Périodiques Résumé : Although parents of children with ASD face specific challenges in parenting, only a few studies have empirically investigated parenting behaviors among these parents. The current study examined differences in parenting behaviors between mothers of school-aged children with ASD (n = 30) and mothers of typically developing children (n = 39), using both an observational measure and a self-report questionnaire. Results indicated that mothers of children with ASD obtained significantly lower scores on Sensitivity and Provision of structure as measured during the observation. They reported significantly higher scores on Material rewarding and Adapting the environment on the questionnaire. When controlling for parenting stress, the group differences on Sensitivity and Material rewarding did not remain significant. En ligne : http://dx.doi.org/10.1007/s10803-015-2506-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Problem behavior in young children referred with language difficulties: Relations to language and intentional communication / Rianne JANSEN in Autism & Developmental Language Impairments, 5 (January-December 2020)  

Public ISBD [article]  inAutism & Developmental Language Impairments > 5 (January-December 2020) Titre : Problem behavior in young children referred with language difficulties: Relations to language and intentional communication Type de document : texte imprimé Auteurs : Rianne JANSEN, Auteur ; Jarymke MALJAARS, Auteur ; Anouk VERHAPPEN, Auteur ; Inge ZINK, Auteur ; Jean STEYAERT, Auteur ; Ilse NOENS, Auteur Langues : Anglais (eng) Mots-clés : Language difficulties  intentional communication  problem behavior  early childhood Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/2396941519900076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Problem behavior in young children referred with language difficulties: Relations to language and intentional communication [texte imprimé] / Rianne JANSEN, Auteur ; Jarymke MALJAARS, Auteur ; Anouk VERHAPPEN, Auteur ; Inge ZINK, Auteur ; Jean STEYAERT, Auteur ; Ilse NOENS, Auteur. Langues : Anglais (eng) in Autism & Developmental Language Impairments > 5 (January-December 2020) Mots-clés : Language difficulties  intentional communication  problem behavior  early childhood Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/2396941519900076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

The complexity of early diagnostic decision making: A follow-up study of young children with language difficulties / Rianne JANSEN in Autism & Developmental Language Impairments, 6 (January-December 2021)  

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