Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism / J. J. WOLFF in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 8p. Titre : Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism Type de document : Texte imprimé et/ou numérique Auteurs : J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; J. T. ELISON, Auteur ; G. GERIG, Auteur ; J. R. PRUETT, Auteur ; M. A. STYNER, Auteur ; C. VACHET, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; M. D. SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur Article en page(s) : 8p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/*psychology  Brain/diagnostic imaging/*physiology  Brain Mapping/*methods  Child, Preschool  Diffusion Tensor Imaging/*methods  Female  Humans  Infant  Longitudinal Studies  Male  Stereotyped Behavior/*physiology  *Autism  *Diffusion tensor imaging  *Infant  *Longitudinal  *Repetitive behavior  *White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli. To date, little is known about the neural circuitry underlying these features of ASD early in life. METHODS: Longitudinal diffusion tensor imaging data were collected from 217 infants at high familial risk for ASD. Forty-four of these infants were diagnosed with ASD at age 2. Targeted cortical, cerebellar, and striatal white matter pathways were defined and measured at ages 6, 12, and 24 months. Dependent variables included the Repetitive Behavior Scale-Revised and the Sensory Experiences Questionnaire. RESULTS: Among children diagnosed with ASD, repetitive behaviors and sensory response patterns were strongly correlated, even when accounting for developmental level or social impairment. Longitudinal analyses indicated that the genu and cerebellar pathways were significantly associated with both repetitive behaviors and sensory responsiveness but not social deficits. At age 6 months, fractional anisotropy in the genu significantly predicted repetitive behaviors and sensory responsiveness at age 2. Cerebellar pathways significantly predicted later sensory responsiveness. Exploratory analyses suggested a possible disordinal interaction based on diagnostic status for the association between fractional anisotropy and repetitive behavior. CONCLUSIONS: Our findings suggest that restricted and repetitive behaviors contributing to a diagnosis of ASD at age 2 years are associated with structural properties of callosal and cerebellar white matter pathways measured during infancy and toddlerhood. We further identified that repetitive behaviors and unusual sensory response patterns co-occur and share common brain-behavior relationships. These results were strikingly specific given the absence of association between targeted pathways and social deficits. En ligne : http://dx.doi.org/10.1186/s13229-017-0126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism [Texte imprimé et/ou numérique] / J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; J. T. ELISON, Auteur ; G. GERIG, Auteur ; J. R. PRUETT, Auteur ; M. A. STYNER, Auteur ; C. VACHET, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; M. D. SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur . - 8p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 8p. Mots-clés : Autism Spectrum Disorder/diagnostic imaging/*psychology  Brain/diagnostic imaging/*physiology  Brain Mapping/*methods  Child, Preschool  Diffusion Tensor Imaging/*methods  Female  Humans  Infant  Longitudinal Studies  Male  Stereotyped Behavior/*physiology  *Autism  *Diffusion tensor imaging  *Infant  *Longitudinal  *Repetitive behavior  *White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli. To date, little is known about the neural circuitry underlying these features of ASD early in life. METHODS: Longitudinal diffusion tensor imaging data were collected from 217 infants at high familial risk for ASD. Forty-four of these infants were diagnosed with ASD at age 2. Targeted cortical, cerebellar, and striatal white matter pathways were defined and measured at ages 6, 12, and 24 months. Dependent variables included the Repetitive Behavior Scale-Revised and the Sensory Experiences Questionnaire. RESULTS: Among children diagnosed with ASD, repetitive behaviors and sensory response patterns were strongly correlated, even when accounting for developmental level or social impairment. Longitudinal analyses indicated that the genu and cerebellar pathways were significantly associated with both repetitive behaviors and sensory responsiveness but not social deficits. At age 6 months, fractional anisotropy in the genu significantly predicted repetitive behaviors and sensory responsiveness at age 2. Cerebellar pathways significantly predicted later sensory responsiveness. Exploratory analyses suggested a possible disordinal interaction based on diagnostic status for the association between fractional anisotropy and repetitive behavior. CONCLUSIONS: Our findings suggest that restricted and repetitive behaviors contributing to a diagnosis of ASD at age 2 years are associated with structural properties of callosal and cerebellar white matter pathways measured during infancy and toddlerhood. We further identified that repetitive behaviors and unusual sensory response patterns co-occur and share common brain-behavior relationships. These results were strikingly specific given the absence of association between targeted pathways and social deficits. En ligne : http://dx.doi.org/10.1186/s13229-017-0126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Offering to Share: How to Put Heads Together in Autism Neuroimaging / Matthew K. BELMONTE in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13 Titre : Offering to Share: How to Put Heads Together in Autism Neuroimaging Type de document : Texte imprimé et/ou numérique Auteurs : Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur Année de publication : 2008 Article en page(s) : p.2-13 Langues : Anglais (eng) Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on. En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315 [article] Offering to Share: How to Put Heads Together in Autism Neuroimaging [Texte imprimé et/ou numérique] / Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur . - 2008 . - p.2-13. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13 Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on. En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315

Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder / A. ESTES in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1122-1132 Titre : Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. ESTES, Auteur ; J. MUNSON, Auteur ; T. S. JOHN, Auteur ; Stephen R. DAGER, Auteur ; A. RODDA, Auteur ; Kelly N. BOTTERON, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; M. J. GURALNICK, Auteur Article en page(s) : p.1122-1132 Langues : Anglais (eng) Mots-clés : Autism  High risk  Parent  Peer relations  Preschool  Sibling Index. décimale : PER Périodiques Résumé : Preschool-aged siblings of children with ASD are at high-risk (HR) for ASD and related challenges, but little is known about their emerging peer competence and friendships. Parents are the main providers of peer-relationship opportunities during preschool. Understanding parental challenges supporting early peer relationships is needed for optimal peer competence and friendships in children with ASD. We describe differences in peer relationships among three groups of preschool-aged children (15 HR-ASD, 53 HR-NonASD, 40 low-risk, LR), and examine parent support activities at home and arranging community-based peer activities. Children with ASD demonstrated precursors to poor peer competence and friendship outcomes. Parents in the HR group showed resilience in many areas, but providing peer opportunities for preschool-age children with ASD demanded significant adaptations. En ligne : http://dx.doi.org/10.1007/s10803-017-3202-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351 [article] Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. ESTES, Auteur ; J. MUNSON, Auteur ; T. S. JOHN, Auteur ; Stephen R. DAGER, Auteur ; A. RODDA, Auteur ; Kelly N. BOTTERON, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; M. J. GURALNICK, Auteur . - p.1122-1132. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1122-1132 Mots-clés : Autism  High risk  Parent  Peer relations  Preschool  Sibling Index. décimale : PER Périodiques Résumé : Preschool-aged siblings of children with ASD are at high-risk (HR) for ASD and related challenges, but little is known about their emerging peer competence and friendships. Parents are the main providers of peer-relationship opportunities during preschool. Understanding parental challenges supporting early peer relationships is needed for optimal peer competence and friendships in children with ASD. We describe differences in peer relationships among three groups of preschool-aged children (15 HR-ASD, 53 HR-NonASD, 40 low-risk, LR), and examine parent support activities at home and arranging community-based peer activities. Children with ASD demonstrated precursors to poor peer competence and friendship outcomes. Parents in the HR group showed resilience in many areas, but providing peer opportunities for preschool-age children with ASD demanded significant adaptations. En ligne : http://dx.doi.org/10.1007/s10803-017-3202-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351

Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder / Adele F. DIMIAN in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1403-1415 Titre : Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Adele F. DIMIAN, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Jed T. ELISON, Auteur ; Annette M. ESTES, Auteur ; John R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Jason J. WOLFF, Auteur Article en page(s) : p.1403-1415 Langues : Anglais (eng) Mots-clés : Self-injurious behavior  Repetitive behavior  Autism spectrum disorder  Risk factors  Infants Index. décimale : PER Périodiques Résumé : Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose of this study was to evaluate behavioral characteristics predicting SIB at age 2 years among 235 infants at high familial risk for ASD. Logistic regression results indicated that presence of SIB or proto-SIB and lower developmental functioning at age 12 months significantly predicted SIB at 24 months. A pattern of persistent SIB over this period was associated with a diagnosis of autism and poorer cognitive and adaptive outcomes. En ligne : http://dx.doi.org/10.1007/s10803-017-3057-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Adele F. DIMIAN, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Jed T. ELISON, Auteur ; Annette M. ESTES, Auteur ; John R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Jason J. WOLFF, Auteur . - p.1403-1415. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1403-1415 Mots-clés : Self-injurious behavior  Repetitive behavior  Autism spectrum disorder  Risk factors  Infants Index. décimale : PER Périodiques Résumé : Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose of this study was to evaluate behavioral characteristics predicting SIB at age 2 years among 235 infants at high familial risk for ASD. Logistic regression results indicated that presence of SIB or proto-SIB and lower developmental functioning at age 12 months significantly predicted SIB at 24 months. A pattern of persistent SIB over this period was associated with a diagnosis of autism and poorer cognitive and adaptive outcomes. En ligne : http://dx.doi.org/10.1007/s10803-017-3057-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder / Neva M. CORRIGAN in Journal of Autism and Developmental Disorders, 42-1 (January 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115 Titre : Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur Année de publication : 2012 Article en page(s) : p.105-115 Langues : Anglais (eng) Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain metabolism  Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur . - 2012 . - p.105-115. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115 Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain metabolism  Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Relations of Restricted and Repetitive Behaviors to Social Skills in Toddlers with Autism / Pang CHAXIONG in Journal of Autism and Developmental Disorders, 52-4 (April 2022)  

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Sensory Profiles in Relation to Later Adaptive Functioning Among Toddlers at High-Familial Likelihood for Autism / Emma WORTHLEY in Journal of Autism and Developmental Disorders, 54-6 (June 2024)  

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Social and non-social sensory responsivity in toddlers at high-risk for autism spectrum disorder / J. GUNDERSON in Autism Research, 14-10 (October 2021)  

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Social motivation in infancy is associated with familial recurrence of ASD / Natasha MARRUS in Development and Psychopathology, 36-1 (February 2024)  

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Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in autism spectrum disorder / Natalia M. KLEINHANS in Autism Research, 9-7 (July 2016)  

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The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism / Kristen LYALL in Autism Research, 13-6 (June 2020)  

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The Importance of Temperament for Understanding Early Manifestations of Autism Spectrum Disorder in High-Risk Infants / Sarah J. PATERSON in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

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The prevalence and developmental course of auditory processing differences in autistic children / Bonnie K. LAU in Autism Research, 16-7 (July 2023)  

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