Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder / J. KERR-GAFFNEY in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 47 p. Titre : Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. KERR-GAFFNEY, Auteur ; H. HAYWARD, Auteur ; E. J. H. JONES, Auteur ; D. HALLS, Auteur ; D. MURPHY, Auteur ; K. TCHANTURIA, Auteur Article en page(s) : 47 p. Langues : Anglais (eng) Mots-clés : Anorexia nervosa  Autism diagnostic observation schedule  Autism spectrum disorder  Comorbidity  Diagnosis  Screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent research suggests a link between autism spectrum disorder (ASD) and anorexia nervosa (AN). Individuals with AN show high scores on measures of ASD symptoms, relative to individuals without AN, however, there are currently no studies directly comparing women with AN to women with ASD. The aim of the current study was to examine profiles of ASD symptoms in young women in the acute and recovered stages of AN, women with ASD, and typically developing controls (TD), on both self-report and clinical interview measures. METHODS: Four groups of participants aged 12-30 years were included (n?=?218): AN, recovered AN (REC), ASD, and TD. Group differences on the Social Responsiveness Scale, 2nd edition (SRS-2), 10-item Autism Quotient (AQ-10), and the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) were examined. To explore similarities and differences in specific symptom profiles associated with AN and ASD, individual item endorsement on the ADOS-2 was also examined in AN, REC, and ASD. RESULTS: Across measures, women with ASD showed the highest scores, and TDs the lowest. Generally, individuals with AN and REC showed intermediate levels of ASD symptoms, scoring between the other two groups. However, AN and ASD did not differ on restricted interests and repetitive behaviour subscales. The ADOS-2 item 'quality of social response' adequately discriminated between ASD and non-ASD participants. LIMITATIONS: A full diagnostic assessment for ASD was not provided for participants with AN/REC, nor were eating disorders assessed in the ASD group. Therefore, some diagnostic overlap between groups is possible. The cross-sectional design is another limitation. CONCLUSIONS: The results suggest similarities in scores on both self-report and clinical interview measures in AN and ASD. However, individual ADOS-2 item analyses also revealed subtle differences, particularly in reciprocal social interaction. ASD symptoms may be a combination of both state and trait features in AN. En ligne : http://dx.doi.org/10.1186/s13229-021-00455-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder [Texte imprimé et/ou numérique] / J. KERR-GAFFNEY, Auteur ; H. HAYWARD, Auteur ; E. J. H. JONES, Auteur ; D. HALLS, Auteur ; D. MURPHY, Auteur ; K. TCHANTURIA, Auteur . - 47 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 47 p. Mots-clés : Anorexia nervosa  Autism diagnostic observation schedule  Autism spectrum disorder  Comorbidity  Diagnosis  Screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent research suggests a link between autism spectrum disorder (ASD) and anorexia nervosa (AN). Individuals with AN show high scores on measures of ASD symptoms, relative to individuals without AN, however, there are currently no studies directly comparing women with AN to women with ASD. The aim of the current study was to examine profiles of ASD symptoms in young women in the acute and recovered stages of AN, women with ASD, and typically developing controls (TD), on both self-report and clinical interview measures. METHODS: Four groups of participants aged 12-30 years were included (n?=?218): AN, recovered AN (REC), ASD, and TD. Group differences on the Social Responsiveness Scale, 2nd edition (SRS-2), 10-item Autism Quotient (AQ-10), and the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) were examined. To explore similarities and differences in specific symptom profiles associated with AN and ASD, individual item endorsement on the ADOS-2 was also examined in AN, REC, and ASD. RESULTS: Across measures, women with ASD showed the highest scores, and TDs the lowest. Generally, individuals with AN and REC showed intermediate levels of ASD symptoms, scoring between the other two groups. However, AN and ASD did not differ on restricted interests and repetitive behaviour subscales. The ADOS-2 item 'quality of social response' adequately discriminated between ASD and non-ASD participants. LIMITATIONS: A full diagnostic assessment for ASD was not provided for participants with AN/REC, nor were eating disorders assessed in the ASD group. Therefore, some diagnostic overlap between groups is possible. The cross-sectional design is another limitation. CONCLUSIONS: The results suggest similarities in scores on both self-report and clinical interview measures in AN and ASD. However, individual ADOS-2 item analyses also revealed subtle differences, particularly in reciprocal social interaction. ASD symptoms may be a combination of both state and trait features in AN. En ligne : http://dx.doi.org/10.1186/s13229-021-00455-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Autistic Traits Mediate Reductions in Social Attention in Adults with Anorexia Nervosa / J. KERR-GAFFNEY in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2077-2090 Titre : Autistic Traits Mediate Reductions in Social Attention in Adults with Anorexia Nervosa Type de document : Texte imprimé et/ou numérique Auteurs : J. KERR-GAFFNEY, Auteur ; L. MASON, Auteur ; E. JONES, Auteur ; H. HAYWARD, Auteur ; A. HARRISON, Auteur ; D. MURPHY, Auteur ; K. TCHANTURIA, Auteur Article en page(s) : p.2077-2090 Langues : Anglais (eng) Mots-clés : Adult  Affective Symptoms/psychology  Anorexia Nervosa/psychology  Anxiety/psychology  Attention  Autistic Disorder/psychology  Depression/psychology  Emotions  Eye Movements  Facial Recognition  Female  Humans  Male  Self Report  Time Factors  Young Adult  Anorexia nervosa  Autism spectrum disorder  Comorbidity  Eye-tracking  Social attention Index. décimale : PER Périodiques Résumé : Anorexia nervosa (AN) is associated with difficulties in social and emotional functioning. A significant proportion of individuals with AN show autistic traits, which may influence social attention. This study examined attention to faces and facial features in AN, recovered AN (REC), and healthy controls, as well as relationships with comorbid psychopathology. One hundred and forty-eight participants' eye movements were tracked while watching a naturalistic social scene. Anxiety, depression, alexithymia, and autistic traits were assessed via self-report questionnaires. Participants with AN spent significantly less time looking at faces compared to REC and controls; patterns of attention to individual facial features did not differ across groups. Autistic traits mediated the relationship between group and time spent looking at faces. En ligne : http://dx.doi.org/10.1007/s10803-020-04686-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Autistic Traits Mediate Reductions in Social Attention in Adults with Anorexia Nervosa [Texte imprimé et/ou numérique] / J. KERR-GAFFNEY, Auteur ; L. MASON, Auteur ; E. JONES, Auteur ; H. HAYWARD, Auteur ; A. HARRISON, Auteur ; D. MURPHY, Auteur ; K. TCHANTURIA, Auteur . - p.2077-2090. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2077-2090 Mots-clés : Adult  Affective Symptoms/psychology  Anorexia Nervosa/psychology  Anxiety/psychology  Attention  Autistic Disorder/psychology  Depression/psychology  Emotions  Eye Movements  Facial Recognition  Female  Humans  Male  Self Report  Time Factors  Young Adult  Anorexia nervosa  Autism spectrum disorder  Comorbidity  Eye-tracking  Social attention Index. décimale : PER Périodiques Résumé : Anorexia nervosa (AN) is associated with difficulties in social and emotional functioning. A significant proportion of individuals with AN show autistic traits, which may influence social attention. This study examined attention to faces and facial features in AN, recovered AN (REC), and healthy controls, as well as relationships with comorbid psychopathology. One hundred and forty-eight participants' eye movements were tracked while watching a naturalistic social scene. Anxiety, depression, alexithymia, and autistic traits were assessed via self-report questionnaires. Participants with AN spent significantly less time looking at faces compared to REC and controls; patterns of attention to individual facial features did not differ across groups. Autistic traits mediated the relationship between group and time spent looking at faces. En ligne : http://dx.doi.org/10.1007/s10803-020-04686-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Brain hyperserotonemia causes autism-relevant social deficits in mice / M. TANAKA in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 60p. Titre : Brain hyperserotonemia causes autism-relevant social deficits in mice Type de document : Texte imprimé et/ou numérique Auteurs : M. TANAKA, Auteur ; A. SATO, Auteur ; S. KASAI, Auteur ; Y. HAGINO, Auteur ; H. KOTAJIMA-MURAKAMI, Auteur ; H. KASHII, Auteur ; Y. TAKAMATSU, Auteur ; Y. NISHITO, Auteur ; M. INAGAKI, Auteur ; M. MIZUGUCHI, Auteur ; F. S. HALL, Auteur ; G. R. UHL, Auteur ; D. MURPHY, Auteur ; I. SORA, Auteur ; K. IKEDA, Auteur Article en page(s) : 60p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Heterozygous mice  Serotonin transporter  Tryptophan depletion Index. décimale : PER Périodiques Résumé : Background: Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods: We analyzed behavior and gene expression to unveil the causal mechanism of ASD-relevant social deficits using serotonin transporter (Sert) knockout mice. Results: Social deficits were observed in both heterozygous knockout mice (HZ) and homozygous knockout mice (KO), but increases in general anxiety were only observed in KO mice. Two weeks of dietary restriction of the serotonin precursor tryptophan ameliorated both brain hyperserotonemia and ASD-relevant social deficits in Sert HZ and KO mice. The expression of rather distinct sets of genes was altered in Sert HZ and KO mice, and a substantial portion of these genes was also affected by tryptophan depletion. Tryptophan depletion in Sert HZ and KO mice was associated with alterations in the expression of genes involved in signal transduction pathways initiated by changes in extracellular serotonin or melatonin, a derivative of serotonin. Only expression of the AU015836 gene was altered in both Sert HZ and KO mice. AU015836 expression and ASD-relevant social deficits normalized after dietary tryptophan restriction. Conclusions: These findings reveal a Sert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits. En ligne : https://dx.doi.org/10.1186/s13229-018-0243-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Brain hyperserotonemia causes autism-relevant social deficits in mice [Texte imprimé et/ou numérique] / M. TANAKA, Auteur ; A. SATO, Auteur ; S. KASAI, Auteur ; Y. HAGINO, Auteur ; H. KOTAJIMA-MURAKAMI, Auteur ; H. KASHII, Auteur ; Y. TAKAMATSU, Auteur ; Y. NISHITO, Auteur ; M. INAGAKI, Auteur ; M. MIZUGUCHI, Auteur ; F. S. HALL, Auteur ; G. R. UHL, Auteur ; D. MURPHY, Auteur ; I. SORA, Auteur ; K. IKEDA, Auteur . - 60p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 60p. Mots-clés : Autism spectrum disorder  Heterozygous mice  Serotonin transporter  Tryptophan depletion Index. décimale : PER Périodiques Résumé : Background: Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods: We analyzed behavior and gene expression to unveil the causal mechanism of ASD-relevant social deficits using serotonin transporter (Sert) knockout mice. Results: Social deficits were observed in both heterozygous knockout mice (HZ) and homozygous knockout mice (KO), but increases in general anxiety were only observed in KO mice. Two weeks of dietary restriction of the serotonin precursor tryptophan ameliorated both brain hyperserotonemia and ASD-relevant social deficits in Sert HZ and KO mice. The expression of rather distinct sets of genes was altered in Sert HZ and KO mice, and a substantial portion of these genes was also affected by tryptophan depletion. Tryptophan depletion in Sert HZ and KO mice was associated with alterations in the expression of genes involved in signal transduction pathways initiated by changes in extracellular serotonin or melatonin, a derivative of serotonin. Only expression of the AU015836 gene was altered in both Sert HZ and KO mice. AU015836 expression and ASD-relevant social deficits normalized after dietary tryptophan restriction. Conclusions: These findings reveal a Sert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits. En ligne : https://dx.doi.org/10.1186/s13229-018-0243-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors / David G. AMARAL in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.700-714 Titre : Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors Type de document : Texte imprimé et/ou numérique Auteurs : David G. AMARAL, Auteur ; George M. ANDERSON, Auteur ; A. BAILEY, Auteur ; Raphael BERNIER, Auteur ; Somer L. BISHOP, Auteur ; Gene J. BLATT, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Tony CHARMAN, Auteur ; G. DAWSON, Auteur ; P. J. DE VRIES, Auteur ; Emanuel DICICCO-BLOOM, Auteur ; Cheryl DISSANAYAKE, Auteur ; Y. KAMIO, Auteur ; R. KANA, Auteur ; N. Z. KHAN, Auteur ; A. KNOLL, Auteur ; F. KOOY, Auteur ; J. LAINHART, Auteur ; P. LEVITT, Auteur ; K. LOVELAND, Auteur ; N. MINSHEW, Auteur ; R. A. MUELLER, Auteur ; D. MURPHY, Auteur ; Peter C. MUNDY, Auteur ; S. PALENCIA, Auteur ; J. PINTO-MARTIN, Auteur ; A. RATTAZZI, Auteur ; S. ROGERS, Auteur ; W. L. STONE, Auteur ; S. J. WEBB, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.700-714 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors [Texte imprimé et/ou numérique] / David G. AMARAL, Auteur ; George M. ANDERSON, Auteur ; A. BAILEY, Auteur ; Raphael BERNIER, Auteur ; Somer L. BISHOP, Auteur ; Gene J. BLATT, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Tony CHARMAN, Auteur ; G. DAWSON, Auteur ; P. J. DE VRIES, Auteur ; Emanuel DICICCO-BLOOM, Auteur ; Cheryl DISSANAYAKE, Auteur ; Y. KAMIO, Auteur ; R. KANA, Auteur ; N. Z. KHAN, Auteur ; A. KNOLL, Auteur ; F. KOOY, Auteur ; J. LAINHART, Auteur ; P. LEVITT, Auteur ; K. LOVELAND, Auteur ; N. MINSHEW, Auteur ; R. A. MUELLER, Auteur ; D. MURPHY, Auteur ; Peter C. MUNDY, Auteur ; S. PALENCIA, Auteur ; J. PINTO-MARTIN, Auteur ; A. RATTAZZI, Auteur ; S. ROGERS, Auteur ; W. L. STONE, Auteur ; S. J. WEBB, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.700-714. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.700-714 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Needs of Adolescents and Young Adults with Neurodevelopmental Disorders: Comparisons of Young People and Parent Perspectives / H. EKLUND in Journal of Autism and Developmental Disorders, 48-1 (January 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-1 (January 2018) . - p.83-91 Titre : Needs of Adolescents and Young Adults with Neurodevelopmental Disorders: Comparisons of Young People and Parent Perspectives Type de document : Texte imprimé et/ou numérique Auteurs : H. EKLUND, Auteur ; J. FINDON, Auteur ; T. CADMAN, Auteur ; H. HAYWARD, Auteur ; D. MURPHY, Auteur ; Philip ASHERSON, Auteur ; K. GLASER, Auteur ; K. XENITIDIS, Auteur Article en page(s) : p.83-91 Langues : Anglais (eng) Mots-clés : Adhd  Asd  Needs assessment  Neurodevelopmental disorders  Young adulthood Index. décimale : PER Périodiques Résumé : This study used the Camberwell Assessment of Need for adults with Developmental and Intellectual Disabilities (CANDID) to examine the social, physical health and mental health needs of 168 young people (aged 14-24 years) with neurodevelopmental disorders and compared young person and parent ratings of need. Agreement was poor in 21 out of 25 domains. Parents consistently reported higher levels of need than young people in the majority of domains although young people with ADHD reported significantly more needs in physical health, eyesight/hearing, seizures, other mental health problems and safety of others than their parents. Both parent and young person perspectives of needs are necessary to ensure that needs that are predictive of current or future poor outcomes are not missed. En ligne : https://doi.org/10.1007/s10803-017-3295-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Needs of Adolescents and Young Adults with Neurodevelopmental Disorders: Comparisons of Young People and Parent Perspectives [Texte imprimé et/ou numérique] / H. EKLUND, Auteur ; J. FINDON, Auteur ; T. CADMAN, Auteur ; H. HAYWARD, Auteur ; D. MURPHY, Auteur ; Philip ASHERSON, Auteur ; K. GLASER, Auteur ; K. XENITIDIS, Auteur . - p.83-91. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-1 (January 2018) . - p.83-91 Mots-clés : Adhd  Asd  Needs assessment  Neurodevelopmental disorders  Young adulthood Index. décimale : PER Périodiques Résumé : This study used the Camberwell Assessment of Need for adults with Developmental and Intellectual Disabilities (CANDID) to examine the social, physical health and mental health needs of 168 young people (aged 14-24 years) with neurodevelopmental disorders and compared young person and parent ratings of need. Agreement was poor in 21 out of 25 domains. Parents consistently reported higher levels of need than young people in the majority of domains although young people with ADHD reported significantly more needs in physical health, eyesight/hearing, seizures, other mental health problems and safety of others than their parents. Both parent and young person perspectives of needs are necessary to ensure that needs that are predictive of current or future poor outcomes are not missed. En ligne : https://doi.org/10.1007/s10803-017-3295-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers / L. MASON in Molecular Autism, 12 (2021)  

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The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder / C. MANN in Molecular Autism, 9 (2018)  

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The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology / R. KNOTT in Molecular Autism, 12 (2021)  

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