Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder / Kaela E. SCOTT in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1322-1331 Titre : Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kaela E. SCOTT, Auteur ; S. E. SCHULZ, Auteur ; D. MOEHRLE, Auteur ; Brian L. ALLMAN, Auteur ; Janis ORAM CARDY, Auteur ; R. A. STEVENSON, Auteur ; S. SCHMID, Auteur Article en page(s) : p.1322-1331 Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder  Cognition  Evoked Potentials  Humans  Mice  Perception  Sensation  auditory processing  experimental design  framework  sensory phenotypes  species translation Index. décimale : PER Périodiques Résumé : The study of sensory phenotypes has great potential for increasing research translation between species, a necessity to decipher the neural mechanisms that contribute to higher-order differences in neurological conditions such as autism spectrum disorder (ASD). Over the past decade, despite separate advances in our understanding of the structural and functional differences within the brain of autistic and non-autistic individuals and in rodent models for ASD, researchers have had difficulty translating the findings in murine species to humans, mostly due to incompatibility in experimental methodologies used to screen for ASD phenotypes. Focusing on sensory phenotypes offers an avenue to close the species gap because sensory pathways are highly conserved across species and are affected by the same risk-factors as the higher-order brain areas mostly responsible for the diagnostic criteria for ASD. By first reviewing how sensory processing has been studied to date, we direct our focus to electrophysiological and behavioral techniques that can be used to study sensory phenotypes consistently across species. Using auditory sensory phenotypes as a template, we seek to improve the accessibility of translational methods by providing a framework for collecting cohesive data in both rodents and humans. Specifically, evoked-potentials, acoustic startle paradigms, and psychophysical detection/discrimination paradigms can be created and implemented in a coordinated and systematic fashion across species. Through careful protocol design and collaboration, sensory processing phenotypes can be harnessed to bridge the gap that exists between preclinical animal studies and human testing, so that mutually held questions in autism research can be answered. LAY SUMMARY: It has always been difficult to relate results from animal research to humans. We try to close this gap by studying changes in sensory processing using careful protocol design and collaboration between clinicians and researchers. Sensory pathways are comparable between animals and humans, and are affected in the same way as the rest of the brain in ASD. Using changes in hearing as a template, we point the field in an innovative direction by providing a framework for collecting cohesive data in rodents and humans. En ligne : http://dx.doi.org/10.1002/aur.2533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Closing the species gap: Translational approaches to studying sensory processing differences relevant for autism spectrum disorder [Texte imprimé et/ou numérique] / Kaela E. SCOTT, Auteur ; S. E. SCHULZ, Auteur ; D. MOEHRLE, Auteur ; Brian L. ALLMAN, Auteur ; Janis ORAM CARDY, Auteur ; R. A. STEVENSON, Auteur ; S. SCHMID, Auteur . - p.1322-1331. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1322-1331 Mots-clés : Animals  Autism Spectrum Disorder  Cognition  Evoked Potentials  Humans  Mice  Perception  Sensation  auditory processing  experimental design  framework  sensory phenotypes  species translation Index. décimale : PER Périodiques Résumé : The study of sensory phenotypes has great potential for increasing research translation between species, a necessity to decipher the neural mechanisms that contribute to higher-order differences in neurological conditions such as autism spectrum disorder (ASD). Over the past decade, despite separate advances in our understanding of the structural and functional differences within the brain of autistic and non-autistic individuals and in rodent models for ASD, researchers have had difficulty translating the findings in murine species to humans, mostly due to incompatibility in experimental methodologies used to screen for ASD phenotypes. Focusing on sensory phenotypes offers an avenue to close the species gap because sensory pathways are highly conserved across species and are affected by the same risk-factors as the higher-order brain areas mostly responsible for the diagnostic criteria for ASD. By first reviewing how sensory processing has been studied to date, we direct our focus to electrophysiological and behavioral techniques that can be used to study sensory phenotypes consistently across species. Using auditory sensory phenotypes as a template, we seek to improve the accessibility of translational methods by providing a framework for collecting cohesive data in both rodents and humans. Specifically, evoked-potentials, acoustic startle paradigms, and psychophysical detection/discrimination paradigms can be created and implemented in a coordinated and systematic fashion across species. Through careful protocol design and collaboration, sensory processing phenotypes can be harnessed to bridge the gap that exists between preclinical animal studies and human testing, so that mutually held questions in autism research can be answered. LAY SUMMARY: It has always been difficult to relate results from animal research to humans. We try to close this gap by studying changes in sensory processing using careful protocol design and collaboration between clinicians and researchers. Sensory pathways are comparable between animals and humans, and are affected in the same way as the rest of the brain in ASD. Using changes in hearing as a template, we point the field in an innovative direction by providing a framework for collecting cohesive data in rodents and humans. En ligne : http://dx.doi.org/10.1002/aur.2533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Convergent Validity of Behavioural and Subjective Sensitivity in Relation to Autistic Traits / S. E. SCHULZ in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.758-770 Titre : Convergent Validity of Behavioural and Subjective Sensitivity in Relation to Autistic Traits Type de document : Texte imprimé et/ou numérique Auteurs : S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : p.758-770 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Humans  Sensation  Surveys and Questionnaires  Visual Perception  Autism spectrum disorder  Autistic traits  Sensory processing  Sensory reactivity  Sensory sensitivity Index. décimale : PER Périodiques Résumé : Sensory issues are highly prevalent in autism and previous findings support a relationship between questionnaires of sensitivity and autistic symptoms and traits, whereas studies that examine this relationship through behavioural assessments of sensitivity are less consistent. The current study explores these differences and suggests that behavioural thresholds for sensitivity and subjective sensitivity are distinct constructs. One hundred and eighteen adults completed a visual and auditory detection task and questionnaires on sensory processing and autistic traits. Visual thresholds and subjective visual sensitivity were not correlated, but both were related to autistic traits. Auditory thresholds and subjective auditory sensitivity were also unrelated. Overall, sensitivity is highly associated with autistic traits, however, behavioural and questionnaire assessments lack convergent validity and therefore, likely assess distinct constructs. En ligne : http://dx.doi.org/10.1007/s10803-021-04974-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Convergent Validity of Behavioural and Subjective Sensitivity in Relation to Autistic Traits [Texte imprimé et/ou numérique] / S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur . - p.758-770. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.758-770 Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Humans  Sensation  Surveys and Questionnaires  Visual Perception  Autism spectrum disorder  Autistic traits  Sensory processing  Sensory reactivity  Sensory sensitivity Index. décimale : PER Périodiques Résumé : Sensory issues are highly prevalent in autism and previous findings support a relationship between questionnaires of sensitivity and autistic symptoms and traits, whereas studies that examine this relationship through behavioural assessments of sensitivity are less consistent. The current study explores these differences and suggests that behavioural thresholds for sensitivity and subjective sensitivity are distinct constructs. One hundred and eighteen adults completed a visual and auditory detection task and questionnaires on sensory processing and autistic traits. Visual thresholds and subjective visual sensitivity were not correlated, but both were related to autistic traits. Auditory thresholds and subjective auditory sensitivity were also unrelated. Overall, sensitivity is highly associated with autistic traits, however, behavioural and questionnaire assessments lack convergent validity and therefore, likely assess distinct constructs. En ligne : http://dx.doi.org/10.1007/s10803-021-04974-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Differentiating between sensory sensitivity and sensory reactivity in relation to restricted interests and repetitive behaviours / S. E. SCHULZ in Autism, 24-1 (January 2020)  

Public ISBD [article]  inAutism > 24-1 (January 2020) . - p.121-134 Titre : Differentiating between sensory sensitivity and sensory reactivity in relation to restricted interests and repetitive behaviours Type de document : Texte imprimé et/ou numérique Auteurs : S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : p.121-134 Langues : Anglais (eng) Mots-clés : adults  autism spectrum disorders  behavioural measurement  reactivity  repetitive behaviours and interests  sensitivity  sensory impairments Index. décimale : PER Périodiques Résumé : Recent studies have suggested that individuals who exhibit heightened sensitivity also exhibit higher rates and severity of restricted interests and repetitive behaviours. This line of research has been conducted almost exclusively through caregiver reports of sensitivity. Here, a more rigorous psychophysics paradigm was applied to assess sensory sensitivity and relate hypersensitivity to restricted interests and repetitive behaviours. In addition, commonly used questionnaire measures of sensory sensitivity were collected to determine if self-reported measures accurately reflect behavioural measures of sensory sensitivity. In all, 90 typically developing participants completed a visual detection task, a questionnaire measure of sensory processing and a measure of restricted interests and repetitive behaviours. Visual sensitivity, measured both behaviourally and with questionnaires, is positively related to restricted interests and repetitive behaviours. Surprisingly, visual sensitivity as measured behaviourally and through self-report are unrelated. Furthermore, a regression analysis suggests that while restricted interests and repetitive behaviours can be predicted based on both behavioural and self-reported sensitivity, these two predictors account for different portions of the variance in restricted interests and repetitive behaviours. Thus, while these results provide evidence supporting the contribution of sensory sensitivity to restricted interests and repetitive behaviours, these results also indicate that behavioural and questionnaire measures of sensory sensitivity are measuring two distinct constructs. We hypothesize that behavioural measures are measuring sensory sensitivity, while questionnaires measures are in fact measuring sensory reactivity. En ligne : http://dx.doi.org/10.1177/1362361319850402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] Differentiating between sensory sensitivity and sensory reactivity in relation to restricted interests and repetitive behaviours [Texte imprimé et/ou numérique] / S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur . - p.121-134. Langues : Anglais (eng) in Autism > 24-1 (January 2020) . - p.121-134 Mots-clés : adults  autism spectrum disorders  behavioural measurement  reactivity  repetitive behaviours and interests  sensitivity  sensory impairments Index. décimale : PER Périodiques Résumé : Recent studies have suggested that individuals who exhibit heightened sensitivity also exhibit higher rates and severity of restricted interests and repetitive behaviours. This line of research has been conducted almost exclusively through caregiver reports of sensitivity. Here, a more rigorous psychophysics paradigm was applied to assess sensory sensitivity and relate hypersensitivity to restricted interests and repetitive behaviours. In addition, commonly used questionnaire measures of sensory sensitivity were collected to determine if self-reported measures accurately reflect behavioural measures of sensory sensitivity. In all, 90 typically developing participants completed a visual detection task, a questionnaire measure of sensory processing and a measure of restricted interests and repetitive behaviours. Visual sensitivity, measured both behaviourally and with questionnaires, is positively related to restricted interests and repetitive behaviours. Surprisingly, visual sensitivity as measured behaviourally and through self-report are unrelated. Furthermore, a regression analysis suggests that while restricted interests and repetitive behaviours can be predicted based on both behavioural and self-reported sensitivity, these two predictors account for different portions of the variance in restricted interests and repetitive behaviours. Thus, while these results provide evidence supporting the contribution of sensory sensitivity to restricted interests and repetitive behaviours, these results also indicate that behavioural and questionnaire measures of sensory sensitivity are measuring two distinct constructs. We hypothesize that behavioural measures are measuring sensory sensitivity, while questionnaires measures are in fact measuring sensory reactivity. En ligne : http://dx.doi.org/10.1177/1362361319850402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder / N. J. BRIERLEY in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3391-3400 Titre : Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : N. J. BRIERLEY, Auteur ; C. G. MCDONNELL, Auteur ; K. M. A. PARKS, Auteur ; S. E. SCHULZ, Auteur ; T. C. DALAL, Auteur ; E. KELLEY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; J. CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : p.3391-3400 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/diagnosis/epidemiology  Autism Spectrum Disorder/diagnosis  Child  Female  Humans  Stereotyped Behavior  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Factor analysis  Restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Restricted interests and repetitive behaviors (RRBs) are core symptoms of autism spectrum disorder (ASD), and commonly occur in attention-deficit/hyperactivity disorder (ADHD). Little is known about how RRBs manifest in ADHD. We quantified and compared factor structures of RRBs in children with ASD (n?=?634) or ADHD (n?=?448), and related factors to sex and IQ. A four-factor solution emerged, including Stereotypy, Self-Injury, Compulsions, and Ritualistic/Sameness. Factor structures were equivalent across diagnoses, though symptoms were more severe in ASD. IQ negatively correlated with Stereotypy, Self-Injury, and Compulsions in ASD, and negatively correlated with Compulsions and Ritualistic/Sameness behaviors in ADHD. In ASD only, females exhibited higher Self-Injury. Thus, patterns of RRBs are preserved across ASD and ADHD, but severity and relationship with IQ differed. En ligne : http://dx.doi.org/10.1007/s10803-020-04800-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder [Texte imprimé et/ou numérique] / N. J. BRIERLEY, Auteur ; C. G. MCDONNELL, Auteur ; K. M. A. PARKS, Auteur ; S. E. SCHULZ, Auteur ; T. C. DALAL, Auteur ; E. KELLEY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; J. CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; X. LIU, Auteur ; R. A. STEVENSON, Auteur . - p.3391-3400. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3391-3400 Mots-clés : Attention Deficit Disorder with Hyperactivity/diagnosis/epidemiology  Autism Spectrum Disorder/diagnosis  Child  Female  Humans  Stereotyped Behavior  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Factor analysis  Restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Restricted interests and repetitive behaviors (RRBs) are core symptoms of autism spectrum disorder (ASD), and commonly occur in attention-deficit/hyperactivity disorder (ADHD). Little is known about how RRBs manifest in ADHD. We quantified and compared factor structures of RRBs in children with ASD (n?=?634) or ADHD (n?=?448), and related factors to sex and IQ. A four-factor solution emerged, including Stereotypy, Self-Injury, Compulsions, and Ritualistic/Sameness. Factor structures were equivalent across diagnoses, though symptoms were more severe in ASD. IQ negatively correlated with Stereotypy, Self-Injury, and Compulsions in ASD, and negatively correlated with Compulsions and Ritualistic/Sameness behaviors in ADHD. In ASD only, females exhibited higher Self-Injury. Thus, patterns of RRBs are preserved across ASD and ADHD, but severity and relationship with IQ differed. En ligne : http://dx.doi.org/10.1007/s10803-020-04800-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Sensory hypersensitivity predicts repetitive behaviours in autistic and typically-developing children / S. E. SCHULZ in Autism, 23-4 (May 2019)  

Public ISBD [article]  inAutism > 23-4 (May 2019) . - p.1028-1041 Titre : Sensory hypersensitivity predicts repetitive behaviours in autistic and typically-developing children Type de document : Texte imprimé et/ou numérique Auteurs : S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur Article en page(s) : p.1028-1041 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  repetitive behaviours  restricted interests  sensory hypersensitivity  sensory processing Index. décimale : PER Périodiques Résumé : The objective of this study was to examine the relationship between sensory hypersensitivity and restricted interests and repetitive behaviours associated with autism spectrum disorder and their typically-developing peers. Furthermore, the aims included the examination of the relationship across sensory modalities and various types of restricted interests and repetitive behaviours. Data were collected from the parents of 114 children: 49 of whom were diagnosed with autism spectrum disorder and 65 typically-developing children. Parents completed the Sensory Profile 2 - Child Version and the Repetitive Behaviours Questionnaire, Second Edition. The results suggested that sensory hypersensitivity is strongly related to the core autism spectrum disorder symptom of repetitive behaviours. This relationship was not specific to autism spectrum disorder; repetitive behaviours significantly increased with sensory hypersensitivity in typically-developing individuals as well. This effect was consistent across all modalities in both autism spectrum disorder and typically developing groups; group differences were observed in the oral and tactile modalities. Furthermore, sensory hypersensitivity was significantly predictive of repetitive behaviours in all participants, autism spectrum disorder and typically-developing, and importantly, autism spectrum disorder diagnosis did not add any predictive influence above and beyond sensory hypersensitivity. Finally, sensory hypersensitivity was significantly predictive of all subdomains of repetitive behaviours, including repetitive motor movements, rigidity and adherence to routine, preoccupation with restricted patterns of interest and unusual sensory interests, and diagnosis added no predictive ability beyond sensory hypersensitivity. En ligne : http://dx.doi.org/10.1177/1362361318774559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Sensory hypersensitivity predicts repetitive behaviours in autistic and typically-developing children [Texte imprimé et/ou numérique] / S. E. SCHULZ, Auteur ; R. A. STEVENSON, Auteur . - p.1028-1041. Langues : Anglais (eng) in Autism > 23-4 (May 2019) . - p.1028-1041 Mots-clés : autism spectrum disorder  repetitive behaviours  restricted interests  sensory hypersensitivity  sensory processing Index. décimale : PER Périodiques Résumé : The objective of this study was to examine the relationship between sensory hypersensitivity and restricted interests and repetitive behaviours associated with autism spectrum disorder and their typically-developing peers. Furthermore, the aims included the examination of the relationship across sensory modalities and various types of restricted interests and repetitive behaviours. Data were collected from the parents of 114 children: 49 of whom were diagnosed with autism spectrum disorder and 65 typically-developing children. Parents completed the Sensory Profile 2 - Child Version and the Repetitive Behaviours Questionnaire, Second Edition. The results suggested that sensory hypersensitivity is strongly related to the core autism spectrum disorder symptom of repetitive behaviours. This relationship was not specific to autism spectrum disorder; repetitive behaviours significantly increased with sensory hypersensitivity in typically-developing individuals as well. This effect was consistent across all modalities in both autism spectrum disorder and typically developing groups; group differences were observed in the oral and tactile modalities. Furthermore, sensory hypersensitivity was significantly predictive of repetitive behaviours in all participants, autism spectrum disorder and typically-developing, and importantly, autism spectrum disorder diagnosis did not add any predictive influence above and beyond sensory hypersensitivity. Finally, sensory hypersensitivity was significantly predictive of all subdomains of repetitive behaviours, including repetitive motor movements, rigidity and adherence to routine, preoccupation with restricted patterns of interest and unusual sensory interests, and diagnosis added no predictive ability beyond sensory hypersensitivity. En ligne : http://dx.doi.org/10.1177/1362361318774559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

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