Characterising the Early Presentation of Motor Difficulties in Autistic Children / Jess E. REYNOLDS in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4739-4749 Titre : Characterising the Early Presentation of Motor Difficulties in Autistic Children Type de document : texte imprimé Auteurs : Jess E. REYNOLDS, Auteur ; Andrew J.O. WHITEHOUSE, Auteur ; Gail A. ALVARES, Auteur ; Hannah WADDINGTON, Auteur ; Ella MACASKILL, Auteur ; Melissa K. LICARI, Auteur Article en page(s) : p.4739-4749 Langues : Anglais (eng) Mots-clés : Australia  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Child  Child, Preschool  Female  Humans  Learning  Longitudinal Studies  Male  Autism spectrum disorders  Motor (control, system)  Motor development  Motor disorders  Motor skills  Movement Index. décimale : PER Périodiques Résumé : This study aimed to explore the rates of motor difficulties in children from the Australian Autism Biobank, and how early motor concerns impacted on children functionally. Children with autism aged 2-7 years, including 441 with a Vineland Adaptive Behavior Scale (VABS-II) motor subscale and 385 with a Mullen Scales of Early Learning (MSEL) fine motor subscale were included (n total=514; 80% male). Approximately 60% of children on the MSEL and ~ 25% on the VABS-II had clinically significant motor impairments. More children with delayed sitting and walking motor milestones had early childhood parent reported motor difficulties (p < 0.001). Early motor delays or concerns may assist identifying individuals who will likely benefit from early ongoing developmental monitoring and early support. En ligne : http://dx.doi.org/10.1007/s10803-021-05333-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Characterising the Early Presentation of Motor Difficulties in Autistic Children [texte imprimé] / Jess E. REYNOLDS, Auteur ; Andrew J.O. WHITEHOUSE, Auteur ; Gail A. ALVARES, Auteur ; Hannah WADDINGTON, Auteur ; Ella MACASKILL, Auteur ; Melissa K. LICARI, Auteur . - p.4739-4749. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4739-4749 Mots-clés : Australia  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Child  Child, Preschool  Female  Humans  Learning  Longitudinal Studies  Male  Autism spectrum disorders  Motor (control, system)  Motor development  Motor disorders  Motor skills  Movement Index. décimale : PER Périodiques Résumé : This study aimed to explore the rates of motor difficulties in children from the Australian Autism Biobank, and how early motor concerns impacted on children functionally. Children with autism aged 2-7 years, including 441 with a Vineland Adaptive Behavior Scale (VABS-II) motor subscale and 385 with a Mullen Scales of Early Learning (MSEL) fine motor subscale were included (n total=514; 80% male). Approximately 60% of children on the MSEL and ~ 25% on the VABS-II had clinically significant motor impairments. More children with delayed sitting and walking motor milestones had early childhood parent reported motor difficulties (p < 0.001). Early motor delays or concerns may assist identifying individuals who will likely benefit from early ongoing developmental monitoring and early support. En ligne : http://dx.doi.org/10.1007/s10803-021-05333-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Investigating associations between birth order and autism diagnostic phenotypes / Gail A. ALVARES in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.961-970 Titre : Investigating associations between birth order and autism diagnostic phenotypes Type de document : texte imprimé Auteurs : Gail A. ALVARES, Auteur ; Melissa K. LICARI, Auteur ; Paul G. STEVENSON, Auteur ; Keely BEBBINGTON, Auteur ; Matthew N. COOPER, Auteur ; Emma J. GLASSON, Auteur ; Diana Weiting TAN, Auteur ; Mirko ULJAREVIĆ, Auteur ; Kandice J. VARCIN, Auteur ; John WRAY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur Article en page(s) : p.961-970 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Birth Order  Child, Preschool  Female  Humans  Male  Phenotype  Prospective Studies  Autism spectrum disorder  diagnosis  first birth  intellectual disability Index. décimale : PER Périodiques Résumé : BACKGROUND: Birth order effects have been linked to variability in intelligence, educational attainment and sexual orientation. First- and later-born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order. The present study investigated the potential association between birth order and ASD diagnostic phenotypes in a large and representative population sample. METHODS: Data were obtained from an ongoing prospective diagnostic registry, collected between 1999 and 2017, including children (1-18 years of age, n = 5,404) diagnosed with ASD in the state of Western Australia. Children with ASD were ranked relative to sibling's birth to establish birth order within families at time of ASD diagnosis. Information reported to the registry by health professionals at the time of diagnostic evaluation included demographic and family characteristics, functional abilities and intellectual capacity. RESULTS: Adaptive functioning and intelligence scores decreased with increasing birth order, with later-born children more likely to have an intellectual disability. Compared to first-born children with siblings, first-born children without siblings at the time of diagnosis also exhibited decreased cognitive functioning. CONCLUSIONS: These findings demonstrate for the first time an association between increasing birth order and variability in ASD clinical phenotypes at diagnosis, with potential evidence of reproductive curtailment in children without siblings. Taken together, these findings have significant implications for advancing understanding about the potential mechanisms that contribute to heterogeneity in ASD clinical presentations as a function of birth order and family size. En ligne : http://dx.doi.org/10.1111/jcpp.13349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Investigating associations between birth order and autism diagnostic phenotypes [texte imprimé] / Gail A. ALVARES, Auteur ; Melissa K. LICARI, Auteur ; Paul G. STEVENSON, Auteur ; Keely BEBBINGTON, Auteur ; Matthew N. COOPER, Auteur ; Emma J. GLASSON, Auteur ; Diana Weiting TAN, Auteur ; Mirko ULJAREVIĆ, Auteur ; Kandice J. VARCIN, Auteur ; John WRAY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur . - p.961-970. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.961-970 Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Birth Order  Child, Preschool  Female  Humans  Male  Phenotype  Prospective Studies  Autism spectrum disorder  diagnosis  first birth  intellectual disability Index. décimale : PER Périodiques Résumé : BACKGROUND: Birth order effects have been linked to variability in intelligence, educational attainment and sexual orientation. First- and later-born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order. The present study investigated the potential association between birth order and ASD diagnostic phenotypes in a large and representative population sample. METHODS: Data were obtained from an ongoing prospective diagnostic registry, collected between 1999 and 2017, including children (1-18 years of age, n = 5,404) diagnosed with ASD in the state of Western Australia. Children with ASD were ranked relative to sibling's birth to establish birth order within families at time of ASD diagnosis. Information reported to the registry by health professionals at the time of diagnostic evaluation included demographic and family characteristics, functional abilities and intellectual capacity. RESULTS: Adaptive functioning and intelligence scores decreased with increasing birth order, with later-born children more likely to have an intellectual disability. Compared to first-born children with siblings, first-born children without siblings at the time of diagnosis also exhibited decreased cognitive functioning. CONCLUSIONS: These findings demonstrate for the first time an association between increasing birth order and variability in ASD clinical phenotypes at diagnosis, with potential evidence of reproductive curtailment in children without siblings. Taken together, these findings have significant implications for advancing understanding about the potential mechanisms that contribute to heterogeneity in ASD clinical presentations as a function of birth order and family size. En ligne : http://dx.doi.org/10.1111/jcpp.13349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Motor impairment should be a "Specifier" for autism spectrum disorder / Melissa K. LICARI in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2010-2011 Titre : Motor impairment should be a "Specifier" for autism spectrum disorder Type de document : texte imprimé Auteurs : Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Jess E. REYNOLDS, Auteur ; Mirko ULJAVERIC, Auteur Article en page(s) : p.2010-2011 Langues : Anglais (eng) Mots-clés : Humans  Autism Spectrum Disorder  Motor Disorders  Motor Skills Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Motor impairment should be a "Specifier" for autism spectrum disorder [texte imprimé] / Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Jess E. REYNOLDS, Auteur ; Mirko ULJAVERIC, Auteur . - p.2010-2011. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2010-2011 Mots-clés : Humans  Autism Spectrum Disorder  Motor Disorders  Motor Skills Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Prevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort / Melissa K. LICARI in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.298-306 Titre : Prevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort Type de document : texte imprimé Auteurs : Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Kandice J. VARCIN, Auteur ; Kiah EVANS, Auteur ; Dominique CLEARY, Auteur ; Siobhan L. REID, Auteur ; Emma J. GLASSON, Auteur ; Keely BEBBINGTON, Auteur ; Jess E. REYNOLDS, Auteur ; John WRAY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur Article en page(s) : p.298-306 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental disabilities  motor disorders  motor skills  movement Index. décimale : PER Périodiques Résumé : Motor impairment is not currently included in the diagnostic criteria or evaluation of autism. This reflects the lack of large-scale studies demonstrating its prominence to advocate for change. We examined the prevalence of motor difficulties at the time of diagnosis in a large sample of children with autism utilizing standardized assessment, and the relationship between motor difficulties, core autism symptomology, and other prominent clinical features. Vineland Adaptive Behavior Scales were administered to children from the Western Australian Register for Autism Spectrum Disorders aged En ligne : http://dx.doi.org/10.1002/aur.2230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Prevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort [texte imprimé] / Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Kandice J. VARCIN, Auteur ; Kiah EVANS, Auteur ; Dominique CLEARY, Auteur ; Siobhan L. REID, Auteur ; Emma J. GLASSON, Auteur ; Keely BEBBINGTON, Auteur ; Jess E. REYNOLDS, Auteur ; John WRAY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur . - p.298-306. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.298-306 Mots-clés : autism spectrum disorder  developmental disabilities  motor disorders  motor skills  movement Index. décimale : PER Périodiques Résumé : Motor impairment is not currently included in the diagnostic criteria or evaluation of autism. This reflects the lack of large-scale studies demonstrating its prominence to advocate for change. We examined the prevalence of motor difficulties at the time of diagnosis in a large sample of children with autism utilizing standardized assessment, and the relationship between motor difficulties, core autism symptomology, and other prominent clinical features. Vineland Adaptive Behavior Scales were administered to children from the Western Australian Register for Autism Spectrum Disorders aged En ligne : http://dx.doi.org/10.1002/aur.2230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

The course and prognostic capability of motor difficulties in infants showing early signs of autism / Melissa K. LICARI in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1759-1768 Titre : The course and prognostic capability of motor difficulties in infants showing early signs of autism Type de document : texte imprimé Auteurs : Melissa K. LICARI, Auteur ; Kandice J. VARCIN, Auteur ; Kristelle HUDRY, Auteur ; Hayley C. LEONARD, Auteur ; Gail A. ALVARES, Auteur ; Sarah PILLAR, Auteur ; Paul G. STEVENSON, Auteur ; Matthew N. COOPER, Auteur ; Andrew J.O. WHITEHOUSE, Auteur Article en page(s) : p.1759-1768 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Humans  Infant  Motor Skills  Prognosis  Prospective Studies  early identification  infancy  motor skills Index. décimale : PER Périodiques Résumé : Delays within the motor domain are often overlooked as an early surveillance marker for autism. The present study evaluated motor difficulties and its potential as an early predictive marker for later autism likelihood in a cohort of infants (N = 96) showing early behavioral signs of autism aged 9-14 months. The motor domain was evaluated using the motor subscales of the Mullen Scales of Early Learning at baseline, and at a 6-month follow-up. The Autism Diagnostic Observation Schedule - Toddler Module (ADOS-T) was completed at follow-up as a measure of autism likelihood. Motor difficulties were common at baseline, with 63/96 (65.6%) infants scoring very low or below average in the gross motor domain and 29/96 (30.2%) in the fine motor domain. At follow-up, gross motor difficulties had resolved for many, with 23/63 (36.5%) infants maintaining these difficulties. Fine motor difficulties resolved in fewer infants, with 20/29 (69.0%) continuing to present with fine motor delays at follow-up. Adjusted linear regression models suggested that fine motor scores at baseline (β = -0.12, SE = 0.04) and follow-up (β = -0.17, SE = 0.05) were associated with higher ADOS-T scores; with difficulties across both timepoints (β = 5.60, SE = 1.35) the strongest (largest in magnitude) association with ADOS-T scores of the predictors examined. Motor difficulties are prominent in children displaying emerging signs of autism, with persistent fine motor difficulties predictive of the developing autism phenotype. The findings indicate the potential clinical value of including evaluation of motor skills within early autism surveillance measures. LAY SUMMARY: This prospective study evaluated motor development over a 6-month period in infants showing early behavioral signs of autism. Atypical motor development was a common feature of infants showing early signs of autism and persistent fine motor difficulties were predictive of the emerging autism phenotype. En ligne : http://dx.doi.org/10.1002/aur.2545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] The course and prognostic capability of motor difficulties in infants showing early signs of autism [texte imprimé] / Melissa K. LICARI, Auteur ; Kandice J. VARCIN, Auteur ; Kristelle HUDRY, Auteur ; Hayley C. LEONARD, Auteur ; Gail A. ALVARES, Auteur ; Sarah PILLAR, Auteur ; Paul G. STEVENSON, Auteur ; Matthew N. COOPER, Auteur ; Andrew J.O. WHITEHOUSE, Auteur . - p.1759-1768. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1759-1768 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Humans  Infant  Motor Skills  Prognosis  Prospective Studies  early identification  infancy  motor skills Index. décimale : PER Périodiques Résumé : Delays within the motor domain are often overlooked as an early surveillance marker for autism. The present study evaluated motor difficulties and its potential as an early predictive marker for later autism likelihood in a cohort of infants (N = 96) showing early behavioral signs of autism aged 9-14 months. The motor domain was evaluated using the motor subscales of the Mullen Scales of Early Learning at baseline, and at a 6-month follow-up. The Autism Diagnostic Observation Schedule - Toddler Module (ADOS-T) was completed at follow-up as a measure of autism likelihood. Motor difficulties were common at baseline, with 63/96 (65.6%) infants scoring very low or below average in the gross motor domain and 29/96 (30.2%) in the fine motor domain. At follow-up, gross motor difficulties had resolved for many, with 23/63 (36.5%) infants maintaining these difficulties. Fine motor difficulties resolved in fewer infants, with 20/29 (69.0%) continuing to present with fine motor delays at follow-up. Adjusted linear regression models suggested that fine motor scores at baseline (β = -0.12, SE = 0.04) and follow-up (β = -0.17, SE = 0.05) were associated with higher ADOS-T scores; with difficulties across both timepoints (β = 5.60, SE = 1.35) the strongest (largest in magnitude) association with ADOS-T scores of the predictors examined. Motor difficulties are prominent in children displaying emerging signs of autism, with persistent fine motor difficulties predictive of the developing autism phenotype. The findings indicate the potential clinical value of including evaluation of motor skills within early autism surveillance measures. LAY SUMMARY: This prospective study evaluated motor development over a 6-month period in infants showing early behavioral signs of autism. Atypical motor development was a common feature of infants showing early signs of autism and persistent fine motor difficulties were predictive of the emerging autism phenotype. En ligne : http://dx.doi.org/10.1002/aur.2545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

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