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Auteur Irva HERTZ-PICCIOTTO |
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Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort / Dina TERLOYEVA in Molecular Autism, 11 (2020)
[article]
Titre : Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort Type de document : Texte imprimé et/ou numérique Auteurs : Dina TERLOYEVA, Auteur ; Alexander J. FREY, Auteur ; Bo Y. PARK, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Leny MATHEW, Auteur ; Anna BOSTWICK, Auteur ; Erika L. VARNER, Auteur ; Brian K. LEE, Auteur ; Lisa A. CROEN, Auteur ; Margaret D. FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur ; Nathaniel W. SNYDER, Auteur Langues : Anglais (eng) Mots-clés : Androgen Autism-related traits Meconium Prenatal exposure Sex difference Sibling Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has been examined by measurement of steroids in amniotic fluid, cord blood, saliva, and blood with mixed results. METHODS: To provide an orthogonal measure of fetal exposure, this study used meconium, the first stool of a newborn, to measure prenatal androgen exposure from infants in the Early Autism Risk Longitudinal Investigation (EARLI). EARLI is a familial-enriched risk cohort that enrolled pregnant mothers who already had a child with an ASD diagnosis. In the younger child, we investigated the association between meconium unconjugated (u) and total (t) concentrations of major androgens testosterone (T), dehydroepiandrosterone (DHEA), and androstenedione (A4), and ASD-related traits at 12 and 36 months of age. Traits were measured at 12 months with Autism Observation Scale for Infants (AOSI) and at 36 months with total score on the Social Responsiveness Scale (SRS). One hundred and seventy children had meconium and AOSI, 140 had meconium and SRS, and 137 had meconium and both AOSI and SRS. RESULTS: Separate robust linear regressions between each of the log-transformed androgens and log-transformed SRS scores revealed three-way interaction between sex of the child, sex of the proband, and testosterone concentration. In the adjusted analyses, t-T, u-A4, and u-DHEA (P???0.01) were positively associated with AOSI scores, while u-T (P?=?0.004) and u-DHEA (P?=?0.007) were positively associated with SRS total score among females with female probands (n?=?10). Additionally, higher concentrations of u-T (P?=?0.01) and t-T (P?=?0.01) predicted higher SRS total score in males with male probands (n?=?63). Limitations Since we explored three-way interactions, this resulted in a limited sample size for some analyses. This study was from an enriched-risk cohort which may limit generalizability, and this study used ASD-assessment scales as outcomes instead of diagnostic categories. Additionally, the novel use of meconium in this study limits the ability to compare the results in this cohort to others due to the paucity of research on meconium. CONCLUSIONS: This study supports the utility of meconium for studies of endogenous fetal metabolism and suggests the sex of older siblings with autism should be considered as a biological variable in relevant studies. En ligne : http://dx.doi.org/10.1186/s13229-020-00395-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Molecular Autism > 11 (2020)[article] Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort [Texte imprimé et/ou numérique] / Dina TERLOYEVA, Auteur ; Alexander J. FREY, Auteur ; Bo Y. PARK, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Leny MATHEW, Auteur ; Anna BOSTWICK, Auteur ; Erika L. VARNER, Auteur ; Brian K. LEE, Auteur ; Lisa A. CROEN, Auteur ; Margaret D. FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur ; Nathaniel W. SNYDER, Auteur.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020)
Mots-clés : Androgen Autism-related traits Meconium Prenatal exposure Sex difference Sibling Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has been examined by measurement of steroids in amniotic fluid, cord blood, saliva, and blood with mixed results. METHODS: To provide an orthogonal measure of fetal exposure, this study used meconium, the first stool of a newborn, to measure prenatal androgen exposure from infants in the Early Autism Risk Longitudinal Investigation (EARLI). EARLI is a familial-enriched risk cohort that enrolled pregnant mothers who already had a child with an ASD diagnosis. In the younger child, we investigated the association between meconium unconjugated (u) and total (t) concentrations of major androgens testosterone (T), dehydroepiandrosterone (DHEA), and androstenedione (A4), and ASD-related traits at 12 and 36 months of age. Traits were measured at 12 months with Autism Observation Scale for Infants (AOSI) and at 36 months with total score on the Social Responsiveness Scale (SRS). One hundred and seventy children had meconium and AOSI, 140 had meconium and SRS, and 137 had meconium and both AOSI and SRS. RESULTS: Separate robust linear regressions between each of the log-transformed androgens and log-transformed SRS scores revealed three-way interaction between sex of the child, sex of the proband, and testosterone concentration. In the adjusted analyses, t-T, u-A4, and u-DHEA (P???0.01) were positively associated with AOSI scores, while u-T (P?=?0.004) and u-DHEA (P?=?0.007) were positively associated with SRS total score among females with female probands (n?=?10). Additionally, higher concentrations of u-T (P?=?0.01) and t-T (P?=?0.01) predicted higher SRS total score in males with male probands (n?=?63). Limitations Since we explored three-way interactions, this resulted in a limited sample size for some analyses. This study was from an enriched-risk cohort which may limit generalizability, and this study used ASD-assessment scales as outcomes instead of diagnostic categories. Additionally, the novel use of meconium in this study limits the ability to compare the results in this cohort to others due to the paucity of research on meconium. CONCLUSIONS: This study supports the utility of meconium for studies of endogenous fetal metabolism and suggests the sex of older siblings with autism should be considered as a biological variable in relevant studies. En ligne : http://dx.doi.org/10.1186/s13229-020-00395-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 MECP2 promoter methylation and X chromosome inactivation in autism / Raman P. NAGARAJAN in Autism Research, 1-3 (June 2008)
[article]
Titre : MECP2 promoter methylation and X chromosome inactivation in autism Type de document : Texte imprimé et/ou numérique Auteurs : Raman P. NAGARAJAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Wendy P. ROBINSON, Auteur ; Ruby JIANG, Auteur ; Susan E. SWANBERG, Auteur ; Dag H. YASUI, Auteur ; Michelle MARTIN, Auteur ; Katherine A. PATZEL, Auteur ; Janine M. LASALLE, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; David J. HANSEN, Auteur Année de publication : 2008 Article en page(s) : p.169-178 Langues : Anglais (eng) Mots-clés : epigenetics X-chromosome-inactivation MECP2 postmortem-brain Index. décimale : PER Périodiques Résumé : Epigenetic mechanisms have been proposed to play a role in the etiology of autism. This hypothesis is supported by the discovery of increased MECP2 promoter methylation associated with decreased MeCP2 protein expression in autism male brain. To further understand the influence of female X chromosome inactivation (XCI) and neighboring methylation patterns on aberrant MECP2 promoter methylation in autism, multiple methylation analyses were performed on brain and blood samples from individuals with autism. Bisulfite sequencing analyses of a region 0.6 kb upstream of MECP2 in brain DNA samples revealed an abrupt transition from a highly methylated region in both sexes to a region unmethylated in males and subject to XCI in females. Chromatin immunoprecipitation analysis demonstrated that the CCCTC-binding factor (CTCF) is bound to this transition region in neuronal cells, consistent with a chromatin boundary at the methylation transition. Male autism brain DNA samples displayed a slight increase in methylation in this transition region, suggesting a possible aberrant spreading of methylation into the MECP2 promoter in autism males across this boundary element. In addition, autistic female brain DNA samples showed evidence for aberrant MECP2 promoter methylation as an increase in the number of bisulfite sequenced clones with undefined XCI status for MECP2 but not androgen receptor (AR). To further investigate the specificity of MECP2 methylation alterations in autism, blood DNA samples from females and mothers of males with autism were also examined for XCI skewing at AR, but no significant increase in XCI skewing was observed compared to controls. These results suggest that the aberrant MECP2 methylation in autism brain DNA samples is due to locus-specific rather than global X chromosome methylation changes. En ligne : http://dx.doi.org/10.1002/aur.24 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=931
in Autism Research > 1-3 (June 2008) . - p.169-178[article] MECP2 promoter methylation and X chromosome inactivation in autism [Texte imprimé et/ou numérique] / Raman P. NAGARAJAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Wendy P. ROBINSON, Auteur ; Ruby JIANG, Auteur ; Susan E. SWANBERG, Auteur ; Dag H. YASUI, Auteur ; Michelle MARTIN, Auteur ; Katherine A. PATZEL, Auteur ; Janine M. LASALLE, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; David J. HANSEN, Auteur . - 2008 . - p.169-178.
Langues : Anglais (eng)
in Autism Research > 1-3 (June 2008) . - p.169-178
Mots-clés : epigenetics X-chromosome-inactivation MECP2 postmortem-brain Index. décimale : PER Périodiques Résumé : Epigenetic mechanisms have been proposed to play a role in the etiology of autism. This hypothesis is supported by the discovery of increased MECP2 promoter methylation associated with decreased MeCP2 protein expression in autism male brain. To further understand the influence of female X chromosome inactivation (XCI) and neighboring methylation patterns on aberrant MECP2 promoter methylation in autism, multiple methylation analyses were performed on brain and blood samples from individuals with autism. Bisulfite sequencing analyses of a region 0.6 kb upstream of MECP2 in brain DNA samples revealed an abrupt transition from a highly methylated region in both sexes to a region unmethylated in males and subject to XCI in females. Chromatin immunoprecipitation analysis demonstrated that the CCCTC-binding factor (CTCF) is bound to this transition region in neuronal cells, consistent with a chromatin boundary at the methylation transition. Male autism brain DNA samples displayed a slight increase in methylation in this transition region, suggesting a possible aberrant spreading of methylation into the MECP2 promoter in autism males across this boundary element. In addition, autistic female brain DNA samples showed evidence for aberrant MECP2 promoter methylation as an increase in the number of bisulfite sequenced clones with undefined XCI status for MECP2 but not androgen receptor (AR). To further investigate the specificity of MECP2 methylation alterations in autism, blood DNA samples from females and mothers of males with autism were also examined for XCI skewing at AR, but no significant increase in XCI skewing was observed compared to controls. These results suggest that the aberrant MECP2 methylation in autism brain DNA samples is due to locus-specific rather than global X chromosome methylation changes. En ligne : http://dx.doi.org/10.1002/aur.24 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=931 Minor physical anomalies in children with autism spectrum disorders / Kathleen ANGKUSTSIRI in Autism, 15-6 (November 2011)
[article]
Titre : Minor physical anomalies in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Kathleen ANGKUSTSIRI, Auteur ; Paula KRAKOWIAK, Auteur ; Billur MOGHADDAM, Auteur ; Terrance WARDINSKY, Auteur ; Jerald GARDNER, Auteur ; Nareg KALAMKARIAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; David J. HANSEN, Auteur Année de publication : 2011 Article en page(s) : p.746-760 Langues : Anglais (eng) Mots-clés : autism dysmorphology minor physical anomalies Index. décimale : PER Périodiques Résumé : Objective: There is clinical heterogeneity among the autism spectrum disorders (ASD). The presence of dysmorphology (minor physical anomalies; MPAs) is one possible tool for defining a clinically relevant subset in ASD. This study employs an adaptation of Miles and Hillman’s (2000) classifications by using photographs to identify a subgroup with significant dysmorphology among children with ASD, typical development (TYP), and developmental delay (DD). Method: Children with ASD, DD, and TYP between 2 and 5 years old were part of the CHARGE Study. Pediatric specialists blinded to diagnostic group classified photographs based on the number of MPAs present: ‘dysmorphic’ if >3 and ‘nondysmorphic’ if <3 MPAs. Results: Photographs for 324 children were included. Significantly more children with ASD were classified as dysmorphic compared to TYP children (p = .007). In children with ASD, seizures were more prevalent in those rated dysmorphic (p = .005). Frequencies were similar between ASD versus DD (p = .19) after removing those with known syndromes. Conclusion: Photographic assessment can be used to detect generalized dysmorphology in children who are often difficult to examine. This has clinical relevance, as children with multiple MPAs can be identified through the use of photographs and prioritized for investigation of brain abnormalities and underlying genetic disorders. En ligne : http://dx.doi.org/10.1177/1362361310397620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149
in Autism > 15-6 (November 2011) . - p.746-760[article] Minor physical anomalies in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Kathleen ANGKUSTSIRI, Auteur ; Paula KRAKOWIAK, Auteur ; Billur MOGHADDAM, Auteur ; Terrance WARDINSKY, Auteur ; Jerald GARDNER, Auteur ; Nareg KALAMKARIAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; David J. HANSEN, Auteur . - 2011 . - p.746-760.
Langues : Anglais (eng)
in Autism > 15-6 (November 2011) . - p.746-760
Mots-clés : autism dysmorphology minor physical anomalies Index. décimale : PER Périodiques Résumé : Objective: There is clinical heterogeneity among the autism spectrum disorders (ASD). The presence of dysmorphology (minor physical anomalies; MPAs) is one possible tool for defining a clinically relevant subset in ASD. This study employs an adaptation of Miles and Hillman’s (2000) classifications by using photographs to identify a subgroup with significant dysmorphology among children with ASD, typical development (TYP), and developmental delay (DD). Method: Children with ASD, DD, and TYP between 2 and 5 years old were part of the CHARGE Study. Pediatric specialists blinded to diagnostic group classified photographs based on the number of MPAs present: ‘dysmorphic’ if >3 and ‘nondysmorphic’ if <3 MPAs. Results: Photographs for 324 children were included. Significantly more children with ASD were classified as dysmorphic compared to TYP children (p = .007). In children with ASD, seizures were more prevalent in those rated dysmorphic (p = .005). Frequencies were similar between ASD versus DD (p = .19) after removing those with known syndromes. Conclusion: Photographic assessment can be used to detect generalized dysmorphology in children who are often difficult to examine. This has clinical relevance, as children with multiple MPAs can be identified through the use of photographs and prioritized for investigation of brain abnormalities and underlying genetic disorders. En ligne : http://dx.doi.org/10.1177/1362361310397620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study / Tony CHARMAN in Autism Research, 10-1 (January 2017)
[article]
Titre : Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study Type de document : Texte imprimé et/ou numérique Auteurs : Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.169-178 Langues : Anglais (eng) Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.169-178[article] Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study [Texte imprimé et/ou numérique] / Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.169-178.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.169-178
Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Parental Occupational Exposures and Autism Spectrum Disorder / Erin MCCANLIES in Journal of Autism and Developmental Disorders, 42-11 (November 2012)
[article]
Titre : Parental Occupational Exposures and Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Erin MCCANLIES, Auteur ; Desta FEKEDULEGN, Auteur ; Anna MNATSAKANOVA, Auteur ; Cecil BURCHFIEL, Auteur ; Wayne SANDERSON, Auteur ; Luenda CHARLES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Article en page(s) : p.2323-2334 Langues : Anglais (eng) Mots-clés : Autism Autism spectrum disorder Parental exposures Parent Occupation Exposure Index. décimale : PER Périodiques Résumé : Both self-report and industrial hygienist (IH) assessed parental occupational information were used in this pilot study in which 174 families (93 children with ASD and 81 unaffected children) enrolled in the Childhood Autism Risks from Genetics and Environment study participated. IH results indicated exposures to lacquer, varnish, and xylene occurred more often in the parents of children with ASD compared to the parents of unaffected children. Parents of children with ASD were more likely to report exposures to asphalt and solvents compared to parents of unaffected children. This study was limited by the small sample size, but results suggest that workplace exposures to some chemicals may be important in the etiology of ASD and deserve further investigation. En ligne : http://dx.doi.org/10.1007/s10803-012-1468-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2323-2334[article] Parental Occupational Exposures and Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Erin MCCANLIES, Auteur ; Desta FEKEDULEGN, Auteur ; Anna MNATSAKANOVA, Auteur ; Cecil BURCHFIEL, Auteur ; Wayne SANDERSON, Auteur ; Luenda CHARLES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - p.2323-2334.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2323-2334
Mots-clés : Autism Autism spectrum disorder Parental exposures Parent Occupation Exposure Index. décimale : PER Périodiques Résumé : Both self-report and industrial hygienist (IH) assessed parental occupational information were used in this pilot study in which 174 families (93 children with ASD and 81 unaffected children) enrolled in the Childhood Autism Risks from Genetics and Environment study participated. IH results indicated exposures to lacquer, varnish, and xylene occurred more often in the parents of children with ASD compared to the parents of unaffected children. Parents of children with ASD were more likely to report exposures to asphalt and solvents compared to parents of unaffected children. This study was limited by the small sample size, but results suggest that workplace exposures to some chemicals may be important in the etiology of ASD and deserve further investigation. En ligne : http://dx.doi.org/10.1007/s10803-012-1468-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 Prenatal and Perinatal Risk Factors for Autism in China / Xin ZHANG in Journal of Autism and Developmental Disorders, 40-11 (November 2010)
PermalinkPrenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study / Emily E. JOYCE in Autism Research, 15-5 (May 2022)
PermalinkReduced levels of immunoglobulin in children with autism correlates with behavioral symptoms / Luke HEUER in Autism Research, 1-5 (October 2008)
PermalinkSerotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy / Rebecca A. HARRINGTON in Autism Research, 6-3 (June 2013)
PermalinkSociodemographic Disparities in Intervention Service Utilization in Families of Children with Autism Spectrum Disorder / Cathina T. NGUYEN in Journal of Autism and Developmental Disorders, 46-12 (December 2016)
PermalinkThe Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies / Rachel VECCHIONE in Journal of Autism and Developmental Disorders, 51-2 (February 2021)
PermalinkThe Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI) / Katharine K. BRIEGER in Journal of Autism and Developmental Disorders, 52-6 (June 2022)
PermalinkThe Environment in Autism Spectrum Disorders / Kristen LYALL
PermalinkThe joint effect of air pollution exposure and copy number variation on risk for autism / Dokyoon KIM in Autism Research, 10-9 (September 2017)
PermalinkThe onset of autism: patterns of symptom emergence in the first years of life / Sally OZONOFF in Autism Research, 1-6 (December 2008)
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