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Auteur Raphael BERNIER |
Documents disponibles écrits par cet auteur (49)
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Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism / Sara Jane WEBB in Journal of Autism and Developmental Disorders, 45-2 (February 2015)
[article]
Titre : Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sara Jane WEBB, Auteur ; Raphael BERNIER, Auteur ; Heather A. HENDERSON, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Matthew D. LERNER, Auteur ; James C. MCPARTLAND, Auteur ; Charles A. NELSON, Auteur ; Donald C. ROJAS, Auteur ; Jeanne TOWNSEND, Auteur ; Marissa A. WESTERFIELD, Auteur Article en page(s) : p.425-443 Langues : Anglais (eng) Mots-clés : EEG Electrophysiology ERP Event-related potentials MEG Magnetoencephalography Autism ASD Guidelines Index. décimale : PER Périodiques Résumé : The EEG reflects the activation of large populations of neurons that act in synchrony and propagate to the scalp surface. This activity reflects both the brain’s background electrical activity and when the brain is being challenged by a task. Despite strong theoretical and methodological arguments for the use of EEG in understanding the neural correlates of autism, the practice of collecting, processing and evaluating EEG data is complex. Scientists should take into consideration both the nature of development in autism given the life-long, pervasive course of the disorder and the disability of altered or atypical social, communicative, and motor behaviors, all of which require accommodations to traditional EEG environments and paradigms. This paper presents guidelines for the recording, analyzing, and interpreting of EEG data with participants with autism. The goal is to articulate a set of scientific standards as well as methodological considerations that will increase the general field’s understanding of EEG methods, provide support for collaborative projects, and contribute to the evaluation of results and conclusions. En ligne : http://dx.doi.org/10.1007/s10803-013-1916-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.425-443[article] Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism [Texte imprimé et/ou numérique] / Sara Jane WEBB, Auteur ; Raphael BERNIER, Auteur ; Heather A. HENDERSON, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Matthew D. LERNER, Auteur ; James C. MCPARTLAND, Auteur ; Charles A. NELSON, Auteur ; Donald C. ROJAS, Auteur ; Jeanne TOWNSEND, Auteur ; Marissa A. WESTERFIELD, Auteur . - p.425-443.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.425-443
Mots-clés : EEG Electrophysiology ERP Event-related potentials MEG Magnetoencephalography Autism ASD Guidelines Index. décimale : PER Périodiques Résumé : The EEG reflects the activation of large populations of neurons that act in synchrony and propagate to the scalp surface. This activity reflects both the brain’s background electrical activity and when the brain is being challenged by a task. Despite strong theoretical and methodological arguments for the use of EEG in understanding the neural correlates of autism, the practice of collecting, processing and evaluating EEG data is complex. Scientists should take into consideration both the nature of development in autism given the life-long, pervasive course of the disorder and the disability of altered or atypical social, communicative, and motor behaviors, all of which require accommodations to traditional EEG environments and paradigms. This paper presents guidelines for the recording, analyzing, and interpreting of EEG data with participants with autism. The goal is to articulate a set of scientific standards as well as methodological considerations that will increase the general field’s understanding of EEG methods, provide support for collaborative projects, and contribute to the evaluation of results and conclusions. En ligne : http://dx.doi.org/10.1007/s10803-013-1916-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder / S. ACKERMAN in Journal of Autism and Developmental Disorders, 47-11 (November 2017)
[article]
Titre : Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. ACKERMAN, Auteur ; S. SCHOENBRUN, Auteur ; C. HUDAC, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.3489-3496 Langues : Anglais (eng) Mots-clés : Asd Antidepressants Autism Genetics Ssri Index. décimale : PER Périodiques Résumé : To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains. We consider a "two-hit" model in which one variable lays the foundation for an initial risk which is compounded by a second variable. En ligne : http://dx.doi.org/10.1007/s10803-017-3246-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3489-3496[article] Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. ACKERMAN, Auteur ; S. SCHOENBRUN, Auteur ; C. HUDAC, Auteur ; Raphael BERNIER, Auteur . - p.3489-3496.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3489-3496
Mots-clés : Asd Antidepressants Autism Genetics Ssri Index. décimale : PER Périodiques Résumé : To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains. We consider a "two-hit" model in which one variable lays the foundation for an initial risk which is compounded by a second variable. En ligne : http://dx.doi.org/10.1007/s10803-017-3246-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 Language and Aggressive Behaviors in Male and Female Youth with Autism Spectrum Disorder / E. NEUHAUS in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
[article]
Titre : Language and Aggressive Behaviors in Male and Female Youth with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. NEUHAUS, Auteur ; V. Y. KANG, Auteur ; A. KRESSE, Auteur ; S. CORRIGAN, Auteur ; Elizabeth H. AYLWARD, Auteur ; Raphael BERNIER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; A. JACK, Auteur ; S. JESTE, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Kevin A. PELPHREY, Auteur ; S. J. WEBB, Auteur Article en page(s) : p.454-462 Langues : Anglais (eng) Mots-clés : Adolescent Aggression Autism Spectrum Disorder Child Communication Female Humans Language Male Asd Autism Externalizing behaviors Gender Sex differences Index. décimale : PER Périodiques Résumé : Aggressive behaviors are common among youth with autism spectrum disorder (ASD) and correlate with pervasive social-emotional difficulties. Communication skill is an important correlate of disruptive behavior in typical development, and clarification of links between communication and aggression in ASD may inform intervention methods. We investigate child/family factors and communication in relation to aggression among 145 individuals with ASD (65 female; ages 8-17 years). Overall, more severe aggression was associated with younger age, lower family income, and difficulties with communication skills. However, this pattern of results was driven by males, and aggression was unrelated to child or family characteristics for females. Future work should incorporate these predictors in conjunction with broader contextual factors to understand aggressive behavior in females with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04773-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.454-462[article] Language and Aggressive Behaviors in Male and Female Youth with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / E. NEUHAUS, Auteur ; V. Y. KANG, Auteur ; A. KRESSE, Auteur ; S. CORRIGAN, Auteur ; Elizabeth H. AYLWARD, Auteur ; Raphael BERNIER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; A. JACK, Auteur ; S. JESTE, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Kevin A. PELPHREY, Auteur ; S. J. WEBB, Auteur . - p.454-462.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.454-462
Mots-clés : Adolescent Aggression Autism Spectrum Disorder Child Communication Female Humans Language Male Asd Autism Externalizing behaviors Gender Sex differences Index. décimale : PER Périodiques Résumé : Aggressive behaviors are common among youth with autism spectrum disorder (ASD) and correlate with pervasive social-emotional difficulties. Communication skill is an important correlate of disruptive behavior in typical development, and clarification of links between communication and aggression in ASD may inform intervention methods. We investigate child/family factors and communication in relation to aggression among 145 individuals with ASD (65 female; ages 8-17 years). Overall, more severe aggression was associated with younger age, lower family income, and difficulties with communication skills. However, this pattern of results was driven by males, and aggression was unrelated to child or family characteristics for females. Future work should incorporate these predictors in conjunction with broader contextual factors to understand aggressive behavior in females with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04773-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Linking social motivation with social skill: The role of emotion dysregulation in autism spectrum disorder / Emily NEUHAUS in Development and Psychopathology, 31-3 (August 2019)
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Titre : Linking social motivation with social skill: The role of emotion dysregulation in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Emily NEUHAUS, Auteur ; Sara J. WEBB, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.931-943 Langues : Anglais (eng) Mots-clés : autism emotion dysregulation externalizing internalizing social motivation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with pervasive social deficits as well as marked emotion dysregulation across the life span. Decreased social motivation accounts in part for social difficulties, but factors moderating its influence are not fully understood. In this paper, we (a) characterize social and emotional functioning among children and adolescents with ASD, (b) explore contributions of social motivation and emotion dysregulation to social skill, and (c) consider biological sex and intellectual functioning as moderators of these associations. In a sample of 2,079 children and adolescents with ASD from the Simons Simplex Collection, we document direct effects of social motivation, internalizing symptoms, aggression, attention problems, irritability, and self-injurious behavior on children's social skills. Furthermore, dysregulation in several domains moderated the association between social motivation and social skill, suggesting a blunting effect on social motivation in the context of emotional difficulties. Moreover, when considering only individuals with intellectual skills in the average range or higher, biological sex further moderated these associations. Findings add to our understanding of social–emotional processes in ASD, suggest emotion dysregulation as a target of intervention in the service of social skill improvements, and build on efforts to understand sources of individual difference that contribute to heterogeneity among individuals with ASD. En ligne : http://dx.doi.org/10.1017/S0954579419000361 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403
in Development and Psychopathology > 31-3 (August 2019) . - p.931-943[article] Linking social motivation with social skill: The role of emotion dysregulation in autism spectrum disorder [Texte imprimé et/ou numérique] / Emily NEUHAUS, Auteur ; Sara J. WEBB, Auteur ; Raphael BERNIER, Auteur . - p.931-943.
Langues : Anglais (eng)
in Development and Psychopathology > 31-3 (August 2019) . - p.931-943
Mots-clés : autism emotion dysregulation externalizing internalizing social motivation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with pervasive social deficits as well as marked emotion dysregulation across the life span. Decreased social motivation accounts in part for social difficulties, but factors moderating its influence are not fully understood. In this paper, we (a) characterize social and emotional functioning among children and adolescents with ASD, (b) explore contributions of social motivation and emotion dysregulation to social skill, and (c) consider biological sex and intellectual functioning as moderators of these associations. In a sample of 2,079 children and adolescents with ASD from the Simons Simplex Collection, we document direct effects of social motivation, internalizing symptoms, aggression, attention problems, irritability, and self-injurious behavior on children's social skills. Furthermore, dysregulation in several domains moderated the association between social motivation and social skill, suggesting a blunting effect on social motivation in the context of emotional difficulties. Moreover, when considering only individuals with intellectual skills in the average range or higher, biological sex further moderated these associations. Findings add to our understanding of social–emotional processes in ASD, suggest emotion dysregulation as a target of intervention in the service of social skill improvements, and build on efforts to understand sources of individual difference that contribute to heterogeneity among individuals with ASD. En ligne : http://dx.doi.org/10.1017/S0954579419000361 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 Modulation of mu attenuation to social stimuli in children and adults with 16p11.2 deletions and duplications / C. M. HUDAC in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
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Titre : Modulation of mu attenuation to social stimuli in children and adults with 16p11.2 deletions and duplications Type de document : Texte imprimé et/ou numérique Auteurs : C. M. HUDAC, Auteur ; A. KRESSE, Auteur ; Benjamin AARONSON, Auteur ; Trent D. DESCHAMPS, Auteur ; S. J. WEBB, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.25 Langues : Anglais (eng) Mots-clés : 16p11.2 Autism spectrum disorder (ASD) Copy number variation (CNV) Electroencephalogram (EEG) Molecular subtyping Mu attenuation Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Copy number variations (CNV) within the recurrent ~600 kb chromosomal locus of 16p11.2 are associated with a wide range of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, little is known about the social brain phenotype of 16p11.2 CNV and how this phenotype is related to the social impairments associated with CNVs at this locus. The aim of this preliminary study was to use molecular subtyping to establish the social brain phenotype of individuals with 16p11.2 CNV and how these patterns relate to typical development and ASD. METHODS: We evaluated the social brain phenotype as expressed by mu attenuation in 48 children and adults characterized as duplication carriers (n = 12), deletion carriers (n = 12), individuals with idiopathic ASD (n = 8), and neurotypical controls (n = 16). Participants watched videos containing social and nonsocial motion during electroencephalogram (EEG) acquisition. RESULTS: Overall, only the typical group exhibited predicted patterns of mu modulation to social information (e.g., greater mu attenuation for social than nonsocial motion). Both 16p11.2 CNV groups exhibited more mu attenuation for nonsocial than social motion. The ASD group did not discriminate between conditions and demonstrated less mu attenuation compared to the typical and duplication carriers. Single-trial analysis indicated that mu attenuation decreased over time more rapidly for 16p11.2 CNV groups than the typical group. The duplication group did not diverge from typical patterns of mu attenuation until after initial exposure. CONCLUSIONS: These results indicate atypical but unique patterns of mu attenuation for deletion and duplication carriers, highlighting the need to continue characterizing the social brain phenotype associated with 16p11.2 CNVs. En ligne : http://dx.doi.org/10.1186/s11689-015-9118-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.25[article] Modulation of mu attenuation to social stimuli in children and adults with 16p11.2 deletions and duplications [Texte imprimé et/ou numérique] / C. M. HUDAC, Auteur ; A. KRESSE, Auteur ; Benjamin AARONSON, Auteur ; Trent D. DESCHAMPS, Auteur ; S. J. WEBB, Auteur ; Raphael BERNIER, Auteur . - p.25.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.25
Mots-clés : 16p11.2 Autism spectrum disorder (ASD) Copy number variation (CNV) Electroencephalogram (EEG) Molecular subtyping Mu attenuation Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Copy number variations (CNV) within the recurrent ~600 kb chromosomal locus of 16p11.2 are associated with a wide range of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, little is known about the social brain phenotype of 16p11.2 CNV and how this phenotype is related to the social impairments associated with CNVs at this locus. The aim of this preliminary study was to use molecular subtyping to establish the social brain phenotype of individuals with 16p11.2 CNV and how these patterns relate to typical development and ASD. METHODS: We evaluated the social brain phenotype as expressed by mu attenuation in 48 children and adults characterized as duplication carriers (n = 12), deletion carriers (n = 12), individuals with idiopathic ASD (n = 8), and neurotypical controls (n = 16). Participants watched videos containing social and nonsocial motion during electroencephalogram (EEG) acquisition. RESULTS: Overall, only the typical group exhibited predicted patterns of mu modulation to social information (e.g., greater mu attenuation for social than nonsocial motion). Both 16p11.2 CNV groups exhibited more mu attenuation for nonsocial than social motion. The ASD group did not discriminate between conditions and demonstrated less mu attenuation compared to the typical and duplication carriers. Single-trial analysis indicated that mu attenuation decreased over time more rapidly for 16p11.2 CNV groups than the typical group. The duplication group did not diverge from typical patterns of mu attenuation until after initial exposure. CONCLUSIONS: These results indicate atypical but unique patterns of mu attenuation for deletion and duplication carriers, highlighting the need to continue characterizing the social brain phenotype associated with 16p11.2 CNVs. En ligne : http://dx.doi.org/10.1186/s11689-015-9118-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 Next Generation Sequencing Mitochondrial DNA Analysis in Autism Spectrum Disorder / Ashok PATOWARY in Autism Research, 10-8 (August 2017)
PermalinkPatterns of intervention utilization among school-aged children on the autism spectrum: Findings from a multi-site research consortium / Aksheya SRIDHAR in Research in Autism Spectrum Disorders, 94 (June 2022)
PermalinkPermalinkQuantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale / Geraldine DAWSON in Journal of Autism and Developmental Disorders, 37-3 (March 2007)
PermalinkSeverity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound / Sara Jane WEBB in Autism Research, 10-3 (March 2017)
PermalinkSex Differences in Autism: Examining Intrinsic and Extrinsic Factors in Children and Adolescents Enrolled in a National ASD Cohort / Emily F. DILLON in Journal of Autism and Developmental Disorders, 53-4 (April 2023)
PermalinkSocial attention: a possible early indicator of efficacy in autism clinical trials / G. DAWSON in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)
PermalinkSocial Motivation Across Multiple Measures: Caregiver-Report of Children with Autism Spectrum Disorder / Emily NEUHAUS in Autism Research, 14-2 (February 2021)
PermalinkThe autism biomarkers consortium for clinical trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials / Frederick SHIC in Molecular Autism, 13 (2022)
PermalinkThe Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses / Joseph D. BUXBAUM in Molecular Autism, (May 2014)
PermalinkThe autism spectrum phenotype in ADNP syndrome / Anne B. ARNETT in Autism Research, 11-9 (September 2018)
PermalinkThe Broader Autism Phenotype and Its Implications on the Etiology and Treatment of Autism Spectrum Disorders / Jennifer GERDTS in Autism Research and Treatment, (May 2011)
PermalinkThe Broader Autism Phenotype in Simplex and Multiplex Families / Jennifer GERDTS in Journal of Autism and Developmental Disorders, 43-7 (July 2013)
PermalinkThe diagnosis conundrum: Comparison of crowdsourced and expert assessments of toddlers with high and low risk of autism spectrum disorder / E. MYERS in Autism Research, 11-12 (December 2018)
PermalinkThe Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders / Benjamin AARONSON in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
PermalinkThe gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences / G. A. MCQUAID in Autism, 25-6 (August 2021)
PermalinkThe Role of Mirror Neuron Dysfunction in Autism / Raphael BERNIER
PermalinkThe Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study / Erin C. BARNEY ; Adam J. NAPLES ; Kelsey J. DOMMER ; Shou An CHANG ; Beibin LI ; Takumi MCALLISTER ; Adham ATYABI ; Quan WANG ; Raphael BERNIER ; Geraldine DAWSON ; James DZIURA ; Susan FAJA ; Shafali Spurling JESTE ; Michael MURIAS ; Scott P. JOHNSON ; Maura SABATOS-DEVITO ; Gerhard HELLEMAN ; Damla SENTURK ; Catherine A. SUGAR ; Sara Jane WEBB ; James C. MCPARTLAND ; Katarzyna CHAWARSKA ; The Autism Biomarkers Consortium for Clinical TRIALS in Autism Research, 16-11 (November 2023)
PermalinkTranscriptional subtyping explains phenotypic variability in genetic subtypes of autism spectrum disorder / Sandy TRINH in Development and Psychopathology, 32-4 (October 2020)
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