Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning / Kathryn L. HUMPHREYS in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1174-1182 Titre : Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn L. HUMPHREYS, Auteur ; Katharina KIRCANSKI, Auteur ; Natalie L. COLICH, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1174-1182 Langues : Anglais (eng) Mots-clés : Early life stress  attentional bias  fearful faces  social problems Index. décimale : PER Périodiques Résumé : Background Early life stress is associated with poorer social functioning. Attentional biases in response to threat-related cues, linked to both early experience and psychopathology, may explain this association. To date, however, no study has examined attentional biases to fearful facial expressions as a function of early life stress or examined these biases as a potential mediator of the relation between early life stress and social problems. Methods In a sample of 154 children (ages 9–13 years) we examined the associations among interpersonal early life stressors (i.e., birth through age 6 years), attentional biases to emotional facial expressions using a dot-probe task, and social functioning on the Child Behavior Checklist. Results High levels of early life stress were associated with both greater levels of social problems and an attentional bias away from fearful facial expressions, even after accounting for stressors occurring in later childhood. No biases were found for happy or sad facial expressions as a function of early life stress. Finally, attentional biases to fearful faces mediated the association between early life stress and social problems. Conclusions Attentional avoidance of fearful facial expressions, evidenced by a bias away from these stimuli, may be a developmental response to early adversity and link the experience of early life stress to poorer social functioning. En ligne : http://dx.doi.org/10.1111/jcpp.12607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning [Texte imprimé et/ou numérique] / Kathryn L. HUMPHREYS, Auteur ; Katharina KIRCANSKI, Auteur ; Natalie L. COLICH, Auteur ; Ian H. GOTLIB, Auteur . - p.1174-1182. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1174-1182 Mots-clés : Early life stress  attentional bias  fearful faces  social problems Index. décimale : PER Périodiques Résumé : Background Early life stress is associated with poorer social functioning. Attentional biases in response to threat-related cues, linked to both early experience and psychopathology, may explain this association. To date, however, no study has examined attentional biases to fearful facial expressions as a function of early life stress or examined these biases as a potential mediator of the relation between early life stress and social problems. Methods In a sample of 154 children (ages 9–13 years) we examined the associations among interpersonal early life stressors (i.e., birth through age 6 years), attentional biases to emotional facial expressions using a dot-probe task, and social functioning on the Child Behavior Checklist. Results High levels of early life stress were associated with both greater levels of social problems and an attentional bias away from fearful facial expressions, even after accounting for stressors occurring in later childhood. No biases were found for happy or sad facial expressions as a function of early life stress. Finally, attentional biases to fearful faces mediated the association between early life stress and social problems. Conclusions Attentional avoidance of fearful facial expressions, evidenced by a bias away from these stimuli, may be a developmental response to early adversity and link the experience of early life stress to poorer social functioning. En ligne : http://dx.doi.org/10.1111/jcpp.12607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty / Katharina KIRCANSKI in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Titre : Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty Type de document : Texte imprimé et/ou numérique Auteurs : Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1011-1022 Langues : Anglais (eng) Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty [Texte imprimé et/ou numérique] / Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1011-1022. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism / Jennifer H. PFEIFER in Journal of Autism and Developmental Disorders, 43-2 (February 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285 Titre : Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.272-285 Langues : (Eng) Mots-clés : Autism  Self  Ventral mPFC  Anterior insula  Middle cingulate cortex  Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 [article] Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism [Texte imprimé et/ou numérique] / Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur . - p.272-285. Langues : (Eng) in Journal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285 Mots-clés : Autism  Self  Ventral mPFC  Anterior insula  Middle cingulate cortex  Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188

The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence / Natalie L. COLICH in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Titre : The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1851-1864 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence [Texte imprimé et/ou numérique] / Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1851-1864. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Time Reproduction Performance Is Associated With Age and Working Memory in High-Functioning Youth With Autism Spectrum Disorder / Laurie A. BRENNER in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.29-37 Titre : Time Reproduction Performance Is Associated With Age and Working Memory in High-Functioning Youth With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Laurie A. BRENNER, Auteur ; Vivian H. SHIH, Auteur ; Natalie L. COLICH, Auteur ; Catherine A. SUGAR, Auteur ; Carrie E. BEARDEN, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.29-37 Langues : Anglais (eng) Mots-clés : temporal processing  time estimation  inattention/hyperactivity Index. décimale : PER Périodiques Résumé : Impaired temporal processing has historically been viewed as a hallmark feature of attention deficit hyperactivity disorder. Recent evidence suggests temporal processing deficits may also be characteristic of autism spectrum disorder (ASD). However, little is known about the factors that impact temporal processing in children with ASD. The purpose of this study was to assess the effects of co-morbid attention problems, working memory (WM), age, and their interactions, on time reproduction in youth with and without ASD. Twenty-seven high-functioning individuals with ASD and 25 demographically comparable typically developing individuals (ages 9–17; 85% male) were assessed on measures of time reproduction, auditory WM, and inattention/hyperactivity. The time reproduction task required depression of a computer key to mimic interval durations of 4, 8, 12, 16, or 20?sec. Mixed effects regression analyses were used to model accuracy and variability of time reproduction as functions of diagnostic group, interval duration, age, WM, and inattention/hyperactivity. A significant group by age interaction was detected for accuracy, with the deficit in the ASD group being greater in younger children. There was a significant group by WM interaction for consistency, with the effects of poor WM on performance consistency being more pronounced in youth with ASD. All participants tended to underestimate longer interval durations and to be less consistent for shorter interval durations; these effects appeared more pronounced in those who were younger or who had poorer WM performance. Inattention/hyperactivity symptoms in the ASD group were not related to either accuracy or consistency. This study highlights the potential value of temporal processing as an intermediate trait of relevance to multiple neurodevelopmental disorders. Autism Res 2015, 8: 29–37. En ligne : http://dx.doi.org/10.1002/aur.1401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Time Reproduction Performance Is Associated With Age and Working Memory in High-Functioning Youth With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Laurie A. BRENNER, Auteur ; Vivian H. SHIH, Auteur ; Natalie L. COLICH, Auteur ; Catherine A. SUGAR, Auteur ; Carrie E. BEARDEN, Auteur ; Mirella DAPRETTO, Auteur . - p.29-37. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.29-37 Mots-clés : temporal processing  time estimation  inattention/hyperactivity Index. décimale : PER Périodiques Résumé : Impaired temporal processing has historically been viewed as a hallmark feature of attention deficit hyperactivity disorder. Recent evidence suggests temporal processing deficits may also be characteristic of autism spectrum disorder (ASD). However, little is known about the factors that impact temporal processing in children with ASD. The purpose of this study was to assess the effects of co-morbid attention problems, working memory (WM), age, and their interactions, on time reproduction in youth with and without ASD. Twenty-seven high-functioning individuals with ASD and 25 demographically comparable typically developing individuals (ages 9–17; 85% male) were assessed on measures of time reproduction, auditory WM, and inattention/hyperactivity. The time reproduction task required depression of a computer key to mimic interval durations of 4, 8, 12, 16, or 20?sec. Mixed effects regression analyses were used to model accuracy and variability of time reproduction as functions of diagnostic group, interval duration, age, WM, and inattention/hyperactivity. A significant group by age interaction was detected for accuracy, with the deficit in the ASD group being greater in younger children. There was a significant group by WM interaction for consistency, with the effects of poor WM on performance consistency being more pronounced in youth with ASD. All participants tended to underestimate longer interval durations and to be less consistent for shorter interval durations; these effects appeared more pronounced in those who were younger or who had poorer WM performance. Inattention/hyperactivity symptoms in the ASD group were not related to either accuracy or consistency. This study highlights the potential value of temporal processing as an intermediate trait of relevance to multiple neurodevelopmental disorders. Autism Res 2015, 8: 29–37. En ligne : http://dx.doi.org/10.1002/aur.1401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

---

1 (1 - 5 / 5)