Dépouillements

Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder / Esen YILDIRIM DEMIRDÖ?EN in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102327 Titre : Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Esen YILDIRIM DEMIRDÖ?EN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERI?, Auteur ; Nezahat KURT, Auteur ; Neslihan YÜCE, Auteur Article en page(s) : p.102327 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Hypoxia-inducible factor-1 alpha (HIF-1?)  Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1? and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1? and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1? and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1? and apelin serum levels were compared between groups. Additionally, correlations between HIF-1? and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1? and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r = ?0.430, p = 0.018). Serum HIF-1? levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1? and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1?, apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder [Texte imprimé et/ou numérique] / Esen YILDIRIM DEMIRDÖ?EN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERI?, Auteur ; Nezahat KURT, Auteur ; Neslihan YÜCE, Auteur . - p.102327. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102327 Mots-clés : Autism spectrum disorder  Hypoxia-inducible factor-1 alpha (HIF-1?)  Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1? and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1? and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1? and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1? and apelin serum levels were compared between groups. Additionally, correlations between HIF-1? and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1? and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r = ?0.430, p = 0.018). Serum HIF-1? levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1? and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1?, apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Effects of autistic traits on prosocial tendencies: The chain mediating role of fear of missing out and interpersonal security / Qin LUO in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102328 Titre : Effects of autistic traits on prosocial tendencies: The chain mediating role of fear of missing out and interpersonal security Type de document : Texte imprimé et/ou numérique Auteurs : Qin LUO, Auteur ; Hai LI, Auteur ; Yaojie LIN, Auteur ; Rongqing HU, Auteur ; Hong LI, Auteur ; Shuo ZHAO, Auteur Article en page(s) : p.102328 Langues : Anglais (eng) Mots-clés : Individuals with autistic traits  Prosocial tendencies  Relatedness needs  Fear of missing out  Interpersonal security  College students Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that the defining features of autism spectrum disorder are present to varying degrees throughout the general population. Therefore, exploring factors associated with prosocial behavior in individuals with elevated levels of autistic traits may offer valuable insights into both autistic traits and prosocial behavior. In this study, our goal was to determine the relationship between autistic traits and prosocial tendencies, examining the cascading mediating effects of internal factors related to the need for connection, including fear of missing out (FoMO) and interpersonal security. We utilized the Autism Quotient (AQ) scale, the FoMO scale, the College Students' Interpersonal Security Questionnaire (CSISQ), and the Prosocial Tendencies Measure (PTM) in a paper-and-pencil survey administered to 408 college and graduate students in Guangdong Province, China. The results indicated a fully mediated relationship between autistic traits and prosocial tendencies by FoMO and interpersonal security. These findings are interpreted within the framework of social-psychological theory, suggesting that high levels of autistic traits may contribute to interpersonal problems, exacerbating the FoMO, limiting social homogeneity, and reducing interpersonal security. These factors are closely related to prosocial tendencies. Simultaneously, elevated levels of autistic traits may influence interpersonal security, stemming from challenges in social interactions. Unmet psychological needs could potentially heighten anxiety levels, prompting individuals to become more self-focused and seek external compensation. This heightened fear of missing out and the depletion of psychological resources might be associated with a decline in prosocial tendencies. En ligne : https://doi.org/10.1016/j.rasd.2024.102328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Effects of autistic traits on prosocial tendencies: The chain mediating role of fear of missing out and interpersonal security [Texte imprimé et/ou numérique] / Qin LUO, Auteur ; Hai LI, Auteur ; Yaojie LIN, Auteur ; Rongqing HU, Auteur ; Hong LI, Auteur ; Shuo ZHAO, Auteur . - p.102328. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102328 Mots-clés : Individuals with autistic traits  Prosocial tendencies  Relatedness needs  Fear of missing out  Interpersonal security  College students Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that the defining features of autism spectrum disorder are present to varying degrees throughout the general population. Therefore, exploring factors associated with prosocial behavior in individuals with elevated levels of autistic traits may offer valuable insights into both autistic traits and prosocial behavior. In this study, our goal was to determine the relationship between autistic traits and prosocial tendencies, examining the cascading mediating effects of internal factors related to the need for connection, including fear of missing out (FoMO) and interpersonal security. We utilized the Autism Quotient (AQ) scale, the FoMO scale, the College Students' Interpersonal Security Questionnaire (CSISQ), and the Prosocial Tendencies Measure (PTM) in a paper-and-pencil survey administered to 408 college and graduate students in Guangdong Province, China. The results indicated a fully mediated relationship between autistic traits and prosocial tendencies by FoMO and interpersonal security. These findings are interpreted within the framework of social-psychological theory, suggesting that high levels of autistic traits may contribute to interpersonal problems, exacerbating the FoMO, limiting social homogeneity, and reducing interpersonal security. These factors are closely related to prosocial tendencies. Simultaneously, elevated levels of autistic traits may influence interpersonal security, stemming from challenges in social interactions. Unmet psychological needs could potentially heighten anxiety levels, prompting individuals to become more self-focused and seek external compensation. This heightened fear of missing out and the depletion of psychological resources might be associated with a decline in prosocial tendencies. En ligne : https://doi.org/10.1016/j.rasd.2024.102328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Factors associated with the job satisfaction of autistic adults / Shannon Crowley LAPOINT in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102330 Titre : Factors associated with the job satisfaction of autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : Shannon Crowley LAPOINT, Auteur Article en page(s) : p.102330 Langues : Anglais (eng) Mots-clés : Autism  Employment  Job satisfaction Index. décimale : PER Périodiques Résumé : Background Following high school graduation, autistic adults are more likely to be disengaged from participation in employment opportunities. The autistic individuals who do obtain jobs, often experience lower rates of employment, work fewer hours, and receive less pay when compared to other non-autistic adults. However, few researchers have explored outcomes associated with the satisfaction of autistic people while in the workplace. Method Therefore, this study aimed to determine the factors associated with the job satisfaction of autistic workers. Autistic adults who were at least 18 years of age, employed in the United States, and worked at least 10 h per week at the time of data collection were included in the current study. A linear regression was conducted to determine whether social support positively predicted the job satisfaction of autistic workers and mediation analysis was conducted to determine whether person-environment fit mediated the relationship between work volition and job satisfaction. Results 121 autistic employees completed a battery of assessments to determine the predictors associated with job satisfaction. A linear regression revealed that social support in the workplace was significantly associated with job satisfaction, and a mediation analysis demonstrated that person-environment fit partially mediated the relationship between work volition and job satisfaction. Conclusions The findings of this study suggest the need for more widespread training among employers and co-workers, to reframe current understandings of autistic people. With improved knowledge, acceptance, and support, the employment context may foster positive work experiences for autistic people. En ligne : https://doi.org/10.1016/j.rasd.2024.102330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Factors associated with the job satisfaction of autistic adults [Texte imprimé et/ou numérique] / Shannon Crowley LAPOINT, Auteur . - p.102330. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102330 Mots-clés : Autism  Employment  Job satisfaction Index. décimale : PER Périodiques Résumé : Background Following high school graduation, autistic adults are more likely to be disengaged from participation in employment opportunities. The autistic individuals who do obtain jobs, often experience lower rates of employment, work fewer hours, and receive less pay when compared to other non-autistic adults. However, few researchers have explored outcomes associated with the satisfaction of autistic people while in the workplace. Method Therefore, this study aimed to determine the factors associated with the job satisfaction of autistic workers. Autistic adults who were at least 18 years of age, employed in the United States, and worked at least 10 h per week at the time of data collection were included in the current study. A linear regression was conducted to determine whether social support positively predicted the job satisfaction of autistic workers and mediation analysis was conducted to determine whether person-environment fit mediated the relationship between work volition and job satisfaction. Results 121 autistic employees completed a battery of assessments to determine the predictors associated with job satisfaction. A linear regression revealed that social support in the workplace was significantly associated with job satisfaction, and a mediation analysis demonstrated that person-environment fit partially mediated the relationship between work volition and job satisfaction. Conclusions The findings of this study suggest the need for more widespread training among employers and co-workers, to reframe current understandings of autistic people. With improved knowledge, acceptance, and support, the employment context may foster positive work experiences for autistic people. En ligne : https://doi.org/10.1016/j.rasd.2024.102330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Sleep and daytime functioning in autistic teenagers: A psychological network approach / I. M. G. SCHOUWENAARS in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102332 Titre : Sleep and daytime functioning in autistic teenagers: A psychological network approach Type de document : Texte imprimé et/ou numérique Auteurs : I. M. G. SCHOUWENAARS, Auteur ; M. J. C. M. MAGNÉE, Auteur ; H. M. GEURTS, Auteur ; C. A. M. VAN BENNEKOM, Auteur ; S. PILLEN, Auteur ; L. J. WALDORP, Auteur ; T. F. BLANKEN, Auteur ; J. P. TEUNISSE, Auteur Article en page(s) : p.102332 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Sleep  Teenagers  Daytime functioning  Network approach Index. décimale : PER Périodiques Résumé : Background Although sleep problems in autistic teenagers are associated with impaired daytime functioning, it remains unclear how sleep and daytime functioning are related. Method We used a network approach to disentangle patterns between sleep, sleep hygiene, and daytime functioning. Over a three-week period, 31 autistic teenagers answered daily questions about sleep and daytime functioning. Sleep tracker data were collected from 14 of the teenagers. We preregistered the analysis plan for this study at AsPredicted (#34594; https://aspredicted.org/blind.php?x = 3c4t65). Results Perceived sleep quality seemed to be the most important sleep variable in relation to daytime functioning (self/parent/teacher reports). We also found that sleep onset latency, total sleep time, and wake time after sleep onset were related to daytime functioning, but mostly indirectly through perceived sleep quality. Conclusion These findings are important for developing sleep interventions because perceived sleep quality would be a logical target for increasing the likelihood of actually improving daytime functioning. En ligne : https://doi.org/10.1016/j.rasd.2024.102332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Sleep and daytime functioning in autistic teenagers: A psychological network approach [Texte imprimé et/ou numérique] / I. M. G. SCHOUWENAARS, Auteur ; M. J. C. M. MAGNÉE, Auteur ; H. M. GEURTS, Auteur ; C. A. M. VAN BENNEKOM, Auteur ; S. PILLEN, Auteur ; L. J. WALDORP, Auteur ; T. F. BLANKEN, Auteur ; J. P. TEUNISSE, Auteur . - p.102332. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102332 Mots-clés : Autism spectrum disorder  Sleep  Teenagers  Daytime functioning  Network approach Index. décimale : PER Périodiques Résumé : Background Although sleep problems in autistic teenagers are associated with impaired daytime functioning, it remains unclear how sleep and daytime functioning are related. Method We used a network approach to disentangle patterns between sleep, sleep hygiene, and daytime functioning. Over a three-week period, 31 autistic teenagers answered daily questions about sleep and daytime functioning. Sleep tracker data were collected from 14 of the teenagers. We preregistered the analysis plan for this study at AsPredicted (#34594; https://aspredicted.org/blind.php?x = 3c4t65). Results Perceived sleep quality seemed to be the most important sleep variable in relation to daytime functioning (self/parent/teacher reports). We also found that sleep onset latency, total sleep time, and wake time after sleep onset were related to daytime functioning, but mostly indirectly through perceived sleep quality. Conclusion These findings are important for developing sleep interventions because perceived sleep quality would be a logical target for increasing the likelihood of actually improving daytime functioning. En ligne : https://doi.org/10.1016/j.rasd.2024.102332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Perceptions of autistic and non-autistic adults in employment interviews: The role of impression management / Jade Eloise NORRIS in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102333 Titre : Perceptions of autistic and non-autistic adults in employment interviews: The role of impression management Type de document : Texte imprimé et/ou numérique Auteurs : Jade Eloise NORRIS, Auteur ; Jemma NICHOLSON, Auteur ; Rachel PROSSER, Auteur ; Jessica FARRELL, Auteur ; Anna REMINGTON, Auteur ; Laura CRANE, Auteur ; Laura HULL, Auteur ; Katie MARAS, Auteur Article en page(s) : p.102333 Langues : Anglais (eng) Mots-clés : Autism  Employment  Interviews  Impression management  Non-verbal  Behavioral Index. décimale : PER Périodiques Résumé : Background Social communication and interaction differences can make employment interviews particularly challenging for autistic people, who may be less able to modulate their Impression Management (IM). This makes autism a relevant test case of the extent to which behavioral IM influences perceptions of job candidates. Method Two studies are reported. In Study 1, lay-raters watched a video of autistic and non-autistic mock candidates' interviews, and assessed their verbal, non-verbal, and para-verbal behaviors, and likelihood of social approach/avoidance. In Study 2, the presence of behavioral cues was manipulated by using either the interview videos (behavioral cues present) or transcripts (cues absent). Employers rated their overall impression of the candidates (e.g., perceived confidence, conscientiousness, competence, communication skills, etc). Results In study 1, autistic candidates were perceived as having a more monotonous tone of voice, being less composed and focused, and displaying less natural eye contact and gestures than their non-autistic counterparts, and received lower ratings for likelihood of social approach. For non-autistic interviewees, relationships were also found between ratings for verbal, para-verbal, and non-verbal behaviors, and social awkwardness and attractiveness. In study 2, non-autistic (but not autistic) interviewees received higher ratings of their confidence and communication skills when assessed by video than by transcript, but this advantage was not found for the autistic candidates. Conclusions Results indicate that observers may use different information when evaluating autistic compared with non-autistic interviewees, possibly due to qualitative differences in behavior. Implications of different behavioral presentations in autistic candidates are discussed, including the potential benefits of using transcripts or more structured interviews to enable recruiters to focus on interviewee answers, whilst being less influenced by non-verbal and para-verbal behaviors. En ligne : https://doi.org/10.1016/j.rasd.2024.102333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Perceptions of autistic and non-autistic adults in employment interviews: The role of impression management [Texte imprimé et/ou numérique] / Jade Eloise NORRIS, Auteur ; Jemma NICHOLSON, Auteur ; Rachel PROSSER, Auteur ; Jessica FARRELL, Auteur ; Anna REMINGTON, Auteur ; Laura CRANE, Auteur ; Laura HULL, Auteur ; Katie MARAS, Auteur . - p.102333. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102333 Mots-clés : Autism  Employment  Interviews  Impression management  Non-verbal  Behavioral Index. décimale : PER Périodiques Résumé : Background Social communication and interaction differences can make employment interviews particularly challenging for autistic people, who may be less able to modulate their Impression Management (IM). This makes autism a relevant test case of the extent to which behavioral IM influences perceptions of job candidates. Method Two studies are reported. In Study 1, lay-raters watched a video of autistic and non-autistic mock candidates' interviews, and assessed their verbal, non-verbal, and para-verbal behaviors, and likelihood of social approach/avoidance. In Study 2, the presence of behavioral cues was manipulated by using either the interview videos (behavioral cues present) or transcripts (cues absent). Employers rated their overall impression of the candidates (e.g., perceived confidence, conscientiousness, competence, communication skills, etc). Results In study 1, autistic candidates were perceived as having a more monotonous tone of voice, being less composed and focused, and displaying less natural eye contact and gestures than their non-autistic counterparts, and received lower ratings for likelihood of social approach. For non-autistic interviewees, relationships were also found between ratings for verbal, para-verbal, and non-verbal behaviors, and social awkwardness and attractiveness. In study 2, non-autistic (but not autistic) interviewees received higher ratings of their confidence and communication skills when assessed by video than by transcript, but this advantage was not found for the autistic candidates. Conclusions Results indicate that observers may use different information when evaluating autistic compared with non-autistic interviewees, possibly due to qualitative differences in behavior. Implications of different behavioral presentations in autistic candidates are discussed, including the potential benefits of using transcripts or more structured interviews to enable recruiters to focus on interviewee answers, whilst being less influenced by non-verbal and para-verbal behaviors. En ligne : https://doi.org/10.1016/j.rasd.2024.102333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

The relationship between alexithymia and self-esteem in autistic adolescents / Melissa STRANG in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102334 Titre : The relationship between alexithymia and self-esteem in autistic adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Melissa STRANG, Auteur ; Caitlin M. MACMILLAN, Auteur ; Claire M. BROWN, Auteur ; Merrilyn HOOLEY, Auteur ; Mark A. STOKES, Auteur Article en page(s) : p.102334 Langues : Anglais (eng) Mots-clés : Autism  Self-esteem  Cognitive Alexithymia  Affective Alexithymia  Adolescence Index. décimale : PER Périodiques Résumé : Background Research suggests autistic adolescents experience lower self-esteem and higher cognitive alexithymia than non-autistic adolescents. Heightened cognitive alexithymia has been associated with lower self-esteem in non-autistic adolescents but remains unexamined in autistic populations. This study aimed to examine whether autism diagnosis and alexithymia subscales significantly predicted self-esteem. Method Data were collected from 102 participants (53 autistic and 49 non-autistic adolescents) using the Rosenberg Self-Esteem Scale, Bermond-Vorst Alexithymia Questionnaire, and the Autism Quotient. Results Our results found that compared to non-autistic adolescents, autistic adolescents report lower self-esteem (F(1, 99)= 8.79, p < .005, ?2= .08), and higher cognitive alexithymia (F(1, 99)= 22.51, p < .001, ?2= .19), but not affective alexithymia (F(1, 99)= .50, p = .481, ?2< .01). Additionally, we found evidence that autism diagnosis (b=?2.86, SE=0.99, p = .005) and cognitive alexithymia (b=?0.30, SE=0.10, p = .003), but not affective alexithymia, predicted lower self-esteem. The addition of cognitive alexithymia to the model removed the significance of diagnosis (b=?1.31, SE=1.02, p = .201). This model accounted for 26% of variance (R2=.26, F(7, 94)= 4.77, p < .001). Exploratory mediation analysis revealed that cognitive alexithymia significantly mediated the relationship between autistic traits and self-esteem (b=?0.10, SE=0.03, CI[?0.16, ?0.49], p < .001), accounting for 22.93% of variance, and removing any direct effect. Conclusion The results suggest that autistic adolescents experiencing difficulties identifying emotions are more likely to have lower self-esteem than autistic adolescents that report less difficulty identifying emotions. Assessing autistic adolescents for alexithymia and providing support to identify emotions may result in more effective support for low self-esteem. En ligne : https://doi.org/10.1016/j.rasd.2024.102334 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] The relationship between alexithymia and self-esteem in autistic adolescents [Texte imprimé et/ou numérique] / Melissa STRANG, Auteur ; Caitlin M. MACMILLAN, Auteur ; Claire M. BROWN, Auteur ; Merrilyn HOOLEY, Auteur ; Mark A. STOKES, Auteur . - p.102334. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102334 Mots-clés : Autism  Self-esteem  Cognitive Alexithymia  Affective Alexithymia  Adolescence Index. décimale : PER Périodiques Résumé : Background Research suggests autistic adolescents experience lower self-esteem and higher cognitive alexithymia than non-autistic adolescents. Heightened cognitive alexithymia has been associated with lower self-esteem in non-autistic adolescents but remains unexamined in autistic populations. This study aimed to examine whether autism diagnosis and alexithymia subscales significantly predicted self-esteem. Method Data were collected from 102 participants (53 autistic and 49 non-autistic adolescents) using the Rosenberg Self-Esteem Scale, Bermond-Vorst Alexithymia Questionnaire, and the Autism Quotient. Results Our results found that compared to non-autistic adolescents, autistic adolescents report lower self-esteem (F(1, 99)= 8.79, p < .005, ?2= .08), and higher cognitive alexithymia (F(1, 99)= 22.51, p < .001, ?2= .19), but not affective alexithymia (F(1, 99)= .50, p = .481, ?2< .01). Additionally, we found evidence that autism diagnosis (b=?2.86, SE=0.99, p = .005) and cognitive alexithymia (b=?0.30, SE=0.10, p = .003), but not affective alexithymia, predicted lower self-esteem. The addition of cognitive alexithymia to the model removed the significance of diagnosis (b=?1.31, SE=1.02, p = .201). This model accounted for 26% of variance (R2=.26, F(7, 94)= 4.77, p < .001). Exploratory mediation analysis revealed that cognitive alexithymia significantly mediated the relationship between autistic traits and self-esteem (b=?0.10, SE=0.03, CI[?0.16, ?0.49], p < .001), accounting for 22.93% of variance, and removing any direct effect. Conclusion The results suggest that autistic adolescents experiencing difficulties identifying emotions are more likely to have lower self-esteem than autistic adolescents that report less difficulty identifying emotions. Assessing autistic adolescents for alexithymia and providing support to identify emotions may result in more effective support for low self-esteem. En ligne : https://doi.org/10.1016/j.rasd.2024.102334 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

A replication and extension of the Cool Kids Autism Spectrum Disorder Anxiety Program: Randomised controlled trial reducing anxiety in autistic adolescents / Theresa M. KIDD in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102335 Titre : A replication and extension of the Cool Kids Autism Spectrum Disorder Anxiety Program: Randomised controlled trial reducing anxiety in autistic adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Theresa M. KIDD, Auteur ; Rosanna M. ROONEY, Auteur ; Trevor G. MAZZUCCHELLI, Auteur ; Kate E. TONTA, Auteur ; Jacob D. PECKOVER, Auteur ; Robert T. KANE, Auteur Article en page(s) : p.102335 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Anxiety  Cognitive behavioural therapy  Adolescents Index. décimale : PER Périodiques Résumé : Background Autistic adolescents who experience anxiety face unique challenges. Cognitive-behavioural therapy is an evidence-based treatment for anxiety in Autistic children, yet there is less evidence for adaptations of these CBT group interventions for adolescent populations. Method This study evaluated the efficacy of the Cool Kids Autism Spectrum Disorder Anxiety program in reducing anxiety in Autistic adolescents. Forty-nine Autistic adolescents with clinically significant anxiety (ages 12-18; IQ > 70) were randomly assigned to the intervention condition or waitlist. Results There were reductions in anxiety severity for the intervention group compared to waitlist, in diagnostic status, clinical severity, and parent ratings. Post-treatment, 72% of participants in the intervention group showed remission of their primary anxiety disorder diagnosis compared to 31.6% of the waitlist. Conclusions The Cool Kids ASD Anxiety Program may be effective for reducing clinical anxiety in Autistic adolescents, and future studies should replicate these findings with additional consideration of the role of parents in treatment outcomes. En ligne : https://doi.org/10.1016/j.rasd.2024.102335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] A replication and extension of the Cool Kids Autism Spectrum Disorder Anxiety Program: Randomised controlled trial reducing anxiety in autistic adolescents [Texte imprimé et/ou numérique] / Theresa M. KIDD, Auteur ; Rosanna M. ROONEY, Auteur ; Trevor G. MAZZUCCHELLI, Auteur ; Kate E. TONTA, Auteur ; Jacob D. PECKOVER, Auteur ; Robert T. KANE, Auteur . - p.102335. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102335 Mots-clés : Autism spectrum disorder  Anxiety  Cognitive behavioural therapy  Adolescents Index. décimale : PER Périodiques Résumé : Background Autistic adolescents who experience anxiety face unique challenges. Cognitive-behavioural therapy is an evidence-based treatment for anxiety in Autistic children, yet there is less evidence for adaptations of these CBT group interventions for adolescent populations. Method This study evaluated the efficacy of the Cool Kids Autism Spectrum Disorder Anxiety program in reducing anxiety in Autistic adolescents. Forty-nine Autistic adolescents with clinically significant anxiety (ages 12-18; IQ > 70) were randomly assigned to the intervention condition or waitlist. Results There were reductions in anxiety severity for the intervention group compared to waitlist, in diagnostic status, clinical severity, and parent ratings. Post-treatment, 72% of participants in the intervention group showed remission of their primary anxiety disorder diagnosis compared to 31.6% of the waitlist. Conclusions The Cool Kids ASD Anxiety Program may be effective for reducing clinical anxiety in Autistic adolescents, and future studies should replicate these findings with additional consideration of the role of parents in treatment outcomes. En ligne : https://doi.org/10.1016/j.rasd.2024.102335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Impact of child-centered play therapy intervention on children with autism reflected by brain EEG activity: A randomized controlled trial / Kim-Lui Raise CHAN in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102336 Titre : Impact of child-centered play therapy intervention on children with autism reflected by brain EEG activity: A randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Kim-Lui Raise CHAN, Auteur ; Guang OUYANG, Auteur Article en page(s) : p.102336 Langues : Anglais (eng) Mots-clés : Child-centered play therapy  Autistic children  EEG  Alpha power  Randomized controlled trial Index. décimale : PER Périodiques Résumé : Objective Research into the effects of child-centered play therapy (CCPT) consistently highlights its positive impact on autistic children. However, its effectiveness at the neural level is underexplored. To address this research gap, the present study investigates the influence of CCPT interventions on autistic children, specifically focusing on measurable changes in brain activity through electroencephalography (EEG) alpha power analysis. Methods Autistic children were randomly assigned to an experimental group (EXP; n = 34; Mage = 7.50) and a waitlist group (WL; n = 31; Mage = 7.47). The EXP group underwent weekly 45-minute individual CCPT sessions for 8 weeks. Pre- and post-intervention EEG recordings during a social activity with varied social contexts were obtained. In addition, behavioral data from the Social Responsiveness Scale-2 (SRS-2), Autism Spectrum Quotient-Child (AQ-child; social skills subscale), and Adaptive Behavior Assessment System-II (ABAS-II; social domain) were collected before and after the intervention. Results Linear mixed models revealed a significant increase in alpha amplitude post-intervention across all social activities and conditions in the EXP group. Notably, significant differences in SRS-2, AQ-child (social skills), and ABAS-II (social domain) scores were observed between pre- and post-CCPT intervention in the EXP group. In contrast, impacts on both neural and behavioral activity remained nonsignificant in the WL group. Conclusion CCPT exhibits a significant positive effect on autistic children, as evidenced by changes in EEG alpha power and improvements in SRS-2, AQ-child (social skills), and ABAS-II (social domain) scores. These results provide data for future investigation of the intricate neural mechanisms underlying the CCPT-enhanced social behavior observed in autistic children. En ligne : https://doi.org/10.1016/j.rasd.2024.102336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Impact of child-centered play therapy intervention on children with autism reflected by brain EEG activity: A randomized controlled trial [Texte imprimé et/ou numérique] / Kim-Lui Raise CHAN, Auteur ; Guang OUYANG, Auteur . - p.102336. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102336 Mots-clés : Child-centered play therapy  Autistic children  EEG  Alpha power  Randomized controlled trial Index. décimale : PER Périodiques Résumé : Objective Research into the effects of child-centered play therapy (CCPT) consistently highlights its positive impact on autistic children. However, its effectiveness at the neural level is underexplored. To address this research gap, the present study investigates the influence of CCPT interventions on autistic children, specifically focusing on measurable changes in brain activity through electroencephalography (EEG) alpha power analysis. Methods Autistic children were randomly assigned to an experimental group (EXP; n = 34; Mage = 7.50) and a waitlist group (WL; n = 31; Mage = 7.47). The EXP group underwent weekly 45-minute individual CCPT sessions for 8 weeks. Pre- and post-intervention EEG recordings during a social activity with varied social contexts were obtained. In addition, behavioral data from the Social Responsiveness Scale-2 (SRS-2), Autism Spectrum Quotient-Child (AQ-child; social skills subscale), and Adaptive Behavior Assessment System-II (ABAS-II; social domain) were collected before and after the intervention. Results Linear mixed models revealed a significant increase in alpha amplitude post-intervention across all social activities and conditions in the EXP group. Notably, significant differences in SRS-2, AQ-child (social skills), and ABAS-II (social domain) scores were observed between pre- and post-CCPT intervention in the EXP group. In contrast, impacts on both neural and behavioral activity remained nonsignificant in the WL group. Conclusion CCPT exhibits a significant positive effect on autistic children, as evidenced by changes in EEG alpha power and improvements in SRS-2, AQ-child (social skills), and ABAS-II (social domain) scores. These results provide data for future investigation of the intricate neural mechanisms underlying the CCPT-enhanced social behavior observed in autistic children. En ligne : https://doi.org/10.1016/j.rasd.2024.102336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

The impact of parenting stress and cultural orientation on communication skills in minimally verbal children with autism spectrum disorders: A comparative study in India and the US / Suma SUSWARAM in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102337 Titre : The impact of parenting stress and cultural orientation on communication skills in minimally verbal children with autism spectrum disorders: A comparative study in India and the US Type de document : Texte imprimé et/ou numérique Auteurs : Suma SUSWARAM, Auteur ; Nancy C. BRADY, Auteur ; Brian BOYD, Auteur Article en page(s) : p.102337 Langues : Anglais (eng) Mots-clés : Minimal verbal  Autism Spectrum Disorders (ASD)  Communication skills  Parenting stress  Culture  Parent-reported Index. décimale : PER Périodiques Résumé : Background Assessing the impact of intrinsic and extrinsic factors on communication skill development in minimally verbal children with Autism Spectrum Disorders (MV-ASD) is crucial, yet limited research exists on cultural variations of these factors. This study explored the associations between parenting stress, cultural orientation, and communication skills in children with MV-ASD from India and the US. Methods Data were collected through parent-report questionnaires and standardized assessments. Participants included parents of children with MV-ASD from India and the US. The study examined the relationship between parenting stress, cultural orientation, and communication skills in these cultural communities. Results Parenting stress exhibited a negative association with communication skills in both the Indian and US groups of children with MV-ASD. Cultural orientation was identified as a moderator in the relationship when child?s communication skills predicted variability in parenting stress. Conclusions This study emphasizes the influence of parenting stress and cultural orientation on the development of communication skills in children with MV-ASD across cultural communities. Understanding these factors can aid in addressing the unique challenges faced by these children and inform culturally sensitive interventions. En ligne : https://doi.org/10.1016/j.rasd.2024.102337 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] The impact of parenting stress and cultural orientation on communication skills in minimally verbal children with autism spectrum disorders: A comparative study in India and the US [Texte imprimé et/ou numérique] / Suma SUSWARAM, Auteur ; Nancy C. BRADY, Auteur ; Brian BOYD, Auteur . - p.102337. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102337 Mots-clés : Minimal verbal  Autism Spectrum Disorders (ASD)  Communication skills  Parenting stress  Culture  Parent-reported Index. décimale : PER Périodiques Résumé : Background Assessing the impact of intrinsic and extrinsic factors on communication skill development in minimally verbal children with Autism Spectrum Disorders (MV-ASD) is crucial, yet limited research exists on cultural variations of these factors. This study explored the associations between parenting stress, cultural orientation, and communication skills in children with MV-ASD from India and the US. Methods Data were collected through parent-report questionnaires and standardized assessments. Participants included parents of children with MV-ASD from India and the US. The study examined the relationship between parenting stress, cultural orientation, and communication skills in these cultural communities. Results Parenting stress exhibited a negative association with communication skills in both the Indian and US groups of children with MV-ASD. Cultural orientation was identified as a moderator in the relationship when child?s communication skills predicted variability in parenting stress. Conclusions This study emphasizes the influence of parenting stress and cultural orientation on the development of communication skills in children with MV-ASD across cultural communities. Understanding these factors can aid in addressing the unique challenges faced by these children and inform culturally sensitive interventions. En ligne : https://doi.org/10.1016/j.rasd.2024.102337 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

"I?m not mad, bad, and dangerous ? simply wired differently": Exploring factors contributing to good quality of life with autistic women / Arianna PARICOS in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102338 Titre : "I?m not mad, bad, and dangerous ? simply wired differently": Exploring factors contributing to good quality of life with autistic women Type de document : Texte imprimé et/ou numérique Auteurs : Arianna PARICOS, Auteur ; Alexandra STURROCK, Auteur ; Katherine TWOMEY, Auteur ; Kathy LEADBITTER, Auteur Article en page(s) : p.102338 Langues : Anglais (eng) Mots-clés : Autism  Quality of life  Qualitative  Women  Neurodiversity Index. décimale : PER Périodiques Résumé : Background There is increasing recognition of under-representation of autistic women in the academic literature and the impact of this on understanding, diagnosis, and support. Previous research has suggested that autistic women have poorer quality of life (QoL) than the general population. However, these findings have been established through use of QoL measures based on non-autistic norms and priorities. Methods This qualitative study used bottom-up, reflexive thematic analysis methods to explore how ten autistic women defined good QoL, and the factors identified as key to achieving this, using individual semi-structured interviews. Results Findings indicate four main themes that represent routes to good QoL: positive sense of self; feeling supported; autonomy; inclusion. Participants noted that being autistic itself was not a determinant of reduced QoL. Instead, participants' QoL was underpinned by the extent to which participants understood themselves, others understood and accommodated their needs, and the person-environment fit. Conclusions The findings of this study align with a positive approach to neurological difference and have implications for diagnosis, post-diagnostic support and applications of current QoL measures for autistic women. En ligne : https://doi.org/10.1016/j.rasd.2024.102338 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] "I?m not mad, bad, and dangerous ? simply wired differently": Exploring factors contributing to good quality of life with autistic women [Texte imprimé et/ou numérique] / Arianna PARICOS, Auteur ; Alexandra STURROCK, Auteur ; Katherine TWOMEY, Auteur ; Kathy LEADBITTER, Auteur . - p.102338. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102338 Mots-clés : Autism  Quality of life  Qualitative  Women  Neurodiversity Index. décimale : PER Périodiques Résumé : Background There is increasing recognition of under-representation of autistic women in the academic literature and the impact of this on understanding, diagnosis, and support. Previous research has suggested that autistic women have poorer quality of life (QoL) than the general population. However, these findings have been established through use of QoL measures based on non-autistic norms and priorities. Methods This qualitative study used bottom-up, reflexive thematic analysis methods to explore how ten autistic women defined good QoL, and the factors identified as key to achieving this, using individual semi-structured interviews. Results Findings indicate four main themes that represent routes to good QoL: positive sense of self; feeling supported; autonomy; inclusion. Participants noted that being autistic itself was not a determinant of reduced QoL. Instead, participants' QoL was underpinned by the extent to which participants understood themselves, others understood and accommodated their needs, and the person-environment fit. Conclusions The findings of this study align with a positive approach to neurological difference and have implications for diagnosis, post-diagnostic support and applications of current QoL measures for autistic women. En ligne : https://doi.org/10.1016/j.rasd.2024.102338 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Autistic traits in adolescents in psychiatric inpatient care: Clinical and demographic characteristics and correlates / Jessica M. SCHWARTZMAN in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102339 Titre : Autistic traits in adolescents in psychiatric inpatient care: Clinical and demographic characteristics and correlates Type de document : Texte imprimé et/ou numérique Auteurs : Jessica M. SCHWARTZMAN, Auteur ; Alexandra H. BETTIS, Auteur Article en page(s) : p.102339 Langues : Anglais (eng) Mots-clés : Autistic traits  Adolescent  Hospitalization  Suicidal ideation  Psychiatric inpatient unit Index. décimale : PER Périodiques Résumé : Background Rates of psychiatric hospitalization among adolescents in the United States are rising, with many adolescents presenting to these settings with diverse clinical presentations, including autistic traits. To our knowledge, there has been little research identifying clinical characteristics of adolescents with autistic traits admitted to psychiatric inpatient units, which may be leveraged to improve assessment and treatment practices. Method In the current study, we examined clinical and demographic characteristics of 195 adolescents admitted to an adolescent psychiatric inpatient unit. Specifically, we investigated the prevalence of adolescents endorsing elevated autistic traits and tested associations between autistic traits, psychiatric symptoms (anxiety, depression, suicidal thoughts), and key demographic variables (age, sex, gender, sexual orientation). Results Results show that over half of the adolescents admitted to the psychiatric inpatient unit reported elevated autistic traits on a short screening questionnaire. Higher autistic traits were significantly associated with more severe depressive symptoms, though to a small degree. Autistic traits were not associated with anxiety symptoms, suicidal thoughts, nor social disconnectedness, and did not differ by sex, gender identity, nor sexual orientation. Conclusions Findings highlight the challenge of diagnostic overshadowing among adolescents in crisis and the need for more rigorous measures designed for an inpatient setting to improve risk stratification, clinical assessments, intervention approaches, and discharge planning. En ligne : https://doi.org/10.1016/j.rasd.2024.102339 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Autistic traits in adolescents in psychiatric inpatient care: Clinical and demographic characteristics and correlates [Texte imprimé et/ou numérique] / Jessica M. SCHWARTZMAN, Auteur ; Alexandra H. BETTIS, Auteur . - p.102339. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102339 Mots-clés : Autistic traits  Adolescent  Hospitalization  Suicidal ideation  Psychiatric inpatient unit Index. décimale : PER Périodiques Résumé : Background Rates of psychiatric hospitalization among adolescents in the United States are rising, with many adolescents presenting to these settings with diverse clinical presentations, including autistic traits. To our knowledge, there has been little research identifying clinical characteristics of adolescents with autistic traits admitted to psychiatric inpatient units, which may be leveraged to improve assessment and treatment practices. Method In the current study, we examined clinical and demographic characteristics of 195 adolescents admitted to an adolescent psychiatric inpatient unit. Specifically, we investigated the prevalence of adolescents endorsing elevated autistic traits and tested associations between autistic traits, psychiatric symptoms (anxiety, depression, suicidal thoughts), and key demographic variables (age, sex, gender, sexual orientation). Results Results show that over half of the adolescents admitted to the psychiatric inpatient unit reported elevated autistic traits on a short screening questionnaire. Higher autistic traits were significantly associated with more severe depressive symptoms, though to a small degree. Autistic traits were not associated with anxiety symptoms, suicidal thoughts, nor social disconnectedness, and did not differ by sex, gender identity, nor sexual orientation. Conclusions Findings highlight the challenge of diagnostic overshadowing among adolescents in crisis and the need for more rigorous measures designed for an inpatient setting to improve risk stratification, clinical assessments, intervention approaches, and discharge planning. En ligne : https://doi.org/10.1016/j.rasd.2024.102339 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Spatial and identity cues differentially affect implicit learning in Chinese autistic children in the contextual cueing task with human stimuli / Yu XIE in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102349 Titre : Spatial and identity cues differentially affect implicit learning in Chinese autistic children in the contextual cueing task with human stimuli Type de document : Texte imprimé et/ou numérique Auteurs : Yu XIE, Auteur ; Hui-Zhong HE, Auteur ; Linda R. WATSON, Auteur ; Zhi-Han DONG, Auteur Article en page(s) : p.102349 Langues : Anglais (eng) Mots-clés : Autism  Children  Implicit learning  Identity cues  Spatial cues  Visual attention Index. décimale : PER Périodiques Résumé : Background Autistic children cannot adjust their behaviors in response to environmental social cues as readily as typically developing children. The development of adaptive social behaviors is mainly dependent on the ability to implicitly learn associations or probabilities that are embedded in the environmental cues. Mounting evidence has suggested that autistic individuals have intact implicit learning in contextual cueing (CC) tasks with simple arrays of letters or numbers. However, it remains unclear whether autistic individuals have intact implicit learning in CC tasks with human stimuli. Spatial cues and stimulus-identity cues in CC tasks are thought to rely on distinct neural networks. It is also unknown whether these different types of cues will have different effects on implicit learning in autistic children if human photographs are used in CC tasks. This study examined the implicit learning performance of autistic children under different cue conditions in CC tasks that used photographs of children. Results Autistic children showed similar implicit learning performance to the comparison group, using only stimulus-identity cues. When both stimulus-identity and spatial cues were provided, implicit contextual learning was only observed in the comparison children, but not in the autistic group. Conclusions The results suggest that spatial cues and stimulus-identity cues have different effects on the implicit learning performance of autistic children. The atypical performance of autistic children on implicit learning when spatial cues combined with identity cues may result in divergent social behaviors and serve as an intrinsic mechanistic contributor to social interaction differences associated with autism. En ligne : https://doi.org/10.1016/j.rasd.2024.102349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Spatial and identity cues differentially affect implicit learning in Chinese autistic children in the contextual cueing task with human stimuli [Texte imprimé et/ou numérique] / Yu XIE, Auteur ; Hui-Zhong HE, Auteur ; Linda R. WATSON, Auteur ; Zhi-Han DONG, Auteur . - p.102349. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102349 Mots-clés : Autism  Children  Implicit learning  Identity cues  Spatial cues  Visual attention Index. décimale : PER Périodiques Résumé : Background Autistic children cannot adjust their behaviors in response to environmental social cues as readily as typically developing children. The development of adaptive social behaviors is mainly dependent on the ability to implicitly learn associations or probabilities that are embedded in the environmental cues. Mounting evidence has suggested that autistic individuals have intact implicit learning in contextual cueing (CC) tasks with simple arrays of letters or numbers. However, it remains unclear whether autistic individuals have intact implicit learning in CC tasks with human stimuli. Spatial cues and stimulus-identity cues in CC tasks are thought to rely on distinct neural networks. It is also unknown whether these different types of cues will have different effects on implicit learning in autistic children if human photographs are used in CC tasks. This study examined the implicit learning performance of autistic children under different cue conditions in CC tasks that used photographs of children. Results Autistic children showed similar implicit learning performance to the comparison group, using only stimulus-identity cues. When both stimulus-identity and spatial cues were provided, implicit contextual learning was only observed in the comparison children, but not in the autistic group. Conclusions The results suggest that spatial cues and stimulus-identity cues have different effects on the implicit learning performance of autistic children. The atypical performance of autistic children on implicit learning when spatial cues combined with identity cues may result in divergent social behaviors and serve as an intrinsic mechanistic contributor to social interaction differences associated with autism. En ligne : https://doi.org/10.1016/j.rasd.2024.102349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials / Ruzha PANCHEVA in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102352 Titre : Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Ruzha PANCHEVA, Auteur ; Rositsa CHAMOVA, Auteur ; Dimitar MARINOV, Auteur ; Albena TONEVA, Auteur ; Mariya DZHOGOVA, Auteur ; Sevdzhihan EYUBOVA, Auteur ; Natalya USHEVA, Auteur Article en page(s) : p.102352 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Nutritional interventions  Clinical trials  Gluten-free diet  Omega-3 fatty acids  Vitamins  Probiotics  Developmental disabilities Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits, restricted interests, and repetitive behaviors. Nutritional interventions have gained attention as potential therapeutic strategies for individuals with ASD. This review aims to provide a comprehensive summary of recent clinical trials investigating the effects of various nutritional interventions on ASD symptoms. Methods A systematic search was conducted in multiple databases to identify clinical trials published between 2018 and 2023. Studies focusing on children with ASD and evaluating the impact of nutritional interventions were included. The selected articles were analyzed for study design, intervention type, outcome measures, and results. Results A total of 26 studies were included in the review, covering a range of nutritional interventions including gluten-free and casein-free diets, omega-3 fatty acid supplementation, vitamin and mineral supplementation, probiotics, prebiotics, and others. The studies varied in design, sample size, and outcome measures. Overall, the findings revealed some positive effects of specific nutritional interventions on ASD symptoms, such as improvements in social responsiveness, communication, hyperactivity, and stereotypical behaviors. However, discrepancies and limitations were noted across the studies, highlighting the need for further research. Conclusion This comprehensive review provides insights into the potential therapeutic effects of nutritional interventions for individuals with ASD. While some interventions showed promising results, further research with larger sample sizes, standardized methodologies, and longer-term follow-ups is needed to establish their efficacy. Personalized approaches, considering the heterogeneity of ASD, and strategies to enhance adherence to dietary interventions are also crucial in developing effective treatment plans. Overall, nutritional interventions hold promise as adjunctive therapies for individuals with ASD, warranting continued investigation in this field of research. En ligne : https://doi.org/10.1016/j.rasd.2024.102352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials [Texte imprimé et/ou numérique] / Ruzha PANCHEVA, Auteur ; Rositsa CHAMOVA, Auteur ; Dimitar MARINOV, Auteur ; Albena TONEVA, Auteur ; Mariya DZHOGOVA, Auteur ; Sevdzhihan EYUBOVA, Auteur ; Natalya USHEVA, Auteur . - p.102352. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102352 Mots-clés : Autism Spectrum Disorder  Nutritional interventions  Clinical trials  Gluten-free diet  Omega-3 fatty acids  Vitamins  Probiotics  Developmental disabilities Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits, restricted interests, and repetitive behaviors. Nutritional interventions have gained attention as potential therapeutic strategies for individuals with ASD. This review aims to provide a comprehensive summary of recent clinical trials investigating the effects of various nutritional interventions on ASD symptoms. Methods A systematic search was conducted in multiple databases to identify clinical trials published between 2018 and 2023. Studies focusing on children with ASD and evaluating the impact of nutritional interventions were included. The selected articles were analyzed for study design, intervention type, outcome measures, and results. Results A total of 26 studies were included in the review, covering a range of nutritional interventions including gluten-free and casein-free diets, omega-3 fatty acid supplementation, vitamin and mineral supplementation, probiotics, prebiotics, and others. The studies varied in design, sample size, and outcome measures. Overall, the findings revealed some positive effects of specific nutritional interventions on ASD symptoms, such as improvements in social responsiveness, communication, hyperactivity, and stereotypical behaviors. However, discrepancies and limitations were noted across the studies, highlighting the need for further research. Conclusion This comprehensive review provides insights into the potential therapeutic effects of nutritional interventions for individuals with ASD. While some interventions showed promising results, further research with larger sample sizes, standardized methodologies, and longer-term follow-ups is needed to establish their efficacy. Personalized approaches, considering the heterogeneity of ASD, and strategies to enhance adherence to dietary interventions are also crucial in developing effective treatment plans. Overall, nutritional interventions hold promise as adjunctive therapies for individuals with ASD, warranting continued investigation in this field of research. En ligne : https://doi.org/10.1016/j.rasd.2024.102352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Inhibition of purinergic P2 receptors prevents synaptic and behavioral alterations in a rodent model of autism spectrum disorders / Lidia BABIEC in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102353 Titre : Inhibition of purinergic P2 receptors prevents synaptic and behavioral alterations in a rodent model of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lidia BABIEC, Auteur ; Anna WILKANIEC, Auteur ; El?bieta GAWINEK, Auteur ; Wojciech HILGIER, Auteur ; Agata ADAMCZYK, Auteur Article en page(s) : p.102353 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Valproic acid  Extracellular nucleotides  Purinergic receptors  IsoPPADS  PPADS Index. décimale : PER Périodiques Résumé : Background Extracellular nucleotides acting through specific purinergic receptors play a key role in synaptic transmission and neuromodulation. Therefore, any deregulation of purine-dependent signaling may lead to synaptic dysfunction and the development of autism-like behaviors. Method Here, we used a well-established autism spectrum disorders (ASD) model of a single prenatal exposure to valproic acid (VPA). Wistar female rats received an i.p. injection of VPA (450 mg/kg body weight) at gestational day 12.5. To study the involvement of purinergic signaling in the alterations of the key synaptic proteins and the development of ASD-like behaviors in VPA offspring at 52. post-natal day, we performed a single i.p. injection of the non-selective P2-purinoceptor antagonists PPADS and isoPPADS (12.5 mg/kg body weight) 24 h before behavioral tests. Results The results showed an increased level of ATP and its metabolites, ADP, and AMP in the cerebrospinal fluid of VPA offspring indicating significant dysregulation in extracellular nucleotides- signaling, that may result in synaptic aberrations. Treatment with isoPPADS significantly prevented alterations of the selected synaptic proteins evoked by prenatal VPA exposure along with prevention of the overactivation of mTOR kinase, while both purinergic antagonists reversed autism-like behavior. This suggests that apart from the activation of the mTOR signaling cascade, purinergic deregulation may influence molecular pathways other than synaptic protein imbalance. Conclusions Disturbances in the ATP turnover and overstimulation of purinergic receptors are responsible for synaptic proteins' dyshomeostasis and the appearance of ASD-like behaviors. mTOR kinase might be partially responsible for the development of autistic symptoms evoked by hyperpurinergia. En ligne : https://doi.org/10.1016/j.rasd.2024.102353 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Inhibition of purinergic P2 receptors prevents synaptic and behavioral alterations in a rodent model of autism spectrum disorders [Texte imprimé et/ou numérique] / Lidia BABIEC, Auteur ; Anna WILKANIEC, Auteur ; El?bieta GAWINEK, Auteur ; Wojciech HILGIER, Auteur ; Agata ADAMCZYK, Auteur . - p.102353. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102353 Mots-clés : Autism spectrum disorders  Valproic acid  Extracellular nucleotides  Purinergic receptors  IsoPPADS  PPADS Index. décimale : PER Périodiques Résumé : Background Extracellular nucleotides acting through specific purinergic receptors play a key role in synaptic transmission and neuromodulation. Therefore, any deregulation of purine-dependent signaling may lead to synaptic dysfunction and the development of autism-like behaviors. Method Here, we used a well-established autism spectrum disorders (ASD) model of a single prenatal exposure to valproic acid (VPA). Wistar female rats received an i.p. injection of VPA (450 mg/kg body weight) at gestational day 12.5. To study the involvement of purinergic signaling in the alterations of the key synaptic proteins and the development of ASD-like behaviors in VPA offspring at 52. post-natal day, we performed a single i.p. injection of the non-selective P2-purinoceptor antagonists PPADS and isoPPADS (12.5 mg/kg body weight) 24 h before behavioral tests. Results The results showed an increased level of ATP and its metabolites, ADP, and AMP in the cerebrospinal fluid of VPA offspring indicating significant dysregulation in extracellular nucleotides- signaling, that may result in synaptic aberrations. Treatment with isoPPADS significantly prevented alterations of the selected synaptic proteins evoked by prenatal VPA exposure along with prevention of the overactivation of mTOR kinase, while both purinergic antagonists reversed autism-like behavior. This suggests that apart from the activation of the mTOR signaling cascade, purinergic deregulation may influence molecular pathways other than synaptic protein imbalance. Conclusions Disturbances in the ATP turnover and overstimulation of purinergic receptors are responsible for synaptic proteins' dyshomeostasis and the appearance of ASD-like behaviors. mTOR kinase might be partially responsible for the development of autistic symptoms evoked by hyperpurinergia. En ligne : https://doi.org/10.1016/j.rasd.2024.102353 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Social context in stress and autism: comparing physiological profiles across two social paradigms in youth with and without autism spectrum disorder / Rachael A. MUSCATELLO in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102354 Titre : Social context in stress and autism: comparing physiological profiles across two social paradigms in youth with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Trey MCGONIGLE, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.102354 Langues : Anglais (eng) Mots-clés : Autism  Heart rate  Cortisol  Social  Stress  Interaction Index. décimale : PER Périodiques Résumé : Background The social world is often stressful for individuals with autism spectrum disorder (ASD). Research shows youth with ASD demonstrate physiological hyperreactivity to some social stressors (e.g., interaction) but not others (e.g., evaluation); therefore, this study examined diagnosis (ASD or typical development (TD)), social context, perceived anxiety, and physiological responsivity across multiple stress systems; namely, the hypothalamic pituitary adrenal (HPA) axis and autonomic nervous system (ANS). Method This study examined 244 ten-to-thirteen-year-olds with ASD (N = 140) or TD (N = 104). Physiological responses, measured by salivary cortisol, heart rate (HR), and respiratory sinus arrhythmia (RSA), were assessed before and after a social evaluative threat paradigm (Trier Social Stress Test; TSST) and social interaction (Trier Social Stress Test- Friendly; TSST-F). Mediation models examined the relationships between anxiety, diagnosis, and physiology. Results Significant three-way interactions were observed for cortisol (p = 0.007) and HR (p = 0.002), suggesting diagnostic groups respond differently across context and time points. There was no significant interaction for RSA (p = 0.149), although ASD youth had significantly lower RSA overall (p = 0.038). State and trait anxiety did not mediate the relationship between diagnosis and physiology (all p > 0.05). Conclusions Findings emphasize the critical role of context and a multisystem approach in examination of physiological social stress in youth with ASD. Results provide a foundation to elucidate unique response patterns across physiological systems to more precisely identify those with heightened physiological arousal across social contexts. It is proposed that future identification of subtypes may ultimately inform approaches for enhancing social engagement. En ligne : https://doi.org/10.1016/j.rasd.2024.102354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Social context in stress and autism: comparing physiological profiles across two social paradigms in youth with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Trey MCGONIGLE, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur . - p.102354. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102354 Mots-clés : Autism  Heart rate  Cortisol  Social  Stress  Interaction Index. décimale : PER Périodiques Résumé : Background The social world is often stressful for individuals with autism spectrum disorder (ASD). Research shows youth with ASD demonstrate physiological hyperreactivity to some social stressors (e.g., interaction) but not others (e.g., evaluation); therefore, this study examined diagnosis (ASD or typical development (TD)), social context, perceived anxiety, and physiological responsivity across multiple stress systems; namely, the hypothalamic pituitary adrenal (HPA) axis and autonomic nervous system (ANS). Method This study examined 244 ten-to-thirteen-year-olds with ASD (N = 140) or TD (N = 104). Physiological responses, measured by salivary cortisol, heart rate (HR), and respiratory sinus arrhythmia (RSA), were assessed before and after a social evaluative threat paradigm (Trier Social Stress Test; TSST) and social interaction (Trier Social Stress Test- Friendly; TSST-F). Mediation models examined the relationships between anxiety, diagnosis, and physiology. Results Significant three-way interactions were observed for cortisol (p = 0.007) and HR (p = 0.002), suggesting diagnostic groups respond differently across context and time points. There was no significant interaction for RSA (p = 0.149), although ASD youth had significantly lower RSA overall (p = 0.038). State and trait anxiety did not mediate the relationship between diagnosis and physiology (all p > 0.05). Conclusions Findings emphasize the critical role of context and a multisystem approach in examination of physiological social stress in youth with ASD. Results provide a foundation to elucidate unique response patterns across physiological systems to more precisely identify those with heightened physiological arousal across social contexts. It is proposed that future identification of subtypes may ultimately inform approaches for enhancing social engagement. En ligne : https://doi.org/10.1016/j.rasd.2024.102354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

An evaluation of a stepped-care telehealth program for improving the sleep of autistic children / Monique A. C. CLARKE in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102356 Titre : An evaluation of a stepped-care telehealth program for improving the sleep of autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Monique A. C. CLARKE, Auteur ; Laurie K. MCLAY, Auteur ; Karyn G. FRANCE, Auteur ; Neville M. BLAMPIED, Auteur Article en page(s) : p.102356 Langues : Anglais (eng) Mots-clés : Telemedicine  Telehealth  Child  Autistic Disorder  Sleep Initiation and Maintenance Disorders  Intervention Index. décimale : PER Périodiques Résumé : Background Sleep problems are prevalent in Autistic children, adversely affecting their development, well-being and quality of life. Traditional face-to-face behavioral interventions are hindered by accessibility. Using a single-case design, this study evaluated the efficacy of a stepped-care telehealth-delivered behavioral sleep intervention (TDBSI). Method Seven Autistic children (aged 4-8) and their parents participated in a 12-week program consisting of baseline plus three sequential intervention phases: (1) self-directed online parent psychoeducation, (2) small group parent coaching via video conferencing, and (3) individualized parent coaching via video conferencing. Parent strategy selection and implementation fidelity were closely monitored and rated across intervention phases. Child sleep outcomes were assessed through daily parent-reported sleep diaries and the Children's Sleep Habits Questionnaire. Results Five of seven parents used online parent education to independently select antecedent strategies (e.g., sleep hygiene, stimulus control) and/or rewards that were appropriate for their child?s sleep and implemented them with high fidelity. This resulted in reductions in sleep onset latency, night wakings, early wakings, and bedsharing for their children. Parent implementation fidelity and child sleep outcomes were further improved for all participants with group or individualized coaching, and results were maintained at 12 weeks and six months post-intervention. Conclusions TDBSIs show promise in addressing sleep difficulties in Autistic children, warranting further investigation and replication. En ligne : https://doi.org/10.1016/j.rasd.2024.102356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] An evaluation of a stepped-care telehealth program for improving the sleep of autistic children [Texte imprimé et/ou numérique] / Monique A. C. CLARKE, Auteur ; Laurie K. MCLAY, Auteur ; Karyn G. FRANCE, Auteur ; Neville M. BLAMPIED, Auteur . - p.102356. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102356 Mots-clés : Telemedicine  Telehealth  Child  Autistic Disorder  Sleep Initiation and Maintenance Disorders  Intervention Index. décimale : PER Périodiques Résumé : Background Sleep problems are prevalent in Autistic children, adversely affecting their development, well-being and quality of life. Traditional face-to-face behavioral interventions are hindered by accessibility. Using a single-case design, this study evaluated the efficacy of a stepped-care telehealth-delivered behavioral sleep intervention (TDBSI). Method Seven Autistic children (aged 4-8) and their parents participated in a 12-week program consisting of baseline plus three sequential intervention phases: (1) self-directed online parent psychoeducation, (2) small group parent coaching via video conferencing, and (3) individualized parent coaching via video conferencing. Parent strategy selection and implementation fidelity were closely monitored and rated across intervention phases. Child sleep outcomes were assessed through daily parent-reported sleep diaries and the Children's Sleep Habits Questionnaire. Results Five of seven parents used online parent education to independently select antecedent strategies (e.g., sleep hygiene, stimulus control) and/or rewards that were appropriate for their child?s sleep and implemented them with high fidelity. This resulted in reductions in sleep onset latency, night wakings, early wakings, and bedsharing for their children. Parent implementation fidelity and child sleep outcomes were further improved for all participants with group or individualized coaching, and results were maintained at 12 weeks and six months post-intervention. Conclusions TDBSIs show promise in addressing sleep difficulties in Autistic children, warranting further investigation and replication. En ligne : https://doi.org/10.1016/j.rasd.2024.102356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524