Dépouillements

Mortality and Antidepressants Among Individuals With Autism Spectrum Disorder: A Population-Based Cohort Study / Vincent Chin-Hung CHEN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70302 Titre : Mortality and Antidepressants Among Individuals With Autism Spectrum Disorder: A Population-Based Cohort Study Type de document : texte imprimé Auteurs : Vincent Chin-Hung CHEN, Auteur ; Yu-Hsin HUANG, Auteur ; Yi-Lung CHEN, Auteur ; Michael E. DEWEY, Auteur ; Tai-Hsin HUNG, Auteur ; Shu- I. WU, Auteur Article en page(s) : p. e70302 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) often experience premature mortality and co-occurring psychiatric conditions, for which antidepressants are commonly prescribed. However, the long-term safety of antidepressant use in this population remains unclear. Using data from the Taiwan National Health Insurance Research Database, we emulated a target trial to examine the association between antidepressant use and mortality among individuals with ASD aged 6?64?years diagnosed between 2000 and 2016. A three-step approach of cloning, censoring, and inverse probability of censoring weighting was applied to address immortal-time bias. Participants were followed for up to 5?years to assess all-cause, suicide, and accidental-cause mortality. Among 33,939 eligible individuals, 779 initiated antidepressants within a 3-month grace period. Antidepressant use was not associated with all-cause or suicide mortality overall. However, it was significantly associated with reduced accidental-cause mortality at both 2 (HR?=?0.15; 95% CI, 0.04?0.53) and 5?years (HR?=?0.05; 95% CI, 0.01?0.20). Subgroup analysis revealed increased 2-year all-cause mortality among youths (HR?=?4.40; 95% CI, 1.10?17.58) but significantly decreased 5-year accidental mortality in the age groups of 6?15?years (HR?=?0.06; 95% CI, 0.01?0.41) and over 24?years (HR?=?0.06; 95% CI, 0.01?0.42). Additionally, decreased 5-year suicide mortality was observed in the 16?24 age group (HR?=?0.17; 95% CI, 0.05?0.61). While antidepressant use may reduce accidental mortality in individuals with ASD, age-specific risks warrant careful consideration and monitoring, particularly among younger populations. En ligne : https://doi.org/10.1002/aur.70302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Mortality and Antidepressants Among Individuals With Autism Spectrum Disorder: A Population-Based Cohort Study [texte imprimé] / Vincent Chin-Hung CHEN, Auteur ; Yu-Hsin HUANG, Auteur ; Yi-Lung CHEN, Auteur ; Michael E. DEWEY, Auteur ; Tai-Hsin HUNG, Auteur ; Shu- I. WU, Auteur . - p. e70302. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70302 Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) often experience premature mortality and co-occurring psychiatric conditions, for which antidepressants are commonly prescribed. However, the long-term safety of antidepressant use in this population remains unclear. Using data from the Taiwan National Health Insurance Research Database, we emulated a target trial to examine the association between antidepressant use and mortality among individuals with ASD aged 6?64?years diagnosed between 2000 and 2016. A three-step approach of cloning, censoring, and inverse probability of censoring weighting was applied to address immortal-time bias. Participants were followed for up to 5?years to assess all-cause, suicide, and accidental-cause mortality. Among 33,939 eligible individuals, 779 initiated antidepressants within a 3-month grace period. Antidepressant use was not associated with all-cause or suicide mortality overall. However, it was significantly associated with reduced accidental-cause mortality at both 2 (HR?=?0.15; 95% CI, 0.04?0.53) and 5?years (HR?=?0.05; 95% CI, 0.01?0.20). Subgroup analysis revealed increased 2-year all-cause mortality among youths (HR?=?4.40; 95% CI, 1.10?17.58) but significantly decreased 5-year accidental mortality in the age groups of 6?15?years (HR?=?0.06; 95% CI, 0.01?0.41) and over 24?years (HR?=?0.06; 95% CI, 0.01?0.42). Additionally, decreased 5-year suicide mortality was observed in the 16?24 age group (HR?=?0.17; 95% CI, 0.05?0.61). While antidepressant use may reduce accidental mortality in individuals with ASD, age-specific risks warrant careful consideration and monitoring, particularly among younger populations. En ligne : https://doi.org/10.1002/aur.70302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Sexual and Reproductive Healthcare Among Youth With Autism and ADHD: A Population-Based Study From Sweden / Lovisa HELLSTEN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70306 Titre : Sexual and Reproductive Healthcare Among Youth With Autism and ADHD: A Population-Based Study From Sweden Type de document : texte imprimé Auteurs : Lovisa HELLSTEN, Auteur ; Jessica RAST, Auteur ; Anna NIELSEN, Auteur ; Anna Mia EKSTRÖM, Auteur ; Kristina GEMZELL-DANIELSSON, Auteur ; Kyriaki KOSIDOU, Auteur ; Viktor H. AHLQVIST, Auteur Article en page(s) : p. e70306 Langues : Anglais (eng) Mots-clés : adolescent health  adolescent health services  attention deficit disorder with hyperactivity  autism spectrum disorder  health services accessibility  health services for persons with disabilities  preventive health services  reproductive health  sexual health  telemedicine Index. décimale : PER Périodiques Résumé : ABSTRACT Youth with autism spectrum disorder or attention-deficit/hyperactivity disorder (ADHD) may face barriers to sexual and reproductive health (SRH) services. Yet, data on preventive SRH service use remain limited, especially digital care. This population-based registry study investigated whether patterns of SRH service use differed by digital versus in-person care among 12?22-year-olds in Stockholm County (2018?2022). Among 454,405 youth (48.6% female; mean age 16?years), 11,850 were autistic, 31,144 had ADHD, and 9126 had both conditions; the majority of SRH contacts were in-person visits. ADHD youth had higher adjusted Odds Ratios [aOR] of in-person (females: 2.02 [95% CI, 1.93?2.11]; males, 1.46 [1.39?1.54]) and digital visits (females, 1.21 [1.14?1.29]; males, 1.26 [1.05?1.52]) than control peers. Autistic youth had lower aOR of in-person (females, 0.67 [0.63?0.72]; males, 0.45 [0.40?0.51]) and digital visits (females, 0.79 [0.71?0.89]; males, 0.79 [0.54?1.15]). Intensity of use (incidence rate ratios) was higher among ADHD youth but similar among autistic females compared with control peers. Autistic females were more likely to consult physicians but less likely to see midwives or use short-acting contraception. ADHD was associated with higher odds of all provider types, contraceptive methods, and abortion. In conclusion, ADHD youth engaged more and autistic youth less?particularly males?with SRH services than controls. Smaller relative digital than in-person differences suggest digital options might reduce access disparities. Similar intensity of use between autistic and control females suggests barriers may be entry to care, whereas high SRH use among ADHD youth challenges assumptions that low engagement drives risk outcomes. En ligne : https://doi.org/10.1002/aur.70306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Sexual and Reproductive Healthcare Among Youth With Autism and ADHD: A Population-Based Study From Sweden [texte imprimé] / Lovisa HELLSTEN, Auteur ; Jessica RAST, Auteur ; Anna NIELSEN, Auteur ; Anna Mia EKSTRÖM, Auteur ; Kristina GEMZELL-DANIELSSON, Auteur ; Kyriaki KOSIDOU, Auteur ; Viktor H. AHLQVIST, Auteur . - p. e70306. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70306 Mots-clés : adolescent health  adolescent health services  attention deficit disorder with hyperactivity  autism spectrum disorder  health services accessibility  health services for persons with disabilities  preventive health services  reproductive health  sexual health  telemedicine Index. décimale : PER Périodiques Résumé : ABSTRACT Youth with autism spectrum disorder or attention-deficit/hyperactivity disorder (ADHD) may face barriers to sexual and reproductive health (SRH) services. Yet, data on preventive SRH service use remain limited, especially digital care. This population-based registry study investigated whether patterns of SRH service use differed by digital versus in-person care among 12?22-year-olds in Stockholm County (2018?2022). Among 454,405 youth (48.6% female; mean age 16?years), 11,850 were autistic, 31,144 had ADHD, and 9126 had both conditions; the majority of SRH contacts were in-person visits. ADHD youth had higher adjusted Odds Ratios [aOR] of in-person (females: 2.02 [95% CI, 1.93?2.11]; males, 1.46 [1.39?1.54]) and digital visits (females, 1.21 [1.14?1.29]; males, 1.26 [1.05?1.52]) than control peers. Autistic youth had lower aOR of in-person (females, 0.67 [0.63?0.72]; males, 0.45 [0.40?0.51]) and digital visits (females, 0.79 [0.71?0.89]; males, 0.79 [0.54?1.15]). Intensity of use (incidence rate ratios) was higher among ADHD youth but similar among autistic females compared with control peers. Autistic females were more likely to consult physicians but less likely to see midwives or use short-acting contraception. ADHD was associated with higher odds of all provider types, contraceptive methods, and abortion. In conclusion, ADHD youth engaged more and autistic youth less?particularly males?with SRH services than controls. Smaller relative digital than in-person differences suggest digital options might reduce access disparities. Similar intensity of use between autistic and control females suggests barriers may be entry to care, whereas high SRH use among ADHD youth challenges assumptions that low engagement drives risk outcomes. En ligne : https://doi.org/10.1002/aur.70306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder / Borja RODRIGUEZ-HERREROS in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70315 Titre : Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Borja RODRIGUEZ-HERREROS, Auteur ; Ahmad MHEICH, Auteur ; Joana Maria Almeida OSORIO, Auteur ; Sonia RICHETIN, Auteur ; Vincent JUNOD, Auteur ; Lorène ARNOLD, Auteur ; Victoria AESCHBACH, Auteur ; Lilia Nora ADAMOU, Auteur ; Katherina GSCHWEND, Auteur ; Laura MENDES, Auteur ; David ROMASCANO, Auteur ; Paola YU, Auteur ; Marine Jequier GYGAX, Auteur ; Anne M. MAILLARD, Auteur ; Micah M. MURRAY, Auteur ; Mahmoud HASSAN, Auteur ; Nadia CHABANE, Auteur Article en page(s) : p. e70315 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT The heterogeneity in both the neurobiological mechanisms and the phenotypic presentations of autism spectrum disorder (ASD) poses a major challenge to clinical and translational research. Alterations in functional connectivity (FC) have been associated with ASD, yet it remains unclear whether and how divergent brain network properties may account for individual differences across ASD-related symptomatology and behaviors. We applied source-level reconstruction to rest-like non-task-related high-density EEG data in a cohort of 104 young children (38 with ASD) to identify global and local alterations of cortical network connectivity. We subsequently used regularized canonical correlation analysis (rCCA) to characterize specific FC patterns linked to variation in cognitive, social and sensory dimensions derived from standard clinical instruments. We found increased low-frequency FC in frontotemporal cross-hemispheric networks and lateral-occipital regions of young ASD children versus healthy peers. RCCA revealed three distinct FC patterns in recurrent ASD-related networks, each contributing to predict individual differences in cognitive, social and sensory features. These linked FC-behavior dimensions may shed light on atypical brain network topology associated with specific phenotypic manifestations of ASD, which might implicate unique underlying neurobiological mechanisms. En ligne : https://doi.org/10.1002/aur.70315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder [texte imprimé] / Borja RODRIGUEZ-HERREROS, Auteur ; Ahmad MHEICH, Auteur ; Joana Maria Almeida OSORIO, Auteur ; Sonia RICHETIN, Auteur ; Vincent JUNOD, Auteur ; Lorène ARNOLD, Auteur ; Victoria AESCHBACH, Auteur ; Lilia Nora ADAMOU, Auteur ; Katherina GSCHWEND, Auteur ; Laura MENDES, Auteur ; David ROMASCANO, Auteur ; Paola YU, Auteur ; Marine Jequier GYGAX, Auteur ; Anne M. MAILLARD, Auteur ; Micah M. MURRAY, Auteur ; Mahmoud HASSAN, Auteur ; Nadia CHABANE, Auteur . - p. e70315. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70315 Index. décimale : PER Périodiques Résumé : ABSTRACT The heterogeneity in both the neurobiological mechanisms and the phenotypic presentations of autism spectrum disorder (ASD) poses a major challenge to clinical and translational research. Alterations in functional connectivity (FC) have been associated with ASD, yet it remains unclear whether and how divergent brain network properties may account for individual differences across ASD-related symptomatology and behaviors. We applied source-level reconstruction to rest-like non-task-related high-density EEG data in a cohort of 104 young children (38 with ASD) to identify global and local alterations of cortical network connectivity. We subsequently used regularized canonical correlation analysis (rCCA) to characterize specific FC patterns linked to variation in cognitive, social and sensory dimensions derived from standard clinical instruments. We found increased low-frequency FC in frontotemporal cross-hemispheric networks and lateral-occipital regions of young ASD children versus healthy peers. RCCA revealed three distinct FC patterns in recurrent ASD-related networks, each contributing to predict individual differences in cognitive, social and sensory features. These linked FC-behavior dimensions may shed light on atypical brain network topology associated with specific phenotypic manifestations of ASD, which might implicate unique underlying neurobiological mechanisms. En ligne : https://doi.org/10.1002/aur.70315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

‘They Even Have the Capacity, but the Places Aren't Prepared to Receive Them’: Community Environment and Participation of Autistic Children in a Family-Engaged Research Analysis / Léia Cordeiro DE OLIVEIRA in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70316 Titre : ‘They Even Have the Capacity, but the Places Aren't Prepared to Receive Them’: Community Environment and Participation of Autistic Children in a Family-Engaged Research Analysis Type de document : texte imprimé Auteurs : Léia Cordeiro DE OLIVEIRA, Auteur ; Cid André Fidelis DE PAULA GOMES, Auteur ; Gustavo Pietracatelli JANIZELLO, Auteur ; Wallace Pereira SILVA, Auteur ; Alice SOPER, Auteur ; Monika NOVAK-PAVLIC, Auteur ; Olaf Kraus DE CAMARGO, Auteur ; Soraia Micaela SILVA, Auteur Article en page(s) : p. e70316 Langues : Anglais (eng) Mots-clés : autism  children  community  disability and health  international classification of functioning  participation  patient and public involvement  social environment Index. décimale : PER Périodiques Résumé : ABSTRACT To examine the associations between community environmental barriers and support and the participation of autistic children, and to interpret these findings from the perspective of caregivers engaged as research partners. This cross-sectional observational study employed a mixed-methods design. The first phase comprised analytical and exploratory quantitative analyses. Caregivers of autistic children aged 5?12?years reported participation outcomes?frequency, involvement, and desire for change?using the Brazilian version of the Participation and Environment Measure for Children and Youth (PEM-CY) and CARS-BR with 80 caregivers of children aged 5?12. Phase 1 involved path analysis to test associations between community environment, income, autism severity, and participation (frequency, involvement, desire for change). Phase 2 employed a constructivist-interpretivist approach, where five caregivers acted as research partners to interpret quantitative results via reflexive thematic analysis. Quantitative analysis showed no statistically significant associations between environmental factors and participation outcomes, despite frequent reports of barriers. In Phase 2, research partners identified social inclusion, safety, and logistical constraints as critical. They highlighted that low participation often stems from unwelcoming contexts and limited informal peer interaction, rather than a lack of desire to engage. Integrating findings from both phases, the study suggests that the low participation of autistic children in community settings may reflect, at least in part, protective choices adopted in response to contexts perceived as unwelcoming, unsafe, and insufficiently supportive, rather than a lack of desire for participation. En ligne : https://doi.org/10.1002/aur.70316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] ‘They Even Have the Capacity, but the Places Aren't Prepared to Receive Them’: Community Environment and Participation of Autistic Children in a Family-Engaged Research Analysis [texte imprimé] / Léia Cordeiro DE OLIVEIRA, Auteur ; Cid André Fidelis DE PAULA GOMES, Auteur ; Gustavo Pietracatelli JANIZELLO, Auteur ; Wallace Pereira SILVA, Auteur ; Alice SOPER, Auteur ; Monika NOVAK-PAVLIC, Auteur ; Olaf Kraus DE CAMARGO, Auteur ; Soraia Micaela SILVA, Auteur . - p. e70316. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70316 Mots-clés : autism  children  community  disability and health  international classification of functioning  participation  patient and public involvement  social environment Index. décimale : PER Périodiques Résumé : ABSTRACT To examine the associations between community environmental barriers and support and the participation of autistic children, and to interpret these findings from the perspective of caregivers engaged as research partners. This cross-sectional observational study employed a mixed-methods design. The first phase comprised analytical and exploratory quantitative analyses. Caregivers of autistic children aged 5?12?years reported participation outcomes?frequency, involvement, and desire for change?using the Brazilian version of the Participation and Environment Measure for Children and Youth (PEM-CY) and CARS-BR with 80 caregivers of children aged 5?12. Phase 1 involved path analysis to test associations between community environment, income, autism severity, and participation (frequency, involvement, desire for change). Phase 2 employed a constructivist-interpretivist approach, where five caregivers acted as research partners to interpret quantitative results via reflexive thematic analysis. Quantitative analysis showed no statistically significant associations between environmental factors and participation outcomes, despite frequent reports of barriers. In Phase 2, research partners identified social inclusion, safety, and logistical constraints as critical. They highlighted that low participation often stems from unwelcoming contexts and limited informal peer interaction, rather than a lack of desire to engage. Integrating findings from both phases, the study suggests that the low participation of autistic children in community settings may reflect, at least in part, protective choices adopted in response to contexts perceived as unwelcoming, unsafe, and insufficiently supportive, rather than a lack of desire for participation. En ligne : https://doi.org/10.1002/aur.70316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Development and Validation of a Japanese Version of the Sensory Experience Questionnaire (SEQ) 3.0: Structural Differences of Sensory Features Across Autistic Children / Takeshi ATSUMI in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70317 Titre : Development and Validation of a Japanese Version of the Sensory Experience Questionnaire (SEQ) 3.0: Structural Differences of Sensory Features Across Autistic Children Type de document : texte imprimé Auteurs : Takeshi ATSUMI, Auteur ; Haruka ITO, Auteur ; Akane SHINJO, Auteur ; Tomoe FUKUTOMI, Auteur ; Yasuo TERAO, Auteur ; Masakazu IDE, Auteur ; Kanae MATSUSHIMA, Auteur Article en page(s) : p. e70317 Langues : Anglais (eng) Mots-clés : attention-deficit hyperactivity disorder  autism spectrum disorder  representational similarity analysis  sensory experience questionnaire  sensory feature Index. décimale : PER Périodiques Résumé : ABSTRACT People with autism spectrum disorder (ASD) often have unique sensory experiences. For both research and clinical purposes, tools that measure sensory features in autism are valuable; however, a gold-standard tool does not yet exist. The Sensory Experience Questionnaire (SEQ) 3.0 is a well-established caregiver-/parent-report questionnaire for autistic children and other neurodivergent individuals. This study aimed to develop and psychometrically validate the Japanese version of the SEQ 3.0 (SEQ-J). After validation, we examined the differences in sensory response patterns among children with ASD, those with other neurodevelopmental conditions, and typically developing (TD) children to determine whether the SEQ assesses ASD-specific sensory features. We recruited 154 children with ASD (44 with attention-deficit hyperactivity disorder [ADHD] and 66 with other conditions) and 156 TD children, aged 6?12?years. Confirmatory factor analyses revealed an acceptable model fit for four content factors (sensory hyper- and hyporesponsiveness, sensory interests, repetitive and seeking behaviors, and enhanced perception) and six method factors (five sensory modalities and social context) in both children with and without ASD. We performed representational similarity analyses (RSAs) on all 10 SEQ factors, comparing both between- and within-group data. The RSAs revealed no difference in within-group similarities between the ASD group with no other developmental conditions and ASD?+?ADHD groups, but a significant difference in the overall configuration of scores between diagnostic groups compared to other group combinations. These findings support the psychometric validity of the SEQ-J for measuring sensory response patterns specific to children with ASD. Additionally, the structural configuration of SEQ subscores may be useful for investigating sensory features across diagnostic conditions, including ASD. En ligne : https://doi.org/10.1002/aur.70317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Development and Validation of a Japanese Version of the Sensory Experience Questionnaire (SEQ) 3.0: Structural Differences of Sensory Features Across Autistic Children [texte imprimé] / Takeshi ATSUMI, Auteur ; Haruka ITO, Auteur ; Akane SHINJO, Auteur ; Tomoe FUKUTOMI, Auteur ; Yasuo TERAO, Auteur ; Masakazu IDE, Auteur ; Kanae MATSUSHIMA, Auteur . - p. e70317. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70317 Mots-clés : attention-deficit hyperactivity disorder  autism spectrum disorder  representational similarity analysis  sensory experience questionnaire  sensory feature Index. décimale : PER Périodiques Résumé : ABSTRACT People with autism spectrum disorder (ASD) often have unique sensory experiences. For both research and clinical purposes, tools that measure sensory features in autism are valuable; however, a gold-standard tool does not yet exist. The Sensory Experience Questionnaire (SEQ) 3.0 is a well-established caregiver-/parent-report questionnaire for autistic children and other neurodivergent individuals. This study aimed to develop and psychometrically validate the Japanese version of the SEQ 3.0 (SEQ-J). After validation, we examined the differences in sensory response patterns among children with ASD, those with other neurodevelopmental conditions, and typically developing (TD) children to determine whether the SEQ assesses ASD-specific sensory features. We recruited 154 children with ASD (44 with attention-deficit hyperactivity disorder [ADHD] and 66 with other conditions) and 156 TD children, aged 6?12?years. Confirmatory factor analyses revealed an acceptable model fit for four content factors (sensory hyper- and hyporesponsiveness, sensory interests, repetitive and seeking behaviors, and enhanced perception) and six method factors (five sensory modalities and social context) in both children with and without ASD. We performed representational similarity analyses (RSAs) on all 10 SEQ factors, comparing both between- and within-group data. The RSAs revealed no difference in within-group similarities between the ASD group with no other developmental conditions and ASD?+?ADHD groups, but a significant difference in the overall configuration of scores between diagnostic groups compared to other group combinations. These findings support the psychometric validity of the SEQ-J for measuring sensory response patterns specific to children with ASD. Additionally, the structural configuration of SEQ subscores may be useful for investigating sensory features across diagnostic conditions, including ASD. En ligne : https://doi.org/10.1002/aur.70317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Through Parents' Eyes: Perspectives on Child Development and Family Experience During ESDM Intervention / Kenza LATRÈCHE in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70318 Titre : Through Parents' Eyes: Perspectives on Child Development and Family Experience During ESDM Intervention Type de document : texte imprimé Auteurs : Kenza LATRÈCHE, Auteur ; Fiona JOURNAL, Auteur ; Michel GODEL, Auteur ; Martina FRANCHINI, Auteur ; Nada KOJOVIC, Auteur ; David CIMASONI, Auteur ; Marcin CZAJKOWSKI, Auteur ; Lucie DELIEUTRAZ, Auteur ; Chloé LAUBU, Auteur ; Marie SCHAER, Auteur Article en page(s) : p. e70318 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  children  early intervention  Early Start Denver Model  parental perspectives  parenting skills  well-being Index. décimale : PER Périodiques Résumé : ABSTRACT Early intensive intervention for autistic children aims to support developmental progress in social and communication domains. Although outcomes are typically assessed using standardized measures of child development, parental perspectives during early intervention remain largely understudied. Here, we examined parental perceptions after 6?months of intensive Early Start Denver Model (ESDM) intervention. Participants were parents of 104 autistic children aged 1.3?3.5?years enrolled in an individualized therapist-delivered ESDM intervention following diagnosis confirmation. Child development was assessed at entry (baseline) and 6?months later (follow-up). At follow-up, parents completed an 18-item questionnaire capturing their perceptions of child progress across twelve domains as well as changes in parenting skills, personal well-being, and family life. Descriptive analyses, item-level correlations, and principal component analysis (PCA) were conducted to identify underlying components. Parents generally indicated improvements across all domains, with aggravation rarely reported. PCA revealed three intercorrelated components (Social Communication, Nonverbal Social Engagement, and Positive Parental Experience), each showing distinct associations with child or parent measures. Parental perceptions of child development were strongly correlated with standardized developmental assessments, particularly in social communication. While parents also reported enhanced parenting skills and positive personal and familial impacts, these experiences were not associated with child developmental gains but with parental education and the number of siblings in the household. These findings underscore the importance of integrating parental perspectives alongside clinical assessments when evaluating early intervention outcomes. Future research should investigate how parental perceptions evolve over longer periods and how they may inform family-centered care and post-intervention support. En ligne : https://doi.org/10.1002/aur.70318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Through Parents' Eyes: Perspectives on Child Development and Family Experience During ESDM Intervention [texte imprimé] / Kenza LATRÈCHE, Auteur ; Fiona JOURNAL, Auteur ; Michel GODEL, Auteur ; Martina FRANCHINI, Auteur ; Nada KOJOVIC, Auteur ; David CIMASONI, Auteur ; Marcin CZAJKOWSKI, Auteur ; Lucie DELIEUTRAZ, Auteur ; Chloé LAUBU, Auteur ; Marie SCHAER, Auteur . - p. e70318. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70318 Mots-clés : autism spectrum disorder  children  early intervention  Early Start Denver Model  parental perspectives  parenting skills  well-being Index. décimale : PER Périodiques Résumé : ABSTRACT Early intensive intervention for autistic children aims to support developmental progress in social and communication domains. Although outcomes are typically assessed using standardized measures of child development, parental perspectives during early intervention remain largely understudied. Here, we examined parental perceptions after 6?months of intensive Early Start Denver Model (ESDM) intervention. Participants were parents of 104 autistic children aged 1.3?3.5?years enrolled in an individualized therapist-delivered ESDM intervention following diagnosis confirmation. Child development was assessed at entry (baseline) and 6?months later (follow-up). At follow-up, parents completed an 18-item questionnaire capturing their perceptions of child progress across twelve domains as well as changes in parenting skills, personal well-being, and family life. Descriptive analyses, item-level correlations, and principal component analysis (PCA) were conducted to identify underlying components. Parents generally indicated improvements across all domains, with aggravation rarely reported. PCA revealed three intercorrelated components (Social Communication, Nonverbal Social Engagement, and Positive Parental Experience), each showing distinct associations with child or parent measures. Parental perceptions of child development were strongly correlated with standardized developmental assessments, particularly in social communication. While parents also reported enhanced parenting skills and positive personal and familial impacts, these experiences were not associated with child developmental gains but with parental education and the number of siblings in the household. These findings underscore the importance of integrating parental perspectives alongside clinical assessments when evaluating early intervention outcomes. Future research should investigate how parental perceptions evolve over longer periods and how they may inform family-centered care and post-intervention support. En ligne : https://doi.org/10.1002/aur.70318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Language Adaptation of Young Bilingual Autistic Children During Semi-Naturalistic Interactions With Their Caregivers / Pauline MAES in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70319 Titre : Language Adaptation of Young Bilingual Autistic Children During Semi-Naturalistic Interactions With Their Caregivers Type de document : texte imprimé Auteurs : Pauline MAES, Auteur ; Maira TAFOLLA, Auteur ; Nurit BENREY, Auteur ; Nicole ROSEN, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Catherine LORD, Auteur Article en page(s) : p. e70319 Langues : Anglais (eng) Mots-clés : bilingualism  code-switching  language development  minimally speaking  naturalistic language sample Index. décimale : PER Périodiques Résumé : ABSTRACT Although bilingualism is now recognized as having no adverse effects on language outcomes in autistic children, little is known about how it manifests in early development, particularly in minimally speaking children who may show unique patterns of bilingual expression. The present study used naturalistic language sampling to characterize bilingual language use in minimally speaking autistic children and their caregivers. Video recordings of 31 minimally speaking autistic children interacting with their caregivers during two separate sessions of the Brief Observation of Symptoms of Autism (BOSA)?one in English and one in Spanish?were transcribed and analyzed for language skills (mean length of utterance in words, number of different words), speaking rate (utterances per minute), and use of English, Spanish, or mixed-language utterances. We found that children were slightly more proficient in English than in Spanish, especially in the number of different words. Both children and caregivers produced similar rates of speech across the English and Spanish BOSA sessions, suggesting that language choice did not quantitatively impact their interaction. Finally, children aligned with their caregivers' language use more consistently in English than in Spanish. Although they responded in Spanish when caregivers used Spanish, they also switched into English a lot during the Spanish BOSA. These findings suggest that minimally speaking autistic children flexibly adapt to their caregiver's language while showing an early advantage or preference for their societally dominant language. En ligne : https://doi.org/10.1002/aur.70319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Language Adaptation of Young Bilingual Autistic Children During Semi-Naturalistic Interactions With Their Caregivers [texte imprimé] / Pauline MAES, Auteur ; Maira TAFOLLA, Auteur ; Nurit BENREY, Auteur ; Nicole ROSEN, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Catherine LORD, Auteur . - p. e70319. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70319 Mots-clés : bilingualism  code-switching  language development  minimally speaking  naturalistic language sample Index. décimale : PER Périodiques Résumé : ABSTRACT Although bilingualism is now recognized as having no adverse effects on language outcomes in autistic children, little is known about how it manifests in early development, particularly in minimally speaking children who may show unique patterns of bilingual expression. The present study used naturalistic language sampling to characterize bilingual language use in minimally speaking autistic children and their caregivers. Video recordings of 31 minimally speaking autistic children interacting with their caregivers during two separate sessions of the Brief Observation of Symptoms of Autism (BOSA)?one in English and one in Spanish?were transcribed and analyzed for language skills (mean length of utterance in words, number of different words), speaking rate (utterances per minute), and use of English, Spanish, or mixed-language utterances. We found that children were slightly more proficient in English than in Spanish, especially in the number of different words. Both children and caregivers produced similar rates of speech across the English and Spanish BOSA sessions, suggesting that language choice did not quantitatively impact their interaction. Finally, children aligned with their caregivers' language use more consistently in English than in Spanish. Although they responded in Spanish when caregivers used Spanish, they also switched into English a lot during the Spanish BOSA. These findings suggest that minimally speaking autistic children flexibly adapt to their caregiver's language while showing an early advantage or preference for their societally dominant language. En ligne : https://doi.org/10.1002/aur.70319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Neural Endophenotypes of Semantic Processing and Social Functioning in Autism Spectrum Disorder / Shu-Hui LEE in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70320 Titre : Neural Endophenotypes of Semantic Processing and Social Functioning in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Shu-Hui LEE, Auteur ; Chuan-Ching LIAO, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p. e70320 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  endophenotype  fMRI  semantic  social Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is highly heritable; however, the neural architecture underlying semantic processing and social functioning, and the extent to which it reflects familial liability, remains insufficiently understood. Unaffected siblings (SIB), who share substantial genetic liability with individuals with ASD, offer a critical framework for identifying intermediate neural phenotypes. We examined 36 individuals with ASD, 36 SIB, and 37 typically developing (TD) controls, matched for age, IQ, and handedness. Functional magnetic resonance imaging (fMRI) during a semantic judgment task was used to compare neural activation across groups and to assess whether associations with social functioning, measured by the Social Responsiveness Scale (SRS), reflected familial risk or dimensional continuity across the autism spectrum. Group comparisons revealed a graded endophenotypic pattern in inferior frontal gyrus (IFG) activation, with reduced activation in ASD and intermediate responses in SIB. The middle temporal gyrus (MTG) showed a similar but weaker gradient, with SIB not differing significantly from TD. Both ASD and SIB also demonstrated heightened cuneus activation, consistent with a heritable compensatory shift toward perceptual processing. Importantly, reduced MTG activation, along with a weaker marginal pattern in the IFG, was associated with higher SRS scores in both the familial and full samples, suggesting an association between semantic activation and social functioning. These findings clarify how familial liability and dimensional variation jointly shape the neural organization of semantic processing and social functioning in ASD. En ligne : https://doi.org/10.1002/aur.70320 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Neural Endophenotypes of Semantic Processing and Social Functioning in Autism Spectrum Disorder [texte imprimé] / Shu-Hui LEE, Auteur ; Chuan-Ching LIAO, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur . - p. e70320. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70320 Mots-clés : autism spectrum disorder  endophenotype  fMRI  semantic  social Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is highly heritable; however, the neural architecture underlying semantic processing and social functioning, and the extent to which it reflects familial liability, remains insufficiently understood. Unaffected siblings (SIB), who share substantial genetic liability with individuals with ASD, offer a critical framework for identifying intermediate neural phenotypes. We examined 36 individuals with ASD, 36 SIB, and 37 typically developing (TD) controls, matched for age, IQ, and handedness. Functional magnetic resonance imaging (fMRI) during a semantic judgment task was used to compare neural activation across groups and to assess whether associations with social functioning, measured by the Social Responsiveness Scale (SRS), reflected familial risk or dimensional continuity across the autism spectrum. Group comparisons revealed a graded endophenotypic pattern in inferior frontal gyrus (IFG) activation, with reduced activation in ASD and intermediate responses in SIB. The middle temporal gyrus (MTG) showed a similar but weaker gradient, with SIB not differing significantly from TD. Both ASD and SIB also demonstrated heightened cuneus activation, consistent with a heritable compensatory shift toward perceptual processing. Importantly, reduced MTG activation, along with a weaker marginal pattern in the IFG, was associated with higher SRS scores in both the familial and full samples, suggesting an association between semantic activation and social functioning. These findings clarify how familial liability and dimensional variation jointly shape the neural organization of semantic processing and social functioning in ASD. En ligne : https://doi.org/10.1002/aur.70320 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Socioeconomic Status and Quantity of Shared Book Reading, But Not Screen Time, are Positively Associated With Language Skills in a Nationally Representative Sample of Autistic Children / M. PECUKONIS in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70321 Titre : Socioeconomic Status and Quantity of Shared Book Reading, But Not Screen Time, are Positively Associated With Language Skills in a Nationally Representative Sample of Autistic Children Type de document : texte imprimé Auteurs : M. PECUKONIS, Auteur ; A. GEFFIN, Auteur Article en page(s) : p. e70321 Langues : Anglais (eng) Mots-clés : autism  language  screen time  SES  shared book reading Index. décimale : PER Périodiques Résumé : ABSTRACT Studies have shown that both distal and proximal environmental factors influence language development in neurotypical children. More specifically, higher socioeconomic status (SES) and more frequent shared book reading have been linked to higher language skills in neurotypical children, while higher screen time has been linked to lower language skills. However, little research has focused on understanding how the environment shapes language development in autistic children, who often experience challenges using and/or understanding spoken language. The present study used data from the 2018?2022 United States National Survey of Children's Health to investigate the associations between SES, quantity of shared book reading and screen time experienced at home, and expressive and receptive language skills in a nationally representative sample of two to five year old autistic children. Structural equation modeling revealed that autistic children from higher SES households, and who experienced shared book reading more frequently at home, had higher expressive and receptive language skills. Shared book reading also mediated the association between SES and children's language skills. Contrary to what has been found in previous studies of neurotypical children, screen time was not associated with autistic children's expressive or receptive language skills. In all, findings suggest that distal (SES) and proximal (shared book reading) environmental factors play an important role in autistic children's language development. Findings have important implications for clinical practice, as interventions that promote frequent shared book reading may support autistic children's language development. En ligne : https://doi.org/10.1002/aur.70321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Socioeconomic Status and Quantity of Shared Book Reading, But Not Screen Time, are Positively Associated With Language Skills in a Nationally Representative Sample of Autistic Children [texte imprimé] / M. PECUKONIS, Auteur ; A. GEFFIN, Auteur . - p. e70321. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70321 Mots-clés : autism  language  screen time  SES  shared book reading Index. décimale : PER Périodiques Résumé : ABSTRACT Studies have shown that both distal and proximal environmental factors influence language development in neurotypical children. More specifically, higher socioeconomic status (SES) and more frequent shared book reading have been linked to higher language skills in neurotypical children, while higher screen time has been linked to lower language skills. However, little research has focused on understanding how the environment shapes language development in autistic children, who often experience challenges using and/or understanding spoken language. The present study used data from the 2018?2022 United States National Survey of Children's Health to investigate the associations between SES, quantity of shared book reading and screen time experienced at home, and expressive and receptive language skills in a nationally representative sample of two to five year old autistic children. Structural equation modeling revealed that autistic children from higher SES households, and who experienced shared book reading more frequently at home, had higher expressive and receptive language skills. Shared book reading also mediated the association between SES and children's language skills. Contrary to what has been found in previous studies of neurotypical children, screen time was not associated with autistic children's expressive or receptive language skills. In all, findings suggest that distal (SES) and proximal (shared book reading) environmental factors play an important role in autistic children's language development. Findings have important implications for clinical practice, as interventions that promote frequent shared book reading may support autistic children's language development. En ligne : https://doi.org/10.1002/aur.70321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Night-to-Night Changes in REM Sleep Are Associated With Symptom Severity in Children With Autism Spectrum Disorder: A Two-Night Home Polysomnography Study / Jian JIAO in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70322 Titre : Night-to-Night Changes in REM Sleep Are Associated With Symptom Severity in Children With Autism Spectrum Disorder: A Two-Night Home Polysomnography Study Type de document : texte imprimé Auteurs : Jian JIAO, Auteur ; Hang ZHANG, Auteur ; Xia YANG, Auteur ; Lu TAN, Auteur ; Taomei LI, Auteur ; Xiangdong TANG, Auteur Article en page(s) : p. e70322 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  night-to-night variability  polysomnography  REM sleep  symptom severity Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep disturbances are highly prevalent in autism spectrum disorder (ASD), yet conventional single-night polysomnography (PSG) provides limited insight into dynamic sleep regulatory processes. Using the Synaptic Homeostasis Hypothesis as a conceptual framework, we quantified night-to-night changes (?; Night 2???Night 1) in sleep architecture across two consecutive nights of home-based PSG and examined their association with ASD symptom severity. Seventy-nine children with ASD, stratified into mild ASD (M-ASD, n?=?35) and moderate-to-severe ASD (MS-ASD, n?=?44) subgroups using the Childhood Autism Rating Scale, and 30 typically developing controls (TDC) participated. Overall sleep-continuity changes were broadly comparable between ASD and TDC groups. However, sleep-architecture ? measures showed a severity-related pattern: the M-ASD subgroup exhibited an overnight increase in rapid eye movement sleep percentage (?REM%?=?+2.6%, p?=?0.002), whereas the MS-ASD subgroup showed no significant change (?REM%?=??0.1%, p?=?0.922). An adjusted pairwise comparison indicated a greater ?REM% increase in M-ASD than in MS-ASD (adjusted mean difference?=?3.4%, 95% CI: 1.2 to 5.6; Bonferroni-corrected p?=?0.009). A similar exploratory difference was observed for NREM1%. ?REM% was modestly and negatively associated with ASD symptom severity in correlation analysis (??=??0.234, p?=?0.038) and age- and gender-adjusted regression analysis (??=??0.286, p?=?0.016). Sensitivity analyses showed broadly consistent patterns, although severity-stratified overall effects were attenuated after FDR correction. These findings support further investigation of PSG-derived dynamic sleep measures as hypothesis-generating correlates of clinical heterogeneity in ASD. En ligne : https://doi.org/10.1002/aur.70322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Night-to-Night Changes in REM Sleep Are Associated With Symptom Severity in Children With Autism Spectrum Disorder: A Two-Night Home Polysomnography Study [texte imprimé] / Jian JIAO, Auteur ; Hang ZHANG, Auteur ; Xia YANG, Auteur ; Lu TAN, Auteur ; Taomei LI, Auteur ; Xiangdong TANG, Auteur . - p. e70322. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70322 Mots-clés : autism spectrum disorder  night-to-night variability  polysomnography  REM sleep  symptom severity Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep disturbances are highly prevalent in autism spectrum disorder (ASD), yet conventional single-night polysomnography (PSG) provides limited insight into dynamic sleep regulatory processes. Using the Synaptic Homeostasis Hypothesis as a conceptual framework, we quantified night-to-night changes (?; Night 2???Night 1) in sleep architecture across two consecutive nights of home-based PSG and examined their association with ASD symptom severity. Seventy-nine children with ASD, stratified into mild ASD (M-ASD, n?=?35) and moderate-to-severe ASD (MS-ASD, n?=?44) subgroups using the Childhood Autism Rating Scale, and 30 typically developing controls (TDC) participated. Overall sleep-continuity changes were broadly comparable between ASD and TDC groups. However, sleep-architecture ? measures showed a severity-related pattern: the M-ASD subgroup exhibited an overnight increase in rapid eye movement sleep percentage (?REM%?=?+2.6%, p?=?0.002), whereas the MS-ASD subgroup showed no significant change (?REM%?=??0.1%, p?=?0.922). An adjusted pairwise comparison indicated a greater ?REM% increase in M-ASD than in MS-ASD (adjusted mean difference?=?3.4%, 95% CI: 1.2 to 5.6; Bonferroni-corrected p?=?0.009). A similar exploratory difference was observed for NREM1%. ?REM% was modestly and negatively associated with ASD symptom severity in correlation analysis (??=??0.234, p?=?0.038) and age- and gender-adjusted regression analysis (??=??0.286, p?=?0.016). Sensitivity analyses showed broadly consistent patterns, although severity-stratified overall effects were attenuated after FDR correction. These findings support further investigation of PSG-derived dynamic sleep measures as hypothesis-generating correlates of clinical heterogeneity in ASD. En ligne : https://doi.org/10.1002/aur.70322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Counting, Cardinality and Conservation in Autistic Children / Irene POLO-BLANCO in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70323 Titre : Counting, Cardinality and Conservation in Autistic Children Type de document : texte imprimé Auteurs : Irene POLO-BLANCO, Auteur ; Raúl FERNÁNDEZ-COBOS, Auteur ; Agustín VICENTE, Auteur Article en page(s) : p. e70323 Langues : Anglais (eng) Mots-clés : autism  cardinality  conservation  counting  equinumerosity  subitization Index. décimale : PER Périodiques Résumé : ABSTRACT This study examined the understanding of cardinality and conservation in children with and without autism (aged 4?7?years, without intellectual disability), and its relation to counting strategies. A total of 82 children participated in the study, including 41 autistic children (36 boys, 5 girls) and 41 age- and sex-matched non-autistic peers. While both groups demonstrated similar mastery of cardinality, autistic children showed lower performance in conservation tasks. Response times were longer in autistic children during counting tasks. Concerning counting strategies, autistic children relied more on verbal counting with pointing (VCP) and used the rapid recognition strategy (N) less frequently, even for small canonical sets. While both strategies (N and VCP) supported cardinality in both autistic and non-autistic children, only the N strategy appeared closely linked to successful conservation performance. These findings highlight two areas of relative difficulty for some autistic children and point to the potential of targeted interventions to strengthen foundational numerical skills and support later mathematical development. En ligne : https://doi.org/10.1002/aur.70323 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Counting, Cardinality and Conservation in Autistic Children [texte imprimé] / Irene POLO-BLANCO, Auteur ; Raúl FERNÁNDEZ-COBOS, Auteur ; Agustín VICENTE, Auteur . - p. e70323. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70323 Mots-clés : autism  cardinality  conservation  counting  equinumerosity  subitization Index. décimale : PER Périodiques Résumé : ABSTRACT This study examined the understanding of cardinality and conservation in children with and without autism (aged 4?7?years, without intellectual disability), and its relation to counting strategies. A total of 82 children participated in the study, including 41 autistic children (36 boys, 5 girls) and 41 age- and sex-matched non-autistic peers. While both groups demonstrated similar mastery of cardinality, autistic children showed lower performance in conservation tasks. Response times were longer in autistic children during counting tasks. Concerning counting strategies, autistic children relied more on verbal counting with pointing (VCP) and used the rapid recognition strategy (N) less frequently, even for small canonical sets. While both strategies (N and VCP) supported cardinality in both autistic and non-autistic children, only the N strategy appeared closely linked to successful conservation performance. These findings highlight two areas of relative difficulty for some autistic children and point to the potential of targeted interventions to strengthen foundational numerical skills and support later mathematical development. En ligne : https://doi.org/10.1002/aur.70323 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Defining Language Profiles in Young Autistic Children Across Verbal, Speaking, and Generative Dimensions / Federica BECCARIA in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70324 Titre : Defining Language Profiles in Young Autistic Children Across Verbal, Speaking, and Generative Dimensions Type de document : texte imprimé Auteurs : Federica BECCARIA, Auteur ; Liesl LEENEN, Auteur ; Marie KOLENBERG, Auteur ; Klaartje VERTONGEN, Auteur ; Ellen DEMURIE, Auteur ; Marielle WEYLAND, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur ; Ilse NOENS, Auteur ; L. A. S. Consortium BE, Auteur ; Inge ZINK, Auteur ; Mikhail KISSINE, Auteur Article en page(s) : p. e70324 Langues : Anglais (eng) Mots-clés : at-home recordings  autism  language development  language generativity  spoken production  verbal skills Index. décimale : PER Périodiques Résumé : ABSTRACT Language trajectories in autism are highly heterogeneous and cannot be captured by unidimensional classifications. Research and clinical practice often rely on verbal/non-verbal or speaking/non-speaking labels, but these categories, when used in isolation, obscure distinct linguistic profiles. Spoken language is also frequently used as a proxy for structural language skills, despite evidence that speech may not be generative or productive. A multidimensional perspective is therefore needed to determine whether verbal skills, spoken output, and linguistic generativity reflect dissociable aspects of language in autism, and whether variation across these dimensions can be explained by non-verbal cognition or autism characteristics. Participants were 167 autistic children aged 2?6?years from the Dutch- and French-speaking regions of Belgium. Verbal skills were assessed using standardized tests. Speaking status was quantified as the proportion of linguistic segments in spontaneous productions recorded at home. Generativity was measured using a similarity index derived from semantic embeddings. Associations with non-verbal Intelligence Quotient (IQ) and autism characteristics were examined using age-controlled linear models. Overlap between the three dimensions, Verbal, Speaking, and Generativity, was only partial. Some children with little or no speech showed relatively strong structural language abilities, whereas others produced abundant but non-generative speech and had limited structural skills. Both non-verbal IQ and autism characteristics were related to all three dimensions, with IQ explaining a larger proportion of variance. Overall, one-dimensional labels fail to capture language variability in autism; assessing Verbal, Speaking, and Generativity as complementary dimensions may better identify uneven linguistic profiles in autistic children. En ligne : https://doi.org/10.1002/aur.70324 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Defining Language Profiles in Young Autistic Children Across Verbal, Speaking, and Generative Dimensions [texte imprimé] / Federica BECCARIA, Auteur ; Liesl LEENEN, Auteur ; Marie KOLENBERG, Auteur ; Klaartje VERTONGEN, Auteur ; Ellen DEMURIE, Auteur ; Marielle WEYLAND, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur ; Ilse NOENS, Auteur ; L. A. S. Consortium BE, Auteur ; Inge ZINK, Auteur ; Mikhail KISSINE, Auteur . - p. e70324. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70324 Mots-clés : at-home recordings  autism  language development  language generativity  spoken production  verbal skills Index. décimale : PER Périodiques Résumé : ABSTRACT Language trajectories in autism are highly heterogeneous and cannot be captured by unidimensional classifications. Research and clinical practice often rely on verbal/non-verbal or speaking/non-speaking labels, but these categories, when used in isolation, obscure distinct linguistic profiles. Spoken language is also frequently used as a proxy for structural language skills, despite evidence that speech may not be generative or productive. A multidimensional perspective is therefore needed to determine whether verbal skills, spoken output, and linguistic generativity reflect dissociable aspects of language in autism, and whether variation across these dimensions can be explained by non-verbal cognition or autism characteristics. Participants were 167 autistic children aged 2?6?years from the Dutch- and French-speaking regions of Belgium. Verbal skills were assessed using standardized tests. Speaking status was quantified as the proportion of linguistic segments in spontaneous productions recorded at home. Generativity was measured using a similarity index derived from semantic embeddings. Associations with non-verbal Intelligence Quotient (IQ) and autism characteristics were examined using age-controlled linear models. Overlap between the three dimensions, Verbal, Speaking, and Generativity, was only partial. Some children with little or no speech showed relatively strong structural language abilities, whereas others produced abundant but non-generative speech and had limited structural skills. Both non-verbal IQ and autism characteristics were related to all three dimensions, with IQ explaining a larger proportion of variance. Overall, one-dimensional labels fail to capture language variability in autism; assessing Verbal, Speaking, and Generativity as complementary dimensions may better identify uneven linguistic profiles in autistic children. En ligne : https://doi.org/10.1002/aur.70324 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Defining and Measuring Developmental Regression During Childhood: A Scoping Review / Kirsten FURLEY in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70325 Titre : Defining and Measuring Developmental Regression During Childhood: A Scoping Review Type de document : texte imprimé Auteurs : Kirsten FURLEY, Auteur ; Jenny FAIRTHORNE, Auteur ; Vishnu Priya Mohanakumar SINDHU, Auteur ; Katrina WILLIAMS, Auteur ; Amanda BRIGNELL, Auteur Article en page(s) : p. e70325 Langues : Anglais (eng) Mots-clés : child development disorders  definition  developmental disabilities  developmental regression  neurodevelopmental disorders  pervasive Index. décimale : PER Périodiques Résumé : ABSTRACT Developmental regression during childhood is inconsistently defined and measured, resulting in delayed diagnostic discovery and intervention. This study aimed to examine published definitions and measures for developmental regression. A comprehensive search strategy was applied to Medline, Embase, Cochrane, and PsycINFO databases. Reviewers independently screened relevant studies according to the Preferred Reporting Items for Systematic reviews. The number and percentages of definition use, their primary features, and measures were reported. Of 19,099 potential publications, 157 were included. Thematic analysis identified four condition groups: Neurodevelopmental disorders (n?=?118); Progressive neurodegenerative conditions (n?=?17); Developmental epileptic encephalopathies (n?=?8); and Genetic conditions (n?=?14). Most studies (n?=?124, 79.0%) used an operational definition, and most specified types of skills lost (n?=?147, 93.6%). Age of onset was specified in 67.5% (n?=?106), and duration was specified in 34.4% (n?=?54). Measures designed to specifically assess developmental regression were infrequently used (n?=?5, 3.2%). We concluded that developmental regression is inconsistently defined and measured. A consistent approach is vital to ensure that all children are identified as early as possible. This will allow timely diagnostic discovery, enhance research rigor, and promote the collaboration that is needed to advance our understanding of causal mechanisms and effective interventions for affected children and their families. En ligne : https://doi.org/10.1002/aur.70325 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Defining and Measuring Developmental Regression During Childhood: A Scoping Review [texte imprimé] / Kirsten FURLEY, Auteur ; Jenny FAIRTHORNE, Auteur ; Vishnu Priya Mohanakumar SINDHU, Auteur ; Katrina WILLIAMS, Auteur ; Amanda BRIGNELL, Auteur . - p. e70325. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70325 Mots-clés : child development disorders  definition  developmental disabilities  developmental regression  neurodevelopmental disorders  pervasive Index. décimale : PER Périodiques Résumé : ABSTRACT Developmental regression during childhood is inconsistently defined and measured, resulting in delayed diagnostic discovery and intervention. This study aimed to examine published definitions and measures for developmental regression. A comprehensive search strategy was applied to Medline, Embase, Cochrane, and PsycINFO databases. Reviewers independently screened relevant studies according to the Preferred Reporting Items for Systematic reviews. The number and percentages of definition use, their primary features, and measures were reported. Of 19,099 potential publications, 157 were included. Thematic analysis identified four condition groups: Neurodevelopmental disorders (n?=?118); Progressive neurodegenerative conditions (n?=?17); Developmental epileptic encephalopathies (n?=?8); and Genetic conditions (n?=?14). Most studies (n?=?124, 79.0%) used an operational definition, and most specified types of skills lost (n?=?147, 93.6%). Age of onset was specified in 67.5% (n?=?106), and duration was specified in 34.4% (n?=?54). Measures designed to specifically assess developmental regression were infrequently used (n?=?5, 3.2%). We concluded that developmental regression is inconsistently defined and measured. A consistent approach is vital to ensure that all children are identified as early as possible. This will allow timely diagnostic discovery, enhance research rigor, and promote the collaboration that is needed to advance our understanding of causal mechanisms and effective interventions for affected children and their families. En ligne : https://doi.org/10.1002/aur.70325 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Sleep in Young Children With Autism, ADHD and Combined Presentations / Eva-Maria KURZ in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70326 Titre : Sleep in Young Children With Autism, ADHD and Combined Presentations Type de document : texte imprimé Auteurs : Eva-Maria KURZ, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur Article en page(s) : p. e70326 Langues : Anglais (eng) Mots-clés : ADHD  AuDHD  autism  sleep  transdiagnostic Index. décimale : PER Périodiques Résumé : ABSTRACT Autism and attention deficit hyperactivity disorder (ADHD) are often accompanied by sleep problems. Longitudinal studies hint towards a greater proportion of persisting sleep problems across early development in neurodivergent compared to neurotypical individuals. Within the context of a prospective infant sibling study of autism and ADHD (n?=?209), we compared early caregiver-rated sleep trajectories of individuals diagnosed with autism, ADHD or cooccurring autism and ADHD (AuDHD) at 36?months with two groups that did not meet diagnostic criteria?one group of individuals with and one without elevated likelihood of autism and/or ADHD. Sleep behaviors assessed at 10 and 14?months (i.e., number of night awakenings and settle durations) did not differ between individuals with and without a diagnosis of autism and/or ADHD. At 24 and 36?months, individuals diagnosed with autism and/or ADHD took longer to fall asleep, had less sufficient sleep, more parasomnia-related behaviors and had greater overall sleep disturbance than those without a diagnosis, suggesting that their sleep problems are more circumscribed than often reported for older age ranges. In autism specifically, bedtime resistance improved from 24 to 36?months. While additional studies incorporating objective sleep measures are needed, the current results indicate that sleep involvement in neurodevelopmental conditions may mainly reflect transdiagnostic rather than diagnosis-specific processes in early childhood. En ligne : https://doi.org/10.1002/aur.70326 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Sleep in Young Children With Autism, ADHD and Combined Presentations [texte imprimé] / Eva-Maria KURZ, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur . - p. e70326. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70326 Mots-clés : ADHD  AuDHD  autism  sleep  transdiagnostic Index. décimale : PER Périodiques Résumé : ABSTRACT Autism and attention deficit hyperactivity disorder (ADHD) are often accompanied by sleep problems. Longitudinal studies hint towards a greater proportion of persisting sleep problems across early development in neurodivergent compared to neurotypical individuals. Within the context of a prospective infant sibling study of autism and ADHD (n?=?209), we compared early caregiver-rated sleep trajectories of individuals diagnosed with autism, ADHD or cooccurring autism and ADHD (AuDHD) at 36?months with two groups that did not meet diagnostic criteria?one group of individuals with and one without elevated likelihood of autism and/or ADHD. Sleep behaviors assessed at 10 and 14?months (i.e., number of night awakenings and settle durations) did not differ between individuals with and without a diagnosis of autism and/or ADHD. At 24 and 36?months, individuals diagnosed with autism and/or ADHD took longer to fall asleep, had less sufficient sleep, more parasomnia-related behaviors and had greater overall sleep disturbance than those without a diagnosis, suggesting that their sleep problems are more circumscribed than often reported for older age ranges. In autism specifically, bedtime resistance improved from 24 to 36?months. While additional studies incorporating objective sleep measures are needed, the current results indicate that sleep involvement in neurodevelopmental conditions may mainly reflect transdiagnostic rather than diagnosis-specific processes in early childhood. En ligne : https://doi.org/10.1002/aur.70326 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Adaptive Functioning, Sensory Processing, and Behavioral Problems in Autistic Children: The Moderating Role of Gender / Cory SHULMAN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70327 Titre : Adaptive Functioning, Sensory Processing, and Behavioral Problems in Autistic Children: The Moderating Role of Gender Type de document : texte imprimé Auteurs : Cory SHULMAN, Auteur ; Danielle BITTON, Auteur ; Zili NIR, Auteur Article en page(s) : p. e70327 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently experience elevated emotional and behavioral difficulties, yet factors associated with variability remain incompletely understood. Adaptive functioning and sensory processing differences have been linked to behavioral problems, but little is known about whether associations differ between boys and girls. This study examined relationships between adaptive functioning, sensory processing, and behavioral problems in children with ASD, focusing on gender as a moderator. The purposive sampling included 110 autistic children (M age?=?85.61?months, SD?=?31.51; 50 boys and 60 girls) and their primary caregivers. Adaptive functioning was assessed using the Vineland Adaptive Behavior Scales?Third Edition, sensory processing using the Short Sensory Profile, and behavioral problems using the C hild Behavior Checklist. Gender differences were examined with Mann?Whitney tests, associations with Spearman's correlations, and moderation analyses using PROCESS with bootstrap resampling. Girls demonstrated higher internalizing and externalizing behavioral problems than boys, whereas boys showed greater sensory processing differences. Correlational analyses revealed distinct patterns: adaptive functioning showed stronger associations with behavioral difficulties among girls, whereas sensory processing differences were associated with behavioral problems among boys. Moderation analyses indicated that gender moderated the relationship between adaptive functioning and behavioral problems, such that higher adaptive functioning was associated with fewer behavioral difficulties among girls but not boys. These findings highlight gender-specific patterns in associations between functional abilities and behavior profiles in autism, underscoring the importance of considering gender in developmental pathways and intervention approaches. En ligne : https://doi.org/10.1002/aur.70327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Adaptive Functioning, Sensory Processing, and Behavioral Problems in Autistic Children: The Moderating Role of Gender [texte imprimé] / Cory SHULMAN, Auteur ; Danielle BITTON, Auteur ; Zili NIR, Auteur . - p. e70327. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70327 Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently experience elevated emotional and behavioral difficulties, yet factors associated with variability remain incompletely understood. Adaptive functioning and sensory processing differences have been linked to behavioral problems, but little is known about whether associations differ between boys and girls. This study examined relationships between adaptive functioning, sensory processing, and behavioral problems in children with ASD, focusing on gender as a moderator. The purposive sampling included 110 autistic children (M age?=?85.61?months, SD?=?31.51; 50 boys and 60 girls) and their primary caregivers. Adaptive functioning was assessed using the Vineland Adaptive Behavior Scales?Third Edition, sensory processing using the Short Sensory Profile, and behavioral problems using the C hild Behavior Checklist. Gender differences were examined with Mann?Whitney tests, associations with Spearman's correlations, and moderation analyses using PROCESS with bootstrap resampling. Girls demonstrated higher internalizing and externalizing behavioral problems than boys, whereas boys showed greater sensory processing differences. Correlational analyses revealed distinct patterns: adaptive functioning showed stronger associations with behavioral difficulties among girls, whereas sensory processing differences were associated with behavioral problems among boys. Moderation analyses indicated that gender moderated the relationship between adaptive functioning and behavioral problems, such that higher adaptive functioning was associated with fewer behavioral difficulties among girls but not boys. These findings highlight gender-specific patterns in associations between functional abilities and behavior profiles in autism, underscoring the importance of considering gender in developmental pathways and intervention approaches. En ligne : https://doi.org/10.1002/aur.70327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes / I. ILARIDOU in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70329 Titre : Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes Type de document : texte imprimé Auteurs : I. ILARIDOU, Auteur ; N. KOJOVIC, Auteur ; T. CHATAING, Auteur ; K. LATRÈCHE, Auteur ; F. JOURNAL, Auteur ; S. AKHAVAN, Auteur ; C. SANDINI, Auteur ; M. SCHAER, Auteur Article en page(s) : p. e70329 Langues : Anglais (eng) Mots-clés : autism  ESDM  heterogeneity  outcome  predictors  trajectory Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is a highly heterogenous neurodevelopmental condition that can significantly compromise the quality of life. For children showing atypical trajectories of development in their early years, early and intensive intervention has shown promise in enhancing the development of language, cognition, and social skills. Yet, marked variability in intervention response remains insufficiently understood. Characterizing this heterogeneity is essential for informing intervention strategies tailored to each child's developmental profile. The aim of the present work was to identify subgroups based on intervention response trajectories and investigate subgroup-specific predictors of intervention outcomes. We analyzed longitudinal data from 125 children (15.2?42.0?months) receiving the Early Start Denver Model (ESDM) intervention over an average follow-up period of 2?years (mean?=?1.93?±?0.25). Children gained an average of 17 points in Developmental Quotient (DQ), showed significant improvement in their adaptive skills and exhibited diminution of autism features. Using K-means clustering, we identified 3 subgroups: Progressive Group A (PrGA; 36%), which had the highest baseline cognitive scores (82.3) and gained 17 DQ points in average throughout the intervention; Progressive Group B (PrGB; 41.6%), which showed significant developmental delay at baseline (mean DQ?=?56.3) and gained 30 DQ points; and the Persistent Support Needs Group (PSNG; 22.4%), which also started in the range of delay (mean DQ?=?47.7) and remained in this range throughout intervention (mean DQ?=?41.1). Subgroup-specific analysis revealed distinct patterns of baseline factors, including stronger adaptive skills and fewer autism features, associated with a higher cognitive outcome for PrGA and PrGB. Comparison of PrGB and PSNG further identified factors distinguishing children with similar levels of cognitive delay at baseline who nevertheless followed markedly different developmental trajectories. Lower levels of repetitive and restricted behaviors, stronger adaptive functioning, and greater cumulative intervention exposure characterized the PrGB group, suggesting that both child-related and intervention-related factors may contribute to variability in developmental outcomes. En ligne : https://doi.org/10.1002/aur.70329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes [texte imprimé] / I. ILARIDOU, Auteur ; N. KOJOVIC, Auteur ; T. CHATAING, Auteur ; K. LATRÈCHE, Auteur ; F. JOURNAL, Auteur ; S. AKHAVAN, Auteur ; C. SANDINI, Auteur ; M. SCHAER, Auteur . - p. e70329. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70329 Mots-clés : autism  ESDM  heterogeneity  outcome  predictors  trajectory Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is a highly heterogenous neurodevelopmental condition that can significantly compromise the quality of life. For children showing atypical trajectories of development in their early years, early and intensive intervention has shown promise in enhancing the development of language, cognition, and social skills. Yet, marked variability in intervention response remains insufficiently understood. Characterizing this heterogeneity is essential for informing intervention strategies tailored to each child's developmental profile. The aim of the present work was to identify subgroups based on intervention response trajectories and investigate subgroup-specific predictors of intervention outcomes. We analyzed longitudinal data from 125 children (15.2?42.0?months) receiving the Early Start Denver Model (ESDM) intervention over an average follow-up period of 2?years (mean?=?1.93?±?0.25). Children gained an average of 17 points in Developmental Quotient (DQ), showed significant improvement in their adaptive skills and exhibited diminution of autism features. Using K-means clustering, we identified 3 subgroups: Progressive Group A (PrGA; 36%), which had the highest baseline cognitive scores (82.3) and gained 17 DQ points in average throughout the intervention; Progressive Group B (PrGB; 41.6%), which showed significant developmental delay at baseline (mean DQ?=?56.3) and gained 30 DQ points; and the Persistent Support Needs Group (PSNG; 22.4%), which also started in the range of delay (mean DQ?=?47.7) and remained in this range throughout intervention (mean DQ?=?41.1). Subgroup-specific analysis revealed distinct patterns of baseline factors, including stronger adaptive skills and fewer autism features, associated with a higher cognitive outcome for PrGA and PrGB. Comparison of PrGB and PSNG further identified factors distinguishing children with similar levels of cognitive delay at baseline who nevertheless followed markedly different developmental trajectories. Lower levels of repetitive and restricted behaviors, stronger adaptive functioning, and greater cumulative intervention exposure characterized the PrGB group, suggesting that both child-related and intervention-related factors may contribute to variability in developmental outcomes. En ligne : https://doi.org/10.1002/aur.70329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task-Evoked Pupillary Responses / Zainab NAARAN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70332 Titre : Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task-Evoked Pupillary Responses Type de document : texte imprimé Auteurs : Zainab NAARAN, Auteur ; Amit YASHAR, Auteur Article en page(s) : p. e70332 Langues : Anglais (eng) Mots-clés : attention allocation  autism spectrum disorder  intertrial repetition effect  task-evoked pupillary response  visual search Index. décimale : PER Périodiques Résumé : ABSTRACT According to prevalent views, autistic individuals have a stronger tendency to allocate attention to details, as supported by reports of enhanced visual search performance. However, both the dynamics and the types of information involved in attentional guidance in autism are not fully understood. We addressed this issue by testing the influence of search history on visual search performance and pupil size in a long search display (Experiment 1) and on accuracy in a brief and masked?more attentionally demanding?search display (Experiment 2). Autistic (N?=?48) and non-autistic (N?=?45) participants searched for a color singleton target (all equiluminant colors) and responded by identifying its shape. In each trial, the target and distractor colors could be repeated, switched, or novel with respect to the previous trial. In Experiment 1, while overall reaction time was comparable across groups, the task-evoked pupillary responses (TEPRs) were smaller in the autistic group, indicating reduced attentional effort in autism. In Experiment 2, in a more attentionally demanding display, autistic individuals showed superior search accuracy. In both experiments, both groups showed a reliable effect of recent search history on performance, indicating that, similar to non-autistic individuals, autistic individuals rely on recent experience during attentional allocation. Alterations in attentional allocation and its interaction with recent experience in autism were reflected in pupil responses. These alterations may provide a sensitive marker of differences in the dynamics of attentional allocation in autism, which are reflected in behavioral measurements when display conditions are more attentionally demanding. En ligne : https://doi.org/10.1002/aur.70332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task-Evoked Pupillary Responses [texte imprimé] / Zainab NAARAN, Auteur ; Amit YASHAR, Auteur . - p. e70332. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70332 Mots-clés : attention allocation  autism spectrum disorder  intertrial repetition effect  task-evoked pupillary response  visual search Index. décimale : PER Périodiques Résumé : ABSTRACT According to prevalent views, autistic individuals have a stronger tendency to allocate attention to details, as supported by reports of enhanced visual search performance. However, both the dynamics and the types of information involved in attentional guidance in autism are not fully understood. We addressed this issue by testing the influence of search history on visual search performance and pupil size in a long search display (Experiment 1) and on accuracy in a brief and masked?more attentionally demanding?search display (Experiment 2). Autistic (N?=?48) and non-autistic (N?=?45) participants searched for a color singleton target (all equiluminant colors) and responded by identifying its shape. In each trial, the target and distractor colors could be repeated, switched, or novel with respect to the previous trial. In Experiment 1, while overall reaction time was comparable across groups, the task-evoked pupillary responses (TEPRs) were smaller in the autistic group, indicating reduced attentional effort in autism. In Experiment 2, in a more attentionally demanding display, autistic individuals showed superior search accuracy. In both experiments, both groups showed a reliable effect of recent search history on performance, indicating that, similar to non-autistic individuals, autistic individuals rely on recent experience during attentional allocation. Alterations in attentional allocation and its interaction with recent experience in autism were reflected in pupil responses. These alterations may provide a sensitive marker of differences in the dynamics of attentional allocation in autism, which are reflected in behavioral measurements when display conditions are more attentionally demanding. En ligne : https://doi.org/10.1002/aur.70332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Transcriptomic Profiling of the Amygdala of Children With Autism Spectrum Disorder / Jobin BABU in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70333 Titre : Transcriptomic Profiling of the Amygdala of Children With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Jobin BABU, Auteur ; Ayushi LAL, Auteur ; Lavanya CHALLAGUNDLA, Auteur ; Obie ALLEN IV, Auteur ; Madeline GRIFFIN, Auteur ; Barbara GISABELLA, Auteur ; Harry PANTAZOPOULOS, Auteur Article en page(s) : p. e70333 Langues : Anglais (eng) Mots-clés : amygdala  autism spectrum disorders  development  extracellular matrix  immune response  synaptic signaling Index. décimale : PER Périodiques Résumé : ABSTRACT A growing number of studies point to a key role of the amygdala in Autism Spectrum Disorders (ASD). The amygdala is involved in several processes in ASD including emotional valence, facial recognition, regulation of social learning, empathy, and anxiety. Brain imaging and postmortem studies demonstrate altered amygdala development in children with ASD, associated with impairment in social behavior and anxiety. There is limited information regarding the molecular pathology of the amygdala in children with ASD. We conducted RNAseq profiling on postmortem amygdala samples from male children (4?14?years old) with ASD (n?=?8) and normotypic male children (n?=?6). Furthermore, we conducted drug repurposing analysis to identify compounds predicted to reverse the transcriptomic signatures identified in order to identify potential therapeutic targets for development of early intervention treatments. Full transcriptome gene expression profiling implicated molecular pathways involved in neuroimmune signaling, glycogen and carbohydrate metabolism, matrix metalloproteases, neurodevelopment, estrogen receptor signaling, and synaptic signaling. Targeted pathway analysis of the top 10% of genes ranked by log2 fold change implicated pathways involved in extracellular matrix organization (ECM), immune signaling, and synaptic signaling. Our drug repurposing analysis identified sleep modifying compounds and anti-inflammatory compounds including COX2 and GSK3 inhibitors amongst the top predicted therapeutic compounds. PDGF receptor tyrosine kinase inhibitors were identified as a top potential therapeutic mechanism of action. Collectively, we identified alterations in immune signaling, ECM, and synaptic signaling in the amygdala of children with ASD. Furthermore, our findings highlight a number of potential therapeutic drug targets for development of early intervention strategies. En ligne : https://doi.org/10.1002/aur.70333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Transcriptomic Profiling of the Amygdala of Children With Autism Spectrum Disorder [texte imprimé] / Jobin BABU, Auteur ; Ayushi LAL, Auteur ; Lavanya CHALLAGUNDLA, Auteur ; Obie ALLEN IV, Auteur ; Madeline GRIFFIN, Auteur ; Barbara GISABELLA, Auteur ; Harry PANTAZOPOULOS, Auteur . - p. e70333. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70333 Mots-clés : amygdala  autism spectrum disorders  development  extracellular matrix  immune response  synaptic signaling Index. décimale : PER Périodiques Résumé : ABSTRACT A growing number of studies point to a key role of the amygdala in Autism Spectrum Disorders (ASD). The amygdala is involved in several processes in ASD including emotional valence, facial recognition, regulation of social learning, empathy, and anxiety. Brain imaging and postmortem studies demonstrate altered amygdala development in children with ASD, associated with impairment in social behavior and anxiety. There is limited information regarding the molecular pathology of the amygdala in children with ASD. We conducted RNAseq profiling on postmortem amygdala samples from male children (4?14?years old) with ASD (n?=?8) and normotypic male children (n?=?6). Furthermore, we conducted drug repurposing analysis to identify compounds predicted to reverse the transcriptomic signatures identified in order to identify potential therapeutic targets for development of early intervention treatments. Full transcriptome gene expression profiling implicated molecular pathways involved in neuroimmune signaling, glycogen and carbohydrate metabolism, matrix metalloproteases, neurodevelopment, estrogen receptor signaling, and synaptic signaling. Targeted pathway analysis of the top 10% of genes ranked by log2 fold change implicated pathways involved in extracellular matrix organization (ECM), immune signaling, and synaptic signaling. Our drug repurposing analysis identified sleep modifying compounds and anti-inflammatory compounds including COX2 and GSK3 inhibitors amongst the top predicted therapeutic compounds. PDGF receptor tyrosine kinase inhibitors were identified as a top potential therapeutic mechanism of action. Collectively, we identified alterations in immune signaling, ECM, and synaptic signaling in the amygdala of children with ASD. Furthermore, our findings highlight a number of potential therapeutic drug targets for development of early intervention strategies. En ligne : https://doi.org/10.1002/aur.70333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

The Effect of Online Parent Training With and Without Coaching Support on the Well-Being of Families of Children With Neurodisabilities: A Randomized Controlled Trial / Jeffrey MCCROSSIN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70334 Titre : The Effect of Online Parent Training With and Without Coaching Support on the Well-Being of Families of Children With Neurodisabilities: A Randomized Controlled Trial Type de document : texte imprimé Auteurs : Jeffrey MCCROSSIN, Auteur ; Ali FILALI-MOUHIM, Auteur ; Michael UNGAR, Auteur ; Karen MCEWAN, Auteur ; Kathleen O'GRADY, Auteur ; Donna THOMSON, Auteur ; PARENT ADVISORY GROUP, Auteur ; Patricia LINGLEY-POTTIE, Auteur ; Patrick MCGRATH, Auteur ; Lucyna M. LACH, Auteur Article en page(s) : p. e70334 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  coaching support  family resilience  family well-being  neurodisabilities  online intervention  parent training  randomized controlled trial Index. décimale : PER Périodiques Résumé : ABSTRACT Families of children with neurodisabilities often face significant child behavioral challenges that can affect overall family functioning and well-being. This randomized controlled trial (RCT) used family resilience theory as the investigative framework to examine the impact of an online parenting program designed to address child behavioral challenges. Parents of children with a range of neurodisabilities were randomized into three groups: a self-directed online parenting program, the same program with coaching support, and a control group. Family well-being was measured using the SCORE-15 at baseline, 5, and 10?months. The primary analysis included a per-protocol sample comprising self-directed participants who completed ≥?8 of 12 modules, coached participants who completed ≥?8 modules and ≥?8 coaching sessions, and all control-group participants. Linear mixed models (LMMs) were used to analyze the repeated measures data, followed by standard linear regression models to assess the average intervention effect at each time point. Clinically significant changes were calculated via the reliable change index (RCI). Of the 454 families randomized, 422 participants had at least one available SCORE-15 assessment (self-directed: n?=?140; coached: n?=?139; control: n?=?143). Descriptively, mean SCORE-15 scores remained relatively stable in both intervention groups but increased over time in the control group (lower scores indicate better family functioning). Broader results from the full-sample analysis are reported separately (publication forthcoming). The present analyses focus on the 248 participants who met the per-protocol adherence criteria (self-directed: n?=?36; coached: n?=?60; control: n?=?152). Families that reported higher baseline family well-being were associated with greater adherence to the intervention. Participants in both intervention groups demonstrated significant improvements in family well-being relative to the control group. The coached version of the intervention demonstrated a more robust and persistent impact relative to the self-directed version, particularly with respect to communication-related subscales. Across both versions of the intervention 10%?28% of participants experienced reliable clinical change. The findings from our analysis suggest that both versions of the parenting program led to notable enhancements in aspects of family well-being, with the coached group exhibiting particularly remarkable improvements. Our study highlights that parenting interventions can contribute to the well-being of the entire family system, extending beyond individual child and parent outcomes typically addressed by these programs. En ligne : https://doi.org/10.1002/aur.70334 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] The Effect of Online Parent Training With and Without Coaching Support on the Well-Being of Families of Children With Neurodisabilities: A Randomized Controlled Trial [texte imprimé] / Jeffrey MCCROSSIN, Auteur ; Ali FILALI-MOUHIM, Auteur ; Michael UNGAR, Auteur ; Karen MCEWAN, Auteur ; Kathleen O'GRADY, Auteur ; Donna THOMSON, Auteur ; PARENT ADVISORY GROUP, Auteur ; Patricia LINGLEY-POTTIE, Auteur ; Patrick MCGRATH, Auteur ; Lucyna M. LACH, Auteur . - p. e70334. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70334 Mots-clés : autism spectrum disorder  coaching support  family resilience  family well-being  neurodisabilities  online intervention  parent training  randomized controlled trial Index. décimale : PER Périodiques Résumé : ABSTRACT Families of children with neurodisabilities often face significant child behavioral challenges that can affect overall family functioning and well-being. This randomized controlled trial (RCT) used family resilience theory as the investigative framework to examine the impact of an online parenting program designed to address child behavioral challenges. Parents of children with a range of neurodisabilities were randomized into three groups: a self-directed online parenting program, the same program with coaching support, and a control group. Family well-being was measured using the SCORE-15 at baseline, 5, and 10?months. The primary analysis included a per-protocol sample comprising self-directed participants who completed ≥?8 of 12 modules, coached participants who completed ≥?8 modules and ≥?8 coaching sessions, and all control-group participants. Linear mixed models (LMMs) were used to analyze the repeated measures data, followed by standard linear regression models to assess the average intervention effect at each time point. Clinically significant changes were calculated via the reliable change index (RCI). Of the 454 families randomized, 422 participants had at least one available SCORE-15 assessment (self-directed: n?=?140; coached: n?=?139; control: n?=?143). Descriptively, mean SCORE-15 scores remained relatively stable in both intervention groups but increased over time in the control group (lower scores indicate better family functioning). Broader results from the full-sample analysis are reported separately (publication forthcoming). The present analyses focus on the 248 participants who met the per-protocol adherence criteria (self-directed: n?=?36; coached: n?=?60; control: n?=?152). Families that reported higher baseline family well-being were associated with greater adherence to the intervention. Participants in both intervention groups demonstrated significant improvements in family well-being relative to the control group. The coached version of the intervention demonstrated a more robust and persistent impact relative to the self-directed version, particularly with respect to communication-related subscales. Across both versions of the intervention 10%?28% of participants experienced reliable clinical change. The findings from our analysis suggest that both versions of the parenting program led to notable enhancements in aspects of family well-being, with the coached group exhibiting particularly remarkable improvements. Our study highlights that parenting interventions can contribute to the well-being of the entire family system, extending beyond individual child and parent outcomes typically addressed by these programs. En ligne : https://doi.org/10.1002/aur.70334 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG / Daniela L. SECZON in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70335 Titre : Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG Type de document : texte imprimé Auteurs : Daniela L. SECZON, Auteur ; Kristin M. WOODARD, Auteur ; Tamar KOLODNY, Auteur ; Hannah M. REA, Auteur ; Mark PETTET, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur Article en page(s) : p. e70335 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals frequently report heightened sensitivity to visual stimuli, often described as discomfort in environments with bright or flickering lights. These experiences are hypothesized to reflect underlying differences in sensory gain or neural hyperexcitability; however, findings across studies have yielded mixed results, likely due to methodological variability. This study aimed to evaluate whether group differences in contrast-dependent neural and behavioral responses to a visual stimulus would be observed across complementary methods: psychophysics, fMRI, and EEG. Thirty-one autistic and twenty-seven non-autistic adults completed experimental sessions in which they passively viewed bilaterally presented 6?Hz counterphase flickering checkerboards at high (100%) and low (2%) contrast. Neural responses were measured using the blood oxygenation level-dependent (BOLD) signal from fMRI and steady-state visual evoked potential (SSVEP) from EEG. Contrast robustly modulated responses across experiments, eliciting higher neural responses; however, no group differences emerged in BOLD or behavioral thresholds. The only significant group difference was observed in SSVEP amplitudes, with autistic individuals showing significantly higher neural entrainment to the flickering stimulus than their non-autistic counterparts. Moreover, SSVEP amplitudes were associated with BOLD responses to the same low contrast visual stimulus, suggesting convergence between frequency-locked EEG responses and hemodynamic activity. SSVEP amplitudes were additionally associated with self-reported measures of hypersensitivity, linking heightened neural entrainment to individual differences in sensory experiences. They also showed a differential relationship with perceptual thresholds across groups. These findings show that differences between autistic and non-autistic participants were more evident in frequency-locked neural responses to periodic visual input, as measured by SSVEPs, and that these responses were meaningfully related to visual cortical BOLD activity and sensory hypersensitivity. En ligne : https://doi.org/10.1002/aur.70335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG [texte imprimé] / Daniela L. SECZON, Auteur ; Kristin M. WOODARD, Auteur ; Tamar KOLODNY, Auteur ; Hannah M. REA, Auteur ; Mark PETTET, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur . - p. e70335. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70335 Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals frequently report heightened sensitivity to visual stimuli, often described as discomfort in environments with bright or flickering lights. These experiences are hypothesized to reflect underlying differences in sensory gain or neural hyperexcitability; however, findings across studies have yielded mixed results, likely due to methodological variability. This study aimed to evaluate whether group differences in contrast-dependent neural and behavioral responses to a visual stimulus would be observed across complementary methods: psychophysics, fMRI, and EEG. Thirty-one autistic and twenty-seven non-autistic adults completed experimental sessions in which they passively viewed bilaterally presented 6?Hz counterphase flickering checkerboards at high (100%) and low (2%) contrast. Neural responses were measured using the blood oxygenation level-dependent (BOLD) signal from fMRI and steady-state visual evoked potential (SSVEP) from EEG. Contrast robustly modulated responses across experiments, eliciting higher neural responses; however, no group differences emerged in BOLD or behavioral thresholds. The only significant group difference was observed in SSVEP amplitudes, with autistic individuals showing significantly higher neural entrainment to the flickering stimulus than their non-autistic counterparts. Moreover, SSVEP amplitudes were associated with BOLD responses to the same low contrast visual stimulus, suggesting convergence between frequency-locked EEG responses and hemodynamic activity. SSVEP amplitudes were additionally associated with self-reported measures of hypersensitivity, linking heightened neural entrainment to individual differences in sensory experiences. They also showed a differential relationship with perceptual thresholds across groups. These findings show that differences between autistic and non-autistic participants were more evident in frequency-locked neural responses to periodic visual input, as measured by SSVEPs, and that these responses were meaningfully related to visual cortical BOLD activity and sensory hypersensitivity. En ligne : https://doi.org/10.1002/aur.70335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Risk of Neurodevelopmental Disorders Following the Herpesviral Infection in Preschooler Children / Li-Chi CHEN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70336 Titre : Risk of Neurodevelopmental Disorders Following the Herpesviral Infection in Preschooler Children Type de document : texte imprimé Auteurs : Li-Chi CHEN, Auteur ; Wei-Sheng HUANG, Auteur ; Ju-Wei HSU, Auteur ; Ya-Mei BAI, Auteur ; Shih-Jen TSAI, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : p. e70336 Langues : Anglais (eng) Mots-clés : ADHD  autism  children  epidemiology  human herpesviruses  Taiwan Index. décimale : PER Périodiques Résumé : ABSTRACT The associations between the herpesviral infections and neurodevelopmental disorders, including autism and attention deficit hyperactivity disorder (ADHD), remained unclear. Using the Taiwan National Health Insurance Research Database, the present study included 27,922 children En ligne : https://doi.org/10.1002/aur.70336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Risk of Neurodevelopmental Disorders Following the Herpesviral Infection in Preschooler Children [texte imprimé] / Li-Chi CHEN, Auteur ; Wei-Sheng HUANG, Auteur ; Ju-Wei HSU, Auteur ; Ya-Mei BAI, Auteur ; Shih-Jen TSAI, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - p. e70336. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70336 Mots-clés : ADHD  autism  children  epidemiology  human herpesviruses  Taiwan Index. décimale : PER Périodiques Résumé : ABSTRACT The associations between the herpesviral infections and neurodevelopmental disorders, including autism and attention deficit hyperactivity disorder (ADHD), remained unclear. Using the Taiwan National Health Insurance Research Database, the present study included 27,922 children En ligne : https://doi.org/10.1002/aur.70336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Parenting Stress, Parental Attitudes, and Parent-Reported Autism Symptoms of Children and Adolescents With Autism Spectrum Disorder: A Network Analysis and Subgroup Comparison by Severity / Ziqi WANG in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70337 Titre : Parenting Stress, Parental Attitudes, and Parent-Reported Autism Symptoms of Children and Adolescents With Autism Spectrum Disorder: A Network Analysis and Subgroup Comparison by Severity Type de document : texte imprimé Auteurs : Ziqi WANG, Auteur ; Yiming LONG, Auteur ; Heng LI, Auteur ; Phil REED, Auteur ; Xueyao MA, Auteur ; Yijun SHI, Auteur ; Lin ZHANG, Auteur Article en page(s) : p. e70337 Langues : Anglais (eng) Mots-clés : autism  network analysis  parenting stress  subgroups Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) presents substantial challenges for individuals and families, particularly through elevated parenting stress. Previous research has established that parenting stress is influenced by multiple interrelated factors, including parental attitudes toward ASD and parent-reported autism symptoms. Yet, the structural relations among these factors remain poorly understood. This study applied network analysis to delineate the interconnections among parenting stress, parental attitudes, and parent-reported autism symptoms in 997 parents of children and adolescents with ASD (aged 1?18?years). Network structures were compared across subgroups defined by mild, moderate, and severe levels of autism symptoms. Using Gaussian Graphical Models with EBICglasso, the analysis identified central and bridge nodes. In the overall network, ?Difficult Child? showed the highest node and bridge strength. Network structure, global strength, and node strength did not differ significantly across severity subgroups after correction for multiple comparisons, which is consistent with a broadly stable network organization of parenting stress across autism severity levels. Across all severity groups, ?Difficult Child? consistently emerged as the most central node, highlighting it as a potentially shared intervention-relevant target for supporting families of children with ASD across the autism severity spectrum. En ligne : https://doi.org/10.1002/aur.70337 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Parenting Stress, Parental Attitudes, and Parent-Reported Autism Symptoms of Children and Adolescents With Autism Spectrum Disorder: A Network Analysis and Subgroup Comparison by Severity [texte imprimé] / Ziqi WANG, Auteur ; Yiming LONG, Auteur ; Heng LI, Auteur ; Phil REED, Auteur ; Xueyao MA, Auteur ; Yijun SHI, Auteur ; Lin ZHANG, Auteur . - p. e70337. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70337 Mots-clés : autism  network analysis  parenting stress  subgroups Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) presents substantial challenges for individuals and families, particularly through elevated parenting stress. Previous research has established that parenting stress is influenced by multiple interrelated factors, including parental attitudes toward ASD and parent-reported autism symptoms. Yet, the structural relations among these factors remain poorly understood. This study applied network analysis to delineate the interconnections among parenting stress, parental attitudes, and parent-reported autism symptoms in 997 parents of children and adolescents with ASD (aged 1?18?years). Network structures were compared across subgroups defined by mild, moderate, and severe levels of autism symptoms. Using Gaussian Graphical Models with EBICglasso, the analysis identified central and bridge nodes. In the overall network, ?Difficult Child? showed the highest node and bridge strength. Network structure, global strength, and node strength did not differ significantly across severity subgroups after correction for multiple comparisons, which is consistent with a broadly stable network organization of parenting stress across autism severity levels. Across all severity groups, ?Difficult Child? consistently emerged as the most central node, highlighting it as a potentially shared intervention-relevant target for supporting families of children with ASD across the autism severity spectrum. En ligne : https://doi.org/10.1002/aur.70337 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Robots for Autism Therapy / Rebecca RAMNAUTH in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70338 Titre : Robots for Autism Therapy Type de document : texte imprimé Auteurs : Rebecca RAMNAUTH, Auteur ; Frederick SHIC, Auteur ; Brian SCASSELLATI, Auteur Article en page(s) : p. e70338 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  human–robot interaction  intervention  socially assistive robotics Index. décimale : PER Périodiques Résumé : ABSTRACT A growing body of work on robot-mediated therapy suggests that robots can elicit engagement and novel social behaviors among users with autism. In this narrative review, we trace the full historical arc of this field to date, from its inception in 2001 to 2024, covering 304 studies that present a robot for autism support. Early work largely consisted of short, highly structured sessions conducted in controlled laboratory or clinical environments. More recent research has shifted toward longer-term, real-world deployments in which robots operate with greater autonomy and engage users over multiple days or weeks. However, evidence for lasting and generalized benefits is still limited. The literature also remains focused primarily on children, with comparatively little research involving adults or individuals across a wider range of support needs. Despite rapid growth over these past two decades, the research remains fragmented across disciplinary boundaries, with robotics and clinical communities advancing similar goals without a cohesive, shared research framework. To address this, we offer a translational roadmap that details what interventions work, for whom, under which conditions, and why. We highlight current methodological gaps, outline key design considerations, and propose priorities for future research. En ligne : https://doi.org/10.1002/aur.70338 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Robots for Autism Therapy [texte imprimé] / Rebecca RAMNAUTH, Auteur ; Frederick SHIC, Auteur ; Brian SCASSELLATI, Auteur . - p. e70338. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70338 Mots-clés : Autism Spectrum Disorder  human–robot interaction  intervention  socially assistive robotics Index. décimale : PER Périodiques Résumé : ABSTRACT A growing body of work on robot-mediated therapy suggests that robots can elicit engagement and novel social behaviors among users with autism. In this narrative review, we trace the full historical arc of this field to date, from its inception in 2001 to 2024, covering 304 studies that present a robot for autism support. Early work largely consisted of short, highly structured sessions conducted in controlled laboratory or clinical environments. More recent research has shifted toward longer-term, real-world deployments in which robots operate with greater autonomy and engage users over multiple days or weeks. However, evidence for lasting and generalized benefits is still limited. The literature also remains focused primarily on children, with comparatively little research involving adults or individuals across a wider range of support needs. Despite rapid growth over these past two decades, the research remains fragmented across disciplinary boundaries, with robotics and clinical communities advancing similar goals without a cohesive, shared research framework. To address this, we offer a translational roadmap that details what interventions work, for whom, under which conditions, and why. We highlight current methodological gaps, outline key design considerations, and propose priorities for future research. En ligne : https://doi.org/10.1002/aur.70338 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Intact Visual Correlation Detection in Autistic Adults / Lukas VOGELSANG in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70339 Titre : Intact Visual Correlation Detection in Autistic Adults Type de document : texte imprimé Auteurs : Lukas VOGELSANG, Auteur ; Marin VOGELSANG, Auteur ; Cindy E. LI, Auteur ; Margaret KJELGAARD, Auteur ; Annie CARDINAUX, Auteur ; Charles A. NELSON, Auteur ; Pawan SINHA, Auteur Article en page(s) : p. e70339 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  coincidence detection  sensory correlations  temporal processing  visual perception Index. décimale : PER Périodiques Résumé : ABSTRACT The ability to detect recurring temporal co-occurrence, or temporal correlation, of sensory events is fundamental for organizing perceptual input into coherent representations. Although past work has revealed differences across several aspects of temporal processing in autism, it is unknown whether autistic and non-autistic individuals differ in the key computation of correlation detection. Here, we examined this question in the visual domain using an online task. A total of 143 age- and sex-matched adults (73 autistic, 70 non-autistic) viewed sequences in which three visual elements stochastically alternated between bright and dark states. Two of these were disks, and the third was a surrounding annulus. Participants indicated which of the two disks co-occurred more reliably with the annulus. Accuracy increased systematically with correlation strength in both groups, but there were no significant group differences and no negative association between performance and autistic trait scores when controlling for nonverbal IQ. These findings suggest that visual correlation detection, under the conditions tested here, is preserved in autistic adults. This points to a key aspect of temporal processing in autism that may provide a stable foundation for perceptual organization even amid challenges reported in other timing-related domains, such as higher-level temporal prediction. These results set the stage for future research to identify the mechanisms underlying both preserved and divergent temporal processes, and to translate these findings into evidence-based support that builds on the observed strengths of autistic individuals. En ligne : https://doi.org/10.1002/aur.70339 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Intact Visual Correlation Detection in Autistic Adults [texte imprimé] / Lukas VOGELSANG, Auteur ; Marin VOGELSANG, Auteur ; Cindy E. LI, Auteur ; Margaret KJELGAARD, Auteur ; Annie CARDINAUX, Auteur ; Charles A. NELSON, Auteur ; Pawan SINHA, Auteur . - p. e70339. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70339 Mots-clés : autism spectrum disorder  coincidence detection  sensory correlations  temporal processing  visual perception Index. décimale : PER Périodiques Résumé : ABSTRACT The ability to detect recurring temporal co-occurrence, or temporal correlation, of sensory events is fundamental for organizing perceptual input into coherent representations. Although past work has revealed differences across several aspects of temporal processing in autism, it is unknown whether autistic and non-autistic individuals differ in the key computation of correlation detection. Here, we examined this question in the visual domain using an online task. A total of 143 age- and sex-matched adults (73 autistic, 70 non-autistic) viewed sequences in which three visual elements stochastically alternated between bright and dark states. Two of these were disks, and the third was a surrounding annulus. Participants indicated which of the two disks co-occurred more reliably with the annulus. Accuracy increased systematically with correlation strength in both groups, but there were no significant group differences and no negative association between performance and autistic trait scores when controlling for nonverbal IQ. These findings suggest that visual correlation detection, under the conditions tested here, is preserved in autistic adults. This points to a key aspect of temporal processing in autism that may provide a stable foundation for perceptual organization even amid challenges reported in other timing-related domains, such as higher-level temporal prediction. These results set the stage for future research to identify the mechanisms underlying both preserved and divergent temporal processes, and to translate these findings into evidence-based support that builds on the observed strengths of autistic individuals. En ligne : https://doi.org/10.1002/aur.70339 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

The Structure and Individual Patterns of Emotional and Behavioral Problems in Preschool Children With Autism Spectrum Disorder: Evidence From Network and Cluster Analyses / Lijing LIN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70343 Titre : The Structure and Individual Patterns of Emotional and Behavioral Problems in Preschool Children With Autism Spectrum Disorder: Evidence From Network and Cluster Analyses Type de document : texte imprimé Auteurs : Lijing LIN, Auteur ; Bingqian GAO, Auteur ; Yanting HOU, Auteur ; Wenwen HUANG, Auteur ; Xiaosong LI, Auteur ; Ling WANG, Auteur ; Yidong SHEN, Auteur ; Jianjun OU, Auteur Article en page(s) : p. e70343 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cluster analysis  individual differences symptom networks  intervention target  symptom network comparison Index. décimale : PER Périodiques Résumé : ABSTRACT This study explored the interactions between emotional and behavioral symptoms in preschool children with autism spectrum disorder (ASD) and identified potential clinical subtypes based on these interrelationships. A total of 1886 preschool children with ASD and 285 age-matched typically developing (TD) children were assessed using the Child Behavior Checklist for ages 1.5?5. Symptom networks were estimated using the EBICglasso algorithm, and group differences were evaluated via network comparison tests. Subgroups within the ASD sample were identified using Individual Difference Symptom Networks (IDSN) with k-means clustering. The results revealed distinct network structures between the ASD and TD groups, with emotional reactivity demonstrating the highest centrality in the ASD network. Two distinct ASD subgroups (ASD-A and ASD-B) were identified, which showed significant differences from the TD group across all emotional and behavioral dimensionsin the CBCL 1.5?5. The subgroups differed significantly in overall network strength and specific edge connections, particularly between aggressive behavior and withdrawal problems. The findings indicate that emotional reactivity may play a central role in the symptom network of preschool children with ASD. The identification of two clinical subgroups with distinct symptom connectivity patterns provides valuable insights for developing more individualized and targeted intervention strategies. ASD-A subgroup points to the potential value of comprehensive early intervention programs, whereas ASD-B subgroup highlights the need for functional communication training and social engagement strategies. En ligne : https://doi.org/10.1002/aur.70343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] The Structure and Individual Patterns of Emotional and Behavioral Problems in Preschool Children With Autism Spectrum Disorder: Evidence From Network and Cluster Analyses [texte imprimé] / Lijing LIN, Auteur ; Bingqian GAO, Auteur ; Yanting HOU, Auteur ; Wenwen HUANG, Auteur ; Xiaosong LI, Auteur ; Ling WANG, Auteur ; Yidong SHEN, Auteur ; Jianjun OU, Auteur . - p. e70343. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70343 Mots-clés : autism spectrum disorder  cluster analysis  individual differences symptom networks  intervention target  symptom network comparison Index. décimale : PER Périodiques Résumé : ABSTRACT This study explored the interactions between emotional and behavioral symptoms in preschool children with autism spectrum disorder (ASD) and identified potential clinical subtypes based on these interrelationships. A total of 1886 preschool children with ASD and 285 age-matched typically developing (TD) children were assessed using the Child Behavior Checklist for ages 1.5?5. Symptom networks were estimated using the EBICglasso algorithm, and group differences were evaluated via network comparison tests. Subgroups within the ASD sample were identified using Individual Difference Symptom Networks (IDSN) with k-means clustering. The results revealed distinct network structures between the ASD and TD groups, with emotional reactivity demonstrating the highest centrality in the ASD network. Two distinct ASD subgroups (ASD-A and ASD-B) were identified, which showed significant differences from the TD group across all emotional and behavioral dimensionsin the CBCL 1.5?5. The subgroups differed significantly in overall network strength and specific edge connections, particularly between aggressive behavior and withdrawal problems. The findings indicate that emotional reactivity may play a central role in the symptom network of preschool children with ASD. The identification of two clinical subgroups with distinct symptom connectivity patterns provides valuable insights for developing more individualized and targeted intervention strategies. ASD-A subgroup points to the potential value of comprehensive early intervention programs, whereas ASD-B subgroup highlights the need for functional communication training and social engagement strategies. En ligne : https://doi.org/10.1002/aur.70343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593