Associations between ADHD and emotional problems from childhood to young adulthood: a longitudinal genetically sensitive study / Adi STERN in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1234-1242 Titre : Associations between ADHD and emotional problems from childhood to young adulthood: a longitudinal genetically sensitive study Type de document : texte imprimé Auteurs : Adi STERN, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Andrea DANESE, Auteur ; Helen L. FISHER, Auteur ; Timothy MATTHEWS, Auteur ; Guilherme V. POLANCZYK, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur Article en page(s) : p.1234-1242 Langues : Anglais (eng) Mots-clés : Attention deficit/hyperactivity disorder  anxiety  depression  development  genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is associated with emotional problems, and their co-occurrence often leads to worse outcomes. We investigated the developmental associations between ADHD and emotional problems from childhood to early adolescence and examined the genetic and environmental contributions to their developmental link. We further tested whether this developmental association remained across the transition to young adulthood. METHODS: We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a cohort of 2,232 British twins. In childhood, ADHD and emotional problems were assessed at ages 5, 7, 10 and 12 with mothers' and teachers' reports. At age 18, we used self-reported symptoms according to DSM-5 criteria for ADHD, and DSM-IV for anxiety and depression. RESULTS: Longitudinal analyses showed that earlier ADHD was associated with later emotional problems consistently across childhood. However, earlier emotional problems were not associated with later ADHD symptoms. The developmental association between ADHD and later emotional problems in childhood was entirely explained by common genetic factors. Consistent with results in childhood, earlier symptoms of ADHD were associated with later emotional problems during the transition to young adulthood. CONCLUSIONS: Our findings demonstrate that ADHD symptoms are predictors of the development of emotional problems, from childhood up to young adulthood, through shared genetic influences. Interventions targeting ADHD symptoms might prevent the development of emotional problems. Clinicians treating youth with ADHD must be aware of their risk for developing emotional problems and ought to assess, monitor and treat emotional problems alongside ADHD symptoms from childhood to adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Associations between ADHD and emotional problems from childhood to young adulthood: a longitudinal genetically sensitive study [texte imprimé] / Adi STERN, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Andrea DANESE, Auteur ; Helen L. FISHER, Auteur ; Timothy MATTHEWS, Auteur ; Guilherme V. POLANCZYK, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur . - p.1234-1242. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1234-1242 Mots-clés : Attention deficit/hyperactivity disorder  anxiety  depression  development  genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is associated with emotional problems, and their co-occurrence often leads to worse outcomes. We investigated the developmental associations between ADHD and emotional problems from childhood to early adolescence and examined the genetic and environmental contributions to their developmental link. We further tested whether this developmental association remained across the transition to young adulthood. METHODS: We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a cohort of 2,232 British twins. In childhood, ADHD and emotional problems were assessed at ages 5, 7, 10 and 12 with mothers' and teachers' reports. At age 18, we used self-reported symptoms according to DSM-5 criteria for ADHD, and DSM-IV for anxiety and depression. RESULTS: Longitudinal analyses showed that earlier ADHD was associated with later emotional problems consistently across childhood. However, earlier emotional problems were not associated with later ADHD symptoms. The developmental association between ADHD and later emotional problems in childhood was entirely explained by common genetic factors. Consistent with results in childhood, earlier symptoms of ADHD were associated with later emotional problems during the transition to young adulthood. CONCLUSIONS: Our findings demonstrate that ADHD symptoms are predictors of the development of emotional problems, from childhood up to young adulthood, through shared genetic influences. Interventions targeting ADHD symptoms might prevent the development of emotional problems. Clinicians treating youth with ADHD must be aware of their risk for developing emotional problems and ought to assess, monitor and treat emotional problems alongside ADHD symptoms from childhood to adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 / David MASON in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1684-1694 Titre : Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 Type de document : texte imprimé Auteurs : David MASON, Auteur ; Angelica RONALD, Auteur ; Antony AMBLER, Auteur ; Avshalom CASPI, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Jasmin WERTZ, Auteur ; Terrie E. MOFFITT, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1684-1694 Langues : Anglais (eng) Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45 years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (β = 0.09), facial age (β = 0.08), self- (β = -0.15), informant (β = -0.12), and interviewer-rated (β = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 [texte imprimé] / David MASON, Auteur ; Angelica RONALD, Auteur ; Antony AMBLER, Auteur ; Avshalom CASPI, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Jasmin WERTZ, Auteur ; Terrie E. MOFFITT, Auteur ; Francesca HAPPE, Auteur . - p.1684-1694. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1684-1694 Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45 years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (β = 0.09), facial age (β = 0.08), self- (β = -0.15), informant (β = -0.12), and interviewer-rated (β = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Gene-environment interplay in externalizing behavior from childhood through adulthood / Tina KRETSCHMER in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1206-1213 Titre : Gene-environment interplay in externalizing behavior from childhood through adulthood Type de document : texte imprimé Auteurs : Tina KRETSCHMER, Auteur ; Charlotte VRIJEN, Auteur ; Ilja M. NOLTE, Auteur ; Jasmin WERTZ, Auteur ; Catharina A. HARTMAN, Auteur Année de publication : 2022 Article en page(s) : p.1206-1213 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Antisocial Personality Disorder/genetics  Child  Child Behavior  Genetic Predisposition to Disease  Humans  Longitudinal Studies  Multifactorial Inheritance  Prospective Studies  Externalising disorder  family functioning  gene-environment interaction (GxE)  molecular genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Genetic and environmental influences on externalizing problems are often studied separately. Here, we extended prior work by investigating the implications of gene-environment interplay in childhood for early adult externalizing behavior. Genetic nurture would be indicated if parents' genetic predisposition for externalizing behavior operates through the family environment in predicting offspring early adult externalizing behavior. Evocative gene-environment correlation would be indicated if offspring genetic predisposition for externalizing behavior operates through child externalizing behavior in affecting the family environment and later early adult externalizing behavior. METHOD: Longitudinal data from seven waves of the TRacking Adolescents' Individual Lives Survey, a prospective cohort study of Dutch adolescents followed from age 11 to age 29 (n at baseline=2,734) were used. Child externalizing behavior was assessed using self and parent reports. Family dysfunction was assessed by parents. Early adult externalizing behavior was assessed using self-reports. Genome-wide polygenic scores for externalizing problems were constructed for mothers, fathers, and offspring. RESULTS: Offspring polygenic score and child behavior each predicted early adult externalizing problems, as did family dysfunction to a small extent. Parents' polygenic scores were not associated with offspring's early adult externalizing behavior. Indirect effect tests indicated that offspring polygenic score was associated with greater family dysfunction via child externalizing behavior (evocative gene-environment correlation) but the effect was just significant and the effect size was very small. Parents' polygenic scores did not predict family dysfunction, thus the data do not provide support for genetic nurture. CONCLUSIONS: A very small evocative gene-environment correlation was detected but effect sizes were much more pronounced for stability in externalizing behavior from childhood through early adulthood, which highlights the necessity to intervene early to prevent later problems. En ligne : http://dx.doi.org/10.1111/jcpp.13652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Gene-environment interplay in externalizing behavior from childhood through adulthood [texte imprimé] / Tina KRETSCHMER, Auteur ; Charlotte VRIJEN, Auteur ; Ilja M. NOLTE, Auteur ; Jasmin WERTZ, Auteur ; Catharina A. HARTMAN, Auteur . - 2022 . - p.1206-1213. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1206-1213 Mots-clés : Adolescent  Adult  Antisocial Personality Disorder/genetics  Child  Child Behavior  Genetic Predisposition to Disease  Humans  Longitudinal Studies  Multifactorial Inheritance  Prospective Studies  Externalising disorder  family functioning  gene-environment interaction (GxE)  molecular genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Genetic and environmental influences on externalizing problems are often studied separately. Here, we extended prior work by investigating the implications of gene-environment interplay in childhood for early adult externalizing behavior. Genetic nurture would be indicated if parents' genetic predisposition for externalizing behavior operates through the family environment in predicting offspring early adult externalizing behavior. Evocative gene-environment correlation would be indicated if offspring genetic predisposition for externalizing behavior operates through child externalizing behavior in affecting the family environment and later early adult externalizing behavior. METHOD: Longitudinal data from seven waves of the TRacking Adolescents' Individual Lives Survey, a prospective cohort study of Dutch adolescents followed from age 11 to age 29 (n at baseline=2,734) were used. Child externalizing behavior was assessed using self and parent reports. Family dysfunction was assessed by parents. Early adult externalizing behavior was assessed using self-reports. Genome-wide polygenic scores for externalizing problems were constructed for mothers, fathers, and offspring. RESULTS: Offspring polygenic score and child behavior each predicted early adult externalizing problems, as did family dysfunction to a small extent. Parents' polygenic scores were not associated with offspring's early adult externalizing behavior. Indirect effect tests indicated that offspring polygenic score was associated with greater family dysfunction via child externalizing behavior (evocative gene-environment correlation) but the effect was just significant and the effect size was very small. Parents' polygenic scores did not predict family dysfunction, thus the data do not provide support for genetic nurture. CONCLUSIONS: A very small evocative gene-environment correlation was detected but effect sizes were much more pronounced for stability in externalizing behavior from childhood through early adulthood, which highlights the necessity to intervene early to prevent later problems. En ligne : http://dx.doi.org/10.1111/jcpp.13652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Measuring adolescents' exposure to victimization: The Environmental Risk (E-Risk) Longitudinal Twin Study / Helen L. FISHER in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1399-1416 Titre : Measuring adolescents' exposure to victimization: The Environmental Risk (E-Risk) Longitudinal Twin Study Type de document : texte imprimé Auteurs : Helen L. FISHER, Auteur ; Avshalom CASPI, Auteur ; Terrie E. MOFFITT, Auteur ; Jasmin WERTZ, Auteur ; Rebecca GRAY, Auteur ; Joanne B. NEWBURY, Auteur ; Antony AMBLER, Auteur ; Helena ZAVOS, Auteur ; Andrea DANESE, Auteur ; Jonathan MILL, Auteur ; Candice L. ODGERS, Auteur ; Carmine M. PARIANTE, Auteur ; Chloe C.Y. WONG, Auteur ; Louise ARSENEAULT, Auteur Article en page(s) : p.1399-1416 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This paper presents multilevel findings on adolescents' victimization exposure from a large longitudinal cohort of twins. Data were obtained from the Environmental Risk (E-Risk) Longitudinal Twin Study, an epidemiological study of 2,232 children (1,116 twin pairs) followed to 18 years of age (with 93% retention). To assess adolescent victimization, we combined best practices in survey research on victimization with optimal approaches to measuring life stress and traumatic experiences, and introduce a reliable system for coding severity of victimization. One in three children experienced at least one type of severe victimization during adolescence (crime victimization, peer/sibling victimization, Internet/mobile phone victimization, sexual victimization, family violence, maltreatment, or neglect), and most types of victimization were more prevalent among children from low socioeconomic backgrounds. Exposure to multiple victimization types was common, as was revictimization; over half of those physically maltreated in childhood were also exposed to severe physical violence in adolescence. Biometric twin analyses revealed that environmental factors had the greatest influence on most types of victimization, while severe physical maltreatment from caregivers during adolescence was predominantly influenced by heritable factors. The findings from this study showcase how distinct levels of victimization measurement can be harmonized in large-scale studies of health and development. En ligne : http://dx.doi.org/10.1017/S0954579415000838 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Measuring adolescents' exposure to victimization: The Environmental Risk (E-Risk) Longitudinal Twin Study [texte imprimé] / Helen L. FISHER, Auteur ; Avshalom CASPI, Auteur ; Terrie E. MOFFITT, Auteur ; Jasmin WERTZ, Auteur ; Rebecca GRAY, Auteur ; Joanne B. NEWBURY, Auteur ; Antony AMBLER, Auteur ; Helena ZAVOS, Auteur ; Andrea DANESE, Auteur ; Jonathan MILL, Auteur ; Candice L. ODGERS, Auteur ; Carmine M. PARIANTE, Auteur ; Chloe C.Y. WONG, Auteur ; Louise ARSENEAULT, Auteur . - p.1399-1416. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1399-1416 Index. décimale : PER Périodiques Résumé : This paper presents multilevel findings on adolescents' victimization exposure from a large longitudinal cohort of twins. Data were obtained from the Environmental Risk (E-Risk) Longitudinal Twin Study, an epidemiological study of 2,232 children (1,116 twin pairs) followed to 18 years of age (with 93% retention). To assess adolescent victimization, we combined best practices in survey research on victimization with optimal approaches to measuring life stress and traumatic experiences, and introduce a reliable system for coding severity of victimization. One in three children experienced at least one type of severe victimization during adolescence (crime victimization, peer/sibling victimization, Internet/mobile phone victimization, sexual victimization, family violence, maltreatment, or neglect), and most types of victimization were more prevalent among children from low socioeconomic backgrounds. Exposure to multiple victimization types was common, as was revictimization; over half of those physically maltreated in childhood were also exposed to severe physical violence in adolescence. Biometric twin analyses revealed that environmental factors had the greatest influence on most types of victimization, while severe physical maltreatment from caregivers during adolescence was predominantly influenced by heritable factors. The findings from this study showcase how distinct levels of victimization measurement can be harmonized in large-scale studies of health and development. En ligne : http://dx.doi.org/10.1017/S0954579415000838 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study / Jessica AGNEW-BLAIS in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1153-1163 Titre : Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study Type de document : texte imprimé Auteurs : Jessica AGNEW-BLAIS, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Guilherme V. POLANCZYK, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Terrie E. MOFFITT, Auteur Année de publication : 2022 Article en page(s) : p.1153-1163 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Child  Female  Gene-Environment Interaction  Humans  Mothers  Parents  Risk Factors  Adhd  early life experience  family factors  genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. METHODS: Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self-report at age 12. Genome-wide ADHD polygenic risk scores (PRS) were calculated for mothers (n=880) and twins (n=1,999); of these, n=871 mothers and n=1,925 children had information on children's ADHD and household chaos. RESULTS: Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene-environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene-environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. CONCLUSIONS: Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study [texte imprimé] / Jessica AGNEW-BLAIS, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Guilherme V. POLANCZYK, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Terrie E. MOFFITT, Auteur . - 2022 . - p.1153-1163. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1153-1163 Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Child  Female  Gene-Environment Interaction  Humans  Mothers  Parents  Risk Factors  Adhd  early life experience  family factors  genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. METHODS: Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self-report at age 12. Genome-wide ADHD polygenic risk scores (PRS) were calculated for mothers (n=880) and twins (n=1,999); of these, n=871 mothers and n=1,925 children had information on children's ADHD and household chaos. RESULTS: Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene-environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene-environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. CONCLUSIONS: Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Parental monitoring and knowledge: Testing bidirectional associations with youths’ antisocial behavior / Jasmin WERTZ in Development and Psychopathology, 28-3 (August 2016)  

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A polygenic score for age-at-first-birth predicts disinhibition / Leah S. RICHMOND-RAKERD in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

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Something old, something new - can adding genomic data to family studies advance our understanding of the impact of nature and nurture on mental health? Commentary on McAdams et al. (2023) / Jasmin WERTZ in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)  

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Why some children with externalising problems develop internalising symptoms: testing two pathways in a genetically sensitive cohort study / Jasmin WERTZ in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

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