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Auteur G. DAWSON |
Documents disponibles écrits par cet auteur (20)
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Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk / E. J. JONES in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)
[article]
Titre : Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk Type de document : Texte imprimé et/ou numérique Auteurs : E. J. JONES, Auteur ; K. VENEMA, Auteur ; R. EARL, Auteur ; R. LOWY, Auteur ; K. BARNES, Auteur ; A. ESTES, Auteur ; G. DAWSON, Auteur ; S. J. WEBB, Auteur Article en page(s) : p.7 Langues : Anglais (eng) Mots-clés : Asd Event-related potential Habituation Social attention Social information processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects more than 1 % of the population and close to 20 % of prospectively studied infants with an older sibling with ASD. Although significant progress has been made in characterizing the emergence of behavioral symptoms of ASD, far less is known about the underlying disruptions to early learning. Recent models suggest that core aspects of the causal path to ASD may only be apparent in early infancy. Here, we investigated social attention in 6- and 12-month-old infants who did and did not meet criteria for ASD at 24 months using both cognitive and electrophysiological methods. We hypothesized that a reduction in attention engagement to faces would be associated with later ASD. METHODS: In a prospective longitudinal design, we used measures of both visual attention (habituation) and brain function (event-related potentials to faces and objects) at 6 and 12 months and investigated the relationship to ASD outcome at 24 months. RESULTS: High-risk infants who met criteria for ASD at 24 months showed shorter epochs of visual attention, faster but less prolonged neural activation to faces, and delayed sensitization responses (increases in looking) to faces at 6 months; these differences were less apparent at 12 months. These findings are consistent with disrupted engagement of sustained attention to social stimuli. CONCLUSIONS: These findings suggest that there may be fundamental early disruptions to attention engagement that may have cascading consequences for later social functioning. En ligne : http://dx.doi.org/10.1186/s11689-016-9139-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.7[article] Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk [Texte imprimé et/ou numérique] / E. J. JONES, Auteur ; K. VENEMA, Auteur ; R. EARL, Auteur ; R. LOWY, Auteur ; K. BARNES, Auteur ; A. ESTES, Auteur ; G. DAWSON, Auteur ; S. J. WEBB, Auteur . - p.7.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.7
Mots-clés : Asd Event-related potential Habituation Social attention Social information processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects more than 1 % of the population and close to 20 % of prospectively studied infants with an older sibling with ASD. Although significant progress has been made in characterizing the emergence of behavioral symptoms of ASD, far less is known about the underlying disruptions to early learning. Recent models suggest that core aspects of the causal path to ASD may only be apparent in early infancy. Here, we investigated social attention in 6- and 12-month-old infants who did and did not meet criteria for ASD at 24 months using both cognitive and electrophysiological methods. We hypothesized that a reduction in attention engagement to faces would be associated with later ASD. METHODS: In a prospective longitudinal design, we used measures of both visual attention (habituation) and brain function (event-related potentials to faces and objects) at 6 and 12 months and investigated the relationship to ASD outcome at 24 months. RESULTS: High-risk infants who met criteria for ASD at 24 months showed shorter epochs of visual attention, faster but less prolonged neural activation to faces, and delayed sensitization responses (increases in looking) to faces at 6 months; these differences were less apparent at 12 months. These findings are consistent with disrupted engagement of sustained attention to social stimuli. CONCLUSIONS: These findings suggest that there may be fundamental early disruptions to attention engagement that may have cascading consequences for later social functioning. En ligne : http://dx.doi.org/10.1186/s11689-016-9139-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 A scalable computational approach to assessing response to name in toddlers with autism / S. PEROCHON in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)
[article]
Titre : A scalable computational approach to assessing response to name in toddlers with autism Type de document : Texte imprimé et/ou numérique Auteurs : S. PEROCHON, Auteur ; M. DI MARTINO, Auteur ; R. E. AIELLO, Auteur ; J. BAKER, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Z. CHANG, Auteur ; S. COMPTON, Auteur ; N. DAVIS, Auteur ; B. EICHNER, Auteur ; S. ESPINOSA, Auteur ; J. FLOWERS, Auteur ; L. FRANZ, Auteur ; M. GAGLIANO, Auteur ; A. HARRIS, Auteur ; J. HOWARD, Auteur ; S. H. KOLLINS, Auteur ; E. M. PERRIN, Auteur ; P. RAJ, Auteur ; M. SPANOS, Auteur ; B. WALTER, Auteur ; G. SAPIRO, Auteur ; G. DAWSON, Auteur Article en page(s) : p.1120-1131 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder/diagnosis Child Child, Preschool Humans Infant Autism spectrum disorders assessment behavioral measures screening. Index. décimale : PER Périodiques Résumé : BACKGROUND: This study is part of a larger research program focused on developing objective, scalable tools for digital behavioral phenotyping. We evaluated whether a digital app delivered on a smartphone or tablet using computer vision analysis (CVA) can elicit and accurately measure one of the most common early autism symptoms, namely failure to respond to a name call. METHODS: During a pediatric primary care well-child visit, 910 toddlers, 17-37 months old, were administered an app on an iPhone or iPad consisting of brief movies during which the child's name was called three times by an examiner standing behind them. Thirty-seven toddlers were subsequently diagnosed with autism spectrum disorder (ASD). Name calls and children's behavior were recorded by the camera embedded in the device, and children's head turns were coded by both CVA and a human. RESULTS: CVA coding of response to name was found to be comparable to human coding. Based on CVA, children with ASD responded to their name significantly less frequently than children without ASD. CVA also revealed that children with ASD who did orient to their name exhibited a longer latency before turning their head. Combining information about both the frequency and the delay in response to name improved the ability to distinguish toddlers with and without ASD. CONCLUSIONS: A digital app delivered on an iPhone or iPad in real-world settings using computer vision analysis to quantify behavior can reliably detect a key early autism symptom-failure to respond to name. Moreover, the higher resolution offered by CVA identified a delay in head turn in toddlers with ASD who did respond to their name. Digital phenotyping is a promising methodology for early assessment of ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.13381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1120-1131[article] A scalable computational approach to assessing response to name in toddlers with autism [Texte imprimé et/ou numérique] / S. PEROCHON, Auteur ; M. DI MARTINO, Auteur ; R. E. AIELLO, Auteur ; J. BAKER, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Z. CHANG, Auteur ; S. COMPTON, Auteur ; N. DAVIS, Auteur ; B. EICHNER, Auteur ; S. ESPINOSA, Auteur ; J. FLOWERS, Auteur ; L. FRANZ, Auteur ; M. GAGLIANO, Auteur ; A. HARRIS, Auteur ; J. HOWARD, Auteur ; S. H. KOLLINS, Auteur ; E. M. PERRIN, Auteur ; P. RAJ, Auteur ; M. SPANOS, Auteur ; B. WALTER, Auteur ; G. SAPIRO, Auteur ; G. DAWSON, Auteur . - p.1120-1131.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1120-1131
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder/diagnosis Child Child, Preschool Humans Infant Autism spectrum disorders assessment behavioral measures screening. Index. décimale : PER Périodiques Résumé : BACKGROUND: This study is part of a larger research program focused on developing objective, scalable tools for digital behavioral phenotyping. We evaluated whether a digital app delivered on a smartphone or tablet using computer vision analysis (CVA) can elicit and accurately measure one of the most common early autism symptoms, namely failure to respond to a name call. METHODS: During a pediatric primary care well-child visit, 910 toddlers, 17-37 months old, were administered an app on an iPhone or iPad consisting of brief movies during which the child's name was called three times by an examiner standing behind them. Thirty-seven toddlers were subsequently diagnosed with autism spectrum disorder (ASD). Name calls and children's behavior were recorded by the camera embedded in the device, and children's head turns were coded by both CVA and a human. RESULTS: CVA coding of response to name was found to be comparable to human coding. Based on CVA, children with ASD responded to their name significantly less frequently than children without ASD. CVA also revealed that children with ASD who did orient to their name exhibited a longer latency before turning their head. Combining information about both the frequency and the delay in response to name improved the ability to distinguish toddlers with and without ASD. CONCLUSIONS: A digital app delivered on an iPhone or iPad in real-world settings using computer vision analysis to quantify behavior can reliably detect a key early autism symptom-failure to respond to name. Moreover, the higher resolution offered by CVA identified a delay in head turn in toddlers with ASD who did respond to their name. Digital phenotyping is a promising methodology for early assessment of ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.13381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Social attention: a possible early indicator of efficacy in autism clinical trials / G. DAWSON in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)
[article]
Titre : Social attention: a possible early indicator of efficacy in autism clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : G. DAWSON, Auteur ; Raphael BERNIER, Auteur ; R. H. RING, Auteur Article en page(s) : p.11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : For decades, researchers have sought to clarify the nature of the social communication impairments in autism, highlighting impaired or atypical 'social attention' as a key measurable construct that helps to define the core impairment of social communication. In this paper, we provide an overview of research on social attention impairments in autism and their relation to deficiencies in neural circuitry related to social reward. We offer a framework for considering social attention as a potential moderator or mediator of response to early behavioral intervention, and as an early indicator of efficacy of behavioral and/or pharmacological treatments aimed at addressing the social impairments in autism. En ligne : http://dx.doi.org/10.1186/1866-1955-4-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344
in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.11[article] Social attention: a possible early indicator of efficacy in autism clinical trials [Texte imprimé et/ou numérique] / G. DAWSON, Auteur ; Raphael BERNIER, Auteur ; R. H. RING, Auteur . - p.11.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.11
Index. décimale : PER Périodiques Résumé : For decades, researchers have sought to clarify the nature of the social communication impairments in autism, highlighting impaired or atypical 'social attention' as a key measurable construct that helps to define the core impairment of social communication. In this paper, we provide an overview of research on social attention impairments in autism and their relation to deficiencies in neural circuitry related to social reward. We offer a framework for considering social attention as a potential moderator or mediator of response to early behavioral intervention, and as an early indicator of efficacy of behavioral and/or pharmacological treatments aimed at addressing the social impairments in autism. En ligne : http://dx.doi.org/10.1186/1866-1955-4-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 Visual Exploration in Autism Spectrum Disorder: Exploring Age Differences and Dynamic Features Using Recurrence Quantification Analysis / N. V. MANYAKOV in Autism Research, 11-11 (November 2018)
[article]
Titre : Visual Exploration in Autism Spectrum Disorder: Exploring Age Differences and Dynamic Features Using Recurrence Quantification Analysis Type de document : Texte imprimé et/ou numérique Auteurs : N. V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; L. MASON, Auteur ; S. NESS, Auteur ; D. LEWIN, Auteur ; A. SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; M. S. GOODWIN, Auteur ; G. DAWSON, Auteur ; R. HENDREN, Auteur ; B. LEVENTHAL, Auteur ; F. SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : p.1554-1566 Langues : Anglais (eng) Mots-clés : *autism spectrum disorder *biomarkers *eye-tracking *recurrence quantification analysis *restricted repetitive behavior *visual exploration Index. décimale : PER Périodiques Résumé : Eye-tracking studies have demonstrated that individuals with autism spectrum disorder sometimes show differences in attention and gaze patterns. This includes preference for certain nonsocial objects, heightened attention to detail, and more difficulty with attention shifting and disengagement, which may be associated with restricted and repetitive behaviors. This study utilized a visual exploration task and replicates findings of reduced number of objects explored and increased fixation duration on high autism interest objects in a large sample of individuals with autism spectrum disorder (n = 129, age 6-54 years) in comparison with a typically developing group. These findings correlated with parent-reported repetitive behaviors. Additionally, we applied recurrent quantification analysis to enable identification of new eye-tracking features, which accounted for temporal and spatial differences in viewing patterns. These new features were found to discriminate between autism spectrum disorder and typically developing groups and were correlated with parent-reported repetitive behaviors. Original and novel eye-tracking features identified by recurrent quantification analysis differed in their relationships to reported behaviors and were dependent on age. Trial Registration: NCT02299700. Autism Research 2018, 11: 1554-1566. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using eye-tracking technology and a visual exploration task, we showed that people with autism spectrum disorder (ASD) spend more time looking at particular kinds of objects, like trains and clocks, and look at fewer objects overall than people without ASD. Where people look and the order in which they look at objects were related to the restricted and repetitive behaviors reported by parents. Eye-tracking may be a useful addition to parent reports for measuring changes in behavior in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.2021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370
in Autism Research > 11-11 (November 2018) . - p.1554-1566[article] Visual Exploration in Autism Spectrum Disorder: Exploring Age Differences and Dynamic Features Using Recurrence Quantification Analysis [Texte imprimé et/ou numérique] / N. V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; L. MASON, Auteur ; S. NESS, Auteur ; D. LEWIN, Auteur ; A. SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; M. S. GOODWIN, Auteur ; G. DAWSON, Auteur ; R. HENDREN, Auteur ; B. LEVENTHAL, Auteur ; F. SHIC, Auteur ; Gahan PANDINA, Auteur . - p.1554-1566.
Langues : Anglais (eng)
in Autism Research > 11-11 (November 2018) . - p.1554-1566
Mots-clés : *autism spectrum disorder *biomarkers *eye-tracking *recurrence quantification analysis *restricted repetitive behavior *visual exploration Index. décimale : PER Périodiques Résumé : Eye-tracking studies have demonstrated that individuals with autism spectrum disorder sometimes show differences in attention and gaze patterns. This includes preference for certain nonsocial objects, heightened attention to detail, and more difficulty with attention shifting and disengagement, which may be associated with restricted and repetitive behaviors. This study utilized a visual exploration task and replicates findings of reduced number of objects explored and increased fixation duration on high autism interest objects in a large sample of individuals with autism spectrum disorder (n = 129, age 6-54 years) in comparison with a typically developing group. These findings correlated with parent-reported repetitive behaviors. Additionally, we applied recurrent quantification analysis to enable identification of new eye-tracking features, which accounted for temporal and spatial differences in viewing patterns. These new features were found to discriminate between autism spectrum disorder and typically developing groups and were correlated with parent-reported repetitive behaviors. Original and novel eye-tracking features identified by recurrent quantification analysis differed in their relationships to reported behaviors and were dependent on age. Trial Registration: NCT02299700. Autism Research 2018, 11: 1554-1566. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using eye-tracking technology and a visual exploration task, we showed that people with autism spectrum disorder (ASD) spend more time looking at particular kinds of objects, like trains and clocks, and look at fewer objects overall than people without ASD. Where people look and the order in which they look at objects were related to the restricted and repetitive behaviors reported by parents. Eye-tracking may be a useful addition to parent reports for measuring changes in behavior in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.2021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 Visual Preference for Biological Motion in Children and Adults with Autism Spectrum Disorder: An Eye-Tracking Study / Dzmitry A. KALIUKHOVICH in Journal of Autism and Developmental Disorders, 51-7 (July 2021)