Childhood vaccination as a protective factor for developmental psychopathology / Bora KIM in Research in Autism Spectrum Disorders, 79 (November 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 79 (November 2020) . - 101653 Titre : Childhood vaccination as a protective factor for developmental psychopathology Type de document : texte imprimé Auteurs : Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Ho-Jang KWON, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Hosanna KIM, Auteur ; Patricia HONG, Auteur ; Bennett L. LEVENTHAL, Auteur Article en page(s) : 101653 Langues : Anglais (eng) Mots-clés : ASD  Developmental psychopathology  Vaccination  Protective effects Index. décimale : PER Périodiques Résumé : Backgrounds Despite multiple studies demonstrating no relationship between childhood vaccination and increasing Autism Spectrum Disorder (ASD) prevalence, parental fear for vaccination and subsequent refusal to vaccinate their children continue, resulting in recent outbreaks of childhood infections such as measles in the US. We examine the relationship between the completion of 6 recommended vaccinations in childhood and the likelihood for having developmental psychopathology. Methods Two large-scale South Korean epidemiologic samples were used to examine whether completion of childhood vaccinations decrease likelihood of having ASD as assessed by Autism Spectrum Screening Questionnaire (ASSQ) and behavioral problems scores. Parental reports on vaccination completion were categorized in groups: <3, 4−5, & 6. The primary outcome is the likelihood of having ASD and/or, internalizing, and externalizing behavioral symptoms. Likelihood of having ASD was categorized as: low (ASSQ < 10), intermediate (ASSQ = 10–14), and high (ASSQ ≥ 15). The risk for externalizing/internalizing symptoms was assessed with the Behavior Assessment System for Children-Parent Rating Scale. We examined the hypothesis in a Discovery Sample (DS) (N = 10,006) and verified findings in a Replication Sample (RS) (N = 29,381). Results 84.3 % of DS and 80.1 % of RS participants were fully vaccinated. In the DS, after adjusting for demographics and confounders, children with incomplete-vaccinations were at greater risk for ASD when compared to those fully vaccinated (adjusted odds ratio [aOR] = 1.42, 95 % Confidence Interval [CI] 1.17−1.73 with 4−5 vaccinations; aOR = 2.33, CI 1.53−3.56 with vaccination <3). The DS finding was confirmed in the RS (aOR = 1.44, CI 1.32−1.58 with 4−5 vaccinations and aOR = 2.19, CI 1.80−2.67 with < 3 vaccinations). In the DS, those with incomplete-vaccinations were at a greater risk for internalizing and externalizing symptoms. Conclusions We replicate our own and prior findings that vaccination does not increase ASD risk. Further, completing recommended vaccinations may offer protection against the risk of having ASD and other developmental psychopathology. En ligne : https://doi.org/10.1016/j.rasd.2020.101653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Childhood vaccination as a protective factor for developmental psychopathology [texte imprimé] / Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Ho-Jang KWON, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Hosanna KIM, Auteur ; Patricia HONG, Auteur ; Bennett L. LEVENTHAL, Auteur . - 101653. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101653 Mots-clés : ASD  Developmental psychopathology  Vaccination  Protective effects Index. décimale : PER Périodiques Résumé : Backgrounds Despite multiple studies demonstrating no relationship between childhood vaccination and increasing Autism Spectrum Disorder (ASD) prevalence, parental fear for vaccination and subsequent refusal to vaccinate their children continue, resulting in recent outbreaks of childhood infections such as measles in the US. We examine the relationship between the completion of 6 recommended vaccinations in childhood and the likelihood for having developmental psychopathology. Methods Two large-scale South Korean epidemiologic samples were used to examine whether completion of childhood vaccinations decrease likelihood of having ASD as assessed by Autism Spectrum Screening Questionnaire (ASSQ) and behavioral problems scores. Parental reports on vaccination completion were categorized in groups: <3, 4−5, & 6. The primary outcome is the likelihood of having ASD and/or, internalizing, and externalizing behavioral symptoms. Likelihood of having ASD was categorized as: low (ASSQ < 10), intermediate (ASSQ = 10–14), and high (ASSQ ≥ 15). The risk for externalizing/internalizing symptoms was assessed with the Behavior Assessment System for Children-Parent Rating Scale. We examined the hypothesis in a Discovery Sample (DS) (N = 10,006) and verified findings in a Replication Sample (RS) (N = 29,381). Results 84.3 % of DS and 80.1 % of RS participants were fully vaccinated. In the DS, after adjusting for demographics and confounders, children with incomplete-vaccinations were at greater risk for ASD when compared to those fully vaccinated (adjusted odds ratio [aOR] = 1.42, 95 % Confidence Interval [CI] 1.17−1.73 with 4−5 vaccinations; aOR = 2.33, CI 1.53−3.56 with vaccination <3). The DS finding was confirmed in the RS (aOR = 1.44, CI 1.32−1.58 with 4−5 vaccinations and aOR = 2.19, CI 1.80−2.67 with < 3 vaccinations). In the DS, those with incomplete-vaccinations were at a greater risk for internalizing and externalizing symptoms. Conclusions We replicate our own and prior findings that vaccination does not increase ASD risk. Further, completing recommended vaccinations may offer protection against the risk of having ASD and other developmental psychopathology. En ligne : https://doi.org/10.1016/j.rasd.2020.101653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions / Patricia SEGURA ; Louise GALLAGHER ; Stelios GEORGIADES ; Panagiota PERVANIDOU ; Audrey THURM ; Lindsay ALEXANDER ; Evdokia ANAGNOSTOU ; Yuta AOKI ; Catherine S. BIRKEN ; Somer L. BISHOP ; Jessica BOI ; Carmela BRAVACCIO ; Helena BRENTANI ; Paola CANEVINI ; Alessandra CARTA ; Alice CHARACH ; Antonella COSTANTINO ; Katherine T. COST ; Elaine A. CRAVO ; Jennifer CROSBIE ; Chiara DAVICO ; Federica DONNO ; Junya FUJINO ; Alessandra GABELLONE ; Cristiane T. GEYER ; Tomoya HIROTA ; Stephen M. KANNE ; Makiko KAWASHIMA ; Elizabeth KELLEY ; Hosanna KIM ; Young Shin KIM ; So Hyun KIM ; Daphne J. KORCZAK ; Meng-Chuan LAI ; Lucia MARGARI ; Lucia MARZULLI ; Gabriele MASI ; Luigi MAZZONE ; Jane MCGRATH ; Suneeta MONGA ; Paola MOROSINI ; Shinichiro NAKAJIMA ; Antonio NARZISI ; Rob NICOLSON ; Aki NIKOLAIDIS ; Yoshihiro NODA ; Kerri P. NOWELL ; Miriam POLIZZI ; Joana PORTOLESE ; Maria Pia RICCIO ; Manabu SAITO ; Ida SCHWARTZ ; Anish K. SIMHAL ; Martina SIRACUSANO ; Stefano SOTGIU ; Jacob STROUD ; Fernando SUMIYA ; Yoshiyuki TACHIBANA ; Nicole TAKAHASHI ; Riina TAKAHASHI ; Hiroki TAMON ; Raffaella TANCREDI ; Benedetto VITIELLO ; Alessandro ZUDDAS ; Bennett L. LEVENTHAL ; Kathleen R. MERIKANGAS ; Michael P. MILHAM ; Adriana DI MARTINO in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 7 p. Titre : CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions Type de document : texte imprimé Auteurs : Patricia SEGURA, Auteur ; Louise GALLAGHER, Auteur ; Stelios GEORGIADES, Auteur ; Panagiota PERVANIDOU, Auteur ; Audrey THURM, Auteur ; Lindsay ALEXANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Yuta AOKI, Auteur ; Catherine S. BIRKEN, Auteur ; Somer L. BISHOP, Auteur ; Jessica BOI, Auteur ; Carmela BRAVACCIO, Auteur ; Helena BRENTANI, Auteur ; Paola CANEVINI, Auteur ; Alessandra CARTA, Auteur ; Alice CHARACH, Auteur ; Antonella COSTANTINO, Auteur ; Katherine T. COST, Auteur ; Elaine A. CRAVO, Auteur ; Jennifer CROSBIE, Auteur ; Chiara DAVICO, Auteur ; Federica DONNO, Auteur ; Junya FUJINO, Auteur ; Alessandra GABELLONE, Auteur ; Cristiane T. GEYER, Auteur ; Tomoya HIROTA, Auteur ; Stephen M. KANNE, Auteur ; Makiko KAWASHIMA, Auteur ; Elizabeth KELLEY, Auteur ; Hosanna KIM, Auteur ; Young Shin KIM, Auteur ; So Hyun KIM, Auteur ; Daphne J. KORCZAK, Auteur ; Meng-Chuan LAI, Auteur ; Lucia MARGARI, Auteur ; Lucia MARZULLI, Auteur ; Gabriele MASI, Auteur ; Luigi MAZZONE, Auteur ; Jane MCGRATH, Auteur ; Suneeta MONGA, Auteur ; Paola MOROSINI, Auteur ; Shinichiro NAKAJIMA, Auteur ; Antonio NARZISI, Auteur ; Rob NICOLSON, Auteur ; Aki NIKOLAIDIS, Auteur ; Yoshihiro NODA, Auteur ; Kerri P. NOWELL, Auteur ; Miriam POLIZZI, Auteur ; Joana PORTOLESE, Auteur ; Maria Pia RICCIO, Auteur ; Manabu SAITO, Auteur ; Ida SCHWARTZ, Auteur ; Anish K. SIMHAL, Auteur ; Martina SIRACUSANO, Auteur ; Stefano SOTGIU, Auteur ; Jacob STROUD, Auteur ; Fernando SUMIYA, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Nicole TAKAHASHI, Auteur ; Riina TAKAHASHI, Auteur ; Hiroki TAMON, Auteur ; Raffaella TANCREDI, Auteur ; Benedetto VITIELLO, Auteur ; Alessandro ZUDDAS, Auteur ; Bennett L. LEVENTHAL, Auteur ; Kathleen R. MERIKANGAS, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services. METHODS: Using a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N=1275 individuals with ASD/NDD (age=11.0+3.6 years; n females=277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups. RESULTS: Clustering revealed four subgroups. One subgroup-broad symptom worsening only (20%)-included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup. LIMITATIONS: Notable limitations of the study are its cross-sectional nature and focus on the first six months of the pandemic. CONCLUSIONS: Concomitantly assessing variation in changes of symptoms and service access during the first phase of the pandemic revealed differential outcome profiles in ASD/NDD youth. Subgroups were characterized by distinct prediction patterns across a set of pre- and pandemic-related experiences/contexts. Results may inform recovery efforts and preparedness in future crises; they also underscore the critical value of international data-sharing and collaborations to address the needs of those most vulnerable in times of crisis. En ligne : http://dx.doi.org/10.1186/s13229-022-00536-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions [texte imprimé] / Patricia SEGURA, Auteur ; Louise GALLAGHER, Auteur ; Stelios GEORGIADES, Auteur ; Panagiota PERVANIDOU, Auteur ; Audrey THURM, Auteur ; Lindsay ALEXANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Yuta AOKI, Auteur ; Catherine S. BIRKEN, Auteur ; Somer L. BISHOP, Auteur ; Jessica BOI, Auteur ; Carmela BRAVACCIO, Auteur ; Helena BRENTANI, Auteur ; Paola CANEVINI, Auteur ; Alessandra CARTA, Auteur ; Alice CHARACH, Auteur ; Antonella COSTANTINO, Auteur ; Katherine T. COST, Auteur ; Elaine A. CRAVO, Auteur ; Jennifer CROSBIE, Auteur ; Chiara DAVICO, Auteur ; Federica DONNO, Auteur ; Junya FUJINO, Auteur ; Alessandra GABELLONE, Auteur ; Cristiane T. GEYER, Auteur ; Tomoya HIROTA, Auteur ; Stephen M. KANNE, Auteur ; Makiko KAWASHIMA, Auteur ; Elizabeth KELLEY, Auteur ; Hosanna KIM, Auteur ; Young Shin KIM, Auteur ; So Hyun KIM, Auteur ; Daphne J. KORCZAK, Auteur ; Meng-Chuan LAI, Auteur ; Lucia MARGARI, Auteur ; Lucia MARZULLI, Auteur ; Gabriele MASI, Auteur ; Luigi MAZZONE, Auteur ; Jane MCGRATH, Auteur ; Suneeta MONGA, Auteur ; Paola MOROSINI, Auteur ; Shinichiro NAKAJIMA, Auteur ; Antonio NARZISI, Auteur ; Rob NICOLSON, Auteur ; Aki NIKOLAIDIS, Auteur ; Yoshihiro NODA, Auteur ; Kerri P. NOWELL, Auteur ; Miriam POLIZZI, Auteur ; Joana PORTOLESE, Auteur ; Maria Pia RICCIO, Auteur ; Manabu SAITO, Auteur ; Ida SCHWARTZ, Auteur ; Anish K. SIMHAL, Auteur ; Martina SIRACUSANO, Auteur ; Stefano SOTGIU, Auteur ; Jacob STROUD, Auteur ; Fernando SUMIYA, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Nicole TAKAHASHI, Auteur ; Riina TAKAHASHI, Auteur ; Hiroki TAMON, Auteur ; Raffaella TANCREDI, Auteur ; Benedetto VITIELLO, Auteur ; Alessandro ZUDDAS, Auteur ; Bennett L. LEVENTHAL, Auteur ; Kathleen R. MERIKANGAS, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur . - 7 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 7 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services. METHODS: Using a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N=1275 individuals with ASD/NDD (age=11.0+3.6 years; n females=277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups. RESULTS: Clustering revealed four subgroups. One subgroup-broad symptom worsening only (20%)-included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup. LIMITATIONS: Notable limitations of the study are its cross-sectional nature and focus on the first six months of the pandemic. CONCLUSIONS: Concomitantly assessing variation in changes of symptoms and service access during the first phase of the pandemic revealed differential outcome profiles in ASD/NDD youth. Subgroups were characterized by distinct prediction patterns across a set of pre- and pandemic-related experiences/contexts. Results may inform recovery efforts and preparedness in future crises; they also underscore the critical value of international data-sharing and collaborations to address the needs of those most vulnerable in times of crisis. En ligne : http://dx.doi.org/10.1186/s13229-022-00536-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Improving Social Knowledge and Skills among Adolescents with Autism: Systematic Review and Meta-Analysis of UCLA PEERS® for Adolescents / Shuting ZHENG in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4488-4503 Titre : Improving Social Knowledge and Skills among Adolescents with Autism: Systematic Review and Meta-Analysis of UCLA PEERS® for Adolescents Type de document : texte imprimé Auteurs : Shuting ZHENG, Auteur ; Hosanna KIM, Auteur ; Emma SALZMAN, Auteur ; Katy ANKENMAN, Auteur ; Stephen BENT, Auteur Article en page(s) : p.4488-4503 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Humans  Peer Group  Social Skills  Adolescents  Autism  Effect sizes  Meta-analysis  Social skills training Index. décimale : PER Périodiques Résumé : UCLA PEERS® for Adolescents is a widely applied program among a number of social skills training programs developed over the years. We synthesized current research evidence on the PEERS program to evaluate the treatment effect on four commonly used outcome measures. 12 studies met inclusion criteria for the review and nine met the criteria for meta-analysis. Results showed moderate to large pooled effects across measures and informants in favor of the PEERS program, with the largest effect seen in social knowledge improvement and the smallest effect in the frequency of get-togethers. The heterogeneity of effects across studies were examined and the limitations of the current evidence were discussed. En ligne : http://dx.doi.org/10.1007/s10803-021-04885-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Improving Social Knowledge and Skills among Adolescents with Autism: Systematic Review and Meta-Analysis of UCLA PEERS® for Adolescents [texte imprimé] / Shuting ZHENG, Auteur ; Hosanna KIM, Auteur ; Emma SALZMAN, Auteur ; Katy ANKENMAN, Auteur ; Stephen BENT, Auteur . - p.4488-4503. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4488-4503 Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Humans  Peer Group  Social Skills  Adolescents  Autism  Effect sizes  Meta-analysis  Social skills training Index. décimale : PER Périodiques Résumé : UCLA PEERS® for Adolescents is a widely applied program among a number of social skills training programs developed over the years. We synthesized current research evidence on the PEERS program to evaluate the treatment effect on four commonly used outcome measures. 12 studies met inclusion criteria for the review and nine met the criteria for meta-analysis. Results showed moderate to large pooled effects across measures and informants in favor of the PEERS program, with the largest effect seen in social knowledge improvement and the smallest effect in the frequency of get-togethers. The heterogeneity of effects across studies were examined and the limitations of the current evidence were discussed. En ligne : http://dx.doi.org/10.1007/s10803-021-04885-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Overconnectivity of the right Heschl's and inferior temporal gyrus correlates with symptom severity in preschoolers with autism spectrum disorder / Daegyeom KIM in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2314-2329 Titre : Overconnectivity of the right Heschl's and inferior temporal gyrus correlates with symptom severity in preschoolers with autism spectrum disorder Type de document : texte imprimé Auteurs : Daegyeom KIM, Auteur ; Joo Young LEE, Auteur ; Byeong Chang JEONG, Auteur ; Ja-Hye AHN, Auteur ; Johanna Inhyang KIM, Auteur ; Eun Soo LEE, Auteur ; Hosanna KIM, Auteur ; Hyun Ju LEE, Auteur ; Cheol E. HAN, Auteur Article en page(s) : p.2314-2329 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Child  Child, Preschool  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  Temporal Lobe/diagnostic imaging  Heschl's gyrus  autism spectrum disorder  brain networks  diffusion tensor imaging  graph theory  overconnectivity  preschool children Index. décimale : PER Périodiques Résumé : Previous studies have reported varying findings regarding the association of brain connectivity in autism spectrum disorder (ASD) with overconnectivity, underconnectivity, or both. Despite the emerging understanding that ASD is a developmental disconnection syndrome, very little is known about structural brain networks in preschool-aged children with low-functioning ASD. We aimed to investigate the structural brain connectivity of low-functioning ASD using diffusion magnetic resonance imaging and graph theory to examine alterations in different brain network topologies and identify any correlations with the clinical severity of ASD in preschool-aged children. Fifty-two preschool-aged children (28 with ASD and 24 with typical development) were included in the analysis. Graph-based network analysis was performed to examine the global and local structural brain networks. Nodal network measures exhibited increased nodal strength in the right Heschl's gyrus, which was positively associated with all autistic clinical symptoms (Autism Diagnostic Observation Schedule and Childhood Autism Rating Scale [CARS]). The nodal strength of the right inferior temporal gyrus showed a moderate correlation with the CARS score. Using network-based statistics, we identified a subnetwork with increased connections encompassing the right Heschl's gyrus and the right inferior temporal gyrus in preschool-aged children with ASD. The asymmetric value in the inferior temporal gyrus exhibited right dominance of nodal strength in children with ASD compared to that in typically developing children. Our findings support the theory of aberrant brain growth and overconnectivity as the underlying mechanism of ASD and provides new insights into potential regional biomarkers that can detect low-functioning ASD in preschool-aged children. LAY SUMMARY: This study supports the theory of aberrant brain growth and overconnectivity as an explanation for ASD. Measuring the right HG and inferior temporal gyrus provides new insights of potential regional biomarkers underpinning ASD in preschool-aged children. En ligne : http://dx.doi.org/10.1002/aur.2609 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Overconnectivity of the right Heschl's and inferior temporal gyrus correlates with symptom severity in preschoolers with autism spectrum disorder [texte imprimé] / Daegyeom KIM, Auteur ; Joo Young LEE, Auteur ; Byeong Chang JEONG, Auteur ; Ja-Hye AHN, Auteur ; Johanna Inhyang KIM, Auteur ; Eun Soo LEE, Auteur ; Hosanna KIM, Auteur ; Hyun Ju LEE, Auteur ; Cheol E. HAN, Auteur . - p.2314-2329. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2314-2329 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Child  Child, Preschool  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  Temporal Lobe/diagnostic imaging  Heschl's gyrus  autism spectrum disorder  brain networks  diffusion tensor imaging  graph theory  overconnectivity  preschool children Index. décimale : PER Périodiques Résumé : Previous studies have reported varying findings regarding the association of brain connectivity in autism spectrum disorder (ASD) with overconnectivity, underconnectivity, or both. Despite the emerging understanding that ASD is a developmental disconnection syndrome, very little is known about structural brain networks in preschool-aged children with low-functioning ASD. We aimed to investigate the structural brain connectivity of low-functioning ASD using diffusion magnetic resonance imaging and graph theory to examine alterations in different brain network topologies and identify any correlations with the clinical severity of ASD in preschool-aged children. Fifty-two preschool-aged children (28 with ASD and 24 with typical development) were included in the analysis. Graph-based network analysis was performed to examine the global and local structural brain networks. Nodal network measures exhibited increased nodal strength in the right Heschl's gyrus, which was positively associated with all autistic clinical symptoms (Autism Diagnostic Observation Schedule and Childhood Autism Rating Scale [CARS]). The nodal strength of the right inferior temporal gyrus showed a moderate correlation with the CARS score. Using network-based statistics, we identified a subnetwork with increased connections encompassing the right Heschl's gyrus and the right inferior temporal gyrus in preschool-aged children with ASD. The asymmetric value in the inferior temporal gyrus exhibited right dominance of nodal strength in children with ASD compared to that in typically developing children. Our findings support the theory of aberrant brain growth and overconnectivity as the underlying mechanism of ASD and provides new insights into potential regional biomarkers that can detect low-functioning ASD in preschool-aged children. LAY SUMMARY: This study supports the theory of aberrant brain growth and overconnectivity as an explanation for ASD. Measuring the right HG and inferior temporal gyrus provides new insights of potential regional biomarkers underpinning ASD in preschool-aged children. En ligne : http://dx.doi.org/10.1002/aur.2609 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder / Bora KIM in Autism, 26-7 (October 2022)  

Public ISBD [article]  inAutism > 26-7 (October 2022) . - p.1946-1959 Titre : Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder Type de document : texte imprimé Auteurs : Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Shan DONG, Auteur ; Ho-Jang KWON, Auteur ; Young-Suk KIM, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Seung-Jin YOO, Auteur ; Hosanna KIM, Auteur ; Patricia S. HONG, Auteur ; Stephan J. SANDERS, Auteur ; Bennett L. LEVENTHAL, Auteur Article en page(s) : p.1946-1959 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Causality  Family  Female  Humans  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology/etiology  Risk Factors  Smoking/adverse effects  autism spectrum disorders  environmental factors  risk factor epidemiology  relation to the research presented in this manuscript. Index. décimale : PER Périodiques Résumé : What is Already Known about This Subject: Genetics, (including de novo mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention.What This Study Adds: This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk.Implications for practice, research, or policy: Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring. En ligne : http://dx.doi.org/10.1177/13623613211007319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder [texte imprimé] / Bora KIM, Auteur ; Mina HA, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Shan DONG, Auteur ; Ho-Jang KWON, Auteur ; Young-Suk KIM, Auteur ; Myung-Ho LIM, Auteur ; Ki-Chung PAIK, Auteur ; Seung-Jin YOO, Auteur ; Hosanna KIM, Auteur ; Patricia S. HONG, Auteur ; Stephan J. SANDERS, Auteur ; Bennett L. LEVENTHAL, Auteur . - p.1946-1959. Langues : Anglais (eng) in Autism > 26-7 (October 2022) . - p.1946-1959 Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Causality  Family  Female  Humans  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology/etiology  Risk Factors  Smoking/adverse effects  autism spectrum disorders  environmental factors  risk factor epidemiology  relation to the research presented in this manuscript. Index. décimale : PER Périodiques Résumé : What is Already Known about This Subject: Genetics, (including de novo mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention.What This Study Adds: This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk.Implications for practice, research, or policy: Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring. En ligne : http://dx.doi.org/10.1177/13623613211007319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

When conflict escalates into intimate partner violence: The delicate nature of observed coercion in adolescent romantic relationships / Thao HA in Development and Psychopathology, 31-5 (December 2019)  

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