A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months / Natasha CHERICONI in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3829-3842 Titre : A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months Type de document : Texte imprimé et/ou numérique Auteurs : Natasha CHERICONI, Auteur ; Giulia BALBONI, Auteur ; V. COSTANZO, Auteur ; A. MANCINI, Auteur ; M. PROSPERI, Auteur ; R. LASALA, Auteur ; Raffaella TANCREDI, Auteur ; M. L. SCATTONI, Auteur ; F. MURATORI, Auteur ; Fabio APICELLA, Auteur Article en page(s) : p.3829-3842 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Checklist  Child  Child Behavior  Humans  Male  Siblings  Autism spectrum disorder screening  Baby sibling paradigm  Cbcl 1½-5  Familial high-risk Index. décimale : PER Périodiques Résumé : The capacity of the Child Behavior Checklist 1½-5 (CBCL 1½-5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology. En ligne : http://dx.doi.org/10.1007/s10803-020-04838-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months [Texte imprimé et/ou numérique] / Natasha CHERICONI, Auteur ; Giulia BALBONI, Auteur ; V. COSTANZO, Auteur ; A. MANCINI, Auteur ; M. PROSPERI, Auteur ; R. LASALA, Auteur ; Raffaella TANCREDI, Auteur ; M. L. SCATTONI, Auteur ; F. MURATORI, Auteur ; Fabio APICELLA, Auteur . - p.3829-3842. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3829-3842 Mots-clés : Autism Spectrum Disorder/diagnosis  Checklist  Child  Child Behavior  Humans  Male  Siblings  Autism spectrum disorder screening  Baby sibling paradigm  Cbcl 1½-5  Familial high-risk Index. décimale : PER Périodiques Résumé : The capacity of the Child Behavior Checklist 1½-5 (CBCL 1½-5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology. En ligne : http://dx.doi.org/10.1007/s10803-020-04838-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development / S. HURLEY in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 16 p. Titre : Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development Type de document : Texte imprimé et/ou numérique Auteurs : S. HURLEY, Auteur ; C. MOHAN, Auteur ; P. SUETTERLIN, Auteur ; R. ELLINGFORD, Auteur ; K. L. H. RIEGMAN, Auteur ; J. ELLEGOOD, Auteur ; A. CARUSO, Auteur ; C. MICHETTI, Auteur ; O. BROCK, Auteur ; R. EVANS, Auteur ; F. RUDARI, Auteur ; A. DELOGU, Auteur ; M. L. SCATTONI, Auteur ; J. P. LERCH, Auteur ; C. FERNANDES, Auteur ; M. A. BASSON, Auteur Article en page(s) : 16 p. Langues : Anglais (eng) Mots-clés : Animals  Animals, Newborn  Autistic Disorder/genetics  Behavior, Animal  Brain/diagnostic imaging/embryology/growth & development  Cell Proliferation  DNA-Binding Proteins/deficiency/genetics  Disease Models, Animal  Female  Gene Expression Regulation, Developmental  Mice, Transgenic  Phenotype  Pregnancy  Stem Cells  Tumor Suppressor Protein p53/genetics  Apoptosis  Autism  Chd8  Chromatin  Conditional knockout  Cortex  Gene expression  Hypomorph  Intermediate progenitor  Mouse  Neural progenitor  Proliferation  Tbr2  p53  Pathways plc. This work is unrelated to COMPASS Pathways plc. No other competing  interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub-haploinsufficient Chd8 mouse models to allow us to identify and study the functions of CHD8 during embryonic cortical development. METHODS: To examine the possibility that certain phenotypes may only appear at sub-heterozygous Chd8 levels in the mouse, we created an allelic series of Chd8-deficient mice to reduce CHD8 protein levels to approximately 35% (mild hypomorph), 10% (severe hypomorph) and 0% (neural-specific conditional knockout) of wildtype levels. We used RNA sequencing to compare transcriptional dysregulation, structural MRI and brain weight to investigate effects on brain size, and cell proliferation, differentiation and apoptosis markers in immunostaining assays to quantify changes in neural progenitor fate. RESULTS: Mild Chd8 hypomorphs displayed significant postnatal lethality, with surviving animals exhibiting more pronounced brain hyperplasia than heterozygotes. Over 2000 genes were dysregulated in mild hypomorphs, including autism-associated neurodevelopmental and cell cycle genes. We identify increased proliferation of non-ventricular zone TBR2+ intermediate progenitors as one potential cause of brain hyperplasia in these mutants. Severe Chd8 hypomorphs displayed even greater transcriptional dysregulation, including evidence for p53 pathway upregulation. In contrast to mild hypomorphs, these mice displayed reduced brain size and increased apoptosis in the embryonic neocortex. Homozygous, conditional deletion of Chd8 in early neuronal progenitors resulted in pronounced brain hypoplasia, partly caused by p53 target gene derepression and apoptosis in the embryonic neocortex. Limitations Our findings identify an important role for the autism-associated factor CHD8 in controlling the proliferation of intermediate progenitors in the mouse neocortex. We propose that CHD8 has a similar function in human brain development, but studies on human cells are required to confirm this. Because many of our mouse mutants with reduced CHD8 function die shortly after birth, it is not possible to fully determine to what extent reduced CHD8 function results in autism-associated behaviours in mice. CONCLUSIONS: Together, these findings identify important, dosage-sensitive functions for CHD8 in p53 pathway repression, neurodevelopmental gene expression and neural progenitor fate in the embryonic neocortex. We conclude that brain development is acutely sensitive to reduced CHD8 expression and that the varying sensitivities of different progenitor populations and cellular processes to CHD8 dosage result in non-linear effects on gene transcription and brain growth. Shaun Hurley, Conor Mohan and Philipp Suetterlin have contributed equally to this work. En ligne : http://dx.doi.org/10.1186/s13229-020-00409-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development [Texte imprimé et/ou numérique] / S. HURLEY, Auteur ; C. MOHAN, Auteur ; P. SUETTERLIN, Auteur ; R. ELLINGFORD, Auteur ; K. L. H. RIEGMAN, Auteur ; J. ELLEGOOD, Auteur ; A. CARUSO, Auteur ; C. MICHETTI, Auteur ; O. BROCK, Auteur ; R. EVANS, Auteur ; F. RUDARI, Auteur ; A. DELOGU, Auteur ; M. L. SCATTONI, Auteur ; J. P. LERCH, Auteur ; C. FERNANDES, Auteur ; M. A. BASSON, Auteur . - 16 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 16 p. Mots-clés : Animals  Animals, Newborn  Autistic Disorder/genetics  Behavior, Animal  Brain/diagnostic imaging/embryology/growth & development  Cell Proliferation  DNA-Binding Proteins/deficiency/genetics  Disease Models, Animal  Female  Gene Expression Regulation, Developmental  Mice, Transgenic  Phenotype  Pregnancy  Stem Cells  Tumor Suppressor Protein p53/genetics  Apoptosis  Autism  Chd8  Chromatin  Conditional knockout  Cortex  Gene expression  Hypomorph  Intermediate progenitor  Mouse  Neural progenitor  Proliferation  Tbr2  p53  Pathways plc. This work is unrelated to COMPASS Pathways plc. No other competing  interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub-haploinsufficient Chd8 mouse models to allow us to identify and study the functions of CHD8 during embryonic cortical development. METHODS: To examine the possibility that certain phenotypes may only appear at sub-heterozygous Chd8 levels in the mouse, we created an allelic series of Chd8-deficient mice to reduce CHD8 protein levels to approximately 35% (mild hypomorph), 10% (severe hypomorph) and 0% (neural-specific conditional knockout) of wildtype levels. We used RNA sequencing to compare transcriptional dysregulation, structural MRI and brain weight to investigate effects on brain size, and cell proliferation, differentiation and apoptosis markers in immunostaining assays to quantify changes in neural progenitor fate. RESULTS: Mild Chd8 hypomorphs displayed significant postnatal lethality, with surviving animals exhibiting more pronounced brain hyperplasia than heterozygotes. Over 2000 genes were dysregulated in mild hypomorphs, including autism-associated neurodevelopmental and cell cycle genes. We identify increased proliferation of non-ventricular zone TBR2+ intermediate progenitors as one potential cause of brain hyperplasia in these mutants. Severe Chd8 hypomorphs displayed even greater transcriptional dysregulation, including evidence for p53 pathway upregulation. In contrast to mild hypomorphs, these mice displayed reduced brain size and increased apoptosis in the embryonic neocortex. Homozygous, conditional deletion of Chd8 in early neuronal progenitors resulted in pronounced brain hypoplasia, partly caused by p53 target gene derepression and apoptosis in the embryonic neocortex. Limitations Our findings identify an important role for the autism-associated factor CHD8 in controlling the proliferation of intermediate progenitors in the mouse neocortex. We propose that CHD8 has a similar function in human brain development, but studies on human cells are required to confirm this. Because many of our mouse mutants with reduced CHD8 function die shortly after birth, it is not possible to fully determine to what extent reduced CHD8 function results in autism-associated behaviours in mice. CONCLUSIONS: Together, these findings identify important, dosage-sensitive functions for CHD8 in p53 pathway repression, neurodevelopmental gene expression and neural progenitor fate in the embryonic neocortex. We conclude that brain development is acutely sensitive to reduced CHD8 expression and that the varying sensitivities of different progenitor populations and cellular processes to CHD8 dosage result in non-linear effects on gene transcription and brain growth. Shaun Hurley, Conor Mohan and Philipp Suetterlin have contributed equally to this work. En ligne : http://dx.doi.org/10.1186/s13229-020-00409-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Early developmental trajectories of expressive vocabulary and gesture production in a longitudinal cohort of Italian infants at high-risk for Autism Spectrum Disorder / V. RIVA in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1421-1433 Titre : Early developmental trajectories of expressive vocabulary and gesture production in a longitudinal cohort of Italian infants at high-risk for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : V. RIVA, Auteur ; A. CARUSO, Auteur ; Fabio APICELLA, Auteur ; G. VALERI, Auteur ; S. VICARI, Auteur ; M. MOLTENI, Auteur ; M. L. SCATTONI, Auteur Article en page(s) : p.1421-1433 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Gestures  Humans  Infant  Italy  Language Development Disorders  Vocabulary  developmental trajectory  expressive language  gesture  infant sibling Index. décimale : PER Périodiques Résumé : Delays in language are a hallmark feature of Autism Spectrum Disorder (ASD). However, little is known about the predictive role of language developmental trajectories on ASD. The present study aimed at identifying early different language developmental profiles of infants at high familial risk for ASD (HR-ASD) and testing their predictive role on ASD symptoms at 2?years. The role of gestures on socio-communicative skills has also been explored. Trajectories of expressive vocabulary were investigated in 137 HR-ASD infants at 12, 18, and, 24?months of age. Parents were requested to complete the Italian version of the MacArthur-Bates Communicative Development Inventory and ASD symptoms were measured by ADOS-2. Latent class growth analysis defined four trajectories: above average language development group (above-average LD, 18.2%), normal language development group (NLD, 38.7%), late-onset language development group (late-onset LD, 11.7%), and a group of children with stable language delay (SLD, 31.4%). Results showed that the SLD group obtained higher communicative difficulties and restricted/repetitive behavior compared to the other groups. Examining early increase of produced gestures in the different language classes, we found fewer produced gestures between 12 and 18?months in the SLD group compared to the late-onset LD group. The results identified clusters of HR infants who follow similar estimated trajectories based on individual differences in language development. These patterns of early language acquisition, together with produced gestures, may be predictive of later ASD symptoms and useful for planning prompt intervention. LAY SUMMARY: Language/gesture deficits are hallmark features of Autism Spectrum Disorder (ASD), but the predictive role of communicative trajectories on ASD remains unclear. In a longitudinal Italian sample of infants at high familial risk for ASD (HR-ASD), we tested if language trajectories and their link with gestures can predict ASD symptoms. We found four trajectories and HR infants with a stable language delay (SLD) trajectory showed more ASD symptoms later on. SLD infants produced fewer gestures compared to late-onset language development group that show more typical communicative skills. En ligne : http://dx.doi.org/10.1002/aur.2493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Early developmental trajectories of expressive vocabulary and gesture production in a longitudinal cohort of Italian infants at high-risk for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / V. RIVA, Auteur ; A. CARUSO, Auteur ; Fabio APICELLA, Auteur ; G. VALERI, Auteur ; S. VICARI, Auteur ; M. MOLTENI, Auteur ; M. L. SCATTONI, Auteur . - p.1421-1433. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1421-1433 Mots-clés : Autism Spectrum Disorder  Child  Gestures  Humans  Infant  Italy  Language Development Disorders  Vocabulary  developmental trajectory  expressive language  gesture  infant sibling Index. décimale : PER Périodiques Résumé : Delays in language are a hallmark feature of Autism Spectrum Disorder (ASD). However, little is known about the predictive role of language developmental trajectories on ASD. The present study aimed at identifying early different language developmental profiles of infants at high familial risk for ASD (HR-ASD) and testing their predictive role on ASD symptoms at 2?years. The role of gestures on socio-communicative skills has also been explored. Trajectories of expressive vocabulary were investigated in 137 HR-ASD infants at 12, 18, and, 24?months of age. Parents were requested to complete the Italian version of the MacArthur-Bates Communicative Development Inventory and ASD symptoms were measured by ADOS-2. Latent class growth analysis defined four trajectories: above average language development group (above-average LD, 18.2%), normal language development group (NLD, 38.7%), late-onset language development group (late-onset LD, 11.7%), and a group of children with stable language delay (SLD, 31.4%). Results showed that the SLD group obtained higher communicative difficulties and restricted/repetitive behavior compared to the other groups. Examining early increase of produced gestures in the different language classes, we found fewer produced gestures between 12 and 18?months in the SLD group compared to the late-onset LD group. The results identified clusters of HR infants who follow similar estimated trajectories based on individual differences in language development. These patterns of early language acquisition, together with produced gestures, may be predictive of later ASD symptoms and useful for planning prompt intervention. LAY SUMMARY: Language/gesture deficits are hallmark features of Autism Spectrum Disorder (ASD), but the predictive role of communicative trajectories on ASD remains unclear. In a longitudinal Italian sample of infants at high familial risk for ASD (HR-ASD), we tested if language trajectories and their link with gestures can predict ASD symptoms. We found four trajectories and HR infants with a stable language delay (SLD) trajectory showed more ASD symptoms later on. SLD infants produced fewer gestures compared to late-onset language development group that show more typical communicative skills. En ligne : http://dx.doi.org/10.1002/aur.2493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study / L. TURRIZIANI in Autism Research, 15-1 (January 2022)  

Public ISBD [article]  inAutism Research > 15-1 (January 2022) . - p.56-69 Titre : Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study Type de document : Texte imprimé et/ou numérique Auteurs : L. TURRIZIANI, Auteur ; A. RICCIARDELLO, Auteur ; F. CUCINOTTA, Auteur ; F. BELLOMO, Auteur ; G. TURTURO, Auteur ; M. BONCODDO, Auteur ; S. MIRABELLI, Auteur ; M. L. SCATTONI, Auteur ; M. ROSSI, Auteur ; A. M. PERSICO, Auteur Article en page(s) : p.56-69 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder/complications  Behavioral Symptoms  Child  Child, Preschool  Constipation/complications  Cresols/urine  Gastrointestinal Microbiome  Gastrointestinal Motility  Humans  Prospective Studies  4-cresol  anxiety  autism  autism spectrum disorder  biomarkers  constipation  microbiota Index. décimale : PER Périodiques Résumé : Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors. Young autistic children with chronic constipation display higher urinary, and foecal concentrations of p-cresol, an aromatic compound produced by gut bacteria, known to negatively affect brain function. Acute p-cresol administration to BTBR mice enhances anxiety, hyperactivity and stereotypic behaviors, while blunting social interaction. This study was undertaken to prospectively assess the behavioral effects of gut mobilization in young autistic children with chronic constipation, and to verify their possible correlation with urinary p-cresol. To this aim, 21 chronically constipated autistic children 2-8?years old were evaluated before (T0), 1?month (T1), and 6?months (T2) after intestinal mobilization, recording Bristol stool scale scores, urinary p-cresol concentrations, and behavioral scores for social interaction deficits, stereotypic behaviors, anxiety, and hyperactivity. Gut mobilization yielded a progressive and highly significant decrease in all behavioral symptoms over the 6-month study period. Urinary p-cresol levels displayed variable trends not significantly correlated with changes in behavioral parameters, mainly increasing at T1 and decreasing at T2. These results support gut mobilization as a simple strategy to ameliorate ASD symptoms, as well as comorbid anxiety and hyperactivity, in chronically constipated children. Variation in p-cresol absorption seemingly provides limited contributions, if any, to these behavioral changes. Further research will be needed to address the relative role of reduced abdominal discomfort following mobilization, as compared to specific modifications in microbiome composition and in gut bacteria-derived neuroactive compounds. En ligne : http://dx.doi.org/10.1002/aur.2639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study [Texte imprimé et/ou numérique] / L. TURRIZIANI, Auteur ; A. RICCIARDELLO, Auteur ; F. CUCINOTTA, Auteur ; F. BELLOMO, Auteur ; G. TURTURO, Auteur ; M. BONCODDO, Auteur ; S. MIRABELLI, Auteur ; M. L. SCATTONI, Auteur ; M. ROSSI, Auteur ; A. M. PERSICO, Auteur . - p.56-69. Langues : Anglais (eng) in Autism Research > 15-1 (January 2022) . - p.56-69 Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder/complications  Behavioral Symptoms  Child  Child, Preschool  Constipation/complications  Cresols/urine  Gastrointestinal Microbiome  Gastrointestinal Motility  Humans  Prospective Studies  4-cresol  anxiety  autism  autism spectrum disorder  biomarkers  constipation  microbiota Index. décimale : PER Périodiques Résumé : Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors. Young autistic children with chronic constipation display higher urinary, and foecal concentrations of p-cresol, an aromatic compound produced by gut bacteria, known to negatively affect brain function. Acute p-cresol administration to BTBR mice enhances anxiety, hyperactivity and stereotypic behaviors, while blunting social interaction. This study was undertaken to prospectively assess the behavioral effects of gut mobilization in young autistic children with chronic constipation, and to verify their possible correlation with urinary p-cresol. To this aim, 21 chronically constipated autistic children 2-8?years old were evaluated before (T0), 1?month (T1), and 6?months (T2) after intestinal mobilization, recording Bristol stool scale scores, urinary p-cresol concentrations, and behavioral scores for social interaction deficits, stereotypic behaviors, anxiety, and hyperactivity. Gut mobilization yielded a progressive and highly significant decrease in all behavioral symptoms over the 6-month study period. Urinary p-cresol levels displayed variable trends not significantly correlated with changes in behavioral parameters, mainly increasing at T1 and decreasing at T2. These results support gut mobilization as a simple strategy to ameliorate ASD symptoms, as well as comorbid anxiety and hyperactivity, in chronically constipated children. Variation in p-cresol absorption seemingly provides limited contributions, if any, to these behavioral changes. Further research will be needed to address the relative role of reduced abdominal discomfort following mobilization, as compared to specific modifications in microbiome composition and in gut bacteria-derived neuroactive compounds. En ligne : http://dx.doi.org/10.1002/aur.2639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Real-World Experiences in Autistic Adult Diagnostic Services and Post-diagnostic Support and Alignment with Services Guidelines: Results from the ASDEU Study / M. L. SCATTONI in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4129-4146 Titre : Real-World Experiences in Autistic Adult Diagnostic Services and Post-diagnostic Support and Alignment with Services Guidelines: Results from the ASDEU Study Type de document : Texte imprimé et/ou numérique Auteurs : M. L. SCATTONI, Auteur ; M. MICAI, Auteur ; A. CIARAMELLA, Auteur ; T. SALVITTI, Auteur ; F. FULCERI, Auteur ; L. M. FATTA, Auteur ; L. POUSTKA, Auteur ; R. DIEHM, Auteur ; G. ISKROV, Auteur ; R. STEFANOV, Auteur ; Q. GUILLON, Auteur ; Bernadette ROGE, Auteur ; A. STAINES, Auteur ; M. R. SWEENEY, Auteur ; Andrew Martin BOILSON, Auteur ; T. LEÓSDÓTTIR, Auteur ; Evald SAEMUNDSEN, Auteur ; I. MOILANEN, Auteur ; H. EBELING, Auteur ; A. YLIHERVA, Auteur ; M. GISSLER, Auteur ; T. PARVIAINEN, Auteur ; P. TANI, Auteur ; R. KAWA, Auteur ; A. VICENTE, Auteur ; C. RASGA, Auteur ; Magdalena BUDISTEANU, Auteur ; I. DALE, Auteur ; C. POVEY, Auteur ; N. FLORES, Auteur ; C. JENARO, Auteur ; M. L. MONROY, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Tony CHARMAN, Auteur ; S. CRAMER, Auteur ; C. K. WARBERG, Auteur ; Ricardo CANAL-BEDIA, Auteur ; M. POSADA, Auteur ; Diana SCHENDEL, Auteur Article en page(s) : p.4129-4146 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Diagnostic Services  European Union  Humans  Surveys and Questionnaires  Adults  Autism spectrum disorder  Diagnosis  Services Index. décimale : PER Périodiques Résumé : Research providing an evidence-base for autistic adult services is sparse. The Autism Spectrum Disorders in the European Union (ASDEU) network implemented an on-line survey to determine gaps in autistic adult diagnostic evaluation and post-diagnostic support services. More than 55% in all groups experienced most of the recommended features for diagnostic evaluation for autistic adults. In contrast,? En ligne : http://dx.doi.org/10.1007/s10803-021-04873-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Real-World Experiences in Autistic Adult Diagnostic Services and Post-diagnostic Support and Alignment with Services Guidelines: Results from the ASDEU Study [Texte imprimé et/ou numérique] / M. L. SCATTONI, Auteur ; M. MICAI, Auteur ; A. CIARAMELLA, Auteur ; T. SALVITTI, Auteur ; F. FULCERI, Auteur ; L. M. FATTA, Auteur ; L. POUSTKA, Auteur ; R. DIEHM, Auteur ; G. ISKROV, Auteur ; R. STEFANOV, Auteur ; Q. GUILLON, Auteur ; Bernadette ROGE, Auteur ; A. STAINES, Auteur ; M. R. SWEENEY, Auteur ; Andrew Martin BOILSON, Auteur ; T. LEÓSDÓTTIR, Auteur ; Evald SAEMUNDSEN, Auteur ; I. MOILANEN, Auteur ; H. EBELING, Auteur ; A. YLIHERVA, Auteur ; M. GISSLER, Auteur ; T. PARVIAINEN, Auteur ; P. TANI, Auteur ; R. KAWA, Auteur ; A. VICENTE, Auteur ; C. RASGA, Auteur ; Magdalena BUDISTEANU, Auteur ; I. DALE, Auteur ; C. POVEY, Auteur ; N. FLORES, Auteur ; C. JENARO, Auteur ; M. L. MONROY, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Tony CHARMAN, Auteur ; S. CRAMER, Auteur ; C. K. WARBERG, Auteur ; Ricardo CANAL-BEDIA, Auteur ; M. POSADA, Auteur ; Diana SCHENDEL, Auteur . - p.4129-4146. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4129-4146 Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Diagnostic Services  European Union  Humans  Surveys and Questionnaires  Adults  Autism spectrum disorder  Diagnosis  Services Index. décimale : PER Périodiques Résumé : Research providing an evidence-base for autistic adult services is sparse. The Autism Spectrum Disorders in the European Union (ASDEU) network implemented an on-line survey to determine gaps in autistic adult diagnostic evaluation and post-diagnostic support services. More than 55% in all groups experienced most of the recommended features for diagnostic evaluation for autistic adults. In contrast,? En ligne : http://dx.doi.org/10.1007/s10803-021-04873-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

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