Dépouillements

Issue Information in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1017-1021 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1017-1021 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1699 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Issue Information [Texte imprimé et/ou numérique] . - p.1017-1021. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1017-1021 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1699 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper / Christopher GILLBERG in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1022-1044 Titre : The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper Type de document : Texte imprimé et/ou numérique Auteurs : Christopher GILLBERG, Auteur ; Elisabeth FERNELL, Auteur ; Eva KOCOVSKA, Auteur ; Helen MINNIS, Auteur ; Thomas BOURGERON, Auteur ; Lucy THOMPSON, Auteur ; Clare S. ALLELY, Auteur Article en page(s) : p.1022-1044 Langues : Anglais (eng) Mots-clés : autism  cholesterol  cortisol  estrogens  steroid hormones  testosterone  vitamin D Index. décimale : PER Périodiques Résumé : Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the “autisms” [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as “steroid metabolism” and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. En ligne : http://dx.doi.org/10.1002/aur.1777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper [Texte imprimé et/ou numérique] / Christopher GILLBERG, Auteur ; Elisabeth FERNELL, Auteur ; Eva KOCOVSKA, Auteur ; Helen MINNIS, Auteur ; Thomas BOURGERON, Auteur ; Lucy THOMPSON, Auteur ; Clare S. ALLELY, Auteur . - p.1022-1044. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1022-1044 Mots-clés : autism  cholesterol  cortisol  estrogens  steroid hormones  testosterone  vitamin D Index. décimale : PER Périodiques Résumé : Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the “autisms” [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as “steroid metabolism” and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. En ligne : http://dx.doi.org/10.1002/aur.1777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Perception of odors and tastes in autism spectrum disorders: A systematic review of assessments / Mohamed A. BOUDJARANE in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1045-1057 Titre : Perception of odors and tastes in autism spectrum disorders: A systematic review of assessments Type de document : Texte imprimé et/ou numérique Auteurs : Mohamed A. BOUDJARANE, Auteur ; Marine GRANDGEORGE, Auteur ; Rémi MARIANOWSKI, Auteur ; Laurent MISERY, Auteur ; Eric LEMONNIER, Auteur Article en page(s) : p.1045-1057 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  sensory dysfunctions  sensory system  psychophysics  review Index. décimale : PER Périodiques Résumé : Olfaction and gustation are major sensory functions implied in processing environmental stimuli. Some evidences suggest that loss of olfactory function is an early biomarker for neurodegenerative disorders and atypical processing of odor and taste stimuli is present in several neurodevelopmental disorders, notably in Autism Spectrum Disorders (ASD). In this paper, we conducted a systematic review investigating the assessments of olfaction and gustation with psychophysics methods in individuals with ASD. Pubmed, PMC and Sciencedirect were scrutinized for relevant literature published from 1970 to 2015. In this review, fourteen papers met our inclusion criteria. They were analyzed critically in order to evaluate the occurrence of olfactory and gustatory dysfunction in ASD, as well as to report the methods used to assess olfaction and gustation in such conditions. Regarding to these two senses, the overall number of studies is low. Most of studies show significant difference regarding to odor or taste identification but not for detection threshold. Overall, odor rating through pleasantness, intensity and familiarity do not differ significantly between control and individuals with ASD. The current evidences can suggest the presence of olfactory and gustatory dysfunction in ASD. Therefore, our analysis show a heterogeneity of findings. This is due to several methodological limitations such as the tools used or population studied. Understanding these disorders could help to shed light on other atypical behavior in this population such as feeding or social behavior. En ligne : http://dx.doi.org/10.1002/aur.1760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Perception of odors and tastes in autism spectrum disorders: A systematic review of assessments [Texte imprimé et/ou numérique] / Mohamed A. BOUDJARANE, Auteur ; Marine GRANDGEORGE, Auteur ; Rémi MARIANOWSKI, Auteur ; Laurent MISERY, Auteur ; Eric LEMONNIER, Auteur . - p.1045-1057. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1045-1057 Mots-clés : autism spectrum disorders  sensory dysfunctions  sensory system  psychophysics  review Index. décimale : PER Périodiques Résumé : Olfaction and gustation are major sensory functions implied in processing environmental stimuli. Some evidences suggest that loss of olfactory function is an early biomarker for neurodegenerative disorders and atypical processing of odor and taste stimuli is present in several neurodevelopmental disorders, notably in Autism Spectrum Disorders (ASD). In this paper, we conducted a systematic review investigating the assessments of olfaction and gustation with psychophysics methods in individuals with ASD. Pubmed, PMC and Sciencedirect were scrutinized for relevant literature published from 1970 to 2015. In this review, fourteen papers met our inclusion criteria. They were analyzed critically in order to evaluate the occurrence of olfactory and gustatory dysfunction in ASD, as well as to report the methods used to assess olfaction and gustation in such conditions. Regarding to these two senses, the overall number of studies is low. Most of studies show significant difference regarding to odor or taste identification but not for detection threshold. Overall, odor rating through pleasantness, intensity and familiarity do not differ significantly between control and individuals with ASD. The current evidences can suggest the presence of olfactory and gustatory dysfunction in ASD. Therefore, our analysis show a heterogeneity of findings. This is due to several methodological limitations such as the tools used or population studied. Understanding these disorders could help to shed light on other atypical behavior in this population such as feeding or social behavior. En ligne : http://dx.doi.org/10.1002/aur.1760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

The urinary 1H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings / Milena LUSSU in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1058-1066 Titre : The urinary 1H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings Type de document : Texte imprimé et/ou numérique Auteurs : Milena LUSSU, Auteur ; Antonio NOTO, Auteur ; Alice MASILI, Auteur ; Andrea C. RINALDI, Auteur ; Angelica DESSÌ, Auteur ; Maria DE ANGELIS, Auteur ; Andrea DE GIACOMO, Auteur ; Vassilios FANOS, Auteur ; Luigi ATZORI, Auteur ; Ruggiero FRANCAVILLA, Auteur Article en page(s) : p.1058-1066 Langues : Anglais (eng) Mots-clés : metabolomics  autistic children  siblings  biomarkers Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) make a dishomogeneous group of psychiatric diseases having either genetic and environmental components, including changes of the microbiota. The rate of diagnosis, based on a series of psychological tests and observed behavior, dramatically increased in the past few decades. Currently, no biological markers are available and the pathogenesis is not defined. The purpose of this study was to evaluate the potential use of 1H-NMR metabolomics to analyze the global biochemical signature of ASD patients (n?=?21) and controls (n?=?21), these being siblings of autistic patients. A multivariate model has been used to extrapolate the variables of importance. The discriminating urinary metabolites were identified; in particular, significantly increased levels of hippurate, glycine, creatine, tryptophan, and d-threitol and decreased concentrations of glutamate, creatinine, lactate, valine, betaine, and taurine were observed in ASD patients. Based on the identified discriminant metabolites, the attention was focused on two possible mechanisms that could be involved in ASD: oxidative stress conditions and gut microflora modifications. In conclusion, nuclear magnetic resonance-based metabolomics analysis of the urine seems to have the potential for the identification of a metabolic fingerprint of ASD phenotypes and appears to be suitable for further investigation of the disease mechanisms. En ligne : http://dx.doi.org/10.1002/aur.1748 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] The urinary 1H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings [Texte imprimé et/ou numérique] / Milena LUSSU, Auteur ; Antonio NOTO, Auteur ; Alice MASILI, Auteur ; Andrea C. RINALDI, Auteur ; Angelica DESSÌ, Auteur ; Maria DE ANGELIS, Auteur ; Andrea DE GIACOMO, Auteur ; Vassilios FANOS, Auteur ; Luigi ATZORI, Auteur ; Ruggiero FRANCAVILLA, Auteur . - p.1058-1066. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1058-1066 Mots-clés : metabolomics  autistic children  siblings  biomarkers Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) make a dishomogeneous group of psychiatric diseases having either genetic and environmental components, including changes of the microbiota. The rate of diagnosis, based on a series of psychological tests and observed behavior, dramatically increased in the past few decades. Currently, no biological markers are available and the pathogenesis is not defined. The purpose of this study was to evaluate the potential use of 1H-NMR metabolomics to analyze the global biochemical signature of ASD patients (n?=?21) and controls (n?=?21), these being siblings of autistic patients. A multivariate model has been used to extrapolate the variables of importance. The discriminating urinary metabolites were identified; in particular, significantly increased levels of hippurate, glycine, creatine, tryptophan, and d-threitol and decreased concentrations of glutamate, creatinine, lactate, valine, betaine, and taurine were observed in ASD patients. Based on the identified discriminant metabolites, the attention was focused on two possible mechanisms that could be involved in ASD: oxidative stress conditions and gut microflora modifications. In conclusion, nuclear magnetic resonance-based metabolomics analysis of the urine seems to have the potential for the identification of a metabolic fingerprint of ASD phenotypes and appears to be suitable for further investigation of the disease mechanisms. En ligne : http://dx.doi.org/10.1002/aur.1748 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Age-specific autistic-like behaviors in heterozygous Fmr1-KO female mice / Manon GAUDUCHEAU in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1067-1078 Titre : Age-specific autistic-like behaviors in heterozygous Fmr1-KO female mice Type de document : Texte imprimé et/ou numérique Auteurs : Manon GAUDUCHEAU, Auteur ; Valerie LEMAIRE-MAYO, Auteur ; Francesca R. D'AMATO, Auteur ; Diego ODDI, Auteur ; Wim E. CRUSIO, Auteur ; Susanna PIETROPAOLO, Auteur Article en page(s) : p.1067-1078 Langues : Anglais (eng) Mots-clés : adolescence  ultrasonic vocalizations  social interactions  developmental disorders  Fragile X syndrome  animal models  autism Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a major developmental disorder and the most frequent monogenic cause of autism. Surprisingly, most existing studies on the Fmr1-KO mouse model for FXS have focused on males, although FX women, who are mostly heterozygous for the Fmr1 mutation, are known to exhibit several behavioral deficits, including autistic-like features. Furthermore, most animal research has been carried out on adults only; so that little is known about the age progression of the behavioral phenotype of Fmr1 mutants, which is a crucial issue to optimize the impact of therapeutic interventions. Here, we performed an extensive analysis of autistic-like social behaviors in heterozygous (HET) Fmr1-KO females and their WT littermates at different ages. No behavioral difference between HET and WT mice was observed at infancy, but some abnormalities in social interaction and communication were first detected at juvenile age. At adulthood some of these alterations disappeared, but avoidance of social novelty appeared, together with other FXS-relevant behavioral deficits, such as hyperactivity and reduced contextual fear response. Our data provide for the first time evidence for the presence of autistic-relevant behavioral abnormalities in Fmr1-HET female mice, demonstrating the utility of this mouse line to model autistic-like behaviors in both sexes. These results also highlight the importance of taking into account age differences when using the Fmr1-KO mouse model, suggesting that the early post-natal phases are the most promising target for preventive interventions and the adult age is the most appropriate to investigate the behavioral impact of potential therapies. En ligne : http://dx.doi.org/10.1002/aur.1743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Age-specific autistic-like behaviors in heterozygous Fmr1-KO female mice [Texte imprimé et/ou numérique] / Manon GAUDUCHEAU, Auteur ; Valerie LEMAIRE-MAYO, Auteur ; Francesca R. D'AMATO, Auteur ; Diego ODDI, Auteur ; Wim E. CRUSIO, Auteur ; Susanna PIETROPAOLO, Auteur . - p.1067-1078. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1067-1078 Mots-clés : adolescence  ultrasonic vocalizations  social interactions  developmental disorders  Fragile X syndrome  animal models  autism Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a major developmental disorder and the most frequent monogenic cause of autism. Surprisingly, most existing studies on the Fmr1-KO mouse model for FXS have focused on males, although FX women, who are mostly heterozygous for the Fmr1 mutation, are known to exhibit several behavioral deficits, including autistic-like features. Furthermore, most animal research has been carried out on adults only; so that little is known about the age progression of the behavioral phenotype of Fmr1 mutants, which is a crucial issue to optimize the impact of therapeutic interventions. Here, we performed an extensive analysis of autistic-like social behaviors in heterozygous (HET) Fmr1-KO females and their WT littermates at different ages. No behavioral difference between HET and WT mice was observed at infancy, but some abnormalities in social interaction and communication were first detected at juvenile age. At adulthood some of these alterations disappeared, but avoidance of social novelty appeared, together with other FXS-relevant behavioral deficits, such as hyperactivity and reduced contextual fear response. Our data provide for the first time evidence for the presence of autistic-relevant behavioral abnormalities in Fmr1-HET female mice, demonstrating the utility of this mouse line to model autistic-like behaviors in both sexes. These results also highlight the importance of taking into account age differences when using the Fmr1-KO mouse model, suggesting that the early post-natal phases are the most promising target for preventive interventions and the adult age is the most appropriate to investigate the behavioral impact of potential therapies. En ligne : http://dx.doi.org/10.1002/aur.1743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis / Franco CAUDA in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1079-1095 Titre : Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Franco CAUDA, Auteur ; Tommaso COSTA, Auteur ; Andrea NANI, Auteur ; Luciano FAVA, Auteur ; Sara PALERMO, Auteur ; Francesca BIANCO, Auteur ; Sergio DUCA, Auteur ; Karina TATU, Auteur ; Roberto KELLER, Auteur Article en page(s) : p.1079-1095 Langues : Anglais (eng) Mots-clés : brain alterations  neuroimaging  schizophrenia spectrum disorder  autism spectrum disorder  obsessive-compulsive spectrum disorder  psychiatric categories  core alterations Index. décimale : PER Périodiques Résumé : Schizophrenia spectrum disorder (SCZD), autism spectrum disorder (ASD), and obsessive-compulsive spectrum disorder (OCSD) are considered as three separate psychiatric conditions with, supposedly, different brain alterations patterns. From a neuroimaging perspective, this meta-analytic study aimed to address whether this nosographical differentiation is actually supported by different brain patterns of gray matter (GM) or white matter (WM) morphological alterations. We explored two possibilities: (a) to find out whether GM alterations are specific for SCZD, ASD, and OCSD; and (b) to associate the identified brain alteration patterns with cognitive dysfunctions by means of an analysis of lesion decoding. Our analysis reveals that these psychiatric spectra do not present clear distinctive patterns of alterations; rather, they all tend to be distributed in two alteration clusters. Cluster 1, which is more specific for SCZD, includes the anterior insular, anterior cingulate cortex, ventromedial prefrontal cortex, and frontopolar areas, which are parts of the cognitive control system. Cluster 2, which is more specific for OCSD, presents occipital, temporal, and parietal alteration patterns with the involvement of sensorimotor, premotor, visual, and lingual areas, thus forming a network that is more associated with the auditory-visual, auditory, premotor visual somatic functions. In turn, ASD appears to be uniformly distributed in the two clusters. The three spectra share a significant set of alterations. Our new approach promises to provide insight into the understanding of psychiatric conditions under the aspect of a common neurobiological substrate, possibly related to neuroinflammation during brain development. En ligne : http://dx.doi.org/10.1002/aur.1759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis [Texte imprimé et/ou numérique] / Franco CAUDA, Auteur ; Tommaso COSTA, Auteur ; Andrea NANI, Auteur ; Luciano FAVA, Auteur ; Sara PALERMO, Auteur ; Francesca BIANCO, Auteur ; Sergio DUCA, Auteur ; Karina TATU, Auteur ; Roberto KELLER, Auteur . - p.1079-1095. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1079-1095 Mots-clés : brain alterations  neuroimaging  schizophrenia spectrum disorder  autism spectrum disorder  obsessive-compulsive spectrum disorder  psychiatric categories  core alterations Index. décimale : PER Périodiques Résumé : Schizophrenia spectrum disorder (SCZD), autism spectrum disorder (ASD), and obsessive-compulsive spectrum disorder (OCSD) are considered as three separate psychiatric conditions with, supposedly, different brain alterations patterns. From a neuroimaging perspective, this meta-analytic study aimed to address whether this nosographical differentiation is actually supported by different brain patterns of gray matter (GM) or white matter (WM) morphological alterations. We explored two possibilities: (a) to find out whether GM alterations are specific for SCZD, ASD, and OCSD; and (b) to associate the identified brain alteration patterns with cognitive dysfunctions by means of an analysis of lesion decoding. Our analysis reveals that these psychiatric spectra do not present clear distinctive patterns of alterations; rather, they all tend to be distributed in two alteration clusters. Cluster 1, which is more specific for SCZD, includes the anterior insular, anterior cingulate cortex, ventromedial prefrontal cortex, and frontopolar areas, which are parts of the cognitive control system. Cluster 2, which is more specific for OCSD, presents occipital, temporal, and parietal alteration patterns with the involvement of sensorimotor, premotor, visual, and lingual areas, thus forming a network that is more associated with the auditory-visual, auditory, premotor visual somatic functions. In turn, ASD appears to be uniformly distributed in the two clusters. The three spectra share a significant set of alterations. Our new approach promises to provide insight into the understanding of psychiatric conditions under the aspect of a common neurobiological substrate, possibly related to neuroinflammation during brain development. En ligne : http://dx.doi.org/10.1002/aur.1759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Binocular rivalry in children on the autism spectrum / Themis KARAMINIS in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1096-1106 Titre : Binocular rivalry in children on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Themis KARAMINIS, Auteur ; Claudia LUNGHI, Auteur ; Louise NEIL, Auteur ; David BURR, Auteur ; Elizabeth PELLICANO, Auteur Article en page(s) : p.1096-1106 Langues : Anglais (eng) Mots-clés : binocular rivalry  autism  perception  bistable perception  vision  atypical development Index. décimale : PER Périodiques Résumé : When different images are presented to the eyes, the brain is faced with ambiguity, causing perceptual bistability: visual perception continuously alternates between the monocular images, a phenomenon called binocular rivalry. Many models of rivalry suggest that its temporal dynamics depend on mutual inhibition among neurons representing competing images. These models predict that rivalry should be different in autism, which has been proposed to present an atypical ratio of excitation and inhibition [the E/I imbalance hypothesis; Rubenstein & Merzenich, 2003]. In line with this prediction, some recent studies have provided evidence for atypical binocular rivalry dynamics in autistic adults. In this study, we examined if these findings generalize to autistic children. We developed a child-friendly binocular rivalry paradigm, which included two types of stimuli, low- and high-complexity, and compared rivalry dynamics in groups of autistic and age- and intellectual ability-matched typical children. Unexpectedly, the two groups of children presented the same number of perceptual transitions and the same mean phase durations (times perceiving one of the two stimuli). Yet autistic children reported mixed percepts for a shorter proportion of time (a difference which was in the opposite direction to previous adult studies), while elevated autistic symptomatology was associated with shorter mixed perception periods. Rivalry in the two groups was affected similarly by stimulus type, and consistent with previous findings. Our results suggest that rivalry dynamics are differentially affected in adults and developing autistic children and could be accounted for by hierarchical models of binocular rivalry, including both inhibition and top-down influences. En ligne : http://dx.doi.org/10.1002/aur.1749 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Binocular rivalry in children on the autism spectrum [Texte imprimé et/ou numérique] / Themis KARAMINIS, Auteur ; Claudia LUNGHI, Auteur ; Louise NEIL, Auteur ; David BURR, Auteur ; Elizabeth PELLICANO, Auteur . - p.1096-1106. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1096-1106 Mots-clés : binocular rivalry  autism  perception  bistable perception  vision  atypical development Index. décimale : PER Périodiques Résumé : When different images are presented to the eyes, the brain is faced with ambiguity, causing perceptual bistability: visual perception continuously alternates between the monocular images, a phenomenon called binocular rivalry. Many models of rivalry suggest that its temporal dynamics depend on mutual inhibition among neurons representing competing images. These models predict that rivalry should be different in autism, which has been proposed to present an atypical ratio of excitation and inhibition [the E/I imbalance hypothesis; Rubenstein & Merzenich, 2003]. In line with this prediction, some recent studies have provided evidence for atypical binocular rivalry dynamics in autistic adults. In this study, we examined if these findings generalize to autistic children. We developed a child-friendly binocular rivalry paradigm, which included two types of stimuli, low- and high-complexity, and compared rivalry dynamics in groups of autistic and age- and intellectual ability-matched typical children. Unexpectedly, the two groups of children presented the same number of perceptual transitions and the same mean phase durations (times perceiving one of the two stimuli). Yet autistic children reported mixed percepts for a shorter proportion of time (a difference which was in the opposite direction to previous adult studies), while elevated autistic symptomatology was associated with shorter mixed perception periods. Rivalry in the two groups was affected similarly by stimulus type, and consistent with previous findings. Our results suggest that rivalry dynamics are differentially affected in adults and developing autistic children and could be accounted for by hierarchical models of binocular rivalry, including both inhibition and top-down influences. En ligne : http://dx.doi.org/10.1002/aur.1749 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Neural correlates of language variability in preschool-aged boys with autism spectrum disorder / Letitia R. NAIGLES in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1107-1119 Titre : Neural correlates of language variability in preschool-aged boys with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Letitia R. NAIGLES, Auteur ; Ryan JOHNSON, Auteur ; Ann MASTERGEORGE, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.1107-1119 Langues : Anglais (eng) Mots-clés : DTI  brain imaging  language development  preschoolers Index. décimale : PER Périodiques Résumé : Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships. En ligne : http://dx.doi.org/10.1002/aur.1756 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Neural correlates of language variability in preschool-aged boys with autism spectrum disorder [Texte imprimé et/ou numérique] / Letitia R. NAIGLES, Auteur ; Ryan JOHNSON, Auteur ; Ann MASTERGEORGE, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur . - p.1107-1119. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1107-1119 Mots-clés : DTI  brain imaging  language development  preschoolers Index. décimale : PER Périodiques Résumé : Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships. En ligne : http://dx.doi.org/10.1002/aur.1756 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

A new test of advanced theory of mind: The “Strange Stories Film Task” captures social processing differences in adults with autism spectrum disorders / Kim MURRAY in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1120-1132 Titre : A new test of advanced theory of mind: The “Strange Stories Film Task” captures social processing differences in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Kim MURRAY, Auteur ; Kate JOHNSTON, Auteur ; Helen CUNNANE, Auteur ; Charlotte KERR, Auteur ; Debbie SPAIN, Auteur ; Nicola GILLAN, Auteur ; Neil HAMMOND, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1120-1132 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  adults  advanced theory of mind  social cognition  empathy  mentalising  alexithymia Index. décimale : PER Périodiques Résumé : Real-life social processing abilities of adults with autism spectrum disorders (ASD) can be hard to capture in lab-based experimental tasks. A novel measure of social cognition, the “Strange Stories Film task’ (SSFt), was designed to overcome limitations of available measures in the field. Brief films were made based on the scenarios from the Strange Stories task (Happé) and designed to capture the subtle social-cognitive difficulties observed in ASD adults. Twenty neurotypical adults were recruited to pilot the new measure. A final test set was produced and administered to a group of 20 adults with ASD and 20 matched controls, alongside established social cognition tasks and questionnaire measures of empathy, alexithymia and ASD traits. The SSFt was more effective than existing measures at differentiating the ASD group from the control group. In the ASD group, the SSFt was associated with the Strange Stories task. The SSFt is a potentially useful tool to identify social cognitive dis/abilities in ASD, with preliminary evidence of adequate convergent validity. Future research directions are discussed. En ligne : http://dx.doi.org/10.1002/aur.1744 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] A new test of advanced theory of mind: The “Strange Stories Film Task” captures social processing differences in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Kim MURRAY, Auteur ; Kate JOHNSTON, Auteur ; Helen CUNNANE, Auteur ; Charlotte KERR, Auteur ; Debbie SPAIN, Auteur ; Nicola GILLAN, Auteur ; Neil HAMMOND, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur . - p.1120-1132. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1120-1132 Mots-clés : autism spectrum disorder  adults  advanced theory of mind  social cognition  empathy  mentalising  alexithymia Index. décimale : PER Périodiques Résumé : Real-life social processing abilities of adults with autism spectrum disorders (ASD) can be hard to capture in lab-based experimental tasks. A novel measure of social cognition, the “Strange Stories Film task’ (SSFt), was designed to overcome limitations of available measures in the field. Brief films were made based on the scenarios from the Strange Stories task (Happé) and designed to capture the subtle social-cognitive difficulties observed in ASD adults. Twenty neurotypical adults were recruited to pilot the new measure. A final test set was produced and administered to a group of 20 adults with ASD and 20 matched controls, alongside established social cognition tasks and questionnaire measures of empathy, alexithymia and ASD traits. The SSFt was more effective than existing measures at differentiating the ASD group from the control group. In the ASD group, the SSFt was associated with the Strange Stories task. The SSFt is a potentially useful tool to identify social cognitive dis/abilities in ASD, with preliminary evidence of adequate convergent validity. Future research directions are discussed. En ligne : http://dx.doi.org/10.1002/aur.1744 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

A clinician-administered observation and corresponding caregiver interview capturing DSM-5 sensory reactivity symptoms in children with ASD / Paige M. SIPER in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1133-1140 Titre : A clinician-administered observation and corresponding caregiver interview capturing DSM-5 sensory reactivity symptoms in children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; A. Ting WANG, Auteur ; Joseph D. BUXBAUM, Auteur ; Teresa TAVASSOLI, Auteur Article en page(s) : p.1133-1140 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  sensory reactivity  sensory processing  assessment Index. décimale : PER Périodiques Résumé : Background: Sensory reactivity is a new criterion for autism spectrum disorder (ASD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). However, there is no consensus on how to reliably measure sensory reactivity, particularly in minimally verbal individuals. The current study is an initial validation of the Sensory Assessment for Neurodevelopmental Disorders (SAND), a novel clinician-administered observation and corresponding caregiver interview that captures sensory symptoms based on DSM-5 criteria for ASD. Methods: Eighty children between the ages of 2 and 12 participated in this study; 44 children with ASD and 36 typically developing (TD) children. Sensory reactivity symptoms were measured using the SAND and the already validated Short Sensory Profile (SSP). Initial psychometric properties of the SAND were examined including reliability, validity, sensitivity and specificity. Results: Children with ASD showed significantly more sensory reactivity symptoms compared to TD children across sensory domains (visual, tactile, and auditory) and within sensory subtypes (hyperreactivity, hyporeactivity and seeking). The SAND showed strong internal consistency, inter-rater reliability and test-retest reliability, high sensitivity (95.5%) and specificity (91.7%), and strong convergent validity with the SSP. Significance: The SAND provides a novel method to characterize sensory reactivity symptoms based on DSM-5 criteria for ASD. This is the first known sensory assessment that combines a clinician-administered observation and caregiver interview to optimally capture sensory phenotypes characteristic of individuals with neurodevelopmental disorders. The SAND offers a beneficial new tool for both research and clinical purposes and has the potential to meaningfully enhance gold-standard assessment of ASD. En ligne : http://dx.doi.org/10.1002/aur.1750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] A clinician-administered observation and corresponding caregiver interview capturing DSM-5 sensory reactivity symptoms in children with ASD [Texte imprimé et/ou numérique] / Paige M. SIPER, Auteur ; Alexander KOLEVZON, Auteur ; A. Ting WANG, Auteur ; Joseph D. BUXBAUM, Auteur ; Teresa TAVASSOLI, Auteur . - p.1133-1140. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1133-1140 Mots-clés : autism spectrum disorder  sensory reactivity  sensory processing  assessment Index. décimale : PER Périodiques Résumé : Background: Sensory reactivity is a new criterion for autism spectrum disorder (ASD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). However, there is no consensus on how to reliably measure sensory reactivity, particularly in minimally verbal individuals. The current study is an initial validation of the Sensory Assessment for Neurodevelopmental Disorders (SAND), a novel clinician-administered observation and corresponding caregiver interview that captures sensory symptoms based on DSM-5 criteria for ASD. Methods: Eighty children between the ages of 2 and 12 participated in this study; 44 children with ASD and 36 typically developing (TD) children. Sensory reactivity symptoms were measured using the SAND and the already validated Short Sensory Profile (SSP). Initial psychometric properties of the SAND were examined including reliability, validity, sensitivity and specificity. Results: Children with ASD showed significantly more sensory reactivity symptoms compared to TD children across sensory domains (visual, tactile, and auditory) and within sensory subtypes (hyperreactivity, hyporeactivity and seeking). The SAND showed strong internal consistency, inter-rater reliability and test-retest reliability, high sensitivity (95.5%) and specificity (91.7%), and strong convergent validity with the SSP. Significance: The SAND provides a novel method to characterize sensory reactivity symptoms based on DSM-5 criteria for ASD. This is the first known sensory assessment that combines a clinician-administered observation and caregiver interview to optimally capture sensory phenotypes characteristic of individuals with neurodevelopmental disorders. The SAND offers a beneficial new tool for both research and clinical purposes and has the potential to meaningfully enhance gold-standard assessment of ASD. En ligne : http://dx.doi.org/10.1002/aur.1750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Don't touch me! autistic traits modulate early and late ERP components during visual perception of social touch / Leehe PELED-AVRON in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1141-1154 Titre : Don't touch me! autistic traits modulate early and late ERP components during visual perception of social touch Type de document : Texte imprimé et/ou numérique Auteurs : Leehe PELED-AVRON, Auteur ; Simone G. SHAMAY-TSOORY, Auteur Article en page(s) : p.1141-1154 Langues : Anglais (eng) Mots-clés : autistic traits  interpersonal touch  ERP  LPP  P1 Index. décimale : PER Périodiques Résumé : Although individuals with autism spectrum disorder (ASD) have impaired responses to interpersonal touch, the underlying neural correlates remain largely unknown. Here, we examined the neural correlates that underlie interpersonal touch perception in individuals with either high or low autistic traits. Fifty-three participants were classified as having either high or low autistic traits based on their performance on the autism quotient (AQ) questionnaire. We hypothesized that individuals with high AQ scores would have relatively high touch hypervigilance, reflected as earlier P1 and stronger late positive potential (LPP) responses, two components of event-related potentials that serve as electrophysiological markers of anxiety bias. We recorded each participant's electroencephalography activity during presentation of images depicting human touch, object touch, and non-touch control images. Consistent with our hypothesis, AQ scores were positively correlated with social touch aversion. Moreover, participants with high AQ scores had earlier P1 and stronger LPP responses when presented with human touch compared to the control images. Importantly, a regression model revealed that earlier P1 and larger LPP amplitude measured during social touch observation can accurately predict higher autistic trait levels. Taken together, these findings indicate that individuals with high levels of autistic traits may have a hypervigilant response to observed social touch. En ligne : http://dx.doi.org/10.1002/aur.1762 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Don't touch me! autistic traits modulate early and late ERP components during visual perception of social touch [Texte imprimé et/ou numérique] / Leehe PELED-AVRON, Auteur ; Simone G. SHAMAY-TSOORY, Auteur . - p.1141-1154. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1141-1154 Mots-clés : autistic traits  interpersonal touch  ERP  LPP  P1 Index. décimale : PER Périodiques Résumé : Although individuals with autism spectrum disorder (ASD) have impaired responses to interpersonal touch, the underlying neural correlates remain largely unknown. Here, we examined the neural correlates that underlie interpersonal touch perception in individuals with either high or low autistic traits. Fifty-three participants were classified as having either high or low autistic traits based on their performance on the autism quotient (AQ) questionnaire. We hypothesized that individuals with high AQ scores would have relatively high touch hypervigilance, reflected as earlier P1 and stronger late positive potential (LPP) responses, two components of event-related potentials that serve as electrophysiological markers of anxiety bias. We recorded each participant's electroencephalography activity during presentation of images depicting human touch, object touch, and non-touch control images. Consistent with our hypothesis, AQ scores were positively correlated with social touch aversion. Moreover, participants with high AQ scores had earlier P1 and stronger LPP responses when presented with human touch compared to the control images. Importantly, a regression model revealed that earlier P1 and larger LPP amplitude measured during social touch observation can accurately predict higher autistic trait levels. Taken together, these findings indicate that individuals with high levels of autistic traits may have a hypervigilant response to observed social touch. En ligne : http://dx.doi.org/10.1002/aur.1762 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder / Chen CHEN in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1155-1162 Titre : Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chen CHEN, Auteur ; Yi-Dong SHEN, Auteur ; Guang-Lei XUN, Auteur ; Wei-Xiong CAI, Auteur ; Li-Juan SHI, Auteur ; Lu XIAO, Auteur ; Ren-Rong WU, Auteur ; Jing-Ping ZHAO, Auteur ; Jian-Jun OU, Auteur Article en page(s) : p.1155-1162 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  aggressive behaviors  treatable risk factors  sleep problems  ADHD symptoms Index. décimale : PER Périodiques Résumé : Aggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study. The Institute for Basic Research – Modified Overt Aggression Scale (IBR-MOAS) was used to assess aggressive behaviors. Children's social impairments, sleep problems and ADHD symptoms were also measured with specific scales. The total IBR-MOAS score was significantly higher (worse) in the TD group [4.47 (5.36)] than in the ASD group [3.47 (5.63), P?=?0.004]. The aggressive modes differed between groups: when compared with each other, the TD group received higher scores on Verbal and Physical Aggression Toward Others (all P? En ligne : http://dx.doi.org/10.1002/aur.1751 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder [Texte imprimé et/ou numérique] / Chen CHEN, Auteur ; Yi-Dong SHEN, Auteur ; Guang-Lei XUN, Auteur ; Wei-Xiong CAI, Auteur ; Li-Juan SHI, Auteur ; Lu XIAO, Auteur ; Ren-Rong WU, Auteur ; Jing-Ping ZHAO, Auteur ; Jian-Jun OU, Auteur . - p.1155-1162. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1155-1162 Mots-clés : autism spectrum disorder  aggressive behaviors  treatable risk factors  sleep problems  ADHD symptoms Index. décimale : PER Périodiques Résumé : Aggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study. The Institute for Basic Research – Modified Overt Aggression Scale (IBR-MOAS) was used to assess aggressive behaviors. Children's social impairments, sleep problems and ADHD symptoms were also measured with specific scales. The total IBR-MOAS score was significantly higher (worse) in the TD group [4.47 (5.36)] than in the ASD group [3.47 (5.63), P?=?0.004]. The aggressive modes differed between groups: when compared with each other, the TD group received higher scores on Verbal and Physical Aggression Toward Others (all P? En ligne : http://dx.doi.org/10.1002/aur.1751 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Relationship between early motor milestones and severity of restricted and repetitive behaviors in children and adolescents with autism spectrum disorder / Mirko ULJAREVIC in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1163-1168 Titre : Relationship between early motor milestones and severity of restricted and repetitive behaviors in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mirko ULJAREVIC, Auteur ; Darren HEDLEY, Auteur ; Gail A. ALVARES, Auteur ; Kandice J. VARCIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1163-1168 Langues : Anglais (eng) Mots-clés : repetitive behavior  motor milestones  atypical gait  autism Index. décimale : PER Périodiques Résumé : This study explored the relationships between the later age of achievement of early motor milestones, current motor atypicalities (toe walking), and the severity of restricted and repetitive behaviors (RRBs) in individuals with autism spectrum disorder (ASD). Parents of 147 children and adolescents with ASD (Mage?=?8.09 years, SD?=?4.28; 119 males) completed an early developmental milestones questionnaire and the Social Responsiveness Scale as a measure of Insistence on Sameness (IS) and Repetitive Mannerisms (RM). Two hierarchical regression analyses were conducted to test whether RM and IS behaviors were predicted by early motor milestones, or current toe walking. The final model predicting RM accounted for 15% of the variance (F?=?3.02, p?=?.009), with toe walking as a unique and independent predictor of RM scores (t?=?3.568, p?=?.001). The final model predicting IS accounted for 19.1% of variance in IS scores (F?=?4.045, p?=?.001), with chronological age (CA) (t?=?2.92, p?=?.004), age when first standing (t?=?2.09, p?=?.038), and toe walking (t?=?2.53, p?=?.013) as unique independent predictors. Toe walking (t?=?2.4, p?=?.018) and age when first sitting (t?=?2.08, p?=?.04) predicted the severity of RRBs on the Autism Diagnostic Observation Schedule (F?=?2.334, p?=?.036). Our study replicates previous findings on the relationship between concurrent motor impairments and RRBs, and provides the first evidence for the association between RRBs and age of attainment of early motor milestones. En ligne : http://dx.doi.org/10.1002/aur.1763 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Relationship between early motor milestones and severity of restricted and repetitive behaviors in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Mirko ULJAREVIC, Auteur ; Darren HEDLEY, Auteur ; Gail A. ALVARES, Auteur ; Kandice J. VARCIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1163-1168. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1163-1168 Mots-clés : repetitive behavior  motor milestones  atypical gait  autism Index. décimale : PER Périodiques Résumé : This study explored the relationships between the later age of achievement of early motor milestones, current motor atypicalities (toe walking), and the severity of restricted and repetitive behaviors (RRBs) in individuals with autism spectrum disorder (ASD). Parents of 147 children and adolescents with ASD (Mage?=?8.09 years, SD?=?4.28; 119 males) completed an early developmental milestones questionnaire and the Social Responsiveness Scale as a measure of Insistence on Sameness (IS) and Repetitive Mannerisms (RM). Two hierarchical regression analyses were conducted to test whether RM and IS behaviors were predicted by early motor milestones, or current toe walking. The final model predicting RM accounted for 15% of the variance (F?=?3.02, p?=?.009), with toe walking as a unique and independent predictor of RM scores (t?=?3.568, p?=?.001). The final model predicting IS accounted for 19.1% of variance in IS scores (F?=?4.045, p?=?.001), with chronological age (CA) (t?=?2.92, p?=?.004), age when first standing (t?=?2.09, p?=?.038), and toe walking (t?=?2.53, p?=?.013) as unique independent predictors. Toe walking (t?=?2.4, p?=?.018) and age when first sitting (t?=?2.08, p?=?.04) predicted the severity of RRBs on the Autism Diagnostic Observation Schedule (F?=?2.334, p?=?.036). Our study replicates previous findings on the relationship between concurrent motor impairments and RRBs, and provides the first evidence for the association between RRBs and age of attainment of early motor milestones. En ligne : http://dx.doi.org/10.1002/aur.1763 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Scientific Summaries for Families with ASD in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1169-1173 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1169-1173 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1825 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.1169-1173. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1169-1173 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1825 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

International Society for Autism Research News www.autism-insar.org in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1174-1175 Titre : International Society for Autism Research News www.autism-insar.org Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1174-1175 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1826 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] International Society for Autism Research News www.autism-insar.org [Texte imprimé et/ou numérique] . - p.1174-1175. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1174-1175 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1826 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309