Dépouillements

Traumatic Experiences, Psychological Distress and Suicide-Related Behaviors in Autistic Adults / T. A. CHIKAURA in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70137 Titre : Traumatic Experiences, Psychological Distress and Suicide-Related Behaviors in Autistic Adults Type de document : texte imprimé Auteurs : T. A. CHIKAURA, Auteur ; E. WEIR, Auteur ; S. GRIFFITHS, Auteur ; T. PROCYSHYN, Auteur ; M. PELTON, Auteur ; C. ALLISON, Auteur ; H. HODGES, Auteur ; S. R. WHITE, Auteur ; T. FORD, Auteur ; S. BARON-COHEN, Auteur Article en page(s) : p.e70137 Langues : Anglais (eng) Mots-clés : autism  mental health  self-harm  substance use  suicide attempts  suicide plans  trauma Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic adults have increased risks of trauma, suicide, and poor mental health compared to non-autistic adults, with 1 in 4 autistic adults attempting suicide. We administered an anonymized, self-report survey to 424 autistic and 345 non-autistic adults through a convenience sampling framework. Binomial logistic regression models identified whether trauma and autism diagnosis were related to (i) self-harm, (ii) suicide attempts, (iii) suicide plans, (iv) a mental health condition that impacts daily life, and (v) substance use to cope. Heatmaps were generated to identify traumas that frequently co-occur with psychological distress and SRB. After accounting for trauma and demographic differences, autism remained a significant predictor of all outcomes, except whether individuals used substances to cope (OR: 0.78, 95% CI: 0.54?1.12, p?=?0.18). Autistic people were more likely to report self-harm (OR: 2.71, 95% CI: 1.85?4.00, p? En ligne : https://doi.org/10.1002/aur.70137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Traumatic Experiences, Psychological Distress and Suicide-Related Behaviors in Autistic Adults [texte imprimé] / T. A. CHIKAURA, Auteur ; E. WEIR, Auteur ; S. GRIFFITHS, Auteur ; T. PROCYSHYN, Auteur ; M. PELTON, Auteur ; C. ALLISON, Auteur ; H. HODGES, Auteur ; S. R. WHITE, Auteur ; T. FORD, Auteur ; S. BARON-COHEN, Auteur . - p.e70137. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70137 Mots-clés : autism  mental health  self-harm  substance use  suicide attempts  suicide plans  trauma Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic adults have increased risks of trauma, suicide, and poor mental health compared to non-autistic adults, with 1 in 4 autistic adults attempting suicide. We administered an anonymized, self-report survey to 424 autistic and 345 non-autistic adults through a convenience sampling framework. Binomial logistic regression models identified whether trauma and autism diagnosis were related to (i) self-harm, (ii) suicide attempts, (iii) suicide plans, (iv) a mental health condition that impacts daily life, and (v) substance use to cope. Heatmaps were generated to identify traumas that frequently co-occur with psychological distress and SRB. After accounting for trauma and demographic differences, autism remained a significant predictor of all outcomes, except whether individuals used substances to cope (OR: 0.78, 95% CI: 0.54?1.12, p?=?0.18). Autistic people were more likely to report self-harm (OR: 2.71, 95% CI: 1.85?4.00, p? En ligne : https://doi.org/10.1002/aur.70137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Reduced Susceptibility to the Dunning–Kruger Effect in Autistic Employees / Lorne M. HARTMAN in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70139 Titre : Reduced Susceptibility to the Dunning–Kruger Effect in Autistic Employees Type de document : texte imprimé Auteurs : Lorne M. HARTMAN, Auteur ; Harley GLASSMAN, Auteur ; Braxton L. HARTMAN, Auteur Article en page(s) : p.e70139 Langues : Anglais (eng) Mots-clés : autism  cognitive bias  metacognitive awareness  neurodiversity Index. décimale : PER Périodiques Résumé : ABSTRACT Evidence indicates that autistic individuals are less susceptible to social influence and cognitive biases than non-autistic individuals. However, no studies have been conducted on the Dunning?Kruger effect (DKE) in autism. The DKE is a cognitive bias in which people with limited expertise in a specific domain overestimate their abilities. The purpose of this study is to compare autistic and non-autistic employees' self-assessments of their performance with their objective performance on a popular performance-based measure of analytic thinking disposition, the CRT (cognitive reflection test). After completing the task, no feedback or clues were provided regarding how well they performed. Participants were then asked to estimate how many questions they answered correctly and compare their performance to other participants by estimating the percentage of peers they outperformed. Results indicated asymmetric calibration of actual versus estimated CRT performance in autistic employees: In the low-performance group, autistic participants overestimated their abilities less than non-autistic participants. However, in the high-performance group, autistic participants underestimated their abilities more than non-autistic participants. Reduced susceptibility to the DKE highlights potential benefits of autistic employees in the workplace. Theoretical and practical implications consider the intersection of metacognitive awareness, autism, and the DKE in an organizational context. En ligne : https://doi.org/10.1002/aur.70139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Reduced Susceptibility to the Dunning–Kruger Effect in Autistic Employees [texte imprimé] / Lorne M. HARTMAN, Auteur ; Harley GLASSMAN, Auteur ; Braxton L. HARTMAN, Auteur . - p.e70139. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70139 Mots-clés : autism  cognitive bias  metacognitive awareness  neurodiversity Index. décimale : PER Périodiques Résumé : ABSTRACT Evidence indicates that autistic individuals are less susceptible to social influence and cognitive biases than non-autistic individuals. However, no studies have been conducted on the Dunning?Kruger effect (DKE) in autism. The DKE is a cognitive bias in which people with limited expertise in a specific domain overestimate their abilities. The purpose of this study is to compare autistic and non-autistic employees' self-assessments of their performance with their objective performance on a popular performance-based measure of analytic thinking disposition, the CRT (cognitive reflection test). After completing the task, no feedback or clues were provided regarding how well they performed. Participants were then asked to estimate how many questions they answered correctly and compare their performance to other participants by estimating the percentage of peers they outperformed. Results indicated asymmetric calibration of actual versus estimated CRT performance in autistic employees: In the low-performance group, autistic participants overestimated their abilities less than non-autistic participants. However, in the high-performance group, autistic participants underestimated their abilities more than non-autistic participants. Reduced susceptibility to the DKE highlights potential benefits of autistic employees in the workplace. Theoretical and practical implications consider the intersection of metacognitive awareness, autism, and the DKE in an organizational context. En ligne : https://doi.org/10.1002/aur.70139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Factor Structure of the Sleep Disturbance Scale for Children in a Cohort of Youth With Autism / Emma K. BAKER in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70140 Titre : Factor Structure of the Sleep Disturbance Scale for Children in a Cohort of Youth With Autism Type de document : texte imprimé Auteurs : Emma K. BAKER, Auteur ; Emily SPACKMAN, Auteur ; Lacey CHETCUTI, Auteur ; Amanda L. RICHDALE, Auteur ; Joachim HALLMAYER, Auteur ; Michael GRADISAR, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVIĆ, Auteur Article en page(s) : p.e70140 Langues : Anglais (eng) Mots-clés : assessment  autism  factor analysis  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Despite the substantial evidence base for poor sleep in autism, sleep problems are frequently under-identified and inefficiently managed. This is, in part, due to the fact that available tools do not comprehensively capture the specific sleep phenotypes in autism. The Sleep Disturbance Scale for Children (SDSC) is one of the highest ranked pediatric sleep assessment tools, yet it is scarcely used in autism research. Consequently, the utility of the SDSC for characterizing sleep disturbances in autism remains unknown. This study explored the factor structure of the SDSC in a sample of 513 autistic youth, aged 3?18?years (mean: 10.5?years; SD: 3.7; 18.7% female) drawn from the Healthy Brain Network secondary dataset. Fit of the previously derived SDSC factor structure was appraised using the confirmatory application of the exploratory structural equation modeling. Results indicated a five-factor solution comprising disorders of initiating and maintaining sleep, disorders of arousal, disorders of excessive somnolence (DoES), sleep breathing disorders, and sleep?wake transition disorders (SWTD) provided an excellent fit for the data. The derived factor solution was stable across sex and age. Notably, all sleep subscales were significantly positively associated with internalizing and externalizing behaviors, while age was significantly associated with DoES (r?=?0.15) and SWTD (r?=??0.18). This study provides the first validation of the SDSC in a large sample of well-characterized autistic youth showing distinct patterns of associations with key clinical correlates. Findings are consistent with independent reviews, suggesting the SDSC may provide a more effective way to screen for sleep disturbances in autistic individuals. En ligne : https://doi.org/10.1002/aur.70140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Factor Structure of the Sleep Disturbance Scale for Children in a Cohort of Youth With Autism [texte imprimé] / Emma K. BAKER, Auteur ; Emily SPACKMAN, Auteur ; Lacey CHETCUTI, Auteur ; Amanda L. RICHDALE, Auteur ; Joachim HALLMAYER, Auteur ; Michael GRADISAR, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVIĆ, Auteur . - p.e70140. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70140 Mots-clés : assessment  autism  factor analysis  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Despite the substantial evidence base for poor sleep in autism, sleep problems are frequently under-identified and inefficiently managed. This is, in part, due to the fact that available tools do not comprehensively capture the specific sleep phenotypes in autism. The Sleep Disturbance Scale for Children (SDSC) is one of the highest ranked pediatric sleep assessment tools, yet it is scarcely used in autism research. Consequently, the utility of the SDSC for characterizing sleep disturbances in autism remains unknown. This study explored the factor structure of the SDSC in a sample of 513 autistic youth, aged 3?18?years (mean: 10.5?years; SD: 3.7; 18.7% female) drawn from the Healthy Brain Network secondary dataset. Fit of the previously derived SDSC factor structure was appraised using the confirmatory application of the exploratory structural equation modeling. Results indicated a five-factor solution comprising disorders of initiating and maintaining sleep, disorders of arousal, disorders of excessive somnolence (DoES), sleep breathing disorders, and sleep?wake transition disorders (SWTD) provided an excellent fit for the data. The derived factor solution was stable across sex and age. Notably, all sleep subscales were significantly positively associated with internalizing and externalizing behaviors, while age was significantly associated with DoES (r?=?0.15) and SWTD (r?=??0.18). This study provides the first validation of the SDSC in a large sample of well-characterized autistic youth showing distinct patterns of associations with key clinical correlates. Findings are consistent with independent reviews, suggesting the SDSC may provide a more effective way to screen for sleep disturbances in autistic individuals. En ligne : https://doi.org/10.1002/aur.70140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Gender Identity Profiles in Autistic and Non-Autistic Cisgender and Gender Diverse Youth, and Their Caregivers / Matthew C. FYSH in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70142 Titre : Gender Identity Profiles in Autistic and Non-Autistic Cisgender and Gender Diverse Youth, and Their Caregivers Type de document : texte imprimé Auteurs : Matthew C. FYSH, Auteur ; Aimilia KALLITSOUNAKI, Auteur ; David M. WILLIAMS, Auteur ; Eilis KENNEDY, Auteur ; Lauren SPINNER, Auteur Article en page(s) : p.e70142 Langues : Anglais (eng) Mots-clés : autism disorder  caregivers  family  gender dysphoria  gender identity  phenotype Index. décimale : PER Périodiques Résumé : ABSTRACT This preregistered study examined whether the gender identity phenotype differs between autistic and non-autistic children and adolescents, as well as whether gender identity traits aggregate similarly within their families. Study 1 involved four matched groups of autistic and non-autistic gender diverse youth referred to a UK specialist gender clinic, as well as cisgender autistic and non-autistic youth (n?=?45 per group). Participants completed measures of gender typicality, discontentedness, anticipated future identity, and (parent-reported) dysphoria. Despite large and significant differences between cisgender and gender diverse youth across all gender-related measures, there were no significant differences between autistic and non-autistic participants within either gender group. Study 2 assessed recalled childhood gender behaviors and current gender dysphoria in the caregivers of participants from each group (N?=?203). Caregivers of gender-referred youth, regardless of autism status, reported higher current dysphoric traits than caregivers of cisgender youth, but no differences were observed in recalled childhood gender-related behavior. Overall, the findings indicate that the gender phenotype of autistic youth is comparable to that of non-autistic youth within the same gender identity group, challenging the assumption that gender diversity in autism arises from different underlying mechanisms. Clinically, these results support equitable access to gender-related care for autistic and non-autistic gender diverse youth. En ligne : https://doi.org/10.1002/aur.70142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Gender Identity Profiles in Autistic and Non-Autistic Cisgender and Gender Diverse Youth, and Their Caregivers [texte imprimé] / Matthew C. FYSH, Auteur ; Aimilia KALLITSOUNAKI, Auteur ; David M. WILLIAMS, Auteur ; Eilis KENNEDY, Auteur ; Lauren SPINNER, Auteur . - p.e70142. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70142 Mots-clés : autism disorder  caregivers  family  gender dysphoria  gender identity  phenotype Index. décimale : PER Périodiques Résumé : ABSTRACT This preregistered study examined whether the gender identity phenotype differs between autistic and non-autistic children and adolescents, as well as whether gender identity traits aggregate similarly within their families. Study 1 involved four matched groups of autistic and non-autistic gender diverse youth referred to a UK specialist gender clinic, as well as cisgender autistic and non-autistic youth (n?=?45 per group). Participants completed measures of gender typicality, discontentedness, anticipated future identity, and (parent-reported) dysphoria. Despite large and significant differences between cisgender and gender diverse youth across all gender-related measures, there were no significant differences between autistic and non-autistic participants within either gender group. Study 2 assessed recalled childhood gender behaviors and current gender dysphoria in the caregivers of participants from each group (N?=?203). Caregivers of gender-referred youth, regardless of autism status, reported higher current dysphoric traits than caregivers of cisgender youth, but no differences were observed in recalled childhood gender-related behavior. Overall, the findings indicate that the gender phenotype of autistic youth is comparable to that of non-autistic youth within the same gender identity group, challenging the assumption that gender diversity in autism arises from different underlying mechanisms. Clinically, these results support equitable access to gender-related care for autistic and non-autistic gender diverse youth. En ligne : https://doi.org/10.1002/aur.70142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study / Shane CLEARY in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70143 Titre : Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study Type de document : texte imprimé Auteurs : Shane CLEARY, Auteur ; Sarah ASBURY, Auteur ; Russell J. SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Rosanna WEKSBERG, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammad AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jane A. FOSTER, Auteur Article en page(s) : p.e70143 Langues : Anglais (eng) Mots-clés : attention deficit hyperactivity disorder  autism spectrum disorder  based on MeSH terms  behavioral phenotypes  cluster analysis  gastrointestinal symptoms  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : ABSTRACT Neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), have heterogeneous behavioral phenotypes and substantial symptom overlap. Identifying transdiagnostic subgroups may help clarify this heterogeneity. This study aimed to identify behavior-based subgroups of children with NDD and explore links between gastrointestinal (GI) symptoms and behavioral symptoms. Using data from the Province of Ontario Neurodevelopmental Disorders (POND) network, we applied a heterogeneous mixture model (HMM) to behavioral data from 1716 participants, including typically developing (TD, n?=?210), ASD (n?=?747), and ADHD (n?=?759) and identified six distinct clusters. Five of the clusters included individuals with TD, ADHD, and ASD diagnoses. The remaining cluster exhibited the most severe behavior phenotype and was exclusively ADHD and ASD participants. Notably, GI symptoms were significantly more prevalent in the cluster with the most severe behavioral profile (?2 (5)?=?64.4, p? En ligne : https://doi.org/10.1002/aur.70143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study [texte imprimé] / Shane CLEARY, Auteur ; Sarah ASBURY, Auteur ; Russell J. SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Rosanna WEKSBERG, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammad AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jane A. FOSTER, Auteur . - p.e70143. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70143 Mots-clés : attention deficit hyperactivity disorder  autism spectrum disorder  based on MeSH terms  behavioral phenotypes  cluster analysis  gastrointestinal symptoms  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : ABSTRACT Neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), have heterogeneous behavioral phenotypes and substantial symptom overlap. Identifying transdiagnostic subgroups may help clarify this heterogeneity. This study aimed to identify behavior-based subgroups of children with NDD and explore links between gastrointestinal (GI) symptoms and behavioral symptoms. Using data from the Province of Ontario Neurodevelopmental Disorders (POND) network, we applied a heterogeneous mixture model (HMM) to behavioral data from 1716 participants, including typically developing (TD, n?=?210), ASD (n?=?747), and ADHD (n?=?759) and identified six distinct clusters. Five of the clusters included individuals with TD, ADHD, and ASD diagnoses. The remaining cluster exhibited the most severe behavior phenotype and was exclusively ADHD and ASD participants. Notably, GI symptoms were significantly more prevalent in the cluster with the most severe behavioral profile (?2 (5)?=?64.4, p? En ligne : https://doi.org/10.1002/aur.70143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

A Preliminary Investigation of Dopamine Transporter Binding Abnormalities in Individuals With Autism Spectrum Disorder / Nanan NURAINI in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70144 Titre : A Preliminary Investigation of Dopamine Transporter Binding Abnormalities in Individuals With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Nanan NURAINI, Auteur ; Carrina APPLING, Auteur ; Bradley J. FERGUSON, Auteur ; Amolak SINGH, Auteur ; Amanda Moffitt GUNN, Auteur ; Roopa BHAT, Auteur ; Frank SCHRAML, Auteur ; B. Blair BRADEN, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.e70144 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT In the emerging literature on aging and autism, a consistently replicated finding is a significantly increased risk for Parkinson's disease (PD), up to six times higher. Also, atypical dopamine activity has been observed in autistic individuals and animal models. The only FDA-approved medications for ASD are the atypical antipsychotic medications, which inhibit postsynaptic dopaminergic and serotonergic transmission to treat irritability. Studies using resting state functional magnetic resonance imaging (rsfMRI) show disruption in striatal circuits in ASD. However, no studies have examined the striatal PD biomarker with dopamine transporter (DaT) single photon emission computed tomography (SPECT) imaging in adults with ASD. In this pilot study, we aimed to evaluate DaT SPECT in 18?24-year-old individuals with ASD and perform a pilot investigation of functional connectivity (FC) between the striatum and other brain areas. Four of the 12 participants had definite abnormalities or possible abnormalities in striatal DaT uptake. Participants were then separated into abnormal and normal DaT groups. In the exploratory analysis, the abnormal DaT group showed greater striatal FC to the paracingulate region compared with the normal DaT group. These pilot findings should be cautiously interpreted. Larger studies are needed to explore their link to behavioral outcomes and potential in predicting treatment responses. Examining how these findings evolve with age is also crucial, given evidence of the heightened risk of PD in ASD. En ligne : https://doi.org/10.1002/aur.70144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] A Preliminary Investigation of Dopamine Transporter Binding Abnormalities in Individuals With Autism Spectrum Disorder [texte imprimé] / Nanan NURAINI, Auteur ; Carrina APPLING, Auteur ; Bradley J. FERGUSON, Auteur ; Amolak SINGH, Auteur ; Amanda Moffitt GUNN, Auteur ; Roopa BHAT, Auteur ; Frank SCHRAML, Auteur ; B. Blair BRADEN, Auteur ; David Q. BEVERSDORF, Auteur . - p.e70144. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70144 Index. décimale : PER Périodiques Résumé : ABSTRACT In the emerging literature on aging and autism, a consistently replicated finding is a significantly increased risk for Parkinson's disease (PD), up to six times higher. Also, atypical dopamine activity has been observed in autistic individuals and animal models. The only FDA-approved medications for ASD are the atypical antipsychotic medications, which inhibit postsynaptic dopaminergic and serotonergic transmission to treat irritability. Studies using resting state functional magnetic resonance imaging (rsfMRI) show disruption in striatal circuits in ASD. However, no studies have examined the striatal PD biomarker with dopamine transporter (DaT) single photon emission computed tomography (SPECT) imaging in adults with ASD. In this pilot study, we aimed to evaluate DaT SPECT in 18?24-year-old individuals with ASD and perform a pilot investigation of functional connectivity (FC) between the striatum and other brain areas. Four of the 12 participants had definite abnormalities or possible abnormalities in striatal DaT uptake. Participants were then separated into abnormal and normal DaT groups. In the exploratory analysis, the abnormal DaT group showed greater striatal FC to the paracingulate region compared with the normal DaT group. These pilot findings should be cautiously interpreted. Larger studies are needed to explore their link to behavioral outcomes and potential in predicting treatment responses. Examining how these findings evolve with age is also crucial, given evidence of the heightened risk of PD in ASD. En ligne : https://doi.org/10.1002/aur.70144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Exploring Pragmatic Abilities in Sisters of Autistic Individuals: A Methodological Solution to Female Autism Research / Marie BELENGER in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70147 Titre : Exploring Pragmatic Abilities in Sisters of Autistic Individuals: A Methodological Solution to Female Autism Research Type de document : texte imprimé Auteurs : Marie BELENGER, Auteur ; Charlotte DUMONT, Auteur ; Mikhail KISSINE, Auteur Article en page(s) : p.e70147 Langues : Anglais (eng) Mots-clés : adolescence  pragmatics  sex differences  sisters Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is more frequently diagnosed in males than females. One possible explanation for this discrepancy is that autistic females may be overlooked because they show different, subtler signs of autism. For example, sex differences have been reported in pragmatic abilities. However, studying these sex differences is challenging, because diagnosed autistic females may not represent all autistic females?many remaining undiagnosed. To address this issue, our study included adolescent females at increased likelihood for autism: sisters of autistic individuals. Adolescence is a key period when autism-related difficulties often become more visible. We compared the pragmatic abilities of 76 female participants aged between 9 and 16?years old across three groups: autistic, nonautistic, and sisters of diagnosed autistic individuals. Participants completed a semistructured, spoken narrative task, which was analyzed for coherence and fluency. Their caregivers completed several questionnaires to assess both pragmatic abilities and global difficulties. At the group level, caregiver reports indicated an in-between position for sisters: they experienced more pragmatic-related difficulties than nonautistic participants but fewer than autistic participants. Narratives revealed no differences between sisters and nonautistic participants, with one exception: they gave fewer causal explanations of characters' mental states. Individual profiles of sisters revealed a heterogeneous group, varying from no difficulties at all to pragmatic profiles closely resembling those of autistic females. En ligne : https://doi.org/10.1002/aur.70147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Exploring Pragmatic Abilities in Sisters of Autistic Individuals: A Methodological Solution to Female Autism Research [texte imprimé] / Marie BELENGER, Auteur ; Charlotte DUMONT, Auteur ; Mikhail KISSINE, Auteur . - p.e70147. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70147 Mots-clés : adolescence  pragmatics  sex differences  sisters Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is more frequently diagnosed in males than females. One possible explanation for this discrepancy is that autistic females may be overlooked because they show different, subtler signs of autism. For example, sex differences have been reported in pragmatic abilities. However, studying these sex differences is challenging, because diagnosed autistic females may not represent all autistic females?many remaining undiagnosed. To address this issue, our study included adolescent females at increased likelihood for autism: sisters of autistic individuals. Adolescence is a key period when autism-related difficulties often become more visible. We compared the pragmatic abilities of 76 female participants aged between 9 and 16?years old across three groups: autistic, nonautistic, and sisters of diagnosed autistic individuals. Participants completed a semistructured, spoken narrative task, which was analyzed for coherence and fluency. Their caregivers completed several questionnaires to assess both pragmatic abilities and global difficulties. At the group level, caregiver reports indicated an in-between position for sisters: they experienced more pragmatic-related difficulties than nonautistic participants but fewer than autistic participants. Narratives revealed no differences between sisters and nonautistic participants, with one exception: they gave fewer causal explanations of characters' mental states. Individual profiles of sisters revealed a heterogeneous group, varying from no difficulties at all to pragmatic profiles closely resembling those of autistic females. En ligne : https://doi.org/10.1002/aur.70147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Psychiatric Emergency Visits of Autistic Adults With or Without Documented Borderline Personality Disorder / Ching-Hua Julie LEE in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70148 Titre : Psychiatric Emergency Visits of Autistic Adults With or Without Documented Borderline Personality Disorder Type de document : texte imprimé Auteurs : Ching-Hua Julie LEE, Auteur ; Louisa Lok Yee MAN, Auteur ; Alexandra MORRA, Auteur ; Carleigh PACE-TONNA, Auteur ; Chantelle CASTELINO, Auteur ; Valérie COURCHESNE, Auteur ; Margot FRAYNE, Auteur ; Vanessa LUK, Auteur ; Paria BAHARIKHOOB, Auteur ; Patrick JACHYRA, Auteur ; Juveria ZAHEER, Auteur ; Stephanie H. AMEIS, Auteur ; Hsiang-Yuan LIN, Auteur ; Amanda SAWYER, Auteur ; Yona LUNSKY, Auteur ; Meng-Chuan LAI, Auteur Article en page(s) : p.e70148 Langues : Anglais (eng) Mots-clés : autism  borderline personality disorder  psychiatric emergency department  sex  suicidality Index. décimale : PER Périodiques Résumé : ABSTRACT Autism and borderline personality disorder (BPD) are each associated with increased psychiatric emergency department (PsyED) use, yet the service impact of coexisting autism?BPD remains unclear. We conducted a retrospective chart review of 1027 PsyED visits by 345 autistic adults (2018?2020) at an urban Canadian psychiatric hospital to compare service patterns between those with and without a BPD diagnosis. Sociodemographics, presenting reasons, restraint use, and disposition were analyzed using mixed-effects logistic regression. BPD was documented in 33.5% of visits and in 11.0% of unique autistic individuals, more often in birth-assigned females. Among all autistic individuals' PsyED visits, an autism diagnosis was documented in 60.2% of their text-based charts. Furthermore, autism was documented less frequently when BPD was recorded, suggesting possible diagnostic overshadowing. Suicidality as the primary reason for visit was associated with documented BPD (OR 4.366, 95% CI 2.659?7.169; p? En ligne : https://doi.org/10.1002/aur.70148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Psychiatric Emergency Visits of Autistic Adults With or Without Documented Borderline Personality Disorder [texte imprimé] / Ching-Hua Julie LEE, Auteur ; Louisa Lok Yee MAN, Auteur ; Alexandra MORRA, Auteur ; Carleigh PACE-TONNA, Auteur ; Chantelle CASTELINO, Auteur ; Valérie COURCHESNE, Auteur ; Margot FRAYNE, Auteur ; Vanessa LUK, Auteur ; Paria BAHARIKHOOB, Auteur ; Patrick JACHYRA, Auteur ; Juveria ZAHEER, Auteur ; Stephanie H. AMEIS, Auteur ; Hsiang-Yuan LIN, Auteur ; Amanda SAWYER, Auteur ; Yona LUNSKY, Auteur ; Meng-Chuan LAI, Auteur . - p.e70148. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70148 Mots-clés : autism  borderline personality disorder  psychiatric emergency department  sex  suicidality Index. décimale : PER Périodiques Résumé : ABSTRACT Autism and borderline personality disorder (BPD) are each associated with increased psychiatric emergency department (PsyED) use, yet the service impact of coexisting autism?BPD remains unclear. We conducted a retrospective chart review of 1027 PsyED visits by 345 autistic adults (2018?2020) at an urban Canadian psychiatric hospital to compare service patterns between those with and without a BPD diagnosis. Sociodemographics, presenting reasons, restraint use, and disposition were analyzed using mixed-effects logistic regression. BPD was documented in 33.5% of visits and in 11.0% of unique autistic individuals, more often in birth-assigned females. Among all autistic individuals' PsyED visits, an autism diagnosis was documented in 60.2% of their text-based charts. Furthermore, autism was documented less frequently when BPD was recorded, suggesting possible diagnostic overshadowing. Suicidality as the primary reason for visit was associated with documented BPD (OR 4.366, 95% CI 2.659?7.169; p? En ligne : https://doi.org/10.1002/aur.70148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility / Dorit MÖHRLE in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70152 Titre : Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility Type de document : texte imprimé Auteurs : Dorit MÖHRLE, Auteur ; Demi MA, Auteur ; Wenyue XUE, Auteur ; Jun YAN, Auteur ; Ning CHENG, Auteur Article en page(s) : p.e70152 Langues : Anglais (eng) Mots-clés : audiogenic seizures  auditory pathways  Fmr1 knockout  fragile X syndrome  mice  neurodevelopmental disorders  sensory overload Index. décimale : PER Périodiques Résumé : ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability. In the brainstem, FMRP is necessary for normal development of acoustic reactivity, and its loss has been implicated in audiogenic seizures (AGS) in Fmr1 knockout (KO) mice, modeling auditory hypersensitivity and seizures in FXS patients. The present study investigated the correlation between auditory brainstem function and behavioral expression of AGS at the early (postnatal day P20, infancy) and late (P32, juvenile) stages of auditory development in Fmr1 KO mice compared with wildtype (WT) mice, and in both females and males. We tested responsiveness to pure tones of select auditory pathway elements through auditory brainstem responses, and neural synchronization to amplitude envelopes of modulated acoustic stimuli through auditory steady-state responses. AGS behavior was categorized for severity during 5-min exposure to loud sound. Expression of the immediate early gene cFos was quantified as a marker for neuronal activity in the inferior colliculus. During infancy, more severe AGS expression in Fmr1 KO mice compared with WT mice was accompanied by increased responsiveness to acoustic stimuli at the level of the superior olivary complex and inferior colliculus, and stronger neural synchronicity in subcortical auditory neurons. Fmr1 KO mice also had higher cFos positive cell counts in the inferior colliculus after exposure to loud sound. With age, both AGS susceptibility and exaggerated acoustic stimulus-evoked activity in the Fmr1 KO mice subsided. Intriguingly, Fmr1 KO mice displayed an altered developmental profile in both the threshold and amplitude of auditory brainstem response. Our findings support evidence that AGS activity relies upon hyperexcitability in the auditory system, including in the lower brainstem, possibly due to disturbed auditory maturation. Hyper-synchronization to modulated sounds in subcortical auditory neurons seemed to predict AGS severity. The developmental trajectory of the auditory hyperresponsiveness and hypersynchrony suggests a transient processing alteration underlying heightened AGS susceptibility in Fmr1 KO mice. A better understanding of FXS-related circuit and behavioral symptoms of auditory processing across development provides the potential to identify therapeutic strategies to achieve auditory function recovery in FXS. En ligne : https://doi.org/10.1002/aur.70152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility [texte imprimé] / Dorit MÖHRLE, Auteur ; Demi MA, Auteur ; Wenyue XUE, Auteur ; Jun YAN, Auteur ; Ning CHENG, Auteur . - p.e70152. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70152 Mots-clés : audiogenic seizures  auditory pathways  Fmr1 knockout  fragile X syndrome  mice  neurodevelopmental disorders  sensory overload Index. décimale : PER Périodiques Résumé : ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability. In the brainstem, FMRP is necessary for normal development of acoustic reactivity, and its loss has been implicated in audiogenic seizures (AGS) in Fmr1 knockout (KO) mice, modeling auditory hypersensitivity and seizures in FXS patients. The present study investigated the correlation between auditory brainstem function and behavioral expression of AGS at the early (postnatal day P20, infancy) and late (P32, juvenile) stages of auditory development in Fmr1 KO mice compared with wildtype (WT) mice, and in both females and males. We tested responsiveness to pure tones of select auditory pathway elements through auditory brainstem responses, and neural synchronization to amplitude envelopes of modulated acoustic stimuli through auditory steady-state responses. AGS behavior was categorized for severity during 5-min exposure to loud sound. Expression of the immediate early gene cFos was quantified as a marker for neuronal activity in the inferior colliculus. During infancy, more severe AGS expression in Fmr1 KO mice compared with WT mice was accompanied by increased responsiveness to acoustic stimuli at the level of the superior olivary complex and inferior colliculus, and stronger neural synchronicity in subcortical auditory neurons. Fmr1 KO mice also had higher cFos positive cell counts in the inferior colliculus after exposure to loud sound. With age, both AGS susceptibility and exaggerated acoustic stimulus-evoked activity in the Fmr1 KO mice subsided. Intriguingly, Fmr1 KO mice displayed an altered developmental profile in both the threshold and amplitude of auditory brainstem response. Our findings support evidence that AGS activity relies upon hyperexcitability in the auditory system, including in the lower brainstem, possibly due to disturbed auditory maturation. Hyper-synchronization to modulated sounds in subcortical auditory neurons seemed to predict AGS severity. The developmental trajectory of the auditory hyperresponsiveness and hypersynchrony suggests a transient processing alteration underlying heightened AGS susceptibility in Fmr1 KO mice. A better understanding of FXS-related circuit and behavioral symptoms of auditory processing across development provides the potential to identify therapeutic strategies to achieve auditory function recovery in FXS. En ligne : https://doi.org/10.1002/aur.70152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People / Bethany OAKLEY in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70153 Titre : Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People Type de document : texte imprimé Auteurs : Bethany OAKLEY, Auteur ; Charlotte A. BOATMAN, Auteur ; Saffron BALDOZA, Auteur ; Amy HEARN, Auteur ; Colin LARKWORTHY, Auteur ; Rachel KENT, Auteur ; Ann OZSIVADJIAN, Auteur ; Sophie DOSWELL, Auteur ; Antonia DITTNER, Auteur ; Amanda ROESTORF, Auteur ; Dhara RAWAL, Auteur ; Ben CARTER, Auteur ; Emily SIMONOFF, Auteur ; Group THE MOLEHILL MOUNTAIN ADVISORY, Auteur Article en page(s) : p.e70153 Langues : Anglais (eng) Mots-clés : anxiety  autism  CBT  digital tools  intervention  mental health  mHealth Index. décimale : PER Périodiques Résumé : ABSTRACT At least 50% of autistic people experience clinically relevant anxiety symptoms. However, reasons for elevated rates of anxiety in autism remain poorly understood and there is a high unmet need for novel and adapted therapies for anxiety that are accessible to autistic people. This study aimed to establish the feasibility of a novel app-based anxiety management tool (?Molehill Mountain?) that has been developed with, and adapted for, autistic people. A single-centre, single-arm feasibility study design was employed, whereby autistic people (≥?16?years) with mild-to-severe symptoms of anxiety were recruited to a 13-week intervention period (King's College London, UK; clinicaltrials.gov identifier NCT05302167). Of 123 prospective participants screened, 100 (81%) participants aged 16?74?years (n?=?69 female) were enrolled within approximately 15 months. n?=?76 (76%) completed an anxiety measure at ~15?weeks (Generalized Anxiety Disorder?7 Item Scale; GAD-7). Most adhered to the full intervention duration: 65% (n?=?47), with most using the app weekly (1?6?days per week; 58%). 73% of participants agreed that they found the app easy to use overall and that an app is a good format for offering anxiety support to autistic people. There was a significant reduction in self-reported anxiety symptom severity with mean difference 2.88 (95% CI 1.88, 3.89; p? En ligne : https://doi.org/10.1002/aur.70153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People [texte imprimé] / Bethany OAKLEY, Auteur ; Charlotte A. BOATMAN, Auteur ; Saffron BALDOZA, Auteur ; Amy HEARN, Auteur ; Colin LARKWORTHY, Auteur ; Rachel KENT, Auteur ; Ann OZSIVADJIAN, Auteur ; Sophie DOSWELL, Auteur ; Antonia DITTNER, Auteur ; Amanda ROESTORF, Auteur ; Dhara RAWAL, Auteur ; Ben CARTER, Auteur ; Emily SIMONOFF, Auteur ; Group THE MOLEHILL MOUNTAIN ADVISORY, Auteur . - p.e70153. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70153 Mots-clés : anxiety  autism  CBT  digital tools  intervention  mental health  mHealth Index. décimale : PER Périodiques Résumé : ABSTRACT At least 50% of autistic people experience clinically relevant anxiety symptoms. However, reasons for elevated rates of anxiety in autism remain poorly understood and there is a high unmet need for novel and adapted therapies for anxiety that are accessible to autistic people. This study aimed to establish the feasibility of a novel app-based anxiety management tool (?Molehill Mountain?) that has been developed with, and adapted for, autistic people. A single-centre, single-arm feasibility study design was employed, whereby autistic people (≥?16?years) with mild-to-severe symptoms of anxiety were recruited to a 13-week intervention period (King's College London, UK; clinicaltrials.gov identifier NCT05302167). Of 123 prospective participants screened, 100 (81%) participants aged 16?74?years (n?=?69 female) were enrolled within approximately 15 months. n?=?76 (76%) completed an anxiety measure at ~15?weeks (Generalized Anxiety Disorder?7 Item Scale; GAD-7). Most adhered to the full intervention duration: 65% (n?=?47), with most using the app weekly (1?6?days per week; 58%). 73% of participants agreed that they found the app easy to use overall and that an app is a good format for offering anxiety support to autistic people. There was a significant reduction in self-reported anxiety symptom severity with mean difference 2.88 (95% CI 1.88, 3.89; p? En ligne : https://doi.org/10.1002/aur.70153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Single-Cell Transcriptome Meta-Analysis Reveals Epigenomic and Chromatin Dysregulation in Developing Neurons Derived From Human ESCs With 1q21.1 CNVs / Kosuke TORIGATA in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70156 Titre : Single-Cell Transcriptome Meta-Analysis Reveals Epigenomic and Chromatin Dysregulation in Developing Neurons Derived From Human ESCs With 1q21.1 CNVs Type de document : texte imprimé Auteurs : Kosuke TORIGATA, Auteur ; Jun NOMURA, Auteur ; Toru TAKUMI, Auteur Article en page(s) : p.e70156 Langues : Anglais (eng) Mots-clés : chromatin  copy number variation  epigenome  human ES cell  single-cell transcriptome Index. décimale : PER Périodiques Résumé : ABSTRACT Recent efforts to construct disease-specific multimodal omics databases at single-cell resolution, along with advances in reconstructive technologies such as brain organoids, have opened up opportunities to elucidate the molecular basis of complex human neuropsychiatric diseases. In this study, we performed a meta-analysis to characterize disease-associated regulatory modules by performing single-cell transcriptome analysis of developing neurons from reciprocal human ESC models of CNV in the distal 1q21.1 region. As a result, we observed significant directional enrichment of a series of genes in neuronal cells associated with autism spectrum disorder (ASD), bipolar disorder, and schizophrenia. Correlation analyses revealed that the disease-associated signature primarily targeted epigenetic regulatory mechanisms. We also identified Bromodomain PHD Finger Transcription Factor (BPTF), a key component of the NURF chromatin remodeling complex, as a potential target responsible for transcriptome changes related to human neuropsychiatric diseases, including ASD. We provide a practical and straightforward analytical workflow for utilizing both public data and in-house single-cell omics data from disease models. En ligne : https://doi.org/10.1002/aur.70156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Single-Cell Transcriptome Meta-Analysis Reveals Epigenomic and Chromatin Dysregulation in Developing Neurons Derived From Human ESCs With 1q21.1 CNVs [texte imprimé] / Kosuke TORIGATA, Auteur ; Jun NOMURA, Auteur ; Toru TAKUMI, Auteur . - p.e70156. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70156 Mots-clés : chromatin  copy number variation  epigenome  human ES cell  single-cell transcriptome Index. décimale : PER Périodiques Résumé : ABSTRACT Recent efforts to construct disease-specific multimodal omics databases at single-cell resolution, along with advances in reconstructive technologies such as brain organoids, have opened up opportunities to elucidate the molecular basis of complex human neuropsychiatric diseases. In this study, we performed a meta-analysis to characterize disease-associated regulatory modules by performing single-cell transcriptome analysis of developing neurons from reciprocal human ESC models of CNV in the distal 1q21.1 region. As a result, we observed significant directional enrichment of a series of genes in neuronal cells associated with autism spectrum disorder (ASD), bipolar disorder, and schizophrenia. Correlation analyses revealed that the disease-associated signature primarily targeted epigenetic regulatory mechanisms. We also identified Bromodomain PHD Finger Transcription Factor (BPTF), a key component of the NURF chromatin remodeling complex, as a potential target responsible for transcriptome changes related to human neuropsychiatric diseases, including ASD. We provide a practical and straightforward analytical workflow for utilizing both public data and in-house single-cell omics data from disease models. En ligne : https://doi.org/10.1002/aur.70156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Microstructural White Matter Alterations in Angelman Syndrome: A Fixel-Based Analysis / Lei WEI in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70160 Titre : Microstructural White Matter Alterations in Angelman Syndrome: A Fixel-Based Analysis Type de document : texte imprimé Auteurs : Lei WEI, Auteur ; Xiaonan DU, Auteur ; Zhongwei QIAO, Auteur ; Baofeng YANG, Auteur ; Shasha LONG, Auteur ; Yonghui JIANG, Auteur ; Yi WANG, Auteur ; He WANG, Auteur Article en page(s) : p.e70160 Langues : Anglais (eng) Mots-clés : Angelman syndrome  fixel-based analysis  magnetic resonance imaging  seizure Index. décimale : PER Périodiques Résumé : ABSTRACT Angelman syndrome (AS) is a neurodevelopmental disorder resulting from UBE3A gene mutations, characterized by intellectual disability, movement disorders, language difficulties, ataxia, microcephaly, and seizures. While previous studies have examined brain connectivity in AS, the specifics of white matter structural changes have remained unclear. In this study, we utilized advanced diffusion MRI techniques to investigate the microstructural abnormalities of white matter for AS patients. A total of 30 AS patients and 19 age- and sex-matched healthy controls were included in the study. We used metrics derived from both fixel-based analysis (FBA) and diffusion tensor imaging to compare the white matter microstructure differences between AS patients and healthy controls. The results indicate that patients with AS have white matter microstructural differences throughout the whole brain, particularly in the corticospinal tract, arcuate fasciculate, and corpus callosum. FBA-derived metrics demonstrated greater specificity and sensitivity than tensor-based measures. Subsequently, we extracted six fiber tracts with significant differences from the FBA analysis and conducted tract-based statistics, including parieto-occipital pontine, anterior commissure, arcuate fasciculate, corticospinal tract, splenium of corpus callosum, and isthmus of corpus callosum. In all six fiber tracts, we found that AS patients with a higher frequency of seizures exhibited more white matter alterations. Overall, this study provides new insights into the structural differences in AS and their association with clinical symptoms, highlighting the extensive white matter differences and their potential impact on patient outcomes. En ligne : https://doi.org/10.1002/aur.70160 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Microstructural White Matter Alterations in Angelman Syndrome: A Fixel-Based Analysis [texte imprimé] / Lei WEI, Auteur ; Xiaonan DU, Auteur ; Zhongwei QIAO, Auteur ; Baofeng YANG, Auteur ; Shasha LONG, Auteur ; Yonghui JIANG, Auteur ; Yi WANG, Auteur ; He WANG, Auteur . - p.e70160. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70160 Mots-clés : Angelman syndrome  fixel-based analysis  magnetic resonance imaging  seizure Index. décimale : PER Périodiques Résumé : ABSTRACT Angelman syndrome (AS) is a neurodevelopmental disorder resulting from UBE3A gene mutations, characterized by intellectual disability, movement disorders, language difficulties, ataxia, microcephaly, and seizures. While previous studies have examined brain connectivity in AS, the specifics of white matter structural changes have remained unclear. In this study, we utilized advanced diffusion MRI techniques to investigate the microstructural abnormalities of white matter for AS patients. A total of 30 AS patients and 19 age- and sex-matched healthy controls were included in the study. We used metrics derived from both fixel-based analysis (FBA) and diffusion tensor imaging to compare the white matter microstructure differences between AS patients and healthy controls. The results indicate that patients with AS have white matter microstructural differences throughout the whole brain, particularly in the corticospinal tract, arcuate fasciculate, and corpus callosum. FBA-derived metrics demonstrated greater specificity and sensitivity than tensor-based measures. Subsequently, we extracted six fiber tracts with significant differences from the FBA analysis and conducted tract-based statistics, including parieto-occipital pontine, anterior commissure, arcuate fasciculate, corticospinal tract, splenium of corpus callosum, and isthmus of corpus callosum. In all six fiber tracts, we found that AS patients with a higher frequency of seizures exhibited more white matter alterations. Overall, this study provides new insights into the structural differences in AS and their association with clinical symptoms, highlighting the extensive white matter differences and their potential impact on patient outcomes. En ligne : https://doi.org/10.1002/aur.70160 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Effects of Peer Relationships and Teacher–Student Relationships on Aggressive Behaviors in Chinese Children With Autism Spectrum Disorders Placed in Regular Classrooms and the Mediating Role of Perceived Discrimination / Shuman WU in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70165 Titre : Effects of Peer Relationships and Teacher–Student Relationships on Aggressive Behaviors in Chinese Children With Autism Spectrum Disorders Placed in Regular Classrooms and the Mediating Role of Perceived Discrimination Type de document : texte imprimé Auteurs : Shuman WU, Auteur ; Jiayue GONG, Auteur Article en page(s) : p.e70165 Langues : Anglais (eng) Mots-clés : aggressive behavior  autism spectrum disorder  peer relationship  perceived discrimination  placed in regular classrooms  teacher–student relationship Index. décimale : PER Périodiques Résumé : ABSTRACT This study investigates the associations of peer relationships and teacher?student relationships with aggressive behaviors in Chinese children with autism spectrum disorder (ASD) placed in regular classrooms, with a specific focus on the mediating role of perceived discrimination. Data are collected from multiple sources, involving 189 ASD children and their teachers across 22 regular primary schools in Guangzhou, Guangdong Province, China. Following behavioral experiments, questionnaire assessments, and data analysis using partial least squares structural equation modeling (PLS-SEM), this study reveals three key findings: (1) both peer relationships and teacher?student relationships negatively affect aggressive behaviors in children with ASD; (2) perceived discrimination positively influences such aggressive behaviors; and (3) both peer and teacher?student relationships indirectly influence aggressive behaviors through the mediation of perceived discrimination. These findings emphasize the need of enhancing on-campus social connections to reduce perceived discrimination among ASD children, thereby mitigating aggressive behaviors, and highlight the necessity of fostering a supportive integrated educational environment in regular classroom settings. En ligne : https://doi.org/10.1002/aur.70165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Effects of Peer Relationships and Teacher–Student Relationships on Aggressive Behaviors in Chinese Children With Autism Spectrum Disorders Placed in Regular Classrooms and the Mediating Role of Perceived Discrimination [texte imprimé] / Shuman WU, Auteur ; Jiayue GONG, Auteur . - p.e70165. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70165 Mots-clés : aggressive behavior  autism spectrum disorder  peer relationship  perceived discrimination  placed in regular classrooms  teacher–student relationship Index. décimale : PER Périodiques Résumé : ABSTRACT This study investigates the associations of peer relationships and teacher?student relationships with aggressive behaviors in Chinese children with autism spectrum disorder (ASD) placed in regular classrooms, with a specific focus on the mediating role of perceived discrimination. Data are collected from multiple sources, involving 189 ASD children and their teachers across 22 regular primary schools in Guangzhou, Guangdong Province, China. Following behavioral experiments, questionnaire assessments, and data analysis using partial least squares structural equation modeling (PLS-SEM), this study reveals three key findings: (1) both peer relationships and teacher?student relationships negatively affect aggressive behaviors in children with ASD; (2) perceived discrimination positively influences such aggressive behaviors; and (3) both peer and teacher?student relationships indirectly influence aggressive behaviors through the mediation of perceived discrimination. These findings emphasize the need of enhancing on-campus social connections to reduce perceived discrimination among ASD children, thereby mitigating aggressive behaviors, and highlight the necessity of fostering a supportive integrated educational environment in regular classroom settings. En ligne : https://doi.org/10.1002/aur.70165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Trends Over Time in the Prevalence of Autism by Adaptive and Intellectual Functioning Levels / Sarah M. FURNIER in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70167 Titre : Trends Over Time in the Prevalence of Autism by Adaptive and Intellectual Functioning Levels Type de document : texte imprimé Auteurs : Sarah M. FURNIER, Auteur ; Ronald GANGNON, Auteur ; Maureen S. DURKIN, Auteur Article en page(s) : p.e70167 Langues : Anglais (eng) Mots-clés : adaptive behavior  adaptive functioning  co-occurring conditions  intellectual disability  IQ  prevalence Index. décimale : PER Périodiques Résumé : ABSTRACT The autistic community is a large, growing, and heterogeneous population, and there is a need for improved methods to describe their diverse needs. Measures of adaptive functioning collected through public health surveillance may provide valuable information on functioning and support needs at a population level. We aimed to use adaptive behavior and cognitive scores abstracted from health and educational records to describe trends over time in the population prevalence of autism by adaptive level and co-occurrence of intellectual disability (ID). Using data from the Autism and Developmental Disabilities Monitoring Network, years 2000 to 2016, we estimated the prevalence of autism per 1000 8-year-old children by four levels of adaptive challenges (moderate to profound, mild, borderline, or none) and by co-occurrence of ID. The prevalence of autism with mild, borderline, or no significant adaptive challenges increased between 2000 and 2016, from 5.1 per 1000 (95% confidence interval [CI]: 4.6?5.5) to 17.6 (95% CI: 17.1?18.1) while the prevalence of autism with moderate to profound challenges decreased slightly, from 1.5 (95% CI: 1.2?1.7) to 1.2 (95% CI: 1.1?1.4). The prevalence increase was greater for autism without co-occurring ID than for autism with co-occurring ID. The increase in autism prevalence between 2000 and 2016 was confined to autism with milder phenotypes. This trend could indicate improved identification of milder forms of autism over time. It is possible that increased access to therapies that improve intellectual and adaptive functioning of children diagnosed with autism also contributed to the trends. En ligne : https://doi.org/10.1002/aur.70167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Trends Over Time in the Prevalence of Autism by Adaptive and Intellectual Functioning Levels [texte imprimé] / Sarah M. FURNIER, Auteur ; Ronald GANGNON, Auteur ; Maureen S. DURKIN, Auteur . - p.e70167. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70167 Mots-clés : adaptive behavior  adaptive functioning  co-occurring conditions  intellectual disability  IQ  prevalence Index. décimale : PER Périodiques Résumé : ABSTRACT The autistic community is a large, growing, and heterogeneous population, and there is a need for improved methods to describe their diverse needs. Measures of adaptive functioning collected through public health surveillance may provide valuable information on functioning and support needs at a population level. We aimed to use adaptive behavior and cognitive scores abstracted from health and educational records to describe trends over time in the population prevalence of autism by adaptive level and co-occurrence of intellectual disability (ID). Using data from the Autism and Developmental Disabilities Monitoring Network, years 2000 to 2016, we estimated the prevalence of autism per 1000 8-year-old children by four levels of adaptive challenges (moderate to profound, mild, borderline, or none) and by co-occurrence of ID. The prevalence of autism with mild, borderline, or no significant adaptive challenges increased between 2000 and 2016, from 5.1 per 1000 (95% confidence interval [CI]: 4.6?5.5) to 17.6 (95% CI: 17.1?18.1) while the prevalence of autism with moderate to profound challenges decreased slightly, from 1.5 (95% CI: 1.2?1.7) to 1.2 (95% CI: 1.1?1.4). The prevalence increase was greater for autism without co-occurring ID than for autism with co-occurring ID. The increase in autism prevalence between 2000 and 2016 was confined to autism with milder phenotypes. This trend could indicate improved identification of milder forms of autism over time. It is possible that increased access to therapies that improve intellectual and adaptive functioning of children diagnosed with autism also contributed to the trends. En ligne : https://doi.org/10.1002/aur.70167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Clinically Significant Outcomes of Early Intensive Behavioral Intervention for Children With Autism Spectrum Disorders: An Individual Participant Data Meta-Analysis / Sigmund ELDEVIK in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70169 Titre : Clinically Significant Outcomes of Early Intensive Behavioral Intervention for Children With Autism Spectrum Disorders: An Individual Participant Data Meta-Analysis Type de document : texte imprimé Auteurs : Sigmund ELDEVIK, Auteur ; Børge STRØMGREN, Auteur ; Svein EIKESETH, Auteur ; Anya FIELDS, Auteur ; C. Melanie GOETZ, Auteur ; Kristine Berg TITLESTAD, Auteur Article en page(s) : p.e70169 Langues : Anglais (eng) Mots-clés : early intensive behavioral intervention  EIBI  individual participant data  meta-analysis  outcome Index. décimale : PER Périodiques Résumé : ABSTRACT Early Intensive Behavioral Intervention (EIBI) is widely recommended for children with Autism Spectrum Disorder (ASD). However, the treatment intensity and effectiveness have been debated. We conducted a meta-analysis and examined individual participant data to evaluate the effectiveness and clinical significance of the outcomes on adaptive behavior, intellectual functioning, and autism severity. We included studies of children with ASD aged 2?6?years who received EIBI for at least 12?months. The final literature search was conducted on September 26, 2024. The GRADE tool was used to assess the risk of bias. Across the 17 identified studies, we obtained participant data from 15 studies: 341 children received EIBI and 280 were in comparison-groups. All studies had a serious risk of bias due to the lack of random assignment. Our meta-analysis yielded effect sizes of 0.66 for improvement in adaptive behavior, 0.87 for improvement in intellectual functioning and 1.36 for reductions in ASD severity. A significantly higher percentage of children in the EIBI-group met the criteria for statistically reliable change and scored in the non-clinical range post-intervention with a Number Needed to Treat between 4.1 and 6.9. We found that treatment intensity significantly contributed to changes across all outcome measures. Based on our analyses we propose benchmarks for evaluating interventions for children with ASD. Although EIBI demonstrates broad, substantial effects, some uncertainty remains due to the lack of random assignment in the reviewed studies. Nonetheless, EIBI should currently be considered as the preferred treatment for children with ASD. En ligne : https://doi.org/10.1002/aur.70169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Clinically Significant Outcomes of Early Intensive Behavioral Intervention for Children With Autism Spectrum Disorders: An Individual Participant Data Meta-Analysis [texte imprimé] / Sigmund ELDEVIK, Auteur ; Børge STRØMGREN, Auteur ; Svein EIKESETH, Auteur ; Anya FIELDS, Auteur ; C. Melanie GOETZ, Auteur ; Kristine Berg TITLESTAD, Auteur . - p.e70169. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70169 Mots-clés : early intensive behavioral intervention  EIBI  individual participant data  meta-analysis  outcome Index. décimale : PER Périodiques Résumé : ABSTRACT Early Intensive Behavioral Intervention (EIBI) is widely recommended for children with Autism Spectrum Disorder (ASD). However, the treatment intensity and effectiveness have been debated. We conducted a meta-analysis and examined individual participant data to evaluate the effectiveness and clinical significance of the outcomes on adaptive behavior, intellectual functioning, and autism severity. We included studies of children with ASD aged 2?6?years who received EIBI for at least 12?months. The final literature search was conducted on September 26, 2024. The GRADE tool was used to assess the risk of bias. Across the 17 identified studies, we obtained participant data from 15 studies: 341 children received EIBI and 280 were in comparison-groups. All studies had a serious risk of bias due to the lack of random assignment. Our meta-analysis yielded effect sizes of 0.66 for improvement in adaptive behavior, 0.87 for improvement in intellectual functioning and 1.36 for reductions in ASD severity. A significantly higher percentage of children in the EIBI-group met the criteria for statistically reliable change and scored in the non-clinical range post-intervention with a Number Needed to Treat between 4.1 and 6.9. We found that treatment intensity significantly contributed to changes across all outcome measures. Based on our analyses we propose benchmarks for evaluating interventions for children with ASD. Although EIBI demonstrates broad, substantial effects, some uncertainty remains due to the lack of random assignment in the reviewed studies. Nonetheless, EIBI should currently be considered as the preferred treatment for children with ASD. En ligne : https://doi.org/10.1002/aur.70169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578