Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life / A. ESTES in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.24 Titre : Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life Type de document : Texte imprimé et/ou numérique Auteurs : A. ESTES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; H. GU, Auteur ; T. ST JOHN, Auteur ; S. PATERSON, Auteur ; J. T. ELISON, Auteur ; Heather C. HAZLETT, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Robert T. SCHULTZ, Auteur ; P. KOSTOPOULOS, Auteur ; A. EVANS, Auteur ; G. DAWSON, Auteur ; J. ELIASON, Auteur ; S. ALVAREZ, Auteur ; J. PIVEN, Auteur Article en page(s) : p.24 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics of infants at high familial risk for ASD (HR), and infants at low risk (LR). METHODS: Participants included 210 HR and 98 LR infants across 4 sites with comparable behavioral data at age 6, 12, and 24 months assessed in the domains of cognitive development (Mullen Scales of Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), and early behavioral features of ASD (Autism Observation Scale for Infants). Participants evaluated according to the DSM-IV-TR criteria at 24 months and categorized as ASD-positive or ASD-negative were further stratified by empirically derived cutoff scores using the Autism Diagnostic Observation Schedule yielding four groups: HR-ASD-High, HR-ASD-Moderate (HR-ASD-Mod), HR-ASD-Negative (HR-Neg), and LR-ASD-Negative (LR-Neg). RESULTS: The four groups demonstrated different developmental trajectories that became increasingly distinct from 6 to 24 months across all domains. At 6 months, the HR-ASD-High group demonstrated less advanced Gross Motor and Visual Reception skills compared with the LR-Neg group. By 12 months, the HR-ASD-High group demonstrated increased behavioral features of ASD and decreased cognitive and adaptive functioning compared to the HR-Neg and LR-Neg groups. By 24 months, both the HR-ASD-High and HR-ASD-Moderate groups demonstrated differences from the LR- and HR-Neg groups in all domains. CONCLUSIONS: These findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants. Sensorimotor differences precede the unfolding of cognitive and adaptive deficits and behavioral features of autism across the 6- to 24-month interval. The less severely affected group demonstrates later symptom onset, in the second year of life, with initial differences in the social-communication domain. En ligne : http://dx.doi.org/10.1186/s11689-015-9117-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life [Texte imprimé et/ou numérique] / A. ESTES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; H. GU, Auteur ; T. ST JOHN, Auteur ; S. PATERSON, Auteur ; J. T. ELISON, Auteur ; Heather C. HAZLETT, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Robert T. SCHULTZ, Auteur ; P. KOSTOPOULOS, Auteur ; A. EVANS, Auteur ; G. DAWSON, Auteur ; J. ELIASON, Auteur ; S. ALVAREZ, Auteur ; J. PIVEN, Auteur . - p.24. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.24 Index. décimale : PER Périodiques Résumé : BACKGROUND: To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics of infants at high familial risk for ASD (HR), and infants at low risk (LR). METHODS: Participants included 210 HR and 98 LR infants across 4 sites with comparable behavioral data at age 6, 12, and 24 months assessed in the domains of cognitive development (Mullen Scales of Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), and early behavioral features of ASD (Autism Observation Scale for Infants). Participants evaluated according to the DSM-IV-TR criteria at 24 months and categorized as ASD-positive or ASD-negative were further stratified by empirically derived cutoff scores using the Autism Diagnostic Observation Schedule yielding four groups: HR-ASD-High, HR-ASD-Moderate (HR-ASD-Mod), HR-ASD-Negative (HR-Neg), and LR-ASD-Negative (LR-Neg). RESULTS: The four groups demonstrated different developmental trajectories that became increasingly distinct from 6 to 24 months across all domains. At 6 months, the HR-ASD-High group demonstrated less advanced Gross Motor and Visual Reception skills compared with the LR-Neg group. By 12 months, the HR-ASD-High group demonstrated increased behavioral features of ASD and decreased cognitive and adaptive functioning compared to the HR-Neg and LR-Neg groups. By 24 months, both the HR-ASD-High and HR-ASD-Moderate groups demonstrated differences from the LR- and HR-Neg groups in all domains. CONCLUSIONS: These findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants. Sensorimotor differences precede the unfolding of cognitive and adaptive deficits and behavioral features of autism across the 6- to 24-month interval. The less severely affected group demonstrates later symptom onset, in the second year of life, with initial differences in the social-communication domain. En ligne : http://dx.doi.org/10.1186/s11689-015-9117-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD / Catherine A. BURROWS in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1710-1723 Titre : Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD Type de document : Texte imprimé et/ou numérique Auteurs : Catherine A. BURROWS, Auteur ; James W. BODFISH, Auteur ; J. J. WOLFF, Auteur ; E. P. VOLLMAN, Auteur ; Melody R. ALTSCHULER, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; J. R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; J. T. ELISON, Auteur Article en page(s) : p.1710-1723 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child, Preschool  Family  Humans  Infant  Male  Phenotype  Risk  Siblings  attention  intense interests  problem behavior  restricted interests  toddlers Index. décimale : PER Périodiques Résumé : Intense interests are common in children with and without autism spectrum disorder (ASD), and little research has characterized aspects of interests that are unique to or shared among children with and without ASD. We aimed to characterize interests in a sample of infants at high-familial-risk (HR) and low-familial-risk (LR) for ASD using a novel interview. Participants included HR siblings who were diagnosed with ASD at 24?months (HR-ASD, n = 56), HR siblings who did not receive an ASD diagnosis at 24?months (HR-Neg, n = 187), and a LR comparison group (n = 109). We developed and collected data with the Intense Interests Inventory at 18- and 24-months of age, a semi-structured interview that measures intensity and peculiarity of interests in toddlers and preschool-aged children. Intensity of interests differed by familial risk at 24?months, with HR-ASD and HR-Neg groups demonstrating equivalent intensity of interests that were higher than the LR group. By contrast, peculiarity of interest differed by ASD diagnosis, with the HR-ASD group showing more peculiar interests than the HR-Neg and LR groups at 24?months. At 18?months the HR-ASD group had more peculiar interests than the LR group, though no differences emerged in intensity of interests. This measure may be useful in identifying clinically-relevant features of interests in young children with ASD. We also replicated previous findings of males showing more intense interests at 18?months in our non-ASD sample. These results reveal new information about the nature of interests and preoccupations in the early autism phenotype. LAY SUMMARY: Intense interests are common in young children with autism and their family members. Intense interests are also prevalent among typically-developing children, and especially boys. Here we catalog interests and features of these interests in a large sample of toddlers enriched for autism risk. Children who had family members with autism had more intense interests, and those who developed autism themselves had more unusual interests at 24?months. These results highlight the importance of different aspects of interest in autism. En ligne : http://dx.doi.org/10.1002/aur.2543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD [Texte imprimé et/ou numérique] / Catherine A. BURROWS, Auteur ; James W. BODFISH, Auteur ; J. J. WOLFF, Auteur ; E. P. VOLLMAN, Auteur ; Melody R. ALTSCHULER, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; J. R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; J. T. ELISON, Auteur . - p.1710-1723. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1710-1723 Mots-clés : Autism Spectrum Disorder  Child, Preschool  Family  Humans  Infant  Male  Phenotype  Risk  Siblings  attention  intense interests  problem behavior  restricted interests  toddlers Index. décimale : PER Périodiques Résumé : Intense interests are common in children with and without autism spectrum disorder (ASD), and little research has characterized aspects of interests that are unique to or shared among children with and without ASD. We aimed to characterize interests in a sample of infants at high-familial-risk (HR) and low-familial-risk (LR) for ASD using a novel interview. Participants included HR siblings who were diagnosed with ASD at 24?months (HR-ASD, n = 56), HR siblings who did not receive an ASD diagnosis at 24?months (HR-Neg, n = 187), and a LR comparison group (n = 109). We developed and collected data with the Intense Interests Inventory at 18- and 24-months of age, a semi-structured interview that measures intensity and peculiarity of interests in toddlers and preschool-aged children. Intensity of interests differed by familial risk at 24?months, with HR-ASD and HR-Neg groups demonstrating equivalent intensity of interests that were higher than the LR group. By contrast, peculiarity of interest differed by ASD diagnosis, with the HR-ASD group showing more peculiar interests than the HR-Neg and LR groups at 24?months. At 18?months the HR-ASD group had more peculiar interests than the LR group, though no differences emerged in intensity of interests. This measure may be useful in identifying clinically-relevant features of interests in young children with ASD. We also replicated previous findings of males showing more intense interests at 18?months in our non-ASD sample. These results reveal new information about the nature of interests and preoccupations in the early autism phenotype. LAY SUMMARY: Intense interests are common in young children with autism and their family members. Intense interests are also prevalent among typically-developing children, and especially boys. Here we catalog interests and features of these interests in a large sample of toddlers enriched for autism risk. Children who had family members with autism had more intense interests, and those who developed autism themselves had more unusual interests at 24?months. These results highlight the importance of different aspects of interest in autism. En ligne : http://dx.doi.org/10.1002/aur.2543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Diagnostic shifts in autism spectrum disorder can be linked to the fuzzy nature of the diagnostic boundary: a data-driven approach / B. TUNC in Journal of Child Psychology and Psychiatry, 62-10 (October 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1236-1245 Titre : Diagnostic shifts in autism spectrum disorder can be linked to the fuzzy nature of the diagnostic boundary: a data-driven approach Type de document : Texte imprimé et/ou numérique Auteurs : B. TUNC, Auteur ; J. PANDEY, Auteur ; T. ST JOHN, Auteur ; S. S. MEERA, Auteur ; J. E. MALDARELLI, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Heather C. HAZLETT, Auteur ; Stephen R. DAGER, Auteur ; Kelly N. BOTTERON, Auteur ; J. B. GIRAULT, Auteur ; R. C. MCKINSTRY, Auteur ; R. VERMA, Auteur ; J. T. ELISON, Auteur ; J. R. PRUETT, Auteur ; J. PIVEN, Auteur ; A. M. ESTES, Auteur ; Robert T. SCHULTZ, Auteur Article en page(s) : p.1236-1245 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Child, Preschool  Cohort Studies  Early Diagnosis  Humans  Phenotype  Siblings  Autism spectrum disorders  diagnosis  infancy  machine learning  stability  interest Index. décimale : PER Périodiques Résumé : BACKGROUND: Diagnostic shifts at early ages may provide invaluable insights into the nature of separation between autism spectrum disorder (ASD) and typical development. Recent conceptualizations of ASD suggest the condition is only fuzzily separated from non-ASD, with intermediate cases between the two. These intermediate cases may shift along a transition region over time, leading to apparent instability of diagnosis. METHODS: We used a cohort of children with high ASD risk, by virtue of having an older sibling with ASD, assessed at 24 months (N = 212) and 36 months (N = 191). We applied machine learning to empirically characterize the classification boundary between ASD and non-ASD, using variables quantifying developmental and adaptive skills. We computed the distance of children to the classification boundary. RESULTS: Children who switched diagnostic labels from 24 to 36 months, in both directions, (dynamic group) had intermediate phenotypic profiles. They were closer to the classification boundary compared to children who had stable diagnoses, both at 24 months (Cohen's d = .52) and at 36 months (d = .75). The magnitude of change in distance between the two time points was similar for the dynamic and stable groups (Cohen's d = .06), and diagnostic shifts were not associated with a large change. At the individual level, a few children in the dynamic group showed substantial change. CONCLUSIONS: Our results suggested that a diagnostic shift was largely due to a slight movement within a transition region between ASD and non-ASD. This fact highlights the need for more vigilant surveillance and intervention strategies. Young children with intermediate phenotypes may have an increased susceptibility to gain or lose their diagnosis at later ages, calling attention to the inherently dynamic nature of early ASD diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.13406 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Diagnostic shifts in autism spectrum disorder can be linked to the fuzzy nature of the diagnostic boundary: a data-driven approach [Texte imprimé et/ou numérique] / B. TUNC, Auteur ; J. PANDEY, Auteur ; T. ST JOHN, Auteur ; S. S. MEERA, Auteur ; J. E. MALDARELLI, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Heather C. HAZLETT, Auteur ; Stephen R. DAGER, Auteur ; Kelly N. BOTTERON, Auteur ; J. B. GIRAULT, Auteur ; R. C. MCKINSTRY, Auteur ; R. VERMA, Auteur ; J. T. ELISON, Auteur ; J. R. PRUETT, Auteur ; J. PIVEN, Auteur ; A. M. ESTES, Auteur ; Robert T. SCHULTZ, Auteur . - p.1236-1245. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1236-1245 Mots-clés : Autism Spectrum Disorder/diagnosis  Child, Preschool  Cohort Studies  Early Diagnosis  Humans  Phenotype  Siblings  Autism spectrum disorders  diagnosis  infancy  machine learning  stability  interest Index. décimale : PER Périodiques Résumé : BACKGROUND: Diagnostic shifts at early ages may provide invaluable insights into the nature of separation between autism spectrum disorder (ASD) and typical development. Recent conceptualizations of ASD suggest the condition is only fuzzily separated from non-ASD, with intermediate cases between the two. These intermediate cases may shift along a transition region over time, leading to apparent instability of diagnosis. METHODS: We used a cohort of children with high ASD risk, by virtue of having an older sibling with ASD, assessed at 24 months (N = 212) and 36 months (N = 191). We applied machine learning to empirically characterize the classification boundary between ASD and non-ASD, using variables quantifying developmental and adaptive skills. We computed the distance of children to the classification boundary. RESULTS: Children who switched diagnostic labels from 24 to 36 months, in both directions, (dynamic group) had intermediate phenotypic profiles. They were closer to the classification boundary compared to children who had stable diagnoses, both at 24 months (Cohen's d = .52) and at 36 months (d = .75). The magnitude of change in distance between the two time points was similar for the dynamic and stable groups (Cohen's d = .06), and diagnostic shifts were not associated with a large change. At the individual level, a few children in the dynamic group showed substantial change. CONCLUSIONS: Our results suggested that a diagnostic shift was largely due to a slight movement within a transition region between ASD and non-ASD. This fact highlights the need for more vigilant surveillance and intervention strategies. Young children with intermediate phenotypes may have an increased susceptibility to gain or lose their diagnosis at later ages, calling attention to the inherently dynamic nature of early ASD diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.13406 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research / K. LYALL in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2241-2253 Titre : Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research Type de document : Texte imprimé et/ou numérique Auteurs : K. LYALL, Auteur ; M. HOSSEINI, Auteur ; Christine LADD-ACOSTA, Auteur ; X. NING, Auteur ; D. CATELLIER, Auteur ; John N. CONSTANTINO, Auteur ; Lisa A. CROEN, Auteur ; A. J. KAAT, Auteur ; Kelly N. BOTTERON, Auteur ; Nicole R. BUSH, Auteur ; Stephen R. DAGER, Auteur ; C. S. DUARTE, Auteur ; M. D. FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; R. M. JOSEPH, Auteur ; Margaret R. KARAGAS, Auteur ; S. KORRICK, Auteur ; R. LANDA, Auteur ; D. MESSINGER, Auteur ; E. OKEN, Auteur ; S. OZONOFF, Auteur ; J. PIVEN, Auteur ; J. PANDEY, Auteur ; Sheela SATHYANARAYA, Auteur ; Robert T. SCHULTZ, Auteur ; T. ST JOHN, Auteur ; R. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; C. J. NEWSCHAFFER, Auteur Article en page(s) : p.2241-2253 Langues : Anglais (eng) Mots-clés : Adolescent  Area Under Curve  Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  Communication  Female  Humans  Male  Psychiatric Status Rating Scales/standards  Psychometrics  Reproducibility of Results  Social Behavior  Autism spectrum disorder  Quantitative traits  Social Responsiveness Scale  Social communication Index. décimale : PER Périodiques Résumé : Prior work proposed a shortened version of the Social Responsiveness Scale (SRS), a commonly used quantitative measure of social communication traits. We used data from 3031 participants (including 190 ASD cases) from the Environmental Influences on Child Health Outcomes (ECHO) Program to compare distributional properties and criterion validity of 16-item "short" to 65-item "full" SRS scores. Results demonstrated highly overlapping distributions of short and full scores. Both scores separated case from non-case individuals by approximately two standard deviations. ASD prediction was nearly identical for short and full scores (area under the curve values of 0.87, 0.86 respectively). Findings support comparability of shortened and full scores, suggesting opportunities to increase efficiency. Future work should confirm additional psychometric properties of short scores. En ligne : http://dx.doi.org/10.1007/s10803-020-04667-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research [Texte imprimé et/ou numérique] / K. LYALL, Auteur ; M. HOSSEINI, Auteur ; Christine LADD-ACOSTA, Auteur ; X. NING, Auteur ; D. CATELLIER, Auteur ; John N. CONSTANTINO, Auteur ; Lisa A. CROEN, Auteur ; A. J. KAAT, Auteur ; Kelly N. BOTTERON, Auteur ; Nicole R. BUSH, Auteur ; Stephen R. DAGER, Auteur ; C. S. DUARTE, Auteur ; M. D. FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; R. M. JOSEPH, Auteur ; Margaret R. KARAGAS, Auteur ; S. KORRICK, Auteur ; R. LANDA, Auteur ; D. MESSINGER, Auteur ; E. OKEN, Auteur ; S. OZONOFF, Auteur ; J. PIVEN, Auteur ; J. PANDEY, Auteur ; Sheela SATHYANARAYA, Auteur ; Robert T. SCHULTZ, Auteur ; T. ST JOHN, Auteur ; R. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; C. J. NEWSCHAFFER, Auteur . - p.2241-2253. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2241-2253 Mots-clés : Adolescent  Area Under Curve  Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  Communication  Female  Humans  Male  Psychiatric Status Rating Scales/standards  Psychometrics  Reproducibility of Results  Social Behavior  Autism spectrum disorder  Quantitative traits  Social Responsiveness Scale  Social communication Index. décimale : PER Périodiques Résumé : Prior work proposed a shortened version of the Social Responsiveness Scale (SRS), a commonly used quantitative measure of social communication traits. We used data from 3031 participants (including 190 ASD cases) from the Environmental Influences on Child Health Outcomes (ECHO) Program to compare distributional properties and criterion validity of 16-item "short" to 65-item "full" SRS scores. Results demonstrated highly overlapping distributions of short and full scores. Both scores separated case from non-case individuals by approximately two standard deviations. ASD prediction was nearly identical for short and full scores (area under the curve values of 0.87, 0.86 respectively). Findings support comparability of shortened and full scores, suggesting opportunities to increase efficiency. Future work should confirm additional psychometric properties of short scores. En ligne : http://dx.doi.org/10.1007/s10803-020-04667-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Infants later diagnosed with autism have lower canonical babbling ratios in the first year of life / L. D. YANKOWITZ in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 28 p. Titre : Infants later diagnosed with autism have lower canonical babbling ratios in the first year of life Type de document : Texte imprimé et/ou numérique Auteurs : L. D. YANKOWITZ, Auteur ; V. PETRULLA, Auteur ; S. PLATE, Auteur ; B. TUNC, Auteur ; W. GUTHRIE, Auteur ; S. S. MEERA, Auteur ; K. TENA, Auteur ; J. PANDEY, Auteur ; M. R. SWANSON, Auteur ; J. R. Jr PRUETT, Auteur ; M. COLA, Auteur ; A. RUSSELL, Auteur ; N. MARRUS, Auteur ; Heather C. HAZLETT, Auteur ; K. BOTTERON, Auteur ; J. N. CONSTANTINO, Auteur ; Stephen R. DAGER, Auteur ; A. ESTES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; Robert T. SCHULTZ, Auteur ; Julia PARISH-MORRIS, Auteur Article en page(s) : 28 p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Humans  Infant  Language Development Disorders/diagnosis  Longitudinal Studies  Reproducibility of Results Index. décimale : PER Périodiques Résumé : BACKGROUND: Canonical babbling-producing syllables with a mature consonant, full vowel, and smooth transition-is an important developmental milestone that typically occurs in the first year of life. Some studies indicate delayed or reduced canonical babbling in infants at high familial likelihood for autism spectrum disorder (ASD) or who later receive an ASD diagnosis, but evidence is mixed. More refined characterization of babbling in the first year of life in infants with high likelihood for ASD is needed. METHODS: Vocalizations produced at 6 and 12 months by infants (n=267) taking part in a longitudinal study were coded for canonical and non-canonical syllables. Infants were categorized as low familial likelihood (LL), high familial likelihood diagnosed with ASD at 24 months (HL-ASD) or not diagnosed (HL-Neg). Language delay was assessed based on 24-month expressive and receptive language scores. Canonical babble ratio (CBR) was calculated by dividing the number of canonical syllables by the number of total syllables. Generalized linear (mixed) models were used to assess the relationship between group membership and CBR, controlling for site, sex, and maternal education. Logistic regression was used to assess whether canonical babbling ratios at 6 and 12 months predict 24-month diagnostic outcome. RESULTS: No diagnostic group differences in CBR were detected at 6 months, but HL-ASD infants produced significantly lower CBR than both the HL-Neg and LL groups at 12 months. HL-Neg infants with language delay also showed reduced CBR at 12 months. Neither 6- nor 12-month CBR was significant predictors of 24-month diagnostic outcome (ASD versus no ASD) in logistic regression. LIMITATIONS: Small numbers of vocalizations produced by infants at 6 months may limit the reliability of CBR estimates. It is not known if results generalize to infants who are not at high familial likelihood, or infants from more diverse racial and socioeconomic backgrounds. CONCLUSIONS: Lower canonical babbling ratios are apparent by the end of the first year of life in ASD regardless of later language delay, but are also observed for infants with later language delay without ASD. Canonical babbling may lack specificity as an early marker when used on its own. En ligne : http://dx.doi.org/10.1186/s13229-022-00503-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Infants later diagnosed with autism have lower canonical babbling ratios in the first year of life [Texte imprimé et/ou numérique] / L. D. YANKOWITZ, Auteur ; V. PETRULLA, Auteur ; S. PLATE, Auteur ; B. TUNC, Auteur ; W. GUTHRIE, Auteur ; S. S. MEERA, Auteur ; K. TENA, Auteur ; J. PANDEY, Auteur ; M. R. SWANSON, Auteur ; J. R. Jr PRUETT, Auteur ; M. COLA, Auteur ; A. RUSSELL, Auteur ; N. MARRUS, Auteur ; Heather C. HAZLETT, Auteur ; K. BOTTERON, Auteur ; J. N. CONSTANTINO, Auteur ; Stephen R. DAGER, Auteur ; A. ESTES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; Robert T. SCHULTZ, Auteur ; Julia PARISH-MORRIS, Auteur . - 28 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 28 p. Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Humans  Infant  Language Development Disorders/diagnosis  Longitudinal Studies  Reproducibility of Results Index. décimale : PER Périodiques Résumé : BACKGROUND: Canonical babbling-producing syllables with a mature consonant, full vowel, and smooth transition-is an important developmental milestone that typically occurs in the first year of life. Some studies indicate delayed or reduced canonical babbling in infants at high familial likelihood for autism spectrum disorder (ASD) or who later receive an ASD diagnosis, but evidence is mixed. More refined characterization of babbling in the first year of life in infants with high likelihood for ASD is needed. METHODS: Vocalizations produced at 6 and 12 months by infants (n=267) taking part in a longitudinal study were coded for canonical and non-canonical syllables. Infants were categorized as low familial likelihood (LL), high familial likelihood diagnosed with ASD at 24 months (HL-ASD) or not diagnosed (HL-Neg). Language delay was assessed based on 24-month expressive and receptive language scores. Canonical babble ratio (CBR) was calculated by dividing the number of canonical syllables by the number of total syllables. Generalized linear (mixed) models were used to assess the relationship between group membership and CBR, controlling for site, sex, and maternal education. Logistic regression was used to assess whether canonical babbling ratios at 6 and 12 months predict 24-month diagnostic outcome. RESULTS: No diagnostic group differences in CBR were detected at 6 months, but HL-ASD infants produced significantly lower CBR than both the HL-Neg and LL groups at 12 months. HL-Neg infants with language delay also showed reduced CBR at 12 months. Neither 6- nor 12-month CBR was significant predictors of 24-month diagnostic outcome (ASD versus no ASD) in logistic regression. LIMITATIONS: Small numbers of vocalizations produced by infants at 6 months may limit the reliability of CBR estimates. It is not known if results generalize to infants who are not at high familial likelihood, or infants from more diverse racial and socioeconomic backgrounds. CONCLUSIONS: Lower canonical babbling ratios are apparent by the end of the first year of life in ASD regardless of later language delay, but are also observed for infants with later language delay without ASD. Canonical babbling may lack specificity as an early marker when used on its own. En ligne : http://dx.doi.org/10.1186/s13229-022-00503-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Language delay aggregates in toddler siblings of children with autism spectrum disorder / N. MARRUS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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Longitudinal patterns of repetitive behavior in toddlers with autism / Jason J. WOLFF in Journal of Child Psychology and Psychiatry, 55-8 (August 2014)  

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A longitudinal study of parent-reported sensory responsiveness in toddlers at-risk for autism / J. J. WOLFF in Journal of Child Psychology and Psychiatry, 60-3 (March 2019)  

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Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism / J. J. WOLFF in Molecular Autism, 8 (2017)  

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Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder / A. ESTES in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

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Relations of Restricted and Repetitive Behaviors to Social Skills in Toddlers with Autism / Pang CHAXIONG in Journal of Autism and Developmental Disorders, 52-4 (April 2022)  

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Repetitive and self-injurious behaviors: associations with caudate volume in autism and fragile X syndrome / J. J. WOLFF in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

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A Retrospective Video Analysis of Canonical Babbling and Volubility in Infants with Fragile X Syndrome at 9–12 Months of Age / Katie BELARDI in Journal of Autism and Developmental Disorders, 47-4 (April 2017)  

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Sensory Profiles in Relation to Later Adaptive Functioning Among Toddlers at High-Familial Likelihood for Autism / Emma WORTHLEY in Journal of Autism and Developmental Disorders, 54-6 (June 2024)  

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Social and non-social sensory responsivity in toddlers at high-risk for autism spectrum disorder / J. GUNDERSON in Autism Research, 14-10 (October 2021)  

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