Co-occurring Down Syndrome and Autism Spectrum Disorder: Cognitive, Adaptive, and Behavioral Characteristics / K. R. BRADBURY in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1235-1246 Titre : Co-occurring Down Syndrome and Autism Spectrum Disorder: Cognitive, Adaptive, and Behavioral Characteristics Type de document : Texte imprimé et/ou numérique Auteurs : K. R. BRADBURY, Auteur ; Emily I. ANDERBERG, Auteur ; L. HUANG-STORMS, Auteur ; I. VASILE, Auteur ; R. K. GREENE, Auteur ; S. W. DUVALL, Auteur Article en page(s) : p.1235-1246 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/epidemiology/psychology  Child  Cognition  Cognitive Dysfunction  Down Syndrome/complications/epidemiology/psychology  Humans  Adaptive functioning  Autism spectrum disorder  Cognitive functioning  Down syndrome  Dual diagnosis  Emotional and behavioral functioning Index. décimale : PER Périodiques Résumé : The current study explores functioning in individuals with co-occurring Autism Spectrum Disorder and Down Syndrome (ASD+DS; n?=?23), individuals with ASD and cognitive impairment (ASD+ID; n?=?99) and individuals with idiopathic ID (n?=?38). ANCOVA results revealed that individuals with ASD+DS showed strengths in behavioral functioning compared to individuals with ID and more similar behavioral functioning to those with ASD+ID (?(2)?=?0.12), with the exception of disruptive behaviors. Cognitive functioning (?(c)?=?0.41) and ASD symptomatology (?(2)?=?0.11) were more comparable for children with ASD+DS and ASD?+?ID than for individuals with ID. Individuals with ASD+DS had the lowest overall adaptive skills (?(2)?=?0.11). Findings highlight similarities between ASD+DS and ASD+ID groups, emphasizing the importance of ASD identification within the DS population to provide access to specific interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05016-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Co-occurring Down Syndrome and Autism Spectrum Disorder: Cognitive, Adaptive, and Behavioral Characteristics [Texte imprimé et/ou numérique] / K. R. BRADBURY, Auteur ; Emily I. ANDERBERG, Auteur ; L. HUANG-STORMS, Auteur ; I. VASILE, Auteur ; R. K. GREENE, Auteur ; S. W. DUVALL, Auteur . - p.1235-1246. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1235-1246 Mots-clés : Autism Spectrum Disorder/complications/epidemiology/psychology  Child  Cognition  Cognitive Dysfunction  Down Syndrome/complications/epidemiology/psychology  Humans  Adaptive functioning  Autism spectrum disorder  Cognitive functioning  Down syndrome  Dual diagnosis  Emotional and behavioral functioning Index. décimale : PER Périodiques Résumé : The current study explores functioning in individuals with co-occurring Autism Spectrum Disorder and Down Syndrome (ASD+DS; n?=?23), individuals with ASD and cognitive impairment (ASD+ID; n?=?99) and individuals with idiopathic ID (n?=?38). ANCOVA results revealed that individuals with ASD+DS showed strengths in behavioral functioning compared to individuals with ID and more similar behavioral functioning to those with ASD+ID (?(2)?=?0.12), with the exception of disruptive behaviors. Cognitive functioning (?(c)?=?0.41) and ASD symptomatology (?(2)?=?0.11) were more comparable for children with ASD+DS and ASD?+?ID than for individuals with ID. Individuals with ASD+DS had the lowest overall adaptive skills (?(2)?=?0.11). Findings highlight similarities between ASD+DS and ASD+ID groups, emphasizing the importance of ASD identification within the DS population to provide access to specific interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05016-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Functional MRI connectivity of children with autism and low verbal and cognitive performance / T. P. GABRIELSEN in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 67 p. Titre : Functional MRI connectivity of children with autism and low verbal and cognitive performance Type de document : Texte imprimé et/ou numérique Auteurs : T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Functional MRI connectivity of children with autism and low verbal and cognitive performance [Texte imprimé et/ou numérique] / T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 67 p. Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Predicting Parent Reactions at Diagnostic Disclosure Sessions for Autism / Emily I. ANDERBERG in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3533-3546 Titre : Predicting Parent Reactions at Diagnostic Disclosure Sessions for Autism Type de document : Texte imprimé et/ou numérique Auteurs : Emily I. ANDERBERG, Auteur ; M. SOUTH, Auteur Article en page(s) : p.3533-3546 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Disclosure  Humans  Parents  Surveys and Questionnaires  Assessment  Autism  Diagnostic disclosure  Diagnostic evaluation  Diagnostic feedback Index. décimale : PER Périodiques Résumé : Receiving a diagnosis of autism for their child can be a pivotal moment for parents, yet there is little research about how providers can predict parent reactions and adjust their feedback. We investigated factors related to parent reactions during the disclosure session using interviews with providers (n?=?6), a parent focus group (n?=?10), and a mixed-methods survey of parents (n?=?189) of recently diagnosed children. Parents' prior knowledge of autism and anxiety about diagnosis predicted emotional reactions and readiness for next steps. Families anxious about receiving a diagnosis are most in need of information but may leave the session feeling lost and unprepared. Providers can promote positive emotional reactions for parents and prevent confusion by increasing their own positivity, warmth, respect, clarity, and confidence. En ligne : http://dx.doi.org/10.1007/s10803-020-04817-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Predicting Parent Reactions at Diagnostic Disclosure Sessions for Autism [Texte imprimé et/ou numérique] / Emily I. ANDERBERG, Auteur ; M. SOUTH, Auteur . - p.3533-3546. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3533-3546 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Disclosure  Humans  Parents  Surveys and Questionnaires  Assessment  Autism  Diagnostic disclosure  Diagnostic evaluation  Diagnostic feedback Index. décimale : PER Périodiques Résumé : Receiving a diagnosis of autism for their child can be a pivotal moment for parents, yet there is little research about how providers can predict parent reactions and adjust their feedback. We investigated factors related to parent reactions during the disclosure session using interviews with providers (n?=?6), a parent focus group (n?=?10), and a mixed-methods survey of parents (n?=?189) of recently diagnosed children. Parents' prior knowledge of autism and anxiety about diagnosis predicted emotional reactions and readiness for next steps. Families anxious about receiving a diagnosis are most in need of information but may leave the session feeling lost and unprepared. Providers can promote positive emotional reactions for parents and prevent confusion by increasing their own positivity, warmth, respect, clarity, and confidence. En ligne : http://dx.doi.org/10.1007/s10803-020-04817-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder / Rebecca A. LUNDWALL in Research in Autism Spectrum Disorders, 34 (February 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Titre : Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder [Texte imprimé et/ou numérique] / Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur . - p.44-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials / Lawrence SCAHILL in Autism, 20-2 (February 2016)  

Public ISBD [article]  inAutism > 20-2 (February 2016) . - p.145-152 Titre : Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Denis G SUKHODOLSKY, Auteur ; Emily I. ANDERBERG, Auteur ; Anastasia DIMITROPOULOS, Auteur ; James DZIURA, Auteur ; Michael G. AMAN, Auteur ; James MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Victoria HALLETT, Auteur ; Karol KATZ, Auteur ; Benedetto VITIELLO, Auteur ; Christopher MCDOUGLE, Auteur Article en page(s) : p.145-152 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  clinical trials  outcome measurement  repetitive behavior  risperidone Index. décimale : PER Périodiques Résumé : Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4–17?years). At the medication-free baseline, the internal consistency on the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach’s alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74–0.88). There were no differences between active treatment groups. These results indicate that the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test–retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment. En ligne : http://dx.doi.org/10.1177/1362361315574889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Denis G SUKHODOLSKY, Auteur ; Emily I. ANDERBERG, Auteur ; Anastasia DIMITROPOULOS, Auteur ; James DZIURA, Auteur ; Michael G. AMAN, Auteur ; James MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Victoria HALLETT, Auteur ; Karol KATZ, Auteur ; Benedetto VITIELLO, Auteur ; Christopher MCDOUGLE, Auteur . - p.145-152. Langues : Anglais (eng) in Autism > 20-2 (February 2016) . - p.145-152 Mots-clés : autism spectrum disorder  clinical trials  outcome measurement  repetitive behavior  risperidone Index. décimale : PER Périodiques Résumé : Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4–17?years). At the medication-free baseline, the internal consistency on the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach’s alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74–0.88). There were no differences between active treatment groups. These results indicate that the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test–retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment. En ligne : http://dx.doi.org/10.1177/1362361315574889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Sticking with it: Psychotherapy outcomes for adults with autism spectrum disorder in a university counseling center setting / Emily I. ANDERBERG in Autism Research, 10-12 (December 2017)  

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