Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits / Jannath BEGUM-ALI in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1057-1067 Titre : Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits Type de document : texte imprimé Auteurs : Jannath BEGUM-ALI, Auteur ; Amy GOODWIN, Auteur ; Luke MASON, Auteur ; Greg PASCO, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur Article en page(s) : p.1057-1067 Langues : Anglais (eng) Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder  Child  Electroencephalography  Female  Humans  Infant  Male  Prospective Studies  Theta Rhythm  Attention deficit hyperactivity disorder  autism spectrum disorder  infancy  theta-beta ratio Index. décimale : PER Périodiques Résumé : BACKGROUND: Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prospective studies of infants with an elevated likelihood of developing ADHD. METHODS: We used a prospective design to examine an oscillatory electroencephalography profile that has been widely studied in both children and adults with ADHD - the balance between lower and higher frequencies operationalised as the theta-beta ratio (TBR). In the present study, we examined TBR in 136 10-month-old infants (72 male and 64 female) with/without an elevated likelihood of developing ADHD and/or a comparison disorder (Autism Spectrum Disorder; ASD). RESULTS: Infants with a first-degree relative with ADHD demonstrated lower TBR than infants without a first-degree relative with ADHD. Further, lower TBR at 10months was positively associated with temperament dimensions conceptually related to ADHD at 2years. TBR was not altered in infants with a family history of ASD. CONCLUSIONS: This is the first demonstration that alterations in TBR are present prior to behavioural symptoms of ADHD. However, these alterations manifest differently than those sometimes observed in older children with an ADHD diagnosis. Importantly, altered TBR was not seen in infants at elevated likelihood of developing ASD, suggesting a degree of specificity to ADHD. Taken together, these findings demonstrate that there are brain changes associated with a family history of ADHD observable in the first year of life. En ligne : http://dx.doi.org/10.1111/jcpp.13563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits [texte imprimé] / Jannath BEGUM-ALI, Auteur ; Amy GOODWIN, Auteur ; Luke MASON, Auteur ; Greg PASCO, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur . - p.1057-1067. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1057-1067 Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder  Child  Electroencephalography  Female  Humans  Infant  Male  Prospective Studies  Theta Rhythm  Attention deficit hyperactivity disorder  autism spectrum disorder  infancy  theta-beta ratio Index. décimale : PER Périodiques Résumé : BACKGROUND: Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prospective studies of infants with an elevated likelihood of developing ADHD. METHODS: We used a prospective design to examine an oscillatory electroencephalography profile that has been widely studied in both children and adults with ADHD - the balance between lower and higher frequencies operationalised as the theta-beta ratio (TBR). In the present study, we examined TBR in 136 10-month-old infants (72 male and 64 female) with/without an elevated likelihood of developing ADHD and/or a comparison disorder (Autism Spectrum Disorder; ASD). RESULTS: Infants with a first-degree relative with ADHD demonstrated lower TBR than infants without a first-degree relative with ADHD. Further, lower TBR at 10months was positively associated with temperament dimensions conceptually related to ADHD at 2years. TBR was not altered in infants with a family history of ASD. CONCLUSIONS: This is the first demonstration that alterations in TBR are present prior to behavioural symptoms of ADHD. However, these alterations manifest differently than those sometimes observed in older children with an ADHD diagnosis. Importantly, altered TBR was not seen in infants at elevated likelihood of developing ASD, suggesting a degree of specificity to ADHD. Taken together, these findings demonstrate that there are brain changes associated with a family history of ADHD observable in the first year of life. En ligne : http://dx.doi.org/10.1111/jcpp.13563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Attention control in autism: Eye-tracking findings from pre-school children in a low- and middle-income country setting / Luke MASON ; Rashi ARORA ; Supriya BHAVNANI ; Jayashree DASGUPTA ; Sheffali GULATI ; Teodora GLIGA ; Mark H. JOHNSON in Autism, 28-1 (January 2024)  

Public ISBD [article]  inAutism > 28-1 (January 2024) . - p.43?57 Titre : Attention control in autism: Eye-tracking findings from pre-school children in a low- and middle-income country setting Type de document : texte imprimé Auteurs : Luke MASON, Auteur ; Rashi ARORA, Auteur ; Supriya BHAVNANI, Auteur ; Jayashree DASGUPTA, Auteur ; Sheffali GULATI, Auteur ; Teodora GLIGA, Auteur ; Mark H. JOHNSON, Auteur Article en page(s) : p.43?57 Mots-clés : autism spectrum disorders  cognition (attention  learning  memory)  development  pre-school children Index. décimale : PER Périodiques Résumé : Alterations in the development of attention control and learning have been associated with autism and can be measured using the ?antisaccade task?, which assesses a child?s ability to make an oculomotor response away from a distracting stimulus, and learn to instead anticipate a later reward. We aimed to assess these cognitive processes using portable eye-tracking in an understudied population of pre-school children with and without a diagnosis of autism spectrum disorder in community settings in New Delhi, India. The eye-tracking antisaccade task was presented to children in three groups (n 104) (children with a clinical diagnosis of autism spectrum disorder or intellectual disability and children meeting developmental milestones). In accordance with findings from high-income, laboratory-based environments, children learnt to anticipate looks towards a reward, as well as inhibit eye-movements towards a distractor stimulus. We also provide novel evidence that while differences in inhibition responses might be applicable to multiple developmental conditions, a reduced learning to anticipate looks towards a target in this age group may be specific to autism. This eye-tracking task may, therefore, have the potential to identify and assess autism specific traits across development, and be used in longitudinal research studies such as investigating response to intervention in low-resource settings. Lay abstract The development of cognitive processes, such as attention control and learning, has been suggested to be altered in children with a diagnosis of autism spectrum disorder. However, nearly all of our understanding of the development of these cognitive processes comes from studies with school-aged or older children in high-income countries, and from research conducted in a controlled laboratory environment, thereby restricting the potential generalisability of results and away from the majority of the world?s population. We need to expand our research to investigate abilities beyond these limited settings. We address shortcomings in the literature by (1) studying attention control and learning in an understudied population of children in a low- and middle-income country setting in India, (2) focusing research on a critical younger age group of children and (3) using portable eye-tracking technology that can be taken into communities and healthcare settings to increase the accessibility of research in hard-to-reach populations. Our results provide novel evidence on differences in attention control and learning responses in groups of children with and without a diagnosis of autism spectrum disorder. We show that learning responses in children that we assessed through a portable eye-tracking task, called the ?antisaccade task?, may be specific to autism. This suggests that the methods we use may have the potential to identify and assess autism-specific traits across development, and be used in research in low-resource settings. En ligne : https://dx.doi.org/10.1177/13623613221149541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Attention control in autism: Eye-tracking findings from pre-school children in a low- and middle-income country setting [texte imprimé] / Luke MASON, Auteur ; Rashi ARORA, Auteur ; Supriya BHAVNANI, Auteur ; Jayashree DASGUPTA, Auteur ; Sheffali GULATI, Auteur ; Teodora GLIGA, Auteur ; Mark H. JOHNSON, Auteur . - p.43?57. in Autism > 28-1 (January 2024) . - p.43?57 Mots-clés : autism spectrum disorders  cognition (attention  learning  memory)  development  pre-school children Index. décimale : PER Périodiques Résumé : Alterations in the development of attention control and learning have been associated with autism and can be measured using the ?antisaccade task?, which assesses a child?s ability to make an oculomotor response away from a distracting stimulus, and learn to instead anticipate a later reward. We aimed to assess these cognitive processes using portable eye-tracking in an understudied population of pre-school children with and without a diagnosis of autism spectrum disorder in community settings in New Delhi, India. The eye-tracking antisaccade task was presented to children in three groups (n 104) (children with a clinical diagnosis of autism spectrum disorder or intellectual disability and children meeting developmental milestones). In accordance with findings from high-income, laboratory-based environments, children learnt to anticipate looks towards a reward, as well as inhibit eye-movements towards a distractor stimulus. We also provide novel evidence that while differences in inhibition responses might be applicable to multiple developmental conditions, a reduced learning to anticipate looks towards a target in this age group may be specific to autism. This eye-tracking task may, therefore, have the potential to identify and assess autism specific traits across development, and be used in longitudinal research studies such as investigating response to intervention in low-resource settings. Lay abstract The development of cognitive processes, such as attention control and learning, has been suggested to be altered in children with a diagnosis of autism spectrum disorder. However, nearly all of our understanding of the development of these cognitive processes comes from studies with school-aged or older children in high-income countries, and from research conducted in a controlled laboratory environment, thereby restricting the potential generalisability of results and away from the majority of the world?s population. We need to expand our research to investigate abilities beyond these limited settings. We address shortcomings in the literature by (1) studying attention control and learning in an understudied population of children in a low- and middle-income country setting in India, (2) focusing research on a critical younger age group of children and (3) using portable eye-tracking technology that can be taken into communities and healthcare settings to increase the accessibility of research in hard-to-reach populations. Our results provide novel evidence on differences in attention control and learning responses in groups of children with and without a diagnosis of autism spectrum disorder. We show that learning responses in children that we assessed through a portable eye-tracking task, called the ?antisaccade task?, may be specific to autism. This suggests that the methods we use may have the potential to identify and assess autism-specific traits across development, and be used in research in low-resource settings. En ligne : https://dx.doi.org/10.1177/13623613221149541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Autistic Traits Mediate Reductions in Social Attention in Adults with Anorexia Nervosa / Jess KERR-GAFFNEY in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2077-2090 Titre : Autistic Traits Mediate Reductions in Social Attention in Adults with Anorexia Nervosa Type de document : texte imprimé Auteurs : Jess KERR-GAFFNEY, Auteur ; Luke MASON, Auteur ; Emily JONES, Auteur ; Hannah HAYWARD, Auteur ; Amy HARRISON, Auteur ; Dennis MURPHY, Auteur ; Kate TCHANTURIA, Auteur Article en page(s) : p.2077-2090 Langues : Anglais (eng) Mots-clés : Adult  Affective Symptoms/psychology  Anorexia Nervosa/psychology  Anxiety/psychology  Attention  Autistic Disorder/psychology  Depression/psychology  Emotions  Eye Movements  Facial Recognition  Female  Humans  Male  Self Report  Time Factors  Young Adult  Anorexia nervosa  Autism spectrum disorder  Comorbidity  Eye-tracking  Social attention Index. décimale : PER Périodiques Résumé : Anorexia nervosa (AN) is associated with difficulties in social and emotional functioning. A significant proportion of individuals with AN show autistic traits, which may influence social attention. This study examined attention to faces and facial features in AN, recovered AN (REC), and healthy controls, as well as relationships with comorbid psychopathology. One hundred and forty-eight participants' eye movements were tracked while watching a naturalistic social scene. Anxiety, depression, alexithymia, and autistic traits were assessed via self-report questionnaires. Participants with AN spent significantly less time looking at faces compared to REC and controls; patterns of attention to individual facial features did not differ across groups. Autistic traits mediated the relationship between group and time spent looking at faces. En ligne : http://dx.doi.org/10.1007/s10803-020-04686-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Autistic Traits Mediate Reductions in Social Attention in Adults with Anorexia Nervosa [texte imprimé] / Jess KERR-GAFFNEY, Auteur ; Luke MASON, Auteur ; Emily JONES, Auteur ; Hannah HAYWARD, Auteur ; Amy HARRISON, Auteur ; Dennis MURPHY, Auteur ; Kate TCHANTURIA, Auteur . - p.2077-2090. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2077-2090 Mots-clés : Adult  Affective Symptoms/psychology  Anorexia Nervosa/psychology  Anxiety/psychology  Attention  Autistic Disorder/psychology  Depression/psychology  Emotions  Eye Movements  Facial Recognition  Female  Humans  Male  Self Report  Time Factors  Young Adult  Anorexia nervosa  Autism spectrum disorder  Comorbidity  Eye-tracking  Social attention Index. décimale : PER Périodiques Résumé : Anorexia nervosa (AN) is associated with difficulties in social and emotional functioning. A significant proportion of individuals with AN show autistic traits, which may influence social attention. This study examined attention to faces and facial features in AN, recovered AN (REC), and healthy controls, as well as relationships with comorbid psychopathology. One hundred and forty-eight participants' eye movements were tracked while watching a naturalistic social scene. Anxiety, depression, alexithymia, and autistic traits were assessed via self-report questionnaires. Participants with AN spent significantly less time looking at faces compared to REC and controls; patterns of attention to individual facial features did not differ across groups. Autistic traits mediated the relationship between group and time spent looking at faces. En ligne : http://dx.doi.org/10.1007/s10803-020-04686-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder / Elena Serena PICCARDI in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder Type de document : texte imprimé Auteurs : Elena Serena PICCARDI, Auteur ; Jannath BEGUM ALI, Auteur ; Emily J.H. JONES, Auteur ; Luke MASON, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Teodora GLIGA, Auteur ; BASIS/STAARS TEAM, Auteur Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Humans  Infant  Perception  Phenotype  Protective Factors  Alpha amplitude desynchronization  Attention deficit hyperactivity disorder  Autism spectrum disorder  Eeg  Infant sibling design  Repetition suppression  Tactile sensory processing  Tactile sensory seeking Index. décimale : PER Périodiques Résumé : BACKGROUNDS: Atypicalities in tactile processing are reported in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) but it remains unknown if they precede and associate with the traits of these disorders emerging in childhood. We investigated behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of ASD and/or ADHD compared to infants at typical likelihood of the disorders. Further, we assessed the specificity of associations between infant markers and later ASD or ADHD traits. METHODS: Ninety-one 10-month-old infants participated in the study (n = 44 infants at elevated likelihood of ASD; n = 20 infants at elevated likelihood of ADHD; n = 9 infants at elevated likelihood of ASD and ADHD; n = 18 infants at typical likelihood of the disorders). Behavioural and EEG responses to pairs of tactile stimuli were experimentally recorded and concurrent parental reports of tactile responsiveness were collected. ASD and ADHD traits were measured at 24 months through standardized assessment (ADOS-2) and parental report (ECBQ), respectively. RESULTS: There was no effect of infants' likelihood status on behavioural markers of tactile sensory processing. Conversely, increased ASD likelihood associated with reduced neural repetition suppression to tactile input. Reduced neural repetition suppression at 10 months significantly predicted ASD (but not ADHD) traits at 24 months across the entire sample. Elevated tactile sensory seeking at 10 months moderated the relationship between early reduced neural repetition suppression and later ASD traits. CONCLUSIONS: Reduced tactile neural repetition suppression is an early marker of later ASD traits in infants at elevated likelihood of ASD or ADHD, suggesting that a common pathway to later ASD traits exists despite different familial backgrounds. Elevated tactile sensory seeking may act as a protective factor, mitigating the relationship between early tactile neural repetition suppression and later ASD traits. En ligne : https://dx.doi.org/10.1186/s11689-020-09334-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder [texte imprimé] / Elena Serena PICCARDI, Auteur ; Jannath BEGUM ALI, Auteur ; Emily J.H. JONES, Auteur ; Luke MASON, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Teodora GLIGA, Auteur ; BASIS/STAARS TEAM, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Humans  Infant  Perception  Phenotype  Protective Factors  Alpha amplitude desynchronization  Attention deficit hyperactivity disorder  Autism spectrum disorder  Eeg  Infant sibling design  Repetition suppression  Tactile sensory processing  Tactile sensory seeking Index. décimale : PER Périodiques Résumé : BACKGROUNDS: Atypicalities in tactile processing are reported in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) but it remains unknown if they precede and associate with the traits of these disorders emerging in childhood. We investigated behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of ASD and/or ADHD compared to infants at typical likelihood of the disorders. Further, we assessed the specificity of associations between infant markers and later ASD or ADHD traits. METHODS: Ninety-one 10-month-old infants participated in the study (n = 44 infants at elevated likelihood of ASD; n = 20 infants at elevated likelihood of ADHD; n = 9 infants at elevated likelihood of ASD and ADHD; n = 18 infants at typical likelihood of the disorders). Behavioural and EEG responses to pairs of tactile stimuli were experimentally recorded and concurrent parental reports of tactile responsiveness were collected. ASD and ADHD traits were measured at 24 months through standardized assessment (ADOS-2) and parental report (ECBQ), respectively. RESULTS: There was no effect of infants' likelihood status on behavioural markers of tactile sensory processing. Conversely, increased ASD likelihood associated with reduced neural repetition suppression to tactile input. Reduced neural repetition suppression at 10 months significantly predicted ASD (but not ADHD) traits at 24 months across the entire sample. Elevated tactile sensory seeking at 10 months moderated the relationship between early reduced neural repetition suppression and later ASD traits. CONCLUSIONS: Reduced tactile neural repetition suppression is an early marker of later ASD traits in infants at elevated likelihood of ASD or ADHD, suggesting that a common pathway to later ASD traits exists despite different familial backgrounds. Elevated tactile sensory seeking may act as a protective factor, mitigating the relationship between early tactile neural repetition suppression and later ASD traits. En ligne : https://dx.doi.org/10.1186/s11689-020-09334-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis / Laurel A. FISH in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1308-1319 Titre : Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis Type de document : texte imprimé Auteurs : Laurel A. FISH, Auteur ; P. NYSTROM, Auteur ; Teodora GLIGA, Auteur ; Anna GUI, Auteur ; Jannath BEGUM-ALI, Auteur ; Luke MASON, Auteur ; Shruti GARG, Auteur ; Jonathan GREEN, Auteur ; Mark Henry JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Rebecca HARRISON, Auteur ; Emma MEABURN, Auteur ; Terje FALCK-YTTER, Auteur ; Emily Jane Harrison JONES, Auteur Article en page(s) : p.1308-1319 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Humans  Infant  Phenotype  Reflex  Autism spectrum disorder  infancy  neurodevelopment  pupillary light reflex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is heritable, the mechanisms through which genes contribute to symptom emergence remain unclear. Investigating candidate intermediate phenotypes such as the pupillary light reflex (PLR) prospectively from early in development could bridge genotype and behavioural phenotype. METHODS: Using eye tracking, we longitudinally measured the PLR at 9, 14 and 24 months in a sample of infants (N = 264) enriched for a family history of ASD; 27 infants received an ASD diagnosis at 3 years. We examined the 9- to 24-month developmental trajectories of PLR constriction latency (onset; ms) and amplitude (%) and explored their relation to categorical 3-year ASD outcome, polygenic liability for ASD and dimensional 3-year social affect (SA) and repetitive/restrictive behaviour (RRB) traits. Polygenic scores for ASD (PGS(ASD) ) were calculated for 190 infants. RESULTS: While infants showed a decrease in latency between 9 and 14 months, higher PGS(ASD) was associated with a smaller decrease in latency in the first year (β = -.16, 95% CI = -0.31, -0.002); infants with later ASD showed a significantly steeper decrease in latency (a putative 'catch-up') between 14 and 24 months relative to those with other outcomes (typical: β = .54, 95% CI = 0.08, 0.99; other: β = .53, 95% CI = 0.02, 1.04). Latency development did not associate with later dimensional variation in ASD-related traits. In contrast, change in amplitude was not related to categorical ASD or genetics, but decreasing 9- to 14-month amplitude was associated with higher SA (β = .08, 95% CI = 0.01, 0.14) and RRB (β = .05, 95% CI = 0.004, 0.11) traits. CONCLUSIONS: These findings corroborate PLR development as possible intermediate phenotypes being linked to both genetic liability and phenotypic outcomes. Future work should incorporate alternative measures (e.g. functionally informed structural and genetic measures) to test whether distinct neural mechanisms underpin PLR alterations. En ligne : http://dx.doi.org/10.1111/jcpp.13518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis [texte imprimé] / Laurel A. FISH, Auteur ; P. NYSTROM, Auteur ; Teodora GLIGA, Auteur ; Anna GUI, Auteur ; Jannath BEGUM-ALI, Auteur ; Luke MASON, Auteur ; Shruti GARG, Auteur ; Jonathan GREEN, Auteur ; Mark Henry JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Rebecca HARRISON, Auteur ; Emma MEABURN, Auteur ; Terje FALCK-YTTER, Auteur ; Emily Jane Harrison JONES, Auteur . - p.1308-1319. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1308-1319 Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Humans  Infant  Phenotype  Reflex  Autism spectrum disorder  infancy  neurodevelopment  pupillary light reflex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is heritable, the mechanisms through which genes contribute to symptom emergence remain unclear. Investigating candidate intermediate phenotypes such as the pupillary light reflex (PLR) prospectively from early in development could bridge genotype and behavioural phenotype. METHODS: Using eye tracking, we longitudinally measured the PLR at 9, 14 and 24 months in a sample of infants (N = 264) enriched for a family history of ASD; 27 infants received an ASD diagnosis at 3 years. We examined the 9- to 24-month developmental trajectories of PLR constriction latency (onset; ms) and amplitude (%) and explored their relation to categorical 3-year ASD outcome, polygenic liability for ASD and dimensional 3-year social affect (SA) and repetitive/restrictive behaviour (RRB) traits. Polygenic scores for ASD (PGS(ASD) ) were calculated for 190 infants. RESULTS: While infants showed a decrease in latency between 9 and 14 months, higher PGS(ASD) was associated with a smaller decrease in latency in the first year (β = -.16, 95% CI = -0.31, -0.002); infants with later ASD showed a significantly steeper decrease in latency (a putative 'catch-up') between 14 and 24 months relative to those with other outcomes (typical: β = .54, 95% CI = 0.08, 0.99; other: β = .53, 95% CI = 0.02, 1.04). Latency development did not associate with later dimensional variation in ASD-related traits. In contrast, change in amplitude was not related to categorical ASD or genetics, but decreasing 9- to 14-month amplitude was associated with higher SA (β = .08, 95% CI = 0.01, 0.14) and RRB (β = .05, 95% CI = 0.004, 0.11) traits. CONCLUSIONS: These findings corroborate PLR development as possible intermediate phenotypes being linked to both genetic liability and phenotypic outcomes. Future work should incorporate alternative measures (e.g. functionally informed structural and genetic measures) to test whether distinct neural mechanisms underpin PLR alterations. En ligne : http://dx.doi.org/10.1111/jcpp.13518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Disrupted visual attention relates to cognitive development in infants with Neurofibromatosis Type 1 / Jannath BEGUM-ALI in Journal of Neurodevelopmental Disorders, 17 (2025)  

Permalink

Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I / Jannath BEGUM-ALI in Journal of Neurodevelopmental Disorders, 13 (2021)  

Permalink

Facial expression recognition is linked to clinical and neurofunctional differences in autism / Hannah MEYER-LINDENBERG in Molecular Autism, 13 (2022)  

Permalink

Infant excitation/inhibition balance interacts with executive attention to predict autistic traits in childhood / Virginia CARTER LENO in Molecular Autism, 13 (2022)  

Permalink

Infant sleep predicts trajectories of social attention and later autism traits / Jannath BEGUM-ALI in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

Permalink

Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study / Nico BAST in Molecular Autism, 16 (2025)  

Permalink

Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD / Anna GUI in Development and Psychopathology, 32-4 (October 2020)  

Permalink

Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers / Luke MASON in Molecular Autism, 12 (2021)  

Permalink

Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)  

Permalink

Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder / Nico BAST in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

Permalink

---

1 2 (1 - 15 / 23) Par page : 25 50 100 200